TRAIL MEDIATED SIGNALING PATHWAY (PW:0000682)

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Description

Trail mediated signaling is one of the major extrinsic apoptotic pathways engaging the death receptors. Trail, also known as Apo2L (official symbol Tnfsf10) and its receptors belong to the tumor necrosis superfamily (TNF) of ligands and receptors. Of the five receptors that can bind Tnfsf10, only two can induce apoptosis; they both contain the DD domain (death domain) in their cytoplasmic part while the extracellular part contains the CCG (...(more)

Pathway Diagram:

Ariadne Genomics Inc. caspase targets Bid Fadd Casp3 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp8 ---- Fadd Fadd ---- TNFRSF10A intrinsic apoptotic pathway Casp8 ---> Bid Fadd ---- Tnfrsf10b TNFRSF10A ---- Tnfsf10 Tnfrsf10b ---- Tnfsf10 TNFRSF10A Cflar ---- Fadd Casp8 ---> Casp3 Casp8 ---> Casp7 Casp7 ---> caspase targets Casp3 ---> caspase targets Casp7 Casp8 Cflar Tnfrsf10b Tnfsf10 Cflar ---| Casp8 Casp8 --+> Casp7 Casp8 --+> Casp3 Casp8 --+> Bid
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Genes in Pathway:

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Trail mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:4143170
RGD:4143171
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:4143170
RGD:4143171
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:4143171
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:4143170
RGD:6484113
RGD:4143171
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:4143170
RGD:6484113
RGD:4143171
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:6484113
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:4143170
RGD:6484113
RGD:4143171
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6484113
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6484113
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6484113
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:4142856
RGD:4143170
RGD:4143171
RGD:6484113
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:2312745
RGD:6484113
RGD:4143171
RGD:4143170
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupCaspase targetstargets for caspase

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Trail mediated signaling pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
abdominal aortic aneurysmMapk8
abdominal obesity-metabolic syndrome 1Fadd
Aberrant Crypt FociMapk1 , Mapk3
Abortion, SpontaneousTnfsf10
Acute Liver FailureCasp3 , Mapk8
Acute Lung InjuryCasp3 , Casp8 , Fadd
acute myeloid leukemiaCasp7 , Cflar , Fadd , Tnfsf10
acute myocardial infarctionCasp3 , Casp7
Acute Necrotizing PancreatitisCasp3
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCasp8 , Pik3ca , Tnfrsf10b
adenoid cystic carcinomaPik3ca
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Alcohol-Related DisordersCasp8
allergic contact dermatitisCasp8
alopeciaTnfrsf10b
Alzheimer's diseaseCasp3 , Casp7 , Casp8 , Fadd , Ikbkb , Mapk1 , Mapk3 , Mapk8 , Pik3r1
amyotrophic lateral sclerosisBid , Casp3
anemiaTnfrsf10b
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsMapk1 , Mapk3 , Mapk8
Animal Mammary NeoplasmsPik3r1
AnorexiaTnfrsf10b
anti-basement membrane glomerulonephritisMapk8
arteriosclerosisTnfsf10
asthmaChuk
astroblastomaPik3r1
atherosclerosisCasp3
atopic dermatitisCasp8 , Mapk8
AtrophyMapk3
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autism spectrum disorderMapk3
autistic disorderMapk1
Autoimmune DiseasesCasp8
