Study ID,Study,Experiment Name,Experiment Notes,Strain Ont ID,Strain,Sex,Age,# of Animals,Sample Notes,Clinical Measurement Ont ID,Phenotype,Formula,Clinical Measurement Notes,Average Type,Value,Units,SEM,SD,Method Ont ID,Method,Method Site,Method Duration,Method Notes,Post Insult Type,Post Insult Time Value,Post Insult Time Unit,Conditions,Record ID,Condition 1a,Condition 1b,Condition 1c,Condition 2a,Condition 2b,Condition 2c,Condition 3,Condition 4,Condition 5 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-7.1,,0.1,0.2,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84640,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,10,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.4,,0.1,0.3162,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84641,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84642,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,acetylcholine (0.001-9.5 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-7.2,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84643,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.2,,0.1,0.2236,MMO:0000342,wire myography,mesenteric artery,0.0,BCA assay,,,,controlled carbohydrate content diet (53 %) (for 91 days) and controlled fat content diet (14 %) (for 91 days) and controlled protein content diet (33 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours) then acetylcholine (0.001-9.5 umol/l) ,84644,controlled carbohydrate content diet (53 %) (for 91 days),controlled fat content diet (14 %) (for 91 days),controlled protein content diet (33 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) (for 0.2 hours),acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.3,,0.2,0.5657,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84645,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,6,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.6,,0.1,0.2449,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84646,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (2 umol/l) ,,,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.7,,0.2,0.4472,MMO:0000342,wire myography,mesenteric artery,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (2 umol/l) then NG-nitroarginine methyl ester (100 umol/l) then acetylcholine (0.001-9.5 umol/l) ,84647,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (2 umol/l) ,NG-nitroarginine methyl ester (100 umol/l) ,acetylcholine (0.001-9.5 umol/l) 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,logEC50,,-6.31,,0.1,0.2,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84664,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.33,,0.25,0.6614,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (53 %) (for 63 days) and controlled fat content diet (14 %) (for 63 days) and controlled protein content diet (33 %) (for 63 days) then controlled carbohydrate content diet (69 %) (for 28 days) and controlled fat content diet (12 %) (for 28 days) and controlled protein content diet (19 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84665,controlled carbohydrate content diet (53 %) (for 63 days),controlled fat content diet (14 %) (for 63 days),controlled protein content diet (33 %) (for 63 days),controlled carbohydrate content diet (69 %) (for 28 days),controlled fat content diet (12 %) (for 28 days),controlled protein content diet (19 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0-95 umol/l) , 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,4,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.13,0.26,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 91 days) and controlled fat content diet (12 %) (for 91 days) and controlled protein content diet (19 %) (for 91 days) then phenylephrine (1 umol/l) then acetylcholine (0-95 umol/l) ,84666,controlled carbohydrate content diet (69 %) (for 91 days),controlled fat content diet (12 %) (for 91 days),controlled protein content diet (19 %) (for 91 days),phenylephrine (1 umol/l) ,,,acetylcholine (0-95 umol/l) ,, 735,"Spradley FT, et al., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R150-8. Epub 2011 Oct 26.",vasodilation trait,,RS:0002215,SS/HsdMcwiCrl,male,112 days,5,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),logEC50,,,-6.49,,0.09,0.2012,MMO:0000342,wire myography,aorta,0.0,,,,,controlled carbohydrate content diet (69 %) (for 63 days) and controlled fat content diet (12 %) (for 63 days) and controlled protein content diet (19 %) (for 63 days) then controlled carbohydrate content diet (53 %) (for 28 days) and controlled fat content diet (14 %) (for 28 days) and controlled protein content diet (33 %) (for 28 days) then phenylephrine (1 umol/l) then acetylcholine (0.001-95 umol/l) ,84667,controlled carbohydrate content diet (69 %) (for 63 days),controlled fat content diet (12 %) (for 63 days),controlled protein content diet (19 %) (for 63 days),controlled carbohydrate content diet (53 %) (for 28 days),controlled fat content diet (14 %) (for 28 days),controlled protein content diet (33 %) (for 28 days),phenylephrine (1 umol/l) ,acetylcholine (0.001-95 umol/l) , 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.07,,0.054,0.1429,MMO:0000342,wire myography,,,,,,,vehicle control condition (for 28 days),103586,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.096,,0.04,0.1058,MMO:0000342,wire myography,,,,,,,salidroside (40 mg/kg) (for 28 days),103587,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.29,,0.092,0.2602,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103588,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.3,,0.048,0.127,MMO:0000342,wire myography,,,,,,,salidroside (40 mg/kg) (for 28 days),103589,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.6,,0.05,0.1323,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103602,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0000731,WKY/NCrl,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.72,,0.03,0.0794,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103603,salidroside (40 mg/kg) (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,8,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.39,,0.04,0.1131,MMO:0000342,wire myography,,0.0,,,,,vehicle control condition (for 28 days),103604,vehicle control condition (for 28 days),,,,,,,, 2827,"Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57.",vasodilation trait,,RS:0001299,GK,male,168 days,7,,CMO:0000725,logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50),,,,-7.29,,0.023,0.0609,MMO:0000342,wire myography,,0.0,,,,,salidroside (40 mg/kg) (for 28 days),103605,salidroside (40 mg/kg) (for 28 days),,,,,,,,