Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 2a,Condition 2b,Condition 2c,Condition 3a,Condition 3b,Condition 4 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",body mass,,RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0001400,maximum body weight loss to initial body weight ratio,,,,2.2,%,0.7,2.2136,MMO:0000016,body weighing method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107181,arterial catheter implantation (for 1 days),,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",urine sodium amount,,RS:0000785,SR/Hsd,male,49 days,8,,CMO:0000129,urine sodium level,,,,0.3,mmol/l,0.0354,0.1,MMO:0000434,urine sodium analysis,,0.0,,,,,standard diet,102281,standard diet,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",urine sodium amount,,RS:0000785,SR/Hsd,male,77 days,8,,CMO:0000129,urine sodium level,,,,3.8,mmol/l,0.2121,0.6,MMO:0000434,urine sodium analysis,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 28 days),102283,controlled sodium chloride content diet (8 %) (for 28 days),,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",urine sodium amount,,RS:0000785,SR/Hsd,male,91 days,8,,CMO:0000129,urine sodium level,,,,3.1,mmol/l,0.0707,0.2,MMO:0000434,urine sodium analysis,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 42 days),102285,controlled sodium chloride content diet (8 %) (for 42 days),,,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-39,mmHg,3.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67261,controlled sodium content diet (4 %) (for 21 days),,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-21,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67265,controlled sodium content diet (0.15 %) (for 21 days),,ruthenium red (3 mg/kg) ,,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) , 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-31,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) (for 21 days) then ruthenium red (3 mg/kg) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67266,controlled sodium content diet (4 %) (for 21 days),,ruthenium red (3 mg/kg) ,,,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) , 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,7,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) ,67269,controlled sodium content diet (0.15 %) ,,ruthenium red (3 mg/kg) ,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,15,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) ,67270,controlled sodium content diet (4 %) ,,ruthenium red (3 mg/kg) ,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-10,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67273,controlled sodium content diet (0.15 %) ,,apamin (100 ug/kg) ,charybdotoxin (100 ug/kg) ,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-13,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then apamin (100 ug/kg) and charybdotoxin (100 ug/kg) and 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67274,controlled sodium content diet (4 %) ,,apamin (100 ug/kg) ,charybdotoxin (100 ug/kg) ,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-39,mmHg,1.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67235,controlled sodium content diet (4 %) ,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-30,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67237,controlled sodium content diet (0.15 %) ,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-5,mmHg,3.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (0.15 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67239,controlled sodium content diet (0.15 %) ,,ruthenium red (3 mg/kg) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-6,mmHg,2.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,"controlled sodium content diet (4 %) then ruthenium red (3 mg/kg) then 4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",67240,controlled sodium content diet (4 %) ,,ruthenium red (3 mg/kg) ,,,"4-alpha-phorbol 12,13-didecanoate (2.5 mg/kg) ",, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000533,absolute change in mean arterial blood pressure,,,,-28,mmHg,3.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (0.15 %) (for 21 days) then dihydrocapsaicin (30 ug/kg) and pentobarbital (50 mg/kg) ,67243,controlled sodium content diet (0.15 %) (for 21 days),,dihydrocapsaicin (30 ug/kg) ,pentobarbital (50 mg/kg) ,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,106,mmHg,3.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,control condition (0.15 %) ,67233,control condition (0.15 %) ,,,,,,, 731,"Gao F and Wang DH, Hypertension. 2010 Apr;55(4):1018-25. Epub 2010 Mar 1.",arterial blood pressure trait,"DR strain is from Charles River Laboratory, Wilmington, MA",RS:0000785,SR/Hsd,male,56 days to 35 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,110,mmHg,4.0,,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium content diet (4 %) ,67234,controlled sodium content diet (4 %) ,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,49 days,8,,CMO:0000009,mean arterial blood pressure,,,,120,mmHg,1.0607,3.0,MMO:0000031,tail cuff plethysmography,,0.0,,,,,standard diet,102267,standard diet,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,91 days,8,,CMO:0000009,mean arterial blood pressure,,,,114,mmHg,2.1213,6.0,MMO:0000031,tail cuff plethysmography,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 42 days),102269,controlled sodium chloride content diet (8 %) (for 42 days),,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",arterial blood pressure trait,Initial MAP,RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0000009,mean arterial blood pressure,,,,124,mmHg,2.0,6.3246,MMO:0000013,vascular fluid filled catheter,,300.0,5-second intervals,,,,arterial catheter implantation (for 1 days),107335,arterial catheter implantation (for 1 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,105,mmHg,3.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138379,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,107,mmHg,2.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138366,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,110,mmHg,2.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138367,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000009,mean arterial blood pressure,,,,103,mmHg,3.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138378,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",body mass,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000420,body weight gain,,change from surgery weight (2wks),,65,g,4.0,,MMO:0000016,body weighing method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103214,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",body mass,,RS:0000785,SR/Hsd,male,61 days to 52 days,N/A,,CMO:0000420,body weight gain,,change from surgery weight (2wks),,59,g,4.0,,MMO:0000016,body weighing method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138419,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",erythrocyte quantity,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000037,hematocrit,,-,,38,%,2.0,,MMO:0000214,hematocrit analysis,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103230,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",erythrocyte quantity,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000037,hematocrit,,-,,39,%,2.0,,MMO:0000214,hematocrit analysis,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103231,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0000037,hematocrit,,,,42.5,%,0.9,2.846,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0 hours),107239,arterial catheter implantation (for 1 days),,controlled hemorrhage (for 0 hours),,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0000037,hematocrit,,,,30.2,%,1.2,3.7947,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours),107255,arterial catheter implantation (for 1 days),,controlled hemorrhage (for 0.4 hours),,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood chloride amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000059,plasma chloride level,,-,,102,mmol/l,2.0,,MMO:0000451,chloride ion-selective electrode method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103226,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood chloride amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000059,plasma chloride level,,-,,100,mmol/l,3.0,,MMO:0000451,chloride ion-selective electrode method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103227,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood sodium amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000060,plasma sodium level,,-,,145,mmol/l,3.0,,MMO:0000452,sodium ion-selective electrode method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103218,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood sodium amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000060,plasma sodium level,,-,,146,mmol/l,2.0,,MMO:0000452,sodium ion-selective electrode method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103219,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000002,heart rate,,,,437,beats/min,10.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138354,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000002,heart rate,,,,454,beats/min,10.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138355,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,57 days to 49 days,N/A,,CMO:0000002,heart rate,,,,451,beats/min,12.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138375,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,57 days to 49 days,N/A,,CMO:0000002,heart rate,,,,435,beats/min,19.0,,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138374,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",glomerular filtration trait,,RS:0000785,SR/Hsd,male,49 days,8,,CMO:0000765,creatinine clearance,,,,3.5,ml/min,0.0707,0.2,MMO:0000275,urine creatinine analysis,,0.0,,,,,standard diet,102287,standard diet,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",glomerular filtration trait,,RS:0000785,SR/Hsd,male,91 days,8,,CMO:0000765,creatinine clearance,,,,6.1,ml/min,0.2828,0.8,MMO:0000275,urine creatinine analysis,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 42 days),102289,controlled sodium chloride content diet (8 %) (for 42 days),,,,,,, 204,"Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52",blood triglyceride amount,,RS:0000785,SR/Hsd,male,180 days,14,,CMO:0000548,plasma triglyceride level,,,,0.93,mmol/l,0.06,0.2245,MMO:0000234,plasma triglyceride analysis,,,,,,,controlled sodium content diet (0.3 %) then fasting (for 16 hours),11893,controlled sodium content diet (0.3 %) ,,fasting (for 16 hours),,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood potassium amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000061,plasma potassium level,,-,,5.1,mmol/l,0.2,,MMO:0000453,potassium ion-selective electrode method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103222,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",blood potassium amount,,RS:0000785,SR/Hsd,male,56 days to 49 days,N/A,,CMO:0000061,plasma potassium level,,-,,4.8,mmol/l,0.3,,MMO:0000453,potassium ion-selective electrode method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103223,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",body mass,,RS:0000785,SR/Hsd,male,49 days,8,,CMO:0000012,body weight,,,,213,g,2.4042,6.8,MMO:0000016,body weighing method,,0.0,,,,,standard diet,102271,standard diet,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",body mass,,RS:0000785,SR/Hsd,male,91 days,8,,CMO:0000012,body weight,,,,308,g,10.6066,30.0,MMO:0000016,body weighing method,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 42 days),102273,controlled sodium chloride content diet (8 %) (for 42 days),,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",body mass,,RS:0000785,SR/Hsd,male,94 days to 88 days,10,,CMO:0000012,body weight,,,,316,g,8.0,25.2982,MMO:0000016,body weighing method,,0.0,,,,,control condition,107360,control condition,,,,,,, 204,"Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52",body mass,,RS:0000785,SR/Hsd,female,180 days,14,,CMO:0001246,cubic root of body weight to nasoanal length ratio,,,,306,g/mm x 10000,2.0,7.4833,MMO:0000016,body weighing method,,0.0,,,,,controlled sodium content diet (0.3 %) then fasting (for 16 hours),67894,controlled sodium content diet (0.3 %) ,,fasting (for 16 hours),,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0002036,change in heart rate to change in mean arterial blood pressure ratio,,change in heart rate to cchange in heart rate to change in mean arterial blood pressure ratio (CMO:0002036),,-2.13,beats/min/mmHg,0.19,0.4654,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138434,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",eating behavior trait,Food consumed (g) postsurgery per 100 g BW,RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0002214,food intake weight to body weight ratio,,,,7.8,g/d/100g,0.5,1.5811,MMO:0000620,food intake measuring method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107144,arterial catheter implantation (for 1 days),,,,,,, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,139.6,mmol/l,2.1,5.1439,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),102233,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,140.3,mmol/l,1.8,4.4091,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),102234,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,139.3,mmol/l,1.6,3.9192,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),102235,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,140.4,mmol/l,1.4,3.4293,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),102236,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,140.8,mmol/l,1.6,3.9192,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days),102249,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),,sham surgical control condition (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,139.6,mmol/l,1.4,3.4293,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) then surgical denervation (for 21 days),102250,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),,surgical denervation (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,139.8,mmol/l,0.7,1.7146,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days),102251,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),,sham surgical control condition (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood sodium amount,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0000060,plasma sodium level,,,,140.7,mmol/l,0.9,2.2045,MMO:0000039,flame atomic emission spectrometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) then surgical denervation (for 21 days),102252,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),,surgical denervation (for 21 days) 204,"Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52",blood LDL cholesterol amount,,RS:0000785,SR/Hsd,female,180 days,6,,CMO:0001245,calculated plasma low density lipoprotein cholesterol level,,,,14.6718,mg/dl,3.4749,8.5117,MMO:0000284,plasma total cholesterol measurement test,,0.0,,,,,controlled sodium content diet (0.3 %) then fasting (for 16 hours),11890,controlled sodium content diet (0.3 %) ,,fasting (for 16 hours),,,,, 204,"Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52",blood HDL cholesterol amount,,RS:0000785,SR/Hsd,male,180 days,6,,CMO:0000646,plasma high density lipoprotein cholesterol level,,,,27.7992,mg/dl,1.1583,2.8372,MMO:0000282,plasma high-density lipoprotein-cholesterol measurement test,,,,,,,controlled sodium content diet (0.3 %) then fasting (for 16 hours),11892,controlled sodium content diet (0.3 %) ,,fasting (for 16 hours),,,,, 204,"Herrera VL, et al., Circ Res 2004 Mar 5; 94(4):446-52",blood cholesterol amount,,RS:0000785,SR/Hsd,male,180 days,14,,CMO:0000585,plasma total cholesterol level,,,,66.4092,mg/dl,4.6332,17.3358,MMO:0000284,plasma total cholesterol measurement test,,,,,,,controlled sodium content diet (0.3 %) then fasting (for 16 hours),11889,controlled sodium content diet (0.3 %) ,,fasting (for 16 hours),,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",drinking behavior trait,Water consumed (g) postsurgery per 100 g BW,RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0002859,water intake drink rate to body weight ratio,,,,0.76,ml/d/kg,0.09,0.2846,MMO:0000619,drink intake measuring method,,0.0,,arterial catheter implantation,1,days,arterial catheter implantation (for 1 days),107160,arterial catheter implantation (for 1 days),,,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",blood amount,,RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0003663,volume of blood removed to total prehemorrhagic blood volume ratio,5.83 mL/100 g of body weight,volume of blood removed to total prehemorrhagic blood volume ratio (CMO:0003663),,56,%,0.4,1.2649,MMO:0000016,body weighing method,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (for 0.4 hours),109129,arterial catheter implantation (for 1 days),,controlled hemorrhage (for 0.4 hours),,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0003894,mean arterial pressure at the midpoint of a range of renal sympathetic nerve activity,,,,107,mmHg,3.0,7.3485,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138426,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,8,,CMO:0003894,mean arterial pressure at the midpoint of a range of renal sympathetic nerve activity,,,,109,mmHg,3.0,8.4853,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138428,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 3077,"Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.",erythrocyte quantity,"initial hematocrit, final hematocrit, change in hematocrit",RS:0000785,SR/Hsd,male,95 days to 89 days,10,,CMO:0002538,absolute change in hematocrit,,,,11.8,%,0.8,2.5298,MMO:0000215,microhematocrit tube assay with visual assessment,,0.0,,,,,arterial catheter implantation (for 1 days) then controlled hemorrhage (between 0 and 0.4 hours),107271,arterial catheter implantation (for 1 days),,controlled hemorrhage (between 0 and 0.4 hours),,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",urine urotensin II amount,,RS:0000785,SR/Hsd,male,77 days,8,,CMO:0002921,urine urotensin II level to urine creatinine level ratio,,,,181.3,ng/g,29.6631,83.9,MMO:0000073,radioimmunoassay,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 28 days),102279,controlled sodium chloride content diet (8 %) (for 28 days),,,,,,, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,299.6,umol/g,4.5,11.0227,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),102237,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,302.4,umol/g,4.2,10.2879,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),102238,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,301.6,umol/g,3.8,9.3081,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),102239,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,,,301.3,umol/g,4.4,10.7778,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),102240,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),, 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,298.6,umol/g,3.8,9.3081,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days),102257,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),,sham surgical control condition (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,300.6,umol/g,2.8,6.8586,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (0.4 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) then surgical denervation (for 21 days),102258,controlled sodium content diet (0.4 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),,surgical denervation (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,298.7,umol/g,3.2,7.8384,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days) then sham surgical control condition (for 21 days),102259,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,scrambled control oligodeoxynucleotide (4.17 ug/d) (for 21 days),,sham surgical control condition (for 21 days) 2682,"Wainford RD, et al., Hypertension. 2015 Jan;65(1):178-86. doi: 10.1161/HYPERTENSIONAHA.114.04463. Epub 2014 Oct 13.",blood molecular composition trait,,RS:0000785,SR/Hsd,male,119 days to 91 days,6,,CMO:0002923,plasma osmolality,,p osmolality mosm/kg,,300.9,umol/g,3.7,9.0631,MMO:0000170,osmometry,,0.0,,,,,controlled sodium content diet (8 %) (for 21 days) then intracerebroventricular cannula implantation then Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days) then surgical denervation (for 21 days),102260,controlled sodium content diet (8 %) (for 21 days),,intracerebroventricular cannula implantation,,,Gnai2 antisense oligonucleotide (4.17 ug/d) (for 21 days),,surgical denervation (for 21 days) 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,8,,CMO:0003896,range of heart rate variation during variation of mean arterial blood pressure,,change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896),,226,beats/min,17.0,48.0833,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138431,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",heart pumping trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0003896,range of heart rate variation during variation of mean arterial blood pressure,,change in heart rate to change in mean arterial blood pressure ratio (range) (CMO:0003896),,211,beats/min,18.0,44.0908,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138430,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0003897,mean arterial pressure at the midpoint of a range of heart rates,,,,106,mmHg,3.0,7.3485,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138438,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",arterial blood pressure trait,,RS:0000785,SR/Hsd,male,61 days to 52 days,8,,CMO:0003897,mean arterial pressure at the midpoint of a range of heart rates,,,,108,mmHg,3.0,8.4853,MMO:0000011,vascular indwelling catheter method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138439,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",kidney sympathetic nerve activity,,RS:0000785,SR/Hsd,male,61 days to 52 days,8,,CMO:0003892,range of RSNA changes during variation of MAP,,range of ratio of change in renal sympathetic nerve activity (CMO:0003892),,180,%,14.0,39.598,MMO:0000405,implanted wire electrode recording method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),103215,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",kidney sympathetic nerve activity,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0003892,range of RSNA changes during variation of MAP,,range of ratio of change in renal sympathetic nerve activity (CMO:0003892),,185,%,12.0,29.3939,MMO:0000405,implanted wire electrode recording method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138418,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",kidney sympathetic nerve activity,,RS:0000785,SR/Hsd,male,61 days to 52 days,6,,CMO:0003893,change in RSNA to change in MAP ratio,,range of ratio of change in renal sympathetic nerve activity (CMO:0003892),,-2.82,%/mmHg,0.14,0.3429,MMO:0000405,implanted wire electrode recording method,,0.0,,,,,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138422,artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,,, 2801,"Huang BS, et al., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H517-24. doi: 10.1152/ajpheart.00651.2004. Epub 2004 Sep 30.",kidney sympathetic nerve activity,,RS:0000785,SR/Hsd,male,61 days to 52 days,8,,CMO:0003893,change in RSNA to change in MAP ratio,,,,-2.84,%/mmHg,0.12,0.3394,MMO:0000405,implanted wire electrode recording method,,0.0,,,,,aldosterone (22.5 ng/hr) (for 14 days) and artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),138423,aldosterone (22.5 ng/hr) (for 14 days),artificial cerebrospinal fluid with 0.15 M sodium (4.4-4.6 ul/hr) (for 14 days),,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",blood urotensin II amount,,RS:0000785,SR/Hsd,male,49 days,8,,CMO:0003214,plasma urotensin II level,,,,61,pg/ml,2.086,5.9,MMO:0000073,radioimmunoassay,,0.0,,,,,standard diet,102275,standard diet,,,,,,, 2683,"Wu F, et al., Int J Hypertens. 2016;2016:9146870. doi: 10.1155/2016/9146870. Epub 2016 Dec 19.",blood urotensin II amount,,RS:0000785,SR/Hsd,male,91 days,8,,CMO:0003214,plasma urotensin II level,,,,60,pg/ml,2.2627,6.4,MMO:0000073,radioimmunoassay,,0.0,,,,,controlled sodium chloride content diet (8 %) (for 42 days),102277,controlled sodium chloride content diet (8 %) (for 42 days),,,,,,,