FHH-Chr 12BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
121.4 |
% |
7.59 |
25.19 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13671 |
381 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
female |
82 days-99 days |
12 |
|
30.63 |
mmHg |
0.54 |
1.88 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17214 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
105.47 |
% |
3.84 |
16.75 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53868 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
97.92 |
% |
3.21 |
13.97 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53969 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
103.43 |
% |
8.23 |
27.29 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53975 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
11 |
|
415.2 |
beats/min |
13.22 |
43.84 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20905 |
381 |
FHH-Chr 12BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
12 |
|
5.93 |
g/dl |
0.04 |
0.13 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36947 |
401 |
FHH-Chr 12BN/Mcwi |
serum total protein level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
female |
77 days-91 days |
11 |
|
5.76 |
g/dl |
0.1 |
0.34 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37181 |
401 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood oxygen |
control condition |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
103.06 |
mmHg |
3.37 |
11.17 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18851 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
15 |
|
421.37 |
beats/min |
8.75 |
33.89 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15902 |
381 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
61.34 |
ml/min |
5.17 |
16.33 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14491 |
381 |
FHH-Chr 12BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
female |
80 days-99 days |
10 |
|
157.28 |
mg/d |
60.1 |
190.06 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52094 |
482 |
FHH-Chr 12BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
11 |
|
129.58 |
breaths/min |
4.82 |
15.97 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14785 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
%change=VE during 2-3 min hypoxia/control during standard conditions |
134.35 |
% |
5.92 |
25.78 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13665 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
0.25 |
ml |
0.02 |
0.05 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17973 |
381 |
FHH-Chr 12BN/Mcwi |
serum alkaline phosphatase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
12 |
|
365.58 |
U/l |
11.9 |
41.23 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37449 |
401 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
17 |
|
411.57 |
beats/min |
13.0 |
53.6 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17475 |
381 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
28.0 |
ml/min |
0.84 |
3.65 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18647 |
381 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
33.51 |
ml/min |
1.39 |
4.6 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18653 |
381 |
FHH-Chr 12BN/Mcwi |
blood lymphocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
12 |
|
3.47 |
x 1000 cells/ul |
0.35 |
1.22 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36868 |
401 |
FHH-Chr 12BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
10 |
|
36.69 |
degrees C |
0.26 |
0.82 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19060 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
22 |
|
214.21 |
beats/min |
13.53 |
63.48 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48930 |
461 |
FHH-Chr 12BN/Mcwi |
heart wet weight |
control condition |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
22 |
|
0.9 |
g |
0.04 |
0.18 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49051 |
461 |
FHH-Chr 12BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
11 |
|
129.06 |
breaths/min |
5.06 |
16.79 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18256 |
381 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
19 |
|
5.55 |
mmHg |
0.22 |
0.97 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49162 |
461 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
12 |
|
55.69 |
mmHg |
1.25 |
4.32 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20447 |
381 |
FHH-Chr 12BN/Mcwi |
time to onset of heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
22 |
|
966.95 |
s |
32.86 |
154.13 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50104 |
461 |
FHH-Chr 12BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
16 |
|
1196.63 |
s |
65.49 |
261.97 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50212 |
461 |
FHH-Chr 12BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
15 |
|
891.13 |
s |
79.07 |
306.24 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49284 |
461 |
FHH-Chr 12BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
11 |
|
55.58 |
fl |
0.18 |
0.61 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38736 |
401 |
FHH-Chr 12BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
12 |
|
82.08 |
U/l |
2.68 |
9.28 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42755 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
12 |
|
18.31 |
pg |
0.06 |
0.21 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42530 |
401 |
FHH-Chr 12BN/Mcwi |
total white blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
12 |
|
4.74 |
x 1000 cells/ul |
0.44 |
1.52 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39884 |
401 |
FHH-Chr 12BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
12 |
|
0.11 |
x 1000 cells/ul |
0.02 |
0.06 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39659 |
401 |
FHH-Chr 12BN/Mcwi |
blood monocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
11 |
|
0.22 |
x 1000 cells/ul |
0.04 |
0.15 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39665 |
401 |
FHH-Chr 12BN/Mcwi |
serum bicarbonate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
12 |
|
19.83 |
mmol/l |
1.4 |
4.84 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42989 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
10 |
|
143.04 |
% |
5.46 |
17.27 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53623 |
381 |
FHH-Chr 12BN/Mcwi |
serum chloride level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
11 |
|
106.91 |
mmol/l |
0.67 |
2.21 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39989 |
401 |
FHH-Chr 12BN/Mcwi |
serum globulin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
11 |
|
2.05 |
g/dl |
0.05 |
0.16 |
standard blood chemistry panel |
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
41010 |
401 |
FHH-Chr 12BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
12 |
|
4.89 |
x 1000 cells/ul |
0.44 |
1.53 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40911 |
401 |
FHH-Chr 12BN/Mcwi |
serum chloride level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
12 |
|
104.67 |
mmol/l |
0.7 |
2.42 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40005 |
401 |
FHH-Chr 12BN/Mcwi |
serum glucose level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
11 |
|
155.27 |
mg/dl |
2.5 |
8.28 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41193 |
401 |
FHH-Chr 12BN/Mcwi |
serum alanine aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
12 |
|
70.17 |
U/l |
3.35 |
11.61 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37706 |
401 |
FHH-Chr 12BN/Mcwi |
serum phosphate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
11 |
|
7.67 |
mg/dl |
0.35 |
1.17 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37810 |
401 |
FHH-Chr 12BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
12 |
|
4.08 |
x 1000 cells/ul |
0.43 |
1.5 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41488 |
401 |
FHH-Chr 12BN/Mcwi |
serum urea nitrogen level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
11 |
|
14.0 |
mg/dl |
1.11 |
3.69 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41735 |
401 |
FHH-Chr 12BN/Mcwi |
time to peak heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
21 |
|
1211.05 |
s |
31.11 |
142.56 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46539 |
461 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
12 |
|
16.94 |
ml/min/kg |
0.59 |
2.05 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57583 |
526 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
11 |
|
13.9 |
ml/min/kg |
0.58 |
1.91 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57589 |
526 |
FHH-Chr 12BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
12 |
|
1.31 |
g/mg |
0.14 |
0.49 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57308 |
522 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
28.38 |
ml/min |
1.68 |
5.57 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16681 |
381 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
-8.41 |
null |
0.1 |
0.26 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56026 |
522 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
12 |
|
-8.28 |
null |
0.21 |
0.74 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56079 |
522 |
FHH-Chr 12BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
11 |
|
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54648 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
6.0 |
% |
3.06 |
5.29 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55130 |
522 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
12 |
|
-6.85 |
null |
0.07 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56889 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
31.86 |
% |
2.67 |
7.06 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57144 |
522 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
22 |
|
163.0 |
g |
6.9 |
32.2 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47803 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
5 |
|
103.38 |
mmHg |
3.21 |
7.19 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
|
46741 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
22 |
|
48.37 |
mmHg |
3.76 |
17.64 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47896 |
461 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
10 |
|
4.36 |
ml/min/g |
0.47 |
1.49 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44709 |
461 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
22 |
|
254.62 |
beats/min |
7.85 |
36.81 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48182 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
7 |
post-ischemic value/pre-ischemic value x 100% |
88.59 |
% |
6.47 |
17.12 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44903 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
5 |
post-ischemic value/pre-ischemic value x 100% |
75.4 |
% |
19.31 |
43.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44909 |
461 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
32.71 |
ml/min |
2.41 |
7.99 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20199 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
12 |
|
-6.89 |
mmHg |
0.78 |
2.71 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19607 |
381 |
FHH-Chr 12BN/Mcwi |
serum total protein level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
12 |
|
5.6 |
g/dl |
0.13 |
0.44 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37197 |
401 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
female |
80 days-99 days |
11 |
|
163.84 |
mmHg |
7.46 |
24.74 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52531 |
482 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
14 |
|
52.44 |
mmHg |
3.49 |
13.04 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46402 |
461 |
FHH-Chr 12BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
12 |
|
0.55 |
null |
0.02 |
0.08 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58098 |
526 |
FHH-Chr 12BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
9 |
|
0.5 |
null |
0.04 |
0.11 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58104 |
526 |
FHH-Chr 12BN/Mcwi |
FAPGG metabolism-surface area product |
FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
11 |
|
67.87 |
ml/min/kg |
3.78 |
12.53 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58210 |
526 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
149.26 |
% |
4.9 |
20.18 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54408 |
381 |
FHH-Chr 12BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
60.88 |
% |
4.67 |
18.66 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54770 |
522 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
17 |
|
173.59 |
% |
7.37 |
30.4 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53617 |
381 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
18 |
|
138.3 |
g |
2.1 |
8.7 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49492 |
461 |
FHH-Chr 12BN/Mcwi |
time to onset of heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
21 |
|
995.9 |
s |
35.99 |
164.94 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50110 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
%change=VE during 2-3 min hypercapnia/control during standard conditions |
222.25 |
% |
17.11 |
54.1 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19202 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
16 |
|
262.5 |
beats/min |
10.58 |
42.31 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47567 |
461 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
20.3 |
% |
4.35 |
13.77 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55053 |
522 |
FHH-Chr 12BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
female |
77 days-91 days |
12 |
|
8.28 |
mg/dl |
0.22 |
0.77 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37579 |
401 |
FHH-Chr 12BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
female |
77 days-91 days |
12 |
|
21.25 |
mg/dl |
0.66 |
2.3 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40813 |
401 |
FHH-Chr 12BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
male |
77 days-91 days |
11 |
|
53.82 |
U/l |
2.48 |
8.22 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40705 |
401 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
12 |
|
24.86 |
ml/min/kg |
1.05 |
3.64 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57785 |
526 |
FHH-Chr 12BN/Mcwi |
blood eosinophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
12 |
|
0.02 |
x 1000 cells/ul |
0.01 |
0.03 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41403 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
10 |
|
138.51 |
% |
4.58 |
14.49 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54208 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
17 |
|
140.16 |
breaths/min |
2.16 |
8.91 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17096 |
381 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
51.95 |
ml/min |
2.61 |
8.25 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20752 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
12 |
|
0.06 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19757 |
381 |
FHH-Chr 12BN/Mcwi |
serum total protein level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood total protein amount |
male |
77 days-91 days |
11 |
|
5.87 |
g/dl |
0.06 |
0.2 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36953 |
401 |
FHH-Chr 12BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
11 |
|
81.45 |
mg/dl |
2.51 |
8.31 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37088 |
401 |
FHH-Chr 12BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
11 |
|
113.93 |
breaths/min |
4.62 |
15.33 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18401 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
10 |
|
400.83 |
beats/min |
14.89 |
47.09 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15912 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
0.23 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15218 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
0.25 |
ml |
0.02 |
0.06 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15224 |
381 |
FHH-Chr 12BN/Mcwi |
urine total protein excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
total urine protein amount |
male |
80 days-99 days |
11 |
|
368.02 |
mg/d |
45.8 |
151.92 |
automated urine total protein analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52113 |
482 |
FHH-Chr 12BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
male |
80 days-99 days |
11 |
|
14.16 |
mEq/d |
1.75 |
5.8 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52799 |
482 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
male |
80 days-99 days |
12 |
|
431.99 |
beats/min |
6.5 |
22.51 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52503 |
482 |
FHH-Chr 12BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
female |
80 days-99 days |
7 |
|
7.44 |
ng/ml/h |
1.44 |
3.8 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52878 |
482 |
FHH-Chr 12BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
female |
80 days-99 days |
10 |
|
0.9 |
mEq/d |
0.07 |
0.21 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52292 |
482 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
15 |
|
113.14 |
mmHg |
3.66 |
14.18 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13459 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
17 |
|
157.17 |
breaths/min |
5.8 |
23.9 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16896 |
381 |
FHH-Chr 12BN/Mcwi |
blood lymphocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
female |
77 days-91 days |
11 |
|
2.89 |
x 1000 cells/ul |
0.22 |
0.71 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36852 |
401 |
FHH-Chr 12BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
11 |
|
9.71 |
mg/dl |
0.1 |
0.34 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36615 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
120.06 |
% |
12.4 |
41.13 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18534 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
12 |
|
-46.38 |
mmHg |
1.86 |
6.45 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19436 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
-46.57 |
mmHg |
2.47 |
8.2 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19447 |
381 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
21 |
|
5.73 |
mmHg |
0.16 |
0.73 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49168 |
461 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
26.0 |
ml/min |
0.89 |
3.89 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20193 |
381 |
FHH-Chr 12BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
11 |
|
8.86 |
% |
3.33 |
11.03 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49689 |
461 |
FHH-Chr 12BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
12 |
|
3.91 |
g/dl |
0.03 |
0.11 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42218 |
401 |
FHH-Chr 12BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
12 |
|
15.17 |
mmol/l |
0.89 |
3.1 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42047 |
401 |
FHH-Chr 12BN/Mcwi |
serum bicarbonate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
male |
77 days-91 days |
11 |
|
13.64 |
mmol/l |
0.51 |
1.69 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42053 |
401 |
FHH-Chr 12BN/Mcwi |
serum total bilirubin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
11 |
|
0.11 |
mg/dl |
0.01 |
0.03 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42866 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
11 |
|
114.12 |
% |
3.95 |
13.11 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54315 |
381 |
FHH-Chr 12BN/Mcwi |
plasma anion gap |
control condition (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
11 |
|
22.73 |
mmol/l |
0.63 |
2.1 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43114 |
401 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
11 |
|
0.28 |
mg/dl |
0.01 |
0.04 |
automated plasma creatinine analysis |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39567 |
401 |
FHH-Chr 12BN/Mcwi |
blood monocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
male |
77 days-91 days |
12 |
|
0.29 |
x 1000 cells/ul |
0.05 |
0.19 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40293 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
11 |
|
17.44 |
pg |
0.16 |
0.55 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40181 |
401 |
FHH-Chr 12BN/Mcwi |
serum potassium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
11 |
|
4.18 |
mmol/l |
0.13 |
0.43 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43310 |
401 |
FHH-Chr 12BN/Mcwi |
blood hemoglobin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
11 |
|
13.67 |
g/dl |
0.29 |
0.95 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40085 |
401 |
FHH-Chr 12BN/Mcwi |
blood hemoglobin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
12 |
|
14.02 |
g/dl |
0.34 |
1.18 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40101 |
401 |
FHH-Chr 12BN/Mcwi |
serum alanine aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
11 |
|
51.36 |
U/l |
2.39 |
7.92 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37690 |
401 |
FHH-Chr 12BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
0.34 |
null |
0.01 |
0.04 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59756 |
526 |
FHH-Chr 12BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
12 |
|
1.77 |
g/kg |
0.03 |
0.1 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59642 |
526 |
FHH-Chr 12BN/Mcwi |
lung dry weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
12 |
|
1.53 |
g/kg |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59648 |
526 |
FHH-Chr 12BN/Mcwi |
serum glucose level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
11 |
|
164.09 |
mg/dl |
9.56 |
31.7 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41177 |
401 |
FHH-Chr 12BN/Mcwi |
serum globulin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
12 |
|
2.01 |
g/dl |
0.05 |
0.18 |
standard blood chemistry panel |
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
41026 |
401 |
FHH-Chr 12BN/Mcwi |
serum phosphate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
11 |
|
8.04 |
mg/dl |
0.22 |
0.71 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37826 |
401 |
FHH-Chr 12BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
female |
77 days-91 days |
12 |
|
159.75 |
mg/dl |
4.42 |
15.32 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38515 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
8 |
post-ischemic value/pre-ischemic value x 100% |
32.38 |
% |
5.22 |
14.77 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48518 |
461 |
FHH-Chr 12BN/Mcwi |
mean corpuscular volume |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
11 |
|
54.08 |
fl |
0.2 |
0.67 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38630 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular volume |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
male |
77 days-91 days |
12 |
|
52.35 |
fl |
0.17 |
0.58 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38646 |
401 |
FHH-Chr 12BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
11 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41859 |
401 |
FHH-Chr 12BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
11 |
|
42.43 |
% |
0.82 |
2.71 |
microhematocrit tube assay with visual assessment |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57470 |
526 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
21 |
|
179.4 |
g |
2.8 |
12.9 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55393 |
522 |
FHH-Chr 12BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
12 |
|
45.28 |
ml/min/kg |
1.36 |
4.72 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57984 |
526 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
11 |
|
261.0 |
g |
9.2 |
30.5 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55407 |
522 |
FHH-Chr 12BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
0.37 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16458 |
381 |
FHH-Chr 12BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
0.04 |
10E-7mol/l |
0.01 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55732 |
522 |
FHH-Chr 12BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
12 |
|
1.5 |
g/mg |
0.12 |
0.42 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55762 |
522 |
FHH-Chr 12BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
0.75 |
E-7mole |
0.08 |
0.27 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55884 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
10.29 |
% |
1.87 |
4.96 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55081 |
522 |
FHH-Chr 12BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
0.36 |
ml |
0.01 |
0.06 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17355 |
381 |
FHH-Chr 12BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
71.18 |
% |
5.54 |
18.37 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57198 |
522 |
FHH-Chr 12BN/Mcwi |
heart contraction pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
22 |
|
42.55 |
mmHg |
2.45 |
11.51 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48018 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
22 |
post-ischemic value/pre-ischemic value x 100% |
65.22 |
% |
4.3 |
20.15 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46051 |
461 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
19 |
|
6.32 |
ml/min/g |
0.69 |
3.0 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46192 |
461 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
21 |
|
245.76 |
beats/min |
6.15 |
28.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48188 |
461 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
21 |
|
0.39 |
IU/g |
0.04 |
0.21 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47296 |
461 |
FHH-Chr 12BN/Mcwi |
urine sodium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine sodium amount |
female |
80 days-99 days |
10 |
|
12.16 |
mEq/d |
2.29 |
7.24 |
flame atomic emission spectrometry |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52780 |
482 |
FHH-Chr 12BN/Mcwi |
absolute change in partial pressure of blood carbon dioxide |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
11 |
|
-4.05 |
mmHg |
0.64 |
2.12 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19618 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
0.24 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15382 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
15 |
|
369.98 |
beats/min |
6.96 |
26.95 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14672 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
10 |
|
148.15 |
breaths/min |
4.62 |
14.6 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17102 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
10 |
|
153.76 |
breaths/min |
7.87 |
24.89 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16902 |
381 |
FHH-Chr 12BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
17 |
|
37.22 |
degrees C |
0.12 |
0.51 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19054 |
381 |
FHH-Chr 12BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
male |
80 days-99 days |
11 |
|
111.94 |
mg/d |
15.39 |
51.03 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52405 |
482 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
arterial blood pressure trait |
male |
80 days-99 days |
12 |
|
189.93 |
mmHg |
4.66 |
16.14 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52550 |
482 |
FHH-Chr 12BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
16 |
post-ischemic value/pre-ischemic value x 100% |
43.75 |
% |
6.29 |
25.15 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47062 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
5.91 |
mmHg |
0.17 |
0.54 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47188 |
461 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
13 |
|
207.48 |
beats/min |
12.18 |
43.92 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45133 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
59.57 |
mmHg |
5.75 |
18.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46408 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
6 |
|
110.46 |
mmHg |
7.18 |
17.6 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
|
46735 |
461 |
FHH-Chr 12BN/Mcwi |
heart weight to body weight ratio |
control condition |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
22 |
|
5.6 |
g/kg |
0.27 |
1.26 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46981 |
461 |
FHH-Chr 12BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
female |
77 days-91 days |
12 |
|
21.92 |
mmol/l |
0.87 |
3.0 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38246 |
401 |
FHH-Chr 12BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
12 |
|
0.67 |
x 1000 cells/ul |
0.06 |
0.21 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43209 |
401 |
FHH-Chr 12BN/Mcwi |
blood neutrophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
11 |
|
0.91 |
x 1000 cells/ul |
0.11 |
0.36 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43215 |
401 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
-8.44 |
null |
0.1 |
0.17 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54606 |
522 |
FHH-Chr 12BN/Mcwi |
mean corpuscular volume |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte size trait |
female |
77 days-91 days |
12 |
|
56.97 |
fl |
0.18 |
0.62 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38730 |
401 |
FHH-Chr 12BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
12 |
|
43.25 |
mmHg |
3.84 |
13.32 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49988 |
461 |
FHH-Chr 12BN/Mcwi |
serum alanine aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alanine transaminase amount |
female |
77 days-91 days |
12 |
|
41.75 |
U/l |
2.01 |
6.97 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40699 |
401 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
12 |
|
240.81 |
beats/min |
10.48 |
36.32 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47573 |
461 |
FHH-Chr 12BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
17 |
|
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54896 |
522 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
5 |
post-ischemic value/pre-ischemic value x 100% |
43.85 |
% |
11.32 |
25.31 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48512 |
461 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
14.74 |
ml/min/kg |
1.19 |
3.76 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59977 |
526 |
FHH-Chr 12BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
12 |
|
51.08 |
% |
0.54 |
1.87 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38976 |
401 |
FHH-Chr 12BN/Mcwi |
lung dry weight to body weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
lung mass |
male |
77 days-91 days |
12 |
|
1.0 |
g/kg |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59453 |
526 |
FHH-Chr 12BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
11 |
|
55.15 |
% |
0.58 |
1.93 |
microhematocrit tube assay with visual assessment |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59248 |
526 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
11 |
|
-8.09 |
null |
0.08 |
0.28 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55249 |
522 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
21.34 |
ml/min/kg |
0.88 |
2.8 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57791 |
526 |
FHH-Chr 12BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
female |
77 days-91 days |
12 |
|
4.37 |
mmol/l |
0.16 |
0.56 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38051 |
401 |
FHH-Chr 12BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
12 |
|
143.58 |
mmol/l |
0.26 |
0.9 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39373 |
401 |
FHH-Chr 12BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
17 |
|
91.43 |
breaths/min |
2.24 |
9.22 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14920 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
19 |
|
116.49 |
breaths/min |
4.28 |
18.65 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14779 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
231.99 |
% |
10.97 |
45.25 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14183 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
189.43 |
% |
10.79 |
34.12 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14189 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
17 |
|
122.37 |
mmHg |
3.52 |
14.5 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14302 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
10 |
|
115.03 |
mmHg |
2.48 |
7.83 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13469 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
15 |
|
116.61 |
mmHg |
4.2 |
16.27 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19840 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
107.2 |
% |
7.1 |
23.56 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53874 |
381 |
FHH-Chr 12BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
19 |
|
92.0 |
breaths/min |
3.0 |
13.06 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18395 |
381 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
58.76 |
ml/min |
2.91 |
11.98 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14485 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
0.24 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13908 |
381 |
FHH-Chr 12BN/Mcwi |
serum alkaline phosphatase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
11 |
|
240.91 |
U/l |
9.71 |
32.19 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37433 |
401 |
FHH-Chr 12BN/Mcwi |
serum sodium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
12 |
|
144.25 |
mmol/l |
0.85 |
2.96 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36489 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
%change=VE during7-9 min hypercapnia/control during standard conditions |
126.57 |
% |
7.89 |
34.39 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18528 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
19 |
|
-0.29 |
degrees C |
0.12 |
0.54 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20294 |
381 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin concentration |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
11 |
|
32.23 |
g/dl |
0.31 |
1.02 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37311 |
401 |
FHH-Chr 12BN/Mcwi |
time to peak heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
12 |
|
1139.92 |
s |
62.15 |
215.29 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
50218 |
461 |
FHH-Chr 12BN/Mcwi |
blood neutrophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
female |
77 days-91 days |
11 |
|
0.51 |
x 1000 cells/ul |
0.1 |
0.33 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38879 |
401 |
FHH-Chr 12BN/Mcwi |
blood neutrophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
neutrophil quantity |
male |
77 days-91 days |
12 |
|
0.97 |
x 1000 cells/ul |
0.09 |
0.32 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38895 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
11 |
|
17.95 |
pg |
0.07 |
0.24 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42536 |
401 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
12 |
|
0.26 |
mg/dl |
0.02 |
0.07 |
automated plasma creatinine analysis |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39561 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
11 |
|
32.27 |
g/dl |
0.07 |
0.24 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39768 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
12 |
|
16.76 |
pg |
0.08 |
0.29 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40197 |
401 |
FHH-Chr 12BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
11 |
|
1.93 |
mg/kg |
0.35 |
1.16 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58891 |
526 |
FHH-Chr 12BN/Mcwi |
serum albumin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
12 |
|
3.59 |
g/dl |
0.08 |
0.28 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40406 |
401 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
12 |
|
157.8 |
g |
3.4 |
11.7 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59047 |
526 |
FHH-Chr 12BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
12 |
|
0.06 |
mmHg-1 |
0.01 |
0.03 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59357 |
526 |
FHH-Chr 12BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
female |
77 days-91 days |
12 |
|
2.02 |
g/dl |
0.03 |
0.1 |
standard blood chemistry panel |
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40535 |
401 |
FHH-Chr 12BN/Mcwi |
serum globulin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood globulin amount |
male |
77 days-91 days |
11 |
|
2.1 |
g/dl |
0.05 |
0.17 |
standard blood chemistry panel |
|
0 |
|
replaced obsolete serum globulin level term, 1/19/2016 |
Moms and pups used in studies were fed Teklad |
40541 |
401 |
FHH-Chr 12BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
12 |
|
43.73 |
% |
1.02 |
3.52 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41301 |
401 |
FHH-Chr 12BN/Mcwi |
blood eosinophil count |
control condition (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
11 |
|
0.04 |
x 1000 cells/ul |
0.01 |
0.04 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41387 |
401 |
FHH-Chr 12BN/Mcwi |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
9 |
|
0.4 |
null |
0.02 |
0.07 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59772 |
526 |
FHH-Chr 12BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
11 |
|
17.8 |
g/dl |
0.18 |
0.58 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37959 |
401 |
FHH-Chr 12BN/Mcwi |
serum total cholesterol level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
male |
77 days-91 days |
12 |
|
100.08 |
mg/dl |
3.64 |
12.62 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38432 |
401 |
FHH-Chr 12BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
18 |
|
7.35 |
g/kg |
0.2 |
0.85 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45590 |
461 |
FHH-Chr 12BN/Mcwi |
time to peak heart contraction |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
22 |
|
1144.4 |
s |
60.82 |
285.28 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46533 |
461 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
11 |
|
-7.73 |
null |
0.07 |
0.23 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
55265 |
522 |
FHH-Chr 12BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
male |
77 days-91 days |
12 |
|
43.73 |
% |
1.02 |
3.52 |
microhematocrit tube assay with visual assessment |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57486 |
526 |
FHH-Chr 12BN/Mcwi |
maximum contractile force per wet weight of aorta |
controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
17 |
|
1.16 |
g/mg |
0.09 |
0.36 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57324 |
522 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
11 |
post-ischemic value/pre-ischemic value x 100% |
73.96 |
% |
7.93 |
26.31 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48747 |
461 |
FHH-Chr 12BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
11 |
|
36.43 |
degrees C |
0.21 |
0.68 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16563 |
381 |
FHH-Chr 12BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
19 |
|
36.87 |
degrees C |
0.38 |
1.64 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16797 |
381 |
FHH-Chr 12BN/Mcwi |
body temperature |
control condition |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
11 |
|
36.76 |
degrees C |
0.27 |
0.9 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16803 |
381 |
FHH-Chr 12BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
0.06 |
10E-7mol/l |
0.01 |
0.02 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55743 |
522 |
FHH-Chr 12BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
11 |
|
0.02 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54664 |
522 |
FHH-Chr 12BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
12 |
|
0.04 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58474 |
526 |
FHH-Chr 12BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
0.07 |
10E-7mol/l |
0.05 |
0.08 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56227 |
522 |
FHH-Chr 12BN/Mcwi |
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
0.05 |
10E-7mol/l |
0.01 |
0.04 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56238 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
15.33 |
% |
4.1 |
7.09 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56270 |
522 |
FHH-Chr 12BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
93.67 |
% |
6.33 |
10.97 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56302 |
522 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
female |
70 days-84 days |
13 |
|
180.7 |
g |
1.7 |
6.1 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55159 |
522 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled sodium content diet (4 %) (for 21 days) |
PhysGen Vascular data |
body mass |
male |
70 days-84 days |
17 |
|
247.3 |
g |
4.9 |
20.4 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55173 |
522 |
FHH-Chr 12BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
12 |
|
0.12 |
mmHg x min x kg x ml-1 |
0.0 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59887 |
526 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
control condition |
PhysGen Respiratory data |
blood carbon dioxide amount |
male |
82 days-99 days |
11 |
|
34.27 |
mmHg |
1.2 |
3.97 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16053 |
381 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
14 |
|
5.93 |
ml/min/g |
0.73 |
2.74 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44703 |
461 |
FHH-Chr 12BN/Mcwi |
heart weight to body weight ratio |
control condition |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
21 |
|
5.31 |
g/kg |
0.17 |
0.79 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46965 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
20 |
post-ischemic value/pre-ischemic value x 100% |
66.78 |
% |
5.28 |
23.63 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46057 |
461 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
female |
82 days-99 days |
17 |
|
127.74 |
mmHg |
4.23 |
17.45 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15064 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
11 |
|
115.85 |
% |
6.55 |
21.74 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53742 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
0.23 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17967 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
6 |
post-ischemic value/pre-ischemic value x 100% |
49.03 |
% |
9.3 |
22.78 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46304 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
5 |
post-ischemic value/pre-ischemic value x 100% |
42.81 |
% |
12.58 |
28.12 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46310 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
9 |
|
143.49 |
mmHg |
10.46 |
31.39 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45720 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
22 |
|
46.95 |
mmHg |
3.14 |
14.71 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47686 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
19 |
|
52.11 |
mmHg |
4.17 |
18.17 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47902 |
461 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
20 |
|
8.4 |
ml/min/g |
0.4 |
1.79 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46861 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
19 |
|
99.67 |
mmHg |
3.55 |
15.47 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44806 |
461 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
19 |
|
21.46 |
ml/min |
1.05 |
4.56 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16675 |
381 |
FHH-Chr 12BN/Mcwi |
plasma anion gap |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
11 |
|
24.09 |
mmol/l |
0.67 |
2.21 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38252 |
401 |
FHH-Chr 12BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
male |
49 days-63 days |
19 |
|
5.47 |
% |
1.56 |
6.8 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49387 |
461 |
FHH-Chr 12BN/Mcwi |
serum bicarbonate level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bicarbonate amount |
female |
77 days-91 days |
11 |
|
19.45 |
mmol/l |
0.59 |
1.97 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42973 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
137.27 |
% |
7.63 |
24.13 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54414 |
381 |
FHH-Chr 12BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
16 |
|
9.38 |
% |
3.21 |
12.83 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49683 |
461 |
FHH-Chr 12BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
11 |
|
2.18 |
mg/kg |
0.48 |
1.6 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58897 |
526 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
5 |
|
111.93 |
mmHg |
2.53 |
5.66 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48609 |
461 |
FHH-Chr 12BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
12 |
|
1.57 |
E-7mole |
0.18 |
0.63 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56494 |
522 |
FHH-Chr 12BN/Mcwi |
serum urea nitrogen level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
11 |
|
21.64 |
mg/dl |
0.95 |
3.14 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40819 |
401 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
28.37 |
ml/min |
2.42 |
7.65 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16138 |
381 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
11 |
|
14.25 |
ml/min/kg |
0.62 |
2.05 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59993 |
526 |
FHH-Chr 12BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
12 |
|
0.24 |
null |
0.01 |
0.03 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57884 |
526 |
FHH-Chr 12BN/Mcwi |
urine potassium excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine potassium amount |
male |
80 days-99 days |
11 |
|
1.07 |
mEq/d |
0.06 |
0.21 |
flame atomic emission spectrometry |
|
0 |
urine potassium analysis |
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52311 |
482 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
heart pumping trait |
female |
80 days-99 days |
11 |
|
435.43 |
beats/min |
9.42 |
31.23 |
vascular fluid filled catheter |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52484 |
482 |
FHH-Chr 12BN/Mcwi |
absolute change in blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
0.04 |
null |
0.0 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19768 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
control condition |
PhysGen Respiratory data |
heart pumping trait |
female |
82 days-99 days |
17 |
|
407.29 |
beats/min |
10.17 |
41.93 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20893 |
381 |
FHH-Chr 12BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
male |
77 days-91 days |
11 |
|
412.27 |
U/l |
8.23 |
27.3 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36370 |
401 |
FHH-Chr 12BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
12 |
|
7.48 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17020 |
381 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood oxygen |
control condition |
PhysGen Respiratory data |
blood oxygen amount |
female |
82 days-99 days |
13 |
|
103.25 |
mmHg |
2.21 |
7.95 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18840 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
17 |
|
-0.35 |
degrees C |
0.12 |
0.48 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15654 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
154.81 |
% |
3.65 |
15.05 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54068 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
153.98 |
% |
7.8 |
24.66 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54074 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
17 |
|
154.72 |
% |
4.39 |
18.1 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54202 |
381 |
FHH-Chr 12BN/Mcwi |
serum calcium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
12 |
|
9.75 |
mg/dl |
0.09 |
0.32 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36609 |
401 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
11 |
|
411.34 |
beats/min |
11.45 |
37.98 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17487 |
381 |
FHH-Chr 12BN/Mcwi |
serum sodium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
female |
77 days-91 days |
11 |
|
144.91 |
mmol/l |
0.74 |
2.47 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36473 |
401 |
FHH-Chr 12BN/Mcwi |
serum calcium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
male |
77 days-91 days |
12 |
|
10.06 |
mg/dl |
0.16 |
0.57 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36758 |
401 |
FHH-Chr 12BN/Mcwi |
absolute change in body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
11 |
|
-0.34 |
degrees C |
0.11 |
0.36 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20300 |
381 |
FHH-Chr 12BN/Mcwi |
heart wet weight |
control condition |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
21 |
|
0.73 |
g |
0.03 |
0.14 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49045 |
461 |
FHH-Chr 12BN/Mcwi |
time to onset of heart contraction |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
12 |
|
909.5 |
s |
58.4 |
202.32 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49290 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
106.78 |
mmHg |
9.73 |
30.76 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49879 |
461 |
FHH-Chr 12BN/Mcwi |
serum aspartate aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
female |
77 days-91 days |
11 |
|
84.27 |
U/l |
4.77 |
15.81 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42400 |
401 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
female |
77 days-91 days |
11 |
|
0.18 |
mg/dl |
0.02 |
0.06 |
automated plasma creatinine analysis |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42629 |
401 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood creatinine amount |
male |
77 days-91 days |
12 |
|
0.18 |
mg/dl |
0.03 |
0.09 |
automated plasma creatinine analysis |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42645 |
401 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
19 |
|
127.71 |
% |
3.97 |
17.31 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54309 |
381 |
FHH-Chr 12BN/Mcwi |
serum potassium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
11 |
|
4.77 |
mmol/l |
0.11 |
0.37 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43326 |
401 |
FHH-Chr 12BN/Mcwi |
serum total bilirubin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
male |
77 days-91 days |
12 |
|
0.1 |
mg/dl |
0.0 |
0.0 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42882 |
401 |
FHH-Chr 12BN/Mcwi |
blood hemoglobin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
12 |
|
16.41 |
g/dl |
0.18 |
0.64 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37953 |
401 |
FHH-Chr 12BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
12 |
|
0.19 |
mmHg x min x kg x ml-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59538 |
526 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
7 |
|
115.52 |
mmHg |
5.96 |
15.78 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45489 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
12 |
post-ischemic value/pre-ischemic value x 100% |
82.98 |
% |
8.82 |
30.56 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48741 |
461 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
-6.77 |
null |
0.11 |
0.38 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55599 |
522 |
FHH-Chr 12BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
12 |
|
0.24 |
null |
0.01 |
0.02 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57900 |
526 |
FHH-Chr 12BN/Mcwi |
FAPGG metabolism-surface area product |
controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
43.78 |
ml/min/kg |
3.48 |
10.99 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57990 |
526 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
-7.15 |
null |
0.05 |
0.16 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55615 |
522 |
FHH-Chr 12BN/Mcwi |
maximum contractile force per wet weight of aorta |
potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
11 |
|
1.27 |
g/mg |
0.06 |
0.21 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55778 |
522 |
FHH-Chr 12BN/Mcwi |
FAPGG metabolism-surface area product |
FAPGG (0.6 mmol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
10 |
|
51.47 |
ml/min/kg |
2.39 |
7.54 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58226 |
526 |
FHH-Chr 12BN/Mcwi |
body temperature |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
19 |
|
36.58 |
degrees C |
0.4 |
1.76 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16557 |
381 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
13.33 |
% |
7.97 |
13.8 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55070 |
522 |
FHH-Chr 12BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
female |
77 days-91 days |
12 |
|
0.49 |
null |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58718 |
526 |
FHH-Chr 12BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
0.35 |
ml |
0.01 |
0.04 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17361 |
381 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
control condition |
PhysGen Respiratory data |
blood carbon dioxide amount |
female |
82 days-99 days |
13 |
|
37.04 |
mmHg |
0.85 |
3.07 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16042 |
381 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
22 |
|
10.05 |
ml/min/g |
0.55 |
2.58 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46855 |
461 |
FHH-Chr 12BN/Mcwi |
heart weight to body weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
12 |
|
7.27 |
g/kg |
0.45 |
1.57 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45606 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
11 |
|
121.86 |
mmHg |
4.68 |
15.53 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45714 |
461 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
14 |
|
10.71 |
ml/min/g |
0.51 |
1.92 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46638 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
19 |
|
47.56 |
mmHg |
3.76 |
16.41 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47692 |
461 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition |
PhysGen Cardiac data |
body mass |
female |
49 days-63 days |
22 |
|
139.2 |
g |
4.7 |
22.2 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47787 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular diastolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
9 |
|
5.91 |
mmHg |
0.14 |
0.41 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47182 |
461 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
21 |
|
0.4 |
IU/g |
0.05 |
0.23 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47280 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
15 |
post-ischemic value/pre-ischemic value x 100% |
70.13 |
% |
8.72 |
33.78 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48280 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
12 |
post-ischemic value/pre-ischemic value x 100% |
89.28 |
% |
19.25 |
66.69 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48286 |
461 |
FHH-Chr 12BN/Mcwi |
heart contraction pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
male |
49 days-63 days |
21 |
|
40.57 |
mmHg |
2.31 |
10.57 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48024 |
461 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
female |
49 days-63 days |
22 |
|
6.55 |
ml/min/g |
0.57 |
2.66 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46186 |
461 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
50.59 |
ml/min |
2.24 |
9.24 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20746 |
381 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood oxygen |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood oxygen amount |
male |
82 days-99 days |
11 |
|
56.49 |
mmHg |
1.9 |
6.3 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20459 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
0.26 |
ml |
0.02 |
0.05 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15388 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
11 |
|
119.18 |
mmHg |
4.58 |
15.19 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14314 |
381 |
FHH-Chr 12BN/Mcwi |
partial pressure of blood carbon dioxide (Pco2) |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood gas amount |
male |
82 days-99 days |
11 |
|
30.22 |
mmHg |
0.8 |
2.67 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
17226 |
381 |
FHH-Chr 12BN/Mcwi |
percent change in arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
12 |
post-ischemic value/pre-ischemic value x 100% |
30.85 |
% |
5.02 |
17.38 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47068 |
461 |
FHH-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
male |
80 days-99 days |
10 |
|
1.33 |
ml/min |
0.14 |
0.44 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52358 |
482 |
FHH-Chr 12BN/Mcwi |
urine albumin excretion rate |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
urine albumin amount |
female |
80 days-99 days |
10 |
|
45.57 |
mg/d |
19.51 |
61.71 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52386 |
482 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
female |
80 days-99 days |
7 |
|
0.36 |
mg/dl |
0.04 |
0.11 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52243 |
482 |
FHH-Chr 12BN/Mcwi |
percent change in heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
female |
49 days-63 days |
22 |
post-ischemic value/pre-ischemic value x 100% |
85.53 |
% |
5.42 |
25.43 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48391 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
22 |
|
97.97 |
mmHg |
3.82 |
17.93 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
44800 |
461 |
FHH-Chr 12BN/Mcwi |
blood lymphocyte count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
lymphocyte quantity |
male |
77 days-91 days |
11 |
|
4.4 |
x 1000 cells/ul |
0.39 |
1.28 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41494 |
401 |
FHH-Chr 12BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
11 |
|
2.29 |
E-7mole |
0.56 |
1.86 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55868 |
522 |
FHH-Chr 12BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
female |
77 days-91 days |
12 |
|
0.04 |
x 1000 cells/ul |
0.01 |
0.05 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41632 |
401 |
FHH-Chr 12BN/Mcwi |
blood eosinophil count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
eosinophil quantity |
male |
77 days-91 days |
11 |
|
0.05 |
x 1000 cells/ul |
0.02 |
0.06 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41638 |
401 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
-8.38 |
null |
0.31 |
0.54 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56015 |
522 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
8 |
|
140.05 |
mmHg |
11.43 |
32.33 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48615 |
461 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
12 |
|
193.3 |
g |
3.2 |
11.1 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59053 |
526 |
FHH-Chr 12BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
female |
77 days-91 days |
12 |
|
111.08 |
mmol/l |
0.26 |
0.9 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39102 |
401 |
FHH-Chr 12BN/Mcwi |
serum chloride level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood chloride amount |
male |
77 days-91 days |
11 |
|
110.64 |
mmol/l |
0.36 |
1.21 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39108 |
401 |
FHH-Chr 12BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
12 |
|
0.19 |
mmHg x min x kg x ml-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59532 |
526 |
FHH-Chr 12BN/Mcwi |
serum albumin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
male |
77 days-91 days |
11 |
|
3.77 |
g/dl |
0.03 |
0.1 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42224 |
401 |
FHH-Chr 12BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
11 |
|
55.15 |
% |
0.58 |
1.93 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38982 |
401 |
FHH-Chr 12BN/Mcwi |
total white blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
male |
77 days-91 days |
11 |
|
5.58 |
x 1000 cells/ul |
0.44 |
1.47 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40917 |
401 |
FHH-Chr 12BN/Mcwi |
lung dry weight to body weight ratio |
control condition (for 14 days) |
PhysGen Lung data |
lung mass |
female |
77 days-91 days |
12 |
|
1.13 |
g/kg |
0.02 |
0.07 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59437 |
526 |
FHH-Chr 12BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
12 |
|
8.97 |
x 10E6 cells/ul |
0.1 |
0.33 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39222 |
401 |
FHH-Chr 12BN/Mcwi |
hematocrit |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
11 |
|
42.43 |
% |
0.82 |
2.71 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41285 |
401 |
FHH-Chr 12BN/Mcwi |
respiration rate |
control condition |
PhysGen Respiratory data |
respiratory function trait |
male |
82 days-99 days |
10 |
|
107.63 |
breaths/min |
4.0 |
12.65 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14926 |
381 |
FHH-Chr 12BN/Mcwi |
plasma creatinine level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
blood creatinine amount |
male |
80 days-99 days |
10 |
|
0.37 |
mg/dl |
0.03 |
0.08 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52262 |
482 |
FHH-Chr 12BN/Mcwi |
plasma renin activity level |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
renin activity |
male |
80 days-99 days |
10 |
|
1.71 |
ng/ml/h |
0.17 |
0.52 |
radioimmunoassay |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52897 |
482 |
FHH-Chr 12BN/Mcwi |
body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
female |
82 days-99 days |
17 |
|
36.87 |
degrees C |
0.1 |
0.42 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13544 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
11 |
|
125.99 |
mmHg |
3.59 |
11.91 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15076 |
381 |
FHH-Chr 12BN/Mcwi |
heart rate |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
heart pumping trait |
male |
82 days-99 days |
10 |
|
330.03 |
beats/min |
14.67 |
46.39 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
14682 |
381 |
FHH-Chr 12BN/Mcwi |
absolute change in body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
10 |
|
-0.05 |
degrees C |
0.31 |
1.0 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
15660 |
381 |
FHH-Chr 12BN/Mcwi |
tidal volume |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
11 |
|
0.26 |
ml |
0.01 |
0.05 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13914 |
381 |
FHH-Chr 12BN/Mcwi |
mean arterial blood pressure |
control condition |
PhysGen Respiratory data |
arterial blood pressure trait |
male |
82 days-99 days |
10 |
|
119.12 |
mmHg |
2.99 |
9.44 |
vascular fluid filled catheter |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19850 |
381 |
FHH-Chr 12BN/Mcwi |
blood pH |
control condition |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
female |
82 days-99 days |
13 |
|
7.42 |
null |
0.01 |
0.02 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20596 |
381 |
FHH-Chr 12BN/Mcwi |
blood pH |
control condition |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
7.45 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
20607 |
381 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition |
PhysGen Respiratory data |
body mass |
female |
82 days-99 days |
19 |
|
177.3 |
g |
2.6 |
11.5 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
17802 |
381 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition |
PhysGen Respiratory data |
body mass |
male |
82 days-99 days |
11 |
|
249.4 |
g |
3.5 |
11.5 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Dyets |
17808 |
381 |
FHH-Chr 12BN/Mcwi |
serum alkaline phosphatase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood alkaline phosphatase amount |
female |
77 days-91 days |
12 |
|
286.33 |
U/l |
7.3 |
25.29 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36364 |
401 |
FHH-Chr 12BN/Mcwi |
blood pH |
controlled air oxygen content (12 %) (for 0.1 hours) |
PhysGen Respiratory data |
blood acidity-alkalinity balance trait |
male |
82 days-99 days |
11 |
|
7.49 |
null |
0.01 |
0.03 |
automated blood gas analysis using a Bayer analyzer |
|
0 |
|
|
Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks |
17032 |
381 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin concentration |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
male |
77 days-91 days |
12 |
|
32.02 |
g/dl |
0.14 |
0.49 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37327 |
401 |
FHH-Chr 12BN/Mcwi |
serum calcium level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood calcium amount |
female |
77 days-91 days |
11 |
|
9.47 |
mg/dl |
0.12 |
0.38 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
36742 |
401 |
FHH-Chr 12BN/Mcwi |
respiration rate |
controlled air oxygen content (12 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
19 |
|
116.69 |
breaths/min |
4.07 |
17.75 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
18250 |
381 |
FHH-Chr 12BN/Mcwi |
body weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
body mass |
male |
49 days-63 days |
12 |
|
169.2 |
g |
6.0 |
20.7 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49508 |
461 |
FHH-Chr 12BN/Mcwi |
serum aspartate aminotransferase activity level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
12 |
|
103.25 |
U/l |
5.3 |
18.36 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42416 |
401 |
FHH-Chr 12BN/Mcwi |
serum aspartate aminotransferase activity level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood aspartate transaminase amount |
male |
77 days-91 days |
11 |
|
91.82 |
U/l |
3.43 |
11.39 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
42761 |
401 |
FHH-Chr 12BN/Mcwi |
red blood cell count |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
11 |
|
9.93 |
x 10E6 cells/ul |
0.12 |
0.4 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39228 |
401 |
FHH-Chr 12BN/Mcwi |
total white blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
leukocyte quantity |
female |
77 days-91 days |
11 |
|
3.65 |
x 1000 cells/ul |
0.24 |
0.8 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39868 |
401 |
FHH-Chr 12BN/Mcwi |
mean corpuscular hemoglobin concentration |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood hemoglobin amount |
female |
77 days-91 days |
12 |
|
32.12 |
g/dl |
0.1 |
0.36 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39762 |
401 |
FHH-Chr 12BN/Mcwi |
plasma anion gap |
control condition (for 14 days) |
PhysGen Biochemistry data |
ion homeostasis trait |
male |
77 days-91 days |
11 |
|
23.27 |
mmol/l |
0.68 |
2.24 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
43130 |
401 |
FHH-Chr 12BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
female |
77 days-91 days |
10 |
|
2.1 |
mg/kg |
0.49 |
1.55 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59148 |
526 |
FHH-Chr 12BN/Mcwi |
dose of methacholine at which pulmonary conductance is half its pretreatment value |
methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) |
PhysGen Lung data |
pulmonary ventilation trait |
male |
77 days-91 days |
11 |
|
2.74 |
mg/kg |
0.26 |
0.85 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59164 |
526 |
FHH-Chr 12BN/Mcwi |
percent change in respiration rate |
controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) |
PhysGen Respiratory data |
respiratory function trait |
female |
82 days-99 days |
19 |
|
129.03 |
% |
6.28 |
27.38 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
53736 |
381 |
FHH-Chr 12BN/Mcwi |
blood monocyte count |
control condition (for 14 days) |
PhysGen Biochemistry data |
monocyte quantity |
female |
77 days-91 days |
11 |
|
0.21 |
x 1000 cells/ul |
0.05 |
0.17 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40277 |
401 |
FHH-Chr 12BN/Mcwi |
serum albumin level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood albumin amount |
female |
77 days-91 days |
11 |
|
3.71 |
g/dl |
0.07 |
0.23 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
40390 |
401 |
FHH-Chr 12BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
female |
77 days-91 days |
11 |
|
0.05 |
mmHg-1 |
0.01 |
0.02 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59341 |
526 |
FHH-Chr 12BN/Mcwi |
serum phosphate level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood phosphate amount |
male |
77 days-91 days |
11 |
|
8.2 |
mg/dl |
0.18 |
0.59 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37585 |
401 |
FHH-Chr 12BN/Mcwi |
serum potassium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood potassium amount |
male |
77 days-91 days |
11 |
|
5.26 |
mmol/l |
0.16 |
0.52 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38057 |
401 |
FHH-Chr 12BN/Mcwi |
serum total cholesterol level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
11 |
|
90.0 |
mg/dl |
2.43 |
8.06 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38416 |
401 |
FHH-Chr 12BN/Mcwi |
serum urea nitrogen level |
control condition (for 14 days) |
PhysGen Biochemistry data |
blood urea nitrogen amount |
male |
77 days-91 days |
12 |
|
15.17 |
mg/dl |
1.02 |
3.54 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41751 |
401 |
FHH-Chr 12BN/Mcwi |
serum glucose level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood glucose amount |
male |
77 days-91 days |
11 |
|
150.18 |
mg/dl |
6.18 |
20.5 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
38521 |
401 |
FHH-Chr 12BN/Mcwi |
red blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
female |
77 days-91 days |
11 |
|
7.84 |
x 10E6 cells/ul |
0.15 |
0.51 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41952 |
401 |
FHH-Chr 12BN/Mcwi |
red blood cell count |
control condition (for 14 days) |
PhysGen Biochemistry data |
erythrocyte quantity |
male |
77 days-91 days |
12 |
|
8.36 |
x 10E6 cells/ul |
0.21 |
0.72 |
automated blood cell counting method |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41968 |
401 |
FHH-Chr 12BN/Mcwi |
serum total bilirubin level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood bilirubin amount |
female |
77 days-91 days |
12 |
|
0.12 |
mg/dl |
0.01 |
0.04 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
41853 |
401 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
17 |
|
213.78 |
beats/min |
8.8 |
36.3 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48936 |
461 |
FHH-Chr 12BN/Mcwi |
minute ventilation |
control condition |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
|
22.15 |
ml/min |
0.85 |
3.52 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16132 |
381 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
10 |
|
26.38 |
IU/g |
3.42 |
10.8 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48838 |
461 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
8 |
|
22.77 |
IU/g |
2.45 |
6.93 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48849 |
461 |
FHH-Chr 12BN/Mcwi |
tidal volume |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
male |
82 days-99 days |
10 |
|
0.39 |
ml |
0.02 |
0.06 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
16464 |
381 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition (for 14 days) |
PhysGen Lung data |
body mass |
male |
77 days-91 days |
12 |
|
226.5 |
g |
7.3 |
25.2 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58337 |
526 |
FHH-Chr 12BN/Mcwi |
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
female |
70 days-84 days |
12 |
|
0.01 |
umol/l |
0.0 |
0.01 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54880 |
522 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
-8.28 |
null |
0.04 |
0.14 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54617 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
18.0 |
% |
3.53 |
9.33 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56281 |
522 |
FHH-Chr 12BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
12 |
|
70.75 |
% |
7.19 |
24.91 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
54754 |
522 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) |
PhysGen Vascular data |
vasoconstriction trait |
male |
70 days-84 days |
17 |
|
-8.49 |
null |
0.16 |
0.66 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
EC50 value is moles/liter |
Moms and pups used in studies were fed Teklad |
56095 |
522 |
FHH-Chr 12BN/Mcwi |
heart right ventricle weight to left ventricle weight ratio |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
heart right ventricle mass |
male |
77 days-91 days |
11 |
|
0.52 |
null |
0.02 |
0.08 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58724 |
526 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
14.7 |
% |
3.41 |
10.78 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55141 |
522 |
FHH-Chr 12BN/Mcwi |
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
1.46 |
E-7mole |
0.27 |
1.09 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56510 |
522 |
FHH-Chr 12BN/Mcwi |
calculated pulmonary vascular resistance normalized to body weight |
Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
11 |
|
0.11 |
mmHg x min x kg x ml-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59871 |
526 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77 days-91 days |
10 |
|
22.9 |
ml/min/kg |
1.5 |
4.75 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58606 |
526 |
FHH-Chr 12BN/Mcwi |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77 days-91 days |
11 |
|
20.54 |
ml/min/kg |
0.78 |
2.6 |
isolated perfused lung vascular effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58622 |
526 |
FHH-Chr 12BN/Mcwi |
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
16 |
|
-6.99 |
null |
0.11 |
0.44 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56905 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
30.0 |
% |
2.31 |
4.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57133 |
522 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 1.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
5 |
|
20.8 |
IU/g |
5.77 |
12.9 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45949 |
461 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
male |
49 days-63 days |
12 |
|
0.34 |
IU/g |
0.03 |
0.1 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47438 |
461 |
FHH-Chr 12BN/Mcwi |
heart rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
10 |
|
259.58 |
beats/min |
49.97 |
158.03 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45139 |
461 |
FHH-Chr 12BN/Mcwi |
percent change in heart rate |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart pumping trait |
male |
49 days-63 days |
20 |
post-ischemic value/pre-ischemic value x 100% |
105.43 |
% |
17.47 |
78.11 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
48397 |
461 |
FHH-Chr 12BN/Mcwi |
body temperature |
air carbon dioxide content (7 %) (for 0.1 hours) |
PhysGen Respiratory data |
body temperature trait |
male |
82 days-99 days |
10 |
|
36.64 |
degrees C |
0.15 |
0.47 |
digital rectal thermometry |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
13550 |
381 |
FHH-Chr 12BN/Mcwi |
serum total cholesterol level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood cholesterol amount |
female |
77 days-91 days |
12 |
|
75.25 |
mg/dl |
1.64 |
5.69 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
37082 |
401 |
FHH-Chr 12BN/Mcwi |
creatinine clearance |
controlled sodium content diet (8 %) (between 19 and 22 days) and controlled NG-nitroarginine methyl ester content drinking water (12.5 mg/l) (between 19 and 22 days) |
PhysGen Renal B data |
glomerular filtration trait |
female |
80 days-99 days |
7 |
|
1.1 |
ml/min |
0.19 |
0.5 |
urine creatinine analysis |
|
0 |
|
|
Moms were fed Teklad, pups used in studies were fed Dyets |
52339 |
482 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
14 |
|
50.37 |
mmHg |
5.31 |
19.87 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45255 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular developed pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
10 |
|
47.22 |
mmHg |
8.01 |
25.34 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45261 |
461 |
FHH-Chr 12BN/Mcwi |
heart effluent lactate dehydrogenase activity level normalized to heart weight |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart lactate dehydrogenase activity |
female |
49 days-63 days |
16 |
|
0.29 |
IU/g |
0.06 |
0.24 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
47422 |
461 |
FHH-Chr 12BN/Mcwi |
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
54.45 |
% |
4.67 |
15.49 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57214 |
522 |
FHH-Chr 12BN/Mcwi |
arterial blood flow rate |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
arterial blood flow trait |
male |
49 days-63 days |
12 |
|
11.57 |
ml/min/g |
0.41 |
1.43 |
isolated perfused heart effluent collection |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
46644 |
461 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
38.67 |
% |
4.33 |
7.51 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57165 |
522 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
10 |
|
52.7 |
% |
2.58 |
8.15 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
57176 |
522 |
FHH-Chr 12BN/Mcwi |
heart left ventricle infarction weight to total heart left ventricle weight ratio |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) |
PhysGen Cardiac data |
heart left ventricle integrity trait |
female |
49 days-63 days |
21 |
|
9.88 |
% |
1.37 |
6.26 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49381 |
461 |
FHH-Chr 12BN/Mcwi |
body weight |
control condition (for 14 days) |
PhysGen Lung data |
body mass |
female |
77 days-91 days |
12 |
|
163.8 |
g |
3.5 |
12.3 |
whole body digital scale |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58321 |
526 |
FHH-Chr 12BN/Mcwi |
fractional change in blood vessel diameter per unit change in intravascular pressure |
controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) |
PhysGen Lung data |
blood vessel distensibility trait |
male |
77 days-91 days |
12 |
|
0.04 |
mmHg-1 |
0.0 |
0.01 |
fluid-filled catheter with pressure transducer in isolated perfused lung |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
58480 |
526 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
female |
49 days-63 days |
14 |
|
102.81 |
mmHg |
5.11 |
19.13 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49873 |
461 |
FHH-Chr 12BN/Mcwi |
heart contraction pressure |
controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) |
PhysGen Cardiac data |
heart muscle contractility trait |
female |
49 days-63 days |
16 |
|
38.56 |
mmHg |
2.77 |
11.09 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
49982 |
461 |
FHH-Chr 12BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
7 |
|
99.14 |
% |
0.7 |
1.86 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56313 |
522 |
FHH-Chr 12BN/Mcwi |
percent change in ventilation |
air carbon dioxide content (7 %) (between 0 and 0.1 hours) |
PhysGen Respiratory data |
pulmonary ventilation trait |
female |
82 days-99 days |
17 |
%change=VE during 2-3 min hypercapnia/control during standard conditions |
267.82 |
% |
11.48 |
47.35 |
stop flow air displacement plethysmography |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
19196 |
381 |
FHH-Chr 12BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
female |
49 days-63 days |
18 |
|
1.01 |
g |
0.02 |
0.1 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45390 |
461 |
FHH-Chr 12BN/Mcwi |
heart wet weight |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Cardiac data |
heart mass |
male |
49 days-63 days |
12 |
|
1.21 |
g |
0.04 |
0.13 |
digital scale post excision weight measurement |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45396 |
461 |
FHH-Chr 12BN/Mcwi |
left ventricular systolic blood pressure |
controlled oxygen content Kreb's solution perfusate (for 0.5 hours) |
PhysGen Cardiac data |
heart left ventricular blood pressure trait |
male |
49 days-63 days |
5 |
|
108.7 |
mmHg |
3.14 |
7.01 |
balloon tipped catheter with pressure transducer in isolated perfused heart |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
45495 |
461 |
FHH-Chr 12BN/Mcwi |
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
12.33 |
% |
3.38 |
5.86 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
55042 |
522 |
FHH-Chr 12BN/Mcwi |
hematocrit |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Lung data |
erythrocyte quantity |
female |
77 days-91 days |
12 |
|
51.08 |
% |
0.54 |
1.87 |
microhematocrit tube assay with visual assessment |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
59242 |
526 |
FHH-Chr 12BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
female |
70 days-84 days |
3 |
|
100.0 |
% |
0.0 |
0.0 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56462 |
522 |
FHH-Chr 12BN/Mcwi |
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel |
phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) |
PhysGen Vascular data |
vasodilation trait |
male |
70 days-84 days |
11 |
|
99.45 |
% |
0.28 |
0.93 |
wire myography using a Digi-Med tissue force analysis system with force transducer |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
56473 |
522 |
FHH-Chr 12BN/Mcwi |
serum sodium level |
controlled air oxygen content (12 %) (for 14 days) |
PhysGen Biochemistry data |
blood sodium amount |
male |
77 days-91 days |
11 |
|
143.09 |
mmol/l |
0.34 |
1.14 |
standard blood chemistry panel |
|
0 |
|
|
Moms and pups used in studies were fed Teklad |
39379 |
401 |