ESTRADIOL BIOSYNTHETIC PATHWAY (PW:0000781)

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Description

Estrogen hormones are responsible for the development and maintenance of female phenotype and reproductive functions and a range of other processes in nonreproductive tissues. Estradiol, the main C18 estrogen, is primarily synthesized in the ovaries. Like all steroid hormones, estrogens are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression of steroidogen

Pathway Diagram:

Ariadne Genomics Inc. Por e Sts Sult1e1 Hsd17b1 Hsd3b2 Hsd3b1 Sts. Sult2a1 Cyp17a1 e(3) Cyp11a1 Fdx1 Fdxr cholesterol androstenediol ---> testosterone NADPH(3) ---> e(3) NADP+(3) NADPH(3) androstenediol DHEA ---> androstenedione Star NADP+ NADPH Por ---> Cyp17a1 Por ---> Cyp19a1 androstenedione testosterone NADPH(3) ---> NADP+(3) NADPH ---> e estradiol pregnenolone cholesterol ---> pregnenolone DHEA ---> DHEAS androstenedione ---> estrone testosterone ---> androstenedione estradiol ---> estrone NADPH ---> NADP+ 17-hydroxypregnenolone pregnenolone ---> 17-hydroxypregnenolone 17-hydroxypregnenolone ---> DHEA Cyp19a1 estrone ---> estrone-S estrone estrone-S ---> estrone DHEAS DHEA DHEAS ---> DHEA estrone-S Hsd17b2 estrone ---> estradiol Hsd17b3 DHEA ---> androstenediol androstenedione ---> testosterone testosterone ---> estradiol
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Genes in Pathway:

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estradiol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:4889549
RGD:2325883
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the estradiol biosynthetic pathway
Disease TermsGene Symbols
17,20-Lyase Deficiency, IsolatedCyp17a1
17-Hydroxysteroid Dehydrogenase DeficiencyHsd17b3
46, XY Disorders of Sex DevelopmentCyp11a1
Abortion, SpontaneousHsd17b1
adenocarcinomaCyp19a1
Adrenal Hyperplasia 2Hsd3b2
Adrenal Hyperplasia, Congenital, Type 5Cyp17a1
Adrenal InsufficiencyCyp11a1
alcoholic hepatitisSts , Sult1e1
Alzheimer's diseaseCyp19a1 , Hsd17b3 , Hsd3b1
amenorrheaCyp17a1 , Cyp19a1 , Por
Antley-Bixler syndromePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISPor
aromatase excess syndromeCyp19a1
attention deficit hyperactivity disorderSts
AUDITORY NEUROPATHY AND OPTIC ATROPHYFdxr
autistic disorderCyp19a1
bladder neck obstructionCyp19a1
bone resorption diseaseCyp19a1
Brain InjuriesCyp11a1
Breast NeoplasmsCyp17a1 , Cyp19a1 , Hsd17b1 , Sult1e1
CardiomegalyCyp11a1 , Star
Cell Transformation, NeoplasticPor
Chemical and Drug Induced Liver InjurySult1e1
cholelithiasisCyp17a1
congenital adrenal hyperplasiaCyp11a1 , Cyp17a1 , Hsd3b2 , Por , Star
congenital adrenal insufficiencyCyp11a1
Critical IllnessCyp19a1
cryptorchidismHsd3b2 , Sts
Cutaneous Malignant Melanoma, Susceptibility To, 1Cyp17a1
Diabetic NephropathiesCyp19a1
Endometrial NeoplasmsCyp11a1 , Cyp19a1 , Hsd17b2 , Star , Sult1e1
endometriosisCyp19a1 , Hsd17b1 , Hsd17b2
EpendymomaHsd3b2
Esophageal NeoplasmsCyp19a1
Experimental Diabetes MellitusCyp11a1 , Cyp19a1 , Star , Sts
Experimental Liver CirrhosisCyp17a1 , Hsd17b2 , Sult1e1 , Sult2a1
fatty liver diseaseCyp19a1 , Sts
Female InfertilityCyp17a1 , Cyp19a1
Fetal Growth RetardationCyp11a1 , Star
FeverStar
FibrosisCyp19a1
Gallbladder NeoplasmsCyp17a1
genetic diseaseFdxr , Hsd17b3 , Sts
gestational diabetesCyp19a1
gliosarcomaPor
Gonadal Dysgenesis, XX Type, with DeafnessCyp17a1
hepatocellular carcinomaCyp17a1 , Hsd3b2
hyperglycemiaCyp11a1
HyperkalemiaCyp17a1
hyperprolactinemiaHsd3b1 , Hsd3b2
hypertensionCyp11a1 , Cyp19a1 , Hsd3b1 , Hsd3b2 , Sts
hypogonadismCyp11a1 , Cyp17a1 , Cyp19a1 , Hsd3b1 , Star
hypopituitarismCyp17a1 , Cyp19a1
hypospadiasHsd3b1 , Hsd3b2
HypotensionPor
hypothyroidismCyp19a1 , Hsd3b1 , Star
InflammationSts
Insulin ResistanceSts
Kidney Reperfusion InjuryCyp19a1
learning disabilityPor
Lipoid Congenital Adrenal HyperplasiaCyp11a1 , Star
liver diseaseSult1e1
male infertilityCyp17a1
malignant hypertensionCyp17a1
melanomaCyp17a1
Musculoskeletal AbnormalitiesPor
Neoplasm MetastasisCyp19a1 , Sult1e1
nephrosisCyp11a1 , Star
neural tube defectPor
NeuralgiaCyp17a1
nonalcoholic fatty liver diseaseCyp17a1
obesitySts
OligomenorrheaCyp17a1
osteoporosisCyp17a1 , Cyp19a1
Osteoporosis, PostmenopausalCyp19a1
ovarian cystCyp17a1
ovarian diseaseCyp19a1
Ovarian NeoplasmsCyp19a1
pancreatic cancerCyp17a1
pancreatitisFdx1
Paranoid DisordersHsd3b2
placental insufficiencyCyp19a1
pleomorphic xanthoastrocytomaPor
polycystic ovary syndromeCyp17a1 , Cyp19a1 , Hsd3b1 , Hsd3b2 , Star
prostate carcinoma in situCyp19a1
Prostatic NeoplasmsCyp17a1 , Cyp19a1 , Hsd17b1 , Hsd17b3 , Hsd3b1 , Hsd3b2 , Sult1e1 , Sult2a1
prostatitisCyp19a1
protein-energy malnutritionCyp19a1
pseudohermaphroditismHsd17b3
RecurrenceCyp19a1
Reperfusion InjuryCyp19a1 , Sult1e1
rheumatoid arthritisSts
schizophreniaSts
sciatic neuropathyCyp11a1 , Cyp17a1 , Hsd3b1
sex differentiation diseaseHsd17b3
sexual disorderCyp17a1
Sexual InfantilismCyp19a1
Sjogren's syndromeCyp19a1
Smith-Magenis syndromeFdxr , Hsd17b1
status epilepticusCyp11a1
Tissue AdhesionsCyp19a1
Toe Syndactyly, Telecanthus, and Anogenital and Renal MalformationsStar
type 2 diabetes mellitusCyp11a1 , Hsd17b3 , Hsd3b1 , Star
urethral obstructionCyp19a1
urinary bladder cancerCyp19a1 , Por
visual epilepsyCyp11a1
Weight GainSts
X-linked ichthyosisSts
Pathway Annotations Associated with Genes in the estradiol biosynthetic pathway

References Associated with the estradiol biosynthetic pathway:

Ontology Path Diagram:

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