Phenominer Database Results (452 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 7BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 181.19 % 10.05 30.16 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54264 381
SS-Chr 7BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 163.55 breaths/min 10.63 31.9 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17157 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 121.46 % 3.4 10.74 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53934 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 136.2 % 10.9 32.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53798 381
SS-Chr 7BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 449.19 beats/min 18.96 56.87 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20917 381
SS-Chr 7BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 8.18 x 1000 cells/ul 0.51 1.69 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36876 401
SS-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 6.02 g/dl 0.1 0.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37007 401
SS-Chr 7BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.44 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14603 381
SS-Chr 7BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 10 392.42 beats/min 6.65 21.03 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52642 482
SS-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 9 0.51 ng/ml/h 0.12 0.37 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52446 482
SS-Chr 7BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 11 1.31 ng/ml/h 0.26 0.87 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52449 482
SS-Chr 7BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 11 114.93 mg/d 12.15 40.3 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52694 482
SS-Chr 7BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 383.32 beats/min 6.77 17.91 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17745 381
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 11 132.27 U/l 6.32 20.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37464 401
SS-Chr 7BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 11 144.36 mmol/l 0.34 1.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36504 401
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 45.09 ml/min 5.7 17.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18708 381
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 9 438.83 beats/min 28.19 84.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17499 381
SS-Chr 7BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 145.64 mmol/l 0.41 1.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36497 401
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 %change=VE during 2-3 min hypercapnia/control during standard conditions 299.37 % 14.7 53.0 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19262 381
SS-Chr 7BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 25 0.86 g 0.01 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49110 461
SS-Chr 7BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.82 mg/dl 0.14 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36766 401
SS-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.64 g/dl 0.11 0.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42278 401
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 58.92 % 1.0 3.31 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39036 401
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 53.23 % 0.59 2.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39041 401
SS-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 62.35 fl 0.34 1.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38795 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 20.53 pg 0.16 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42595 401
SS-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.93 x 1000 cells/ul 0.08 0.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43269 401
SS-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.51 x 1000 cells/ul 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39719 401
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 160.1 g 3.5 12.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59112 526
SS-Chr 7BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 11 0.45 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40301 401
SS-Chr 7BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 11 4.03 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40421 401
SS-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 8.12 x 1000 cells/ul 0.51 1.68 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40971 401
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.06 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59372 526
SS-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 20.33 mg/dl 0.84 2.9 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40878 401
SS-Chr 7BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 105.82 mmol/l 0.54 1.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40013 401
SS-Chr 7BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 11 105.64 mmol/l 0.61 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40020 401
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 53.23 % 0.59 2.04 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59307 526
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 1.34 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59702 526
SS-Chr 7BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 153.64 mg/dl 3.34 11.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41201 401
SS-Chr 7BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 99.45 mg/dl 3.18 10.54 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38440 401
SS-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41697 401
SS-Chr 7BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 1178.36 s 30.92 154.59 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46593 461
SS-Chr 7BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 7.75 x 10E6 cells/ul 0.13 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41976 401
SS-Chr 7BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 12 -8.25 null 0.06 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55273 522
SS-Chr 7BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 1.53 g/mg 0.15 0.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57339 522
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 25.05 ml/min/kg 2.01 6.96 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57845 526
SS-Chr 7BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 0.04 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55754 522
SS-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 12 0.24 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57908 526
SS-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.67 degrees C 0.15 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16618 381
SS-Chr 7BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 27.97 ml/min 2.16 6.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16736 381
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 49.07 ml/min/kg 2.97 10.28 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58234 526
SS-Chr 7BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 -8.12 null 0.07 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56103 522
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 12 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54672 522
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 27.75 % 3.91 13.56 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55151 522
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.12 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59895 526
SS-Chr 7BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.41 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17416 381
SS-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 5.48 g/kg 0.13 0.44 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45614 461
