ALDOSTERONE BIOSYNTHETIC PATHWAY (PW:0000773)

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Description

Mineralocorticoid hormones are responsible for controlling the reabsorption of inorganic ions (Na+, Cl- and HCO3-) by the kidney. Aldosterone, the main C21 mineralocorticoid, is primarily synthesized in the cortex of the adrenal gland. Like all steroid hormones, mineralocorticoids are derived from cholesterol; their biosynthesis is tightly regulated by the hypothalamus-pituitary-gonadal axis. The chronic steroidogenic response involves the

Pathway Diagram:

Ariadne Genomics Inc. e(3) Por Fdx1 Cyp11a1 e Star cholesterol ---> pregnenolone cholesterol Cyp21a1 Hsd3b2 Hsd3b1 pregnenolone ---> progesterone progesterone progesterone ---> desoxycorticosterone desoxycorticosterone NADPH NADPH ---> e NADP+ NADPH ---> NADP+ corticosterone aldosterone Fdxr NADPH(3) NADP+(3) NADPH(3) ---> e(3) NADPH(3) ---> NADP+(3) Fdx1 ---> Cyp11a1 Cyp11b1 Fdx1 ---> Cyp11b1 Cyp11b2 Fdx1 ---> Cyp11b2 desoxycorticosterone ---> corticosterone corticosterone ---> aldosterone pregnenolone
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Genes in Pathway:

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aldosterone biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4892309
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889549
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:4889549
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:4889549
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:2325883
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:2325883
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:4892309
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:2325883

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the aldosterone biosynthetic pathway
Phenotype Annotations Associated with Genes in the aldosterone biosynthetic pathway

References Associated with the aldosterone biosynthetic pathway:

Ontology Path Diagram:

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