Phenominer Database Results (372 results)

 
 
How to display a graph
Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Duration Post Insult Time Value Method Notes Clinical Measurement Notes Experiment Notes Record ID Study ID
FHH-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 111.18 breaths/min 7.1 22.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14922 381
FHH-Chr 2BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 132.85 % 7.17 22.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54203 381
FHH-Chr 2BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 133.54 % 8.32 26.31 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54209 381
FHH-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 137.56 % 8.88 28.09 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13672 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.24 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13915 381
FHH-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 79.25 mg/dl 3.54 10.03 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37089 401
FHH-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity female 80 days-99 days 5 0.4 ng/ml/h 0.07 0.16 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52885 482
FHH-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait male 80 days-99 days 4 2.06 ml/min 0.53 1.06 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52365 482
FHH-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount female 80 days-99 days 7 88.33 mg/d 17.59 46.54 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52101 482
FHH-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait male 80 days-99 days 5 433.8 beats/min 7.27 16.25 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52510 482
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 156.15 breaths/min 9.77 30.91 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14781 381
FHH-Chr 2BN/Mcwi body weight control condition PhysGen Respiratory data body mass female 82 days-99 days 10 154.4 g 5.6 17.7 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17804 381
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 208.0 U/l 6.44 18.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37437 401
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 113.59 % 7.67 24.24 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18535 381
FHH-Chr 2BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 0.73 g 0.04 0.11 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49052 461
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 36.05 ml/min 3.83 12.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20195 381
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 180.35 % 14.68 46.43 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19203 381
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 997.6 s 39.86 126.04 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49286 461
FHH-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 108.0 mmol/l 0.82 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39104 401
FHH-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 9.95 x 10E6 cells/ul 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39229 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.25 g/dl 0.15 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39769 401
FHH-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.3 x 1000 cells/ul 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39661 401
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 128.9 g 4.2 13.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59049 526
FHH-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 7 10.9 mg/dl 0.35 0.94 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37581 401
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.87 g/kg 0.02 0.08 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59644 526
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 61.25 U/l 7.37 20.85 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37710 401
FHH-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.14 x 1000 cells/ul 0.04 0.12 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41634 401
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 212.35 beats/min 14.27 40.37 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47574 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 90.92 mmHg 6.66 16.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45491 461
FHH-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.78 null 0.08 0.25 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55269 522
FHH-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 1.37 g/mg 0.26 0.78 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57312 522
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 9 0.32 null 0.02 0.06 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57888 526
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 56.16 ml/min/kg 4.14 12.42 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57986 526
FHH-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.76 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16559 381
FHH-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.47 degrees C 0.16 0.5 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16799 381
FHH-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 1.39 E-7mole 0.2 0.57 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55888 522
FHH-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 -7.72 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56099 522
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 9 0.04 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58481 526
FHH-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54652 522
FHH-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 2.02 E-7mole 0.37 1.1 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56498 522
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 8 2.88 mg/kg 0.7 1.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58893 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 16.29 ml/min/kg 1.09 3.27 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59981 526
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 3.16 ml/min/g 0.52 1.55 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44705 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 2.59 ml/min/g 0.2 0.56 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 44710 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 10 9.42 ml/min/g 0.6 1.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46640 461
FHH-Chr 2BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49 days-63 days 8 5.38 g/kg 0.21 0.59 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46969 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 77.63 % 6.4 16.94 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48282 461
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 99.18 % 5.77 18.25 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53869 381
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 100.7 % 8.57 27.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53875 381
FHH-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.25 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17974 381
