ALTERED TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000614)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The transforming growth factor-beta (Tgf-b) Smad-dependent pathway is one of the best characterized modules of the Tgf-b superfamily signaling. Deregulation of Tgf-b Smad-dependent signaling renders the otherwise tumor-suppressive and growth-inhibitory pathway, a pro-growth and pro-tumorige

Pathway Diagram:

Ariadne Genomics Inc. Tgf-beta target genes Transcription factors/co-activators colorectal cancer pathway Colorectal Neoplasms Pancreatic Neoplasms Prostatic Neoplasms Smad7 Smurf2 Tgf-beta target genes ---> Colorectal Neoplasms Smad3 Smad2 Smad7 ---| Tgfbr1 Fkbp1a Zfyve9 Dcn A2m Tgfbr3 Smad3 ---- Zfyve9 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Smad7 ---| Tgfbr1 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgf-beta target genes ---> Smad7 Smurf1 Smad4 Tgf-beta target genes ---> colorectal cancer pathway Tgf-beta target genes ---> Pancreatic Neoplasms Translocated Smad ---> Tgf-beta target genes Tgfbr2 Tgfb1 ---- Tgfbr2 Tgfb1 Tgfbr1 Tgfb1 ---- Tgfbr1 Tgf-beta target genes ---> Prostatic Neoplasms Translocated Smad
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Genes in Pathway:

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altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490966
RGD:5490965

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaycolorectal cancer pathwayColorectal cancer are malignant tumors of the colon and rectum
Gene Grouptranscription factors/co-activatorstranscription factors/co-activators associated with Smad2/3-4
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
Abortion, SpontaneousTgfb1 , Tgfbr1
Acro-OsteolysisSmad4
Acromicric DysplasiaSmad2 , Tgfb1
actinic keratosisTgfb1
acute kidney failureTgfb1
Acute Lung InjuryTgfb1
adenocarcinomaTgfb1
alcoholic liver cirrhosisSmad3 , Tgfb1
allergic conjunctivitisTgfb1
allergic hypersensitivity diseaseTgfb1
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
aortic aneurysmSmad3 , Tgfbr1 , Tgfbr2
aortic diseaseSmad3 , Smad4
aortic valve insufficiencyTgfb1
aplastic anemiaTgfb1
ARTERIAL DISSECTIONSmad3
arteriosclerosisTgfb1 , Tgfbr2
asthmaTgfb1
atopic dermatitisTgfb1
atrial fibrillationSmad7
autoimmune hepatitisTgfb1
autoimmune thrombocytopenic purpuraTgfb1
Behcet's diseaseTgfb1
berylliosisTgfb1
bone diseaseTgfbr2
Bone FracturesTgfbr2
Bone NeoplasmsTgfbr2
brachydactylySmad4
brain diseaseTgfb1
brain ischemiaTgfb1
Brain NeoplasmsTgfbr2
breast cancerSmad4 , Tgfb1
breast carcinomaSmad2
Breast NeoplasmsSmad4
CachexiaTgfb1
calcinosisTgfb1
Camurati-Engelmann diseaseTgfb1
carcinomaTgfb1 , Tgfbr2
carcinosarcomaTgfb1
Cardiac FibrosisTgfb1
CardiomegalyTgfb1
carotid artery diseaseTgfb1
Cell Transformation, NeoplasticTgfb1
cervical cancerSmad2 , Smad4
Chemical and Drug Induced Liver InjuryTgfbr1
cholangiocarcinomaSmad4 , Tgfb1 , Tgfbr2
chorioamnionitisTgfb1
Chronic HepatitisSmad2 , Tgfb1
chronic myeloid leukemiaSmad4 , Tgfb1
chronic obstructive pulmonary diseaseSmad4 , Tgfb1
CicatrixSmad4
cleft palateTgfb1
cleft soft palateTgfbr2
Cocaine-Related DisordersSmad3
cognitive disorderSmad4
colon adenocarcinomaTgfb1
colon cancerTgfbr2
colon carcinomaTgfb1
Colonic NeoplasmsTgfbr2
colorectal cancerSmad4 , Smad7 , Tgfb1
Colorectal NeoplasmsSmad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1
connective tissue diseaseSmad3 , Tgfbr1 , Tgfbr2
Copper-Overload CirrhosisSmad2 , Tgfb1
coronary artery diseaseTgfb1
Craniofacial AbnormalitiesSmad2 , Smad3 , Smad4 , Tgfbr2
Crohn's diseaseSmad3
Cronkhite-Canada syndromeSmad4
cystic fibrosisTgfb1
DeafnessSmad4
degenerative disc diseaseTgfb1
Diabetes Mellitus, Experimental Tgfb1
Diabetic NephropathiesTgfb1 , Tgfbr2
diabetic neuropathyTgfb1
Diaphragmatic HerniaTgfb1
DiGeorge syndromeTgfbr2
Dilatation, PathologicTgfb1
Dissecting AneurysmSmad3 , Tgfbr1 , Tgfbr2
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
duodenal ulcerTgfb1
Ehlers-Danlos syndromeTgfb1
end stage renal failureTgfb1
endometrial cancerSmad2 , Smad3 , Smad7
endometrial carcinomaSmad4
endomyocardial fibrosisTgfb1
eosinophilic esophagitisTgfb1
epilepsyTgfb1
esophageal cancerTgfbr2
esophageal carcinomaSmad4
Esophageal NeoplasmsTgfbr2
esophagus adenocarcinomaSmad4
essential thrombocythemiaTgfb1
Experimental ArthritisTgfbr2
Experimental Autoimmune EncephalomyelitisTgfb1
Experimental ColitisSmad4
Experimental Liver CirrhosisSmad2 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Experimental Liver NeoplasmsTgfb1
extrahepatic cholestasisTgfb1
Eye AbnormalitiesTgfbr2
factor VIII deficiencyTgfb1
familial hyperlipidemiaTgfb1
Familial Thoracic Aortic Aneurysm 1Smad3 , Tgfbr2
Familial Thoracic Aortic Aneurysm 3Tgfbr2
FatigueTgfbr2
Ferguson-Smith tumorTgfbr1
FibrosisTgfb1
focal segmental glomerulosclerosisTgfb1
Gallbladder NeoplasmsTgfb1
gastric adenocarcinomaSmad4
gastrointestinal stromal tumorTgfbr2
gastrointestinal system cancerSmad4
genetic diseaseSmad2 , Smad4 , Tgfbr2
Growth Mental Deficiency Syndrome of MyhreSmad4
head and neck squamous cell carcinomaSmad4
heart diseaseTgfb1
Hepatic InsufficiencyTgfb1
hepatocellular carcinomaSmad2 , Smad4 , Tgfb1 , Tgfbr2
HepatomegalyTgfb1
hereditary hemorrhagic telangiectasiaSmad4
Hereditary Hemorrhagic Telangiectasia, Type 1Smad4 , Tgfb1
Hereditary Neoplastic SyndromesSmad4
hereditary nonpolyposis colorectal cancer type 6Tgfbr2
HyperoxiaTgfb1
HyperplasiaTgfb1 , Tgfbr2
hypertensionTgfb1
hypertrophic cardiomyopathyTgfb1
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
IgA glomerulonephritisTgfb1
impotenceTgfb1
Infant, Newborn, DiseasesTgfb1
InflammationTgfb1
inflammatory bowel diseaseTgfb1
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHYTgfb1
inguinal herniaTgfbr2
insulinomaTgfb1
interstitial lung diseaseTgfb1
invasive ductal carcinomaSmad4
juvenile polyposis syndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
juvenile rheumatoid arthritisSmad3
kidney diseaseTgfb1 , Tgfbr1 , Tgfbr2
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
leiomyomaSmad3 , Tgfbr1
Lipoyltransferase 1 DeficiencyTgfbr2
liver cirrhosisSmad3 , Tgfb1 , Tgfbr1
localized sclerodermaTgfb1
Loeys-Dietz syndromeSmad3 , Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 1Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 2Tgfbr2
Loeys-Dietz syndrome 3Smad3
Loeys-Dietz Syndrome, Type 1bTgfbr2
lung adenocarcinomaSmad4
lung diseaseTgfb1
Lung NeoplasmsTgfb1 , Tgfbr2
Lymphatic MetastasisSmad4
Lynch syndromeSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Mammary Neoplasms, ExperimentalTgfb1 , Tgfbr1 , Tgfbr2
Marfan syndromeTgfbr2
membranoproliferative glomerulonephritisTgfbr2
Metabolic SyndromeTgfb1
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityTgfbr2
migraineTgfbr2
Multiple AbnormalitiesSmad2
multiple myelomaTgfb1
muscular diseaseSmad4 , Tgfb1
myelofibrosisTgfb1
myocardial infarctionSmad2 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Myocardial Reperfusion InjurySmad3 , Smad4 , Tgfb1
Nasal PolypsTgfb1
Neoplasm InvasivenessTgfb1
Neoplasm MetastasisTgfb1 , Tgfbr1 , Tgfbr2
nephritisSmad7
nephrolithiasisTgfb1
nephrotic syndromeTgfb1
NeuralgiaTgfb1
neuronal ceroid lipofuscinosis 8Tgfbr2
nonalcoholic fatty liver diseaseTgfb1
obesityTgfb1
Occupational AsthmaTgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
oral submucous fibrosisTgfb1
Ossification, HeterotopicSmad4
osteoarthritisSmad3 , Tgfb1
Osteoarthritis, HipSmad3
osteochondrodysplasiaTgfb1 , Tgfbr1
osteogenesis imperfectaSmad4
osteoporosisTgfb1
ovarian cancerSmad2 , Smad4
ovarian carcinomaSmad2
Ovarian NeoplasmsSmad7
pancreatic adenocarcinomaSmad4
pancreatic cancerSmad3 , Smad4 , Tgfb1 , Tgfbr2
pancreatic carcinomaSmad4
pancreatic ductal carcinomaTgfb1 , Tgfbr2
papillomaTgfb1
Paraquat LungSmad7 , Tgfb1
Parasitic Liver DiseasesSmad4
Peritoneal FibrosisTgfb1
Peyronie's diseaseTgfb1
pleural diseaseTgfb1
pneumoniaTgfb1
Posterior Leukoencephalopathy SyndromeTgfb1
Postmenopausal OsteoporosisTgfb1
pre-malignant neoplasmSmad3 , Smad4
primary biliary cirrhosisTgfb1
primary pulmonary hypertensionSmad4
prostate adenocarcinomaSmad4
prostate cancerSmad3 , Tgfb1 , Tgfbr2
prostate carcinoma in situSmad4
Prostatic NeoplasmsSmad4 , Tgfb1 , Tgfbr2
prostatitisSmad4
proteinuriaTgfb1
psoriasisTgfb1
pulmonary emphysemaTgfb1
pulmonary fibrosisSmad4 , Smad7 , Tgfb1 , Tgfbr2
pulmonary hypertensionSmad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
pulmonary sarcoidosisTgfb1
Radiation InjuriesTgfbr2
Radiation PneumonitisTgfb1
renal cell carcinomaSmad2 , Smad4 , Tgfb1
Reperfusion InjuryTgfbr2
rhinitisTgfb1
Right Ventricular HypertrophyTgfb1
sarcoidosisTgfb1
scimitar syndromeSmad2
seminomaSmad4
SepsisTgfb1
sickle cell anemiaTgfb1
Sjogren's syndromeTgfb1
Skin NeoplasmsTgfb1 , Tgfbr1
Spinal Cord InjuriesTgfb1
squamous cell carcinomaTgfb1
Stomach NeoplasmsSmad4
StrokeTgfb1
systemic sclerodermaTgfbr1
thoracic aortic aneurysmSmad3 , Tgfbr1 , Tgfbr2
thrombocytopeniaTgfb1
tracheal stenosisTgfb1
transitional cell carcinomaSmad4
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeSmad4
type 1 diabetes mellitusTgfb1
type 2 diabetes mellitusSmad4 , Tgfb1 , Tgfbr2
uremiaTgfb1 , Tgfbr1
ureteral obstructionSmad3 , Tgfb1
urethral obstructionTgfb1
urinary bladder cancerSmad2 , Smad4 , Tgfbr1
urticariaTgfb1
Uterine Cervical NeoplasmsSmad4
Uterine NeoplasmsSmad3
uveitisTgfb1
vasculogenic impotenceTgfbr2
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
vitiligoTgfb1
Wallerian DegenerationTgfb1
Wolff-Parkinson-White syndromeTgfbr2
Wounds and InjuriesTgfb1
Pathway Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Bone morphogenetic proteins signaling pathwaySmad4 , Smad7
cell cycle pathway, mitoticSmad2 , Smad3 , Smad4 , Tgfb1
ceramide signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
Chagas disease pathwaySmad2 , Smad3 , Tgfb1 , Tgfbr1 , Tgfbr2
chronic myeloid leukemia pathwaySmad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
colorectal cancer pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
cytokine mediated signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1
endocytosis pathwaySmad2 , Smad3 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Entamoebiasis pathwayTgfb1
glypican signaling pathwaySmad2 , Tgfb1 , Tgfbr2
hypertrophic cardiomyopathy pathwayTgfb1
hypoxia inducible factor pathwaySmad3 , Smad4
interleukin-27 signaling pathwayTgfb1
Leishmaniasis pathwayTgfb1
malaria pathwayTgfb1
mitogen activated protein kinase signaling pathwayTgfb1 , Tgfbr1 , Tgfbr2
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
renal cell carcinoma pathwayTgfb1
rheumatoid arthritis pathwayTgfb1
syndecan signaling pathwayTgfb1
toxoplasmosis pathwayTgfb1
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
tuberculosis pathwayTgfb1
type II interferon signaling pathwaySmad7
Wnt signaling pathwaySmad2 , Smad3 , Smad4
Phenotype Annotations Associated with Genes in the altered transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
liver fibrosisSmad3

References Associated with the altered transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

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