SS-Chr 7BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 26 222.0 g 5.0 25.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47811 461
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 86.31 % 5.58 20.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44963 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 94.89 mmHg 4.98 24.41 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44860 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 312.71 beats/min 57.23 180.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45197 461
SS-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 137.67 % 29.79 98.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48340 461
SS-Chr 7BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 11 14.58 mEq/d 1.41 4.68 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52745 482
SS-Chr 7BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 28.41 mmHg 3.51 9.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20731 381
SS-Chr 7BN/Mcwi absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 18.31 mmHg 3.53 11.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20738 381
SS-Chr 7BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 118.88 mmHg 4.95 13.09 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20053 381
SS-Chr 7BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 383.49 beats/min 14.07 37.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14686 381
SS-Chr 7BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 421.79 beats/min 8.13 22.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14694 381
SS-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 11 96.82 mg/dl 4.65 15.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37142 401
SS-Chr 7BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.52 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17036 381
SS-Chr 7BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 88.24 breaths/min 3.71 11.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18461 381
SS-Chr 7BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 heart rate during walking-heart rate during rest 88.74 beats/min 9.36 31.05 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13406 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 29.67 mmHg 0.52 1.37 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13433 381
SS-Chr 7BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 11 0.9 mEq/d 0.05 0.17 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52941 482
SS-Chr 7BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 0.05 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19772 381
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.93 mmHg 0.24 0.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47242 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 5.33 mmHg 0.24 0.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47246 461
SS-Chr 7BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 5.97 g/kg 0.23 0.71 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45620 461
SS-Chr 7BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 26 4.47 g/kg 0.09 0.45 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46989 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 63.29 % 4.57 22.4 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46116 461
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 47.42 % 2.36 8.17 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57186 522
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 17 131.94 mmHg 5.63 23.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45554 461
SS-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.4 null 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58783 526
SS-Chr 7BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 58.92 % 1.0 3.31 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59302 526
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 12 0.96 g/kg 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59461 526
SS-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 113.58 mmol/l 0.45 1.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39167 401
SS-Chr 7BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 1.49 E-7mole 0.22 0.77 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56525 522
SS-Chr 7BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.24 ml 0.01 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15448 381
SS-Chr 7BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 90.46 breaths/min 4.32 12.95 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14981 381
SS-Chr 7BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 112.52 mmHg 3.33 9.99 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15080 381
SS-Chr 7BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 8 453.22 beats/min 9.74 27.56 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15924 381
SS-Chr 7BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 188.93 % 12.86 46.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54268 381
SS-Chr 7BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 0.01 null 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14771 381
SS-Chr 7BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 118.5 mmHg 4.3 11.37 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13473 381
SS-Chr 7BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 113.21 mmHg 4.96 14.02 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13481 381
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.18 % 3.48 10.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53930 381
SS-Chr 7BN/Mcwi heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 415.41 beats/min 12.98 43.05 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17752 381
SS-Chr 7BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.3 ml 0.03 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18028 381
SS-Chr 7BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 37.81 degrees C 0.17 0.44 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18131 381
SS-Chr 7BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 11 6.26 g/dl 0.07 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37212 401
SS-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.53 mg/dl 0.09 0.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36674 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.41 g/dl 0.12 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37335 401
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 37.12 ml/min 2.76 8.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18713 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 -45.89 mmHg 3.9 10.32 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19451 381
SS-Chr 7BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.42 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20166 381
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 39.48 ml/min 3.93 11.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20254 381
SS-Chr 7BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 26 0.99 g 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49105 461
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 958.82 s 40.18 133.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49344 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 25 15.34 % 3.14 15.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49441 461
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 80.18 U/l 4.95 16.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42424 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 32.96 g/dl 0.11 0.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39822 401
SS-Chr 7BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.51 x 1000 cells/ul 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43274 401
SS-Chr 7BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42890 401
SS-Chr 7BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 189.02 % 10.78 38.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53683 381
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.26 mg/kg 0.24 0.77 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59172 526
SS-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.38 g/dl 0.07 0.23 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40595 401
SS-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.85 mg/dl 0.21 0.68 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37639 401
SS-Chr 7BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 14.15 g/dl 0.12 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40116 401
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.64 g/kg 0.03 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59707 526
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 57.55 U/l 2.56 8.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37714 401
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.37 null 0.02 0.06 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59780 526
SS-Chr 7BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 11 19.18 mg/dl 0.74 2.44 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41766 401
SS-Chr 7BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 7.33 x 10E6 cells/ul 0.06 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41983 401
SS-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 11 165.64 mg/dl 6.62 21.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38575 401
SS-Chr 7BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 164.33 mg/dl 4.74 16.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38580 401
SS-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41913 401
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 9 39.31 IU/g 3.65 10.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48857 461
SS-Chr 7BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 22.64 ml/min 1.17 3.52 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16193 381
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 14.5 ml/min/kg 1.0 3.46 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57643 526
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 18.8 ml/min/kg 1.06 3.67 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57648 526
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 9.2 mmHg 2.41 8.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16297 381
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 59.53 ml/min/kg 4.24 14.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58044 526
SS-Chr 7BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 0.91 E-7mole 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55892 522
SS-Chr 7BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 12 1.18 g/mg 0.09 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55786 522
SS-Chr 7BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.77 degrees C 0.27 0.87 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16863 381
SS-Chr 7BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 -8.42 null 0.08 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54625 522
SS-Chr 7BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 59.88 % 8.67 24.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54778 522
SS-Chr 7BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 57.45 % 4.68 15.52 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54785 522
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 12 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58539 526
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 14.77 ml/min/kg 1.08 3.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60008 526
SS-Chr 7BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 53.64 % 3.49 11.59 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57229 522
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 140.66 mmHg 8.75 23.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45774 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 124.61 mmHg 8.16 25.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46795 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 12 125.03 mmHg 6.21 21.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46800 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 6.73 ml/min/g 0.32 1.02 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44767 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 62.43 % 4.99 15.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47126 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 24 104.11 mmHg 3.72 18.22 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44865 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.3 IU/g 0.07 0.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47451 461
SS-Chr 7BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 161.37 % 7.08 25.53 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54134 381
SS-Chr 7BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 61.81 ml/min 3.19 11.51 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20812 381
SS-Chr 7BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 9 7.46 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20611 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 32.76 mmHg 1.03 2.71 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14470 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 9 100.52 mmHg 3.26 9.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18855 381
SS-Chr 7BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 131.94 mmHg 5.2 17.25 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18953 381
SS-Chr 7BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 0.07 null 0.01 0.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19780 381
SS-Chr 7BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 46.5 % 6.52 18.43 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57222 522
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 35.99 % 6.81 22.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46364 461
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 24 38.34 mmHg 3.76 18.43 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47751 461
SS-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 11 6.67 x 1000 cells/ul 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41548 401
SS-Chr 7BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 181.48 % 7.77 23.32 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53679 381
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 38.44 mmHg 4.86 15.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46466 461
SS-Chr 7BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 25 1268.36 s 34.4 172.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46598 461
SS-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.98 g 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45454 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 255.1 beats/min 12.21 40.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47627 461
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 30.58 % 3.67 12.71 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55063 522
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 53.81 % 8.05 24.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48576 461
SS-Chr 7BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 19.87 ml/min 1.46 5.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16198 381
SS-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 17.51 g/dl 0.18 0.63 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38018 401
SS-Chr 7BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 69.97 ml/min 4.19 12.57 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14546 381
SS-Chr 7BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 58.02 ml/min 3.2 11.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14551 381
SS-Chr 7BN/Mcwi blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 11 7.43 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14610 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 35.31 mmHg 0.88 2.91 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 14477 381
SS-Chr 7BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 8 421.78 beats/min 10.42 29.48 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15916 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.3 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15284 381
SS-Chr 7BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 0.07 degrees C 0.13 0.34 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16008 381
SS-Chr 7BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 0.13 degrees C 0.26 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15715 381
SS-Chr 7BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 152.18 breaths/min 5.83 21.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17162 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 7 28.01 mmHg 0.93 2.46 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17236 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -3.09 mmHg 1.11 2.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20087 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 -4.72 mmHg 0.63 2.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20094 381
SS-Chr 7BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 8 110.34 mmHg 2.82 7.97 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19854 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 117.47 breaths/min 7.76 24.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18316 381
SS-Chr 7BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 11 6.0 g/dl 0.08 0.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37205 401
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 127.82 breaths/min 9.4 28.2 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14840 381
SS-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 9 0.32 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52201 482
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 10 146.46 mmHg 2.72 8.6 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52840 482
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 10 143.49 mmHg 2.4 7.59 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52843 482
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 11 30.59 mmHg 0.51 1.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 13440 381
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 298.31 % 18.26 54.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14244 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 7 -5.06 mmHg 0.33 0.88 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19622 381
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 7 -6.71 mmHg 1.27 3.35 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19628 381
SS-Chr 7BN/Mcwi body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 38.3 degrees C 0.16 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 18138 381
SS-Chr 7BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 7 37.89 degrees C 0.14 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17647 381
SS-Chr 7BN/Mcwi blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 7.47 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Dyets 20159 381
SS-Chr 7BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.73 degrees C 0.25 0.75 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19115 381
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 141.27 % 8.67 26.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18589 381
SS-Chr 7BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 11 9.79 mg/dl 0.12 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36773 401
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 311.36 % 15.57 46.72 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19257 381
SS-Chr 7BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 34.07 ml/min 2.16 6.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20259 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 60.39 mmHg 2.66 7.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20471 381
SS-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.46 degrees C 0.22 0.71 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20360 381
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 164.6 g 2.0 6.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49522 461
SS-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 1134.7 s 93.78 311.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50272 461
SS-Chr 7BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 4.02 g/dl 0.07 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42283 401
SS-Chr 7BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 63.75 fl 0.44 1.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38790 401
SS-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 11 142.45 mmol/l 0.61 2.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39433 401
SS-Chr 7BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 142.42 mmol/l 0.31 1.08 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39438 401
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 141.87 % 8.28 24.83 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54371 381
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.91 g/dl 0.12 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39827 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 18.92 pg 0.17 0.57 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40205 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 19.28 pg 0.06 0.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40212 401
SS-Chr 7BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 14.65 g/dl 0.16 0.54 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40109 401
SS-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.3 mg/dl 0.02 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39626 401
SS-Chr 7BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.09 mg/dl 0.23 0.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37644 401
SS-Chr 7BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 6.27 x 1000 cells/ul 0.36 1.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40976 401
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.14 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59592 526
SS-Chr 7BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 11 2.33 g/dl 0.04 0.13 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41034 401
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.34 null 0.02 0.05 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59786 526
SS-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 18.36 mmol/l 1.39 4.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38306 401
SS-Chr 7BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 17.0 mmol/l 1.24 4.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38311 401
SS-Chr 7BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 11 58.37 fl 0.36 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38654 401
SS-Chr 7BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 11 59.81 fl 0.28 0.93 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38661 401
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 135.65 mmHg 9.45 21.12 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48669 461
SS-Chr 7BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 -8.11 null 0.09 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55280 522
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 79.88 % 4.94 14.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48805 461
SS-Chr 7BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 11 45.18 % 0.6 1.98 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57494 526
SS-Chr 7BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 11 43.84 % 0.4 1.33 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57501 526
SS-Chr 7BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 12 264.1 g 5.9 20.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55415 522
SS-Chr 7BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 102.23 mmHg 4.16 11.01 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16404 381
SS-Chr 7BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 246.2 g 7.8 27.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58345 526
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 0.43 null 0.02 0.08 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58158 526
SS-Chr 7BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.51 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58163 526
SS-Chr 7BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 0.84 E-7mole 0.07 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55899 522
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 0.01 umol/l 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54911 522
SS-Chr 7BN/Mcwi logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 -8.47 null 0.09 0.29 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54628 522
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 22.49 ml/min/kg 1.32 4.18 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58637 526
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.55 mg/kg 0.26 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58956 526
SS-Chr 7BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 12 187.6 g 2.3 7.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55186 522
SS-Chr 7BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -7.04 null 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56913 522
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 50.17 % 2.43 8.41 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57183 522
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 49.83 mmHg 3.92 19.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47746 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 25 44.32 mmHg 2.03 10.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48083 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 24 7.32 ml/min/g 0.67 3.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46246 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 24 7.5 ml/min/g 0.95 4.67 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46251 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 26 0.52 IU/g 0.07 0.37 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47304 461
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 25 0.39 IU/g 0.03 0.17 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47312 461
SS-Chr 7BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 112.21 mmHg 2.23 7.39 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15056 381
SS-Chr 7BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 13 0.12 degrees C 0.13 0.46 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15720 381
SS-Chr 7BN/Mcwi absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 heart rate during walking-heart rate during rest 87.77 beats/min 15.1 39.96 vascular fluid filled catheter 0 0 Moms and pups used in studies were fed Teklad 13401 381
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 %change=VE during7-9 min hypercapnia/control during standard conditions 319.19 % 15.89 57.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14249 381
SS-Chr 7BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 151.11 % 12.37 39.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18594 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.66 breaths/min 7.76 24.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14845 381
SS-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 11 15.16 mg/d 2.95 9.78 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52594 482
SS-Chr 7BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 25 249.32 beats/min 5.83 29.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48247 461
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 post-ischemic value/pre-ischemic value x 100% 51.67 % 4.84 18.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46369 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 11.14 ml/min/g 0.67 2.13 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46702 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 9.4 ml/min/g 0.34 1.71 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46915 461
SS-Chr 7BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 11 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42897 401
SS-Chr 7BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 2.36 g/mg 0.21 0.73 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55793 522
SS-Chr 7BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 11 21.36 mmol/l 0.7 2.34 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43004 401
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54904 522
SS-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 12 0.45 null 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58778 526
SS-Chr 7BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 11 2.24 g/dl 0.02 0.08 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41041 401
SS-Chr 7BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 100.0 % 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56481 522
SS-Chr 7BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 11 151.91 mg/dl 4.5 14.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41208 401
SS-Chr 7BN/Mcwi partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 11 103.01 mmHg 2.26 7.5 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16411 381
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 60.35 ml/min/kg 3.54 12.25 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58049 526
SS-Chr 7BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 11 0.25 mg/dl 0.02 0.05 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42660 401
SS-Chr 7BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.25 ml 0.01 0.02 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15443 381
SS-Chr 7BN/Mcwi absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 -0.22 degrees C 0.18 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16015 381
SS-Chr 7BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 171.86 % 5.67 17.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54130 381
SS-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 160.0 % 12.48 37.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13726 381
SS-Chr 7BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 7 471.1 beats/min 13.26 35.07 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13804 381
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.22 % 10.56 33.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53802 381
SS-Chr 7BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 409.94 beats/min 10.52 31.57 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20909 381
SS-Chr 7BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 95.06 breaths/min 4.0 11.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18456 381
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 279.0 U/l 15.14 50.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36424 401
SS-Chr 7BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 8 109.43 mmHg 4.22 11.93 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18863 381
SS-Chr 7BN/Mcwi mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 7 147.29 mmHg 4.51 11.93 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 18946 381
SS-Chr 7BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 84.23 breaths/min 5.68 20.49 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14986 381
SS-Chr 7BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 10 413.46 beats/min 4.88 15.44 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52645 482
SS-Chr 7BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 11 72.57 mg/d 8.11 26.89 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52691 482
SS-Chr 7BN/Mcwi absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 7 -0.03 null 0.01 0.03 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14764 381
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 11 221.09 U/l 8.19 27.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37457 401
SS-Chr 7BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 11 9.65 mg/dl 0.14 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36669 401
SS-Chr 7BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 24 220.58 beats/min 7.07 34.61 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48995 461
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 7 -49.09 mmHg 5.14 13.61 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19459 381
SS-Chr 7BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.03 degrees C 0.14 0.42 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20355 381
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 17 5.7 mmHg 0.14 0.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49222 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 9 399.96 beats/min 16.39 49.18 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17491 381
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 840.4 s 50.31 159.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49348 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 105.38 mmHg 5.66 17.89 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49937 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 11 42.36 mmHg 3.47 11.52 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50042 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 24 13.14 % 3.42 16.73 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49446 461
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 25 1047.72 s 30.21 151.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50169 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 10 5.58 % 3.58 11.34 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49747 461
SS-Chr 7BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 11 6.32 % 2.06 6.83 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49743 461
SS-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 16.5 mmol/l 0.96 3.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42112 401
SS-Chr 7BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 11 0.39 x 1000 cells/ul 0.08 0.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38910 401
SS-Chr 7BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.19 mg/dl 0.01 0.03 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42653 401
SS-Chr 7BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 11 9.52 x 1000 cells/ul 0.53 1.74 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39892 401
SS-Chr 7BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 11 22.91 mmol/l 0.44 1.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43138 401
SS-Chr 7BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 11 21.45 mmol/l 0.51 1.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43145 401
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 11 1.21 mg/kg 0.17 0.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59178 526
SS-Chr 7BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 11 3.67 g/dl 0.04 0.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40414 401
SS-Chr 7BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 11 3.96 mmol/l 0.11 0.37 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43341 401
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 12 205.5 g 5.6 19.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59107 526
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 41.25 U/l 1.9 6.57 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40764 401
SS-Chr 7BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 45.18 % 0.6 1.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41309 401
SS-Chr 7BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 11 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41418 401
SS-Chr 7BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 11 8.35 mg/dl 0.26 0.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37841 401
SS-Chr 7BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 11 1.19 g/kg 0.02 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59468 526
SS-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 9 5.28 mmol/l 0.11 0.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38111 401
SS-Chr 7BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 5.49 x 1000 cells/ul 0.34 1.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41553 401
SS-Chr 7BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41692 401
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 12 128.49 mmHg 6.68 23.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45549 461
SS-Chr 7BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.11 mg/dl 0.01 0.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41918 401
SS-Chr 7BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 12 180.2 g 2.8 9.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55420 522
SS-Chr 7BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.43 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16519 381
SS-Chr 7BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.38 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16524 381
SS-Chr 7BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.31 degrees C 0.13 0.41 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16623 381
SS-Chr 7BN/Mcwi concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 0.05 10E-7mol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55751 522
SS-Chr 7BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 66.94 ml/min/kg 2.42 7.66 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58240 526
SS-Chr 7BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 23.38 ml/min 1.82 5.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16741 381
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58534 526
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 19.75 % 2.66 9.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55148 522
SS-Chr 7BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 8 277.8 g 3.5 9.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55181 522
SS-Chr 7BN/Mcwi sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 99.8 % 0.2 0.63 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56484 522
SS-Chr 7BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 0.98 E-7mole 0.12 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56518 522
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 12.6 ml/min/kg 0.76 2.65 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60001 526
SS-Chr 7BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 12 -6.89 null 0.08 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56920 522
SS-Chr 7BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 9.74 ml/min/g 0.39 1.85 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46920 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 5.59 ml/min/g 0.25 0.84 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44763 461
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 135.21 mmHg 4.98 14.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45778 461
SS-Chr 7BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 240.06 beats/min 7.01 35.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48242 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 70.73 % 5.4 26.46 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46111 461
SS-Chr 7BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 121.62 % 23.04 72.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48344 461
SS-Chr 7BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 post-ischemic value/pre-ischemic value x 100% 95.92 % 13.53 66.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48451 461
SS-Chr 7BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 235.81 beats/min 28.81 138.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48990 461
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 105.42 % 3.66 10.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54031 381
SS-Chr 7BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 273.5 g 9.0 28.4 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17863 381
SS-Chr 7BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 17 191.0 g 2.6 10.9 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17868 381
SS-Chr 7BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 13 153.02 breaths/min 5.29 19.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16962 381
SS-Chr 7BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 133.22 breaths/min 6.39 19.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18311 381
SS-Chr 7BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 163.58 % 12.69 40.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13731 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13974 381
SS-Chr 7BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 9 2.08 ml/min 0.16 0.48 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52152 482
SS-Chr 7BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 11 1.76 ml/min 0.1 0.34 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52155 482
SS-Chr 7BN/Mcwi heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 11 504.15 beats/min 13.27 44.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13809 381
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 11 32.25 g/dl 0.13 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37342 401
SS-Chr 7BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 13 37.25 degrees C 0.46 1.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19120 381
SS-Chr 7BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 11 20.95 mg/d 3.07 10.17 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52591 482
SS-Chr 7BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 0.41 ml 0.02 0.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17421 381
SS-Chr 7BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 25 post-ischemic value/pre-ischemic value x 100% 85.11 % 4.36 21.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48456 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 10 66.94 mmHg 8.93 28.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45319 461
SS-Chr 7BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 11.58 ml/min/g 0.46 1.52 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46698 461
SS-Chr 7BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 25 5.18 g/kg 0.13 0.63 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46995 461
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 80.44 % 5.76 24.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44968 461
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 11 65.09 U/l 2.77 9.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42820 401
SS-Chr 7BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 11 0.27 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39621 401
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 48.95 mmHg 4.17 13.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46462 461
SS-Chr 7BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 8 1.03 g/mg 0.09 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57332 522
SS-Chr 7BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 10 1.88 mg/kg 0.39 1.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58951 526
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 11 42.27 U/l 2.86 9.5 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37721 401
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 47.89 IU/g 4.49 7.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48862 461
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.11 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59902 526
SS-Chr 7BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 113.46 % 4.89 15.45 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54035 381
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 7 29.19 mmHg 0.72 1.92 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17230 381
SS-Chr 7BN/Mcwi mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 11 113.63 mmHg 4.28 14.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20060 381
SS-Chr 7BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 8 106.4 mmHg 2.36 6.66 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19862 381
SS-Chr 7BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 67.25 ml/min 4.79 14.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20807 381
SS-Chr 7BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 11 5.73 x 1000 cells/ul 0.3 0.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36883 401
SS-Chr 7BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 88.75 mg/dl 3.05 10.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37147 401
SS-Chr 7BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 7 7.53 null 0.01 0.04 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17044 381
SS-Chr 7BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 6.16 g/dl 0.1 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37012 401
SS-Chr 7BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 144.83 U/l 6.04 20.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36429 401
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.31 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15279 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 110.74 mmHg 2.24 5.94 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 15049 381
SS-Chr 7BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 120.67 mmHg 2.9 8.69 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15088 381
SS-Chr 7BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 11 0.29 mg/dl 0.02 0.07 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52204 482
SS-Chr 7BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.87 degrees C 0.15 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13605 381
SS-Chr 7BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 13 37.36 degrees C 0.47 1.68 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13610 381
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 9 107.76 mmHg 3.41 10.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14318 381
SS-Chr 7BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 9 106.22 mmHg 6.38 19.13 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14326 381
SS-Chr 7BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 162.71 breaths/min 6.45 19.34 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16957 381
SS-Chr 7BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18033 381
SS-Chr 7BN/Mcwi body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 11 38.08 degrees C 0.14 0.45 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 17654 381
SS-Chr 7BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 55.41 mmHg 1.35 3.57 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20463 381
SS-Chr 7BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 96.23 mmHg 6.58 21.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49933 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 41.4 mmHg 3.48 11.0 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50046 461
SS-Chr 7BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 11 222.9 g 4.0 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49516 461
SS-Chr 7BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 11 0.87 x 1000 cells/ul 0.09 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38903 401
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 11 67.64 U/l 4.39 14.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42431 401
SS-Chr 7BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 21.02 pg 0.15 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42590 401
SS-Chr 7BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 11 113.73 mmol/l 0.63 2.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39162 401
SS-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 11 9.24 x 10E6 cells/ul 0.14 0.46 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39282 401
SS-Chr 7BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 8.54 x 10E6 cells/ul 0.11 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39287 401
SS-Chr 7BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 21.27 mmol/l 0.36 1.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42997 401
SS-Chr 7BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 165.13 % 5.48 16.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54470 381
SS-Chr 7BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 11 4.39 mmol/l 0.11 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43334 401
SS-Chr 7BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.24 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39724 401
SS-Chr 7BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.14 g/dl 0.05 0.16 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40600 401
SS-Chr 7BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 21.55 mg/dl 0.72 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40873 401
SS-Chr 7BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 12 0.06 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59365 526
SS-Chr 7BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 11 19.44 g/dl 0.35 1.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38013 401
SS-Chr 7BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 11 8.89 mg/dl 0.22 0.73 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37834 401
SS-Chr 7BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 11 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41411 401
SS-Chr 7BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 0.13 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59597 526
SS-Chr 7BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.53 mmol/l 0.12 0.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38116 401
SS-Chr 7BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 11 17.55 mg/dl 0.72 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41759 401
SS-Chr 7BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 31.47 % 8.26 18.46 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48572 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 129.97 mmHg 5.02 15.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48673 461
SS-Chr 7BN/Mcwi absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 7 8.51 mmHg 2.69 7.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16290 381
SS-Chr 7BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 76.39 % 7.1 18.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48801 461
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 12 30.31 ml/min/kg 1.68 5.81 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57850 526
SS-Chr 7BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -7.06 null 0.05 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55623 522
SS-Chr 7BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 11 171.0 g 3.6 11.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58352 526
SS-Chr 7BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.7 degrees C 0.16 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16858 381
SS-Chr 7BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 -8.11 null 0.06 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56110 522
SS-Chr 7BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 12 0.01 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54679 522
SS-Chr 7BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 12 17.8 ml/min/kg 1.23 4.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58630 526
SS-Chr 7BN/Mcwi hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 12 26.08 % 3.65 12.64 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55060 522
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 8 34.79 mmHg 1.21 3.42 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16063 381
SS-Chr 7BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 25 166.9 g 2.3 11.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47817 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 24 65.77 mmHg 3.84 18.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47961 461
SS-Chr 7BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 11 post-ischemic value/pre-ischemic value x 100% 48.31 % 1.42 4.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47122 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 11 344.37 beats/min 74.76 247.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45193 461
SS-Chr 7BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 10 19.23 mEq/d 1.2 3.81 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52742 482
SS-Chr 7BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20619 381
SS-Chr 7BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.04 0.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13969 381
SS-Chr 7BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 11 1.19 mEq/d 0.07 0.24 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52938 482
SS-Chr 7BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 11 0.32 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47445 461
SS-Chr 7BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 9 34.54 mmHg 0.56 1.69 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16057 381
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 11 47.28 mmHg 7.76 25.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45315 461
SS-Chr 7BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 24 45.06 mmHg 5.25 25.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47956 461
SS-Chr 7BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 25 43.16 mmHg 2.21 11.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48078 461
SS-Chr 7BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 11 -7.1 null 0.04 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55630 522
SS-Chr 7BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 11 80.64 U/l 7.12 23.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42815 401
SS-Chr 7BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 11 6.27 x 1000 cells/ul 0.27 0.91 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39899 401
SS-Chr 7BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 13 173.25 % 7.97 28.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54474 381
SS-Chr 7BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 11 108.27 mg/dl 1.47 4.86 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38447 401
SS-Chr 7BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 135.84 % 11.04 34.92 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54375 381
SS-Chr 7BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 18 5.54 mmHg 0.2 0.86 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49227 461
SS-Chr 7BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 25 977.8 s 28.88 144.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50164 461
SS-Chr 7BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 11 0.13 x 1000 cells/ul 0.02 0.08 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40308 401
SS-Chr 7BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 11 1.22 g 0.05 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45450 461
SS-Chr 7BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 11 55.45 U/l 2.41 7.99 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40759 401
SS-Chr 7BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1238.8 s 44.37 140.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50276 461
SS-Chr 7BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 258.98 beats/min 8.46 26.75 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47631 461
SS-Chr 7BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 11 15.82 mmol/l 1.1 3.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42107 401
SS-Chr 7BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 11 43.84 % 0.4 1.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41316 401
SS-Chr 7BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 11 0.24 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57915 526