FHH-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 4.86 g/dl 0.08 0.21 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36949 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 32.59 g/dl 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37315 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 32.94 g/dl 0.15 0.43 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37331 401
FHH-Chr 2BN/Mcwi percent change in ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypoxia/control during standard conditions 145.18 % 11.18 35.36 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13667 381
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77 days-91 days 8 262.0 U/l 8.87 25.1 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36366 401
FHH-Chr 2BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.68 mg/dl 0.22 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36746 401
FHH-Chr 2BN/Mcwi urine total protein excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data total urine protein amount male 80 days-99 days 5 393.33 mg/d 89.68 200.53 automated urine total protein analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52120 482
FHH-Chr 2BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 142.88 mmol/l 0.44 1.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36477 401
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 10 0.25 IU/g 0.04 0.12 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47426 461
FHH-Chr 2BN/Mcwi body weight control condition PhysGen Cardiac data body mass female 49 days-63 days 8 135.1 g 4.7 13.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47791 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 85.99 mmHg 6.81 16.68 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46737 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 9 7.47 IU/g 1.32 3.96 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45953 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 7.1 IU/g 0.77 2.19 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 45963 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 10.06 ml/min/g 1.15 2.82 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46857 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 81.54 mmHg 12.12 29.7 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44802 461
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 6 5.06 % 3.11 7.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49383 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 9 200.32 beats/min 12.22 36.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47569 461
FHH-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.65 g/dl 0.12 0.33 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40542 401
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 28.17 ml/min/kg 2.19 6.57 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58610 526
FHH-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 17.32 % 4.06 10.74 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48519 461
FHH-Chr 2BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 0.4 x 1000 cells/ul 0.09 0.25 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38883 401
FHH-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 56.98 fl 0.36 1.02 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38737 401
FHH-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 8 4.71 mmol/l 0.17 0.48 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38053 401
FHH-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount male 80 days-99 days 5 1.34 mEq/d 0.07 0.15 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52318 482
FHH-Chr 2BN/Mcwi creatinine clearance controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data glomerular filtration trait female 80 days-99 days 5 1.71 ml/min 0.2 0.44 urine creatinine analysis 0 Moms were fed Teklad, pups used in studies were fed Dyets 52346 482
FHH-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount female 80 days-99 days 7 24.31 mg/d 6.0 15.88 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52393 482
FHH-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait female 80 days-99 days 5 156.33 mmHg 11.05 24.71 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52538 482
FHH-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 116.38 breaths/min 6.91 21.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14927 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 156.24 breaths/min 8.84 27.96 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14786 381
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 191.57 % 16.71 52.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14185 381
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 120.14 % 7.05 22.29 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53743 381
FHH-Chr 2BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.24 g/dl 0.14 0.39 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37201 401
FHH-Chr 2BN/Mcwi serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.43 mg/dl 0.24 0.69 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36762 401
FHH-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77 days-91 days 8 9.21 mg/dl 0.07 0.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36616 401
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 40.62 ml/min 4.8 15.17 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18649 381
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 8 8.19 % 2.82 7.98 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49388 461
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 88.5 U/l 7.11 20.11 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42404 401
FHH-Chr 2BN/Mcwi serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 109.0 mmol/l 1.1 3.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39109 401
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 97.0 U/l 2.19 6.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42762 401
FHH-Chr 2BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 18.5 mmol/l 2.44 6.91 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43134 401
FHH-Chr 2BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77 days-91 days 8 0.17 x 1000 cells/ul 0.04 0.11 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40281 401
FHH-Chr 2BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 142.23 % 7.32 23.14 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53624 381
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77 days-91 days 10 1.1 g/kg 0.03 0.09 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59441 526
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 36.25 U/l 2.4 6.8 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40701 401
FHH-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.27 g/dl 0.34 0.98 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37960 401
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 0.94 g/kg 0.03 0.1 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59457 526
FHH-Chr 2BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77 days-91 days 8 0.01 x 1000 cells/ul 0.01 0.03 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41391 401
FHH-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 173.14 mg/dl 7.77 20.56 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38517 401
FHH-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 20.63 mmol/l 0.98 2.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38248 401
FHH-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 7.62 g/kg 0.31 0.97 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45594 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 131.27 mmHg 9.31 26.33 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48616 461
FHH-Chr 2BN/Mcwi mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 58.76 fl 0.32 0.92 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38732 401
FHH-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 39.51 % 1.32 3.73 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57474 526
FHH-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 42.44 % 1.18 3.34 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 57490 526
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 62.73 % 3.46 9.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48743 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 6 9.1 IU/g 1.59 3.89 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48842 461
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 25.83 ml/min/kg 1.16 3.47 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57787 526
FHH-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 28.21 ml/min 2.28 7.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16677 381
FHH-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 32.81 ml/min 2.91 9.21 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16682 381
FHH-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.79 null 0.05 0.15 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55603 522
FHH-Chr 2BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 10 137.6 g 5.4 17.2 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55397 522
FHH-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 1.89 g/mg 0.16 0.48 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55766 522
FHH-Chr 2BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 187.6 g 5.7 18.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58341 526
FHH-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54884 522
FHH-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.0 0.01 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54900 522
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 58476 526
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.55 null 0.04 0.12 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58725 526
FHH-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 79.67 % 4.62 13.87 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57202 522
FHH-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 67.38 % 4.77 13.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57218 522
FHH-Chr 2BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.35 ml 0.04 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17362 381
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 136.34 mmHg 8.96 25.34 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45721 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 56.31 mmHg 6.03 15.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46409 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49 days-63 days 3 0.24 IU/g 0.08 0.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47284 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 5.44 ml/min/g 0.54 1.32 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46188 461
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 96.04 % 4.33 13.69 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53970 381
FHH-Chr 2BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 125.8 % 7.24 22.89 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54075 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15220 381
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 9 post-ischemic value/pre-ischemic value x 100% 33.83 % 4.05 12.15 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47064 461
FHH-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 237.98 beats/min 6.42 18.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48189 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 78.07 % 8.12 21.49 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48287 461
FHH-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 49.57 % 9.45 23.14 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46306 461
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 119.64 % 4.94 13.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44910 461
FHH-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.36 mg/dl 0.03 0.09 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39563 401
FHH-Chr 2BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 77.0 mg/dl 2.9 8.19 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38420 401
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 950.88 s 32.21 91.11 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49291 461
FHH-Chr 2BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 25.5 mmol/l 2.15 6.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42993 401
FHH-Chr 2BN/Mcwi blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.31 x 1000 cells/ul 0.07 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40297 401
FHH-Chr 2BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 12.88 g/dl 0.46 1.3 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40089 401
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 929.67 s 48.09 117.81 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50106 461
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77 days-91 days 4 3.54 mg/kg 1.04 2.08 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59152 526
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 11.56 ml/min/kg 0.76 2.29 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57590 526
FHH-Chr 2BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.25 mg/dl 0.03 0.08 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42649 401
FHH-Chr 2BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 47.63 ml/min 2.6 8.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14487 381
FHH-Chr 2BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 45.69 ml/min 2.99 9.46 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20748 381
FHH-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount female 80 days-99 days 5 0.24 mg/dl 0.02 0.05 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52250 482
FHH-Chr 2BN/Mcwi plasma creatinine level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data blood creatinine amount male 80 days-99 days 4 0.3 mg/dl 0.06 0.12 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52269 482
FHH-Chr 2BN/Mcwi urine albumin excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine albumin amount male 80 days-99 days 5 117.94 mg/d 38.55 86.21 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52412 482
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 162.69 % 13.91 44.0 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14190 381
FHH-Chr 2BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 148.85 breaths/min 3.99 12.61 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16898 381
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 295.13 U/l 6.81 19.25 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37453 401
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during7-9 min hypercapnia/control during standard conditions 126.84 % 6.0 18.97 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18530 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 180.21 breaths/min 6.05 19.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18257 381
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49 days-63 days 9 114.8 g 6.4 19.3 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49512 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 29.38 mmHg 2.53 7.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49989 461
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 56.6 % 1.01 2.84 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38983 401
FHH-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 16.75 mmol/l 0.65 1.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42049 401
FHH-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 141.75 mmol/l 0.84 2.38 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39380 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 18.36 pg 0.08 0.21 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42537 401
FHH-Chr 2BN/Mcwi serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77 days-91 days 8 24.75 mmol/l 1.81 5.12 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42977 401
FHH-Chr 2BN/Mcwi plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77 days-91 days 8 18.0 mmol/l 2.58 7.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43118 401
FHH-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.35 x 1000 cells/ul 0.15 0.44 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43216 401
FHH-Chr 2BN/Mcwi percent change in respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 137.84 % 7.63 24.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53618 381
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.57 mg/kg 0.74 2.22 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 58898 526
FHH-Chr 2BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.74 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40410 401
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77 days-91 days 8 46.63 U/l 1.38 3.89 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40706 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77 days-91 days 8 52.74 % 1.18 3.33 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59244 526
FHH-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 21.0 mg/dl 1.05 2.98 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40815 401
FHH-Chr 2BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77 days-91 days 8 10.9 mg/dl 1.34 3.78 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37814 401
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 0.18 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59539 526
FHH-Chr 2BN/Mcwi blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.07 x 1000 cells/ul 0.04 0.13 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41407 401
FHH-Chr 2BN/Mcwi blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 16.8 g/dl 0.35 0.99 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 37955 401
FHH-Chr 2BN/Mcwi serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 5.1 mmol/l 0.17 0.46 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38058 401
FHH-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 5.96 x 1000 cells/ul 1.19 3.38 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41490 401
FHH-Chr 2BN/Mcwi blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 5.18 x 1000 cells/ul 0.62 1.75 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41495 401
FHH-Chr 2BN/Mcwi blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77 days-91 days 8 0.05 x 1000 cells/ul 0.01 0.04 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41639 401
FHH-Chr 2BN/Mcwi plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77 days-91 days 8 22.5 mmol/l 0.57 1.6 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38253 401
FHH-Chr 2BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77 days-91 days 8 53.84 fl 0.35 1.0 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38634 401
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 1198.67 s 57.22 140.15 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46535 461
FHH-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49 days-63 days 10 0.79 g 0.05 0.16 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45392 461
FHH-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 20.8 % 3.0 7.36 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48514 461
FHH-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 24.97 ml/min 2.03 6.42 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16134 381
FHH-Chr 2BN/Mcwi minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 33.59 ml/min 3.7 11.7 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16139 381
FHH-Chr 2BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16460 381
FHH-Chr 2BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.36 ml 0.04 0.13 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16465 381
FHH-Chr 2BN/Mcwi concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.02 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54668 522
FHH-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.71 null 0.11 0.32 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 56083 522
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 13.41 ml/min/kg 1.31 3.69 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59997 526
FHH-Chr 2BN/Mcwi heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 7.61 g/kg 0.35 1.04 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45610 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.07 mmHg 0.58 1.65 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47189 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 8 0.54 IU/g 0.2 0.57 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47442 461
FHH-Chr 2BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 145.64 % 10.98 34.72 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54069 381
FHH-Chr 2BN/Mcwi serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77 days-91 days 8 360.63 U/l 8.02 22.67 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36371 401
FHH-Chr 2BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77 days-91 days 8 4.35 x 1000 cells/ul 0.44 1.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36872 401
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 7 155.46 beats/min 14.13 37.38 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45135 461
FHH-Chr 2BN/Mcwi heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 158.11 beats/min 12.95 34.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45140 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 73.34 % 4.6 13.01 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48398 461
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 56.75 % 5.32 14.08 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46058 461
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 31.89 g/dl 0.15 0.41 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39764 401
FHH-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 1.63 g/mg 0.17 0.51 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55782 522
FHH-Chr 2BN/Mcwi body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.39 degrees C 0.15 0.48 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16564 381
FHH-Chr 2BN/Mcwi serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 8 154.75 mg/dl 2.94 8.31 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38522 401
FHH-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.18 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41855 401
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 77.32 mmHg 3.65 10.32 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49875 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 78.91 mmHg 9.3 24.6 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49880 461
FHH-Chr 2BN/Mcwi dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77 days-91 days 9 2.24 mg/kg 0.37 1.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 59168 526
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77 days-91 days 10 0.56 null 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 58720 526
FHH-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 1.57 E-7mole 0.17 0.5 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56514 522
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.17 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59534 526
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.09 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59875 526
FHH-Chr 2BN/Mcwi red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 8.98 x 10E6 cells/ul 0.18 0.51 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39224 401
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.24 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15225 381
FHH-Chr 2BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.38 degrees C 0.18 0.56 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15656 381
FHH-Chr 2BN/Mcwi tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.01 0.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 13910 381
FHH-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 131.78 breaths/min 6.18 19.55 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18402 381
FHH-Chr 2BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.57 degrees C 0.17 0.53 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13551 381
FHH-Chr 2BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 163.82 breaths/min 9.3 29.41 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 16903 381
FHH-Chr 2BN/Mcwi serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77 days-91 days 8 9.21 mg/dl 0.17 0.47 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36611 401
FHH-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.38 degrees C 0.24 0.77 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19061 381
FHH-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 173.3 beats/min 8.93 25.25 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48937 461
FHH-Chr 2BN/Mcwi heart wet weight control condition PhysGen Cardiac data heart mass female 49 days-63 days 8 0.72 g 0.03 0.07 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49047 461
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 36.64 ml/min 3.36 10.64 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20200 381
FHH-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.13 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20301 381
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 4.94 mmHg 0.27 0.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49164 461
FHH-Chr 2BN/Mcwi serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77 days-91 days 8 142.38 mmol/l 0.82 2.33 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36493 401
FHH-Chr 2BN/Mcwi time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 993.63 s 19.12 54.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50111 461
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 10 1256.8 s 42.07 133.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50214 461
FHH-Chr 2BN/Mcwi percent change in ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 %change=VE during 2-3 min hypercapnia/control during standard conditions 199.43 % 15.32 48.44 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 19198 381
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77 days-91 days 8 102.88 U/l 7.3 20.65 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42420 401
FHH-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77 days-91 days 8 3.63 g/dl 0.06 0.17 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42225 401
FHH-Chr 2BN/Mcwi blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77 days-91 days 8 1.22 x 1000 cells/ul 0.14 0.39 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38899 401
FHH-Chr 2BN/Mcwi serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77 days-91 days 8 16.25 mmol/l 0.56 1.58 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42054 401
FHH-Chr 2BN/Mcwi serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77 days-91 days 8 79.25 U/l 3.31 9.36 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42757 401
FHH-Chr 2BN/Mcwi serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77 days-91 days 8 140.63 mmol/l 0.92 2.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39375 401
FHH-Chr 2BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77 days-91 days 8 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42870 401
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 147.99 % 11.65 36.84 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54310 381
FHH-Chr 2BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 120.91 % 6.36 20.1 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54415 381
FHH-Chr 2BN/Mcwi blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77 days-91 days 8 1.01 x 1000 cells/ul 0.31 0.88 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 43211 401
FHH-Chr 2BN/Mcwi serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.75 g/dl 0.09 0.26 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40394 401
FHH-Chr 2BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77 days-91 days 7 4.36 mmol/l 0.24 0.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43314 401
FHH-Chr 2BN/Mcwi plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77 days-91 days 8 0.33 mg/dl 0.03 0.07 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 39568 401
FHH-Chr 2BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77 days-91 days 8 103.5 mmol/l 0.53 1.51 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40009 401
FHH-Chr 2BN/Mcwi blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 13.98 g/dl 0.42 1.18 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40105 401
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77 days-91 days 9 0.03 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59345 526
FHH-Chr 2BN/Mcwi serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 9.45 mg/dl 0.27 0.77 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37586 401
FHH-Chr 2BN/Mcwi serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77 days-91 days 8 42.88 U/l 3.06 8.66 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37694 401
FHH-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 7.41 x 1000 cells/ul 1.54 4.35 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40913 401
