BBDR/Rhw |
post-insult time to onset of diabetes mellitus |
anti-RT6.1 antibody (2 ml) (for 28 days) and poly I:C (5 ug/g) (for 28 days) |
Martin AM, et al., Diabetes 1999 Nov;48(11):2138-44 |
glucose metabolism trait |
not specified |
0 days-70 days |
12 |
|
11.0 |
d |
1.0 |
3.46 |
blood glucose analysis |
0.0 |
injection |
0 |
anti-RT6.1mAB and poly I:C |
|
66148 |
711 |
BBDR/Rhw |
blood CD4 cell to R73 cell ratio |
specific pathogen-free condition |
Fuller JM, et al., Physiol Genomics. 2009 Apr 7. |
T cell quantity |
not specified |
25 days-30 days |
75 |
median |
75.0 |
% |
|
|
fluorescence-activated cell sorting method |
0.0 |
|
0 |
|
|
67843 |
690 |
BBDR/Rhw |
blood CD4 cell count to CD8 cell count ratio |
specific pathogen-free condition |
Fuller JM, et al., Physiol Genomics. 2009 Apr 7. |
T cell quantity |
not specified |
25 days-30 days |
75 |
median |
340.0 |
% |
|
|
fluorescence-activated cell sorting method |
0.0 |
|
0 |
|
|
67846 |
690 |
BBDR/Rhw |
calculated serum anti-rat type 2 collagen autoantibody titer |
Freund's incomplete adjuvant (50 %) and type II collagen (2 mg/kg) |
Furuya T, et al., Hum Mol Genet 2000 Sep 22;9(15):2241-50 |
blood autoantibody amount |
female |
66 days-126 days |
13 |
|
31.7 |
null |
1.75 |
6.3 |
enzyme linked immunosorbent assay |
0.0 |
|
0 |
|
titer |
69926 |
1241 |
BBDR/Rhw |
blood R73 cell to total mononuclear cell ratio |
specific pathogen-free condition |
Fuller JM, et al., Physiol Genomics. 2009 Apr 7. |
T cell quantity |
not specified |
25 days-30 days |
75 |
median |
60.0 |
% |
|
|
fluorescence-activated cell sorting method |
0.0 |
|
0 |
|
|
67842 |
690 |
BBDR/Rhw |
percentage of study population developing chronic experimental arthritis during a period of time |
Freund's incomplete adjuvant (50 %) (between 1 and 7 days) and type II collagen (2 mg/kg) (between 1 and 7 days) then Freund's incomplete adjuvant (50 %) (between 1 and 35 days) and type II collagen (100 ug) (between 1 and 35 days) |
Furuya T, et al., Hum Mol Genet 2000 Sep 22;9(15):2241-50 |
joint integrity trait |
female |
66 days-126 days |
13 |
|
100.0 |
% |
|
|
in vivo visual assessment |
0.0 |
|
0 |
|
|
69922 |
1241 |
BBDR/Rhw |
percentage of study population developing type 1 diabetes mellitus during a period of time |
anti-RT6.1 antibody (2 ml) (for 28 days) and poly I:C (5 ug/g) (for 28 days) |
Martin AM, et al., Diabetes 1999 Nov;48(11):2138-44 |
glucose metabolism trait |
not specified |
0 days-70 days |
12 |
|
100.0 |
% |
|
|
blood glucose analysis |
0.0 |
injection |
0 |
anti-RT6.1mAB and poly I:C |
|
66147 |
711 |
BBDR/Rhw |
blood CD8 cell count to R73 cell count ratio |
specific pathogen-free condition |
Fuller JM, et al., Physiol Genomics. 2009 Apr 7. |
T cell quantity |
not specified |
25 days-30 days |
75 |
median |
22.0 |
% |
|
|
fluorescence-activated cell sorting method |
0.0 |
|
0 |
|
|
67844 |
690 |
BBDR/Rhw |
percentage of study population developing chronic experimental arthritis during a period of time |
Freund's incomplete adjuvant (50 %) (between 1 and 7 days) and type II collagen (2 mg/kg) (between 1 and 7 days) then Freund's incomplete adjuvant (50 %) (between 1 and 35 days) and type II collagen (100 ug) (between 1 and 35 days) |
Furuya T, et al., Hum Mol Genet 2000 Sep 22;9(15):2241-50 |
joint integrity trait |
male |
66 days-126 days |
11 |
|
100.0 |
% |
|
|
in vivo visual assessment |
0.0 |
|
0 |
|
|
69921 |
1241 |
BBDR/Rhw |
calculated serum anti-rat type 2 collagen autoantibody titer |
Freund's incomplete adjuvant (50 %) and type II collagen (2 mg/kg) |
Furuya T, et al., Hum Mol Genet 2000 Sep 22;9(15):2241-50 |
blood autoantibody amount |
male |
66 days-126 days |
11 |
|
30.6 |
null |
1.51 |
5.0 |
enzyme linked immunosorbent assay |
0.0 |
|
0 |
|
titer |
69925 |
1241 |