autoimmune lymphoproliferative syndromeCasp8
autoimmune lymphoproliferative syndrome type 2BCasp8
autosomal recessive polycystic kidney diseasePik3ca
B-Cell Chronic Lymphocytic LeukemiaTnfrsf10b
bacterial infectious diseaseCasp3 , Casp8
bacterial pneumoniaChuk
Bannayan-Riley-Ruvalcaba syndromePik3ca
basal cell carcinomaPik3ca
Behcet's diseaseIkbkg
bladder urothelial carcinomaPik3ca
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
Brain ContusionCasp3 , Casp8
Brain DeathMap2k4
brain gliomaCasp3 , Fadd
Brain InjuriesCasp3 , Casp8 , Tnfsf10
brain ischemiaCasp3 , Mapk1 , Mapk3 , Mapk8
Brain NeoplasmsPik3ca , Pik3r1
breast adenocarcinomaPik3ca
breast cancerCasp8 , Pik3ca
Breast Cancer, FamilialPik3ca , Pik3r3
Breast NeoplasmsCasp3 , Casp7 , Casp8 , Dap3 , Ikbkb , Map2k4 , Map3k1 , Mapk1 , Pik3ca , Pik3r1 , Tnfrsf10b , Tnfsf10
Bronchopulmonary DysplasiaBid , Casp3 , Casp8
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsCasp3 , Tnfrsf10b
calcinosisCasp3
cancerPik3ca , Pik3r1
Carbon Tetrachloride PoisoningFadd
carcinomaPik3r1
Cardiac ArrhythmiasMap2k4
CardiomegalyMapk1 , Mapk8
cardiomyopathyMapk1 , Mapk3
Carotid Artery InjuriesCflar
cataractCasp3
Cell Transformation, NeoplasticMapk8
Cerebral HemorrhageCasp3 , Casp8
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
Chemical and Drug Induced Liver InjuryCasp8 , Fadd
chemical colitisCasp3 , Casp7
childhood pilocytic astrocytomaMapk1
Choroidal NeovascularizationIkbkb
Chronic HepatitisCasp3
Chronic Intermittent HypoxiaFadd
chronic obstructive pulmonary diseaseCasp3 , Casp8 , Map2k4 , Mapk8
cleft palateChuk
CLOVES syndromePik3ca
Cocaine-Related DisordersMapk1 , Mapk3
cocoon syndromeChuk
colitisChuk , Ikbkb
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3
colon cancerPik3ca
colon carcinomaPik3ca
Colonic NeoplasmsCasp3 , Casp7 , Ikbkb , Mapk8 , Pik3ca , Pik3r1 , Pik3r2 , Tnfrsf10b , Tnfsf10
colorectal adenocarcinomaMapk1 , Mapk3 , Mapk8
colorectal adenomaMapk8
colorectal cancerPik3ca
Colorectal NeoplasmsCasp8 , Mapk1 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Tnfsf10
Combined Oxidative Phosphorylation Deficiency 11Ripk1
complex cortical dysplasia with other brain malformationsPik3ca
Congenital Limb DeformitiesChuk
congestive heart failureCasp3 , Cflar
contact dermatitisCasp8
Contrast-Induced NephropathyCasp3 , Mapk8
Copper-Overload CirrhosisCasp3
coronary restenosisMapk1
coronin-1A deficiencyMapk3
Cowden diseasePik3ca
Cowden Syndrome 5Pik3ca
Cowden-Like SyndromePik3ca
Craniofacial AbnormalitiesFadd
cryptorchidismCasp3
Currarino TriadPik3ca
demyelinating diseaseMapk1
dermatitisIkbkb
Developmental DisabilitiesPik3r2
Diabetes Mellitus, Experimental Casp3 , Casp8 , Ikbkb , Mapk1 , Mapk3 , Pik3r1 , Smpd1 , Tnfsf10
diabetic angiopathyCasp3
Diabetic CardiomyopathiesCasp3 , Casp8 , Mapk1 , Mapk3
Diabetic EmbryopathyFadd
Diabetic NephropathiesCasp3 , Casp7 , Casp8 , Mapk1 , Tnfsf10
diabetic neuropathyCasp3
diabetic retinopathyCasp3
diffuse large B-cell lymphomaPik3ca , Pik3cb , Pik3cd
dilated cardiomyopathyCasp3 , Casp8
disease of cellular proliferationPik3ca , Pik3r1 , Tnfrsf10b
Disease ProgressionPik3ca
drug allergyTnfrsf10b
EdemaCasp3 , Casp8
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerPik3cb , Pik3r1
endometrial carcinomaMapk1 , Mapk3 , Pik3ca , Pik3r1
Endometrial NeoplasmsMapk3 , Pik3ca , Pik3cb , Pik3cd , Tnfsf10
Endometrioid CarcinomasMapk1 , Mapk3 , Pik3r2
endometritisCasp3 , Casp7
EndotoxemiaCasp3 , Casp7
epidermal nevusPik3ca
