INSULIN RESPONSIVE FACILITATIVE SUGAR TRANSPORTER MEDIATED GLUCOSE TRANSPORT PATHWAY (PW:0000639)

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Description

Facilitative sugar transporter mediated glucose transport is carried out by group I and III members of the GLUT family. Of the three high affinity group I transporters, Slc2a4/Glut4 mediates the insulin-responsive uptake of glucose in the heart, skeletal muscle and adipose tissue. The Glut4 mediated pathway is essential for proper glucose homeostasis; its proceedings occur in a cell-specific manner. In the basal state Glut4 is found in specialized vesicles (glucose storage vesicles, GSV) that (r

Pathway Diagram:

Elsevier Inc. cytoskeletal rearrangements Arp2/3 complex motor proteins Rhoq activating complex Rac1 effectors GEFs for Rac1 GEFs for Rab proteins Rabs at GSV Tbc1d4 Rab targets Rhoq Tbc1d4 Rab family mediated signaling pathway glucose ---> glucose uptake: heart, skeletal muscle, adipose tissue Akt2 insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway Limk1 Ssh1 Rac1 Rho/Rac/Cdc42 mediated signaling pathway GEFs for Rab proteins --+> Tbc1d4 Rab targets Akt2 ---| Tbc1d4 GEFs for Rab proteins --+> Rabs at GSV Tbc1d4 Rab targets ---> Rabs at GSV Lnpep ---- Tbc1d4 Lnpep glucose Rhoq ---| Rab31 Gapvd1 Cfl1 Recycling Slc2a4 glucose uptake: heart, skeletal muscle, adipose tissue insulin signaling pathway Akt2 --+> Myo5a Akt2 ---| Stxbp4 Stxbp4 phosphatidylinositol 3-kinase-Akt signaling pathway Tbc1d4 ---| Tbc1d4 Rab targets Myo5a phosphatidylinositol 3-kinase-Akt signaling pathway --+> Rab family mediated signaling pathway Stx4 ---- Stxbp4 Stxbp4 ---| Stx4 GEFs for Rac1 --+> Rac1 Rac1 ---> Rac1 effectors insulin signaling pathway --+> Rhoq activating complex phosphatidylinositol 3-kinase-Akt signaling pathway --+> Rac1 Arp2/3 complex ---> actin cycling actin cycling Cfl1 ---> actin cycling Ssh1 --+> Cfl1 Limk1 ---| Cfl1 Rhoq activating complex --+> Rhoq Rhoq ---- Trip10 Trip10 Gapvd1 ---- Trip10 Vamp2 Snap23 Stxbp3 Gapvd1 --+> Rab31 Stx4 Rab31 Slc2a4 Rab31 ---| Slc2a4
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Genes in Pathway:

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insulin responsive facilitative sugar transporter mediated glucose transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 ARP2 actin related protein 2 homolog JBrowse link 14 104,338,486 104,375,840 RGD:10054052
G Actr3 ARP3 actin related protein 3 homolog JBrowse link 13 41,695,520 41,738,622 RGD:10054052
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:2306432
RGD:6484113
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2302395
RGD:6484113
RGD:2306432
RGD:2302397
G Arpc1a actin related protein 2/3 complex, subunit 1A JBrowse link 12 11,272,609 11,294,084 RGD:10054052
G Arpc1b actin related protein 2/3 complex, subunit 1B JBrowse link 12 11,252,300 11,265,849 RGD:10054052
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:10054052
G Arpc3 actin related protein 2/3 complex, subunit 3 JBrowse link 12 39,653,951 39,667,817 RGD:10054052
G Arpc4 actin related protein 2/3 complex, subunit 4 JBrowse link 4 145,330,457 145,340,985 RGD:10054052
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 13 70,174,970 70,183,879 RGD:10054052
G Asip agouti signaling protein JBrowse link 3 150,492,010 150,579,870 RGD:6484113
G Baiap2 BAI1-associated protein 2 JBrowse link 10 109,107,326 109,187,458 RGD:10053654
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:10053654
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:10054052
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:10053654
G Cyfip1 cytoplasmic FMR1 interacting protein 1 JBrowse link 1 114,258,773 114,347,138 RGD:10053654
G Dennd1c DENN domain containing 1C JBrowse link 9 9,976,015 9,982,349 RGD:10053653
G Dennd4a DENN domain containing 4A JBrowse link 8 70,293,355 70,406,675 RGD:10053653
G Dennd4b DENN domain containing 4B JBrowse link 2 189,626,922 189,642,732 RGD:10053653
G Dennd4c DENN domain containing 4C JBrowse link 5 105,100,081 105,195,634 RGD:10053653
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Gys1 glycogen synthase 1 JBrowse link 1 101,427,195 101,447,092 RGD:6484113
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6484113
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:6484113
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:10053654
G Kif3a kinesin family member 3a JBrowse link 10 38,918,705 38,953,958 RGD:10053654
G Kif5b kinesin family member 5B JBrowse link 17 54,181,416 54,219,048 RGD:10053654
G Limk1 LIM domain kinase 1 JBrowse link 12 25,036,630 25,070,538 RGD:10054052
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:2302393
RGD:6484113
RGD:2306436
G Myo1c myosin 1C JBrowse link 10 63,803,311 63,819,614 RGD:10053654
G Myo5a myosin VA JBrowse link 8 82,038,966 82,156,507 RGD:2302397
RGD:10053654
G Myo5b myosin Vb JBrowse link 18 70,426,865 70,729,985 RGD:10053654
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:10053654
G Plekhg4 pleckstrin homology and RhoGEF domain containing G4 JBrowse link 19 37,327,395 37,345,047 RGD:10053654
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:6484113
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A JBrowse link 4 41,171,486 41,212,116 RGD:6484113
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 JBrowse link 3 163,329,580 163,477,822 RGD:10053654
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Rab10 RAB10, member RAS oncogene family JBrowse link 6 27,668,387 27,721,120 RGD:2302393
RGD:10053653
RGD:2302397
RGD:2302395
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:2302395
RGD:2302397
G Rab13 RAB13, member RAS oncogene family JBrowse link 2 189,581,209 189,586,358 RGD:10053653
G Rab14 RAB14, member RAS oncogene family JBrowse link 3 14,373,270 14,395,357 RGD:2302393
RGD:2306295
RGD:2302397
RGD:2302395
G Rab2a RAB2A, member RAS oncogene family JBrowse link 5 21,632,654 21,696,721 RGD:2302393
RGD:2302397
RGD:2302395
G Rab3ip RAB3A interacting protein JBrowse link 7 59,927,486 59,971,518 RGD:10053653
G Rab4a RAB4A, member RAS oncogene family JBrowse link 19 56,585,598 56,613,078 RGD:2302395
RGD:2306268
RGD:2302397
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:2302395
G Rab8a RAB8A, member RAS oncogene family JBrowse link 16 19,355,047 19,376,776 RGD:2302393
RGD:2306295
RGD:2302397
RGD:2302395
G Rab8b RAB8B, member RAS oncogene family JBrowse link 8 72,641,680 72,714,646 RGD:2302397
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:10053654
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:10053654
G Rhoq ras homolog family member Q JBrowse link 6 10,533,151 10,568,582 RGD:6484113
RGD:10053654
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:2302393
RGD:6484113
RGD:2306268
RGD:2303167
RGD:2302397
RGD:2302395
G Snap23 synaptosome associated protein 23 JBrowse link 3 112,333,972 112,362,960 RGD:2302393
RGD:2302397
G Sorbs1 sorbin and SH3 domain containing 1 JBrowse link 1 259,373,921 259,502,108 RGD:10053654
G Ssh1 slingshot protein phosphatase 1 JBrowse link 12 48,403,184 48,447,964 RGD:10054052
G Stx4 syntaxin 4 JBrowse link 1 199,287,384 199,295,606 RGD:2302393
RGD:6484113
RGD:2302397
G Stxbp3 syntaxin binding protein 3 JBrowse link 2 211,595,763 211,638,756 RGD:2302393
RGD:2302397
G Stxbp4 syntaxin binding protein 4 JBrowse link 10 78,005,745 78,168,641 RGD:2302395
RGD:6484113
G Tbc1d1 TBC1 domain family member 1 JBrowse link 14 45,598,753 45,797,650 RGD:10053653
G Tbc1d4 TBC1 domain family, member 4 JBrowse link 15 85,927,978 86,105,829 RGD:2302393
G Tiam1 T-cell lymphoma invasion and metastasis 1 JBrowse link 11 29,931,083 30,061,173 RGD:10053654
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 9 9,689,214 9,702,353 RGD:6484113
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:2302393
RGD:6484113
RGD:2302397
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
altered insulin responsive facilitative sugar transporter mediated glucose transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:7248543
G Tbc1d4 TBC1 domain family, member 4 JBrowse link 15 85,927,978 86,105,829 RGD:7248544

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassARP2/3 complexactin debranching complex
ProteinRac1 effectorseffectors downstream of Rac1
Functional ClassGEFs for Rab proteinsGEFs for Rabs in Glut4 trafficking
Functional ClassGEFs for Rac1GEFs specific for Rac1
Functional Classmotor proteinskinesins and myosins in Glut4 translocation
ComplexRhoq activating complexprotein complex with a Rhoq GEF

Pathway Gene Annotations

Disease Annotations Associated with Genes in the insulin responsive facilitative sugar transporter mediated glucose transport pathway
Disease TermsGene Symbols
abdominal aortic aneurysmGys1
abdominal obesity-metabolic syndromePrkci
Aberrant Crypt FociGsk3b
acanthosis nigricansTbc1d4
acute kidney failureGsk3b , Ins2
Acute Liver FailureIns2
Acute Lung InjuryPak1
acute myeloid leukemiaCbl
acute myocardial infarctionGsk3b
acute promyelocytic leukemiaAkt1
adenomaIns2
AIDS Dementia ComplexInsr
AlbuminuriaIns2
Alzheimer's diseaseAkt1 , Baiap2 , Calm1 , Gsk3b , Ins2 , Insr , Pak1 , Slc2a4
amphetamine abuseAkt1 , Myo5b
amyotrophic lateral sclerosisAkt1 , Gsk3b
amyotrophic lateral sclerosis type 1Tiam1
Animal Disease ModelsAkt1
Animal Mammary NeoplasmsYwhaz
anti-basement membrane glomerulonephritisRapgef1
Aortic Valve, Calcification ofAkt1
asthmaKif3a
astrocytomaAkt1 , Akt2
atherosclerosisAkt1
atrial fibrillationMyo1c
attention deficit hyperactivity disorderBaiap2
autism spectrum disorderBaiap2 , Cyfip1 , Limk1
autistic disorderPrex1
autosomal dominant mental retardation 48Rac1
autosomal dominant non-syndromic intellectual disability 18Dennd4b , Rab13
autosomal recessive limb-girdle muscular dystrophy type 2NInsr
autosomal recessive polycystic kidney diseaseAkt1
B-Cell Chronic Lymphocytic LeukemiaCbl
basal cell carcinomaAsip
bipolar disorderAkt1 , Gsk3b , Ins2
bladder diseaseIns2
bladder urothelial carcinomaAkt1
bone development diseaseKif3a
brain compressionCfl1
Brain InjuriesActr2 , Akt1 , Gsk3b
brain ischemiaAkt1 , Pak1 , Ywhab
Brain NeoplasmsIqgap1
branched-chain keto acid dehydrogenase kinase deficiencyStx4
breast adenocarcinomaAkt1
breast cancerAkt1
Breast NeoplasmsAkt1 , Akt2 , Arpc2 , Cfl1 , Insr , Lnpep , Pak1 , Prkci , Stxbp4
BurnsGsk3b
cannabis abuseAkt1 , Calm1 , Calm2
carcinomaYwhaz
cardiac arrestAkt1 , Ins2
Cardiac FibrosisPak1
CardiomegalyAkt1 , Gsk3b , Pak1 , Prkcz , Rac1 , Slc2a4
cardiomyopathyAkt1 , Insr , Ywhah
CardiotoxicityRac1
cardiovascular system diseaseGys1
Carotid Artery InjuriesCbl
catecholaminergic polymorphic ventricular tachycardiaCalm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
Cell Transformation, NeoplasticRac1
Chemical and Drug Induced Liver InjuryActr3
childhood absence epilepsyYwhaz
ChloracneRab11a
choriocarcinomaInsr
Chromosome 13q Deletion SyndromeTbc1d4
chromosome 13q14 deletion syndromeTbc1d4
chronic kidney diseaseInsr
chronic myeloid leukemiaAkt1
Cocaine-Related DisordersCalm1 , Calm2 , Cfl1
cognitive disorderGsk3b , Ins2
Cognitive DysfunctionActr3
colon adenocarcinomaRac1
colon adenomaRac1
colon cancerAkt1
colon carcinomaAkt1
Colonic NeoplasmsAkt2 , Gsk3b
colorectal adenocarcinomaArpc2 , Gsk3b
colorectal cancerAkt1 , Rac1
Colorectal NeoplasmsActr2 , Actr3 , Akt1 , Akt2
Congenital AbnormalitiesMyo5a
congenital diaphragmatic herniaCbl , Insr
Congenital HyperinsulinismTbc1d4
congenital hypothyroidismArpc5
congenital stationary night blindnessDennd4a
congestive heart failureCbl , Gsk3b , Ins2 , Ppp1cc , Rac1 , Slc2a4
coronary artery diseaseAkt1
Cowden diseaseAkt1
Cowden Syndrome 6Akt1
Craniofacial AbnormalitiesKif3a
cryptorchidismCbl
cystic kidney diseaseIns2
degenerative disc diseaseCrk , Gsk3b
DehydrationYwhaz
Developmental DisabilitiesCbl , Kif5b
diabetes mellitusArpc3 , Asip , Ins2 , Insr , Kif5b , Ppp1r3a , Rac1
Diabetes Mellitus, Experimental Akt1 , Insr , Kif5b , Prkci , Slc2a4 , Ywhah
DIABETES MELLITUS, NONINSULIN-DEPENDENT, 5Tbc1d4
Diabetic CardiomyopathiesCfl1 , Ins2
diabetic encephalopathyGsk3b
diabetic ketoacidosisIns2 , Insr
Diabetic NephropathiesCfl1 , Gsk3b , Ins2 , Lnpep , Trip10
diabetic neuropathyInsr
diabetic retinopathyIns2
Diamond-Blackfan anemiaVamp2
diarrheaMyo5b
dilated cardiomyopathyRac1
disease of cellular proliferationAsip
disease of metabolismIns2
Donohue syndromeInsr
Down syndromeArpc4
Drug-Induced DyskinesiaGsk3b
dysostosisKif3a
dystoniaIns2 , Myo5a
EdemaIns2
endometrial carcinomaGsk3b
Endometrial NeoplasmsAkt2 , Gsk3b , Lnpep , Sfn
Endometrioid CarcinomasAkt1 , Lnpep
epilepsyAkt1
Esophageal NeoplasmsSfn
Experimental ArthritisAkt1 , Cbl , Gsk3b
Experimental Autoimmune Myasthenia GravisArpc5
Experimental LeukemiaCbl
Experimental Liver CirrhosisArpc1b , Ins2 , Iqgap1 , Myo1c , Myo5a , Rab8b , Rhoq , Snap23 , Ywhag , Ywhaz
familial adenomatous polyposisAkt1
familial hyperinsulinemic hypoglycemia 5Insr
familial hypertrophic cardiomyopathyCalm3
familial partial lipodystrophyAkt2
familial partial lipodystrophy type 3Ppp1r3a
Familial Prostate CancerDennd4b
fatty liver diseaseIns2
FibrosisAkt1
focal segmental glomerulosclerosisActr3
focal segmental glomerulosclerosis 6Myo1c
fragile X syndromeCyfip1
Gallbladder NeoplasmsActr3 , Cfl1
gastric adenocarcinomaAkt1
gastritisArpc1b
gastrointestinal stromal tumorKif3a
GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 9Stx4
genetic diseaseAkt2 , Calm2 , Cbl
gestational diabetesIns2 , Insr
Gilles de la Tourette syndromeBaiap2
glioblastoma multiformeActr3 , Akt1
glucose intoleranceIns2 , Insr
Glycogen Storage Disease 0, MuscleGys1
Griscelli syndrome type 1Myo5a
Griscelli syndrome type 3Myo5a
Growth DisordersCbl
head and neck squamous cell carcinomaAkt1 , Rac1
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseGsk3b
Hematologic NeoplasmsCbl
hepatitisIns2
hepatocellular carcinomaAkt1 , Akt2 , Iqgap1 , Rac1 , Sfn
Hereditary Hyperferritinemia with Congenital CataractsGys1
Hereditary Neoplastic SyndromesKif3a , Lnpep
hereditary spastic paraplegia 6Cyfip1
Huntington's diseaseTrip10
HyperalgesiaCfl1 , Insr , Prkcz
hyperglycemiaCbl , Ins2 , Insr , Prkcz
hyperinsulinismIns2 , Insr
HyperkalemiaIns2
HyperplasiaAkt1
HyperproinsulinemiaIns2
hypertensionAkt1 , Akt2 , Gsk3b , Ins2 , Ywhaz
Hypertensive NephropathyCfl1
HypertriglyceridemiaIns2
hypertrophic cardiomyopathyIns2
hyperuricemiaIns2
hypoglycemiaAkt2 , Ins2 , Ppp1r3a
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypokalemiaIns2
HypotensionIns2
impotenceAkt1 , Cfl1
in situ carcinomaAkt1 , Sfn
infantile epileptic encephalopathy 56Ywhag
InflammationAkt1
inherited metabolic disorderMyo5b
Insulin ResistanceAkt2 , Gys1 , Ins2 , Insr , Ppp1r3a , Prkcz , Slc2a4 , Sorbs1
Insulin-Resistant Diabetes Mellitus, with Acanthosis NigricansInsr
insulinomaIns2
intermediate coronary syndromeAkt1
Intervertebral Disc DisplacementAkt1
intestinal diseaseMyo5b
Intestinal NeoplasmsGsk3b
invasive ductal carcinomaAkt1
ischemiaAkt2
juvenile myelomonocytic leukemiaCbl
KeloidSfn
kidney failureIns2
Kidney NeoplasmsAkt1
Left Ventricular HypertrophyPrkcz , Rac1
left ventricular noncompactionYwhae
leiomyomaLnpep
leukemiaPrkcz
Lewy body dementiaIns2 , Insr
lipoatrophic diabetes mellitusInsr
lipodystrophyInsr
liver benign neoplasmAsip , Myo5b
liver cancerAkt1
liver diseaseIns2 , Rac1
Liver Reperfusion InjuryGsk3b
long QT syndromeAsip
long QT syndrome 1Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
lung adenocarcinomaAkt1
lung diseaseInsr
Lung NeoplasmsAkt1
lung small cell carcinomaAkt1
lung squamous cell carcinomaAkt1 , Arpc5
Lymphatic MetastasisPrex1 , Sfn
lymphopeniaCbl
major depressive disorderCalm2
male infertilityCbl
malignant gliomaAkt2
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Gsk3b , Lnpep , Ywhaz
mantle cell lymphomaGsk3b
maturity-onset diabetes of the youngIns2
maturity-onset diabetes of the young type 10Ins2
melanomaAkt1 , Arpc2 , Asip , Cbl , Rac1
Memory DisordersIns2 , Lnpep
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionGsk3b
mesangial proliferative glomerulonephritisRapgef1
Metabolic SyndromeIns2
Micronuclei, Chromosome-DefectiveIns2
Microphthalmia, Syndromic 1Myo1c
microvillus inclusion diseaseMyo5b
middle cerebral artery infarctionGsk3b
Miller-Dieker lissencephaly syndromeYwhae
Monoclonal B-Cell LymphocytosisRapgef1
Mouth NeoplasmsSfn , Tiam1
MPTP PoisoningIns2
Multiple AbnormalitiesGsk3b
multiple myelomaCbl
muscular atrophyAkt1 , Cfl1 , Gsk3b
muscular diseaseIns2
myelodysplastic syndromeArpc1b
myeloid neoplasmCbl
myocardial infarctionAkt1 , Cfl1 , Gsk3b
Myocardial IschemiaCrk , Rab5a , Snap23
Myocardial Reperfusion InjuryAkt1 , Akt2 , Cbl , Gsk3b , Slc2a4
nemaline myopathy 6Dennd4a , Rab11a , Rab8b
NeointimaIqgap1 , Pak1 , Ssh1
neonatal diabetes mellitusIns2
Neoplasm InvasivenessCfl1
Neoplasm MetastasisAkt2 , Cfl1 , Rac1 , Ywhae
Neoplasm Recurrence, LocalYwhaz
nephroblastomaPak1
Nephrosis, Puromycin AminonucleosideActr2 , Baiap2
nephrotic syndromeCfl1
neural tube defectIns2
NeuralgiaCfl1
neurodegeneration with brain iron accumulation 3Gys1
neuronal ceroid lipofuscinosis 6Gsk3b
non-small cell lung carcinomaAkt1 , Akt2 , Arpc5 , Cbl , Kif5b
Noonan Like SyndromeCbl
Noonan syndromeCbl
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
obesityAkt1 , Akt2 , Asip , Ins2 , Prkci , Sorbs1 , Tbc1d1
opisthorchiasisActr3
Optic Nerve InjuriesCfl1
oral squamous cell carcinomaArpc1b
osteoarthritisIns2 , Ywhaq
osteosarcomaAkt1
ovarian cancerAkt1
Ovarian NeoplasmsAkt1 , Akt2 , Gsk3b , Lnpep , Pak1 , Ppp1cc , Prkci , Sfn
PainAkt1
pancreatic cancerAkt1 , Akt2 , Arpc1a , Ins2
pancreatic ductal carcinomaIns2
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisIns2
panic disorderIns2
ParalysisIns2
paraplegiaAkt1
ParesthesiaIns2
Parkinson's diseaseAkt1 , Arpc3 , Gsk3b , Ins2 , Insr
peripheral nervous system diseaseMyo5a
peritonitisGsk3b
permanent neonatal diabetes mellitusIns2
Phelan-McDermid syndromeIns2
phencyclidine abuseCalm1 , Calm2
pigmentation diseaseAsip
PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASEArpc1b
pleomorphic xanthoastrocytomaArpc1a , Arpc1b , Limk1 , Ppp1r3a , Ywhag
PoisoningGsk3b
polycystic kidney disease 1Kif3a
polycystic ovary syndromeAkt2 , Ins2 , Rab2a
polydactylyKif3a
polyhydramniosLnpep
Prader-Willi-Like SyndromeCyfip1
pre-malignant neoplasmAkt1 , Cfl1 , Insr
prostate adenocarcinomaAkt1 , Akt2 , Insr
prostate cancerAkt2 , Ins2 , Sorbs1
prostate carcinomaAkt2
Prostatic NeoplasmsAkt1 , Gsk3b , Ins2 , Insr , Prex1 , Prkcz , Stx4
proteinuriaPak1
Proteus syndromeAkt1
pulmonary hypertensionSlc2a4
RASopathiesCbl
renal cell carcinomaAkt1 , Insr , Lnpep , Pak1
Reperfusion InjuryAkt1
RhabdomyolysisIns2
rheumatoid arthritisRab8a
Right Ventricular HypertrophyAkt1
schizophreniaActr3 , Akt1 , Arpc1a , Arpc1b , Cyfip1 , Gsk3b , Pak1 , Ywhah , Ywhaz
sciatic neuropathyGsk3b
Segawa Syndrome, Autosomal RecessiveIns2
seminomaInsr
SepsisGsk3b
short bowel syndromeInsr
silicosisArpc2
skin melanomaAkt1 , Rac1
Skin NeoplasmsAkt1 , Asip
Skin/Hair/Eye Pigmentation, Variation In, 9Asip
Smith-Magenis syndromeBaiap2 , Stxbp4
spina bifidaCfl1
Spinal Cord InjuriesAkt1 , Ppp1cc
spinocerebellar ataxia type 31Plekhg4
squamous cell carcinomaAkt1 , Sfn , Tiam1
status epilepticusCfl1 , Gsk3b
stomach cancerArpc1b
StrokeAkt1 , Pak1
Subarachnoid HemorrhageGsk3b
substance-induced psychosisAkt1
substance-related disorderGsk3b , Insr
systemic lupus erythematosusYwhab
systemic sclerodermaArpc2
T-Cell LymphomaAkt1
TachycardiaGsk3b , Ins2
tauopathyGsk3b
temporal lobe epilepsyCyfip1
Thyroid NeoplasmsAkt1 , Akt2
transient cerebral ischemiaCbl
transitional cell carcinomaAkt1 , Pak1 , Sfn
type 1 diabetes mellitusCbl , Ins2
type 1 diabetes mellitus 2Ins2
type 2 diabetes mellitusAkt1 , Akt2 , Asip , Calm1 , Gsk3b , Ins2 , Insr , Lnpep , Ppp1r3a , Prkci , Prkcz , Slc2a4 , Sorbs1
ulcerative colitisArpc2
ureteral obstructionAkt1 , Cfl1
urinary bladder cancerAkt1 , Sfn
Uterine Cervical NeoplasmsAkt1
Uterine NeoplasmsRac1
vascular dementiaGsk3b
Vascular System InjuriesIqgap1
vasculitisCbl
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftIns2 , Rac1
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
visual epilepsyIns2 , Kif5b , Myo5a , Ywhab , Ywhaz
vitamin B12 deficiencyCfl1
Vulvar NeoplasmsSfn
Weight GainCalm1 , Iqgap1
Weight LossIns2
Weissenbacher-Zweymuller syndromeSlc2a4
West syndromeCfl1
Williams-Beuren syndromeLimk1
Pathway Annotations Associated with Genes in the insulin responsive facilitative sugar transporter mediated glucose transport pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1
acute myeloid leukemia pathwayAkt1 , Akt2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3
adenosine signaling pathwayAkt1 , Pak1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1
aldosterone signaling pathwayIns2 , Insr , Sfn
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2 , Tbc1d4
altered insulin signaling pathwayIns2 , Insr
altered leptin system pathwayInsr
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2
Alzheimer's disease pathwayCalm1 , Calm2 , Calm3 , Gsk3b
amiodarone pharmacodynamics pathwayCalm1
amlodipine pharmacodynamics pathwayCalm1
amyotrophic lateral sclerosis pathwayRab5a , Rac1
angiotensin II signaling pathwayPrkcz
angiotensin IV signaling pathwayLnpep
apoptotic cell death pathwayAkt1 , Akt2
Arf family mediated signaling pathwayRac1
atenolol pharmacodynamics pathwayCalm1
auditory mechanotransduction pathwayMyo1c
autophagy pathwayIns2 , Rab11a , Rab5a
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Gsk3b , Rac1
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayCalm1
bisoprolol pharmacodynamics pathwayCalm1
Bone morphogenetic proteins signaling pathwayGsk3b
brain-derived neurotrophic factor signaling pathwayTiam1
bupranolol drug pathwayCalm1
bupranolol pharmacodynamics pathwayCalm1
c-Jun N-terminal kinases MAPK signaling pathwayRac1 , Rapgef1
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
carvedilol pharmacodynamics pathwayCalm1
cell cycle pathway, mitoticGsk3b , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Prkcz , Rac1
Chagas disease pathwayAkt1 , Akt2
chemokine mediated signaling pathwayAkt1 , Akt2 , Crk , Gsk3b , Pak1 , Prex1 , Prkcz , Rac1 , Tiam1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Cbl , Crk
colorectal cancer pathwayAkt1 , Akt2 , Gsk3b , Rac1
diltiazem pharmacodynamics pathwayCalm1
disopyramide pharmacodynamics pathwayCalm1
dobutamine pharmacodynamics pathwayCalm1
dopamine signaling pathwayPpp1cc
E-cadherin signaling pathwayAkt1 , Akt2 , Crk , Iqgap1 , Rac1 , Stx4 , Tiam1
eicosanoid signaling pathwayAkt1 , Prkcz , Rab11a , Rac1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaSorbs1
endocytosis pathwayCbl , Prkci , Prkcz , Rab11a , Rab4a , Rab5a
endometrial cancer pathwayAkt1 , Akt2 , Gsk3b
endothelin signaling pathwayAkt1 , Crk , Rac1
Entamoebiasis pathwayRab5a
ephrin - ephrin receptor bidirectional signaling axisCbl , Crk , Pak1 , Rac1 , Tiam1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Cbl , Crk , Gsk3b , Pak1 , Prkcz
erythropoietin signaling pathwayCbl
esmolol pharmacodynamics pathwayCalm1
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
FasL mediated signaling pathwayAkt1
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Rac1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Arpc1a , Arpc1b , Arpc2 , Arpc3 , Arpc4 , Arpc5 , Cfl1 , Crk , Limk1 , Pak1 , Rac1
fibroblast growth factor signaling pathwayAkt1 , Cbl , Ssh1
flecainde pharmacodynamics pathwayCalm1
forkhead class A signaling pathwayAkt1 , Ins2
fosphenytoin pharmacodynamics pathwayCalm1
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3
glyburide pharmacodynamics pathwayIns2
glycogen biosynthetic pathwayGsk3b , Gys1 , Ppp1cc , Ppp1r3a
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , Ppp1cc , Ppp1r3a
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3
granulocyte-macrophage colony-stimulating factor signaling pathwayYwhaz
Hedgehog signaling pathwayAkt1 , Gsk3b , Kif3a
hepatitis C pathwayAkt1 , Akt2 , Gsk3b
histone modification pathwayYwhaz
hypoxia inducible factor pathwayAkt1
ibutilide pharmacodynamics pathwayCalm1
influenza A pathwayAkt1 , Akt2 , Gsk3b
insulin responsive facilitative sugar transporter mediated glucose transport pathwayActr2 , Actr3 , Akt1 , Akt2 , Arpc1a , Arpc1b , Arpc2 , Arpc3 , Arpc4 , Arpc5 , Asip , Baiap2 , Calm1 , Calm2 , Calm3 , Cbl , Cfl1 , Crk , Cyfip1 , Dennd1c , Dennd4a , Dennd4b , Dennd4c , Gsk3b , Gys1 , Ins2 , Insr , Iqgap1 , Kif3a , Kif5b , Limk1 , Lnpep , Myo1c , Myo5a , Myo5b , Pak1 , Plekhg4 , Ppp1cc , Ppp1r3a , Prex1 , Prkci , Prkcz , Rab10 , Rab11a , Rab13 , Rab14 , Rab2a , Rab3ip , Rab4a , Rab5a , Rab8a , Rab8b , Rac1 , Rapgef1 , Rhoq , Sfn , Slc2a4 , Snap23 , Sorbs1 , Ssh1 , Stx4 , Stxbp3 , Stxbp4 , Tbc1d1 , Tbc1d4 , Tiam1 , Trip10 , Vamp2 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin secretion pathwayVamp2
insulin signaling pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Cbl , Crk , Gsk3b , Gys1 , Ins2 , Insr , Ppp1cc , Ppp1r3a , Prkci , Prkcz , Rapgef1 , Rhoq , Slc2a4 , Sorbs1 , Trip10
insulin-like growth factor signaling pathwayAkt1 , Crk , Prkcz , Ywhae , Ywhaz
interleukin-1 signaling pathwayPrkci , Prkcz
interleukin-3 signaling pathwayYwhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Cbl
interleukin-6 signaling pathwayAkt1 , Rac1
isoprenaline pharmacodynamics pathwayCalm1
isradipine pharmacodynamics pathwayCalm1
Jak-Stat signaling pathwayAkt1 , Akt2 , Cbl
levobunolol pharmacodynamics pathwayCalm1
lidocaine pharmacodynamics pathwayCalm1
long term depressionGsk3b
long term potentiationCalm1 , Calm2 , Calm3 , Lnpep , Ppp1cc
maturity-onset diabetes of the young pathwayIns2
measles pathwayAkt1 , Akt2 , Gsk3b
melanocortin system pathwayAsip
melanoma pathwayAkt1 , Akt2
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
metoprolol pharmacodynamics pathwayCalm1
mexiletine pharmacodynamics pathwayCalm1
mitochondria transport pathwayKif5b
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Crk , Pak1 , Rac1
mTOR signaling pathwayAkt1 , Akt2 , Ins2 , Rac1 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
myocarditis pathwayRac1
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Kif5b , Rac1
nadolol pharmacodynamics pathwayCalm1
nebivolol pharmacodynamics pathwayCalm1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Crk , Gsk3b , Rac1 , Rapgef1 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
nifedipine pharmacodynamics pathwayCalm1
nimodipine pharmacodynamics pathwayCalm1
nisoldipine pharmacodynamics pathwayCalm1
nitrendipine pharmacodynamics pathwayCalm1
non-small cell lung carcinoma pathwayAkt1 , Akt2
Notch signaling pathwayCbl , Rab11a
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3 , Rac1
p53 signaling pathwayAkt1 , Gsk3b , Sfn
pancreatic cancer pathwayAkt1 , Akt2 , Rac1
penbutolol pharmacodynamics pathwayCalm1
phagocytosis pathwayRab5a , Rac1
phenytoin pharmacodynamics pathwayCalm1
phosphatidylinositol 3-kinase class I signaling pathwayRac1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Gsk3b , Sfn , Slc2a4 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
pindolol pharmacodynamics pathwayCalm1
platelet-derived growth factor signaling pathwayActr2 , Actr3 , Arpc1b , Arpc2 , Arpc3 , Arpc5 , Baiap2 , Cbl , Crk , Iqgap1 , Pak1 , Rab4a , Rac1 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
potassium channel inhibitors pharmacodynamics pathwayIns2
procainamide pharmacodynamics pathwayCalm1
propranolol pharmacodynamics pathwayCalm1
prostate cancer pathwayAkt1 , Akt2 , Gsk3b , Ins2
protein kinase C (PKC) signaling pathwayPrkci , Prkcz
quinidine pharmacodynamics pathwayCalm1
Rab family mediated signaling pathwayActr2 , Actr3 , Arpc1a , Arpc1b , Arpc2 , Arpc3 , Arpc4 , Arpc5 , Cfl1 , Dennd1c , Dennd4a , Dennd4b , Dennd4c , Limk1 , Rab10 , Rab11a , Rab13 , Rab14 , Rab2a , Rab3ip , Rab4a , Rab5a , Rab8a , Rab8b , Ssh1 , Tbc1d1 , Tbc1d4
Reelin signaling pathwayAkt1 , Cbl , Gsk3b
renal cell carcinoma pathwayAkt1 , Akt2 , Crk , Pak1 , Rac1 , Rapgef1
renin-angiotensin cascade pathwayLnpep
Rho/Rac/Cdc42 mediated signaling pathwayBaiap2 , Cbl , Crk , Cyfip1 , Iqgap1 , Pak1 , Plekhg4 , Prex1 , Rac1 , Rapgef1 , Rhoq , Sorbs1 , Tiam1
scatter factor/hepatocyte growth factor signaling pathwayCbl
small cell lung carcinoma pathwayAkt1 , Akt2
sotalol pharmacodynamics pathwayCalm1
sphingosine 1-phosphate signaling pathwayAkt1 , Pak1 , Rac1
starch and sucrose metabolic pathwayGys1
syndecan signaling pathwayRac1
T cell receptor signaling pathwayAkt1 , Akt2 , Cbl , Gsk3b , Pak1
timolol pharmacodynamics pathwayCalm1
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Akt2 , Rac1
toxoplasmosis pathwayAkt1 , Akt2
transforming growth factor-beta Smad dependent signaling pathwayYwhae
tuberculosis pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Rab5a
tumor necrosis factor mediated signaling pathwayPrkci , Prkcz
type 1 diabetes mellitus pathwayIns2
type 2 diabetes mellitus pathwayAkt2 , Ins2 , Insr , Prkcz , Slc2a4
type II interferon signaling pathwayAkt1 , Calm1 , Calm2 , Calm3 , Cbl
ubiquitin/proteasome degradation pathwayCbl
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Calm1 , Calm2 , Calm3 , Cbl , Iqgap1 , Prkcz , Rac1
vasopressin signaling pathwayMyo5b , Rab11a , Snap23 , Vamp2
vasopressin signaling pathway via receptor type 2Myo5b , Rab11a , Rab5a , Snap23 , Stx4 , Vamp2
verapamil pharmacodynamics pathwayCalm1
visual phototransduction pathwayCalm1 , Calm2 , Calm3
Wnt signaling pathwayGsk3b , Rac1
Wnt signaling, canonical pathwayGsk3b
Wnt signaling, non-canonical pathwayPrkcz , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the insulin responsive facilitative sugar transporter mediated glucose transport pathway

References Associated with the insulin responsive facilitative sugar transporter mediated glucose transport pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: