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Strain |
Phenotype |
Conditions |
Study |
Experiment Name |
Sex |
Age |
# of Animals |
Value |
Units |
SEM |
SD |
Method |
Method Duration |
Post Insult Time Value |
Clinical Measurement Notes |
Record ID |
Study ID |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
microMolar |
107080 |
3073 |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
control condition |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
14 |
0.07 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
microMolar |
107077 |
3073 |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
8 |
0.07 |
umol/l |
0.01 |
0.03 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
microMolar |
107078 |
3073 |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
9 |
0.08 |
umol/l |
0.02 |
0.05 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
microMolar |
107082 |
3073 |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled BAY60-4552 content diet (0.3 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
4 |
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
|
107081 |
3073 |
SHRSP/A3NCrl |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium chloride content drinking water (1 %) (for 56 days) and controlled fat content diet (24.5 %) (for 56 days) then controlled GSK2181236A content diet (0.1 mg/kg/d) (for 49 days) |
Costell MH, etal., Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012. |
vasoconstriction trait |
male |
141 days-148 days |
6 |
0.05 |
umol/l |
0.01 |
0.02 |
tissue force analysis utilizing a force transducer |
0.0 |
0 |
microMolar |
107079 |
3073 |
|