NON-SMALL CELL LUNG CANCER PATHWAY (PW:0000705)

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Description

Lung cancer, a major cause of cancer mortality, has been assigned to two types: small-cell (SCLC) and non-small cell lung cancer (NSCLC). The first, an extremely aggressive form of cancer accounts for ~20% of cases while the second accounts for the remaining ~80%. NSCLC itself is comprised of three subtypes: squamous- and large-cell carcinoma and adenocarcinoma. Of the three, the most prevalent type is adenocarcinoma. Well documented contributors to NSCLC are mutations in the epidermal growth f

Pathway Diagram:

Elsevier Inc. Lung Neoplasms cisplatin_DNA_adducts cisplatin drug pathway Map2k1 Braf Kras Egfr Erbb2 Pten Akt1 altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Pik3ca cisplatin_DNA_adducts ---| Lung Neoplasms cisplatin drug pathway ---> cisplatin_DNA_adducts Met gefitinib drug pathway ---> Egfr altered scatter factor/hepatocyte growth factor signaling pathway ---> altered epidermal growth factor/neuregulin signaling pathway gefitinib drug pathway potential NSCLC miRNA ---> Lung Neoplasms deregulated miRNA ---> deregulated target translation deregulated target translation deregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway altered regulation of target genes altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes Tp53 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway altered p53 signaling pathway potential NSCLC miRNA
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Genes in Pathway:

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non-small cell lung carcinoma pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5133243
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:5133242
RGD:6907045
RGD:5133243
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:6907045
RGD:5133242
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:5133243
RGD:6907045
G Fhit fragile histidine triad JBrowse link 15 15,697,292 16,862,873 RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5133242
RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:6907045
RGD:5133243
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241
RGD:5133243
RGD:5133242
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:5133242
RGD:6907045
RGD:5133243
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5133242
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6907045
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:6907045
G Rassf5 Ras association domain family member 5 JBrowse link 13 47,956,754 48,022,333 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6907045
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:6907045
G Rxrg retinoid X receptor gamma JBrowse link 13 85,818,473 85,868,555 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Stk4 serine/threonine kinase 4 JBrowse link 3 160,467,552 160,546,540 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5133242
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathwayA phosphatidylinositol 3-kinase-Akt signaling pathway that deviates from what its normal course should be
Pathwaycisplatin drug pathwayA platinum (Pt)-containing drug
Pathwayaltered extracellular signal-regulated pathwayA Raf/Mek/Erk signaling pathway that deviates from what its normal course should be. Aberrant Raf/Mek/Erk signaling has been implicated in many types of cancer.
Pathwayaltered scatter factor/hepatocyte growth factor signaling pathwayA scatter factor/hepatocyte growth factor signaling pathway that deviates from what its normal course should be
Pathwayaltered p53 signaling pathwayaltered p53 signaling pathway
Pathwayaltered epidermal growth factor/neuregulin signaling pathwayAn epidermal growth factor/neuregulin signaling pathway that deviates from what its normal course should be.
Functional Classpotential NSCLC miRNAderegulated miRNA that could serve as early detection markers
Pathwaygefitnib drug pathwayThe pharmacokinetics and pharmacodynamics pathway of gefitinib, a selective inhibitor of Egfr

Pathway Gene Annotations

Disease Annotations Associated with Genes in the non-small cell lung cancer pathway
Disease TermsGene Symbols
Aberrant Crypt FociMapk1 , Mapk3
acute kidney failureBad , Egf , Egfr , Met , Rb1 , Tgfa , Tp53
Acute Liver FailureCasp9 , Met
Acute Lung InjuryEgfr
acute lymphocytic leukemiaPten
acute myeloid leukemiaCcnd1 , Cdk6 , Cdkn2a , Hras , Kras , Met , Nras , Tp53
acute promyelocytic leukemiaAkt1 , Nras
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCcnd1 , Egf , Egfr , Erbb2 , Kras , Met , Pik3ca , Pten , Rarb , Rassf1 , Tp53
adenoid cystic carcinomaCcnd1 , Foxo3 , Hras , Kras , Map2k2 , Pik3ca , Pten , Tp53
adenomaKras , Tp53
adrenal carcinomaBraf , Nras , Pik3ca , Tp53
Adrenal Gland NeoplasmsRb1 , Tp53
adrenocortical carcinomaBraf , Egfr , Nras , Pik3ca , Rb1 , Tp53
adult T-cell leukemiaNras , Plcg1 , Prkcb , Tp53
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS-Associated NephropathyEgf
alcoholic cardiomyopathyRxra
Alzheimer's diseaseAkt1 , Bad , Casp9 , E2f1 , Egf , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Pik3r1 , Plcg1 , Plcg2 , Prkcb , Tp53
ameloblastomaBraf
amphetamine abuseAkt1 , Fhit
amyotrophic lateral sclerosisAkt1 , Bad , Casp9 , Tp53
amyotrophic lateral sclerosis type 1Rxra
Anaplastic Thyroid CarcinomaTp53
anemiaCdk6 , Kras
angiomyolipomaPten
angiosarcomaCcnd1 , Hras , Kras , Plcg1 , Tp53
Animal Disease ModelsAkt1 , Erbb2 , Kras , Mapk1 , Mapk3 , Prkcg , Tp53
Animal HepatitisMet
Animal Mammary NeoplasmsCcnd1 , Cdk4 , Egfr , Erbb2 , Hras , Pik3r1 , Rassf1 , Rb1 , Tgfa
anisometropiaPten
aortic valve diseaseEgfr
aortic valve stenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arsenic PoisoningTp53
arteriosclerosisMet
arteriovenous malformations of the brainEgfr , Kras
asbestos-related lung carcinomaRarb
asthmaEgfr , Pten
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Hras , Kras , Met , Tp53
AtaxiaPten
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1
atrial fibrillationCdk6
AtrophyMapk3
autism spectrum disorderMapk3
autistic disorderEgf , Hras , Mapk1 , Met , Prkcb , Pten
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
autosomal recessive Alport syndromeHras
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive nonsyndromic deafness 97Met
autosomal recessive polycystic kidney diseaseAkt1 , Egfr , Pik3ca
B-Cell Chronic Lymphocytic LeukemiaBraf , Hras , Kras , Nras , Plcg2 , Tp53
B-cell lymphomaNras
bacterial infectious diseaseCasp9
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePik3ca , Pten
Bardet-Biedl syndromeAkt3
basal cell carcinomaErbb2 , Pik3ca , Rb1 , Tp53
Bile Duct NeoplasmsEgfr , Met
biliary atresiaPten
bipolar disorderAkt1
bladder carcinomaHras
bladder diseaseRassf1
bladder urothelial carcinomaAkt1 , Braf , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pten , Tp53
bone development diseaseTp53
Bone Marrow NeoplasmsTp53
brain diseasePten
Brain InjuriesAkt1 , Bad
Brain Injuries, TraumaticBad
brain ischemiaAkt1 , Bad , Casp9 , Map2k1 , Mapk1 , Mapk3 , Prkca , Rb1 , Tp53
Brain NeoplasmsBraf , Ccnd1 , Cdk4 , Egfr , Hras , Nras , Pik3ca , Pik3r1 , Pten , Tp53
Brain Stem NeoplasmsCdk4 , Cdk6
breast adenocarcinomaAkt1 , Kras , Pik3ca , Tp53
breast cancerAkt1 , Braf , Erbb2 , Grb2 , Hras , Kras , Met , Pik3ca , Pten , Tp53
Breast Cancer, FamilialPik3ca , Pik3r3 , Tp53
Breast NeoplasmsAkt1 , Akt2 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Erbb2 , Fhit , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Met , Pdpk1 , Pik3ca , Pik3r1 , Plcg1 , Prkca , Pten , Raf1 , Rarb , Rassf1 , Rb1 , Rxrb , Tp53
bronchiolo-alveolar adenocarcinomaCcnd1 , Egfr , Kras , Tp53
Bronchopulmonary DysplasiaCasp9 , Tp53
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsBad , Ccnd1
Cafe au lait Spots, MultipleSos1
calcinosisErbb2
cancerBraf , Erbb2 , Hras , Nras , Pik3ca , Pik3r1 , Pten , Tp53
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf , Erbb2 , Kras
carcinomaCcnd1 , Cdk4 , Egfr , Fhit , Hras , Kras , Met , Pik3r1 , Pten , Rb1 , Tp53
cardiac arrestAkt1
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Mapk1 , Met , Prkca , Prkcb , Pten , Raf1 , Rb1
cardiomyopathyAkt1 , Kras , Mapk1 , Mapk3 , Tp53
CardiotoxicityTp53
Cardiovascular AbnormalitiesMap2k1
carotid artery diseaseTp53
Carotid Artery InjuriesFoxo3
cataractCasp9 , Map2k1 , Pten , Tp53
Cecal NeoplasmsCcnd1 , Kras , Tp53
Cell Transformation, NeoplasticCcnd1 , Egf , Hras , Kras , Pten , Tp53
Central Nervous System NeoplasmsTp53
cerebral cavernous malformationPten
Cerebral HemorrhageCasp9
cervical cancerTp53
cervix carcinomaTp53
cervix uteri carcinoma in situCcnd1 , Cdk4 , Cdkn2a , Pten , Rb1
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBad
Chemotherapy-Induced Febrile NeutropeniaTp53
childhood pilocytic astrocytomaMapk1
ChloracneCdk6 , Egfr
cholangiocarcinomaEgfr , Erbb2 , Kras , Met , Pten , Tp53
cholesteatoma of middle earTp53
choroid plexus carcinomaFoxo3 , Tp53
choroid plexus papillomaTp53
Chromosome 13q Deletion SyndromeRb1
chromosome 13q14 deletion syndromeRb1
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chronic HepatitisMet
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras , Plcg2 , Tp53
chronic myeloid leukemiaAkt1 , Braf , Cdkn2a , E2f1 , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseEgfr , Foxo3 , Tp53
Chronic PancreatitisBad
clear cell adenocarcinomaTp53
cleft palateEgf
CLOVES syndromePik3ca
Cocaine-Related DisordersMapk1 , Mapk3
cognitive disorderMet
Cognitive DysfunctionTp53
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3
colon cancerAkt1 , Braf , Nras , Pik3ca , Tp53
colon carcinomaAkt1 , Braf , Nras , Pik3ca , Tp53
Colonic NeoplasmsAkt2 , Akt3 , Bad , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Pten , Tp53
colorectal adenocarcinomaMapk1 , Mapk3 , Raf1 , Tp53
colorectal adenomaRaf1
colorectal cancerAkt1 , Braf , Nras , Pik3ca , Tp53
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Casp9 , Ccnd1 , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Prkcb , Pten , Raf1 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Pik3ca
congenital diaphragmatic herniaMet
congenital dyserythropoietic anemiaTp53
congenital heart diseaseRxra
congenital hypoplastic anemiaTp53
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureErbb2 , Pdpk1 , Prkca , Prkcb , Tp53
Copper-Overload CirrhosisMet
coronary artery diseaseAkt1
coronary restenosisMapk1 , Tp53
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cowden diseaseAkt1 , Egfr , Pik3ca , Pten
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca , Pten
Craniofacial AbnormalitiesEgfr , Pten , Tp53
craniopharyngiomaBraf
Cryopyrin-Associated Periodic SyndromesPlcg2
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Pten
Cutaneous Malignant Melanoma, Susceptibility To, 3Cdk4
cutaneous T cell lymphomaBraf , Cdkn2a , Plcg1 , Tp53
dementiaE2f1 , Egfr
demyelinating diseaseMapk1 , Tp53
dermatitisEgf , Egfr
dermoid cyst of ovaryFoxo3
developmental coordination disorderPten
Developmental DisabilitiesAkt3 , Braf , Pik3r2 , Pten
Diabetes ComplicationsCasp9
diabetes mellitusPten
Diabetes Mellitus, Experimental Akt1 , Bad , Casp9 , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Met , Pik3r1 , Plcg1 , Prkca , Prkcb , Tp53
Diabetic CardiomyopathiesBad , Casp9 , Erbb2 , Mapk1 , Mapk3
Diabetic CystopathyBad
Diabetic NephropathiesCasp9 , Egf , Mapk1 , Prkcb , Pten , Tp53
diabetic neuropathyBad
diabetic retinopathyCasp9 , Egfr , Hras
Diamond-Blackfan anemiaTp53
Diamond-Blackfan Anemia 6Tp53
Diaphragmatic HerniaRxra
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd , Tp53
dilated cardiomyopathyCasp9 , Egfr , Erbb2 , Kras , Prkca , Prkcb , Raf1 , Rxra , Tp53
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Erbb2 , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53
Disease ProgressionEgf , Egfr , Erbb2 , Hras , Pik3ca , Pten , Rxrb
Distal Arthrogryposis Multiplex Congenita, Type 1Met
Distal Arthrogryposis, Type 1AMet
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
ductal carcinoma in situCcnd1 , Erbb2 , Prkca , Rb1 , Tp53
dysembryoplastic neuroepithelial tumorBraf
dyskeratosis congenitaTp53
dysplastic nevus syndromeCdkn2a
EdemaCasp9
embryonal carcinomaRb1
EmphysemaTp53
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerEgf , Kras , Pik3cb , Pik3r1 , Pten , Tp53
endometrial carcinomaHras , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Pten
endometrial hyperplasiaKras , Pten
Endometrial NeoplasmsAkt2 , Bad , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egf , Erbb2 , Fhit , Foxo3 , Grb2 , Kras , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Prkca , Pten , Rassf1 , Rb1 , Tp53
Endometrioid CarcinomasAkt1 , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Pik3r2 , Pten
endometriosisEgfr , Kras , Rarb
endometritisCasp9
EndotoxemiaCasp9
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1
esophageal cancerTp53
esophageal carcinomaEgfr , Erbb2 , Hras , Kras , Pik3ca , Tp53
Esophageal NeoplasmsCcnd1 , Cdkn2a , Egfr , Erbb2 , Met , Tp53
esophagus adenocarcinomaPik3ca , Tp53
esophagus squamous cell carcinomaEgfr
Experimental ArthritisAkt1 , Cdkn2a , Egfr , Nras , Pik3cd
Experimental Autoimmune EncephalomyelitisCasp9 , Foxo3
Experimental Autoimmune MyocarditisCasp9
Experimental ColitisMapk1 , Mapk3
Experimental LeukemiaCdkn2a , Nras
Experimental Liver CirrhosisCdk4 , Egf , Mapk1 , Mapk3 , Met , Prkcb , Rxra
Experimental Liver NeoplasmsCcnd1 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Rb1 , Rxra , Tgfa , Tp53
Experimental NeoplasmsBraf , Ccnd1 , Cdk4 , Erbb2 , Hras , Kras , Nras , Rb1 , Tp53
Experimental SarcomaKras , Nras
extrahepatic cholestasisMapk1 , Mapk3
Facial AsymmetryPik3ca
familial adenomatous polyposisAkt1 , Egfr
familial cold autoinflammatory syndrome 3Plcg2
familial hypertrophic cardiomyopathyKras , Raf1 , Sos1
familial melanomaCdk4
familial meningiomaPten
familial partial lipodystrophyAkt2
Familial Prostate CancerMap2k1
fatty liver diseasePten
Female InfertilityMapk1 , Mapk3 , Tp53
fetal alcohol spectrum disorderPten
Fetal DiseasesPrkcb
Fetal MacrosomiaPten
fibrillary astrocytomaKras
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1
focal segmental glomerulosclerosisCasp9
Follicular Thyroid CancerBraf , Hras , Nras , Pten
follicular thyroid carcinomaBraf , Hras , Kras , Nras , Pten
Funnel ChestTp53
gallbladder carcinomaErbb2 , Pik3ca , Tp53
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Kras , Met , Tgfa , Tp53
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pten , Raf1 , Tp53
gastric ulcerBad , Egf , Mapk1 , Mapk3
gastrinomaMet
gastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten
gastrointestinal stromal tumorBraf , Kras , Rb1
Gaucher's diseaseTp53
Gaucher's disease type ITp53
genetic diseaseAkt2 , Akt3 , Braf , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Pik3ca , Pik3r1 , Pik3r2 , Plcg2 , Prkcg , Pten , Raf1 , Rarb , Sos1
Genetic Predisposition to DiseaseEgf , Tgfa
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsCdk4 , Cdkn2a , Erbb2 , Fhit
germinomaBraf , Cdkn2a
gestational diabetesMet
Giant Pigmented Hairy NevusHras , Nras
Gilles de la Tourette syndromeMet
gingival fibromatosisSos1
glaucomaBad
glioblastoma multiformeAkt1 , Akt3 , Braf , Cdk4 , Cdk6 , Cdkn2a , E2f1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k2 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pten , Rb1 , Tp53
glioblastoma proneural subtypeRb1
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
grade III astrocytomaKras , Tp53
Graft vs Host DiseaseTp53
granulosa cell tumorCdkn2a , Fhit
Graves' diseaseTp53
Growth DisordersPik3ca
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsEgfr , Mapk1 , Mapk3 , Pik3ca , Rarb , Tgfa , Tp53
head and neck squamous cell carcinomaAkt1 , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Pten , Tp53
heart diseaseCasp9
HELLP syndromeErbb2
hemangiomaPten
HemimegalencephalyPik3ca
hepatoblastomaTgfa , Tp53
hepatocellular adenomaHras , Kras , Pten
hepatocellular carcinomaAkt1 , Akt2 , Braf , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Fhit , Hras , Kras , Met , Nras , Pik3ca , Pten , Rb1 , Rxra , Tgfa , Tp53
HepatomegalyPten
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeTp53
Hereditary Neoplastic SyndromesCdk4 , Egfr , Met , Pik3ca , Pten , Rb1 , Tp53
Hereditary PancreatitisCasp9
hereditary renal cell carcinomaEgf
hereditary spastic paraplegia 11Tp53
Hirschsprung's diseaseErbb2
Huntington's diseaseCasp9 , E2f1 , Egfr
HyperalgesiaMapk1 , Mapk3 , Prkcb , Prkcg , Raf1
HypercholesterolemiaCasp9
hyperglycemiaPrkcb
hyperinsulinismPten
HyperoxiaCdk4
HyperparathyroidismCcnd1
HyperplasiaAkt1 , Ccnd1 , Cdkn2a , Egfr , Pik3ca
hypertensionAkt1 , Akt2 , Bad , Casp9 , Cdkn2a , Egfr , Kras , Pik3r1 , Prkca , Prkcb , Pten , Tp53
hypertrophic cardiomyopathyRaf1 , Rassf1 , Tp53
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3 , Pten
hypoglycemiaAkt2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypothyroidismBad
hypotrichosis 8Rb1
Hypoxia-Ischemia, BrainCasp9 , Foxo3
Immediate HypersensitivityEgfr
immune system diseasePrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
impotenceAkt1 , Bad , Ccnd1
in situ carcinomaAkt1 , Cdkn2a , Pten , Rb1
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaEgf
InflammationAkt1 , Egfr , Tgfa
inflammatory bowel diseasePlcg2 , Rassf1
Insulin ResistanceAkt2 , Bad , Egfr , Mapk3 , Pik3r1 , Prkcb , Pten , Rb1
insulinomaTgfa
intellectual disabilityKras , Prkcg , Pten , Rb1
intermediate coronary syndromeAkt1
intermittent claudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsMap2k1 , Map2k2 , Prkca
Intestinal PolypsCcnd1
intestinal pseudo-obstructionPten , Rb1
Intestinal Reperfusion InjuryCasp9
Intimal HyperplasiaFoxo3
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Cdkn2a , Erbb2 , Fhit
invasive lobular carcinomaCcnd1 , Erbb2
ischemiaAkt2 , Prkca , Raf1 , Tp53
juvenile myelomonocytic leukemiaKras , Nras
juvenile polyposis syndromePten
juvenile rheumatoid arthritisEgf , Kras , Mapk1
Kaposi's sarcomaTp53
keratosisTp53
kidney diseaseCasp9 , Egf , Mapk1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Raf1 , Rassf1 , Rassf5
Klinefelter's syndromeNras
Knee OsteoarthritisTgfa
L-2-hydroxyglutaric aciduriaSos2
Langerhans-cell histiocytosisBraf
Language Development DisordersPten
large cell carcinomaMet , Prkca
Laryngeal NeoplasmsEgfr
Leber hereditary optic neuropathyTp53
Left Ventricular HypertrophyEgfr , Foxo3 , Prkca , Prkcb , Pten
leiomyomaPten
leiomyosarcomaCdkn2a
LEOPARD syndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaBad , Ccnd1 , Cdkn2a , Nras , Pten , Tp53
LeukocytosisKras , Nras
Leydig cell tumorCdk4
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 1Tp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lip NeoplasmsTp53
lipomaPten
lipomatosisPten
liposarcomaCdk4
Lipoyltransferase 1 DeficiencyTp53
liver benign neoplasmBraf , Ccnd1 , Fhit , Hras , Kras , Met , Raf1 , Tgfa , Tp53
liver cancerAkt1 , Hras , Kras , Nras , Pik3ca , Tp53
liver cirrhosisCasp9
Liver Reperfusion InjuryBad , Casp9
long QT syndromeE2f1 , Pten
low tension glaucomaTp53
lung adenocarcinomaAkt1 , Braf , Ccnd1 , Cdk4 , Cdk6 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Raf1 , Rarb , Sos1 , Tp53
lung cancerBraf , Egfr , Erbb2 , Kras , Pik3ca , Rassf1
lung diseaseEgfr
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pten , Raf1 , Rarb , Rassf1 , Tp53
lung small cell carcinomaAkt1 , Ccnd1 , E2f1 , Egfr , Pik3ca , Pik3r1 , Pten , Rarb , Rb1 , Tp53
lung squamous cell carcinomaAkt1 , Braf , Ccnd1 , Cdk4 , E2f1 , E2f3 , Egfr , Hras , Kras , Pik3ca , Pten , Tp53
lupus nephritisEgf
LymphangiectasisRaf1
Lymphatic MetastasisCasp9 , Egfr , Erbb2 , Pdpk1 , Pik3ca , Pik3cb , Pten , Tp53
lymphedemaMet
lymphomaKras , Nras , Pten , Tp53
MacrocephalyAkt3 , Pten
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3 , Pten
macular degenerationBad
male infertilityTp53
malignant gliomaAkt2 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk3 , Met , Pik3ca , Pik3r3 , Prkca , Pten , Raf1 , Rassf1 , Tp53
malignant mesotheliomaCdk6 , Egfr , Met , Raf1 , Rxra , Tp53
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Hras , Mapk1 , Mapk3 , Pik3r1 , Pten , Rb1 , Rxra , Tgfa , Tp53
mammary Paget's diseaseErbb2
Mandibular NeoplasmsBraf
mantle cell lymphomaCcnd1 , Pik3cd
marginal zone B-cell lymphomaTp53
median neuropathyErbb2
medulloblastomaCcnd1 , Cdk6 , Erbb2 , Foxo3 , Nras , Pik3ca , Rassf1 , Rb1 , Tp53
Megakaryoblastic Leukemia of Down SyndromeNras , Tp53
megakaryocytic leukemiaPten , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Braf , Cdk4 , Cdkn2a , E2f1 , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3r1 , Pten , Raf1 , Tp53
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pten
MesotheliomaEgfr , Fhit , Rassf1 , Tp53
MetaplasiaEgf
Micronuclei, Chromosome-DefectiveRassf1
Microphthalmia, Syndromic 12Rarb
Microsatellite InstabilityBraf
middle cerebral artery infarctionBad , Casp9 , Mapk1 , Mapk3 , Prkcg
migraineMap2k2
Mixed Tumor, MullerianCdkn2a
Mouth NeoplasmsErbb2 , Hras , Kras , Nras , Pik3ca , Pten , Tp53
mucositisTgfa
Muir-Torre syndromeFhit
Multiple AbnormalitiesKras , Mapk1 , Pik3r2 , Pten
Multiple Hamartoma SyndromePik3ca , Pten
multiple myelomaBraf , Ccnd1 , Cdk4 , Cdkn2a , Hras , Kras , Met , Nras , Pik3ca , Tp53
Multiple Organ FailureMapk1
muscular atrophyAkt1
muscular dystrophyPten
myelodysplastic syndromeCdkn2a , Hras , Kras , Nras , Tp53
myelofibrosisTp53
myeloid neoplasmKras , Nras
myeloid sarcomaKras
myocardial infarctionAkt1 , Mapk1 , Tp53
Myocardial IschemiaCcnd1 , Erbb2 , Rxrg
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Mapk1 , Mapk3 , Prkcb , Pten , Tp53
Nasal PolypsMet
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Hras , Nras , Pik3ca , Tp53
nasopharynx carcinomaTp53
Nematode InfectionsPik3r1
Neonatal Inflammatory Skin and Bowel Disease 2Egfr
Neoplasm InvasivenessEgf , Egfr , Hras , Mapk1 , Mapk3 , Met , Pten
Neoplasm MetastasisAkt2 , Braf , Ccnd1 , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r3 , Pten , Rb1 , Rxra , Tp53
Neoplasm Recurrence, LocalEgfr , Erbb2
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplastic ProcessesHras
nephroblastomaCdk4 , Cdkn2a , Erbb2 , Tp53
nephrogenic diabetes insipidusPrkca
Nerve DegenerationMapk1 , Mapk3 , Tgfa
Nerve Sheath NeoplasmsMet , Pten , Tp53
nervous system diseaseCasp9 , Tp53
neurilemmomaCdkn2a
neuroblastomaCdkn2a , Hras , Kras , Met , Nras , Pik3ca , Rassf1 , Rassf5 , Tp53
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersPten
neuroendocrine tumorBraf
neurofibrosarcomaNras
Neurogenic InflammationRxra
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
NevusBraf
Nevus, PigmentedNras
non-functioning pancreatic endocrine tumorCdk4 , Cdk6
non-Hodgkin lymphomaBraf , Ccnd1 , Map2k1 , Nras , Pik3ca , Tp53
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fhit , Foxo3 , Hras , Kras , Map2k1 , Met , Nras , Pdpk1 , Pik3ca , Prkcb , Pten , Raf1 , Rarb , Rassf1 , Rassf5 , Rb1 , Rxrg , Tgfa , Tp53
nonalcoholic fatty liver diseasePrkca
Nonseminomatous Germ Cell TumorBraf
nonsyndromic deafnessMet , Tgfa
Noonan Like SyndromeSos1
Noonan syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras , Raf1
Noonan syndrome 3Hras , Kras , Raf1 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
Nose NeoplasmsTp53
NSAID-EnteropathyCasp9
obesityAkt1 , Akt2 , Bad , Cdk4 , Cdkn2a , Egfr , Foxo3 , Mapk1 , Mapk3 , Pik3r1 , Prkcb , Rb1 , Rxra
obsessive-compulsive disorderHras
Occupational AsthmaPrkca
Odontogenic MyxomaTp53
oligodendrogliomaEgf , Rb1
Oral Lichen PlanusTp53
oral mucosa leukoplakiaTp53
oral squamous cell carcinomaMet , Plcg1
oral submucous fibrosisTp53
Oropharyngeal NeoplasmsTp53
osteoarthritisBad , Casp9 , Cdkn2a
Osteoarthritis, ExperimentalMapk3
osteochondrodysplasiaPten
Osteofibrous DysplasiaMet
osteosarcomaAkt1 , Egfr , Met , Rb1 , Tp53
ovarian cancerAkt1 , Egf , Erbb2 , Kras , Pik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r1 , Prkca , Pten , Rassf1 , Rb1 , Tp53
ovarian serous cystadenocarcinomaBraf , Erbb2 , Hras , Nras , Pik3ca , Tp53
ovary adenocarcinomaErbb2
PainAkt1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaCcnd1 , Cdk4 , Cdk6 , E2f1 , Erbb2 , Hras , Kras , Map2k2 , Pik3ca , Rxra , Tp53
pancreatic cancerAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Egf , Egfr , Kras , Met , Pten , Rb1 , Rxra , Tgfa , Tp53
pancreatic carcinomaCdkn2a , Kras , Tp53
pancreatic ductal adenocarcinomaCcnd1 , Cdk4
pancreatic ductal carcinomaCcnd1 , Cdk6 , E2f1 , Egf , Kras , Met , Rxra
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1
Pancreatic Islet Cell TumorsCdk4
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisEgf , Met
Pancreatitis, Experimental, Acute Kras
pancytopeniaTp53
papillary renal cell carcinomaBraf , Erbb2 , Hras , Met , Nras , Pik3ca , Pten , Tp53
papillary thyroid carcinomaBraf , Ccnd1 , Rxrg
papillomaCcnd1 , Egfr , Erbb2 , Hras , Tgfa
Papillomavirus InfectionsCdkn2a
paranasal sinus neoplasmTp53
paraplegiaAkt1
Parasitic Liver DiseasesKras , Tp53
Parkinson's diseaseAkt1 , Casp9 , Egf , Egfr , Erbb2
Parkinsonian DisordersBad , Casp9 , Egfr
Pediatric Adrenocortical CarcinomaTp53
penile neoplasmCcnd1 , Hras , Kras , Pik3ca , Tp53
peptic esophagitisEgfr
perinatal necrotizing enterocolitisEgf
periodontitisMet
peripheral nervous system diseaseCasp9
peripheral nervous system neoplasmPten
persistent fetal circulation syndromePten
persistent hyperplastic primary vitreousCdkn2a
phobic disorderHras
Phyllodes TumorEgfr , Rb1 , Tp53
pilocytic astrocytomaKras
Pituitary NeoplasmsPrkca , Rb1
plasmacytomaBraf , Cdk4 , Cdkn2a , Hras , Kras , Nras , Pik3ca , Tp53
pleomorphic xanthoastrocytomaBraf , Cdk6 , Egfr , Met , Tp53
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaEgf
polycystic kidney diseasePlcg1
polycystic ovary syndromeAkt2
polydactylyPten
PolymicrogyriaAkt3
PolyploidyTp53
PolyuriaPrkca
portal hypertensionPik3r1 , Pten
post-traumatic stress disorderCasp9
pre-eclampsiaErbb2
pre-malignant neoplasmAkt1 , Casp9 , Ccnd1 , Cdkn2a , Egf , Hras , Tp53
precursor B lymphoblastic lymphoma/leukemiaCcnd1 , Cdkn2a , Tp53
precursor lymphoblastic lymphoma/leukemiaCcnd1 , Cdk6 , Cdkn2a , Kras , Nras , Rb1 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaCdkn2a , Kras
Premature AgingCdkn2a , Tp53
primary autosomal recessive microcephaly 12Cdk6
primary hypomagnesemiaEgf
primary open angle glaucomaTp53
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Erbb2 , Grb2 , Hras , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Pten , Raf1 , Tp53
prostate cancerAkt2 , Akt3 , E2f1 , E2f3 , Erbb2 , Grb2 , Kras , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pten , Raf1 , Sos1 , Tp53
Prostate Cancer, SomaticPten
prostate carcinomaAkt2
prostate carcinoma in situCcnd1 , Kras , Pten , Rxra
prostatic hypertrophyBad , Cdk4 , Pten
Prostatic NeoplasmsAkt1 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Egf , Egfr , Erbb2 , Fhit , Foxo3 , Hras , Kras , Map2k1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkca , Pten , Rassf1 , Rb1 , Rxra , Tgfa , Tp53
Proteus syndromeAkt1 , Pten
psoriasisTgfa , Tp53
PTEN hamartoma tumor syndromePik3ca , Pten
pterygiumTp53
pulmonary edemaTgfa
pulmonary fibrosisBad , Egf , Egfr , Tgfa
pulmonary hypertensionEgfr , Mapk1 , Mapk3 , Tgfa , Tp53
pulmonary valve stenosisBraf , Hras , Sos1
Radiation Injuries, ExperimentalCasp9 , Mapk1 , Mapk3
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
rectal neoplasmEgfr , Nras , Pik3ca , Pik3cb
RecurrenceErbb2 , Hras , Kras
renal carcinomaMet , Nras , Pik3ca , Pten , Tp53
renal cell carcinomaAkt1 , Akt3 , Bad , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Kras , Map2k1 , Mapk1 , Met , Nras , Pik3ca , Pik3r1 , Pten , Rassf1 , Rb1 , Tp53
renal fibrosisKras , Mapk1
renal hypomagnesemia 3Egf
renal hypomagnesemia 4Egf
renal hypomagnesemia 5 with ocular involvementEgf
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Egf , Met , Pik3r1 , Prkca , Pten , Tp53
Retina Reperfusion InjuryBad
retinal detachmentCasp9
retinitis pigmentosaPrkcg , Pten
retinoblastomaRb1
rhabdomyosarcomaCdkn2a , Tp53
rheumatoid arthritisCdk6 , Foxo3
Right Ventricular HypertrophyAkt1 , Prkca , Tgfa
Salivary Gland NeoplasmsCcnd1
sarcomaMet , Pik3ca , Tp53
sarcomatoid mesotheliomaCdkn2a
schistosomiasisRassf1
schizophreniaAkt1 , Egf , Egfr , Mapk3 , Met , Pik3cb , Tp53
sciatic neuropathyRarb , Rxra
scrapieCasp9
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
seminomaFhit , Hras , Kras , Rb1
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossPrkcb
SepsisBad , Casp9 , Mapk1 , Mapk3 , Rxra
Septic PeritonitisPik3r1
serous cystadenocarcinomaTp53
Sezary's diseaseBraf , Mapk1 , Plcg1 , Pten , Rb1 , Tp53
ShockMapk1 , Mapk3
Shock, HemorrhagicBad , Mapk1
SHORT SyndromePik3r1
silicosisPrkcb
sinusitisMet
Sjogren's syndromeE2f1
skin benign neoplasmHras
skin diseasePten
skin melanomaAkt1 , Braf , Cdk4 , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Pten , Raf1
Skin NeoplasmsAkt1 , Hras , Tp53
small cell carcinomaRassf1 , Rb1 , Tp53
Small-For-Size SyndromeBad
Smith-Magenis syndromeErbb2 , Grb2 , Map2k2 , Prkca
spermatocytomaHras
Spinal Cord InjuriesAkt1 , Casp9 , Egfr , Foxo3 , Met , Tp53
Spinal Cord Reperfusion InjuryBad
spinocerebellar ataxia type 14Prkcg
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Erbb2 , Hras , Pik3ca , Tp53
squamous cell carcinomaAkt1 , Ccnd1 , Cdkn2a , Egfr , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Rarb , Tp53
status epilepticusCcnd1 , Foxo3 , Prkcb
Stevens-Johnson syndromeRb1
stomach cancerErbb2 , Kras , Pik3ca
stomach carcinomaKras
stomach diseasePten
Stomach NeoplasmsCcnd1 , Cdk4 , Egfr , Erbb2 , Fhit , Hras , Kras , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Prkcb , Rarb , Rxrb , Tgfa , Tp53
StrokeAkt1 , Cdk6 , Pik3ca , Tgfa
Subarachnoid HemorrhageCasp9
substance-induced psychosisAkt1
substance-related disorderFhit , Pten
systemic lupus erythematosusRassf5 , Rxra
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac MalformationsStk4
T-cell leukemiaCdkn2a
T-Cell LymphomaAkt1 , Tp53
temporal lobe epilepsyFoxo3
Testis Reperfusion InjuryCasp9 , Mapk1 , Mapk3
third ventricle chordoid gliomaPrkca
thrombosisPik3cb
thymomaHras , Tp53
Thymus NeoplasmsTp53
thyroid cancerMapk1
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Hras , Kras , Nras , Pik3ca , Pten , Rxra , Tp53
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn2a , Hras , Tp53
tongue squamous cell carcinomaEgfr , Met , Tp53
transient cerebral ischemiaBad , Casp9 , Cdkn2a , Pten
transitional cell carcinomaAkt1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Nras , Pik3ca , Pten , Rassf1 , Rxra , Tp53
Trichilemmoma Hras
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaMapk1 , Mapk3 , Prkcg
trilateral retinoblastomaRb1
Tumor Predisposition SyndromeCdk4 , Met , Pten , Tp53
type 1 diabetes mellitusCasp9 , Cdk4 , E2f1 , Egfr
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Braf , Casp9 , Cdk4 , Egfr , Mapk1 , Mapk3 , Pik3cb , Pik3r1 , Prkcb
UnconsciousnessPten
ureteral obstructionAkt1 , Casp9 , Mapk1 , Mapk3
urethral obstructionMapk1
urinary bladder cancerAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egfr , Erbb2 , Fhit , Hras , Kras , Prkca , Pten , Rassf1 , Rb1 , Tp53
Urinary Bladder NeoplasmHras , Kras , Rb1
Urinary IncontinenceMapk1
Urogenital NeoplasmsTp53
Urologic NeoplasmsCcnd1 , Erbb2 , Fhit , Tp53
uterine carcinosarcomaErbb2 , Hras , Pik3ca , Pik3r1 , Pten , Tp53
Uterine Cervical NeoplasmsAkt1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Fhit , Hras , Kras , Mapk1 , Nras , Pik3ca , Pten , Rarb , Rassf1 , Sos1 , Tp53
Uterine NeoplasmsBraf , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Pten , Sos1 , Tp53
VACTERL associationPten
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9
vascular dementiaTp53
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1
ventricular septal defectBraf
Ventricular TachycardiaRaf1
viral encephalitisE2f1
visual epilepsyBad , Ccnd1 , Pik3ca , Pten
vitiligoPik3r1
von Hippel-Lindau diseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsCdkn2a , Fhit , Tp53
Wallerian DegenerationErbb2 , Rxra
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
withdrawal disorderMapk1 , Mapk3
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf
xeroderma pigmentosumTp53
Zollinger-Ellison syndromeEgf
Pathway Annotations Associated with Genes in the non-small cell lung cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
adenosine signaling pathwayAkt1 , Bad , Braf , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
Alzheimer's disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Prkcb , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayTp53
bile acid transport pathwayRxra
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Tgfa , Tp53
cetuximab pharmacodynamics pathwayEgfr
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cytokine mediated signaling pathwayEgf , Egfr , Met
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Egf , Egfr , Pik3ca , Pik3r1 , Plcg1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Prkca , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1 , Rxra , Rxrb , Rxrg
endocytosis pathwayEgf , Egfr , Hras , Met
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Prkcg , Raf1
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Plcg1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Plcg1 , Plcg2 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcg , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
fibroblast growth factor signaling pathwayAkt1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Plcg1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Prkca , Prkcb , Prkcg
gonadotropin-releasing hormone signaling pathwayEgfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rxra , Sos1 , Sos2 , Tp53
Huntington's disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Plcg1 , Plcg2 , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Prkcb , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmaniasis pathwayMapk1 , Mapk3 , Prkcb
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1
malaria pathwayMet
measles pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Prkcb , Prkcg , Raf1 , Sos1 , Sos2 , Stk4 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Plcg1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fhit , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten , Raf1 , Rarb , Rassf1 , Rassf5 , Rb1 , Rxra , Rxrb , Rxrg , Sos1 , Sos2 , Stk4 , Tgfa , Tp53
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayPten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Pten , Rassf1 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson's disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Prkca , Pten , Raf1 , Sos1
prion disease pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
protein kinase C (PKC) signaling pathwayPdpk1 , Prkca , Prkcb , Prkcg
purine metabolic pathwayFhit
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
retinoic acid signaling pathwayRarb , Rxra , Rxrb , Rxrg
ribosome biogenesis pathwayPrkcb
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Met , Pik3r1 , Plcg1
sleeping sickness pathwayPrkca , Prkcb , Prkcg
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , E2f1 , E2f3 , Fhit , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rarb , Rb1 , Rxra , Rxrb , Rxrg , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Mapk1 , Mapk3 , Plcg1
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3 , Prkca
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdk4 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Rxra , Rxrb , Rxrg , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
trastuzumab pharmacodynamics pathwayEgfr
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
urinary bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rassf1 , Rb1 , Tp53
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayCcnd1 , Prkca , Prkcb , Prkcg , Tp53
Phenotype Annotations Associated with Genes in the non-small cell lung cancer pathway

References Associated with the non-small cell lung cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: