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Statins are a class of drugs that act as competitive inhibitors of HMG-CoA reductase, the enzyme that catalyzes the formation of mevalonate from HMG-COA in the rate-determining step of the cholesterol biosynthetic pathway. Currently, there are 6 statins available in the United States atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. Lovastatin, pravastatin and simvastatin are fungus-derived; atorvastatin, fluvastatin and rosuvastatin are synthetic. Statins have

Pathway Diagram:

Ariadne Genomics Inc. Abcb11 ABCC2 ABCB1 ABCG2 UGT1A3 UGT1A1 CYP2D6 CYP2C9 CYP2C8 CYP3A4 SLCO2B1 SLCO1B1 SLCO1B3 uptaken statins UGT1A1 ---> statin metabolites CYP2D6 ---> statin metabolites CYP3A4 ---> statin metabolites UGT1A3 ---> statin metabolites CYP2C9 ---> statin metabolites statins ---> uptaken statins statin metabolites ---> statins and metabolites elimination statins and metabolites elimination statins CYP2C8 ---> statin metabolites statin metabolites

Genes in Pathway:

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statin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:1598579

Pathway Gene Annotations

Disease Annotations Associated with Genes in the statin pharmacokinetics pathway
Pathway Annotations Associated with Genes in the statin pharmacokinetics pathway

References Associated with the statin pharmacokinetics pathway:

Ontology Path Diagram:

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