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Aromatase inhibitors (AI) target the cytochrome P450 aromatase complex, the rate-limiting enzyme of estrogen biosynthesis. Estrogen is essential for female sexual development and reproductive functions and is also important in bone and cardiovascular systems and in brain functions. Estrogen has been implicated in the growth and development of breast cancers; estrogen mediated transcription is constitutively active in more than 50% of cases. Three generation of aromatase inhibitors have been deve

Pathway Diagram:

Ariadne Genomics Inc. AI side effects estrogen signaling pathway estradiol biosynthetic pathway arthralgia osteoporosis breast neoplasms estrogen signaling pathway ---| breast neoplasms aromatase inhibitors ---| Cyp19a1 Cyp19a1 estradiol biosynthetic pathway ---| estrogen signaling pathway Cyp19a1 ---| estradiol biosynthetic pathway estradiol biosynthetic pathway --+> osteoporosis estradiol biosynthetic pathway --+> arthralgia aromatase inhibitors

Genes in Pathway:

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aromatase inhibitor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:5130880

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouparomatase inhibitorsaromatase inhibitors

Pathway Gene Annotations

Disease Annotations Associated with Genes in the aromatase inhibitor pathway
Pathway Annotations Associated with Genes in the aromatase inhibitor pathway

References Associated with the aromatase inhibitor pathway:

Ontology Path Diagram:

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