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Statins are a class of drugs that act as competitive inhibitors of HMG-CoA reductase, the enzyme that catalyzes the formation of mevalonate from HMG-COA in the rate-determining step of the cholesterol biosynthetic pathway. Currently, there are 6 statins available in the United States atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. Lovastatin, pravastatin and simvastatin are fungus-derived; atorvastatin, fluvastatin and rosuvastatin are synthetic. Statins have

Pathway Diagram:

Ariadne Genomics Inc. Abcb11 ABCC2 ABCB1 ABCG2 UGT1A3 UGT1A1 CYP2D6 CYP2C9 CYP2C8 CYP3A4 SLCO2B1 SLCO1B1 SLCO1B3 uptaken statins UGT1A1 ---> statin metabolites CYP2D6 ---> statin metabolites CYP3A4 ---> statin metabolites UGT1A3 ---> statin metabolites CYP2C9 ---> statin metabolites statins ---> uptaken statins statin metabolites ---> statins and metabolites elimination statins and metabolites elimination statins CYP2C8 ---> statin metabolites statin metabolites

Genes in Pathway:

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statin pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:1598579

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the statin pharmacokinetics pathway

References Associated with the statin pharmacokinetics pathway:

Ontology Path Diagram:

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