FHH-Chr 2BN/Mcwi fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77 days-91 days 8 0.03 mmHg-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59361 526
FHH-Chr 2BN/Mcwi serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77 days-91 days 8 10.29 mg/dl 1.35 3.82 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37830 401
FHH-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 39.51 % 1.32 3.73 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41289 401
FHH-Chr 2BN/Mcwi lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77 days-91 days 10 1.56 g/kg 0.04 0.13 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 59649 526
FHH-Chr 2BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 20.25 mg/dl 1.63 4.62 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41755 401
FHH-Chr 2BN/Mcwi heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49 days-63 days 9 0.87 g 0.07 0.2 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 45397 461
FHH-Chr 2BN/Mcwi mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77 days-91 days 8 52.46 fl 0.31 0.87 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38650 401
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 13.68 ml/min/kg 0.91 2.74 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57585 526
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 43.98 ml/min/kg 2.01 5.31 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57991 526
FHH-Chr 2BN/Mcwi body weight control condition (for 14 days) PhysGen Lung data body mass female 77 days-91 days 10 139.0 g 2.2 7.1 whole body digital scale 0 Moms and pups used in studies were fed Teklad 58325 526
FHH-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait male 82 days-99 days 10 37.26 degrees C 0.2 0.65 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 16804 381
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 23.25 ml/min/kg 1.91 5.39 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58626 526
FHH-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 69.67 % 3.25 9.75 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54774 522
FHH-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70 days-84 days 9 170.2 g 5.9 17.8 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55163 522
FHH-Chr 2BN/Mcwi body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 9 219.8 g 6.0 18.0 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55177 522
FHH-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 -6.75 null 0.07 0.22 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56893 522
FHH-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 9 -6.82 null 0.04 0.13 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 56909 522
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 8.76 ml/min/g 0.66 1.74 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46862 461
FHH-Chr 2BN/Mcwi body weight control condition PhysGen Cardiac data body mass male 49 days-63 days 10 139.6 g 5.5 17.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 47807 461
FHH-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 240.63 beats/min 14.08 34.48 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48184 461
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 55.6 % 5.26 12.88 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46053 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 98.94 mmHg 5.65 15.97 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44807 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 5.52 mmHg 0.46 1.39 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47184 461
FHH-Chr 2BN/Mcwi percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 25.13 % 1.46 4.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47069 461
FHH-Chr 2BN/Mcwi percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 72.19 % 7.89 19.31 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48393 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 7 22.6 mmHg 5.69 15.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45262 461
FHH-Chr 2BN/Mcwi body weight control condition PhysGen Respiratory data body mass male 82 days-99 days 10 192.8 g 10.2 32.2 whole body digital scale 0 Moms and pups used in studies were fed Dyets 17809 381
FHH-Chr 2BN/Mcwi respiration rate control condition PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 116.1 breaths/min 3.87 12.23 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18397 381
FHH-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount female 80 days-99 days 6 12.48 mEq/d 2.12 5.19 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52787 482
FHH-Chr 2BN/Mcwi urine sodium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine sodium amount male 80 days-99 days 5 17.74 mEq/d 4.06 9.07 flame atomic emission spectrometry 0 Moms were fed Teklad, pups used in studies were fed Dyets 52806 482
FHH-Chr 2BN/Mcwi body temperature control condition PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.15 degrees C 0.19 0.59 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 19056 381
FHH-Chr 2BN/Mcwi minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 43.49 ml/min 2.84 8.99 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18654 381
FHH-Chr 2BN/Mcwi blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77 days-91 days 8 3.31 x 1000 cells/ul 0.41 1.15 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 36856 401
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 53.91 mmHg 4.94 13.96 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46404 461
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 9 119.64 mmHg 8.17 24.5 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45716 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 52.66 mmHg 3.81 10.79 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47693 461
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 7 4.88 ml/min/g 0.43 1.14 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46193 461
FHH-Chr 2BN/Mcwi logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70 days-84 days 8 -6.89 null 0.07 0.19 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55619 522
FHH-Chr 2BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77 days-91 days 8 3.89 x 1000 cells/ul 0.45 1.28 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39872 401
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 134.9 % 8.26 26.11 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53737 381
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77 days-91 days 8 17.29 pg 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40201 401
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49 days-63 days 8 10.59 % 3.35 9.48 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49685 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 10 25.6 mmHg 1.97 6.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49984 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 112.43 mmHg 9.17 25.93 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48611 461
FHH-Chr 2BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77 days-91 days 8 1.5 g/dl 0.06 0.18 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41030 401
FHH-Chr 2BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77 days-91 days 7 131.57 mg/dl 4.85 12.83 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41181 401
