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Estrogen hormones are responsible for the development and maintenance of female phenotype and reproductive functions and a range of other processes in nonreproductive tissues. Estradiol, the main C18 estrogen, is primarily synthesized in the ovaries. Like all steroid hormones, estrogens are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the change in the expression of steroidogen

Pathway Diagram:

Ariadne Genomics Inc. Por e Sts Sult1e1 Hsd17b1 Hsd3b2 Hsd3b1 Sts. Sult2a1 Cyp17a1 e(3) Cyp11a1 Fdx1 Fdxr cholesterol androstenediol ---> testosterone NADPH(3) ---> e(3) NADP+(3) NADPH(3) androstenediol DHEA ---> androstenedione Star NADP+ NADPH Por ---> Cyp17a1 Por ---> Cyp19a1 androstenedione testosterone NADPH(3) ---> NADP+(3) NADPH ---> e estradiol pregnenolone cholesterol ---> pregnenolone DHEA ---> DHEAS androstenedione ---> estrone testosterone ---> androstenedione estradiol ---> estrone NADPH ---> NADP+ 17-hydroxypregnenolone pregnenolone ---> 17-hydroxypregnenolone 17-hydroxypregnenolone ---> DHEA Cyp19a1 estrone ---> estrone-S estrone estrone-S ---> estrone DHEAS DHEA DHEAS ---> DHEA estrone-S Hsd17b2 estrone ---> estradiol Hsd17b3 DHEA ---> androstenediol androstenedione ---> testosterone testosterone ---> estradiol

Genes in Pathway:

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estradiol biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:4892309
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 JBrowse link 10 88,987,558 88,989,758 RGD:4889549
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the estradiol biosynthetic pathway

References Associated with the estradiol biosynthetic pathway:

Ontology Path Diagram:

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