esophageal carcinomaPik3ca
Esophageal NeoplasmsCasp8 , Tnfrsf10b
esophagus adenocarcinomaPik3ca
Experimental ArthritisIkbkb , Ikbkg , Pik3cd
Experimental Autoimmune EncephalomyelitisCasp3 , Casp8
Experimental Autoimmune MyocarditisCasp3 , Casp8
Experimental ColitisMapk1 , Mapk3
Experimental Liver CirrhosisCasp7 , Mapk1 , Mapk3
Experimental Liver NeoplasmsMapk1 , Mapk3
Experimental MelanomaIkbkb
Experimental NeoplasmsTnfsf10
Experimental PancreatitisIkbkg
extrahepatic cholestasisMapk1 , Mapk3 , Mapk8
Facial AsymmetryPik3ca
Familial Prostate CancerCasp8
FatigueTnfrsf10b
fatty liver diseaseIkbkg , Mapk8
favismIkbkg
Female InfertilityMapk1 , Mapk3
Fetal DiseasesChuk
Fetal Growth RetardationCasp3
gallbladder carcinomaPik3ca
gastric adenocarcinomaPik3ca
gastric ulcerCasp3 , Mapk1 , Mapk3
Gastrointestinal NeoplasmsPik3ca
genetic diseaseIkbkg , Map3k1 , Mapk1 , Pik3ca , Pik3r1 , Pik3r2
glioblastoma multiformePik3ca , Pik3cb , Pik3cd , Pik3r1 , Tnfsf10
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
glucosephosphate dehydrogenase deficiencyIkbkg
Growth DisordersPik3ca
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
head and neck squamous cell carcinomaMapk1 , Pik3ca , Tnfrsf10b
heart diseaseCasp3 , Casp8
heart valve diseaseCasp3
HemimegalencephalyPik3ca
hepatocellular carcinomaBid , Casp3 , Casp8 , Pik3ca , Tnfsf10
Hereditary Neoplastic SyndromesPik3ca
Hodgkin's lymphomaCflar
Human InfluenzaTnfsf10
Huntington's diseaseCasp3 , Casp8
HyperalgesiaMapk1 , Mapk3 , Mapk8
HypercholesterolemiaCasp3
hyperglycemiaCasp8
HyperoxiaCflar , Fadd
HyperplasiaIkbkb , Pik3ca
hypertensionCasp3 , Casp8 , Fadd , Ikbkb , Mapk8 , Pik3r1
hypertrophic cardiomyopathyCasp3
HypertrophyMapk1 , Mapk3
hypoglycemiaPik3r1
hypohidrotic ectodermal dysplasiaIkbkg
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
hypomelanosis of ItoIkbkg
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypoxiaCasp3
Hypoxia-Ischemia, BrainCasp3 , Casp8 , Fadd
idiopathic pulmonary fibrosisCflar
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
impotenceCasp3
InflammationChuk
inflammatory bowel diseaseIkbkb
Insulin ResistanceCasp3 , Casp8 , Ikbkb , Mapk3 , Pik3r1
intermittent claudicationCasp3
intestinal diseaseCasp3
Intestinal NeoplasmsMapk8
Intestinal Reperfusion InjuryCasp3
invasive ductal carcinomaMap2k4
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
irritable bowel syndromeIkbkg
juvenile rheumatoid arthritisMapk1
kidney diseaseCasp3 , Casp8 , Mapk1 , Smpd1
Kidney NeoplasmsMapk1 , Mapk3 , Tnfrsf10b , Tnfsf10
Kidney Reperfusion InjuryCasp3 , Casp7 , Ikbkb
Kuhnt-Junius degenerationMapk8
learning disabilityIkbkg
leukemiaCflar , Fadd , Tnfsf10
lichen planusRipk1
liver benign neoplasmTnfsf10
liver cancerCasp8 , Pik3ca
liver cirrhosisCasp3 , Casp8
Liver Reperfusion InjuryCasp8 , Fadd , Ikbkg , Mapk8 , Tradd
lung adenocarcinomaPik3ca , Pik3r1
lung cancerCasp8 , Pik3ca
Lung NeoplasmsCasp7 , Casp8 , Ikbkg , Mapk1 , Mapk3 , Pik3ca
Lung Reperfusion InjuryCasp3
lung small cell carcinomaPik3ca , Pik3r1
lung squamous cell carcinomaPik3ca
Lymphatic MetastasisPik3ca , Pik3cb
Lymphoma, Extranodal NK-T-CellCflar
macular degenerationTnfrsf10b
malignant gliomaMapk3 , Pik3ca , Pik3r3 , Tnfsf10
Mammary Neoplasms, ExperimentalCasp3 , Casp7 , Casp8 , Mapk1 , Mapk3 , Pik3r1 , Tnfrsf10b , Tnfsf10
mantle cell lymphomaPik3cd , Tnfrsf10b
medulloblastomaPik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
melanomaCasp8 , Pik3ca , Pik3r1
mental depressionFadd
Metabolic SyndromeFadd
Microphthalmia, Syndromic 1Map3k1
middle cerebral artery infarctionCasp3 , Fadd , Ikbkb , Mapk1 , Mapk3
morphine dependenceFadd
Mouth NeoplasmsPik3ca
Multiple AbnormalitiesChuk , Mapk1 , Pik3r2
Multiple Hamartoma SyndromePik3ca
multiple myelomaPik3ca , Tnfrsf10b
Multiple Organ FailureMapk1
muscular atrophyChuk , Ikbkb
Mycoplasma InfectionsCasp3
myelodysplastic syndromeCflar
myocardial infarctionCasp3 , Mapk1
Myocardial Reperfusion InjuryBid , Casp3 , Casp7 , Casp8 , Cflar , Fadd , Mapk1 , Mapk3 , Mapk8
Nasopharyngeal NeoplasmsPik3ca
NauseaTnfrsf10b
Nematode InfectionsPik3r1
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessMapk1 , Mapk3 , Smpd1
Neoplasm MetastasisCasp3 , Chuk , Fadd , Mapk1 , Mapk3 , Pik3ca , Pik3r3 , Tnfsf10
Neovascularization, PathologicTnfsf10
nephritisCasp8
Nerve DegenerationCasp3 , Mapk1 , Mapk3
nervous system diseaseCasp3
neuroblastomaMap2k4 , Pik3ca , Tnfsf10
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3 , Smpd1
neutropeniaTnfrsf10b
Niemann-Pick diseaseSmpd1
Niemann-Pick disease type ASmpd1
Niemann-Pick disease type BSmpd1
Niemann-Pick Disease, Intermediate, Protracted NeurovisceralSmpd1
non-Hodgkin lymphomaPik3ca
non-small cell lung carcinomaCasp3 , Casp7 , Casp8 , Pik3ca
nonalcoholic fatty liver diseaseIkbkg , Mapk8
obesityFadd , Ikbkb , Mapk1 , Mapk3 , Pik3r1
Optic Nerve InjuriesTradd
osteoarthritisCasp3 , Tnfrsf10b , Tnfsf10
Osteoarthritis, ExperimentalCasp3 , Casp7 , Casp8 , Mapk3
ovarian cancerPik3ca
Ovarian NeoplasmsMap2k4 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Tnfsf10
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyMapk8
pancreatic adenocarcinomaPik3ca
pancreatic cancerBid , Casp8 , Cflar , Map2k4 , Tnfsf10
pancreatitisCasp3 , Ikbkb
papillary renal cell carcinomaPik3ca
papillomaMap2k4
Papillomavirus InfectionsCasp8
Parkinson's diseaseCasp3
Parkinsonian DisordersCasp3
penile neoplasmPik3ca
perinatal necrotizing enterocolitisIkbkg
peripheral nervous system diseaseTnfrsf10b
Plaque, AtheroscleroticCflar
plasmacytomaPik3ca
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaIkbkb
polycystic ovary syndromeTnfsf10
portal hypertensionPik3r1
pre-malignant neoplasmBid , Casp3 , Casp8 , Mapk8
precursor lymphoblastic lymphoma/leukemiaCasp8
primary immunodeficiency diseaseCasp8
prostate adenocarcinomaChuk , Ikbkb , Mapk1 , Pik3ca , Pik3cb
prostate cancerChuk , Ikbkb , Pik3ca , Pik3cb , Pik3r1 , Pik3r2
prostate carcinoma in situMap2k4
prostatic hypertrophyFadd
Prostatic NeoplasmsCasp3 , Chuk , Map2k4 , Map3k1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Tnfrsf10b , Tnfsf10
psoriasisIkbkb
PTEN hamartoma tumor syndromePik3ca
pulmonary fibrosisCflar
pulmonary hypertensionMapk1 , Mapk3
Radiation Injuries, ExperimentalCasp3 , Casp8 , Mapk1 , Mapk3
rectal neoplasmMapk8 , Pik3ca , Pik3cb
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
renal carcinomaPik3ca
renal cell carcinomaCasp3 , Mapk1 , Pik3ca , Pik3r1 , Tnfrsf10b , Tnfsf10
renal fibrosisMapk1
Reperfusion InjuryBid , Casp3 , Casp8 , Mapk8 , Pik3r1
Retina Reperfusion InjuryCasp7 , Map2k4
retinal detachmentCasp3 , Casp8
retinal diseaseCasp3
retinitis pigmentosaCasp7 , Ripk1
rheumatoid arthritisCasp7
salivary gland diseaseCasp3
sarcomaPik3ca
schizophreniaMapk3 , Pik3cb
sciatic neuropathyCasp3 , Casp7 , Casp8
scrapieCasp3
seborrheic keratosisPik3ca
sensorineural hearing lossFadd
SepsisCasp3 , Casp8 , Mapk1 , Mapk3
Septic PeritonitisPik3r1
Sezary's diseaseMapk1
ShockMapk1 , Mapk3
Shock, HemorrhagicCasp3 , Casp8 , Mapk1
SHORT SyndromePik3r1
Skin AbnormalitiesChuk
skin cancerChuk
skin melanomaPik3ca
Skin NeoplasmsCasp8 , Map2k4
Sleep DeprivationMap2k4
small cell carcinomaTnfsf10
spermatic cord torsionCasp3
Spinal Cord InjuriesCasp3 , Fadd
Spinocerebellar AtaxiasCasp7
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaMapk1 , Mapk3 , Pik3ca , Ripk1
status epilepticusCasp3 , Casp8
stomach cancerPik3ca
Stomach NeoplasmsBid , Casp8 , Mapk1 , Mapk3 , Mapk8 , Pik3ca
Stomatognathic DiseasesFadd
StrokeCasp3 , Mapk8 , Pik3ca
Subarachnoid HemorrhageCasp3
Testis Reperfusion InjuryCasp3 , Mapk1 , Mapk3
thrombocytopeniaTnfrsf10b
thrombosisPik3cb
thyroid cancerMapk1
Thyroid NeoplasmsPik3ca
toxic encephalopathyCasp3
transient cerebral ischemiaCasp3 , Casp7 , Casp8 , Ikbkb , Map2k4
transitional cell carcinomaCasp3 , Mapk1 , Pik3ca
Transplant RejectionIkbkb
trigeminal neuralgiaMapk1 , Mapk3 , Mapk8
type 1 diabetes mellitusCasp3 , Casp8 , Tnfsf10
type 2 diabetes mellitusCasp3 , Casp7 , Casp8 , Ikbkb , Mapk1 , Mapk3 , Mapk8 , Pik3cb , Pik3r1
ulcerative colitisCasp3
ureteral obstructionCasp3 , Casp7 , Mapk1 , Mapk3
urethral obstructionMapk1
urinary bladder cancerCasp3 , Map2k4 , Tnfrsf10b
Urinary IncontinenceMapk1
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsCasp3 , Casp8 , Mapk1 , Pik3ca , Tnfrsf10b
Uterine NeoplasmsPik3ca , Pik3r1
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Viral MyocarditisCasp3 , Casp8
visual epilepsyPik3ca
vitiligoCasp7 , Pik3r1
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
Wilson diseaseSmpd1
withdrawal disorderMapk1 , Mapk3
Pathway Annotations Associated with Genes in the Trail mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
adenosine signaling pathwayChuk , Ikbkb , Map3k1 , Mapk1 , Mapk8 , Pik3ca
aldosterone signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
Alzheimer's disease pathwayBid , Casp3 , Casp7 , Casp8 , Fadd , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBid , Casp3
apoptotic cell death pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Bone morphogenetic proteins signaling pathwayMapk1
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map3k1 , Mapk8 , Traf2
ceramide signaling pathwayBid , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tradd , Traf2
Chagas disease pathwayCasp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
colorectal cancer pathwayCasp3 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
cytokine mediated signaling pathwayTnfsf10
E-cadherin signaling pathwayPik3ca , Pik3r1
endometrial cancer pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Endoplasmic Reticulum-associated degradation pathwayMapk8 , Traf2
endothelin signaling pathwayMapk1 , Mapk3 , Mapk8
Entamoebiasis pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
ephrin - ephrin receptor bidirectional signaling axisMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
erythropoietin signaling pathwayMapk8 , Pik3r1
extrinsic apoptotic pathwayCasp3 , Casp7 , Casp8
FasL mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1
Fc epsilon receptor mediated signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc gamma receptor mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3r1
glioma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
glutamate signaling pathwayMapk1 , Mapk3
glutathione metabolic pathwayCasp7
glutathione synthase deficiency pathwayCasp7
glutathionuria disease pathwayCasp7
glypican signaling pathwayMapk8
gonadotropin-releasing hormone signaling pathwayMap2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1
hepatitis C pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd , Traf2
Huntington's disease pathwayCasp3 , Casp8
inflammatory response pathwayMapk8
influenza A pathwayIkbkb , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayMapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayPik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayMap2k4 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBid , Casp3 , Casp7
Jak-Stat signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Leishmaniasis pathwayMapk1 , Mapk3
long term depressionMapk1 , Mapk3
long term potentiationMapk1 , Mapk3
measles pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Tnfrsf10b , Tnfsf10
melanoma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
mitogen activated protein kinase signaling pathwayCasp3 , Chuk , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Traf2
mTOR signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
myocarditis pathwayBid , Casp3 , Casp8
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
neurotrophic factor signaling pathwayIkbkb , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
NOD-like receptor signaling pathwayCasp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8
non-small cell lung carcinoma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayMap3k1 , Traf2
p53 signaling pathwayBid , Casp3 , Casp8 , Mapk8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Parkinson's disease pathwayCasp3
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayMap2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
primary immunodeficiency pathwayIkbkg
prion disease pathwayMapk1 , Mapk3
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
renal cell carcinoma pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Mapk8 , Ripk1 , Tradd , Traf2
Rho/Rac/Cdc42 mediated signaling pathwayMap2k4 , Mapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung carcinoma pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Traf2
sphingolipid metabolic pathwaySmpd1
sphingosine 1-phosphate signaling pathwayMapk1 , Mapk3 , Mapk8
syndecan signaling pathwayCasp3 , Mapk1 , Mapk3 , Mapk8
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Mapk1 , Mapk3
thyroid cancer pathwayMapk1 , Mapk3
titanium dioxide nanoparticle response pathwayCasp3 , Casp8
Toll-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd
toxoplasmosis pathwayCasp3 , Casp8 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayBid , Casp3 , Casp7 , Casp8 , Cflar , Chuk , Dap3 , Fadd , Ikbkb , Ikbkg , Map2k4 , Map3k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Smpd1 , Tnfrsf10b , Tnfsf10 , Tradd , Traf2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3
tuberculosis pathwayBid , Casp3 , Casp8 , Fadd , Mapk1 , Mapk3 , Mapk8 , Tradd
tumor necrosis factor mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Ripk1 , Smpd1 , Tradd , Traf2
type 2 diabetes mellitus pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
type II interferon signaling pathwayMap3k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayMap3k1
urinary bladder cancer pathwayMapk1 , Mapk3
vascular endothelial growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Wnt signaling pathwayMapk8
Wnt signaling, non-canonical pathwayMapk8

References Associated with the Trail mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: