Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 1c,Condition 2a,Condition 2b,Condition 2c,Condition 3,Condition 4,Condition 5 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,Kcl-induced blood vessel constriction expressed as percent of force at baseline,,312.35,%,20.21,53.4706,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) ,84680,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),potassium chloride solution (100 mmol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,KCl-induced blood vessel constriction expressed as percent of force at baseline,,301.44,%,27.24,86.1404,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) ,84681,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),potassium chloride solution (100 mmol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,694.94,%,34.53,91.3578,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84672,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,607.58,%,51.55,163.0154,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84673,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,542.39,%,49.85,122.1071,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84674,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,641.52,%,62.37,152.7747,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84675,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,756.89,%,61.56,162.8725,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84676,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,626.89,%,61.39,184.17,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84677,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),phenylephrine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,564.27,%,57.82,141.6295,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84678,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,665.33,%,79.91,178.6842,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84679,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),phenylephrine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.12,0.3175,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84648,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8,,0.09,0.2846,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84649,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.17,0.4164,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84650,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.4,,0.21,0.4696,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84651,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.08,,0.11,0.2694,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84668,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.93,,0.15,0.4743,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84669,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (0-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.37,,0.13,0.3439,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84670,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.24,,0.13,0.3184,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84671,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (0-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.24,%,0.82,2.1695,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67673,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-16.62,%,7.27,17.8078,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84659,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.71,%,0.27,0.6614,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69616,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.53,%,0.41,1.2965,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69617,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.24,%,0.28,0.6859,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69618,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.14,%,0.37,0.9063,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69619,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,94.99,%,0.39,0.8721,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) ,69620,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,64.5,%,15.34,48.5093,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69621,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,91.96,%,2.76,6.7606,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69622,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,92.95,%,1.46,3.5763,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69623,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,70.84,%,4.18,8.36,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84652,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,73.42,%,5.62,14.8691,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84653,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,80.04,%,2.63,5.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84654,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,78.37,%,1.3,2.9069,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84655,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-19.03,%,4.01,9.8225,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) ,84656,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-29.33,%,4.38,13.8508,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84657,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-12.94,%,4.38,11.5884,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84658,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,N/A,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,95.47,%,2.53,,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84662,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-7.1,,0.1,0.2,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84640,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.4,,0.1,0.3162,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84641,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84642,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84643,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.2,,0.1,0.2236,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) ,84644,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.3,,0.2,0.5657,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84645,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.6,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84646,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.7,,0.2,0.4472,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84647,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-6.31,,0.1,0.2,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84664,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.33,,0.25,0.6614,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84665,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.13,0.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84666,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.09,0.2012,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) ,84667,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0.001-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,97.36,%,0.65,1.7197,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67671,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.65,%,1.91,6.04,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67672,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.54,%,0.51,1.2492,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67674,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.76,%,0.68,1.6657,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84660,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.25,%,1.6,5.0596,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84661,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,99.39,%,0.74,1.8126,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84663,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (3.16 umol/l) ,