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Study IDStudyExperiment NameExperiment NotesStrain Ont IDStrainSexAge# of AnimalsSample NotesClinical Measurement Ont IDPhenotypeFormulaClinical Measurement NotesAverage TypeValueUnitsSEMSDMethod Ont IDMethodMethod SiteMethod DurationMethod NotesPost Insult TypePost Insult Time ValuePost Insult Time UnitConditionsRecord IDCondition 1aCondition 1bCondition 1cCondition 2aCondition 2bCondition 2cCondition 3aCondition 3bCondition 4Condition 5
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-28mmHg4.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67262controlled sodium content diet (0.15 %) (for 21 days)dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-23mmHg3.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67268controlled sodium content diet (4 %) (for 21 days)ruthenium red (3 mg/kg) dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-27mmHg1.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67264controlled sodium content diet (4 %) (for 21 days)dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-22mmHg1.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) 67267controlled sodium content diet (0.15 %) (for 21 days)ruthenium red (3 mg/kg) dihydrocapsaicin (30 ug/kg) pentobarbital (50 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure7mmHg1.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) 67271controlled sodium content diet (0.15 %) ruthenium red (3 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure4mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) 67272controlled sodium content diet (4 %) ruthenium red (3 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-10mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67275controlled sodium content diet (0.15 %) apamin (100 ug/kg) charybdotoxin (100 ug/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-7mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67276controlled sodium content diet (4 %) apamin (100 ug/kg) charybdotoxin (100 ug/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-14mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67236controlled sodium content diet (4 %) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-31mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67238controlled sodium content diet (0.15 %) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-5mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67241controlled sodium content diet (0.15 %) ruthenium red (3 mg/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000533absolute change in mean arterial blood pressure-4mmHg2.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) 67242controlled sodium content diet (4 %) ruthenium red (3 mg/kg) 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000009mean arterial blood pressure164mmHg5.0MMO:0000031tail cuff plethysmography0.0controlled sodium content diet (4 %) 67229controlled sodium content diet (4 %)
731Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.arterial blood pressure traitDR strain is from Charles River Laboratory, Wilmington, MARS:0002215SS/HsdMcwiCrlmale56 days to 35 daysN/ACMO:0000009mean arterial blood pressure107mmHg4.0MMO:0000031tail cuff plethysmography0.0control condition (0.15 %) 67232control condition (0.15 %)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0002460potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100Kcl-induced blood vessel constriction expressed as percent of force at baseline312.35%20.2153.4706MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) 84680controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)potassium chloride solution (100 mmol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0002460potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100KCl-induced blood vessel constriction expressed as percent of force at baseline301.44%27.2486.1404MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) 84681controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)potassium chloride solution (100 mmol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline694.94%34.5391.3578MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) 84672controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline607.58%51.55163.0154MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) 84673controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline542.39%49.85122.1071MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) 84674controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline641.52%62.37152.7747MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) 84675controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline756.89%61.56162.8725MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84676controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline626.89%61.39184.17MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84677controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline564.27%57.82141.6295MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84678controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasoconstriction traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0002459phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100phenylephrine-induced blood vessel constriction expressed as percent of force at baseline665.33%79.91178.6842MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) 84679controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)phenylephrine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.90.120.3175MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84648controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-80.090.2846MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84649controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.90.170.4164MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84650controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-8.40.210.4696MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 84651controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-8.080.110.2694MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84668controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.930.150.4743MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84669controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-8.370.130.3439MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84670controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000727logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-8.240.130.3184MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) 84671controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (0-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.urine sodium amountRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000760urine sodium excretion rate6mEq/d0.92.3812MMO:0000177automated urine analysis0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67667controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.urine sodium amountRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0000760urine sodium excretion rate6.4mEq/d0.41.2MMO:0000177automated urine analysis0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67668controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.urine sodium amountRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000760urine sodium excretion rate9mEq/d1.33.4395MMO:0000177automated urine analysis0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67669controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.urine sodium amountRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000760urine sodium excretion rate5.9mEq/d0.40.8MMO:0000177automated urine analysis0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67670controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10098.24%0.822.1695MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67673controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10099.71%0.270.6614MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69616controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10099.53%0.411.2965MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69617controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100100.24%0.280.6859MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69618controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100100.14%0.370.9063MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) 69619controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10094.99%0.390.8721MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) 69620controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10064.5%15.3448.5093MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69621controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10091.96%2.766.7606MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69622controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10092.95%1.463.5763MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) 69623controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10070.84%4.188.36MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84652controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10073.42%5.6214.8691MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84653controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10080.04%2.635.26MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84654controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 10078.37%1.32.9069MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) 84655controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100-19.03%4.019.8225MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) 84656controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100-29.33%4.3813.8508MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84657controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100-12.94%4.3811.5884MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84658controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] × 100-16.62%7.2717.8078MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) 84659controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (31.6 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 daysN/ACMO:0000731acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10095.47%2.53MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84662controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.40.10.3162MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84641controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.20.10.2449MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84642controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-7.20.10.2449MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84643controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.20.10.2236MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) 84644controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours)acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.30.20.5657MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84645controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.60.10.2449MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84646controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.70.20.4472MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) 84647controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) NG-nitroarginine methyl ester (100 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50logEC50-7.10.10.2MMO:0000342wire myographymesenteric artery0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) 84640controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)phenylephrine (2 umol/l) acetylcholine (0.001-9.5 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50logEC50-6.310.10.2MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84664controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.330.250.6614MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84665controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days4CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.490.130.26MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) 84666controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)phenylephrine (1 umol/l) acetylcholine (0-95 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000725logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)logEC50-6.490.090.2012MMO:0000342wire myographyaorta0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) 84667controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) acetylcholine (0.001-95 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.drinking behavior traitRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0000741water drink intake rate30.1ml/d1.85.0912MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67663controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.drinking behavior traitRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0000741water drink intake rate21.8ml/d1.64.8MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67664controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.drinking behavior traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000741water drink intake rate18.4ml/d2.46.3498MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67665controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.drinking behavior traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000741water drink intake rate30.1ml/d0.81.7889MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67666controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.total urine protein amountRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000756urine total protein excretion rate0.6mg/d0.10.2449MMO:0000424bicinchoninic acid protein assay0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)69612controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.total urine protein amountRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0000756urine total protein excretion rate1mg/d0.20.6MMO:0000424bicinchoninic acid protein assay0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)69613controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.total urine protein amountRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000756urine total protein excretion rate0.7mg/d0.070.1715MMO:0000424bicinchoninic acid protein assay0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)69614controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.total urine protein amountRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000756urine total protein excretion rate0.8mg/d0.060.147MMO:0000424bicinchoninic acid protein assay0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)69615controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10097.36%0.651.7197MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67671controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10096.65%1.916.04MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67672controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10098.54%0.511.2492MMO:0000342wire myographymesenteric artery0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) 67674controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (2 umol/l) sodium nitroprusside (0.316 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10098.76%0.681.6657MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84660controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days10CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10096.25%1.65.0596MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84661controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.vasodilation traitRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000732sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] × 10099.39%0.741.8126MMO:0000342wire myographyaorta0.0BCA assaycontrolled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) 84663controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)phenylephrine (1 umol/l) sodium nitroprusside (3.16 umol/l)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.tibia lengthRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000450tibia length4.24cm0.010.0265MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67610controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.tibia lengthRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0000450tibia length4.26cm0.020.06MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67611controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.tibia lengthRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0000450tibia length4.3cm0.030.0735MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67612controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.tibia lengthRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0000450tibia length4.34cm0.030.0849MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67613controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.eating behavior traitRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0000427food intake rate25.2g/d1.33.677MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67659controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.eating behavior traitRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0000427food intake rate21.4g/d1.13.3MMO:0000160unspecified method0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67660controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.eating behavior traitRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0000427food intake rate20.9g/d1.43.7041MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67661controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.eating behavior traitRS:0002215SS/HsdMcwiCrlmale112 days5CMO:0000427food intake rate25.4g/d1.22.6833MMO:0000160unspecified method0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67662controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.body massRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0001197body weight to tibia length ratio97.84g/cm0.030.0849MMO:0000016body weighing method0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67617controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.body massRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0001197body weight to tibia length ratio98.04g/cm2.357.05MMO:0000016body weighing method0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67615controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.body massRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0001197body weight to tibia length ratio96.12g/cm1.283.1353MMO:0000016body weighing method0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67616controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.body massRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0001197body weight to tibia length ratio100.21g/cm1.764.6565MMO:0000016body weighing method0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67614controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.heart massRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0001198heart weight to tibia length ratio0.37g/cm0.020.0529MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days)67618controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.heart massRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0001198heart weight to tibia length ratio0.34g/cm0.010.03MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67619controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.heart massRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0001198heart weight to tibia length ratio0.31g/cm0.010.0245MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days)67620controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.heart massRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0001198heart weight to tibia length ratio0.32g/cm0.010.0283MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67621controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.kidney massRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0001199both kidneys wet weight to tibia length ratio0.81g/cm0.030.0794MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) then controlled protein content diet (33 %) (for 91 days)67639controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.kidney massRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0001199both kidneys wet weight to tibia length ratio0.73g/cm0.010.03MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67641controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.kidney massRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0001199both kidneys wet weight to tibia length ratio0.71g/cm0.030.0735MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) then controlled protein content diet (19 %) (for 91 days)67642controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.kidney massRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0001199both kidneys wet weight to tibia length ratio0.75g/cm0.030.0849MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67643controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.epididymal fat pad massRS:0002215SS/HsdMcwiCrlmale112 days7CMO:0001201epididymal fat pad weight to tibia length ratio1.17g/cm0.050.1323MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days)67652controlled carbohydrate content diet (53 %) (for 91 days)controlled fat content diet (14 %) (for 91 days)controlled protein content diet (33 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.epididymal fat pad massRS:0002215SS/HsdMcwiCrlmale112 days9CMO:0001201epididymal fat pad weight to tibia length ratio1.33g/cm0.070.21MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days)67653controlled carbohydrate content diet (53 %) (for 63 days)controlled fat content diet (14 %) (for 63 days)controlled protein content diet (33 %) (for 63 days)controlled carbohydrate content diet (69 %) (for 28 days)controlled fat content diet (12 %) (for 28 days)controlled protein content diet (19 %) (for 28 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.epididymal fat pad massRS:0002215SS/HsdMcwiCrlmale112 days6CMO:0001201epididymal fat pad weight to tibia length ratio1.21g/cm0.090.2205MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days)67654controlled carbohydrate content diet (69 %) (for 91 days)controlled fat content diet (12 %) (for 91 days)controlled protein content diet (19 %) (for 91 days)
735Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.epididymal fat pad massRS:0002215SS/HsdMcwiCrlmale112 days8CMO:0001201epididymal fat pad weight to tibia length ratio1.21g/cm0.120.3394MMO:0000005post excision weight measurement0.0controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days)67655controlled carbohydrate content diet (69 %) (for 63 days)controlled fat content diet (12 %) (for 63 days)controlled protein content diet (19 %) (for 63 days)controlled carbohydrate content diet (53 %) (for 28 days)controlled fat content diet (14 %) (for 28 days)controlled protein content diet (33 %) (for 28 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP109mmHg3.06.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)106756controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP149mmHg4.08.9443MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106776controlled sodium chloride content diet (8 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP153mmHg8.016.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106758controlled sodium chloride content diet (8 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP150mmHg8.016.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106762controlled sodium chloride content diet (8 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP110mmHg2.04.4721MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106764controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP111mmHg4.08.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106765controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP135mmHg4.08.9443MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106766controlled sodium chloride content diet (8 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP109mmHg2.04.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)106767controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP149mmHg3.06.7082MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106768controlled sodium chloride content diet (8 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.arterial blood pressure traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000009mean arterial blood pressureMAP=.33(SP-DP) + DP128mmHg6.013.4164MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours)106769controlled sodium chloride content diet (8 %) (between 28 and 42 days)kynurenate (0.14 ug/min) (for 0.2 hours)candesartan (0.5 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate444beats/min7.014.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)106774controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000002heart rate454beats/min7.015.6525MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106775controlled sodium chloride content diet (8 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000002heart rate444beats/min16.035.7771MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106777controlled sodium chloride content diet (8 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate442beats/min5.010.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106778controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate425beats/min11.022.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then 2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106779controlled sodium chloride content diet (8 %) (between 28 and 42 days)2% dimethyl sulfoxide in artificial cerebrospinal fluid (300 nl/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate459beats/min9.018.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106782controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000002heart rate466beats/min10.022.3607MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then candesartan (0.5 ug/min) (for 0.2 hours) then kynurenate (0.14 ug/min) (for 0.2 hours)106783controlled sodium chloride content diet (8 %) (between 28 and 42 days)candesartan (0.5 ug/min) (for 0.2 hours)kynurenate (0.14 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days5CMO:0000002heart rate410beats/min15.033.541MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days) then kynurenate (0.14 ug/min) (for 0.2 hours) then candesartan (0.5 ug/min) (for 0.2 hours)106784controlled sodium chloride content diet (8 %) (between 28 and 42 days)kynurenate (0.14 ug/min) (for 0.2 hours)candesartan (0.5 ug/min) (for 0.2 hours)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate442beats/min4.08.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)106770controlled sodium chloride content diet (0.1 %) (between 28 and 42 days)
2685Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1.heart pumping traitRS:0002215SS/HsdMcwiCrlmale98 days to 77 days4CMO:0000002heart rate435beats/min12.024.0MMO:0000013vascular fluid filled catheterfemoral artery600.0controlled sodium chloride content diet (8 %) (between 28 and 42 days)106771controlled sodium chloride content diet (8 %) (between 28 and 42 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.body massRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0001400maximum body weight loss to initial body weight ratio3.6%0.82.2627MMO:0000016body weighing method0.0arterial catheter implantation1daysarterial catheter implantation (for 1 days)107182arterial catheter implantation (for 1 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.arterial blood pressure traitInitial MAPRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0000009mean arterial blood pressure123mmHg4.011.3137MMO:0000013vascular fluid filled catheter300.05-second intervalsarterial catheter implantation (for 1 days)107336arterial catheter implantation (for 1 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.erythrocyte quantityinitial hematocrit, final hematocrit, change in hematocritRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0000037hematocrit39.3%0.61.6971MMO:0000215microhematocrit tube assay with visual assessment0.0arterial catheter implantation (for 1 days)107240arterial catheter implantation (for 1 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.erythrocyte quantityinitial hematocrit, final hematocrit, change in hematocritRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0000037hematocrit28.2%1.33.677MMO:0000215microhematocrit tube assay with visual assessment0.0arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)107256arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.body massRS:0002215SS/HsdMcwiCrlmale94 days to 88 days8CMO:0000012body weight341g16.045.2548MMO:0000016body weighing method0.0control condition107348control condition
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.eating behavior traitFood consumed (g) postsurgery per 100 g BWRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0002214food intake weight to body weight ratio5.2g/d/100g0.41.1314MMO:0000620food intake measuring method0.0arterial catheter implantation1daysarterial catheter implantation (for 1 days)107145arterial catheter implantation (for 1 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.drinking behavior traitWater consumed (g) postsurgery per 100 g BWRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0002859water intake drink rate to body weight ratio0.33ml/d/kg0.070.198MMO:0000619drink intake measuring method0.0arterial catheter implantation1daysarterial catheter implantation (for 1 days)107161arterial catheter implantation (for 1 days)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.blood amountRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0003663volume of blood removed to total prehemorrhagic blood volume ratio5.83 mL/100 g of body weightvolume of blood removed to total prehemorrhagic blood volume ratio (CMO:0003663)56.5%0.61.6971MMO:0000016body weighing methodarterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)109130arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)
3077Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.erythrocyte quantityinitial hematocrit, final hematocrit, change in hematocritRS:0002215SS/HsdMcwiCrlmale95 days to 89 days8CMO:0002538absolute change in hematocrit11%2.15.9397MMO:0000215microhematocrit tube assay with visual assessment0.0arterial catheter implantation (for 1 days) then controlled hemorrhage (between 1 and 6 hours)107272arterial catheter implantation (for 1 days)controlled hemorrhage (between 1 and 6 hours)

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