FHH-Chr 2BN/Mcwi hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 42.44 % 1.18 3.34 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41305 401
FHH-Chr 2BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 143.99 breaths/min 5.38 17.01 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17098 381
FHH-Chr 2BN/Mcwi respiration rate air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 154.33 breaths/min 11.4 36.04 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17103 381
FHH-Chr 2BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 54.37 ml/min 6.93 21.93 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 20753 381
FHH-Chr 2BN/Mcwi serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77 days-91 days 8 5.28 g/dl 0.08 0.23 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 36954 401
FHH-Chr 2BN/Mcwi serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77 days-91 days 8 5.03 g/dl 0.14 0.4 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37185 401
FHH-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.23 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15384 381
FHH-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 0.29 ml 0.02 0.07 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 15389 381
FHH-Chr 2BN/Mcwi absolute change in body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82 days-99 days 10 0.19 degrees C 0.1 0.31 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 15661 381
FHH-Chr 2BN/Mcwi heart rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data heart pumping trait female 80 days-99 days 5 419.9 beats/min 8.37 18.73 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52491 482
FHH-Chr 2BN/Mcwi mean arterial blood pressure controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data arterial blood pressure trait male 80 days-99 days 5 182.24 mmHg 14.91 33.34 vascular fluid filled catheter 0 Moms were fed Teklad, pups used in studies were fed Dyets 52557 482
FHH-Chr 2BN/Mcwi plasma renin activity level controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data renin activity male 80 days-99 days 4 1.73 ng/ml/h 0.23 0.46 radioimmunoassay 0 Moms were fed Teklad, pups used in studies were fed Dyets 52904 482
FHH-Chr 2BN/Mcwi urine potassium excretion rate controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) PhysGen Renal B data urine potassium amount female 80 days-99 days 6 0.87 mEq/d 0.13 0.32 flame atomic emission spectrometry 0 urine potassium analysis Moms were fed Teklad, pups used in studies were fed Dyets 52299 482
FHH-Chr 2BN/Mcwi body temperature air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 37.53 degrees C 0.12 0.38 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 13546 381
FHH-Chr 2BN/Mcwi tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.24 ml 0.02 0.05 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17969 381
FHH-Chr 2BN/Mcwi absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82 days-99 days 10 0.29 degrees C 0.12 0.37 digital rectal thermometry 0 Moms and pups used in studies were fed Teklad 20296 381
FHH-Chr 2BN/Mcwi respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82 days-99 days 10 171.76 breaths/min 14.25 45.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 18252 381
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1161.88 s 40.68 115.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 50219 461
FHH-Chr 2BN/Mcwi serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77 days-91 days 8 3.36 g/dl 0.09 0.24 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42220 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 52.74 % 1.18 3.33 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 38978 401
FHH-Chr 2BN/Mcwi blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77 days-91 days 8 0.29 x 1000 cells/ul 0.07 0.19 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39666 401
FHH-Chr 2BN/Mcwi percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82 days-99 days 10 140.15 % 9.57 30.26 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54316 381
FHH-Chr 2BN/Mcwi percent change in tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 144.65 % 11.0 34.78 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 54409 381
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77 days-91 days 10 157.3 g 3.9 12.4 whole body digital scale 0 Moms and pups used in studies were fed Teklad 59054 526
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 17.55 pg 0.08 0.23 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40185 401
FHH-Chr 2BN/Mcwi serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77 days-91 days 7 4.5 mmol/l 0.11 0.29 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 43330 401
FHH-Chr 2BN/Mcwi serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77 days-91 days 8 104.75 mmol/l 0.45 1.28 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 39993 401
FHH-Chr 2BN/Mcwi serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77 days-91 days 8 27.88 mg/dl 1.33 3.76 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 40820 401
FHH-Chr 2BN/Mcwi total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 6.86 x 1000 cells/ul 0.76 2.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 40918 401
FHH-Chr 2BN/Mcwi hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77 days-91 days 8 56.6 % 1.01 2.84 microhematocrit tube assay with visual assessment 0 Moms and pups used in studies were fed Teklad 59249 526
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.38 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59760 526
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.38 null 0.01 0.03 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 59776 526
FHH-Chr 2BN/Mcwi serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.27 g/dl 0.07 0.19 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 41014 401
FHH-Chr 2BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77 days-91 days 8 7.34 x 10E6 cells/ul 0.27 0.76 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41956 401
FHH-Chr 2BN/Mcwi red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77 days-91 days 8 8.09 x 10E6 cells/ul 0.25 0.7 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 41972 401
FHH-Chr 2BN/Mcwi left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 83.29 mmHg 4.9 13.85 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45496 461
FHH-Chr 2BN/Mcwi logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70 days-84 days 9 -7.7 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer 0 EC50 value is moles/liter Moms and pups used in studies were fed Teklad 55253 522
FHH-Chr 2BN/Mcwi methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 9 19.42 ml/min/kg 1.04 3.13 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 57792 526
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 7 post-ischemic value/pre-ischemic value x 100% 59.59 % 6.15 16.26 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48748 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 7 6.34 IU/g 1.97 5.22 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 48853 461
FHH-Chr 2BN/Mcwi maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70 days-84 days 9 0.73 g/mg 0.09 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 57328 522
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 77.55 ml/min/kg 8.17 24.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58214 526
FHH-Chr 2BN/Mcwi concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 1.72 E-7mole 0.19 0.58 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 55872 522
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77 days-91 days 9 0.48 null 0.04 0.11 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58100 526
FHH-Chr 2BN/Mcwi methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 7 0.43 null 0.03 0.09 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58105 526
FHH-Chr 2BN/Mcwi acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70 days-84 days 9 69.22 % 5.23 15.68 wire myography using a Digi-Med tissue force analysis system with force transducer 0 Moms and pups used in studies were fed Teklad 54758 522
FHH-Chr 2BN/Mcwi tidal volume air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82 days-99 days 10 0.32 ml 0.02 0.06 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 17357 381
FHH-Chr 2BN/Mcwi arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49 days-63 days 8 10.4 ml/min/g 0.69 1.94 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 46645 461
FHH-Chr 2BN/Mcwi percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 post-ischemic value/pre-ischemic value x 100% 59.92 % 2.85 8.05 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46311 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 41.56 mmHg 7.41 18.16 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47898 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 46.28 mmHg 3.36 9.51 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47903 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49 days-63 days 6 33.33 mmHg 4.6 11.27 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48020 461
FHH-Chr 2BN/Mcwi heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49 days-63 days 8 33.25 mmHg 2.82 7.98 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48025 461
FHH-Chr 2BN/Mcwi percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 post-ischemic value/pre-ischemic value x 100% 89.5 % 12.36 30.28 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 44905 461
FHH-Chr 2BN/Mcwi heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49 days-63 days 3 0.08 IU/g 0.02 0.04 isolated perfused heart effluent collection 0 Moms and pups used in studies were fed Teklad 47300 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 5.61 mmHg 0.23 0.66 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 49169 461
FHH-Chr 2BN/Mcwi percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 96.69 % 7.51 23.73 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 53976 381
FHH-Chr 2BN/Mcwi heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49 days-63 days 6 170.01 beats/min 14.43 35.35 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 48932 461
FHH-Chr 2BN/Mcwi minute ventilation air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82 days-99 days 10 60.56 ml/min 8.11 25.63 stop flow air displacement plethysmography 0 Moms and pups used in studies were fed Teklad 14492 381
FHH-Chr 2BN/Mcwi serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77 days-91 days 8 59.63 mg/dl 2.93 8.3 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 37084 401
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 8 23.41 mmHg 3.91 11.07 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 45257 461
FHH-Chr 2BN/Mcwi left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49 days-63 days 6 39.97 mmHg 6.63 16.24 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 47688 461
FHH-Chr 2BN/Mcwi left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49 days-63 days 8 77.68 mmHg 5.03 14.23 balloon tipped catheter with pressure transducer in isolated perfused heart 0 46742 461
FHH-Chr 2BN/Mcwi heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49 days-63 days 10 5.21 g/kg 0.19 0.6 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 46985 461
FHH-Chr 2BN/Mcwi FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 61.22 ml/min/kg 4.78 13.52 isolated perfused lung vascular effluent collection 0 Moms and pups used in studies were fed Teklad 58230 526
FHH-Chr 2BN/Mcwi serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.09 mg/dl 0.01 0.02 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 42886 401
FHH-Chr 2BN/Mcwi total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77 days-91 days 8 5.95 x 1000 cells/ul 0.55 1.56 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 39888 401
FHH-Chr 2BN/Mcwi body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49 days-63 days 10 103.6 g 4.3 13.5 whole body digital scale 0 Moms and pups used in studies were fed Teklad 49496 461
FHH-Chr 2BN/Mcwi serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77 days-91 days 8 91.0 mg/dl 3.59 10.14 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 38436 401
FHH-Chr 2BN/Mcwi serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77 days-91 days 8 17.63 mg/dl 1.08 3.07 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41739 401
FHH-Chr 2BN/Mcwi time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49 days-63 days 8 1188.0 s 23.23 65.69 balloon tipped catheter with pressure transducer in isolated perfused heart 0 Moms and pups used in studies were fed Teklad 46540 461
FHH-Chr 2BN/Mcwi heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49 days-63 days 7 9.12 % 1.74 4.61 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 49690 461
FHH-Chr 2BN/Mcwi serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77 days-91 days 8 0.13 mg/dl 0.02 0.05 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41860 401
FHH-Chr 2BN/Mcwi serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77 days-91 days 8 1.5 g/dl 0.07 0.2 standard blood chemistry panel 0 replaced obsolete serum globulin level term, 1/19/2016 Moms and pups used in studies were fed Teklad 40537 401
FHH-Chr 2BN/Mcwi calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77 days-91 days 8 0.12 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung 0 Moms and pups used in studies were fed Teklad 59891 526
FHH-Chr 2BN/Mcwi serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77 days-91 days 7 134.29 mg/dl 2.5 6.63 standard blood chemistry panel 0 Moms and pups used in studies were fed Teklad 41197 401
FHH-Chr 2BN/Mcwi mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77 days-91 days 8 18.73 pg 0.06 0.16 automated blood cell counting method 0 Moms and pups used in studies were fed Teklad 42532 401
FHH-Chr 2BN/Mcwi plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77 days-91 days 8 0.31 mg/dl 0.04 0.1 automated plasma creatinine analysis 0 Moms and pups used in studies were fed Teklad 42633 401
FHH-Chr 2BN/Mcwi body weight control condition (for 21 days) PhysGen Vascular data body mass male 70 days-84 days 10 165.0 g 6.3 19.9 whole body digital scale 0 Moms and pups used in studies were fed Teklad 55411 522
FHH-Chr 2BN/Mcwi heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77 days-91 days 10 0.28 null 0.01 0.05 digital scale post excision weight measurement 0 Moms and pups used in studies were fed Teklad 57904 526