View Ontology Report


Norepinephrine and epinephrine, whose synthesis and release are prompted by various but distinct stresses, act as neurotransmitters and hormones that signal via various adrenergic receptors, G-protein coupled receptors (GPCR) that couple to distinct G alpha subunits of heterotrimeric G proteins. The beta receptors, for which epinephrine appears to be a favorite agonist, couple to the Gs alpha subunit leading to activation of adenylyl cyclases, cAMP production and subsequent triggering of PKA sig

Pathway Diagram:

Ariadne Genomics Inc. epinephrine prompting stresses epinephrine receptor internalization receptor - G protein uncoupling Gnas G protein mediated signaling pathway via Galphas family beta-arrestin mediated signaling epinephrine biosynthetic pathway protein kinase A (PKA) signaling pathway cAMP --+> protein kinase A (PKA) signaling pathway cAMP G protein mediated signaling pathway via Galphas family --+> cAMP Snx13 ---| Gnas Adrb2 ---- epinephrine Adrb1 ---- epinephrine receptor - G protein uncoupling ---| G protein mediated signaling pathway via Galphas family Grk5 ---| Adrb2 Grk5 ---| Adrb1 Adrbk1 ---| Adrb2 Adrbk1 ---| Adrb1 Grk5 Adrbk1 Snx13 Adrb2 ---- Gnas Adrb1 ---- Gnas Adrb2 ---- Arrb1 Adrb2 ---- Arrb2 Adrb1 ---- Arrb2 Adrb1 ---- Arrb1 Adrb1 Adrb2 Arrb1 Arrb2 Arrb2 ---> beta-arrestin mediated signaling Arrb1 ---> beta-arrestin mediated signaling epinephrine prompting stresses ---> epinephrine epinephrine release

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
epinephrine signaling pathway via adrenergic receptor beta term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:4140391
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:4140391
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5135529
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5135529
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:4140391
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:4140391
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:4140391
G Snx13 sorting nexin 13 JBrowse link 6 54,487,626 54,591,716 RGD:4140388

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculecAMPcyclic AMP

Pathway Gene Annotations

Disease Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Disease TermsGene Symbols
ACTH-Independent Macronodular Adrenal Hyperplasia 1Gnas
ACTH-secreting pituitary adenomaGnas
acute kidney failureAdrb2
adrenal carcinomaGnas
Adrenal Gland NeoplasmsGnas
adrenocortical carcinomaGnas
AIDS Dementia ComplexAdrb2
Albright's hereditary osteodystrophyGnas
allergic contact dermatitisGrk2
Alzheimer's diseaseGnas , Grk5
amphetamine abuseArrb2
Angina PectorisAdrb1 , Adrb2
aortic valve stenosisAdrb1
Arteriovenous FistulaArrb1 , Arrb2
autistic disorderAdrb2
B-Cell Chronic Lymphocytic LeukemiaGnas
Birth WeightAdrb1
breast cancerGnas
Breast NeoplasmsAdrb2 , Gnas
Cafe-au-Lait SpotsGnas
cardiomyopathyAdrb2 , Grk2
cardiovascular system diseaseAdrb1 , Adrb2 , Grk2 , Grk5
cholangiocarcinomaAdrb2 , Gnas
chronic obstructive pulmonary diseaseAdrb1 , Adrb2
Cocaine-Related DisordersGrk2 , Grk5
Colorectal NeoplasmsGnas
Congenital AbnormalitiesGrk2
congestive heart failureAdrb1 , Adrb2 , Arrb1 , Grk2 , Grk5
Coronary DiseaseAdrb2
Cushing syndromeGnas
cystic fibrosisAdrb1 , Adrb2
diabetes mellitusAdrb1
Diabetes Mellitus, Experimental Adrb1
Diabetic NephropathiesGrk2
dilated cardiomyopathyAdrb1 , Adrb2
disease of cellular proliferationGnas
disease of metabolismAdrb2
Embryo LossGrk2
end stage renal failureAdrb2
endocrine system diseaseGnas
endomyocardial fibrosisAdrb1
Experimental ArthritisArrb1 , Arrb2 , Grk2
Experimental Autoimmune MyocarditisGrk2
Experimental Liver CirrhosisAdrb1 , Adrb2 , Arrb2 , Grk2
Experimental Liver NeoplasmsArrb2
familial hyperlipidemiaAdrb2
fatty liver diseaseAdrb2
gastric adenocarcinomaGnas
genetic diseaseGnas
Graves' diseaseAdrb2
growth hormone secreting pituitary adenomaGnas
head and neck squamous cell carcinomaGnas
hemorrhagic diseaseGnas
hepatocellular carcinomaGnas
Hereditary Neoplastic SyndromesAdrb2
human immunodeficiency virus infectious diseaseAdrb2
HyperalgesiaAdrb1 , Grk2
hyperglycemiaAdrb1 , Grk2
Hyperlipoproteinemia Type IIAdrb2
hypertensionAdrb1 , Adrb2 , Arrb2 , Gnas , Grk2 , Grk5
Hypotension, OrthostaticGnas
Insulin ResistanceAdrb2 , Gnas , Grk2
intellectual disabilityGnas
interstitial cystitisAdrb2
kidney diseaseAdrb2
Left Ventricular HypertrophyAdrb1 , Adrb2 , Grk2
Limb IschemiaGrk2
liver cancerGnas
liver cirrhosisArrb1 , Grk2
liver diseaseGrk5
Liver InjuryAdrb2
low tension glaucomaAdrb1
lung adenocarcinomaGnas
lung diseaseAdrb2
major depressive disorderArrb1
McCune Albright syndromeGnas
Metabolic Bone DiseasesGnas
Metabolic SyndromeAdrb2
Multiple AbnormalitiesGnas
myasthenia gravisAdrb2
myocardial infarctionAdrb1 , Adrb2
Myocardial IschemiaAdrb1 , Adrb2
Myocardial Reperfusion InjuryAdrb1 , Adrb2 , Arrb2 , Grk2
Nasal PolypsAdrb2
nervous system diseaseAdrb2
obesityAdrb1 , Adrb2 , Gnas
obstructive lung diseaseGrk5
obstructive sleep apneaAdrb1
open-angle glaucomaAdrb2
Ossification, HeterotopicGnas
pancreatic adenocarcinomaGnas
pancreatic cancerGnas
Parasitic Liver DiseasesGnas
Parkinson's diseaseGrk2 , Grk5
Paroxysmal DyspneaAdrb2
pituitary adenomaGrk2
Pituitary NeoplasmsGnas
pituitary-dependent Cushing's diseaseGnas
pleomorphic xanthoastrocytomaSnx13
polycystic ovary syndromeAdrb2 , Gnas
portal hypertensionArrb2 , Grk2
Precocious PubertyGnas
primary hyperaldosteronismGnas
primary open angle glaucomaAdrb2
Progressive Osseous HeteroplasiaGnas
Prolonged Bleeding Time, Brachydactyly, and Mental RetardationGnas
Prostatic NeoplasmsAdrb2
Pseudohypoparathyroidism Type 1CGnas
pseudohypoparathyroidism type IBGnas
pulmonary edemaAdrb2
renal fibrosisArrb2
renovascular hypertensionAdrb1
Reperfusion InjuryAdrb1 , Adrb2
Respiration DisordersGnas
rheumatoid arthritisGrk2 , Grk5
Right Ventricular HypertrophyGrk2
sciatic neuropathyAdrb2
SepsisAdrb2 , Grk2 , Grk5
sex cord-gonadal stromal tumorGnas
Stomach NeoplasmsAdrb1 , Adrb2
Temporomandibular Joint DisordersGrk5
toxic shock syndromeAdrb2
Transplant RejectionArrb1 , Arrb2
type 1 diabetes mellitusAdrb1
type 2 diabetes mellitusAdrb2 , Arrb2
ulcerative colitisAdrb2
Uterine Cervical NeoplasmsGnas
Vascular System InjuriesGrk2
Ventricular DysfunctionAdrb1
Ventricular Dysfunction, LeftAdrb2
Vestibulocochlear Nerve InjuriesAdrb2
viral encephalitisAdrb2
withdrawal disorderGnas
Pathway Annotations Associated with Genes in the epinephrine signaling pathway via adrenergic receptor beta
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAdrb1
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5
adenosine signaling pathwayGnas
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAdrb1 , Adrb2
amiodarone pharmacodynamics pathwayAdrb1
amlodipine pharmacodynamics pathwayAdrb1
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2 , Grk5
atenolol pharmacodynamics pathwayAdrb1
betaxolol pharmacodynamics pathwayAdrb1
bile acid transport pathwayGnas
bisoprolol pharmacodynamics pathwayAdrb1
bupranolol drug pathwayAdrb1
bupranolol pharmacodynamics pathwayAdrb1
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2
calcium/calcium-mediated signaling pathwayAdrb1 , Adrb2 , Gnas
carvedilol pharmacodynamics pathwayAdrb1
Chagas disease pathwayGnas
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk5
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Gnas
dilated cardiomyopathy pathwayAdrb1 , Gnas
diltiazem pharmacodynamics pathwayAdrb1
disopyramide pharmacodynamics pathwayAdrb1
dobutamine pharmacodynamics pathwayAdrb1
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Gnas , Grk2 , Grk5
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk5
eicosanoid signaling pathwayArrb2 , Grk2
endocytosis pathwayAdrb1 , Adrb2 , Arrb1 , Arrb2 , Grk2 , Grk5
Entamoebiasis pathwayGnas
epinephrine signaling pathway via adrenergic receptor betaAdrb1 , Adrb2 , Arrb1 , Arrb2 , Gnas , Grk2 , Grk5 , Snx13
esmolol pharmacodynamics pathwayAdrb1
flecainde pharmacodynamics pathwayAdrb1
follicle-stimulating hormone signaling pathwayGnas
fosphenytoin pharmacodynamics pathwayAdrb1
G protein mediated signaling pathwayGrk2
G protein mediated signaling pathway via Galphai familyAdrb2
G protein mediated signaling pathway via Galphas familyAdrb1 , Adrb2 , Gnas , Grk2 , Snx13
glucagon signaling pathwayGnas
glutamate signaling pathwayGnas , Grk2
gonadotropin-releasing hormone signaling pathwayGnas
Hedgehog signaling pathwayArrb2 , Grk2
histamine signaling pathway, immunologicalGnas
ibutilide pharmacodynamics pathwayAdrb1
isoprenaline pharmacodynamics pathwayAdrb1
isradipine pharmacodynamics pathwayAdrb1
kinin signaling pathwayArrb1 , Arrb2
levobunolol pharmacodynamics pathwayAdrb1
lidocaine pharmacodynamics pathwayAdrb1
long term depressionGnas
luteinizing hormone signaling pathwayGnas
melanocortin system pathwayGnas
metoprolol pharmacodynamics pathwayAdrb1
mexiletine pharmacodynamics pathwayAdrb1
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
nadolol pharmacodynamics pathwayAdrb1
nebivolol pharmacodynamics pathwayAdrb1
nifedipine pharmacodynamics pathwayAdrb1
nimodipine pharmacodynamics pathwayAdrb1
nisoldipine pharmacodynamics pathwayAdrb1
nitrendipine pharmacodynamics pathwayAdrb1
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAdrb1
phenytoin pharmacodynamics pathwayAdrb1
pindolol pharmacodynamics pathwayAdrb1
procainamide pharmacodynamics pathwayAdrb1
propranolol pharmacodynamics pathwayAdrb1
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
quinidine pharmacodynamics pathwayAdrb1
Rho/Rac/Cdc42 mediated signaling pathwayAdrb1
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
somatostatin signaling pathwayGrk2
sotalol pharmacodynamics pathwayAdrb1
timolol pharmacodynamics pathwayAdrb1
transforming growth factor-beta Smad dependent signaling pathwayArrb2
vasopressin signaling pathwayGnas
vasopressin signaling pathway via receptor type 2Gnas
verapamil pharmacodynamics pathwayAdrb1
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2

References Associated with the epinephrine signaling pathway via adrenergic receptor beta:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: