TAMOXIFEN PHARMACODYNAMICS PATHWAY (PW:0000839)

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Description

Tamoxifen (TAM, TX), an non-steroidal anti-estrogen, is one of the most commonly used drugs for the treatment and prevention of breast cancer. Estrogen is involved in the growth and development of breast cancers; estrogen mediated transcription is constitutively active in more than 50% of cases. Initially considered an antagonist, TAM is currently classified as a selective estrogen receptor modulator (SERM). It binds competitively to the estrogen receptors (ERs) acting as an antagonist in breast

Pathway Diagram:

Ariadne Genomics Inc. tamoxifen membrane tethered ERs - rapid, non-genomic effects endoxifen 4-OH-TAM breast neoplasms Esr1 Esr2 estrogen signaling pathway supressed target gene expression ---| breast neoplasms tamoxifen pharmacokinetics pathway Ncoa3 --+> Esr1 Esr1 ---> tamoxifen resistance 4-OH-TAM ---- Esr2 endoxifen ---- Esr1 Esr2 ---- tamoxifen Esr1 ---- tamoxifen Ncoa3 mERs ---> tamoxifen resistance mERs endoxifen ---- Esr2 4-OH-TAM ---- Esr1 drug-bound ER corepressors ---| Esr1 tamoxifen resistance tumor growth supressed target gene expression Esr2 ---| supressed target gene expression Esr1 ---- Ncoa3 supressed target gene expression ---| tumor growth Esr1 ---| supressed target gene expression mERs ---- tamoxifen drug-bound ER corepressors ---- Esr1 drug-bound ER corepressors
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Genes in Pathway:

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tamoxifen pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:10402751
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:5130191
RGD:10402751
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:5130191
G Fmo1 flavin containing monooxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:10402751
G Fmo3 flavin containing monooxygenase 3 JBrowse link 13 80,837,418 80,856,214 RGD:10402751
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:5130718
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:5130718
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:5130718
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:5130718
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:10402751

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Moleculeendoxifenendoxifen
Diseasebreast neoplasmsentry point to the cancer disease portal
Small Moleculetamoxifentamoxifen

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the tamoxifen pharmacodynamics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayCyp2b3
aldosterone signaling pathwayNcor1 , Ncor2
altered androgen signaling pathwayNcor2
androgen signaling pathwayNcoa3 , Ncor1 , Ncor2
antipyrine drug pathwayCyp2b3
arachidonic acid metabolic pathwayCyp2b3
artemether pharmacokinetics pathwayCyp3a9
ascorbate and aldarate metabolic pathwayUgt1a5
bisphenol A response pathwayEsr1 , Esr2
carbamazepine pharmacokinetics pathwayCyp2b3 , Cyp3a9
celecoxib pharmacodynamics pathwayCyp2b3 , Cyp2d4
celecoxib pharmacokinetics pathwayCyp2d4
citalopram pharmacodynamics pathwayCyp2d4
citalopram pharmacokinetics pathwayCyp2d4
clomipramine pharmacokinetics pathwayCyp2d4
clopidogrel pharmacodynamics pathwayCyp2b3 , Cyp3a9
clopidogrel pharmacokinetics pathwayCyp2b3 , Cyp3a9
codeine and morphine pharmacodynamics pathwayCyp2d4
codeine and morphine pharmacokinetics pathwayCyp2d4
cortisol signaling pathwayNcoa3 , Ncor1 , Ncor2
cyclophosphamide pharmacodynamics pathwayCyp2b3
cyclophosphamide pharmacokinetics pathwayCyp2b3
desipramine pharmacodynamics pathwayCyp2d4
desipramine pharmacokinetics pathwayCyp2d4
diclofenac pharmacodynamics pathwayCyp2b3
diflunisal pharmacodynamics pathwayCyp2b3
doxepin pharmacokinetics pathwayCyp2d4
estrogen signaling pathwayEsr1 , Esr2 , Ncoa3 , Ncor1 , Ncor2 , Phb2
etodolac pharmacodynamics pathwayCyp2b3
etoposide pharmacodynamics pathwayCyp3a9
etoposide pharmacokinetics pathwayCyp3a9
fenoprofen pharmacodynamics pathwayCyp2b3
fluoxetine pharmacodynamics pathwayCyp2d4 , Cyp3a9
fluoxetine pharmacokinetics pathwayCyp2d4 , Cyp3a9
flurbiprofen pharmacodynamics pathwayCyp2b3
follicle-stimulating hormone signaling pathwayEsr1
forkhead class A signaling pathwayEsr1 , Ncoa3
histamine signaling pathway, immunologicalEsr1
ibuprofen pharmacodynamics pathwayCyp2b3
ifosfamide pharmacodynamics pathwayCyp2b3 , Cyp3a9
ifosfamide pharmacokinetics pathwayCyp2b3 , Cyp3a9
imipramine pharmacodynamics pathwayCyp2d4
imipramine pharmacokinetics pathwayCyp2d4
indometacin pharmacodynamics pathwayCyp2b3
indometacin pharmacodynamics pathwayCyp2b3
insulin-like growth factor signaling pathwayEsr1
irinotecan pharmacodynamics pathwayCyp3a9
irinotecan pharmacokinetics pathwayCyp3a9
ketoprofen pharmacodynamics pathwayCyp2b3
ketorolac pharmacodynamics pathwayCyp2b3
lamivudine pharmacokinetics pathwaySult1a1
leukotriene C4 synthase deficiency pathwayCyp2b3
linoleic acid metabolic pathwayCyp3a9
lornoxicam pharmacodynamics pathwayCyp2b3
luteinizing hormone signaling pathwayEsr1
magnesium salicylate pharmacodynamics pathwayCyp2b3
mefenamic acid pharmacodynamics pathwayCyp2b3
meloxicam pharmacodynamics pathwayCyp2b3
methadone pharmacodynamics pathwayCyp2b3 , Cyp2d4
methadone pharmacokinetics pathwayCyp2b3 , Cyp2d4
mitochondria fusion pathwayPhb2
mycophenolic acid pharmacokinetics pathwayCyp3a9
nabumetone pharmacodynamics pathwayCyp2b3
naproxen pharmacodynamics pathwayCyp2b3
neviparine pharmacokinetics pathwayCyp2b3 , Cyp2d4 , Cyp3a9
nicotine pharmacodynamics pathwayCyp2b3 , Fmo3 , Ugt1a5
nicotine pharmacokinetics pathwayCyp2b3 , Fmo3 , Ugt1a5
Notch signaling pathwayNcor1 , Ncor2
nuclear factor, erythroid 2 like 2 signaling pathwayNcoa3
O-linked glycan biosynthetic pathwayUgt1a5
paracetamol drug pathwayCyp2b3
paracetamol pharmacokinetics pathwayCyp2d4 , Sult1a1
pentose and glucuronate interconversion pathwayUgt1a5
phase I biotransformation pathway via cytochrome P450Cyp2b3 , Cyp2d4 , Cyp3a9 , Fmo1 , Fmo3 , Ugt1a5
phenytoin pharmacodynamics pathwayUgt1a5
piroxicam pharmacodynamics pathwayCyp2b3
porphyrin and chlorophyll metabolic pathwayUgt1a5
prostate cancer pathwayNcor2
retinoic acid signaling pathwayNcoa3 , Ncor1 , Ncor2
retinol metabolic pathwayCyp2b3 , Cyp3a9 , Ugt1a5
salicylic acid pharmacodynamics pathwayCyp2b3
serotonin signaling pathway via receptors engaging G alphas protein familyEsr1
sodium salicylate pharmacodynamics pathwayCyp2b3
sorafenib pharmacokinetics pathwayCyp2b3
starch and sucrose metabolic pathwayUgt1a5
steroid hormone biosynthetic pathwayCyp3a9 , Ugt1a5
sulfite oxidase deficiency pathwaySult1a1
sulfur metabolic pathwaySult1a1
sulindac pharmacodynamics pathwayCyp2b3
tamoxifen pharmacodynamics pathwayCyp2b3 , Cyp2d4 , Cyp3a9 , Esr1 , Esr2 , Fmo1 , Fmo3 , Ncoa3 , Ncor1 , Ncor2 , Phb2 , Sult1a1 , Ugt1a5
tamoxifen pharmacokinetics pathwayCyp2b3 , Cyp2d4 , Cyp3a9 , Esr1 , Fmo1 , Fmo3 , Sult1a1 , Ugt1a5
teniposide pharmacodynamics pathwayCyp3a9
teniposide pharmacokinetics pathwayCyp3a9
tenoxicam pharmacodynamics pathwayCyp2b3
tiaprofenic acid pharmacodynamics pathwayCyp2b3
tolmetin pharmacodynamics pathwayCyp2b3
tramadol pharmacokinetics pathwayCyp2b3 , Cyp2d4
valdecoxib pharmacodynamics pathwayCyp2b3
valproic acid pharmacokinetics pathwayCyp2b3
venlafaxine pharmacokinetics pathwayCyp2d4
vitamin A deficiency pathwayCyp2b3 , Cyp3a9
Phenotype Annotations Associated with Genes in the tamoxifen pharmacodynamics pathway

References Associated with the tamoxifen pharmacodynamics pathway:

Ontology Path Diagram:

paths to the root

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