Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 1c,Condition 2a,Condition 2b,Condition 2c,Condition 3a,Condition 3b,Condition 4,Condition 5 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,Kcl-induced blood vessel constriction expressed as percent of force at baseline,,312.35,%,20.21,53.4706,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) ,84680,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),potassium chloride solution (100 mmol/l) ,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,KCl-induced blood vessel constriction expressed as percent of force at baseline,,301.44,%,27.24,86.1404,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) ,84681,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),potassium chloride solution (100 mmol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,694.94,%,34.53,91.3578,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84672,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,607.58,%,51.55,163.0154,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84673,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,542.39,%,49.85,122.1071,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84674,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,641.52,%,62.37,152.7747,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84675,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,756.89,%,61.56,162.8725,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84676,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,626.89,%,61.39,184.17,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84677,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,phenylephrine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,564.27,%,57.82,141.6295,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84678,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,665.33,%,79.91,178.6842,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84679,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,phenylephrine (31.6 umol/l) , 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0001400,maximum body weight loss to initial body weight ratio,,,,3.6,%,0.8,2.2627,MMO:0000016,body weighing method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107182,arterial catheter implantation (for 1 days),,,,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.12,0.3175,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84648,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8,,0.09,0.2846,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84649,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.17,0.4164,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84650,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.4,,0.21,0.4696,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84651,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.08,,0.11,0.2694,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84668,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.93,,0.15,0.4743,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84669,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,,sodium nitroprusside (0-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.37,,0.13,0.3439,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84670,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.24,,0.13,0.3184,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84671,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,,sodium nitroprusside (0-9.5 umol/l) , 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-28,mmHg,4.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67262,controlled sodium content diet (0.15 %) (for 21 days),,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-23,mmHg,3.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67268,controlled sodium content diet (4 %) (for 21 days),,,ruthenium red (3 mg/kg) ,,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-27,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67264,controlled sodium content diet (4 %) (for 21 days),,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-22,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67267,controlled sodium content diet (0.15 %) (for 21 days),,,ruthenium red (3 mg/kg) ,,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,7,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) ,67271,controlled sodium content diet (0.15 %) ,,,ruthenium red (3 mg/kg) ,,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,4,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) ,67272,controlled sodium content diet (4 %) ,,,ruthenium red (3 mg/kg) ,,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-10,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67275,controlled sodium content diet (0.15 %) ,,,apamin (100 ug/kg) ,charybdotoxin (100 ug/kg) ,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-7,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67276,controlled sodium content diet (4 %) ,,,apamin (100 ug/kg) ,charybdotoxin (100 ug/kg) ,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-14,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67236,controlled sodium content diet (4 %) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-31,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67238,controlled sodium content diet (0.15 %) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-5,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67241,controlled sodium content diet (0.15 %) ,,,ruthenium red (3 mg/kg) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-4,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67242,controlled sodium content diet (4 %) ,,,ruthenium red (3 mg/kg) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,164,mmHg,5.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) ,67229,controlled sodium content diet (4 %) ,,,,,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0002215,SS/HsdMcwiCrl,male,56 days to 35 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,107,mmHg,4.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,control condition (0.15 %) ,67232,control condition (0.15 %) ,,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,109,mmHg,3.0,6.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),106756,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,149,mmHg,4.0,8.9443,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106776,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,153,mmHg,8.0,16.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106758,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,150,mmHg,8.0,16.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106762,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,110,mmHg,2.0,4.4721,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106764,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,111,mmHg,4.0,8.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106765,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,candesartan (0.5 ug/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,135,mmHg,4.0,8.9443,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106766,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,candesartan (0.5 ug/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,109,mmHg,2.0,4.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),106767,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,149,mmHg,3.0,6.7082,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106768,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",arterial blood pressure trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000009,mean arterial blood pressure,MAP=.33(SP-DP) + DP,,,128,mmHg,6.0,13.4164,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours),106769,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,kynurenate (0.14 ug/min) (for 0.2 hours),,,candesartan (0.5 ug/min) (for 0.2 hours),,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",arterial blood pressure trait,Initial MAP,RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0000009,mean arterial blood pressure,,,,123,mmHg,4.0,11.3137,MMO:0000013,vascular fluid filled catheter,,300.0,5-second intervals,,,,arterial catheter implantation (for 1 days),107336,arterial catheter implantation (for 1 days),,,,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",urine sodium amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000760,urine sodium excretion rate,,,,6,mEq/d,0.9,2.3812,MMO:0000177,automated urine analysis,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67667,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",urine sodium amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0000760,urine sodium excretion rate,,,,6.4,mEq/d,0.4,1.2,MMO:0000177,automated urine analysis,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67668,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",urine sodium amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000760,urine sodium excretion rate,,,,9,mEq/d,1.3,3.4395,MMO:0000177,automated urine analysis,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67669,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",urine sodium amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000760,urine sodium excretion rate,,,,5.9,mEq/d,0.4,0.8,MMO:0000177,automated urine analysis,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67670,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0000037,hematocrit,,,,39.3,%,0.6,1.6971,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days),107240,arterial catheter implantation (for 1 days),,,,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0000037,hematocrit,,,,28.2,%,1.3,3.677,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours),107256,arterial catheter implantation (for 1 days),,,controlled hemorrhage (between 1 and 6 hours),,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.24,%,0.82,2.1695,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67673,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.71,%,0.27,0.6614,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69616,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.53,%,0.41,1.2965,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69617,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.24,%,0.28,0.6859,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69618,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.14,%,0.37,0.9063,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69619,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,94.99,%,0.39,0.8721,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) ,69620,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,64.5,%,15.34,48.5093,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69621,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,91.96,%,2.76,6.7606,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69622,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,92.95,%,1.46,3.5763,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69623,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,70.84,%,4.18,8.36,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84652,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,73.42,%,5.62,14.8691,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84653,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,80.04,%,2.63,5.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84654,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,78.37,%,1.3,2.9069,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84655,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-19.03,%,4.01,9.8225,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) ,84656,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-29.33,%,4.38,13.8508,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84657,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-12.94,%,4.38,11.5884,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84658,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-16.62,%,7.27,17.8078,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84659,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,N/A,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,95.47,%,2.53,,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84662,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.4,,0.1,0.3162,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84641,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84642,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84643,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.2,,0.1,0.2236,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) ,84644,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.3,,0.2,0.5657,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84645,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.6,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84646,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.7,,0.2,0.4472,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84647,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-7.1,,0.1,0.2,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84640,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-6.31,,0.1,0.2,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84664,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.33,,0.25,0.6614,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84665,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,,acetylcholine (0-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.13,0.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84666,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.09,0.2012,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) ,84667,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,,acetylcholine (0.001-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",drinking behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000741,water drink intake rate,,,,30.1,ml/d,1.8,5.0912,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67663,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",drinking behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0000741,water drink intake rate,,,,21.8,ml/d,1.6,4.8,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67664,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",drinking behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000741,water drink intake rate,,,,18.4,ml/d,2.4,6.3498,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67665,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",drinking behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000741,water drink intake rate,,,,30.1,ml/d,0.8,1.7889,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67666,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,444,beats/min,7.0,14.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),106774,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000002,heart rate,,,,454,beats/min,7.0,15.6525,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106775,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000002,heart rate,,,,444,beats/min,16.0,35.7771,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106777,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,442,beats/min,5.0,10.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106778,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,425,beats/min,11.0,22.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106779,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,459,beats/min,9.0,18.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106782,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,candesartan (0.5 ug/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000002,heart rate,,,,466,beats/min,10.0,22.3607,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours),106783,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,candesartan (0.5 ug/min) (for 0.2 hours),,,kynurenate (0.14 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,5,,CMO:0000002,heart rate,,,,410,beats/min,15.0,33.541,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours),106784,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,kynurenate (0.14 ug/min) (for 0.2 hours),,,candesartan (0.5 ug/min) (for 0.2 hours),,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,442,beats/min,4.0,8.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),106770,controlled sodium chloride content diet (0.1 %) (between 28 and 42 days),,,,,,,,, 2685,"Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.",heart pumping trait,,RS:0002215,SS/HsdMcwiCrl,male,98 days to 77 days,4,,CMO:0000002,heart rate,,,,435,beats/min,12.0,24.0,MMO:0000013,vascular fluid filled catheter,femoral artery,600.0,,,,,controlled sodium chloride content diet (8 %) (between 28 and 42 days),106771,controlled sodium chloride content diet (8 %) (between 28 and 42 days),,,,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",total urine protein amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000756,urine total protein excretion rate,,,,0.6,mg/d,0.1,0.2449,MMO:0000424,bicinchoninic acid protein assay,,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),69612,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",total urine protein amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0000756,urine total protein excretion rate,,,,1,mg/d,0.2,0.6,MMO:0000424,bicinchoninic acid protein assay,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),69613,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",total urine protein amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000756,urine total protein excretion rate,,,,0.7,mg/d,0.07,0.1715,MMO:0000424,bicinchoninic acid protein assay,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),69614,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",total urine protein amount,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000756,urine total protein excretion rate,,,,0.8,mg/d,0.06,0.147,MMO:0000424,bicinchoninic acid protein assay,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),69615,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,97.36,%,0.65,1.7197,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67671,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.65,%,1.91,6.04,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67672,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.54,%,0.51,1.2492,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67674,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.76,%,0.68,1.6657,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84660,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.25,%,1.6,5.0596,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84661,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,,sodium nitroprusside (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,99.39,%,0.74,1.8126,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84663,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,,sodium nitroprusside (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",tibia length,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000450,tibia length,,,,4.24,cm,0.01,0.0265,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67610,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",tibia length,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0000450,tibia length,,,,4.26,cm,0.02,0.06,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67611,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",tibia length,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000450,tibia length,,,,4.3,cm,0.03,0.0735,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67612,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",tibia length,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000450,tibia length,,,,4.34,cm,0.03,0.0849,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67613,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",eating behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000427,food intake rate,,,,25.2,g/d,1.3,3.677,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67659,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",eating behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0000427,food intake rate,,,,21.4,g/d,1.1,3.3,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67660,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",eating behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000427,food intake rate,,,,20.9,g/d,1.4,3.7041,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67661,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",eating behavior trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000427,food intake rate,,,,25.4,g/d,1.2,2.6833,MMO:0000160,unspecified method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67662,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,94 days to 88 days,8,,CMO:0000012,body weight,,,,341,g,16.0,45.2548,MMO:0000016,body weighing method,,0.0,,,,,control condition,107348,control condition,,,,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0001197,body weight to tibia length ratio,,,,97.84,g/cm,0.03,0.0849,MMO:0000016,body weighing method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67617,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0001197,body weight to tibia length ratio,,,,98.04,g/cm,2.35,7.05,MMO:0000016,body weighing method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67615,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0001197,body weight to tibia length ratio,,,,96.12,g/cm,1.28,3.1353,MMO:0000016,body weighing method,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67616,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",body mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0001197,body weight to tibia length ratio,,,,100.21,g/cm,1.76,4.6565,MMO:0000016,body weighing method,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67614,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",heart mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0001198,heart weight to tibia length ratio,,,,0.37,g/cm,0.02,0.0529,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days),67618,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),,,,,controlled protein content diet (33 %) (for 91 days),,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",heart mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0001198,heart weight to tibia length ratio,,,,0.34,g/cm,0.01,0.03,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67619,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",heart mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0001198,heart weight to tibia length ratio,,,,0.31,g/cm,0.01,0.0245,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days),67620,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),,,,,controlled protein content diet (19 %) (for 91 days),,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",heart mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0001198,heart weight to tibia length ratio,,,,0.32,g/cm,0.01,0.0283,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67621,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",kidney mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0001199,both kidneys wet weight to tibia length ratio,,,,0.81,g/cm,0.03,0.0794,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days),67639,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),,,,,controlled protein content diet (33 %) (for 91 days),,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",kidney mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0001199,both kidneys wet weight to tibia length ratio,,,,0.73,g/cm,0.01,0.03,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67641,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",kidney mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0001199,both kidneys wet weight to tibia length ratio,,,,0.71,g/cm,0.03,0.0735,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days),67642,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),,,,,controlled protein content diet (19 %) (for 91 days),,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",kidney mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0001199,both kidneys wet weight to tibia length ratio,,,,0.75,g/cm,0.03,0.0849,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67643,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",epididymal fat pad mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0001201,epididymal fat pad weight to tibia length ratio,,,,1.17,g/cm,0.05,0.1323,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days),67652,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",epididymal fat pad mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0001201,epididymal fat pad weight to tibia length ratio,,,,1.33,g/cm,0.07,0.21,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days),67653,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",epididymal fat pad mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0001201,epididymal fat pad weight to tibia length ratio,,,,1.21,g/cm,0.09,0.2205,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days),67654,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),,,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",epididymal fat pad mass,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0001201,epididymal fat pad weight to tibia length ratio,,,,1.21,g/cm,0.12,0.3394,MMO:0000005,post excision weight measurement,,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days),67655,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",eating behavior trait,Food consumed (g) postsurgery per 100 g BW,RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0002214,food intake weight to body weight ratio,,,,5.2,g/d/100g,0.4,1.1314,MMO:0000620,food intake measuring method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107145,arterial catheter implantation (for 1 days),,,,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",drinking behavior trait,Water consumed (g) postsurgery per 100 g BW,RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0002859,water intake drink rate to body weight ratio,,,,0.33,ml/d/kg,0.07,0.198,MMO:0000619,drink intake measuring method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107161,arterial catheter implantation (for 1 days),,,,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",blood amount,,RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0003663,volume of blood removed to total prehemorrhagic blood volume ratio,5.83 mL/100 g of body weight,volume of blood removed to total prehemorrhagic blood volume ratio (CMO:0003663),,56.5,%,0.6,1.6971,MMO:0000016,body weighing method,,,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours),109130,arterial catheter implantation (for 1 days),,,controlled hemorrhage (between 1 and 6 hours),,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0002215,SS/HsdMcwiCrl,male,95 days to 89 days,8,,CMO:0002538,absolute change in hematocrit,,,,11,%,2.1,5.9397,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours),107272,arterial catheter implantation (for 1 days),,,controlled hemorrhage (between 1 and 6 hours),,,,,,