GLYCOLYSIS PATHWAY (PW:0000640)

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Description

Glucose is a major source of energy in the cell. In the first round of breakdown - a pathway known as glycolysis, one of the best characterized biochemical pathways - one molecule of glucose is converted to two molecules of pyruvate with a net yield of 2 ATP and the reduction of 2 NAD+ to 2 NADH. The 10 enzymatic reactions of glycolysis can be divided into two stages: an energy consumption stage I (reactions 1 to 5) and an energy recovery/generation stage II (reactions 6 to 10)

Pathway Diagram:

Ariadne Genomics Inc. phosphoenolpyruvate gluconeogenesis pathway pyruvate metabolic pathway aldolases Pfkfb members (kinase) Pfkfb members (phosphatase) phosphofructokinases enolases hexokinases ATP ---| phosphofructokinases F2,6P --+> phosphofructokinases AMP --+> phosphofructokinases Tpi1 glyceraldehyde-3-phosphate <--> dihydroxyacetone-phosphate Gapdh Pgk1 Pgam2 Pkm2 Gpi glucose Pfkfb members (phosphatase) ---| F2,6P phosphoenolpyruvate ---> pyruvate glyceraldehyde-3-phosphate <--> 1,3-biphosphoglycerate fructose-1,6-diphosphate <--> glyceraldehyde-3-phosphate 3-phosphoglycerate <--> 2-phosphoglycerate pyruvate ---> pyruvate metabolic pathway pyruvate fructose-6-phosphate ---> fructose-1,6-diphosphate Pfkfb members (kinase) --+> F2,6P ATP ---- phosphofructokinases pyruvate ---> gluconeogenesis pathway glucose-6-phosphate <--> fructose-6-phosphate fructose-1,6-diphosphate <--> dihydroxyacetone-phosphate AMP F2,6P 3-phosphoglycerate <--> 1,3-biphosphoglycerate 1,3-biphosphoglycerate 3-phosphoglycerate 2-phosphoglycerate glucose-6-phosphate fructose-6-phosphate ATP fructose-1,6-diphosphate dihydroxyacetone-phosphate glyceraldehyde-3-phosphate Pklr 2-phosphoglycerate <--> phosphoenolpyruvate glucose ---> glucose-6-phosphate
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Genes in Pathway:

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glycolysis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acss1 acyl-CoA synthetase short-chain family member 1 JBrowse link 3 146,420,346 146,470,293 RGD:6907045
G Acss2 acyl-CoA synthetase short-chain family member 2 JBrowse link 3 151,032,925 151,075,856 RGD:6907045
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:6907045
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 2 243,728,500 243,740,907 RGD:6907045
G Adh6 alcohol dehydrogenase 6 (class V) JBrowse link 2 243,656,568 243,687,857 RGD:6907045
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6907045
G Adpgk ADP-dependent glucokinase JBrowse link 8 64,088,871 64,116,832 RGD:6907045
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:6907045
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6907045
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 JBrowse link 1 127,302,920 127,337,828 RGD:6907045
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 JBrowse link 1 240,584,233 240,601,843 RGD:6907045
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 JBrowse link 5 61,382,351 61,387,359 RGD:6907045
G Aldh2 aldehyde dehydrogenase 2 family (mitochondrial) JBrowse link 12 40,466,418 40,498,813 RGD:6907045
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:6907045
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 JBrowse link 10 47,525,486 47,546,535 RGD:6907045
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 JBrowse link 1 219,145,457 219,181,536 RGD:6907045
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 JBrowse link 18 51,619,007 51,651,267 RGD:6907045
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 JBrowse link 13 85,580,828 85,597,497 RGD:6907045
G Aldoa aldolase, fructose-bisphosphate A JBrowse link 1 198,228,387 198,233,988 RGD:2302796
RGD:10402751
RGD:6907045
G Aldob aldolase, fructose-bisphosphate B JBrowse link 5 64,805,772 64,818,813 RGD:2302796
RGD:6907045
RGD:2302804
G Aldoc aldolase, fructose-bisphosphate C JBrowse link 10 65,586,504 65,590,093 RGD:6907045
G Bpgm bisphosphoglycerate mutase JBrowse link 4 61,912,210 61,940,697 RGD:6907045
RGD:10402751
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:6907045
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:6907045
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:2302799
RGD:10402751
RGD:6907045
G Eno2 enolase 2 JBrowse link 4 157,285,192 157,294,090 RGD:2302804
RGD:6907045
G Eno3 enolase 3 JBrowse link 10 57,278,271 57,283,661 RGD:6907045
G Fbp1 fructose-bisphosphatase 1 JBrowse link 17 396,175 417,480 RGD:6907045
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6907045
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6907045
RGD:10402751
G Galm galactose mutarotase JBrowse link 6 2,808,988 2,860,742 RGD:6907045
RGD:10402751
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:6907045
RGD:10402751
G Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic JBrowse link 1 89,180,063 89,195,347 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:2302784
RGD:6907045
RGD:2302851
RGD:2302790
G Gpi glucose-6-phosphate isomerase JBrowse link 1 90,063,411 90,091,287 RGD:6907045
RGD:10402751
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:2302784
RGD:6907045
RGD:2302851
RGD:2302804
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:2302784
RGD:10402751
RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:2302784
RGD:6907045
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6907045
G Ldhal6b lactate dehydrogenase A-like 6B JBrowse link 1 46,307,853 46,309,276 RGD:6907045
G Ldhb lactate dehydrogenase B JBrowse link 4 176,701,980 176,719,999 RGD:6907045
G Ldhc lactate dehydrogenase C JBrowse link 1 102,914,875 102,931,843 RGD:6907045
G Pank1 pantothenate kinase 1 JBrowse link 1 253,115,400 253,189,643 RGD:10402751
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6907045
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) JBrowse link 15 34,216,735 34,224,357 RGD:6907045
G Pdha1 pyruvate dehydrogenase E1 alpha 1 subunit JBrowse link X 37,329,779 37,343,410 RGD:6907045
G Pdha2 pyruvate dehydrogenase E1 alpha 2 subunit JBrowse link 2 246,736,449 246,737,997 RGD:6907045
G Pdhb pyruvate dehydrogenase E1 beta subunit JBrowse link 15 18,540,826 18,546,855 RGD:6907045
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 JBrowse link X 23,092,143 23,145,923 RGD:2302793
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 JBrowse link 13 47,413,453 47,440,682 RGD:2302793
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 JBrowse link 17 70,632,778 70,713,736 RGD:2302793
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 JBrowse link 8 117,733,347 117,776,525 RGD:2302793
G Pfkl phosphofructokinase, liver type JBrowse link 20 11,393,860 11,415,889 RGD:2302736
RGD:6907045
RGD:2302851
RGD:2302790
G Pfkm phosphofructokinase, muscle JBrowse link 7 139,702,066 139,722,132 RGD:2302736
RGD:10402751
RGD:6907045
G Pfkp phosphofructokinase, platelet JBrowse link 17 68,510,765 68,574,387 RGD:2302736
RGD:6907045
RGD:2302804
G Pgam1 phosphoglycerate mutase 1 JBrowse link 1 261,158,204 261,165,814 RGD:2302794
RGD:10402751
RGD:6907045
G Pgam2 phosphoglycerate mutase 2 JBrowse link 14 86,045,005 86,047,116 RGD:2302794
RGD:10402751
RGD:6907045
G Pgk1 phosphoglycerate kinase 1 JBrowse link X 77,263,399 77,279,373 RGD:2302859
RGD:6907045
RGD:2302860
G Pgk2 phosphoglycerate kinase 2 JBrowse link 9 24,095,774 24,097,340 RGD:6907045
G Pgm1 phosphoglucomutase 1 JBrowse link 5 118,743,632 118,803,055 RGD:6907045
G Pklr pyruvate kinase L/R JBrowse link 2 188,449,158 188,458,034 RGD:2302790
RGD:10402751
RGD:6907045
RGD:2302851
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:2302790
RGD:2302804
G RGD1560402 similar to Phosphoglycerate kinase 1 JBrowse link 2 42,726,747 42,728,100 RGD:6907045
G RGD1560797 similar to glyceraldehyde-3-phosphate dehydrogenase JBrowse link 15 85,087,422 85,112,505 RGD:6907045
G RGD1560826 similar to glyceraldehyde-3-phosphate dehydrogenase JBrowse link 2 226,825,623 226,826,642 RGD:6907045
G RGD1562690 similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M) JBrowse link 8 33,075,109 33,076,725 RGD:6907045
G RGD1562758 similar to glyceraldehyde-3-phosphate dehydrogenase JBrowse link 18 63,824,239 63,826,908 RGD:6907045
G RGD1563601 similar to Tpi1 protein JBrowse link 17 27,764,761 27,765,800 RGD:6907045
G RGD1564958 similar to glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) JBrowse link 16 16,948,541 16,950,239 RGD:6907045
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:10402751
G Tpi1 triosephosphate isomerase 1 JBrowse link 4 157,328,375 157,331,905 RGD:6907045
RGD:10402751

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassPfkfb members (phosphatase)members of the bifunctional elzyme that catalyzes the synthesis and degradation of F2,6P
Functional ClassPfkfb members (kinase)members of the bifunctional elzyme that catalyzes the synthesis and degradation of F2,6P
Functional Classaldolasesthe aldolase isozymes
Functional Classenolasesthe enolase isozymes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the glycolysis pathway
Disease TermsGene Symbols
16p11.2 Deletion SyndromeAldoa
Acid-Base ImbalanceFbp1
Acute Coronary SyndromeEno1 , Gapdh , Ldhb
acute myeloid leukemiaEno2 , Gpi
adenocarcinomaEno1 , Pgam1
Adenosine Triphosphate, Elevated, of ErythrocytesPklr
alcohol dependenceAldh2
Alcohol Sensitivity, AcuteAldh2
alcohol use disorderAdh5 , Aldh2
alcohol-induced mental disorderAldh2
Alcoholic Fatty LiverAldh2
Alzheimer's diseaseAldh2 , Eno1 , Gapdh , Gapdhs , Pck1 , Tpi1
anemiaHk1
Animal Disease ModelsEno1 , Gapdh , Gpi , Hk1 , Hk2 , Ldha , Tpi1
Animal Mammary NeoplasmsEno1 , Pgam1 , Pkm
aortic valve stenosisEno3
Arsenic PoisoningPfkfb3
arteriosclerosisAldh3a1
asthmaAdh5 , Aldh2
AtrophyEno2
autism spectrum disorderAldoa
autistic disorderAldh1a3 , Aldh3a1 , Aldh3a2 , Aldoa , Pdha1 , Pfkfb1 , Pfkfb2 , Pfkl , Pgk1
autoimmune disease of the nervous systemAldoc
autoimmune hepatitisAldob
autoimmune polyendocrine syndrome type 1Pfkl
benign neonatal seizuresAldh7a1
Bisphosphoglycerate Mutase DeficiencyBpgm
bone diseaseAldh7a1
borna diseaseAldoc
brain diseaseEno2
brain gliomaGapdh
brain infarctionAldh2
breast carcinomaEno2
Breast NeoplasmsAldoa , Eno1 , Gpi , Ldhal6b , Ldhb , Slc2a2
BurnsPklr
carbohydrate metabolic disorderTpi1
Carcinoid TumorEno2
carcinomaEno1 , Pgam1 , Pkm
cardiomyopathyLdha
cataractAldh3a1
Cell Transformation, NeoplasticAldh1a1 , Eno2
Charcot-Marie-Tooth disease dominant intermediate CAkr1a1
Charcot-Marie-Tooth disease type 4GHk1
Chemical and Drug Induced Liver InjuryAldh2 , Aldh9a1 , Aldob , Dlat , Eno1 , Pgm1
cholestasisAdh5 , Aldh1b1
Chronic Intermittent HypoxiaHk1 , Hk2
colobomaAldh7a1
Colonic NeoplasmsAldh1b1 , Fbp1
colorectal cancerHk1
Colorectal NeoplasmsAldh2 , Gapdh , Pgm1
congenital disorder of glycosylationPgm1
congenital hemolytic anemiaGpi
Congenital HyperinsulinismGck
Congenital Infantile Lactic Acidosis due to LAD DeficiencyDld
congenital nonspherocytic hemolytic anemiaGpi , Hk1 , Pklr , Tpi1
congestive heart failurePck1
Corneal InjuriesAldh3a1
coronary artery diseaseGck
coronin-1A deficiencyAldoa
Creutzfeldt-Jakob diseaseAldh1a1
cystadenomaAldoa
Diabetes ComplicationsAldh2
diabetes mellitusAldob , Gck , Slc2a2
Diabetes Mellitus, Experimental Aldob , Eno2 , G6pc , Gapdh , Gck , Hk1 , Pck1 , Pfkm , Pklr , Slc2a2 , Tpi1
diabetic neuropathyAldh2
diabetic retinopathyGapdh
Dimauro DiseasePgam2
Disease ProgressionAldh7a1 , Pdha1
ductal carcinoma in situLdhb
DwarfismG6pc
endometrial cancerPgm1
Endometrioid CarcinomasEno2
EndotoxemiaAldoa , Pck1 , Pck2
epilepsyAldh7a1 , Gapdh
esophageal cancerAldh2
Esophageal NeoplasmsAdh7 , Aldh2 , Eno1 , Gapdh
Experimental ArthritisGpi
Experimental Liver CirrhosisAdh4 , Aldh1a1 , Aldh1b1 , Aldh2 , G6pc , Gck , Ldhb , Pck1 , Pck2 , Pfkp , Pklr
Experimental Liver NeoplasmsEno2
Experimental MelanomaAcss1 , Acss2
Experimental NeoplasmsEno2 , Ldha
extrinsic cardiomyopathyPfkfb3
familial hyperinsulinemic hypoglycemia 3Gck
Fanconi syndromeLdha , Slc2a2
fatty liver diseaseGck , Slc2a2
Fetal Growth RetardationG6pc , Pck1 , Slc2a2
FlushingAldh2
fructose-1,6-bisphosphatase deficiencyFbp1
gastrinomaSlc2a2
Gaucher's diseasePklr
Generalized EpilepsyPgk1
genetic diseaseAldh7a1 , Dlat , Dld , Gck , Pdha1 , Pgk1
Genetic Predisposition to DiseaseAldh2
gestational diabetesG6pc , Gck
GlucagonomaSlc2a2
glycogen storage diseaseSlc2a2
glycogen storage disease IG6pc
Glycogen Storage Disease IAG6pc
Glycogen Storage Disease IBG6pc
glycogen storage disease VIIPfkm
Glycogen Storage Disease XIIAldoa
Glycogen Storage Disease XIIIEno3
Glycogen Storage Disease XIVPgm1
heart diseaseAldh2
Heart InjuriesAldh2
hemolytic anemiaGpi , Pgk1 , Tpi1
hepatocellular carcinomaAdh4 , Aldoc , Eno1 , Fbp1 , Gapdh , Pck1 , Pgk1 , Pkm , Slc2a2
HepatomegalyAldh1b1
hereditary fructose intolerance syndromeAldoa , Aldob
Hereditary Neoplastic SyndromesAldh7a1
Huntington's diseaseGapdh
hyperglycemiaGck , Ldha , Pck1 , Pklr
hyperinsulinemic hypoglycemiaGck
hyperinsulinismGck , Pfkfb1 , Pklr
hypertensionAldh2 , Eno1 , Eno2 , Gck
hypoglycemiaG6pc , Gck
hypoparathyroidism-deafness-renal disease syndromePfkfb3
HypothermiaAcss1
HypoxiaAldob , Gapdh , Pck2
InflammationAcss2
inherited metabolic disorderLdhb , Tpi1
Insulin ResistanceGck , Pklr
insulinomaSlc2a2
intellectual disabilityGpi
isolated microphthalmia 8Aldh1a3
Kidney NeoplasmsEno2
Kidney Reperfusion InjuryAldh2
Lactate Dehydrogenase B DeficiencyLdhb
Lactate Dehydrogenase Deficiency Type ALdha
lactic acidosisPdha1
Laryngeal NeoplasmsAdh7
Leigh diseaseDld
Leigh Syndrome, X-LinkedPdha1
LeukoencephalopathiesAldh7a1
liver benign neoplasmAldob
liver diseaseAldh2 , Eno3 , Hk3
Liver InjuryGck
long QT syndromeAcss2 , Hk3
lung diseaseLdhc
malariaPklr
male infertilityAldh2 , Eno1 , Ldhc
Mammary Neoplasms, ExperimentalEno1 , Pgam1 , Pkm
maple syrup urine diseaseDld
Matthew-Wood syndromeAldh1a3
maturity-onset diabetes of the youngGck
maturity-onset diabetes of the young type 2Gck
melanomaPck1
MelanosisAldh2
Metabolic SyndromeAldoa
Microphthalmia, Syndromic 1Pfkp
middle cerebral artery infarctionGapdh
migraine without auraEno2
morbid obesityAcss2
Mouth NeoplasmsAdh7 , Eno1 , Gapdh , Pgam1 , Tpi1
Multiple AbnormalitiesDlat , Pdha1
multiple myelomaHk1
Multiple TraumaEno2
myocardial infarctionAldh2 , Ldha
Myocardial IschemiaAldh2 , Aldoa , Dlat , Hk1 , Hk2 , Pdha1 , Pfkfb3 , Pfkm , Pgm1
Myocardial Reperfusion InjuryAldh2 , Gapdh
Myoclonic EpilepsiesDld
Myoclonic Epilepsy, Familial InfantileDld
myoglobinuriaLdha , Pgam2
NecrosisGapdh
neonatal diabetes mellitusGck
Neoplasm InvasivenessAldoa , Eno1 , Ldhb , Pkm
Neoplasm MetastasisAldoa , Gpi
Neoplasms, Nerve TissueEno2
neural tube defectSlc2a2
neuroendocrine carcinomaEno2
neuromuscular diseaseGpi , Tpi1
Neuromuscular ManifestationsTpi1
non-small cell lung carcinomaEno1 , Eno2 , Pgam1
nonalcoholic fatty liver diseaseAdh4 , Aldh1a1 , Aldh1b1 , Aldh2
Nonspherocytic Hemolytic Anemia due to Glucose Phosphate Isomerase DeficiencyGpi
Nonspherocytic Hemolytic Anemia, due to Hexokinase DeficiencyHk1
obesityGapdh , Gck , Hk1 , Hk2 , Pck1 , Pfkfb3 , Pklr
occupational dermatitisAldh2
ocular hypertensionTpi1
oral squamous cell carcinomaGapdh
orofacial cleftAcss2
osteoarthritisEno1 , Gapdh , Pdha1
osteoporosisEno1 , Gapdh , Pkm , Tpi1
pancreatic cancerAldh1a1 , Aldh2
pancreatic ductal carcinomaSlc2a2
Parkinson's diseaseAdh7 , Fbp1
Parkinsonian DisordersAldh1a1 , Eno2
perinatal necrotizing enterocolitisAkr1a1 , Aldh2 , Eno1
peritonitisAldob
permanent neonatal diabetes mellitusGck
Pharyngeal NeoplasmsAdh7
Phosphoenolpyruvate Carboxykinase DeficiencyPck1
Phosphoenolpyruvate Carboxykinase Deficiency, MitochondrialPck2
Phosphoglycerate Kinase 1 DeficiencyPgk1
pleomorphic xanthoastrocytomaBpgm , Dld , Gck , Pgam2
Potocki-Lupski syndromeAldh3a1 , Aldh3a2
pre-malignant neoplasmAldh2
precursor lymphoblastic lymphoma/leukemiaGpi , Hk1
Pregnancy in DiabeticsGapdh
prostate cancerAldh9a1 , Dlat , Eno2 , Gapdhs
Prostatic NeoplasmsLdhb , Pdha1 , Pgam2
Pseudovaginal Perineoscrotal HypospadiasAldoa
pulmonary hypertensionAdh5 , Hk1
Pyridoxine-Dependent EpilepsyAldh7a1
pyruvate decarboxylase deficiencyDlat , Dld , Pdha1 , Pdhb
Pyruvate Dehydrogenase E1 Alpha DeficiencyPdha1
Pyruvate Dehydrogenase E1-Beta DeficiencyPdhb
Pyruvate Dehydrogenase E2 DeficiencyDlat
pyruvate kinase deficiency of red cellsPklr
Pyruvate Metabolism, Inborn ErrorsPdha1
RASopathiesGalm
renal cell carcinomaAldh1a1 , Ldhb , Pdhb , Pgk1
Reperfusion InjuryAldoa , Eno2 , Pklr
retinitis pigmentosaHk1
Retinitis Pigmentosa 79Hk1
RhabdomyolysisPfkm , Pgam2
rheumatic heart diseaseGapdh
rheumatoid arthritisEno1
schizophreniaAdpgk , Aldh1a3 , Aldoa , Aldob , Pfkfb3 , Pfkp
Shock, HemorrhagicAldh1a7
sickle cell anemiaHk1
Sjogren-Larsson syndromeAldh3a2
skin diseasePfkfb3
Sleep DeprivationDlat
spermatogenic failure 1Pdha2
Spinal Cord InjuriesEno2 , Gapdh
Spinal Cord Reperfusion InjuryGapdh
Spondylocostal Dysostosis 5Aldoa
squamous cell carcinomaEno1 , Gapdh , Pgam1 , Tpi1
Stomach NeoplasmsAldh1a3 , Aldh7a1 , Aldob , Eno1 , Fbp1 , Pdha1 , Pgam1
StrokeAldoc
teratomaPgm1
toxic shock syndromeEno2
transient neonatal diabetes mellitusGck
triosephosphate isomerase deficiencyTpi1
type 1 diabetes mellitusAldh2
type 2 diabetes mellitusAldh2 , Aldob , G6pc , Gapdh , Gck , Hk1 , Hk2 , Pck1 , Pklr , Slc2a2
urinary bladder cancerEno2 , Hk1
Urologic NeoplasmsEno2
vascular diseaseAldh2
Ventricular DysfunctionAldh2
visual epilepsyAldh7a1 , Eno2 , Pdha1
Pathway Annotations Associated with Genes in the glycolysis pathway
Pathway TermsGene Symbols
2-aminoadipic 2-oxoadipic aciduria pathwayAldh7a1 , Dld
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathwayAldh2 , Dld
3-hydroxyisobutyric aciduria pathwayAldh2 , Dld
3-methylcrotonyl CoA carboxylase 1 deficiency pathwayAldh2 , Dld
3-methylglutaconic aciduria type 1 pathwayAldh2 , Dld
3-methylglutaconic aciduria type 3 pathwayAldh2 , Dld
alkaptonuria pathwayAldh3a1
altered galactose metabolic pathwayG6pc , Hk2
Alzheimer's disease pathwayGapdh , RGD1560797 , RGD1560826 , RGD1562758 , RGD1564958
amino sugar metabolic pathwayGck , Gpi , Hk1 , Hk2 , Hk3 , Pgm1
arginine and proline metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
ascorbate and aldarate metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
beta-alanine metabolic pathwayAldh1a1 , Aldh1a3 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh3b1 , Aldh7a1 , Aldh9a1
butanoate metabolic pathwayPdha1 , Pdha2 , Pdhb
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2 , Hk3
carnitine biosynthetic pathwayAldh9a1
carnosinemia pathwayAldh2
choline metabolic pathwayAldh7a1
citric acid cycle pathwayDlat , Dld , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb
congenital sucrase-isomaltase deficiency pathwayGck , Gpi , Hk2 , Pgm1
cyclophosphamide pharmacodynamics pathwayAldh1a1 , Aldh3a1
cyclophosphamide pharmacokinetics pathwayAldh1a1 , Aldh3a1
cysteine and methionine metabolic pathwayLdha , Ldhal6b , Ldhb , Ldhc , RGD1562690
D-glycericacidemia pathwayAldh3a1
dihydropyrimidine dehydrogenase deficiency pathwayAldh2 , Dld
dimethylglycine dehydrogenase deficiency pathwayAldh2 , Dld
disulfiram pharmacodynamics pathwayAcss1 , Acss2 , Aldh1b1 , Aldh2 , Aldh3a1
dopamine beta-hydroxylase deficiency pathwayAldh3a1
doxorubicin pharmacokinetics pathwayAkr1a1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPck1 , Pck2
electron transport chain pathwayGapdh
facilitative sugar transporter mediated glucose transport pathwaySlc2a2
familial lipoprotein lipase deficiency pathwayAldh3a1
Fanconi syndrome pathwayAldoa , Bpgm , Eno1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pfkm , Pgam1 , Pgam2 , Pklr , Slc2a2 , Tpi1
fatty acid beta degradation pathwayAcss1 , Acss2
fatty acid metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
felbamate pharmacokinetics pathwayAldh3a1
folate cycle metabolic pathwayDld
forkhead class A signaling pathwayAldob , G6pc , Gck , Pck1 , Pklr , Slc2a2
french type sialuria pathwayHk1
fructose and mannose metabolic pathwayAldoa , Aldob , Aldoc , Fbp1 , Fbp2 , Hk1 , Hk2 , Hk3 , Pfkfb1 , Pfkfb2 , Pfkfb3 , Pfkfb4 , Pfkl , Pfkm , Pfkp , RGD1563601 , Tpi1
fructose-1,6-bisphosphatase deficiency pathwayAldoa , Bpgm , Eno1 , Fbp1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pck1 , Pgam1 , Pgam2 , Pgm1 , Slc2a2 , Tpi1
fructosuria pathwayAldoa , Aldob , Fbp1 , Hk1 , Pfkfb1 , Pfkl , Tpi1
fumaric aciduria pathwayDlat , Dld , Pdha1 , Pdhb
GABA aminotransferase deficiency pathwayAldh2
galactokinase deficiency pathwayGck , Pgm1
galactose metabolic pathwayG6pc , Gck , Hk1 , Hk2 , Hk3 , Pfkl , Pfkm , Pfkp , Pgm1
galactosemia pathwayG6pc , Gck , Hk1 , Pgm1
GALE deficiency pathwayGck , Pgm1
gliclazide pharmacodynamics pathwaySlc2a2
gluconeogenesis pathwayAcss1 , Acss2 , Adh4 , Adh5 , Adh6 , Adh7 , Adpgk , Akr1a1 , Aldh1a1 , Aldh1a3 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh3b1 , Aldh7a1 , Aldh9a1 , Aldoa , Aldob , Aldoc , Bpgm , Dlat , Dld , Eno1 , Eno2 , Eno3 , Fbp1 , Fbp2 , G6pc , Galm , Gapdh , Gapdhs , Gck , Gpi , Hk1 , Hk2 , Hk3 , Ldha , Ldhal6b , Ldhb , Ldhc , Pank1 , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pfkfb1 , Pfkl , Pfkm , Pfkp , Pgam1 , Pgam2 , Pgk1 , Pgk2 , Pgm1 , Pklr , RGD1560402 , RGD1560797 , RGD1560826 , RGD1562690 , RGD1562758 , RGD1563601 , RGD1564958 , Slc2a2 , Tpi1
Glut1 deficiency syndrome pathwayG6pc
glutaric aciduria type I pathwayAldh7a1 , Dld
glyburide pharmacodynamics pathwaySlc2a2
glycerol kinase deficiency pathwayAldh3a1
