ALTERED ANDROGEN SIGNALING PATHWAY (PW:0000784)

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Description

The androgen signaling pathway plays important roles in the development and maintenance of male phenotype and reproductive functions and in a range of other processes in nonreproductive tissues. Up-regulation of the pathway, primarily at the level of the receptor, has been associated with the development and progression of prostate cancer. Prostate neoplasm is a common form of cancer affecting about 1 in 5 men. Normal as well as malignant prostate tissues rely on the action of androgen hormones

Pathway Diagram:

Elsevier Inc. DHT testosterone Ncoa2 Ncor2 Ar target genes Prostatic Neoplasms Ar target genes ---> prostate cancer pathway Ar chaperones non-steroid Ar antagonist Ar corepressors ---> Translocated Ar complex Ar coactivators Ar corepressors Ar ---- Ar antagonist Ar ---- non-steroid Ar Ar mutations Ar amplification Ar ---- Ar chaperones increased expression of steroidogenic genes ---> testosterone biosynthetic pathway testosterone reduction ---> testosterone biosynthetic pathway testosterone reduction Translocated Ar complex ---> Ar target genes Ar target genes ---> Prostatic Neoplasms Ar ---- DHT increased expression of steroidogenic genes Ar corepressors ---- Translocated Ar complex Ar coactivators ---- Translocated Ar complex Ar coactivators ---> Translocated Ar complex Ar ---> Translocated Ar complex Ar ---- testosterone testosterone biosynthetic pathway gene fusion events prostate cancer pathway gene fusion events ---> prostate cancer pathway gene fusion events ---> Prostatic Neoplasms Translocated Ar complex
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Genes in Pathway:

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altered androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaytestosterone biosynthetic pathway
Pathwayprostate cancer pathway
Small MoleculeDHTdihydrotestosterone
DiseaseProstatic Neoplasmsentry point to the cancer disease portal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered androgen signaling pathway
Disease TermsGene Symbols
acute kidney failureAr
acute myeloid leukemiaNcoa2
alopeciaAr
androgen insensitivity syndromeAr
Androgen Insensitivity Syndrome due to Coactivator DeficiencyAr
astrocytomaAr
attention deficit hyperactivity disorderAr
autistic disorderAr
breast cancerNcor2
Breast NeoplasmsAr , Ncoa2
Castration-Resistant Prostatic NeoplasmsAr
conduct disorderAr
coronary artery diseaseAr
cryptorchidismAr
Denys-Drash syndromeAr
Diabetes Mellitus, Experimental Ar
ductal carcinoma in situAr
endometrial cancerAr
endometrial carcinomaNcor2
endometriosisAr
Experimental Liver CirrhosisNcor2
Fabry diseaseAr
Familial Prostate CancerAr
Female InfertilityAr
genetic diseaseAr
gestational diabetesAr
Gynecomastia, FamilialAr
hepatocellular carcinomaAr
hypertensionAr
hypogonadismAr
hypospadiasAr
Hypospadias 1, X-LinkedAr
Insulin ResistanceAr
invasive ductal carcinomaAr
Kennedy's diseaseAr
Knee OsteoarthritisAr
leiomyomaAr
leukemiaAr
Lubs SyndromeAr
Male Breast NeoplasmsAr
male infertilityAr
male reproductive system diseaseAr
Mammary Neoplasms, ExperimentalAr
Mullerian AplasiaAr
myelofibrosisNcor2
Neoplasm Recurrence, LocalAr
obesityAr
oppositional defiant disorderAr
osteoarthritisNcor2
osteoporosisAr
Osteoporotic FracturesAr
polycystic ovary syndromeAr
Postmenopausal OsteoporosisAr
Pregnancy ComplicationsNcoa2
prostate adenocarcinomaAr
prostate cancerAr , Ncoa2
Prostate Cancer, SomaticAr
prostate carcinoma in situAr
prostatic hypertrophyAr
Prostatic NeoplasmsAr , Ncoa2 , Ncor2
SarcopeniaAr
spinal muscular atrophyAr
type 2 diabetes mellitusAr
Pathway Annotations Associated with Genes in the altered androgen signaling pathway
Phenotype Annotations Associated with Genes in the altered androgen signaling pathway

References Associated with the altered androgen signaling pathway:

Ontology Path Diagram:

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