Phenominer Database Results (406 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
SS-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 100.36 breaths/min 5.73 18.12 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18473 381
SS-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 157.1 breaths/min 5.34 16.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16974 381
SS-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 182.12 breaths/min 10.94 34.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16977 381
SS-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 17 76.18 mg/dl 3.38 13.93 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37159 401
SS-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 77.62 ml/min 5.6 17.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14566 381
SS-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.26 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15463 381
SS-Chr 11BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 -0.17 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15735 381
SS-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 104.02 breaths/min 6.47 20.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15001 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 15 161.86 mmHg 5.89 22.8 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52854 482
SS-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 14 1.11 ng/ml/h 0.26 0.96 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52460 482
SS-Chr 11BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 14 0.34 ng/ml/h 0.09 0.33 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52462 482
SS-Chr 11BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 11 1.7 ml/min 0.22 0.74 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52166 482
SS-Chr 11BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 130.11 mmHg 6.01 14.71 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13504 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 -6.79 mmHg 0.72 1.76 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19652 381
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 436.02 beats/min 34.89 85.45 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17527 381
SS-Chr 11BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 12 145.75 mmol/l 0.76 2.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36531 401
SS-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 17 19.82 mmol/l 0.8 3.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42124 401
SS-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 8.45 x 10E6 cells/ul 0.18 0.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39299 401
SS-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 15 142.47 mmol/l 0.52 2.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39453 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 32.32 g/dl 0.12 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39842 401
SS-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 171.89 % 4.51 13.54 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54487 381
SS-Chr 11BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 13 24.23 mmol/l 0.5 1.79 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43178 401
SS-Chr 11BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 13 21.0 mmol/l 0.51 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43037 401
SS-Chr 11BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 12 3.92 g/dl 0.05 0.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40448 401
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 10 1.06 mg/kg 0.13 0.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59205 526
SS-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 15 8.98 x 1000 cells/ul 0.46 1.79 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40991 401
SS-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 17 9.22 mg/dl 0.44 1.81 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37656 401
SS-Chr 11BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 13 106.62 mmol/l 0.27 0.96 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40053 401
SS-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 43.88 % 0.35 1.26 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41349 401
SS-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 15 21.93 mmol/l 1.06 4.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38326 401
SS-Chr 11BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 12 102.08 mg/dl 1.75 6.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38474 401
SS-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 0.86 g 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45466 461
SS-Chr 11BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 12 59.99 fl 0.13 0.47 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38688 401
SS-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 289.7 g 7.7 24.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55217 522
SS-Chr 11BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 11 197.5 g 2.6 8.7 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55446 522
SS-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.64 degrees C 0.48 1.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16635 381
SS-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.45 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16536 381
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.47 null 0.04 0.17 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58178 526
SS-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 2.45 E-7mole 0.0 0.0 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56558 522
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.11 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59929 526
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 11 0.13 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59935 526
SS-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54938 522
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 12.78 ml/min/kg 1.65 5.22 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60035 526
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82 days-99 days 6 33.09 mmHg 1.33 3.27 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16087 381
SS-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.44 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17433 381
SS-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 25 5.31 g/kg 0.14 0.72 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45654 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 0.31 IU/g 0.05 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47339 461
SS-Chr 11BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 62.0 mmHg 4.83 14.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48095 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 20 4.93 mmHg 0.21 0.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47258 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 52.41 mmHg 5.05 21.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45331 461
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.37 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15299 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 45.13 ml/min 3.15 9.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18728 381
SS-Chr 11BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 13 147.31 mmol/l 0.36 1.32 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36537 401
SS-Chr 11BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 19 0.99 mEq/d 0.07 0.3 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52952 482
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 350.62 beats/min 18.91 50.03 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 17523 381
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 62.66 % 9.1 20.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46381 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 5 122.71 mmHg 7.21 16.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46812 461
SS-Chr 11BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 4.62 g/kg 0.12 0.38 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47029 461
SS-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.43 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16539 381
SS-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 15 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41712 401
SS-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 14 0.44 x 1000 cells/ul 0.06 0.22 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39739 401
SS-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 15 7.53 x 1000 cells/ul 0.37 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41568 401
SS-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 0.03 umol/l 0.01 0.04 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54712 522
SS-Chr 11BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 12 0.24 x 1000 cells/ul 0.05 0.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40335 401
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 51.2 mmHg 2.86 13.42 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46481 461
SS-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 160.62 % 7.13 21.38 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53696 381
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 18 113.28 mmHg 4.72 20.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48688 461
SS-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 15 3.94 g/dl 0.07 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42298 401
SS-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 -7.9 null 0.11 0.36 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55307 522
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 52.9 % 0.89 3.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39056 401
SS-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 0.26 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15460 381
SS-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 173.98 % 10.84 34.27 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54283 381
SS-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17068 381
SS-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during 2-3 min hypoxia/control during standard conditions 151.8 % 11.61 34.82 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13746 381
SS-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 0.05 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19804 381
SS-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 6 128.65 mmHg 3.99 9.78 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19885 381
SS-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 6 432.36 beats/min 27.78 68.04 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20945 381
SS-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 89.06 breaths/min 5.66 16.98 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18476 381
SS-Chr 11BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 98.3 breaths/min 1.95 5.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14998 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 14 162.26 mmHg 3.49 13.07 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52856 482
SS-Chr 11BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 19 87.31 mg/d 7.52 32.76 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52705 482
SS-Chr 11BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 21 15.6 mEq/d 1.58 7.24 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52758 482
SS-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 14 0.34 mg/dl 0.02 0.09 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52217 482
SS-Chr 11BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.86 degrees C 0.71 2.12 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13622 381
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 257.21 % 17.48 52.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14261 381
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 309.54 % 23.12 73.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14264 381
SS-Chr 11BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 12 9.75 mg/dl 0.12 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36800 401
SS-Chr 11BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 13 6.05 g/dl 0.08 0.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37245 401
SS-Chr 11BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 0.89 g 0.03 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49122 461
SS-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 -0.21 degrees C 0.19 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20372 381
SS-Chr 11BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 9 816.78 s 20.49 61.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50181 461
SS-Chr 11BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 798.5 s 28.13 88.95 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50184 461
SS-Chr 11BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 15 18.2 mmol/l 0.91 3.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42127 401
SS-Chr 11BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 13 0.28 mg/dl 0.03 0.11 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42693 401
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 118.04 % 6.46 20.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54388 381
SS-Chr 11BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 12 22.0 mmol/l 0.41 1.41 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43172 401
SS-Chr 11BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 13 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42930 401
SS-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 16 0.37 mg/dl 0.03 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39638 401
SS-Chr 11BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 13 4.54 mmol/l 0.08 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43374 401
SS-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 15 0.94 x 1000 cells/ul 0.1 0.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43289 401
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.26 mg/kg 0.2 0.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59211 526
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 11 0.04 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59405 526
SS-Chr 11BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 12 147.33 mg/dl 2.89 10.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41235 401
SS-Chr 11BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 13 152.15 mg/dl 3.64 13.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41241 401
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 14 1.05 g/kg 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59501 526
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 12 38.5 U/l 2.97 10.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37748 401
SS-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 15 5.19 mmol/l 0.13 0.52 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38131 401
SS-Chr 11BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 13 18.85 mg/dl 0.59 2.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41799 401
SS-Chr 11BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 985.89 s 20.46 61.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46610 461
SS-Chr 11BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 25 0.91 g 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45469 461
SS-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 15 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41933 401
SS-Chr 11BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 190.6 g 2.9 9.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55211 522
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 18.82 ml/min/kg 1.0 4.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57660 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 30.98 ml/min/kg 1.25 5.14 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57862 526
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 14 0.2 null 0.01 0.03 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57948 526
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 76.65 ml/min/kg 6.38 25.51 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58061 526
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 51.78 ml/min/kg 3.45 14.21 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58064 526
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 16 0.43 null 0.03 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58175 526
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 82.11 % 5.21 15.62 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54812 522
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 79.75 % 6.46 18.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54818 522
SS-Chr 11BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.45 ml 0.03 0.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17436 381
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 74.44 % 5.59 16.76 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57256 522
SS-Chr 11BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 236.8 g 3.2 10.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47851 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 25 11.17 ml/min/g 0.52 2.6 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46717 461
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 post-ischemic value/pre-ischemic value x 100% 63.44 % 2.04 4.56 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46384 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 5.52 mmHg 0.16 0.73 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47261 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 post-ischemic value/pre-ischemic value x 100% 52.71 % 3.79 17.78 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47141 461
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 113.8 % 2.7 8.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53947 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 -6.27 mmHg 0.87 2.13 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19656 381
SS-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18045 381
SS-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 150.17 % 10.37 31.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54281 381
SS-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 176.81 breaths/min 8.14 25.75 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17177 381
SS-Chr 11BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 108.69 mmHg 2.12 5.2 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18891 381
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 32.52 g/dl 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37375 401
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 303.19 % 19.61 62.01 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19277 381
SS-Chr 11BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 10 66.0 mmHg 3.33 10.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48098 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 6.79 ml/min/g 0.24 0.77 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46266 461
SS-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 post-ischemic value/pre-ischemic value x 100% 93.01 % 3.14 13.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48356 461
SS-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 -6.85 null 0.1 0.3 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55663 522
SS-Chr 11BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 16 6.42 x 1000 cells/ul 0.52 2.1 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41565 401
SS-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.84 null 0.04 0.11 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56953 522
SS-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 36.85 degrees C 0.37 1.17 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16875 381
SS-Chr 11BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 16 0.82 x 1000 cells/ul 0.13 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43286 401
SS-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 14 153.43 mg/dl 6.31 23.61 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38595 401
SS-Chr 11BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 12 6.36 x 1000 cells/ul 0.56 1.94 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39926 401
SS-Chr 11BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 13 8.58 x 1000 cells/ul 0.6 2.17 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39932 401
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 121.55 mmHg 6.44 17.03 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45566 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 17 0.29 IU/g 0.13 0.54 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47475 461
SS-Chr 11BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 13 0.19 x 1000 cells/ul 0.06 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40341 401
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 42.38 % 3.74 13.47 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48588 461
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 17 52.75 % 1.12 4.6 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39053 401
SS-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 15 22.4 mg/dl 0.92 3.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40893 401
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 13 196.08 U/l 7.63 27.49 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37497 401
SS-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 44.4 % 0.41 1.42 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41343 401
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 114.76 breaths/min 4.72 14.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14857 381
SS-Chr 11BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 450.49 beats/min 23.65 52.88 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14721 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 127.9 mmHg 8.01 21.21 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14350 381
SS-Chr 11BN/Mcwi mean arterial blood pressure air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 117.84 mmHg 4.44 9.92 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 13508 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 112.88 % 3.86 11.58 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53949 381
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 17 123.12 U/l 4.68 19.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36441 401
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 15 214.67 U/l 9.27 35.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36444 401
SS-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82 days-99 days 7 142.04 mmHg 7.05 18.65 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15112 381
SS-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 133.49 mmHg 3.36 8.22 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15116 381
SS-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 21 42.57 mg/d 8.71 39.93 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52607 482
SS-Chr 11BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 15 401.61 beats/min 7.22 27.95 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52656 482
SS-Chr 11BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 14 378.79 beats/min 10.47 39.16 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52658 482
SS-Chr 11BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 21 1.32 mEq/d 0.1 0.45 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52954 482
SS-Chr 11BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 14 2.51 ml/min 0.24 0.9 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52168 482
SS-Chr 11BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 21 121.19 mg/d 15.81 72.45 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52707 482
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.31 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13986 381
SS-Chr 11BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 133.87 % 7.23 22.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13743 381
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount female 82 days-99 days 6 26.31 mmHg 1.01 2.47 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17260 381
SS-Chr 11BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 198.3 g 2.4 7.7 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17880 381
SS-Chr 11BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82 days-99 days 6 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20643 381
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 -42.72 mmHg 2.36 5.77 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19483 381
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 32.49 g/dl 0.14 0.49 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37369 401
SS-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 24 1082.46 s 23.47 114.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50291 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 16.97 % 3.19 9.02 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49458 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 10 22.06 % 2.36 7.47 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49461 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 95.98 mmHg 3.9 18.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49952 461
SS-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 17 108.88 mmol/l 1.32 5.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39179 401
SS-Chr 11BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 14.43 g/dl 0.1 0.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40143 401
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 15 52.9 % 0.89 3.43 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59322 526
SS-Chr 11BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 15 10.06 mg/dl 0.52 2.01 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37659 401
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 15 54.0 U/l 4.14 16.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40779 401
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 20 1.49 g/kg 0.05 0.22 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59719 526
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 17 1.19 g/kg 0.04 0.15 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59722 526
SS-Chr 11BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 12 8.62 mg/dl 0.2 0.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37868 401
SS-Chr 11BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 13 9.37 mg/dl 0.2 0.71 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37874 401
SS-Chr 11BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 13 2.37 g/dl 0.1 0.35 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41074 401
SS-Chr 11BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 17 18.88 mmol/l 1.0 4.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38323 401
SS-Chr 11BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 12 7.4 x 10E6 cells/ul 0.07 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42010 401
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 115.1 mmHg 3.26 7.99 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45569 461
SS-Chr 11BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 16 post-ischemic value/pre-ischemic value x 100% 36.89 % 2.7 10.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48591 461
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 14.0 ml/min/kg 0.41 1.7 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57663 526
SS-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.87 g/mg 0.1 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57366 522
SS-Chr 11BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 10 71.3 % 6.47 20.47 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57262 522
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 8 28.96 IU/g 2.67 7.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48886 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 35.54 IU/g 2.07 6.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48892 461
SS-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 25.29 ml/min 1.49 4.47 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16210 381
SS-Chr 11BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 36.99 degrees C 0.32 0.96 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16638 381
SS-Chr 11BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 12 179.0 g 2.0 6.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58379 526
SS-Chr 11BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 14 229.6 g 8.0 29.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58385 526
SS-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 27.24 ml/min 1.91 6.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16753 381
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 17 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58554 526
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 16 1.02 mg/kg 0.19 0.76 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58968 526
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82 days-99 days 6 33.25 mmHg 1.49 3.66 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 16091 381
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 24.59 IU/g 4.83 15.27 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45989 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 14 23.08 IU/g 4.09 15.31 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45993 461
SS-Chr 11BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 23 6.17 g/kg 0.21 0.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45648 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 44.55 mmHg 4.2 11.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47763 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 72.36 % 4.16 13.16 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46130 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 22 5.57 ml/min/g 0.32 1.5 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44782 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 6.88 ml/min/g 0.51 1.43 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46263 461
SS-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 272.34 beats/min 4.39 13.17 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48259 461
SS-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 107.37 % 3.29 8.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44983 461
SS-Chr 11BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 1.1 g 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49125 461
SS-Chr 11BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 19 13.54 mEq/d 1.29 5.61 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52756 482
SS-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait male 82 days-99 days 5 466.52 beats/min 9.07 20.29 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15951 381
SS-Chr 11BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 9 146.63 breaths/min 8.77 26.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17174 381
SS-Chr 11BN/Mcwi mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 6 125.86 mmHg 4.39 10.74 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14354 381
SS-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 17 9.27 mg/dl 0.1 0.43 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36686 401
SS-Chr 11BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 15 9.67 mg/dl 0.09 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36689 401
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 %change=VE during7-9 min hypercapnia/control during standard conditions 140.67 % 9.71 29.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18609 381
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 %change=VE during 2-3 min hypercapnia/control during standard conditions 278.22 % 7.9 23.69 stop flow air displacement plethysmography 0 0 Moms and pups used in studies were fed Teklad 19274 381
SS-Chr 11BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 post-ischemic value/pre-ischemic value x 100% 95.27 % 1.69 5.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48471 461
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 53.46 mmHg 2.62 8.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47766 461
SS-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.81 null 0.05 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56947 522
SS-Chr 11BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 12 0.31 mg/dl 0.03 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42687 401
SS-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 21 779.76 s 30.21 138.44 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49360 461
SS-Chr 11BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 12 0.1 mg/dl 0.0 0.0 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42924 401
SS-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 30.57 ml/min 2.43 7.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16756 381
SS-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 9 37.64 degrees C 0.3 0.91 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16878 381
SS-Chr 11BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 12 109.17 U/l 6.41 22.22 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37491 401
SS-Chr 11BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 14.27 g/dl 0.1 0.37 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40149 401
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 43.33 mmHg 4.19 18.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46478 461
SS-Chr 11BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 17 145.12 mg/dl 5.59 23.04 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38592 401
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 20 164.4 g 4.9 22.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59124 526
SS-Chr 11BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 989.0 s 29.44 93.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46613 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 25 252.09 beats/min 7.11 35.54 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47646 461
SS-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 17 62.42 fl 0.4 1.64 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38807 401
SS-Chr 11BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 17 3.96 g/dl 0.07 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42295 401
SS-Chr 11BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 17 23.65 mg/dl 1.41 5.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40890 401
SS-Chr 11BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 13 0.34 mg/dl 0.03 0.1 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52215 482
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 129.67 % 6.77 20.3 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53817 381
SS-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 63.4 ml/min 2.29 6.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20824 381
SS-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 79.39 ml/min 6.86 21.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20827 381
SS-Chr 11BN/Mcwi mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82 days-99 days 5 112.35 mmHg 7.87 17.59 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 19889 381
SS-Chr 11BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 9 -0.02 degrees C 0.28 0.83 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15732 381
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 98.76 % 3.0 9.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54048 381
SS-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 170.29 % 6.47 20.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54149 381
SS-Chr 11BN/Mcwi heart rate air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 419.52 beats/min 14.53 35.58 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 14717 381
SS-Chr 11BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.16 degrees C 0.23 0.73 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13625 381
SS-Chr 11BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 300.5 g 3.7 11.5 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17883 381
SS-Chr 11BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 12 6.12 g/dl 0.04 0.13 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37239 401
SS-Chr 11BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 13 9.87 mg/dl 0.13 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36806 401
SS-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.33 degrees C 0.16 0.49 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19135 381
SS-Chr 11BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 9 36.88 degrees C 0.76 2.27 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19132 381
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.46 mmHg 0.28 0.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49242 461
SS-Chr 11BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 24 862.88 s 30.1 147.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49363 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 20 14.65 % 2.14 9.58 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49759 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 19 95.74 mmHg 5.3 23.09 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49949 461
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 24 140.8 g 2.5 12.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49550 461
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 12 67.33 U/l 4.51 15.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42458 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 20.12 pg 0.11 0.45 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42607 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 19.75 pg 0.13 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42610 401
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 16 72.75 U/l 4.61 18.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42832 401
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 15 82.47 U/l 7.16 27.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42835 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 32.24 g/dl 0.1 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39839 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 13 18.77 pg 0.1 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40245 401
SS-Chr 11BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 13 3.68 g/dl 0.08 0.27 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40454 401
SS-Chr 11BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 177.9 % 9.86 31.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53698 381
SS-Chr 11BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 12 4.05 mmol/l 0.1 0.35 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43368 401
SS-Chr 11BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 12 106.42 mmol/l 0.51 1.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40047 401
SS-Chr 11BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 17 52.75 % 1.12 4.6 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59319 526
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 17 41.24 U/l 3.81 15.7 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40776 401
SS-Chr 11BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 17 8.01 x 1000 cells/ul 0.79 3.27 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40988 401
SS-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 15 2.11 g/dl 0.09 0.33 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40615 401
SS-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 15 17.08 g/dl 0.26 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38033 401
SS-Chr 11BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 17 4.51 mmol/l 0.11 0.45 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38128 401
SS-Chr 11BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 13 0.0 x 1000 cells/ul 0.0 0.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41451 401
SS-Chr 11BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 13 89.54 mg/dl 1.43 5.16 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38480 401
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 111.7 mmHg 6.77 26.2 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48685 461
SS-Chr 11BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 13 57.7 fl 0.22 0.78 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38694 401
SS-Chr 11BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 26.86 ml/min 3.0 9.48 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16213 381
SS-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 12 44.4 % 0.41 1.42 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57528 526
SS-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 10 1.3 E-7mole 0.28 0.9 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55926 522
SS-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 11 2.05 E-7mole 0.45 1.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55932 522
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 17 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58551 526
SS-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.73 null 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56137 522
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 20 0.35 null 0.03 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58795 526
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 0.37 null 0.02 0.07 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59813 526
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 65.32 mmHg 4.41 13.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47976 461
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 65.72 % 6.09 17.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46127 461
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 10 0.32 IU/g 0.03 0.11 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47345 461
SS-Chr 11BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 93.06 % 3.58 10.13 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48468 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 237.4 beats/min 18.95 90.87 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45212 461
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 41.78 ml/min 2.27 6.8 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20274 381
SS-Chr 11BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 9 -0.66 degrees C 0.42 1.26 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20375 381
SS-Chr 11BN/Mcwi absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 0.05 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19808 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 30.86 ml/min 2.17 6.88 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20271 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.27 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15296 381
SS-Chr 11BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 13 6.79 x 1000 cells/ul 0.79 2.85 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36916 401
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 116.23 breaths/min 3.8 11.39 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18331 381
SS-Chr 11BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 35.99 ml/min 2.51 7.94 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18725 381
SS-Chr 11BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 post-ischemic value/pre-ischemic value x 100% 67.56 % 4.46 19.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47138 461
SS-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 265.07 beats/min 5.75 18.18 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48262 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 22 44.85 mmHg 3.96 18.55 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45334 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 23 11.44 ml/min/g 0.77 3.7 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46714 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 10.66 ml/min/g 0.71 2.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46931 461
SS-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 11 1.59 g/mg 0.06 0.2 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55820 522
SS-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 21 45.19 mmHg 4.03 18.45 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50058 461
SS-Chr 11BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 13 52.54 U/l 1.83 6.59 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37754 401
SS-Chr 11BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.63 E-7mole 0.18 0.55 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56552 522
SS-Chr 11BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 10 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59399 526
SS-Chr 11BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 11 309.9 g 6.4 21.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55452 522
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 17 0.13 mmHg x min x kg x ml-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59609 526
SS-Chr 11BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 0.13 mmHg x min x kg x ml-1 0.0 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59612 526
SS-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 6 446.88 beats/min 8.86 21.7 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 15947 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 112.93 breaths/min 3.73 11.18 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14860 381
SS-Chr 11BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 69.76 ml/min 3.23 9.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14563 381
SS-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 9 175.04 % 6.7 20.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54147 381
SS-Chr 11BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.39 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13989 381
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.96 % 7.35 23.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53815 381
SS-Chr 11BN/Mcwi heart rate control condition PhysGen Respiratory data heart pumping trait female 82 days-99 days 7 397.47 beats/min 26.42 69.9 vascular fluid filled catheter 0 Moms and pups used in studies were fed Teklad 20941 381
SS-Chr 11BN/Mcwi blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.51 null 0.02 0.04 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20647 381
SS-Chr 11BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 12 5.58 x 1000 cells/ul 0.51 1.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36910 401
SS-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 17 5.89 g/dl 0.13 0.53 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37024 401
SS-Chr 11BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 15 6.05 g/dl 0.13 0.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37027 401
SS-Chr 11BN/Mcwi partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 105.33 mmHg 3.1 7.6 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 18887 381
SS-Chr 11BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 15 78.73 mg/dl 2.57 9.95 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37162 401
SS-Chr 11BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 5.35 mmHg 0.23 0.57 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49239 461
SS-Chr 11BN/Mcwi absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 -47.97 mmHg 3.08 7.53 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 19487 381
SS-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 8 249.74 beats/min 8.38 23.71 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49007 461
SS-Chr 11BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 10 251.9 beats/min 3.89 12.29 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49010 461
SS-Chr 11BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 25 44.2 mmHg 2.96 14.82 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50061 461
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 25 172.4 g 5.6 28.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49556 461
SS-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82 days-99 days 6 62.62 mmHg 2.21 5.42 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20495 381
SS-Chr 11BN/Mcwi partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82 days-99 days 6 60.73 mmHg 1.9 4.66 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 20499 381
SS-Chr 11BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 13 0.8 x 1000 cells/ul 0.1 0.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38943 401
SS-Chr 11BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 12 0.52 x 1000 cells/ul 0.07 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38937 401
SS-Chr 11BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 15 8.65 x 10E6 cells/ul 0.13 0.52 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39302 401
SS-Chr 11BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 17 143.12 mmol/l 1.49 6.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39450 401
SS-Chr 11BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 15 107.67 mmol/l 0.44 1.72 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39182 401
SS-Chr 11BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 9 135.12 % 10.11 30.33 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54390 381
SS-Chr 11BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 16 0.22 x 1000 cells/ul 0.03 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39736 401
SS-Chr 11BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 177.11 % 6.28 19.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54489 381
SS-Chr 11BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 15 0.34 mg/dl 0.03 0.12 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39641 401
SS-Chr 11BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 12 19.5 pg 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40239 401
SS-Chr 11BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 14 1.49 mg/kg 0.23 0.86 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58971 526
SS-Chr 11BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 17 1.93 g/dl 0.11 0.44 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40612 401
SS-Chr 11BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 12 1.15 g/kg 0.04 0.14 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59495 526
SS-Chr 11BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 17 16.98 g/dl 0.34 1.4 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38030 401
SS-Chr 11BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 12 20.67 mg/dl 0.8 2.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41793 401
SS-Chr 11BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 13 7.61 x 10E6 cells/ul 0.08 0.29 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42016 401
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 22 259.99 beats/min 6.46 30.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47643 461
SS-Chr 11BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 17 0.12 mg/dl 0.01 0.06 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41930 401
SS-Chr 11BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 13 43.88 % 0.35 1.26 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57534 526
SS-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 11 -7.85 null 0.14 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55313 522
SS-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 18 post-ischemic value/pre-ischemic value x 100% 82.25 % 2.64 11.21 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48820 461
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 56.17 ml/min/kg 6.62 20.94 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58267 526
SS-Chr 11BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 10 43.13 ml/min/kg 2.93 9.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58273 526
SS-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.92 g/mg 0.06 0.18 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55826 522
SS-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54944 522
SS-Chr 11BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 10 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54706 522
SS-Chr 11BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 -7.8 null 0.12 0.39 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56143 522
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 10 20.18 ml/min/kg 2.08 6.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58664 526
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 17 0.34 null 0.02 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58798 526
SS-Chr 11BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.44 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59819 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 11.5 ml/min/kg 0.85 2.55 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 60041 526
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 67.51 mmHg 7.4 20.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47973 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 21 122.5 mmHg 4.58 20.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45793 461
SS-Chr 11BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 5 111.83 mmHg 3.22 7.19 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46815 461
SS-Chr 11BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 10 171.6 g 1.8 5.6 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47845 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 10 118.77 mmHg 3.17 10.02 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44880 461
SS-Chr 11BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 23 post-ischemic value/pre-ischemic value x 100% 97.61 % 10.18 48.83 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48359 461
SS-Chr 11BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 108.65 % 4.64 13.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54050 381
SS-Chr 11BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 9 0.34 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18048 381
SS-Chr 11BN/Mcwi partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood gas amount male 82 days-99 days 6 26.98 mmHg 0.84 2.06 automated blood gas analysis using a Bayer analyzer 0 Moms and pups used in studies were fed Teklad 17264 381
SS-Chr 11BN/Mcwi blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82 days-99 days 6 7.56 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer 0 Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 17072 381
SS-Chr 11BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.27 breaths/min 4.33 13.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18328 381
SS-Chr 11BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 116.16 % 9.35 29.56 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18606 381
SS-Chr 11BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 19 27.04 mg/d 5.32 23.2 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52605 482
SS-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 101.15 % 6.39 16.92 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44980 461
SS-Chr 11BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 19 236.88 beats/min 7.82 34.08 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45209 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 15 116.72 mmHg 6.69 25.91 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45790 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 10 9.69 ml/min/g 0.7 2.21 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46934 461
SS-Chr 11BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 10 5.21 g/kg 0.17 0.54 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 47023 461
SS-Chr 11BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 20 7.85 ml/min/g 0.68 3.05 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44779 461
SS-Chr 11BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 112.06 mmHg 9.25 26.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44877 461
SS-Chr 11BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 12 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41445 401
SS-Chr 11BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 12 21.42 mmol/l 0.36 1.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43031 401
SS-Chr 11BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.92 null 0.09 0.26 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55657 522
SS-Chr 11BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 17 0.02 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41709 401
SS-Chr 11BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 17 234.4 g 6.4 26.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59127 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 19.69 ml/min/kg 1.86 5.59 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58670 526
SS-Chr 11BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 25 0.36 IU/g 0.12 0.58 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47481 461
SS-Chr 11BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 21 1024.95 s 25.42 116.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50288 461
SS-Chr 11BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 22 19.43 % 2.56 11.99 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49762 461
SS-Chr 11BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 13 post-ischemic value/pre-ischemic value x 100% 83.85 % 3.55 12.78 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48817 461
SS-Chr 11BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 15 61.13 fl 0.53 2.05 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38810 401
SS-Chr 11BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 10 0.81 g/mg 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57372 522
SS-Chr 11BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 12 2.2 g/dl 0.05 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41068 401
SS-Chr 11BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 12 0.17 null 0.01 0.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57942 526
SS-Chr 11BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 17 22.66 ml/min/kg 0.7 2.9 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57865 526
SS-Chr 11BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 13 87.92 U/l 5.48 19.74 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42464 401