glycerolipid metabolic pathwayAkr1a1 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh7a1 , Aldh9a1
glycine, serine and threonine metabolic pathwayAldh7a1 , Dld
glycogen biosynthetic pathwayGck , Pgm1
glycogen degradation pathwayG6pc , Pgm1
glycogen metabolic pathwayG6pc , Gck
glycogen storage disease type Ia pathwayAldoa , Bpgm , Eno1 , Fbp1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pck1 , Pgam1 , Pgam2 , Pgm1 , Slc2a2 , Tpi1
glycogen storage disease type Ib pathwayAldoa , Bpgm , Eno1 , Fbp1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pck1 , Pgam1 , Pgam2 , Pgm1 , Slc2a2 , Tpi1
glycogen storage disease type III pathwayGck , Gpi , Hk2 , Pgm1
glycogen storage disease type IV pathwayGck , Gpi , Hk2 , Pgm1
glycogen storage disease type VI pathwayGck , Gpi , Hk2 , Pgm1
glycogen storage disease type VII pathwayAldoa , Bpgm , Eno1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pfkm , Pgam1 , Pgam2 , Pklr , Slc2a2 , Tpi1
glycolysis pathwayAcss1 , Acss2 , Adh4 , Adh5 , Adh6 , Adh7 , Adpgk , Akr1a1 , Aldh1a1 , Aldh1a3 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh3b1 , Aldh7a1 , Aldh9a1 , Aldoa , Aldob , Aldoc , Bpgm , Dlat , Dld , Eno1 , Eno2 , Eno3 , Fbp1 , Fbp2 , G6pc , Galm , Gapdh , Gapdhs , Gck , Gpi , Hk1 , Hk2 , Hk3 , Ldha , Ldhal6b , Ldhb , Ldhc , Pank1 , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pfkfb1 , Pfkfb2 , Pfkfb3 , Pfkfb4 , Pfkl , Pfkm , Pfkp , Pgam1 , Pgam2 , Pgk1 , Pgk2 , Pgm1 , Pklr , Pkm , RGD1560402 , RGD1560797 , RGD1560826 , RGD1562690 , RGD1562758 , RGD1563601 , RGD1564958 , Slc2a2 , Tpi1
glycolysis/gluconeogenesis pathwayAcss1 , Acss2 , Adh4 , Adh5 , Adh6 , Adh7 , Adpgk , Akr1a1 , Aldh1a1 , Aldh1a3 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh3b1 , Aldh7a1 , Aldh9a1 , Aldoa , Aldob , Aldoc , Bpgm , Dlat , Dld , Eno1 , Eno2 , Eno3 , Fbp1 , Fbp2 , G6pc , Galm , Gapdh , Gapdhs , Gck , Gpi , Hk1 , Hk2 , Hk3 , Ldha , Ldhal6b , Ldhb , Ldhc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pfkl , Pfkm , Pfkp , Pgam1 , Pgam2 , Pgk1 , Pgk2 , Pgm1 , Pklr , RGD1560402 , RGD1560797 , RGD1560826 , RGD1562690 , RGD1562758 , RGD1563601 , RGD1564958 , Tpi1
hawkinsinuria pathwayAldh3a1
hereditary fructose intolerance syndrome pathwayAldoa , Aldob , Fbp1 , Hk1 , Pfkfb1 , Pfkl , Tpi1
hexosamine biosynthetic pathwayGpi
histidine metabolic pathwayAldh1a1 , Aldh1a3 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a1 , Aldh3a2 , Aldh3b1 , Aldh7a1 , Aldh9a1
histidinemia pathwayAldh2 , Aldh3a1
hyperlysinemia pathwayAldh7a1 , Dld
hypoxia inducible factor pathwayAldoa , Eno1 , Gck , Hk1 , Hk2 , Ldha , Pfkfb3 , Pfkl , Pgk1 , Pgm1 , Pkm
ifosfamide pharmacodynamics pathwayAldh1a1 , Aldh3a1
ifosfamide pharmacokinetics pathwayAldh1a1 , Aldh3a1
inositol phosphate metabolic pathwayRGD1563601 , Tpi1
insulin secretion pathwayGck , Slc2a2
insulin signaling pathwayFbp1 , Fbp2 , G6pc , Gck , Hk1 , Hk2 , Hk3 , Pck1 , Pck2 , Pklr
isobutyryl-CoA dehydrogenase deficiency pathwayAldh2 , Dld
isovaleric acidemia pathwayAldh2 , Dld
lactose biosynthetic pathwayG6pc
lactose degradation pathwaySlc2a2
lamivudine pharmacokinetics pathwayPgk1
Leigh disease pathwayAcss2 , Aldh2 , Dlat , Dld , Pck1 , Pdha1 , Pdhb , Pklr
lysine biosynthetic pathwayAldh7a1
lysine degradation pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld
malonic aciduria pathwayAcss1 , Dld , Ldhal6b
maple syrup urine disease pathwayAldh2 , Dld
maturity-onset diabetes of the young pathwayGck , Pklr , Slc2a2
methylmalonate semialdehyde dehydrogenase deficiency pathwayAldh2 , Dld
methylmalonic acidemia pathwayAldh2 , Dld
methylmalonic aciduria, cobalamin-related pathwayAcss1 , Dld , Ldhal6b
mitochondrial complex II deficiency pathwayDlat , Dld , Pdha1 , Pdhb
neviparine pharmacokinetics pathwayAldh1a1
nicotinamide adenine dinucleotide metabolic pathwayGapdh
nonketotic hyperglycinemia pathwayAldh2 , Dld
Notch signaling pathwayEno1
nucleotide sugar metabolic pathwayGck , Gpi , Hk1 , Hk2 , Hk3 , Pgm1
pantothenic acid metabolic pathwayPank1
pentose and glucuronate interconversion pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2
pentose phosphate pathwayAldoa , Aldob , Aldoc , Fbp1 , Fbp2 , Gpi , Pfkl , Pfkm , Pfkp , Pgm1
phase I biotransformation pathway via cytochrome P450Adh4 , Adh5 , Adh6 , Adh7 , Aldh1a3 , Aldh3a1 , Aldh3b1
phenylalanine metabolic pathwayAldh1a3 , Aldh3a1 , Aldh3b1
phosphoenolpyruvate carboxykinase deficiency pathwayAldoa , Bpgm , Eno1 , Fbp1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pck1 , Pgam1 , Pgam2 , Pgm1 , Slc2a2 , Tpi1
phytanic acid degradation pathwayAldh3a2
potassium channel inhibitors pharmacodynamics pathwaySlc2a2
primary hyperoxaluria type 2 pathwayAcss2 , Aldh2 , Dlat , Dld , Pck1 , Pdha1 , Pdhb , Pklr
propanoate metabolic pathwayAcss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld , Ldha , Ldhal6b , Ldhb , Ldhc , RGD1562690
propionic acidemia pathwayAldh2 , Dld
prostaglandin biosynthetic pathwayAkr1a1
purine metabolic pathwayPgm1 , Pklr
pyruvate decarboxylase deficiency pathwayAcss2 , Aldh2 , Dlat , Dld , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate dehydrogenase E1 deficiency pathwayAcss2 , Aldh2 , Dlat , Dld , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate dehydrogenase E2 deficiency pathwayDlat , Dld , Pdha1 , Pdhb
pyruvate dehydrogenase E3 deficiency pathwayDlat , Dld , Pdha1 , Pdhb
pyruvate kinase deficiency of red cells pathwayAcss2 , Aldh2 , Dlat , Dld , Pck1 , Pdha1 , Pdhb , Pklr
pyruvate metabolic pathwayAcss1 , Acss2 , Aldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dlat , Dld , Ldha , Ldhal6b , Ldhb , Ldhc , Pck1 , Pck2 , Pdha1 , Pdha2 , Pdhb , Pklr , Pkm , RGD1562690
Refsum disease pathwayAldh3a2
remethylation pathway of homocysteine metabolism - cobalamin independent, betaine dependentAldh7a1
retinoic acid metabolic pathwayAldh1a1 , Aldh1a3
retinol metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a1
ribose 5-phosphate isomerase deficiency pathwayAldoa , Fbp1 , Gpi , Pfkl , Pgm1
RNA degradation pathwayEno1 , Eno2 , Eno3
saccharopinuria pathwayAldh7a1 , Dld
sarcosinemia pathwayAldh2 , Dld
sialic acid storage disease pathwayHk1
starch and sucrose metabolic pathwayG6pc , Gck , Gpi , Hk1 , Hk2 , Hk3 , Pgm1
Tay-Sachs disease pathwayHk1
transaldolase deficiency pathwayAldoa , Fbp1 , Gpi , Pfkl , Pgm1
trehalose degradation pathwayGck , Slc2a2
triosephosphate isomerase deficiency pathwayAldoa , Bpgm , Eno1 , Fbp1 , G6pc , Galm , Gapdh , Gpi , Hk2 , Pank1 , Pck1 , Pgam1 , Pgam2 , Pgm1 , Slc2a2 , Tpi1
tryptophan metabolic pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1
type 2 diabetes mellitus pathwayGck , Hk1 , Hk2 , Hk3 , Pklr , Slc2a2
tyrosine metabolic pathwayAdh4 , Adh5 , Adh6 , Adh7 , Aldh1a3 , Aldh3a1 , Aldh3b1
tyrosinemia type I pathwayAldh3a1
valine, leucine and isoleucine biosynthetic pathwayPdha1 , Pdha2 , Pdhb
valine, leucine and isoleucine degradation pathwayAldh1a1 , Aldh1a7 , Aldh1b1 , Aldh2 , Aldh3a2 , Aldh7a1 , Aldh9a1 , Dld
vitamin A deficiency pathwayAldh1a1
Phenotype Annotations Associated with Genes in the glycolysis pathway

References Associated with the glycolysis pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: