Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 2a,Condition 2b,Condition 3a,Condition 3b,Condition 4,Condition 5,Condition 6 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.5517,,0.2461,0.6029,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56000,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.9184,,0.1199,0.268,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56006,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.5086,,0.0741,0.1656,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56016,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,11,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.2075,,0.1491,0.4945,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56028,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.2912,,0.3379,0.8276,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55485,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.6692,,0.1125,0.2757,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55491,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.295,,0.1042,0.2329,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55496,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.0199,,0.0336,0.0751,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55499,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,2,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.5925,,0.1065,0.1506,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),54619,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.76,g/mg,0.1798,0.5685,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),57348,controlled sodium content diet (4 %) (for 21 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,55,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.0305,g/mg,0.0694,0.5146,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),57367,controlled sodium content diet (4 %) (for 21 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.23,g/mg,0.1105,0.3494,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),56984,controlled sodium content diet (4 %) (for 21 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,10,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.361,g/mg,0.1365,0.4315,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),56990,controlled sodium content diet (4 %) (for 21 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,12,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.5617,g/mg,0.1171,0.4057,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),56215,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,8,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.2175,g/mg,0.0907,0.2566,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),56221,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,49,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.0806,g/mg,0.0593,0.415,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),55821,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.51,g/mg,0.0805,0.2416,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),55802,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.942,g/mg,0.0864,0.1932,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),55010,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.726,g/mg,0.1593,0.3561,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),55013,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.9017,g/mg,0.0627,0.1535,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),63166,controlled sodium content diet (4 %) (for 14 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,117,,CMO:0000728,maximum contractile force per wet weight of aorta,,,,1.3081,g/mg,0.0334,0.3612,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours),63177,controlled sodium content diet (4 %) (for 14 days),,potassium ion (80 mmol/l) (for 0.2 hours),phenylephrine (10 umol/l) (for 0.2 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.4528,E-7mole,0.7286,2.304,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56786,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.6256,E-7mole,0.1679,0.3754,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56792,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.995,E-7mole,0.2846,0.6364,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57127,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.8032,E-7mole,0.2784,0.6226,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57130,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.5838,E-7mole,0.2424,0.7664,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56534,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,50,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.3813,E-7mole,0.1123,0.7943,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56553,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,7,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.9222,E-7mole,0.5195,1.3744,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),54589,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,7,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.3843,E-7mole,0.7667,2.0284,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),54595,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.3372,E-7mole,0.2076,0.5872,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55908,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,46,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.6654,E-7mole,0.2087,1.4151,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55927,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.197,E-7mole,0.3749,0.9183,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),63029,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,112,,CMO:0000724,concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,1.312,E-7mole,0.1006,1.0648,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),63038,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.7571,,0.1168,0.3692,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56119,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,54,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.8459,,0.0891,0.6549,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56138,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.3944,,0.0755,0.1688,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56173,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.5624,,0.1222,0.2732,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56176,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.3723,,0.1056,0.3339,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55705,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.4738,,0.1612,0.3949,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55711,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-6.1765,,0.0769,0.2175,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55720,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,8,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-6.2629,,0.0863,0.2442,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55726,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-8.3539,,0.0866,0.2448,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55289,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,50,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-7.8613,,0.0491,0.347,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55308,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-8.1092,,0.1092,0.2676,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),63097,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,119,,CMO:0000722,logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50),,EC50 value is moles/liter,,-8.1504,,0.0304,0.3319,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),63108,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,55.8,%,7.4122,16.5741,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57296,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,61.4,%,3.0757,6.8775,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57299,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,78.3,%,7.5939,24.0141,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56841,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,88.6667,%,2.8944,7.0899,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56847,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,61.5,%,5.7663,16.3095,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57238,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,47,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,71.4894,%,2.9479,20.2096,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57257,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,61.4444,%,6.0533,18.1598,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),54794,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,50,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,71.46,%,3.0298,21.424,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),54813,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,84.8571,%,5.2934,14.0051,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55101,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,85,%,6.1373,16.2378,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55107,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,80.3333,%,8.257,20.2254,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),62629,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,111,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,65.3423,%,1.8444,19.4317,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),62638,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.8599,,0.0629,0.1886,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56929,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,50,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.9339,,0.0405,0.2863,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),56948,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.91,,0.0676,0.1912,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55639,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,47,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.8693,,0.0379,0.2601,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55658,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.1519,,0.1527,0.4828,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55020,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.2728,,0.1254,0.2804,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55026,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.105,,0.1637,0.366,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55369,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.7624,,0.0617,0.1379,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),55372,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,,,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.0863,,0.1858,0.455,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),62852,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 528,PhysGen Vascular data,vasodilation trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,112,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-6.9991,,0.0321,0.3402,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),62861,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.495,,0.307,0.8124,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57403,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.0874,,0.1541,0.4077,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours),57409,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,acetylcholine (0-30 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,56,%,5.5317,12.3693,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),57134,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,40,%,5.058,15.174,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),57146,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,55,%,1.0,1.7321,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),57178,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,41,%,4.5644,13.6931,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),56715,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,10,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,46.3,%,5.6412,17.8391,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),56721,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,42,%,8.544,14.7986,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56728,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,42,%,2.3022,5.1478,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56731,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,11,%,5.5076,9.5394,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),56205,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,14.6,%,1.7493,3.9115,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),56208,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,32.2,%,9.0907,20.3273,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),56271,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,26.1111,%,3.8638,11.5914,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),56283,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,11,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,64.0909,%,4.7126,15.6298,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56333,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,62.1667,%,5.3004,12.9833,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56339,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours), 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,75.5556,%,4.2134,12.6403,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56439,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,10,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,87.3,%,3.8385,12.1386,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours),56445,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,19.6667,%,9.8376,17.0392,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),55989,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,24.6,%,3.6688,8.2037,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),55992,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,26.5556,%,4.9219,14.7658,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),54849,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,10,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,33.6,%,6.4484,20.3917,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),54855,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,11,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,38.7273,%,7.2652,24.096,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),54975,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,33.1667,%,5.606,13.732,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),54981,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,36,%,10.5357,18.2483,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),55055,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,14.4,%,6.3765,14.2583,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),55071,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,9,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,17,%,2.9954,8.9861,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),55083,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,3,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,32.3333,%,13.2958,23.029,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),55143,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,11,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,49.1818,%,6.8924,22.8597,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),55356,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000733,hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,39.8333,%,5.5822,13.6736,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),55362,phenylephrine (1 umol/l) ,,controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours),,controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours),,controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours),, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,99,%,0.6814,1.9272,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56194,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,100,%,0.0,0.0,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56200,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,97.6,%,1.0296,2.3022,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56303,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,11,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,95,%,3.239,10.7424,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56315,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,2,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,100,%,0.0,0.0,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56475,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,99.8,%,0.2,0.4472,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55376,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,98.6,%,0.7483,1.6733,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55379,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,99.375,%,0.4199,1.1877,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55965,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,99.6,%,0.4,0.8944,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55971,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0569,10E-7mol/l,0.0136,0.0304,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56809,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0908,10E-7mol/l,0.0091,0.0203,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56812,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0862,10E-7mol/l,0.0688,0.1685,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56693,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0141,10E-7mol/l,0.0039,0.0088,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56699,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0329,10E-7mol/l,0.0057,0.0128,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56228,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,11,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.1014,10E-7mol/l,0.0377,0.125,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56240,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.2557,10E-7mol/l,0.2005,0.4912,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56260,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0259,10E-7mol/l,0.0082,0.02,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),56266,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,, 522,PhysGen Vascular data,vasodilation trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,2,,CMO:0000726,concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50),,,,0.0263,10E-7mol/l,0.0063,0.0089,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours),55745,phenylephrine (1 umol/l) (for 0.2 hours),,sodium nitroprusside (0-3 umol/l) ,drug dose time series (for 1 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.7388,umol/l,0.121,0.3422,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56876,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,8,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.6332,umol/l,0.1477,0.4177,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),56882,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,8,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0079,umol/l,0.0026,0.0074,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54688,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,50,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0174,umol/l,0.0019,0.0135,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54707,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0239,umol/l,0.0051,0.0163,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54920,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Teklad,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,54,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0508,umol/l,0.0242,0.178,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54939,controlled sodium content diet (4 %) (for 21 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,10,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0523,umol/l,0.0095,0.0302,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54987,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,Moms and pups used in studies were fed Dyets,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,6,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0466,umol/l,0.0158,0.0386,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),54993,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,female,84 days to 70 days,5,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0428,umol/l,0.0071,0.0158,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55124,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 522,PhysGen Vascular data,vasoconstriction trait,"Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks",RS:0000342,FHH/EurMcwi,male,84 days to 70 days,5,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0322,umol/l,0.0092,0.0207,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),55127,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,female,84 days to 70 days,6,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0094,umol/l,0.003,0.0073,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),62774,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,, 528,PhysGen Vascular data,vasoconstriction trait,,RS:0000342,FHH/EurMcwi,male,84 days to 70 days,119,,CMO:0000721,concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50),,,,0.0129,umol/l,0.0014,0.0153,MMO:0000208,wire myography using a Digi-Med tissue force analysis system with force transducer,,,,,,,controlled sodium content diet (4 %) (for 14 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours),62785,controlled sodium content diet (4 %) (for 14 days),,phenylephrine (0-300 umol/l) ,drug dose time series (for 1.2 hours),,,,,