P53 SIGNALING PATHWAY (PW:0000718)

View Ontology Report

Description

The p53 tumor suppression transcription factor, many times referred to as the 'guardian of the genome' or as the 'cellular gatekeeper', is at the hub of many signaling and regulatory networks. It represents a critical node of cellular homeostasis integrating many cues emerging from exogenous and endogenous stresses and in response promoting, as necessary, cell cycle arrest, apoptosis or senescence, among others. A key signal activating the p53 pathway is DNA damage, such as double-strand breaks

Pathway Diagram:

Elsevier Inc. Mdm2 ---| Tp53 Mdm2 ---- Tp53 Tp53 ---> Mdm2 Mdm4 ---- Tp53 Mdm4 p53, Mdm2 acetylation ---> Tp53 p53 methylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway --+> Tp53 Tp53 <--> non-coding RNAs - p53 targets, regulators, effectors non-coding RNAs - p53 targets, regulators, effectors RNA polymerase II transcription initiation pathway Tp53 --+> RNA polymerase II transcription pathway p53 targets Tp53 --+> intrinsic apoptotic pathway Tp53 --+> cell cycle arrest Tp53 --+> senescence Tp53 ---> p53 targets Tp53 ---> non-coding RNAs - p53 targets, regulators, effectors p53-dependent histone acetylation RNA polymerase II transcription pathway p53-dependent histone acetylation ---- Tp53 Tp53 exogenous stress NO p53 binding partners p53 regulators p53, Mdm2 acetylation ---| Mdm2 p53, Mdm2 phosphorylation ---> Mdm2 p53, Mdm2 phosphorylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway ---> p53, Mdm2 phosphorylation p53, Mdm2 acetylation p53 methylation p53, Mdm2 phosphorylation intrinsic apoptotic pathway cell cycle arrest endogenous stress ataxia telangiectasia-mutated (ATM) signaling pathway Mdm4 ---| Tp53 exogenous stress --+> Tp53 p53 ubiquitination Mdm2 p53 binding partners ---- Tp53 Mdm2 ---- Mdm4 senescence endogenous stress --+> Tp53
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Genes in Pathway:

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p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:6484113
RGD:8662965
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:6907045
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6907045
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6907045
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6907045
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:8662965
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6484113
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6907045
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6907045
G Ccnb3 cyclin B3 JBrowse link X 16,300,752 16,402,206 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6907045
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6907045
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6907045
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:6484113
RGD:6907045
G Ccng2 cyclin G2 JBrowse link 14 16,267,572 16,276,068 RGD:6907045
G Cd82 Cd82 molecule JBrowse link 3 82,324,344 82,368,846 RGD:6907045
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6907045
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6484113
RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Cop1 COP1, E3 ubiquitin ligase JBrowse link 13 76,942,883 77,076,015 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2316155
RGD:8662965
RGD:6484113
G Cse1l chromosome segregation 1 like JBrowse link 3 163,664,074 163,702,074 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6484113
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:6484113
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:6484113
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:6484113
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 7 11,944,957 11,963,268 RGD:6484113
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 48,831,209 48,913,341 RGD:6484113
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6484113
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 7 61,785,423 61,816,775 RGD:6484113
G E4f1 E4F transcription factor 1 JBrowse link 10 13,812,335 13,835,847 RGD:6484113
G Ei24 EI24, autophagy associated transmembrane protein JBrowse link 8 39,254,883 39,271,238 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6484113
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6907045
G Fbxo11 F-box protein 11 JBrowse link 6 11,662,356 11,737,427 RGD:6484113
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6907045
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6907045
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Gtse1 G-2 and S-phase expressed 1 JBrowse link 7 126,736,416 126,753,221 RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:2316155
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:6484113
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6907045
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:8662965
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:8662965
G Kat5 lysine acetyltransferase 5 JBrowse link 1 220,967,795 220,974,596 RGD:2316155
RGD:8662965
RGD:6484113
G Kat8 lysine acetyltransferase 8 JBrowse link 1 199,360,645 199,372,925 RGD:2316155
RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6484113
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Mdm4 MDM4, p53 regulator JBrowse link 13 49,786,776 49,828,780 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:8662965
G Nedd8 neural precursor cell expressed, developmentally down-regulated 8 JBrowse link 15 34,340,607 34,352,673 RGD:6484113
G Perp PERP, TP53 apoptosis effector JBrowse link 1 14,224,392 14,236,838 RGD:6907045
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:6484113
RGD:8662965
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6907045
G Pou4f1 POU class 4 homeobox 1 JBrowse link 15 88,618,255 88,622,712 RGD:8662965
G Pou4f2 POU class 4 homeobox 2 JBrowse link 19 33,160,180 33,163,821 RGD:8662965
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:6484113
RGD:6907045
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B JBrowse link 6 136,397,658 136,469,757 RGD:8662965
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like JBrowse link 1 80,271,288 80,290,946 RGD:6484113
RGD:8662965
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prmt5 protein arginine methyltransferase 5 JBrowse link 15 33,156,508 33,165,893 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6907045
G Ptpa protein phosphatase 2 phosphatase activator JBrowse link 3 8,982,122 9,012,585 RGD:6484113
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6484113
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 14 17,615,968 17,631,715 RGD:2316155
RGD:6907045
RGD:6484113
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:6484113
G Rpl23 ribosomal protein L23 JBrowse link 10 85,721,398 85,725,359 RGD:6484113
G Rpl5l1 ribosomal protein L5-like 1 JBrowse link 10 112,564,193 112,565,170 RGD:6484113
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link 3 39,595,301 39,596,718 RGD:6907045
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:6907045
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 7 76,750,045 76,780,817 RGD:6907045
G Serpinb5 serpin family B member 5 JBrowse link 13 26,903,052 26,923,250 RGD:6907045
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6907045
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:6907045
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:6907045
G Setd7 SET domain containing 7, histone lysine methyltransferase JBrowse link 2 140,576,188 140,618,405 RGD:2316155
RGD:6484113
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6907045
G Shisa5 shisa family member 5 JBrowse link 8 117,780,992 117,795,923 RGD:6907045
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:6907045
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:2316155
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:6484113
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:2316155
RGD:6484113
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G Tp53bp2 tumor protein p53 binding protein, 2 JBrowse link 13 100,817,206 100,873,837 RGD:8662965
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:6907045
G Trim28 tripartite motif-containing 28 JBrowse link 1 65,544,369 65,551,043 RGD:6484113
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:6907045
G Ttc5 tetratricopeptide repeat domain 5 JBrowse link 15 27,698,375 27,715,970 RGD:6484113
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 20 18,547,370 18,580,291 RGD:6484113
G Usp7 ubiquitin specific peptidase 7 JBrowse link 10 6,930,462 7,019,910 RGD:2316155
RGD:6484113
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:8662965
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:6484113
G Zfp385a zinc finger protein 385A JBrowse link 7 144,939,616 144,966,364 RGD:8662965
G Zfp420 zinc finger protein 420 JBrowse link 1 88,531,975 88,564,480 RGD:8662965
G Zmat3 zinc finger, matrin type 3 JBrowse link 2 118,715,229 118,746,109 RGD:6907045
G Znhit1 zinc finger, HIT-type containing 1 JBrowse link 12 22,726,643 22,732,917 RGD:8662965
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:8663430
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:2316186
RGD:8663434
G Mdm4 MDM4, p53 regulator JBrowse link 13 49,786,776 49,828,780 RGD:8663434
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:8663431
G Nfya nuclear transcription factor Y subunit alpha JBrowse link 9 14,551,752 14,577,002 RGD:8663431
RGD:8663430
G Nfyb nuclear transcription factor Y subunit beta JBrowse link 7 27,081,667 27,097,481 RGD:8663431
RGD:8663430
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:8663431
RGD:8663430
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:8663430
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:8663431
RGD:8663430
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2316186
RGD:8693397
RGD:8663430
RGD:8663431
RGD:5490966
RGD:5133242
RGD:4143515
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:8663431
RGD:8663430
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:8663431
RGD:8663430
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:8663430

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassTp53 regulators
Functional Classp53 dependent histone acetylation
Gene Groupp53 binding partners
Gene Groupp53 targets
Gene Groupnon-coding RNAs - p53 targets, regulators, effectors
Small MoleculeNOnitric oxide

Pathway Gene Annotations

Disease Annotations Associated with Genes in the p53 signaling pathway
Disease TermsGene Symbols
17-Hydroxysteroid Dehydrogenase DeficiencyRrm2b
abdominal aortic aneurysmMapk8 , Serpine1
abdominal obesity-metabolic syndrome 1Bax , Fas
Aberrant Crypt FociGsk3b
Abortion, SpontaneousCd82 , Igf1 , Igfbp3
acneIgf1
acoustic neuromaCdkn1a , Igf1 , Igfbp3
Acquired Protein C DeficiencySerpine1
acromegalyIgf1
Acute HepatitisTsc2
acute kidney failureBax , Fas , Gsk3b , Igf1 , Sirt1 , Tp53
Acute Liver FailureAtm , Casp3 , Casp9 , Fas , Mapk8
Acute Lung InjuryBax , Casp3 , Casp8 , Fas , Serpine1
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesAbl1
acute lymphocytic leukemiaPten
acute myeloid leukemiaAbl1 , Ccnd1 , Ccnd2 , Cdk6 , Cdkn2a , Crebbp , Fas , Mdm2 , Pou4f1 , Tp53 , Tsc2
acute myocardial infarctionCasp3 , Gsk3b
Acute Necrotizing PancreatitisCasp3 , Serpine1
acute promyelocytic leukemiaAkt1
acute T cell leukemiaBax
Acute-Phase ReactionIgfbp3
adenocarcinomaAbl1 , Casp8 , Ccnd1 , Cdkn2a , Pten , Rassf1 , Tp53
adenoid cystic carcinomaAtm , Brca1 , Ccnd1 , Crebbp , Ep300 , Pten , Tp53
adenomaIgf1 , Tp53
adenosine deaminase deficiencyBrca1
adrenal carcinomaTp53
Adrenal Gland NeoplasmsCdkn2a , Tp53
Adrenal InsufficiencyBax
adrenocortical carcinomaCdkn2a , Daxx , Tp53
adult respiratory distress syndromeMuc1 , Serpine1
adult T-cell leukemiaCsnk1a1 , Fas , Tp53 , Tp73
advanced sleep phase syndrome 2Csnk1d
Aggressive FibromatosisSerpine1
Aicardi-Goutieres syndromeKat5
AlbuminuriaIgf1 , Serpine1
Alcohol-Related DisordersCasp8
Alcoholic Fatty LiverSerpine1
Alcoholic Liver DiseasesNedd8
alcoholic neuropathyIgf1
allergic conjunctivitisMuc1
allergic contact dermatitisCasp8
allergic rhinitisSerpine1
alopeciaIgf1
alopecia areataHdac1
alveolar rhabdomyosarcomaTp73
Alzheimer's diseaseAbl1 , Akt1 , Atm , Bax , Casp3 , Casp8 , Casp9 , Ccng1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Ep300 , Fas , Gsk3b , Igf1 , Igfbp3 , Mapk14 , Mapk8 , Mapk9 , Mdm4 , Pin1 , Sirt1 , Tp53 , Tsc2
amphetamine abuseAkt1
amyloidosisSerpine1
amyotrophic lateral sclerosisAkt1 , Bax , Bid , Casp3 , Casp9 , Gsk3b , Mapk14 , Sirt1 , Tp53
amyotrophic lateral sclerosis type 1Crebbp
Anaplastic Thyroid CarcinomaTp53
anemiaCdk6
Anemia, Hypochromic Microcytic, with Iron OverloadSteap3
Anemia, Hypochromic Microcytic, with Iron Overload 2Steap3
angiomyolipomaPten , Tsc2
angiosarcomaCcnd1 , Tp53
Animal Disease ModelsAkt1 , Fas , Mapk8 , Mapk9 , Rrm2 , Serpine1 , Tp53
Animal Mammary NeoplasmsBrca1 , Ccnd1 , Cdk4 , Cdkn1a , Rassf1
anisometropiaPten
ankylosing spondylitisIgfbp3
anterolateral myocardial infarctionSerpine1
anti-basement membrane glomerulonephritisBax , Mapk14 , Mapk8
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas
aortic aneurysmSerpine1
Aortic RemodelingSerpine1
Aortic Valve, Calcification ofAkt1
aplastic anemiaFas
arrhythmogenic right ventricular cardiomyopathyPpp1r13l
Arsenic PoisoningCdkn1a , Gadd45b , Tp53
Arterial ThrombosisSerpine1
arteriosclerosisAtm , Igf1 , Igfbp3 , Mapk9
asthmaFas , Muc1 , Pin1 , Ppp2ca , Prmt5 , Pten , Serpine1
astrocytomaAdgrb1 , Akt1 , Ccnd1 , Chek2 , Nedd8 , Tp53
AtaxiaPten
ataxia telangiectasiaAtm
Ataxia-Telangiectasia VariantAtm
atherosclerosisAkt1 , Casp3 , Fas , Serpine1 , Sirt1
atopic dermatitisCasp8 , Mapk8
atrial fibrillationCdk6 , Cdkn1a , Sirt1
atrial heart septal defectCrebbp
attention deficit hyperactivity disorderCrebbp , Csnk1d
autism spectrum disorderPten , Tsc2
autistic disorderCcnb3 , Cop1 , Crebbp , Igf1 , Igfbp3 , Mdm4 , Pin1 , Pten , Serpine1 , Tsc2
Autoimmune DiseasesCasp8 , Fas , Sirt1
autoimmune lymphoproliferative syndromeCasp8 , Fas
autoimmune lymphoproliferative syndrome type 2BCasp8
autoimmune lymphoproliferative syndrome type 3Prkcd
Autoimmune Lymphoproliferative Syndrome, Type IAFas
autoimmune thrombocytopenic purpuraFas
autosomal dominant polycystic kidney diseaseCdkn1a
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive limb-girdle muscular dystrophy type 2ABrca1
autosomal recessive polycystic kidney diseaseAkt1
B-Cell Chronic Lymphocytic LeukemiaAtm , Fas , Pmaip1 , Tp53
B-cell lymphomaAtm , Kat5
bacterial conjunctivitisMuc1
bacterial infectious diseaseCasp3 , Casp8 , Casp9
bacterial pneumoniaSerpine1
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePten
Barrett's esophagusCdkn1a , Fas , Igfbp3 , Rprm
basal cell carcinomaTp53
Behcet's diseaseFas , Serpine1
beta thalassemiaIgfbp3
bilateral breast cancerAtm
biliary atresiaPten
biliary tract benign neoplasmMdm2 , Muc1
Binge DrinkingSirt1
bipolar disorderAkt1 , Gsk3b
bird fancier's lungMuc1
bladder diseaseRassf1
bladder urothelial carcinomaAkt1 , Cdkn2a , Crebbp , Ep300 , Pten , Tp53
blepharitisMuc1
bone development diseaseAbl1 , Tp53
Bone Marrow Failure Syndrome 5Tp53
Bone Marrow NeoplasmsTp53
Bowen's DiseaseCcne1 , Cdkn1a
Brain ContusionCasp3 , Casp8
brain diseasePten , Tsc2
brain gliomaBax , Casp3 , Fas
Brain HypoxiaEp300
brain infarctionSirt1
Brain InjuriesAkt1 , Apaf1 , Bax , Casp3 , Casp8 , Cdkn1a , Fas , Gsk3b , Igf1 , Mdm2 , Rchy1 , Sirt1 , Skp2
brain ischemiaAkt1 , Apaf1 , Bbc3 , Casp3 , Casp9 , Cycs , Fas , Igf1 , Mapk8 , Prkcd , Serpine1 , Tp53
Brain NeoplasmsCcnd1 , Cdk4 , Cdkn2a , Pten , Sirt1 , Tp53 , Tsc2
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a , Ppm1d
branched-chain keto acid dehydrogenase kinase deficiencyKat8
breast adenocarcinomaAkt1 , Ccne1 , Muc1 , Tp53
breast cancerAkt1 , Atm , Bax , Brca1 , Casp3 , Casp8 , Casp9 , Ccnb1 , Ccne1 , Cdk1 , Cdk2 , Cdk4 , Cdkn2a , Chek2 , Fas , Igf1 , Igfbp3 , Kat2b , Kat5 , Kat8 , Mdm2 , Muc1 , Ppm1d , Pten , Rassf1 , Serpine1 , Skp2 , Tp53 , Tp73 , Tsc2
Breast Cancer, FamilialAtm , Brca1 , Chek2 , Tp53
breast carcinomaAtm , Brca1 , Casp3 , Cd82 , Cdk4 , Ep300 , Fas , Hdac1 , Rrm2
breast ductal carcinomaBrca1 , Tp73 , Zfp420
Breast NeoplasmsAbl1 , Akt1 , Atm , Bax , Brca1 , Casp8 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Ep300 , Igf1 , Mdm2 , Mdm4 , Pin1 , Ppm1d , Pten , Rassf1 , Serpinb5 , Sirt1 , Tp53 , Tp53bp2 , Tp73 , Ybx1
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca1
bronchiolitis obliteransMuc1
bronchiolo-alveolar adenocarcinomaCcnd1 , Tp53
Bronchopulmonary DysplasiaBax , Bid , Casp3 , Casp8 , Casp9 , Muc1 , Serpine1 , Tp53
Burkitt lymphomaBbc3
BurnsBax , Casp3 , Ccnd1 , Gsk3b , Igf1 , Igfbp3 , Prkcd
calcinosisCasp3
CamptocormiaRrm2b
cancerCdkn2a , Pten , Tp53
cannabis abuseAkt1
CarcinogenesisAbl1 , Cdkn2a
carcinomaBrca1 , Ccnd1 , Cdk4 , Cdkn1a , Pten , Tp53
cardiac arrestAkt1 , Ep300
Cardiac FibrosisSerpine1
CardiomegalyAkt1 , Ccnd2 , Ep300 , Gsk3b , Igf1 , Kat8 , Mapk8 , Pin1 , Prkcd , Pten , Sirt1 , Yy1
cardiomyopathyAkt1 , Ep300 , Fas , Mapk14 , Tp53
CardiotoxicityTp53
carotid artery diseaseIgf1 , Tp53
Carotid Artery InjuriesCcna2 , Igf1 , Serpine1
Carotid AtherosclerosisSirt1
Castration-Resistant Prostatic NeoplasmsCcne2
cataractAtm , Casp3 , Casp9 , Fas , Pten , Tp53
Cecal NeoplasmsCcnd1 , Tp53
Cell Transformation, NeoplasticBrca1 , Ccnd1 , Gsk3b , Mapk8 , Mdm2 , Muc1 , Pten , Tp53
central nervous system diseaseCrebbp
Central Nervous System NeoplasmsTp53
Central Serous ChorioretinopathySerpine1
cerebellar ataxiaAtm
cerebral cavernous malformationPten
Cerebral HemorrhageBax , Casp3 , Casp8 , Casp9
cerebral infarctionSerpine1
cervical adenocarcinomaTp53
cervical cancerBrca1 , Casp3 , Ccnb1 , Cdk1 , Rassf1 , Tp53
cervical squamous cell carcinomaBax , Cd82 , Tp53
cervix carcinomaCcnd3 , Tp53
cervix uteri carcinoma in situBrca1 , Ccnd1 , Ccne1 , Ccng1 , Cdk4 , Cdkn1a , Cdkn2a , Hdac1 , Igfbp3 , Pou4f1 , Pten , Skp2 , Tp73
Charcot-Marie-Tooth disease dominant intermediate CYbx1
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBax , Casp8 , Fas , Gadd45a , Igf1 , Prkcd
chemical colitisCasp3
Chemotherapy-Induced Febrile NeutropeniaMdm2 , Tp53
Chest TraumaFas
Childhood SchizophreniaPpp1r13b
ChloracneCdk6 , Cycs , Gadd45a
cholangiocarcinomaCycs , Mdm2 , Muc1 , Pten , Tp53
cholestasisIgf1 , Mapk14 , Serpine1
cholesteatoma of middle earCdkn1a , Tp53
chorioamnionitisFas
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Choroidal Neovascularization, ExperimentalSerpine1
Chromosome 13q Deletion SyndromePou4f1
chromosome 13q14 deletion syndromePou4f1
Chromosome 17 DeletionTp53
chromosome 1q41-q42 deletion syndromeTp53bp2
Chromosome AberrationsCdk6
Chromosome BreakageBrca1
Chromosome DeletionCdkn2a
Chronic Allograft NephropathySerpine1
Chronic Cerebral HypoperfusionMapk14
chronic conjunctivitisFas
Chronic HepatitisCasp3
Chronic Intermittent HypoxiaBax
chronic lymphocytic leukemiaTp53
chronic myeloid leukemiaAbl1 , Akt1 , Cdkn2a , Fas , Mapk14 , Mdm2
chronic obstructive pulmonary diseaseCasp3 , Casp8 , Fas , Mapk8 , Muc1 , Serpine1 , Tp53
chronic progressive external ophthalmoplegiaRrm2b
Chronic Relapsing Experimental Autoimmune EncephalomyelitisSerpine1
Chronic UveitisFas
clear cell adenocarcinomaDaxx , Tp53
clear cell renal cell carcinomaEp300 , Kat8
clonorchiasisFas
Cockayne syndromeIgf1
cognitive disorderGsk3b , Mapk14
Cognitive DysfunctionTp53
colitisChek2 , Igf1 , Sirt1
colon adenocarcinomaBax , Daxx
colon cancerAkt1 , Apaf1 , Brca1 , Casp3 , Ccnd2 , Gsk3b , Pten , Tp53
colon carcinomaAkt1 , Bax , Ep300 , Tp53
Colonic NeoplasmsBax , Casp3 , Ccnd1 , Ccnd2 , Ccne1 , Cdkn1a , Cdkn2a , Fas , Gsk3b , Mapk8 , Serpinb5 , Tp53 , Ybx1
colorectal adenocarcinomaGsk3b , Mapk8 , Tp53
colorectal adenomaMapk8
colorectal cancerAdgrb1 , Akt1 , Casp9 , Chek2 , Ep300 , Hdac1 , Mapk9 , Tp53
Colorectal NeoplasmsAkt1 , Bax , Casp8 , Ccnd1 , Ccnd2 , Cdkn2a , Chek2 , Crebbp , Ep300 , Igfbp3 , Pten , Rrm2 , Serpinb5 , Tp53 , Trim28
Combined Oxidative Phosphorylation Deficiency 11Tp53
Combined Oxidative Phosphorylation Deficiency 3Rrm2b
common bile duct neoplasmMuc1
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyIgfbp3
Congenital CholesteatomaCdkn1a
congenital diaphragmatic herniaEp300 , Igf1 , Igfbp3
Congenital Disorder of Glycosylation Type 1AIgf1 , Igfbp3
congenital dyserythropoietic anemiaTp53
congenital heart diseaseAbl1
congenital hypoplastic anemiaTp53
congenital hypothyroidismIgf1
congenital myasthenic syndromeBrca1
congenital myasthenic syndrome 10Brca1
congestive heart failureBax , Casp3 , Ccna2 , Chek2 , Ep300 , Fas , Gsk3b , Igf1 , Kat8 , Ppp2ca , Serpine1 , Sirt1 , Tp53 , Yy1
contact dermatitisCasp8
Contrast-Induced NephropathyCasp3 , Mapk8
Copper-Overload CirrhosisCasp3
corneal diseaseIgf1
corneal neovascularizationFas
coronary artery diseaseAkt1 , Serpine1
Coronary DiseaseIgf1 , Igfbp3 , Kat2b
coronary restenosisTp53
coronary stenosisIgf1
Cowden syndromePten
Cowden Syndrome 6Akt1
Cowden-Like SyndromePten
Craniofacial AbnormalitiesApaf1 , Csnk1a1 , Ep300 , Pten , Tp53
Crohn's diseaseIgf1
cryptorchidismCasp3 , Fas
Currarino TriadZmat3
Cutaneous Malignant Melanoma, Susceptibility To, 1Cdkn2a
Cutaneous Malignant Melanoma, Susceptibility To, 2Cdkn2a
Cutaneous Malignant Melanoma, Susceptibility To, 3Cdk4
cutaneous T cell lymphomaAtm , Bax , Cdkn2a , Fas , Tp53
cystic fibrosisFas , Igf1 , Igfbp3 , Muc1
DeafnessIgf1
degenerative disc diseaseGsk3b
dementiaBax
demyelinating diseaseHdac1 , Igf1 , Sirt1 , Tp53
Dermal FibrosisSerpine1
dermatomyositisFas
developmental coordination disorderPten
Developmental DisabilitiesCrebbp , Ep300 , Pten
Diabetes ComplicationsCasp9 , Muc1
diabetes mellitusIgf1 , Pten , Serpine1 , Sirt1
Diabetes Mellitus, Experimental Akt1 , Bax , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnd3 , Cdkn1a , Ep300 , Fas , Hdac1 , Igf1 , Igfbp3 , Mdm2 , Prkcd , Serpine1 , Sirt1 , Tp53 , Tsc2
diabetic angiopathyCasp3 , Fas , Serpine1
Diabetic CardiomyopathiesCasp3 , Casp8 , Casp9 , Igf1
diabetic encephalopathyGsk3b
Diabetic FootIgf1
Diabetic NephropathiesCasp3 , Casp8 , Casp9 , Ccne1 , Cdkn1a , Ep300 , Fas , Gsk3b , Igf1 , Mapk14 , Pten , Serpine1 , Tp53
diabetic neuropathyCasp3 , Igf1 , Mapk14
diabetic retinopathyCasp3 , Casp9 , Ep300 , Igf1 , Serpine1 , Sirt1
Diamond-Blackfan anemiaRpl11 , Tp53
Diamond-Blackfan Anemia 6Tp53
Diamond-Blackfan Anemia 7Rpl11
Diaphragmatic HerniaIgf1
diffuse large B-cell lymphomaCdk1 , Cdkn2a , Fas , Skp2 , Tp53
dilated cardiomyopathyAtm , Bax , Casp3 , Casp8 , Casp9 , Fas , Igf1 , Mdm4 , Tp53
disease of cellular proliferationAtm , Brca1 , Cdkn2a , Chek2 , Mdm2 , Pten , Skp2 , Tp53 , Yy1
Disease ProgressionCcne1 , Chek2 , Pten , Ptpa , Rchy1 , Yy1
disseminated intravascular coagulationSerpine1
Down syndromeIgfbp3
Drug-Induced DyskinesiaGsk3b
Drug-induced NeutropeniaMdm2 , Tp53
Drug-Related Side Effects and Adverse ReactionsIgf1 , Tp53
dry eye syndromeMuc1
ductal carcinoma in situCcnd1 , Ccnd2 , Cdkn1a , Tp53
DwarfismEp300 , Igf1 , Igfbp3 , Tp53
dysgerminomaBrca1
dyskeratosis congenitaTp53
dysplastic nevus syndromeCdkn2a
early infantile epileptic encephalopathy 1Csnk1e
EdemaCasp3 , Casp8 , Casp9
embryonal carcinomaCcna2 , Chek2
EmphysemaTp53
end stage renal failureIgf1 , Serpine1
endometrial adenocarcinomaRrm2 , Tp53
endometrial cancerAtm , Cdkn2a , Pten , Tp53
endometrial carcinomaCcnb1 , Cd82 , E4f1 , Gsk3b , Pten , Rassf1 , Sfn , Tp53 , Tsc2
endometrial hyperplasiaPten , Skp2
Endometrial NeoplasmsCcnd1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Ep300 , Gsk3b , Hdac1 , Igfbp3 , Pten , Skp2 , Tp53 , Tp73
Endometrioid CarcinomasAkt1 , Ccne1 , Cdk2 , Chek2 , Daxx , Igfbp3 , Pten
endometriosisBax , Ccne2 , Hdac1 , Igf1
endometritisCasp3 , Casp9
endophthalmitisFas
EndotoxemiaBax , Casp3 , Casp9 , Ep300 , Fas , Igf1 , Igfbp3 , Mapk14 , Serpine1
epidermolysis bullosa dystrophicaIgfbp3
epilepsyAkt1 , Sirt1 , Tsc2
esophageal cancerTp53
esophageal carcinomaCdkn2a , Ep300 , Tp53
Esophageal NeoplasmsAbl1 , Bax , Bbc3 , Casp8 , Ccnd1 , Cdkn1a , Cdkn2a , Fas , Rprm , Sfn , Smyd2 , Tp53
esophagus adenocarcinomaCdkn2a , Fas , Tp53
esophagus squamous cell carcinomaKat2b
Experimental Allergic AsthmaFas
Experimental ArthritisAkt1 , Bax , Cdkn2a , Gsk3b , Igf1 , Igfbp3
Experimental Autoimmune EncephalomyelitisCasp3 , Casp8 , Casp9 , Igf1 , Serpine1 , Sirt1
Experimental Autoimmune MyocarditisCasp3 , Casp8 , Casp9 , Sirt1
Experimental Autoimmune UveitisFas
Experimental ColitisFas
Experimental LeukemiaCdkn2a
Experimental Liver CirrhosisApaf1 , Ccna2 , Ccnb2 , Ccng1 , Cdk1 , Cdk2 , Cdk4 , Cdkn1a , Fas , Igf1 , Igfbp3 , Prkcd , Sirt1 , Ybx1
Experimental Liver NeoplasmsBbc3 , Ccnb1 , Ccnd1 , Cdkn1a , Ppp2ca , Tp53
Experimental NeoplasmsAbl1 , Ccnd1 , Cdk4 , Tp53
extrahepatic cholestasisMapk14 , Mapk8 , Mapk9 , Setd7
Eye AbnormalitiesApaf1
facioscapulohumeral muscular dystrophyCdkn1a
Failure to ThriveAbl1
familial adenomatous polyposisAkt1
familial combined hyperlipidemiaSerpine1
familial hypercholesterolemiaSerpine1
familial Mediterranean feverIgf1 , Serpine1
familial melanomaCdk4 , Cdkn2a
familial meningiomaPten
Familial Prostate CancerAtm , Casp8 , Chek2
Fanconi anemiaBrca1
Fanconi anemia complementation group ABrca1
fatty liver diseaseCycs , Mapk8 , Prkcd , Pten , Serpine1 , Sirt1
Female InfertilityTp53 , Tsc2
Female Urogenital DiseasesIgf1
fetal alcohol spectrum disorderIgf1 , Pten
Fetal Growth RetardationBax , Casp3 , Fas , Hdac1 , Igf1 , Igfbp3 , Mdm2 , Muc1 , Serpine1
Fetal MacrosomiaIgf1 , Igfbp3 , Pten
FeverSerpine1
fibrosarcomaSerpine1
FibrosisAkt1 , Atm , Ccnd2 , Sirt1
Focal Cortical Dysplasia of TaylorTsc2
focal segmental glomerulosclerosisCasp9 , Serpine1
folic acid deficiency anemiaIgf1
follicular lymphomaCrebbp
follicular thyroid carcinomaPten
Fuchs' endothelial dystrophyCdkn1a
Funnel ChestTp53
GABRIELE-DE VRIES SYNDROMEYy1
gallbladder adenocarcinomaCdk1
gallbladder carcinomaTp53
Gallbladder NeoplasmsMuc1 , Tp53
gastric adenocarcinomaAkt1 , Cdkn2a , Crebbp , Pten , Tp53
gastric ulcerCasp3 , Fas
gastrointestinal carcinomaChek2
Gastrointestinal HemorrhageBax , Chek2
Gastrointestinal NeoplasmsPten
gastrointestinal stromal tumorDyrk2 , Hipk2
Gaucher's diseaseTp53
Gaucher's disease type ITp53
genetic diseaseApaf1 , Atm , Ccnd2 , Cdkn2a , Chek2 , Crebbp , Ep300 , Fas , Hdac1 , Ppm1d , Pten , Rpl11 , Tsc2 , Yy1
Genomic InstabilityCcnd1 , Sirt1
Germ Cell and Embryonal NeoplasmsCcnd2 , Ccne1 , Cdk4 , Cdkn2a
germinomaCcnd2 , Cdkn2a
glaucomaBax , Ccnd2 , Cdkn2a , Crebbp , Fas , Serpine1
glioblastoma multiformeAdgrb1 , Akt1 , Atm , Cdk4 , Cdk6 , Cdkn2a , Crebbp , Mdm2 , Mdm4 , Pten , Tp53
GliosisCd82
glomerulonephritisEp300 , Fas , Serpine1
glomerulosclerosisSerpine1
glucose intoleranceSirt1
grade III astrocytomaTp53
Graft vs Host DiseaseFas , Serpine1 , Tp53
granulomatosis with polyangiitisIgf1
granulosa cell tumorCcnd2 , Cdkn2a
Graves OphthalmopathyIgf1 , Serpine1
Graves' diseaseFas , Igf1 , Serpine1 , Tp53
Growth DisordersIgf1
growth hormone secreting pituitary adenomaCdkn1a
HamartomaTsc2
Hashimoto DiseaseFas
Head and Neck NeoplasmsTp53
head and neck squamous cell carcinomaAkt1 , Ccnd1 , Cdkn2a , Crebbp , Ep300 , Pten , Serpine1 , Tp53
Head Injuries, ClosedIgf1 , Igfbp3
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a , Igf1
Hearing Loss, SuddenIgf1 , Serpine1
heart diseaseBax , Casp3 , Casp8 , Casp9 , Ep300 , Gsk3b , Hdac1 , Mapk14 , Muc1 , Ppp2ca , Sirt1
heart valve diseaseCasp3
Heavy Metal ToxicityDaxx
hemangiomaPten , Tsc2
Hematologic NeoplasmsMuc1
hematopoietic system diseaseFas , Serpine1
HemorrhageSerpine1
Henoch-Schoenlein purpuraIgf1
Hepatic InsufficiencyMapk14
hepatitis BKat2a
hepatoblastomaTp53
hepatocellular adenomaPten
hepatocellular carcinomaAkt1 , Atm , Bid , Casp3 , Casp8 , Casp9 , Ccnb1 , Ccnb2 , Ccnd1 , Ccne1 , Cdk1 , Cdk4 , Cdkn1a , Cdkn2a , Crebbp , Ep300 , Fas , Gtse1 , Igf1 , Kat2b , Mdm2 , Pten , Rrm2 , Sfn , Skp2 , Tp53
HepatomegalyMapk14 , Pten
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeAtm , Brca1 , Chek2 , Tp53
Hereditary Neoplastic SyndromesAtm , Brca1 , Cdk4 , Cdkn2a , Chek1 , Chek2 , Csnk1a1 , Csnk1g3 , Ppm1d , Ppp2ca , Pten , Tp53 , Tsc2
Hereditary PancreatitisCasp9
hereditary spastic paraplegia 11Tp53
heroin dependenceFas
Hirschsprung Disease 1Crebbp , Tsc2
human immunodeficiency virus infectious diseaseBax , Cdkn1a , Fas , Gadd45a , Mdm2 , Sirt1 , Yy1
Huntington's diseaseBax , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Ep300 , Fas , Hdac1 , Igf1 , Sirt1
Hyaline Membrane DiseaseSerpine1
hydrocephalusCcnd2
HyperalgesiaEp300 , Igf1 , Mapk8 , Mapk9 , Ppp2ca
HypercholesterolemiaAtm , Casp3 , Casp9
hyperglycemiaCasp8
hyperinsulinismPrkcd , Pten
HyperoxiaCdk4 , Cdkn1a , Fas , Igf1
HyperparathyroidismCcnd1
HyperphagiaIgf1
HyperplasiaAkt1 , Bax , Brca1 , Ccnb1 , Ccnd1 , Cdkn1a , Cdkn2a
hypersplenismFas
hypertensionAkt1 , Bax , Brca1 , Casp3 , Casp8 , Casp9 , Ccne1 , Cd82 , Cdkn2a , Ep300 , Gsk3b , Igf1 , Mapk8 , Pin1 , Prkcd , Pten , Serpine1 , Tp53
hyperthyroidismSerpine1
hypertrophic cardiomyopathyCasp3 , Igf1 , Kat8 , Rassf1 , Tp53 , Yy1
HypertrophyCdkn1a , Pten , Sirt1
hypochromic microcytic anemiaSteap3
HypothermiaFas , Mdm2 , Prkcd
hypothyroidismIgf1
HypovolemiaCdkn1a
HypoxiaCasp3
Hypoxia-Ischemia, BrainBax , Casp3 , Casp8 , Casp9 , Daxx , Fas , Igf1 , Igfbp3 , Serpine1
ichthyosisIgfbp3 , Mdm2
idiopathic pulmonary fibrosisFas , Muc1
IgA glomerulonephritisFas
impotenceAkt1 , Bax , Casp3 , Ccnd1 , Ccnd2 , Igfbp3 , Sirt1
in situ carcinomaAkt1 , Ccnb1 , Cdkn2a , Pten , Sfn
inclusion body myositisCsnk1a1 , Fas
infectious mononucleosisFas
infertilityAtm
InflammationAkt1 , Tp73 , Tsc2
inflammatory bowel diseaseChek2 , Igfbp3 , Rassf1
Insulin ResistanceAtm , Casp3 , Casp8 , Fas , Igfbp3 , Prkcd , Pten , Serpine1 , Sirt1
Insulin-Like Growth Factor I DeficiencyIgf1
INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIESFbxo11
INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLDPpm1d
intellectual disabilityCcna2 , Ep300 , Pten , Tsc2 , Yy1
intermediate coronary syndromeAkt1
intermittent claudicationBax , Bbc3 , Casp3 , Mdm2
interstitial lung diseaseMuc1 , Serpine1
Intervertebral Disc DisplacementAkt1 , Igf1
intestinal diseaseBax , Casp3
Intestinal NeoplasmsBax , Cdkn1a , Gsk3b , Mapk8 , Prkcd
Intestinal PolypsCcnd1 , Serpine1
intestinal pseudo-obstructionPten
Intestinal Reperfusion InjuryCasp3 , Casp9 , Serpine1
Intimal HyperplasiaCdk2 , Mdm2
invasive ductal carcinomaAdgrb1 , Akt1 , Brca1 , Ccnd3 , Cdkn2a , Csnk1e , Serpinb5
invasive lobular carcinomaCcnd1 , Ccnd2 , Tp53bp2
inverted papillomaCdkn1a
iron deficiency anemiaKat5
ischemiaBax , Cycs , Mapk9 , Tp53
ischemic colitisSerpine1
juvenile polyposis syndromePten
juvenile rheumatoid arthritisGadd45a
Kaposi's sarcomaTp53
Kashin-Beck DiseaseBax , Fas
KeloidSerpinb5 , Sfn
keratosisTp53
kidney diseaseCasp3 , Casp8 , Casp9 , Cdkn1a , Igf1 , Rrm2b
Kidney NeoplasmsAkt1 , Ccnd1 , Cdkn2a , Chek2 , Rassf1 , Tsc2
Kidney Reperfusion InjuryApaf1 , Atm , Bax , Casp3 , Daxx , Ep300 , Fas , Muc1 , Sirt1
Knee OsteoarthritisBax , Igf1
Kuhnt-Junius degenerationIgf1 , Mapk8
lactic acidosisRrm2b
Language Development DisordersPten
Laron syndromeIgf1
laryngeal squamous cell carcinomaCdkn1a
Lead Poisoning, Nervous SystemEp300
Leber hereditary optic neuropathyTp53
Left Ventricular HypertrophyPrkcd , Pten , Sirt1
leiomyomaBax , Ccng1 , Pten , Tsc2
leiomyosarcomaCdkn2a , Chek2
LEOPARD syndromePpp1r13l , Pten
leukemiaAtm , Ccnd1 , Cdkn2a , Daxx , Ppp1r13l , Pten , Tp53
Leydig cell tumorCdk4 , Prmt5
Li-Fraumeni syndromeChek2 , Tp53
Li-Fraumeni Syndrome 1Tp53
Li-Fraumeni Syndrome 2Chek2 , Tp53
Li-Fraumeni-Like SyndromeTp53
limited sclerodermaFas , Serpine1
Lip NeoplasmsCdkn1a , Tp53
lipoid nephrosisCdkn1a
lipomaPten
lipomatosisPten
liposarcomaCdk4
Lipoyltransferase 1 DeficiencyTp53
liver benign neoplasmAbl1 , Ccnd1 , Cdkn1a , Cdkn2a , Mapk14 , Serpine1 , Tp53
liver cancerAkt1 , Casp8 , Cdkn2a , Crebbp , Tp53
liver cirrhosisCasp3 , Casp8 , Casp9
liver diseaseFas , Mdm2 , Serpine1
Liver InjurySirt1
Liver Reperfusion InjuryBax , Casp8 , Casp9 , Fas , Gsk3b , Mapk8 , Muc1 , Serpine1 , Sirt1
localized sclerodermaCdkn1a
long QT syndromePten
low tension glaucomaTp53
lung adenocarcinomaAkt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Muc1 , Tp53
lung cancerCasp8 , Tp73
lung diseaseMuc1 , Serpine1
Lung InjurySirt1
Lung NeoplasmsAkt1 , Casp8 , Ccnd1 , Ccng1 , Cdkn1a , Cdkn2a , Chek2 , Fas , Mapk14 , Pten , Rassf1 , Rchy1 , Tp53 , Tp73
Lung Reperfusion InjuryBax , Casp3 , Serpine1
lung small cell carcinomaAkt1 , Ccnd1 , Crebbp , Ep300 , Pten , Skp2 , Tp53
lung squamous cell carcinomaAkt1 , Ccnd1 , Cdk4 , Cdkn2a , Crebbp , Cycs , Ep300 , Pten , Tp53
lymphangioleiomyomatosisTsc2
Lymphatic MetastasisAdgrb1 , Casp9 , Ccne1 , Cdkn1a , Cycs , Fas , Muc1 , Pten , Sfn , Skp2 , Tp53 , Tsc2
lymphomaAtm , Ccnb1 , Cdkn2a , Pten , Rpl11 , Tp53
Lymphoma, Extranodal NK-T-CellFas
lymphoproliferative syndromeFas
Lynch syndromeFbxo11
MacrocephalyCcnd2 , Pten , Usp7
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessivePten , Usp7
macular degenerationBax , Cdkn1a , Fas , Serpine1 , Sirt1
male breast cancerChek2
Male Breast NeoplasmsChek2
male infertilityBax , Fas , Mdm2 , Tp53
malignant gliomaCcnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Fas , Igf1 , Igfbp3 , Ppm1d , Pten , Rassf1 , Serpine1 , Tp53
malignant mesotheliomaCcne2 , Cdk6 , Cdkn1a , Cdkn2a , Muc1 , Tp53
MalocclusionIgf1 , Igfbp3
Mammary Neoplasms, ExperimentalAkt1 , Apaf1 , Bax , Brca1 , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnd1 , Ccnd3 , Ccne1 , Cdk2 , Cdk4 , Cdk6 , Cdkn2a , Fas , Gsk3b , Igf1 , Muc1 , Pin1 , Pten , Tp53
mantle cell lymphomaAtm , Ccnd1 , Gsk3b
marginal zone B-cell lymphomaTp53
maxillary sinus squamous cell carcinomaCdkn1a
McCune Albright syndromeIgfbp3
measlesMuc1
Medullary Cystic Kidney Disease 1Muc1
medulloblastomaCcnd1 , Ccne1 , Cdk6 , Crebbp , Ep300 , Rassf1 , Skp2 , Tp53 , Tsc2
Megakaryoblastic Leukemia of Down SyndromeTp53
megakaryocytic leukemiaPten , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeCcnd2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3Ccnd2
melanomaAkt1 , Atm , Casp8 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Fas , Mdm2 , Ppp2ca , Pten , Tp53
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma-Pancreatic Cancer SyndromeCdkn2a
membranoproliferative glomerulonephritisCdk2 , Ep300
Memory DisordersAbl1
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pten
Menke-Hennekam Syndrome 1Crebbp
Menke-Hennekam Syndrome 2 Ep300
mental depressionBax , Gsk3b
MesotheliomaCdkn2a , Muc1 , Rassf1 , Tp53
Metabolic Bone DiseasesIgf1 , Igfbp3
Metabolic Brain DiseasesFas
Metabolic SyndromeAtm , Chek2 , Serpine1 , Sirt1
methylmalonic acidemiaCycs
microcephalyEp300 , Igf1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveCdkn2a , Rassf1
Microsatellite InstabilityBax
middle cerebral artery infarctionApaf1 , Bax , Casp3 , Casp9 , Gsk3b , Igf1 , Serpine1 , Sirt1
mitochondrial DNA depletion syndrome 8ARrm2b
Mitochondrial DNA Depletion SyndromesRrm2b
mitochondrial metabolism diseaseRrm2b
mitochondrial myopathyRrm2b
mixed connective tissue diseaseFas
morphine dependenceBax
mouth diseaseBrca1
Mouth NeoplasmsCdkn2a , Pten , Sfn , Tp53 , Tsc2
Moyamoya diseaseFas
mucinous adenocarcinomaMuc1
Mucinous CystadenomaDaxx
Multi-Infarct DementiaBax
Multiple AbnormalitiesAtm , Crebbp , Ep300 , Gsk3b , Hdac1 , Pten
Multiple Hamartoma SyndromePten
multiple myelomaCcnd1 , Ccnd2 , Ccnd3 , Cdk4 , Cdkn2a , Muc1 , Tp53
Multiple Organ FailureSerpine1
multiple sclerosisFas , Hdac1
multiple system atrophyFas
Multiple TraumaSerpine1
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscle HypotoniaRrm2b , Usp7
Muscle SpasticityCrebbp
muscular atrophyAkt1 , Apaf1 , Gsk3b , Igf1 , Serpine1
muscular diseasePrkcd
muscular dystrophyPten
Muscular Dystrophy-Dystroglycanopathy (congenital with brain and eye anomalies), Type A, 11Brca1
Musculoskeletal AbnormalitiesAbl1
myasthenia gravisFas
Mycoplasma InfectionsCasp3
myelodysplastic syndromeCdkn2a , Crebbp , Fas , Mdm2 , Tp53
myelofibrosisTp53
myeloid leukemiaIgfbp3
Myeloid Leukemia, Chronic-PhaseAbl1
myocardial infarctionAkt1 , Atm , Bax , Casp3 , Ccna2 , Gsk3b , Igf1 , Serpine1 , Sirt1 , Tp53 , Ybx1
Myocardial IschemiaBax , Ccna2 , Ccnd1 , Ccnd2 , Igf1 , Igfbp3 , Mapk14 , Ppp2ca , Prkcd
Myocardial Reperfusion InjuryAkt1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Fas , Gsk3b , Mapk14 , Mapk8 , Mdm2 , Prkcd , Pten , Serpine1 , Sirt1 , Tp53
myopiaIgf1
nasal cavity cancerTp53
Nasal PolypsFas , Igf1
Nasopharyngeal NeoplasmsCcnd1 , Tp53
nasopharynx carcinomaTp53
NecrosisFas
nemaline myopathy 6Csnk1g1
NeointimaIgf1 , Pin1 , Serpine1 , Yy1
Neoplasm InvasivenessCd82 , Cdkn2a , Igf1 , Pten , Tp53bp2
Neoplasm MetastasisAdgrb1 , Bax , Casp3 , Ccna2 , Ccnd1 , Ccnd2 , Ccne1 , Cd82 , Cdkn1a , Cdkn2a , Chek1 , Daxx , Fas , Igf1 , Mapk9 , Muc1 , Pten , Serpinb5 , Sirt1 , Tp53
Neoplasm MicrometastasisCycs
Neoplasm Recurrence, LocalYbx1
Neovascularization, PathologicSerpine1
nephritisCasp8 , Ccnd2 , Fas
nephroblastomaCcnd2 , Cdk4 , Cdkn2a , Chek2 , Tp53 , Tp73
nephrogenic diabetes insipidusSirt1
nephronophthisis-like nephropathy 1Ep300
nephrosclerosisHipk2
Nephrosis, Puromycin AminonucleosideFas
nephrotic syndromeSerpine1
Nerve DegenerationBax , Casp3 , Igf1 , Sirt1 , Tsc2 , Zmat3
Nerve Sheath NeoplasmsCdkn2a , Pten , Tp53
nervous system diseaseCasp3 , Casp9 , Serpine1 , Tp53
Nervous System MalformationsTp73
neural tube defectApaf1 , Kat2a
neurilemmomaCdkn2a , Serpine1
neuroblastomaCdkn2a , Chek2 , Rassf1 , Tp53 , Tp73 , Tsc2
neurodegenerative diseaseSirt1
Neurodevelopmental DisordersPpm1d , Pten
neuroendocrine tumorDaxx
Neurologic ManifestationsTp73
neuronal ceroid lipofuscinosis 1Sirt1
neuronal ceroid lipofuscinosis 6Gsk3b
Niemann-Pick diseaseAbl1
Niemann-Pick disease type C1Abl1
non-functioning pancreatic endocrine tumorCdk4 , Cdk6
non-Hodgkin lymphomaCcnd1 , Chek2 , Tp53
non-small cell lung carcinomaAkt1 , Apaf1 , Casp3 , Casp8 , Casp9 , Ccnd1 , Ccne1 , Cdk4 , Cdk6 , Cdkn2a , Cycs , Kat2a , Mdm2 , Pten , Rassf1 , Tp53
nonalcoholic fatty liver diseaseFas , Igf1 , Mapk8 , Prkcd , Serpine1 , Sirt1
Noonan syndromeApaf1 , Igf1 , Serpine1
NSAID-EnteropathyCasp9
obesityAkt1 , Cdk4 , Cdkn2a , Cycs , Ep300 , Igfbp3 , Prkcd , Serpine1 , Sirt1
obstructive sleep apneaMuc1 , Serpine1
ocular hypertensionCdkn1a , Fas
Oculomotor Apraxia, Cogan TypeAtm
Odontogenic MyxomaTp53
Optic Nerve InjuriesBax , Cdk2 , Ep300
Oral Lichen PlanusCdkn1a , Tp53
oral mucosa leukoplakiaCdkn1a , Tp53
oral squamous cell carcinomaCdkn1a , Serpine1
oral submucous fibrosisTp53
ornithine carbamoyltransferase deficiencyIgfbp3
Oropharyngeal NeoplasmsTp53
osteoarthritisBax , Casp3 , Casp9 , Cdkn2a , Igf1 , Igfbp3
Osteoarthritis, ExperimentalCasp3 , Casp8
Osteoarthritis, Temporomandibular JointFas
osteochondrodysplasiaPten
OsteophytesIgf1
osteoporosisAbl1 , Atm , Bax , Igf1 , Igfbp3 , Mapk14 , Sirt1
Osteoporotic FracturesIgf1
osteosarcomaAkt1 , Ccnb3 , Chek2 , Sirt1 , Tp53 , Tsc2
otitis mediaFbxo11 , Muc1 , Tp73
ovarian cancerAkt1 , Brca1 , Cd82 , Fas , Rassf1 , Sfn , Tp53
ovarian carcinomaCcnd1 , Ccne1
Ovarian NeoplasmsAkt1 , Brca1 , Ccnd2 , Ccne1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Gadd45a , Gsk3b , Hdac1 , Igfbp3 , Pten , Rassf1 , Skp2 , Tp53 , Tp73
ovarian serous cystadenocarcinomaTp53
ovarian small cell carcinomaTp53
ovary adenocarcinomaCcnd3
ovary epithelial cancerCcnb1 , Daxx
ovary serous adenocarcinomaBrca1 , Tp53
Oxygen-Induced RetinopathyFas , Igf1 , Mapk8 , Serpine1
PainAkt1
Painful NeuropathyEp300
pancreatic adenocarcinomaAdgrb1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk9 , Tp53
pancreatic cancerAkt1 , Apaf1 , Atm , Bid , Brca1 , Casp8 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Chek1 , Cycs , Daxx , Gadd45a , Igf1 , Muc1 , Pten , Rrm2 , Tp53 , Tsc2
pancreatic carcinomaBrca1 , Cdkn1a , Cdkn2a , Tp53
pancreatic ductal adenocarcinomaCcnd1 , Cdk4 , Mapk8
pancreatic ductal carcinomaCcnd1 , Cdk6 , Cdkn1a , Cdkn2a , Hdac1 , Igf1 , Mdm2 , Muc1 , Tsc2
pancreatic endocrine carcinomaDaxx
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1 , Hdac1
Pancreatic Islet Cell TumorsCdk4 , Daxx
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisCasp3 , Mdm2
Pancreatitis, Experimental, Acute Cdkn1a
pancytopeniaTp53
papillary renal cell carcinomaAtm , Cdkn2a , Pten , Tp53
papillary thyroid carcinomaCcnd1
papillomaCcnd1 , Cdkn1a
Papillomavirus InfectionsCasp8 , Cdkn2a
ParalysisSirt1
paranasal sinus neoplasmTp53
paraplegiaAkt1
Parasitic Liver DiseasesTp53
Parkinson's diseaseAbl1 , Akt1 , Apaf1 , Atm , Casp3 , Casp9 , Fas , Gsk3b , Nedd8 , Ppp2ca
Parkinsonian DisordersApaf1 , Casp3 , Casp9 , Prkcd
Pediatric Adrenocortical CarcinomaTp53
PEHO SyndromeIgf1
penile neoplasmCcnd1 , Tp53
peripheral artery diseaseSerpine1
peripheral nervous system diseaseCasp9 , Cdkn2a , Igf1
peripheral nervous system neoplasmPten
peripheral T-cell lymphomaAtm
peripheral vascular diseaseFas
Perisylvian SyndromeCcnd2
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisSerpine1
Peritoneal NeoplasmsMuc1
peritonitisGsk3b
persistent fetal circulation syndromePten
persistent hyperplastic primary vitreousCdkn2a
Phyllodes TumorCdkn1a , Tp53
Pierson syndromeCdkn2a
Pituitary NeoplasmsCdkn1a , Igf1
placental insufficiencySerpine1
Plaque, AtheroscleroticIgf1
plasmacytomaCdk4 , Cdkn2a , Tp53
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Plasmodium falciparum malariaFas
platelet-type bleeding disorder 10Serpine1
pleomorphic xanthoastrocytomaCdk6 , Cycs , Igfbp3 , Serpine1 , Tp53 , Znhit1
pleurisySerpine1
pleuropulmonary blastomaYy1
Pneumococcal PneumoniaSirt1
pneumoconiosisMdm4
pneumocystosisMuc1
pneumoniaMuc1 , Serpine1 , Sirt1
PoisoningCdkn2a , Gsk3b
polycystic ovary syndromeBax , Ccnb1 , Ccne2 , Igf1 , Rrm2 , Serpine1
polycythemiaSerpine1
polydactylyPten
polyneuropathySerpine1
PolyploidyChek1 , Tp53
Porokeratosis 2, Palmar, Plantar, and Disseminated TypeBrca1
portal hypertensionPrkcd , Pten
post-traumatic stress disorderBax , Casp9 , Mdm2
Postaxial Polydactyly, Type A1Ccnd2
Postmenopausal OsteoporosisIgf1
pre-eclampsiaFas , Serpine1
pre-malignant neoplasmAbl1 , Akt1 , Atm , Bax , Bid , Casp3 , Casp8 , Casp9 , Ccnd1 , Cdkn1a , Cdkn2a , Fas , Mapk8 , Mapk9 , Mdm2 , Muc1 , Ppm1d , Tp53 , Tsc2
Precocious PubertyIgf1
precursor B lymphoblastic lymphoma/leukemiaAbl1 , Ccnd1 , Cdkn2a , Tp53
precursor lymphoblastic lymphoma/leukemiaAbl1 , Bax , Casp8 , Ccnd1 , Cdk6 , Cdkn2a , Crebbp , Fas , Hdac1 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaBax , Ccnd3 , Cdkn2a , Rpl11
Pregnancy ComplicationsSerpine1
Pregnancy Complications, CardiovascularFas
Premature AgingBax , Brca1 , Cdkn1a , Cdkn2a , Mdm2 , Tp53
Prenatal Exposure Delayed EffectsAtm
priapismMdm2
primary autosomal recessive microcephaly 12Cdk6
primary biliary cirrhosisCdkn1a , Mapk14
primary immunodeficiency diseaseCasp8
primary open angle glaucomaCdkn1a , Tp53
primary progressive multiple sclerosisIgfbp3
primary pulmonary hypertensionHdac1
prion diseaseBax
progeriaIgf1
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 5Rrm2b
proliferative diabetic retinopathySerpine1
Prolymphocytic Leukemia, T-CellAtm
prostate adenocarcinomaAkt1 , Ccnb1 , Ccne2 , Cdkn2a , Pten , Tp53
prostate cancerAkt1 , Bax , Brca1 , Casp3 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Cd82 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Daxx , Ep300 , Fas , Igfbp3 , Muc1 , Ppp2ca , Pten , Rassf1 , Sirt1 , Skp2 , Tp53 , Tp73 , Trim28 , Zmat3
Prostate Cancer, SomaticChek2 , Pten
prostate carcinomaBax , Skp2 , Tp53 , Tp73
prostate carcinoma in situAtm , Ccnd1 , Ccne1 , Hdac1 , Igf1 , Pten
prostatic hypertrophyCcnb1 , Cdk4 , Pten , Tp73
Prostatic NeoplasmsAkt1 , Atm , Bax , Brca1 , Casp3 , Casp9 , Ccna2 , Ccnd1 , Ccnd2 , Ccne1 , Cdk1 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ei24 , Fas , Gadd45a , Gsk3b , Hdac1 , Igf1 , Igfbp3 , Kat5 , Mdm2 , Pten , Rassf1 , Rpl11 , Serpine1 , Sesn3 , Sirt1 , Tp53 , Usp7
proteinuriaFas
Proteus syndromeAkt1 , Pten
psoriasisCdkn1a , Igf1 , Tp53
PTEN hamartoma tumor syndromePten
pterygiumTp53
pulmonary fibrosisIgf1 , Igfbp3 , Serpine1
pulmonary hypertensionCdkn1a , Hdac1 , Serpine1 , Tp53
pulmonary sarcoidosisMuc1
punctate palmoplantar keratoderma type IIBrca1
pycnodysostosisIgf1
Radiation Injuries, ExperimentalCasp3 , Casp8 , Casp9 , Fas
Radiation NephropathySerpine1
rectal neoplasmMapk8
RecurrenceCcne1
Refractory AnemiaYbx1
relapsing-remitting multiple sclerosisFas , Serpine1
renal carcinomaPten , Tp53
renal cell carcinomaAdgrb1 , Akt1 , Apaf1 , Atm , Casp3 , Ccnb1 , Ccnd1 , Ccnd3 , Ccne1 , Cdk2 , Cdk4 , Cdkn2a , Fas , Igfbp3 , Muc1 , Pten , Rassf1 , Skp2 , Tp53 , Tp73 , Tsc2
renal fibrosisSerpine1
renal hypertensionCdkn1a
Renal IschemiaApaf1
Reperfusion InjuryAkt1 , Apaf1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Ccnb1 , Ccnd1 , Ccne1 , Ccng1 , Cdkn1a , Ep300 , Fas , Igf1 , Mapk8 , Mapk9 , Muc1 , Pten , Tp53
respiratory allergySerpine1
restrictive cardiomyopathyMapk14 , Prkcd
Retina Reperfusion InjuryApaf1 , Bax
retinal degenerationBax
retinal detachmentApaf1 , Casp3 , Casp8 , Casp9 , Fas
retinal diseaseCasp3 , Sirt1
retinal vein occlusionSerpine1
retinitis pigmentosaPten
retinoblastomaFas
retinopathy of prematurityIgf1 , Igfbp3 , Serpine1
RetrognathiaEp300
rhabdomyosarcomaBrca1 , Cdkn2a , Tp53
rheumatic heart diseaseIgf1
rheumatoid arthritisCdk6 , Fas , Igfbp3
rhinitisSerpine1
RhinosinusitisIgf1 , Serpine1
Right Ventricular HypertrophyAkt1 , Hdac1 , Igf1 , Prkcd
Rubinstein-Taybi syndromeCrebbp , Ep300
salivary gland diseaseCasp3
Salivary Gland NeoplasmsCcnd1 , Cdkn1a
SAPHO syndromeMdm2 , Tp53
sarcoidosisCdkn1a
sarcomaChek2 , Mdm2 , Tp53
sarcomatoid mesotheliomaCdkn2a
SarcopeniaBax , Cdkn1a , Igf1
schistosomiasisRassf1
schizophreniaAkt1 , Cdkn2a , Chek1 , Ei24 , Gsk3b , Mapk8 , Tp53
sciatic neuropathyCasp3 , Casp8 , Fas , Gsk3b , Rchy1 , Serpine1
scoliosisCrebbp
scrapieBax , Casp3 , Casp9
sebaceous gland neoplasmCdkn1a
secondary hyperparathyroidismPin1
seminomaCcnd2 , Chek2 , Fas , Prmt5
senile cataractSirt1
SepsisCasp3 , Casp8 , Casp9 , Cdkn1a , Ep300 , Fas , Gsk3b , Serpine1
serous cystadenocarcinomaCdkn1a , Tp53
Serous CystadenomaDaxx
Sezary's diseaseCdkn2a , Crebbp , Pten , Tp53
Shock, HemorrhagicCasp3 , Casp8 , Sirt1
sickle cell anemiaMdm2
silicosisPten
Sjogren's syndromeFas
Skin AbnormalitiesApaf1
skin diseaseGadd45b , Pten
skin melanomaAkt1 , Cdk4 , Cdkn2a , Pten
Skin NeoplasmsAkt1 , Casp8 , Cdkn1a , Igf1 , Tp53
Skull FracturesIgf1
sleep apneaSerpine1
small cell carcinomaRassf1 , Tp53
spermatic cord torsionCasp3
spina bifidaCrebbp
Spinal Cord CompressionFas
Spinal Cord InjuriesAkt1 , Apaf1 , Atm , Bax , Casp3 , Casp9 , Ccnd3 , Ccne1 , Cdk1 , Fas , Mdm2 , Siah1 , Tp53
Spinal Cord Reperfusion InjurySiah1
Spinal FracturesIgfbp3
Spinocerebellar AtaxiasKat2a
SplenomegalyFas
sporadic breast cancerPten
Sporadic Papillary Renal Cell CarcinomaCdkn2a , Tp53
squamous cell carcinomaAkt1 , Atm , Ccnd1 , Cdkn1a , Cdkn2a , Crebbp , Ep300 , Fas , Hdac1 , Sfn , Tp53 , Tsc2
squamous cell neoplasmChek2
Stargardt diseaseChek2
Stargardt Disease 1Chek2
status epilepticusAtm , Bax , Casp3 , Casp8 , Ccnd1 , Gsk3b
Stevens-Johnson syndromeEp300
stomach cancerAdgrb1 , Tp53
stomach carcinomaCdkn1a
stomach diseasePten
Stomach NeoplasmsAtm , Bid , Casp8 , Ccnd1 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Gadd45a , Igfbp3 , Mapk8 , Muc1 , Ptpa , Serpine1 , Tp53
StrokeAkt1 , Casp3 , Cdk6 , Hdac1 , Igf1 , Mapk8 , Prkcd , Serpine1
Subarachnoid HemorrhageCasp3 , Casp9 , Gsk3b
substance-induced psychosisAkt1
substance-related disorderGsk3b , Pmaip1 , Pten
systemic lupus erythematosusCdkn1a , Ep300 , Fas , Gadd45a
systemic sclerodermaIgfbp3 , Muc1 , Serpine1 , Sirt1
T-cell leukemiaCdkn2a
T-Cell LymphomaAkt1 , Cdkn1a , Ep300 , Tp53
TachycardiaGsk3b
Taste DisordersFas
tauopathyGsk3b , Hdac1
teratomaBax
Testicular InjuryFas
Testicular NeoplasmsCcnd2
Testis Reperfusion InjuryApaf1 , Bax , Casp3 , Casp9
ThinnessIgf1
thoracic aortic aneurysmFas , Serpine1
thrombocytopeniaChek2 , Cycs
Thrombocytopenia 4Cycs
thrombosisSerpine1 , Sirt1
Thumb DeformityCrebbp , Ep300
thymomaCdkn2a , Tp53
Thymus NeoplasmsTp53
Thyroid NeoplasmsAkt1 , Ccnd1 , Cdk1 , Cdkn1a , Pten , Tp53
thyroiditisBax
Tongue NeoplasmsCdkn1a , Cdkn2a , Igf1 , Tp53
tongue squamous cell carcinomaCdkn1a , Tp53
tonsillitisIgfbp3
toxic encephalopathyCasp3 , Prkcd
toxic shock syndromeSerpine1
toxoplasmosisBax
transient cerebral ischemiaBax , Bbc3 , Casp3 , Casp8 , Casp9 , Cdkn2a , Cycs , Daxx , Ep300 , Fas , Igf1 , Mdm2 , Pten , Serpine1
transitional cell carcinomaAkt1 , Apaf1 , Casp3 , Ccnd1 , Ccnd2 , Cd82 , Cdk1 , Cdk4 , Cdkn1a , Cdkn2a , Crebbp , Daxx , Ep300 , Fas , Igfbp3 , Pten , Rassf1 , Sfn , Skp2 , Tp53 , Tp73
Translocation, GeneticCdkn2a
Transplant RejectionPin1
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaMapk8 , Mapk9
Triple Negative Breast NeoplasmsChek2
triple-receptor negative breast cancerTp73
TrisomyCdkn2a
tuberous sclerosisTsc2
tuberous sclerosis 2Tsc2
Tubulointerstitial Nephritis and UveitisMuc1
Tumor Predisposition SyndromeAtm , Brca1 , Cdk4 , Cdkn2a , Chek2 , Pten , Tp53 , Tsc2
Turner syndromeIgf1 , Igfbp3
type 1 diabetes mellitusCasp3 , Casp8 , Casp9 , Cdk4 , Fas , Hdac1 , Igf1 , Igfbp3 , Yy1
type 2 diabetes mellitusAkt1 , Bax , Casp3 , Casp8 , Casp9 , Ccnd2 , Cdk4 , Ep300 , Fas , Gsk3b , Hdac1 , Igf1 , Igfbp3 , Mapk8 , Mapk9 , Ppp2ca , Serpine1 , Sirt1
ulcerative colitisCasp3 , Cdkn1a , Fas
UnconsciousnessPten
ureteral obstructionAbl1 , Akt1 , Casp3 , Casp9 , Hipk2 , Serpine1
urinary bladder cancerAkt1 , Atm , Bax , Brca1 , Casp3 , Casp9 , Ccnd1 , Ccnd3 , Ccne1 , Cd82 , Cdk1 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Fas , Igf1 , Igfbp3 , Mdm2 , Muc1 , Pten , Rassf1 , Rrm2 , Serpine1 , Sfn , Tp53 , Tp73 , Usp7
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Tp53
uterine carcinosarcomaCdkn2a , Pten , Tp53
Uterine Cervical NeoplasmsAkt1 , Casp8 , Ccnd1 , Ccne1 , Ccng1 , Cdk2 , Cdk4 , Cdkn1a , Cdkn2a , Chek2 , Crebbp , Ep300 , Hdac1 , Igfbp3 , Pou4f1 , Pten , Skp2 , Tp53 , Tp73 , Yy1
uterine fibroidTsc2
Uterine NeoplasmsPten , Tp53
uveal melanomaIgf1 , Serpine1
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9 , Fas
vascular dementiaGsk3b , Igf1 , Tp53
Vascular DepressionSerpine1
Vascular RemodelingSerpine1
Venous ThromboembolismSerpine1
Venous ThrombosisSerpine1
Ventilator-Induced Lung InjuryAkt1 , Gadd45a , Serpine1
Ventricular Dysfunction, LeftAtm , Fas
Viral BronchiolitisMuc1
Viral MyocarditisCasp3 , Casp8
visual epilepsyApaf1 , Ccnb1 , Ccnd1 , Fas , Prkcd , Pten , Tsc2
von Hippel-Lindau diseaseCcnd1
vulva squamous cell carcinomaSfn
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Chek2 , Tp53 , Tp73
Wallerian DegenerationSirt1
West syndromeTsc2
Wounds and InjuriesIgf1
Wounds, PenetratingSerpine1
xeroderma pigmentosumTp53
Zinc DeficiencyIgf1
Pathway Annotations Associated with Genes in the p53 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Ccnd1
adenine phoshoribosyltransferase deficiency pathwayRrm2
adenosine monophosphate deaminase deficiency pathwayRrm2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp2ca
adenosine signaling pathwayAkt1 , Mapk8
adenylosuccinate lyase deficiency pathwayRrm2
AICA-ribosuria pathwayRrm2
aldosterone signaling pathwayCrebbp , Daxx , Igf1 , Sfn
allograft rejection pathwayFas
altered G1/S transition pathwayCdkn2a
altered insulin-like growth factor signaling pathwayIgf1
altered p53 signaling pathwayMdm2 , Mdm4 , Pin1 , Tp53 , Tp73
altered phosphatidylinositol 3-kinase signaling pathwayPten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pten
Alzheimer's disease pathwayApaf1 , Bid , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Fas , Gsk3b
amyotrophic lateral sclerosis pathwayApaf1 , Bax , Bid , Casp3 , Casp9 , Cycs , Cyct , Daxx , Mapk14 , Tp53
androgen signaling pathwayCrebbp , Ep300
apoptotic cell death pathwayAkt1 , Apaf1 , Atm , Bax , Bid , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Fas , Tp53
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm , Brca1 , Kat5 , Ppm1d , Ppp2ca
autoimmune thyroiditis pathwayFas
azathioprine pharmacodynamics pathwayRrm2
B cell receptor signaling pathwayAkt1 , Gsk3b
basal cell carcinoma pathwayGsk3b , Tp53
beta-ureidopropionase deficiency pathwayRrm2 , Rrm2b
Bone morphogenetic proteins signaling pathwayGsk3b
c-Jun N-terminal kinases MAPK signaling pathwayMapk8 , Mapk9
calcium/calmodulin dependent kinase 2 signaling pathwayPpp2ca
cardiolipin metabolic pathwayCycs
cardiovascular system disease pathwayIgf1
carnitine biosynthetic pathwaySetd7
cell cycle pathway, mitoticAbl1 , Atm , Ccna2 , Ccnb1 , Ccnb2 , Ccnb3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Crebbp , Ep300 , Gadd45a , Gadd45b , Gadd45g , Gsk3b , Hdac1 , Mdm2 , Sfn , Skp2 , Tp53
ceramide signaling pathwayAkt1 , Bax , Bid , Casp8 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Cycs , Igf1 , Mapk8 , Mapk9 , Prkcd , Tp53
Chagas disease pathwayAkt1 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9 , Ppp2ca , Serpine1
CHD family mediated chromatin remodeling pathwayHdac1
chemokine mediated signaling pathwayAkt1 , Gsk3b , Prkcd
chronic myeloid leukemia pathwayAbl1 , Akt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Hdac1 , Mdm2 , Tp53
cisplatin drug pathwayYbx1
coagulation cascade pathwaySerpine1
colorectal cancer pathwayAkt1 , Bax , Casp3 , Casp9 , Ccnd1 , Cycs , Cyct , Gsk3b , Mapk8 , Mapk9 , Tp53
complement system pathwaySerpine1
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayFas
dihydropyrimidinase deficiency pathwayRrm2 , Rrm2b
dilated cardiomyopathy pathwayIgf1
dopamine signaling pathwayCsnk1a1 , Ppp2ca
E-cadherin signaling pathwayAkt1 , Ccnd1 , Igf1
eicosanoid signaling pathwayAkt1 , Mapk14 , Prkcd
electron transport chain pathwayCycs
endocytosis pathwayMdm2
endometrial cancer pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
Endoplasmic Reticulum-associated degradation pathwayBax , Mapk8 , Mapk9 , Ube2d1
endothelin signaling pathwayAkt1 , Mapk14 , Mapk8 , Prkcd
Entamoebiasis pathwayCasp3
ephrin - ephrin receptor bidirectional signaling axisMapk8
epidermal growth factor/neuregulin signaling pathwayAbl1 , Akt1 , Cdkn1a , Gsk3b , Mapk8 , Mapk9
erythropoietin signaling pathwayMapk14 , Mapk8
estrogen signaling pathwayCrebbp , Ep300
extrinsic apoptotic pathwayCasp3 , Casp8 , Fas
FasL mediated signaling pathwayAkt1 , Bid , Casp3 , Casp8 , Fas , Mapk14 , Mapk8 , Mapk9
Fc epsilon receptor mediated signaling pathwayAkt1 , Mapk14 , Mapk8 , Mapk9 , Prkcd
Fc gamma receptor mediated signaling pathwayAkt1 , Prkcd
fibrinolysis pathwaySerpine1
fibroblast growth factor signaling pathwayAkt1
forkhead class A signaling pathwayAkt1 , Brca1 , Crebbp , Ep300
G1 phase pathwayCcnd1 , Cdk4
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcna2 , Ccnb1 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a
G2/M checkpoint pathwayCcnb1 , Cdk1
G2/M DNA damage checkpoint pathwayCcnb1 , Cdk1 , Chek1
G2/M DNA replication checkpoint pathwayCcnb1 , Cdk1
G2/M transition pathwayCcnb1 , Cdk1
gemcitabine pharmacodynamics pathwayRrm2 , Rrm2b
gemcitabine pharmacokinetics pathwayRrm2 , Rrm2b
glioma pathwayAkt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Igf1 , Mdm2 , Pten , Tp53
glutathione metabolic pathwayRrm2 , Rrm2b
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayMapk14 , Mapk8 , Mapk9 , Prkcd
graft-versus-host disease pathwayFas
Hedgehog signaling pathwayAkt1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Gsk3b , Hdac1 , Prkcd
hepatitis C pathwayAkt1 , Cdkn1a , Gsk3b , Mapk14 , Mapk8 , Mapk9 , Ppp2ca , Tp53
histone modification pathwayCrebbp , Daxx , Ep300 , Hdac1 , Kat2a , Kat2b , Kat5 , Kat8 , Prmt5 , Setd7 , Sirt1 , Smyd2
homocysteine metabolic pathwayPrmt5
homologous recombination pathway of double-strand break repairAtm , Brca1
Huntington's disease pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Hdac1 , Tp53
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayAkt1 , Crebbp , Ep300 , Serpine1
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Fas , Gsk3b , Mapk14 , Mapk8 , Mapk9
INO80 family mediated chromatin remodeling pathwayKat5 , Yy1 , Znhit1
inositol phosphate metabolic pathwayPten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Gsk3b , Sfn
insulin signaling pathwayAkt1 , Gsk3b , Mapk8 , Mapk9 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Igf1 , Igfbp3 , Prkcd
interleukin-1 signaling pathwayMapk8
interleukin-12 signaling pathwayGadd45b , Gadd45g , Mapk14
interleukin-2 signaling pathwayCdk2 , Mapk14 , Mapk8 , Mapk9
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwayAkt1 , Mapk14
interleukin-6 signaling pathwayAkt1 , Mapk14 , Prkcd
intrinsic apoptotic pathwayApaf1 , Bax , Bbc3 , Bid , Casp3 , Casp9 , Cycs , Fas , Pmaip1
iron uptake pathwaySteap3
Jak-Stat signaling pathwayAkt1 , Ccnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300
Kelley-Seegmiller syndrome pathwayRrm2
Leishmaniasis pathwayMapk14
Lesch-Nyhan syndrome pathwayRrm2
long term depressionGsk3b , Igf1 , Ppp2ca
long term potentiationCrebbp , Ep300
lysine degradation pathwaySetd7
measles pathwayAkt1 , Bbc3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Cdk2 , Cdk4 , Cdk6 , Fas , Gsk3b , Rchy1 , Tp53 , Tp73
melanoma pathwayAkt1 , Ccnd1 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Igf1 , Mdm2 , Pten , Tp53
mercaptopurine pharmacodynamics pathwayRrm2
methionine cycle/metabolic pathwayPrmt5 , Setd7 , Smyd2
mitochondrial neurogastrointestinal encephalopathy syndrome pathwayRrm2 , Rrm2b
mitogen activated protein kinase signaling pathwayAkt1 , Casp3 , Daxx , Fas , Gadd45a , Gadd45b , Gadd45g , Mapk14 , Mapk8 , Mapk9 , Tp53 , Tsc2
molybdenum cofactor deficiency pathwayRrm2
mRNA decay pathwayPpp2ca
mTOR signaling pathwayAkt1 , Ccne1 , Cdk2 , Cycs , Igf1 , Sfn , Tsc2 , Yy1
myocarditis pathwayAbl1 , Bid , Casp3 , Casp8 , Casp9 , Ccnd1 , Cycs , Cyct
N-cadherin signaling pathwayMapk8
neddylation pathwayNedd8
neurotrophic factor signaling pathwayAbl1 , Akt1 , Bax , Gsk3b , Mapk14 , Mapk8 , Mapk9 , Prkcd , Tp53 , Tp73
NOD-like receptor signaling pathwayCasp8 , Mapk14 , Mapk8 , Mapk9
non-small cell lung carcinoma pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Pten , Rassf1 , Tp53
Notch signaling pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Hdac1 , Kat2a , Kat2b , Skp2 , Yy1
nuclear factor kappa B signaling pathwayAtm , Mapk14
nuclear factor, erythroid 2 like 2 signaling pathwayBrca1 , Cdkn1a , Crebbp , Gsk3b , Pten
orotic aciduria 1 pathwayRrm2 , Rrm2b
oxygen homeostasis pathwaySerpine1
p38 MAPK signaling pathwayAtm , Gadd45a , Gadd45b , Gadd45g , Mapk14 , Ppm1d
p53 signaling pathwayAbl1 , Adgrb1 , Akt1 , Apaf1 , Atm , Bax , Bbc3 , Bid , Brca1 , Casp3 , Casp8 , Casp9 , Ccna2 , Ccnb1 , Ccnb2 , Ccnb3 , Ccnd1 , Ccnd2 , Ccnd3 , Ccne1 , Ccne2 , Ccng1 , Ccng2 , Cd82 , Cdk1 , Cdk2 , Cdk4 , Cdk6 , Cdkn1a , Cdkn2a , Chek1 , Chek2 , Cop1 , Crebbp , Cse1l , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Cycs , Cyct , Daxx , Dyrk2 , E4f1 , Ei24 , Ep300 , Fas , Fbxo11 , Gadd45a , Gadd45b , Gadd45g , Gsk3b , Gtse1 , Hdac1 , Hipk2 , Igf1 , Igfbp3 , Kat2a , Kat2b , Kat5 , Kat8 , Mapk14 , Mapk8 , Mapk9 , Mdm2 , Mdm4 , Muc1 , Nedd8 , Perp , Pin1 , Pmaip1 , Pou4f1 , Pou4f2 , Ppm1d , Ppp1r13b , Ppp1r13l , Ppp2ca , Prkcd , Prmt5 , Pten , Ptpa , Rassf1 , Rchy1 , Rpl11 , Rpl23 , Rpl5l1 , Rprm , Rrm2 , Rrm2b , Serpinb5 , Serpine1 , Sesn1 , Sesn3 , Setd7 , Sfn , Shisa5 , Siah1 , Sirt1 , Skp2 , Smyd2 , Steap3 , Tp53 , Tp53bp2 , Tp73 , Trim28 , Tsc2 , Ttc5 , Ube2d1 , Usp7 , Ybx1 , Yy1 , Zfp385a , Zfp420 , Zmat3 , Znhit1
p53-dependent G1/S DNA damage checkpoint pathwayCcne1 , Tp53
pancreatic cancer pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
Parkinson's disease pathwayApaf1 , Casp3 , Casp9 , Cycs , Cyct
phosphatidylinositol 3-kinase class I signaling pathwayPten
phosphatidylinositol 3-kinase signaling pathwayPten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Casp9 , Cdkn1a , Gsk3b , Ppp2ca , Pten , Sfn
phosphoinositide metabolic pathwayPten
platelet-derived growth factor signaling pathwayAbl1 , Mapk8 , Mapk9 , Pin1 , Ppp2ca , Prkcd , Pten , Sfn
prion disease pathwayBax
prostate cancer pathwayAkt1 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Crebbp , Ep300 , Gsk3b , Igf1 , Mdm2 , Pten , Tp53
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesNedd8
protein kinase C (PKC) signaling pathwayPrkcd
purine metabolic pathwayRrm2 , Rrm2b
purine nucleoside phosphorylase deficiency pathwayRrm2
pyrimidine metabolic pathwayRrm2 , Rrm2b
Ras mediated signaling pathwayTp73
Reelin signaling pathwayAkt1 , Gsk3b , Mapk8
renal cell carcinoma pathwayAkt1 , Crebbp , Ep300
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Mapk14 , Mapk8 , Mapk9 , Pin1
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
ribosome biogenesis pathwayCsnk1d , Csnk1e , Rpl11 , Rpl23
RNA polymerase I transcription pathwayCrebbp , Sirt1
RNA polymerase II transcription initiation pathwayKat2a , Kat2b
RNA transport pathwayPrmt5
S phase pathwayCcnd1 , Cdk4
Sirtuin mediated pathwaySirt1
sleeping sickness pathwayFas
small cell lung carcinoma pathwayAkt1 , Apaf1 , Casp9 , Ccnd1 , Ccne1 , Ccne2 , Cdk2 , Cdk4 , Cdk6 , Cycs , Cyct , Pten , Skp2 , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk14 , Mapk8
syndecan signaling pathwayBax , Casp3 , Mapk8 , Prkcd
T cell receptor signaling pathwayAkt1 , Cdk4 , Gsk3b , Mapk14 , Mapk9
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd , Tsc2
thyroid cancer pathwayCcnd1 , Tp53
tioguanine pharmacodynamics pathwayRrm2
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Fas , Tp53
Toll-like receptor signaling pathwayAkt1 , Casp8 , Mapk14 , Mapk8 , Mapk9
toxoplasmosis pathwayAkt1 , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Mapk14 , Mapk8 , Mapk9
Trail mediated signaling pathwayBid , Casp3 , Casp8 , Mapk8
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx , Ppp2ca
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Ppp2ca
translation pathwayRpl11 , Rpl23
tuberculosis pathwayAkt1 , Apaf1 , Bax , Bid , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Mapk14 , Mapk8 , Mapk9
tumor necrosis factor mediated signaling pathwayCasp8
type 1 diabetes mellitus pathwayFas
type 2 diabetes mellitus pathwayMapk8 , Mapk9 , Prkcd
type II interferon signaling pathwayAkt1 , Crebbp , Ep300 , Prkcd
ubiquitin/proteasome degradation pathwayBrca1 , Cop1 , Mdm2 , Rchy1 , Siah1 , Skp2 , Ube2d1
urinary bladder cancer pathwayCcnd1 , Cdk4 , Cdkn1a , Cdkn2a , Mdm2 , Rassf1 , Tp53
vascular endothelial growth factor signaling pathwayAkt1 , Casp9 , Mapk14 , Prkcd
vinblastine pharmacodynamics pathwayCdkn1a , Tp53
vincristine pharmacodynamics pathwayCdkn1a , Tp53
vindesine pharmacodynamics pathwayCdkn1a , Tp53
vinorelbine pharmacodynamics pathwayCdkn1a , Tp53
Wnt signaling pathwayCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Csnk1a1 , Csnk1e , Ep300 , Gsk3b , Mapk8 , Mapk9 , Ppp2ca , Siah1 , Tp53
Wnt signaling, canonical pathwayCrebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Tsc2
Wnt signaling, non-canonical pathwayCsnk1a1 , Mapk8 , Mapk9
xanthinuria type I pathwayRrm2
xanthinuria pathwayRrm2
xanthinuria type II pathwayRrm2
Phenotype Annotations Associated with Genes in the p53 signaling pathway

References Associated with the p53 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: