COLORECTAL CANCER PATHWAY (PW:0000612)

View Ontology Report

Description

Colorectal cancer (CRC) affects both men and women and is a rather prevalent condition in the Western world. A number of pathways are known to be altered in CRC; they include the canonical Wnt, transforming growth factor-beta, Smad dependent and the extracellular signal-regulated Raf/Mek/Erk signaling pathways and the regulatory DNA mismatch repair pathway. While mutations in components of some of these pathways may be implicated in other forms of cancer and/or types of diseases, the diagram dep

Pathway Diagram:

Elsevier Inc. cisplatin_DNA_adducts ---| Colorectal Neoplasms Axin2 Ctnnb1 Axin1 Apc altered Wnt signaling, canonical pathway Tgfbr2 Tgfbr1 Tgfb1 Smad3 Smad4 Smad2 altered transforming growth factor-beta Smad dependent signaling pathway upregulated miRNA ---> downregulated target translation upregulated target translation downregulated target translation cisplatin_DNA_adducts abnormal Watson-Crick pairing Mlh1 Msh2 Msh6 Pms1 Pms2 altered mismatch repair pathway altered expression of target genes potential CRC miRNA ---> Colorectal Neoplasms downregulated miRNA ---> upregulated target translation cisplatin drug pathway Braf Kras altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered mismatch repair pathway ---> abnormal Watson-Crick pairing altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes potential CRC miRNA upregulated miRNA downregulated miRNA cisplatin drug pathway ---> cisplatin_DNA_adducts Colorectal Neoplasms
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
colorectal cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
RGD:6907045
G Apc2 APC2, WNT signaling pathway regulator JBrowse link 7 12,258,468 12,280,459 RGD:6907045
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 JBrowse link 16 2,560,103 2,602,035 RGD:6907045
G Axin1 axin 1 RGD:2293188
RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907045
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2298531
RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:6907045
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:2306714
RGD:6907045
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:2306714
RGD:6907045
G Msh3 mutS homolog 3 JBrowse link 2 21,790,048 21,931,791 RGD:6907045
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:2306714
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:2306714
G Pms2 PMS1 homolog 2, mismatch repair system component JBrowse link 12 12,714,394 12,738,654 RGD:2306714
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6907045
G RSA-14-44 RSA-14-44 protein JBrowse link 4 96,831,880 96,833,252 RGD:6907045
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:6907045
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:6907045
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2306282
RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2306282
RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2306282
RGD:6907045
RGD:2308865
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Moleculecisplatin DNA adductsintrastrand and interstrand cisplatin DNA adducts
Gene Grouppotential CRC miRNApotential CRC miRNA

Pathway Gene Annotations

Disease Annotations Associated with Genes in the colorectal cancer pathway
Disease TermsGene Symbols
16p11.2 Deletion SyndromeMapk3
abdominal aortic aneurysmMapk8
abdominal obesity-metabolic syndrome 1Bax , Bcl2
Aberrant Crypt FociApc , Ctnnb1 , Fos , Gsk3b , Mapk1 , Mapk3 , Myc , Tgfb2
Abnormalities, Drug-InducedRhoa
Abortion, SpontaneousTgfb1 , Tgfbr1
acinar cell carcinomaApc
Acro-OsteolysisSmad4
Acromicric DysplasiaSmad2 , Tgfb1
actinic keratosisTgfb1
acute kidney failureBad , Bax , Bcl2 , Gsk3b , Myc , Tgfb1 , Tp53
Acute Liver FailureCasp3 , Casp9 , Mapk8
Acute Lung InjuryBax , Bcl2 , Casp3 , Tgfb1
acute myeloid leukemiaBcl2 , Ccnd1 , Kras , Myc , Tp53
acute myocardial infarctionCasp3 , Gsk3b
Acute Necrotizing PancreatitisBirc5 , Casp3
acute pancreatitisBirc5
acute promyelocytic leukemiaAkt1 , Birc5 , Myc
acute T cell leukemiaBax
adenocarcinomaApc , Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Myc , Pik3ca , Tcf7l2 , Tgfb1 , Tp53
adenoid cystic carcinomaCcnd1 , Kras , Pik3ca , Tp53
adenomaApc , Bcl2 , Ctnnb1 , Kras , Tp53
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
adrenal carcinomaBraf , Ctnnb1 , Pik3ca , Tp53
Adrenal Gland NeoplasmsCtnnb1 , Tp53
Adrenal InsufficiencyBax , Bcl2
adrenocortical carcinomaBraf , Ctnnb1 , Pik3ca , Tp53
adult respiratory distress syndromeApc
adult T-cell leukemiaBirc5 , Tp53
agammaglobulinemiaPik3r1 , Tcf3
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Agammaglobulinemia 8, Autosomal DominantTcf3
Agenesis of Corpus CallosumDcc
Aggressive FibromatosisApc
AIDS-Related Kaposi SarcomaBcl2
alcoholic liver cirrhosisBcl2 , Smad3 , Tgfb1
allergic conjunctivitisTgfb1
allergic contact dermatitisBcl2
allergic hypersensitivity diseaseTgfb1
allergic rhinitisBcl2
Alzheimer's diseaseAkt1 , Apc , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Gsk3b , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3r1 , Tp53
ameloblastomaBraf
amphetamine abuseAkt1 , Fos
amyotrophic lateral sclerosisAkt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Tp53
amyotrophic lateral sclerosis type 1Fos
Anaplastic Thyroid CarcinomaTp53
anemiaKras
Anemia, Refractory, with Excess of BlastsBirc5
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
angiosarcomaCcnd1 , Ctnnb1 , Jun , Kras , Myc , Tp53
Animal Disease ModelsAkt1 , Fos , Kras , Lef1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Rhoa , Tp53
Animal Mammary NeoplasmsApc , Ccnd1 , Pik3r1
anodontiaAxin2
anti-basement membrane glomerulonephritisBax , Bcl2 , Mapk8
anxiety disorderFos
aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
aortic diseaseSmad3 , Smad4
aortic valve insufficiencyTgfb1 , Tgfb2
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
aplastic anemiaTgfb1
arrhythmogenic right ventricular cardiomyopathyTgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arsenic PoisoningTp53
ARTERIAL DISSECTIONSmad3
arteriosclerosisMapk9 , Tgfb1 , Tgfbr2
arteriovenous malformations of the brainKras
ascending colon cancerApc , Msh2
AsphyxiaJun
asthmaBcl2 , Rhoa , Tgfb1
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Kras , Tp53
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Casp3
atopic dermatitisMapk8 , Tgfb1
atrial fibrillationSmad7
AtrophyMapk3
autism spectrum disorderMap2k1 , Mapk3
autistic disorderApc , Bcl2 , Ctnnb1 , Map2k1 , Mapk1 , Mapk3
Autoimmune DiseasesTgfb2
autoimmune hepatitisTgfb1
autoimmune lymphoproliferative syndrome type 4Kras
autoimmune thrombocytopenic purpuraTgfb1
autosomal dominant mental retardation 48Rac1
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal dominant polycystic kidney diseaseFos , Myc
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive limb-girdle muscular dystrophy type 2BApc
autosomal recessive polycystic kidney diseaseAkt1 , Myc , Pik3ca
azoospermiaBcl2
B-Cell Chronic Lymphocytic LeukemiaBcl2 , Braf , Kras , Lef1 , Tp53
B-Cell CLL/Lymphoma 2Bcl2
B-Cell LeukemiaMyc
bacterial infectious diseaseCasp3 , Casp9
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
basal cell carcinomaPik3ca , Tp53
Behcet's diseaseTgfb1
berylliosisTgfb1
bilirubin metabolic disorderBcl2
bipolar disorderAkt1 , Gsk3b
bladder urothelial carcinomaAkt1 , Braf , Ctnnb1 , Kras , Map2k1 , Pik3ca , Tp53
bone development diseaseTgfb2 , Tp53
bone diseaseTgfbr2
Bone FracturesTgfbr2
bone marrow diseaseDcc
Bone Marrow Failure Syndrome 5Tp53
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
brachydactylySmad4
Brain ContusionCasp3
brain diseaseTgfb1
brain gliomaBax , Bcl2 , Casp3
Brain InjuriesAkt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Jun , Rhoa
Brain Injuries, TraumaticBad
brain ischemiaAkt1 , Bad , Bcl2 , Casp3 , Casp9 , Cycs , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Tgfb1 , Tp53
Brain NeoplasmsBraf , Ccnd1 , Ctnnb1 , Pik3ca , Pik3r1 , Pms2 , Tgfbr2 , Tp53
breast adenocarcinomaAkt1 , Kras , Pik3ca , Tp53
breast cancerAkt1 , Apc , Bad , Bax , Braf , Casp3 , Casp9 , Jun , Kras , Map2k1 , Mapk1 , Msh2 , Myc , Pik3ca , Pms2 , Rhoa , Smad4 , Tgfb1 , Tp53
Breast Cancer, FamilialApc , Pik3ca , Pik3r3 , Tp53
breast carcinomaCasp3 , Msh2 , Rhoa , Smad2
Breast NeoplasmsAkt1 , Akt2 , Apc2 , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Lef1 , Myc , Pik3ca , Pik3r1 , Raf1 , Rhoa , Smad4 , Tp53
bronchiolo-alveolar adenocarcinomaCcnd1 , Kras , Tp53
Bronchopulmonary DysplasiaBax , Casp3 , Casp9 , Tp53
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaMyc , Pik3r1 , Pms2 , Tcf3
BurnsBad , Bax , Bcl2 , Casp3 , Ccnd1 , Gsk3b
CachexiaTgfb1
Cafe-au-Lait SpotsPms2
calcinosisCasp3 , Ctnnb1 , Tgfb1
Camurati-Engelmann diseaseTgfb1
cancerBraf , Myc , Pik3ca , Pik3r1 , Tp53
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf , Kras
carcinomaBcl2 , Ccnd1 , Kras , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfbr2 , Tp53
carcinosarcomaTgfb1
cardiac arrestAkt1
Cardiac FibrosisTgfb1
cardiofaciocutaneous syndromeBraf , Kras , Map2k1
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bad , Gsk3b , Mapk1 , Mapk8 , Myc , Rac1 , Raf1 , Rhoa , Tgfb1
cardiomyopathyAkt1 , Kras , Mapk1 , Mapk3 , Tp53
CardiotoxicityRac1 , Tp53
Cardiovascular AbnormalitiesMap2k1
carotid artery diseaseTgfb1 , Tp53
Carotid Artery InjuriesMyc
cataractCasp3 , Casp9 , Map2k1 , Tp53
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCcnd1 , Ctnnb1 , Kras , Tp53
Cell Transformation, NeoplasticApc , Bcl2 , Ccnd1 , Ctnnb1 , Fos , Gsk3b , Jun , Kras , Mapk8 , Myc , Rac1 , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Bcl2 , Casp3 , Casp9
cervical adenocarcinomaTp53
cervical cancerCasp3 , Smad2 , Smad4 , Tp53
cervical squamous cell carcinomaBax , Fos , Tp53
cervix carcinomaTp53
cervix uteri carcinoma in situBcl2 , Ccnd1 , Mlh1 , Msh2
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBad , Bax , Ctnnb1 , Tgfbr1
chemical colitisCasp3
Chemotherapy-Induced Febrile NeutropeniaTp53
childhood pilocytic astrocytomaMapk1
ChloracneCycs
cholangiocarcinomaApc , Cycs , Kras , Smad4 , Tgfb1 , Tgfbr2 , Tp53
cholangitisTgfb2
cholesteatoma of middle earTp53
chorioamnionitisTgfb1
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Chromosome 17 DeletionTp53
Chromosome BreakageMyc
Chronic HepatitisCasp3 , Smad2 , Tgfb1
Chronic Intermittent HypoxiaBax , Bcl2
chronic lymphocytic leukemiaBraf , Kras , Myc , Tp53
chronic myeloid leukemiaAkt1 , Birc5 , Braf , Smad4 , Tgfb1
chronic obstructive pulmonary diseaseCasp3 , Mapk8 , Smad4 , Tgfb1 , Tp53
Chronic PancreatitisBad
Chronic PeriodontitisRac2
CicatrixSmad4
clear cell adenocarcinomaBcl2 , Tp53
clear cell renal cell carcinomaMyc
cleft lipMyc
cleft palateMyc , Tgfb1 , Tgfb2 , Tgfb3
cleft soft palateTgfbr2
CLOVES syndromePik3ca
Cocaine-Related DisordersFos , Mapk1 , Mapk3 , Smad3
cognitive disorderGsk3b , Smad4
Cognitive DysfunctionTp53
colitisMsh2
colon adenocarcinomaApc , Bax , Ctnnb1 , Mapk1 , Mapk3 , Msh6 , Pik3ca , Pik3r3 , Rac1 , Tgfb1
colon adenomaRac1
colon cancerAkt1 , Akt3 , Apc , Bad , Bcl2 , Braf , Casp3 , Ctnnb1 , Gsk3b , Mlh1 , Msh2 , Pik3ca , Pik3r2 , Pik3r5 , Pms2 , Tgfb3 , Tgfbr2 , Tp53
colon carcinomaAkt1 , Apc , Axin2 , Bax , Braf , Ctnnb1 , Dcc , Mlh1 , Msh2 , Pik3ca , Tgfb1 , Tgfb2 , Tp53
Colonic NeoplasmsApc , Axin2 , Bax , Bcl2 , Birc5 , Braf , Casp3 , Ccnd1 , Ctnnb1 , Fos , Gsk3b , Jun , Kras , Lef1 , Mapk8 , Mlh1 , Myc , Pik3r1 , Pik3r2 , Pms2 , Tcf7l2 , Tgfbr2 , Tp53
colorectal adenocarcinomaBraf , Fos , Gsk3b , Jun , Mapk1 , Mapk3 , Mapk8 , Raf1 , Tp53
colorectal adenomaApc , Fos , Jun , Mapk8 , Raf1
colorectal cancerAkt1 , Akt2 , Apc , Axin2 , Braf , Casp9 , Ctnnb1 , Dcc , Mapk9 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pik3cd , Pik3r1 , Rac1 , Rhoa , Smad4 , Smad7 , Tcf3 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
colorectal carcinomaMsh3
Colorectal NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Axin1 , Axin2 , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Dcc , Fos , Kras , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pik3r1 , Pik3r3 , Pms1 , Pms2 , Raf1 , Rhoa , Smad3 , Smad4 , Smad7 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfbr1 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
combined T cell and B cell immunodeficiencyRac2
complex cortical dysplasia with other brain malformationsAkt3 , Pik3ca
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyTgfb2
congenital diaphragmatic herniaRhoa
congenital dyserythropoietic anemiaTp53
congenital heart diseaseTgfb2
congenital hypoplastic anemiaTp53
Congenital Limb DeformitiesTgfb2
congestive heart failureBax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Rac1 , Tp53
connective tissue diseaseSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
contact dermatitisBcl2
Contrast-Induced NephropathyCasp3 , Mapk8
Copper-Overload CirrhosisCasp3 , Smad2 , Tgfb1
coronary artery diseaseAkt1 , Tgfb1
Coronary DiseaseTcf7l2
coronary restenosisMapk1 , Myc , Tp53
coronin-1A deficiencyMapk3
Costello syndromeBraf , Kras , Map2k1
Cowden syndromePik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
Craniofacial AbnormalitiesCtnnb1 , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53
craniopharyngiomaApc , Braf , Ctnnb1
craniosynostosisAxin2
Crohn's diseaseSmad3 , Tcf7
Cronkhite-Canada syndromeSmad4
cryptorchidismCasp3
Currarino TriadPik3ca
cutaneous T cell lymphomaBax , Braf , Rhoa , Tp53
CyanosisTgfb2
cystic fibrosisTgfb1
DeafnessSmad4
degenerative disc diseaseGsk3b , Tgfb1
dementiaBax , Bcl2
demyelinating diseaseMapk1 , Myc , Tp53
dermatomyositisPms1
Developmental DisabilitiesAkt3 , Braf , Mapk3 , Mlh1 , Pik3r2
Diabetes ComplicationsCasp9
diabetes mellitusRac1 , Tcf7l2
Diabetes Mellitus, Experimental Akt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Mapk1 , Mapk3 , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfb2 , Tp53
diabetic angiopathyCasp3
Diabetic CardiomyopathiesBad , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Mapk1 , Mapk3
Diabetic CystopathyBad
diabetic encephalopathyGsk3b
Diabetic NephropathiesCasp3 , Casp9 , Gsk3b , Mapk1 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53
diabetic neuropathyBad , Casp3 , Tgfb1 , Tgfb2 , Tgfb3
diabetic retinopathyCasp3 , Casp9
Diamond-Blackfan anemiaTp53
Diamond-Blackfan Anemia 6Tp53
Diaphragmatic HerniaTgfb1
diffuse large B-cell lymphomaBcl2 , Pik3ca , Pik3cb , Pik3cd , Tp53
DiGeorge syndromeTgfbr2
Digestive System NeoplasmsApc , Msh3
Dilatation, PathologicTgfb1
dilated cardiomyopathyBax , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Kras , Lef1 , Rac1 , Raf1 , Tp53
dilated cardiomyopathy 1NNRaf1
diseaseCtnnb1
disease of cellular proliferationApc , Braf , Ctnnb1 , Kras , Map2k1 , Myc , Pik3ca , Pik3r1 , Tp53
Disease ProgressionBcl2 , Ctnnb1 , Myc , Pik3ca
Dissecting AneurysmSmad3 , Tgfbr1 , Tgfbr2
Drug-Induced DyskinesiaGsk3b
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
ductal carcinoma in situBcl2 , Birc5 , Ccnd1 , Tp53
duodenal ulcerTgfb1
duodenum adenocarcinomaApc
DwarfismTp53
dysembryoplastic neuroepithelial tumorBraf
dyskeratosis congenitaTp53
EdemaCasp3 , Casp9
Ehlers-Danlos syndromeTgfb1
EmphysemaTp53
end stage renal failureBcl2 , Tgfb1
endodermal sinus tumorCtnnb1
endometrial adenocarcinomaAxin2 , Jun , Kras , Mapk1 , Mapk3 , Pik3r1 , Tp53
endometrial cancerAkt2 , Apc , Bad , Kras , Msh3 , Msh6 , Pik3cb , Pik3cd , Pik3r1 , Smad2 , Smad3 , Smad7 , Tp53
endometrial carcinomaApc , Braf , Gsk3b , Jun , Kras , Mapk1 , Mapk3 , Mlh1 , Msh3 , Msh6 , Pik3ca , Pik3r1 , Smad4 , Tp53
endometrial hyperplasiaBirc5 , Kras
Endometrial NeoplasmsApc , Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Mapk3 , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Pik3cb , Tp53
Endometrioid CarcinomasAkt1 , Apc , Birc5 , Ctnnb1 , Kras , Mapk1 , Mapk3 , Pik3r2
endometriosisBax , Bcl2 , Birc5 , Fos , Kras , Tgfb2
endometritisCasp3 , Casp9
endomyocardial fibrosisTgfb1
EndotoxemiaBax , Bcl2 , Casp3 , Casp9
eosinophilic esophagitisTgfb1
epidermal nevusKras , Pik3ca
epilepsyAkt1 , Fos , Tgfb1
esophageal cancerDcc , Tgfbr2 , Tp53
esophageal carcinomaCtnnb1 , Dcc , Kras , Myc , Pik3ca , Rhoa , Smad4 , Tp53
Esophageal NeoplasmsBax , Bcl2 , Ccnd1 , Dcc , Myc , Tgfbr2 , Tp53
esophagus adenocarcinomaPik3ca , Smad4 , Tp53
esophagus squamous cell carcinomaCtnnb1 , Dcc
essential thrombocythemiaTgfb1
Experimental Allergic AsthmaBcl2
Experimental ArthritisAkt1 , Bax , Bcl2 , Gsk3b , Pik3cd , Tgfbr2
Experimental Autoimmune EncephalomyelitisCasp3 , Casp9 , Rhoa , Tgfb1 , Tgfb2
Experimental Autoimmune MyocarditisCasp3 , Casp9
Experimental Autoimmune NeuritisDcc , Rhoa
Experimental ColitisMapk1 , Mapk3 , Smad4
Experimental Liver CirrhosisAppl1 , Bcl2 , Birc5 , Fos , Mapk1 , Mapk3 , Myc , Rac2 , Rhoa , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2
Experimental Liver NeoplasmsBcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Tgfb1 , Tp53
Experimental NeoplasmsBraf , Ccnd1 , Kras , Tp53
Experimental SarcomaKras
extrahepatic cholestasisFos , Jun , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tgfb1
Exudative Vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Eye AbnormalitiesApc , Tgfb2 , Tgfbr2
Facial AsymmetryPik3ca
factor VIII deficiencyTgfb1
familial adenomatous polyposisAkt1 , Apc , Msh3
familial adenomatous polyposis 1Apc
familial adenomatous polyposis 4Msh3
familial hyperlipidemiaApc , Tgfb1
familial hypertrophic cardiomyopathyKras , Raf1
familial partial lipodystrophyAkt2
Familial Prostate CancerBcl2 , Map2k1 , Tcf7l2
Familial Thoracic Aortic Aneurysm 1Smad3 , Tgfbr2
Familial Thoracic Aortic Aneurysm 3Tgfbr2
FatigueTgfbr2
fatty liver diseaseCycs , Mapk8 , Myc
Female InfertilityMapk1 , Mapk3 , Tp53
Femoral FracturesLef1
Ferguson-Smith tumorTgfbr1
Fetal Growth RetardationBax , Bcl2 , Casp3
fibrillary astrocytomaKras
Fibromatosis, AbdominalApc
FibrosisAkt1 , Rhoa , Tgfb1
Fibrous Dysplasia of BoneFos
focal segmental glomerulosclerosisCasp9 , Tgfb1
follicular lymphomaBcl2
Follicular Thyroid CancerBraf
follicular thyroid carcinomaBraf , Kras
Funnel ChestTp53
gallbladder carcinomaPik3ca , Tp53
Gallbladder NeoplasmsApc , Bcl2 , Kras , Tgfb1 , Tp53
gangliogliomaBraf
Gardner SyndromeApc
gastric adenocarcinomaAkt1 , Braf , Ctnnb1 , Kras , Map2k1 , Mlh1 , Pik3ca , Raf1 , Rhoa , Smad4 , Tp53
Gastric PolyposisApc
gastric ulcerBad , Bcl2 , Casp3 , Mapk1 , Mapk3
Gastrointestinal HemorrhageApc , Bax
Gastrointestinal NeoplasmsApc , Pik3ca
gastrointestinal stromal tumorApc , Braf , Kras , Tgfbr2
gastrointestinal system cancerSmad4
Gaucher's diseaseMsh6 , Tp53
Gaucher's disease type IMsh6 , Tp53
Gaze Palsy, Familial Horizontal, with Progressive ScoliosisDcc
Gaze Palsy, Familial Horizontal, with Progressive Scoliosis, 2Dcc
Generalized EpilepsyMapk10
genetic diseaseAkt2 , Akt3 , Axin2 , Braf , Ctnnb1 , Kras , Map2k1 , Mapk1 , Msh6 , Pik3ca , Pik3r1 , Pik3r2 , Raf1 , Rhoa , Smad2 , Smad4 , Tgfb2 , Tgfbr2
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsBirc5 , Mlh1 , Msh2 , Rhoa
germinomaBraf
gestational diabetesTcf7l2
glaucomaBad , Bax , Bcl2 , Tgfb2
glioblastoma multiformeAkt1 , Akt3 , Apc , Braf , Kras , Msh2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Tp53
GliosisMapk1 , Mapk3
glomerulonephritisFos , Mapk1
grade III astrocytomaKras , Tp53
Graft vs Host DiseaseTp53
granulosa cell tumorCtnnb1
Graves' diseaseTp53
Growth DisordersPik3ca
Growth Mental Deficiency Syndrome of MyhreSmad4
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsBcl2 , Mapk1 , Mapk3 , Pik3ca , Tp53
head and neck squamous cell carcinomaAkt1 , Braf , Ccnd1 , Ctnnb1 , Map2k1 , Mapk1 , Pik3ca , Rac1 , Rhoa , Smad4 , Tp53
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseBax , Casp3 , Casp9 , Gsk3b , Rac2 , Tgfb1
heart valve diseaseCasp3
Heat StrokeFos , Jun
HematuriaFos
HemimegalencephalyPik3ca
hemolytic-uremic syndromeFos
HemorrhageFos
Hepatic InsufficiencyTgfb1
hepatoblastomaApc , Ctnnb1 , Tp53
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
hepatocellular adenomaCtnnb1 , Kras
hepatocellular carcinomaAkt1 , Akt2 , Apc , Axin1 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Myc , Pik3ca , Rac1 , Smad2 , Smad4 , Tgfb1 , Tgfbr2 , Tp53
HepatomegalyTgfb1
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeMlh1 , Pms1 , Tp53
Hereditary Desmoid DiseaseApc , Ctnnb1
hereditary hemorrhagic telangiectasiaSmad4
Hereditary Hemorrhagic Telangiectasia, