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Androgen hormones are responsible for the development and maintenance of male phenotype and reproductive functions and a range of other processes in nonreproductive tissues. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. Like all steroid hormones, androgens are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis

Pathway Diagram:

Ariadne Genomics Inc. Srd5a1 Srd5a2 Hsd17b2 Sts Sult2a1 e Cyp17a1 Por Fdx1 Fdxr e(3) Cyp11a1 cholesterol 17-hydroxypregnenolone ---> DHEA DHEA ---> DHEAS DHEAS ---> DHEA DHEA DHEAS DHEA ---> androstenediol Hsd17b3 NADP+ NADPH(3) ---> e(3) NADP+(3) NADPH(3) Star NADPH NADPH ---> e pregnenolone ---> 17-hydroxypregnenolone cholesterol ---> pregnenolone 17-hydroxypregnenolone androstenediol pregnenolone NADPH ---> NADP+ NADPH(3) ---> NADP+(3) Hsd3b2 Hsd3b1 testosterone ---> dihydrotestosterone DHEA ---> androstenedione androstenediol ---> testosterone testosterone androstenedione testosterone ---> androstenedione androstenedione ---> testosterone dihydrotestosterone

Genes in Pathway:

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testosterone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:2325883
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:2325883
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:4889549
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:2325883
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889549
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:4889549
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2325883
G Srd5a1 steroid 5 alpha-reductase 1 JBrowse link 1 36,320,504 36,354,694 RGD:2325883
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:2325883
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6893583
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:2325883

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeDHEAdehydroepiandrosterone

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the testosterone biosynthetic pathway

References Associated with the testosterone biosynthetic pathway:

Ontology Path Diagram:

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Import into Pathway Studio: