Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 1c,Condition 2a,Condition 2b,Condition 2c,Condition 3,Condition 4,Condition 5 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,97.36,%,0.65,1.7197,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67671,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.65,%,1.91,6.04,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67672,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.24,%,0.82,2.1695,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67673,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.54,%,0.51,1.2492,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,67674,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.71,%,0.27,0.6614,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69616,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,99.53,%,0.41,1.2965,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69617,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.24,%,0.28,0.6859,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69618,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,100.14,%,0.37,0.9063,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (3.16 umol/l) ,69619,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,94.99,%,0.39,0.8721,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (3.16 umol/l) ,69620,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,64.5,%,15.34,48.5093,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69621,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,91.96,%,2.76,6.7606,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69622,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,92.95,%,1.46,3.5763,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (3.16 umol/l) ,69623,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (3.16 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.4,,0.1,0.3162,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84641,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84642,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84643,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.2,,0.1,0.2236,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) ,84644,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.3,,0.2,0.5657,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84645,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.6,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84646,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.7,,0.2,0.4472,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84647,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.12,0.3175,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84648,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8,,0.09,0.2846,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84649,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.9,,0.17,0.4164,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84650,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,sodium nitroprusside (0.316 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.4,,0.21,0.4696,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then sodium nitroprusside (0.316 umol/l) ,84651,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,sodium nitroprusside (0.316 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,70.84,%,4.18,8.36,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84652,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,73.42,%,5.62,14.8691,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84653,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,80.04,%,2.63,5.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84654,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,78.37,%,1.3,2.9069,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (31.6 umol/l) ,84655,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-19.03,%,4.01,9.8225,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (31.6 umol/l) ,84656,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-29.33,%,4.38,13.8508,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84657,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-12.94,%,4.38,11.5884,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84658,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-7.1,,0.1,0.2,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84640,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − ACh response)/(maximum PE response − baseline before PE constriction)] 100,,,-16.62,%,7.27,17.8078,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (31.6 umol/l) ,84659,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (31.6 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,98.76,%,0.68,1.6657,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84660,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,96.25,%,1.6,5.0596,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84661,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,N/A,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,95.47,%,2.53,,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84662,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (3.16 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,[(maximum PE response − SNP response)/(maximum PE response − baseline before PE constriction)] 100,,,99.39,%,0.74,1.8126,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (3.16 umol/l) ,84663,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (3.16 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-6.31,,0.1,0.2,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84664,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.33,,0.25,0.6614,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84665,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.13,0.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84666,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.09,0.2012,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) ,84667,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0.001-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.08,,0.11,0.2694,MMO:0000342,wire myography,aorta,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84668,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.93,,0.15,0.4743,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84669,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (0-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.37,,0.13,0.3439,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84670,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,sodium nitroprusside (0-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-8.24,,0.13,0.3184,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then sodium nitroprusside (0-9.5 umol/l) ,84671,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,sodium nitroprusside (0-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,694.94,%,34.53,91.3578,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84672,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,607.58,%,51.55,163.0154,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84673,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,542.39,%,49.85,122.1071,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (31.6 umol/l) ,84674,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (31.6 umol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,641.52,%,62.37,152.7747,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (31.6 umol/l) ,84675,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,756.89,%,61.56,162.8725,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84676,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,9,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,626.89,%,61.39,184.17,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84677,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),phenylephrine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,564.27,%,57.82,141.6295,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84678,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),,,phenylephrine (31.6 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0002459,phenylephrine-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,phenylephrine-induced blood vessel constriction expressed as percent of force at baseline,,665.33,%,79.91,178.6842,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then phenylephrine (31.6 umol/l) ,84679,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),phenylephrine (31.6 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,Kcl-induced blood vessel constriction expressed as percent of force at baseline,,312.35,%,20.21,53.4706,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then potassium chloride solution (100 mmol/l) ,84680,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),potassium chloride solution (100 mmol/l) ,,,,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasoconstriction trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0002460,potassium chloride-induced blood vessel contractile force expressed as percent of force at baseline,[(response to vasoconstrictor - baseline before constriction)/baseline before constriction] x 100,KCl-induced blood vessel constriction expressed as percent of force at baseline,,301.44,%,27.24,86.1404,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then potassium chloride solution (100 mmol/l) ,84681,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),potassium chloride solution (100 mmol/l) ,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.07,,0.054,0.1429,MMO:0000342,wire myography,,,,,,,vehicle control condition (for 28 days),103586,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.096,,0.04,0.1058,MMO:0000342,wire myography,,,,,,,salidroside (40 mg/kg) (for 28 days),103587,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.29,,0.092,0.2602,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103588,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.3,,0.048,0.127,MMO:0000342,wire myography,,,,,,,salidroside (40 mg/kg) (for 28 days),103589,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,89.88,%,2.56,6.7731,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103590,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,90.64,%,2.0,5.2915,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103591,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,67.1,%,3.32,9.3904,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103592,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,81.86,%,1.905,5.0402,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103593,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.058,,0.048,0.127,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103594,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.038,,0.044,0.1164,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103595,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.96,,0.048,0.1358,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103596,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.21,,0.06,0.1587,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103597,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,97.56,%,1.02,2.6987,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103598,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,98.36,%,0.98,2.5928,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103599,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,94.07,%,1.125,3.182,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103600,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,97.14,%,0.86,2.2753,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103601,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.6,,0.05,0.1323,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103602,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.72,,0.03,0.0794,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103603,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.39,,0.04,0.1131,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103604,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.29,,0.023,0.0609,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103605,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,99.75,%,2.32,6.1381,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103606,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,96.2,%,1.31,3.4659,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103607,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,96.96,%,2.2,6.2225,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103608,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,98.82,%,1.19,3.1484,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103609,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.15,,0.089,0.2355,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103610,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.208,,0.072,0.1905,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103611,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.74,,0.57,1.6122,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103612,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000727,logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-8.35,,0.12,0.3175,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103613,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,96.54,%,1.9,5.0269,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103614,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,90.13,%,1.55,4.1009,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103615,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,86.87,%,3.06,8.655,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103616,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000732,sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,98.78,%,1.82,4.8153,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103617,salidroside (40 mg/kg) (for 28 days),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasodilation trait,,RS:0000731,WKY/NCrl,male,84 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,81.1,%,3.0,9.4868,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109367,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasodilation trait,,RS:0003421,SHR/Bbb,male,84 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,68.1,%,4.3,13.5978,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109368,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasodilation trait,,RS:0000596,MWF/FubRkb,male,84 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,58.9,%,3.7,11.7004,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109369,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasodilation trait,,RS:0002073,MWF-Chr 8SHR/Rkb,male,84 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,83.4,%,7.0,22.1359,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109370,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasodilation trait,,RS:0001373,MWF-Chr 6SHR/Rkb,male,84 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,64,%,3.8,12.0167,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109371,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000731,WKY/NCrl,male,84 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676),,105.7,%,11.0,34.7851,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109377,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000744,SHR/FubRkb,male,84 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676),,147.4,%,18.0,56.921,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109378,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,84 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676),,148.4,%,16.0,50.5964,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109379,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0002073,MWF-Chr 8SHR/Rkb,male,84 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676),,87.2,%,18.0,56.921,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109380,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0001373,MWF-Chr 6SHR/Rkb,male,84 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676),,128.2,%,17.0,53.7587,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109381,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000731,WKY/NCrl,male,84 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677),,7.8,,0.2,0.6325,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109382,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000744,SHR/FubRkb,male,84 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677),,7.6,,0.2,0.6325,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109383,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,84 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677),,8.3,,0.2,0.6325,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109384,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0002073,MWF-Chr 8SHR/Rkb,male,84 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677),,7.7,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109385,control condition (for 0 hours),,,,,,,, 3141,"Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.",vasoconstriction trait,,RS:0001373,MWF-Chr 6SHR/Rkb,male,84 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677),,8.1,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,control condition (for 0 hours),109386,control condition (for 0 hours),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasodilation trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,90.3,%,1.2,3.7947,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,vehicle control condition (for 28 days),109431,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasodilation trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,91.5,%,1.7,5.3759,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,finerenone (10 mg/kg/d) (for 28 days),109432,finerenone (10 mg/kg/d) (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasodilation trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,82.3,%,3.0,9.4868,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,vehicle control condition (for 28 days),109433,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasodilation trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0000731,acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel,,,,89.6,%,1.6,5.0596,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,finerenone (10 mg/kg/d) (for 28 days),109434,finerenone (10 mg/kg/d) (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,,,51.3,%,4.7,14.8627,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),109439,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,,,65.7,%,5.6,17.7088,MMO:0000342,wire myography,,0.0,,,,,finerenone (for 28 days),109440,finerenone (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,,,77.8,%,10.2,32.2552,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),109441,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0003726,norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL,,,,52.9,%,7.9,24.982,MMO:0000342,wire myography,,0.0,,,,,finerenone (for 28 days),109442,finerenone (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,,,6.7,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),109443,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0001011,Crl:WI,male,114 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,,,6.9,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,finerenone (for 28 days),109444,finerenone (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,,,6.9,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),109445,vehicle control condition (for 28 days),,,,,,,, 3140,"Gil-Ortega M, etal., Am J Nephrol. 2020 Feb 21:1-10. doi: 10.1159/000506275.",vasoconstriction trait,,RS:0000596,MWF/FubRkb,male,114 days,10,,CMO:0003727,negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value,,,,6.7,,0.1,0.3162,MMO:0000342,wire myography,,0.0,,,,,finerenone (for 28 days),109446,finerenone (for 28 days),,,,,,,,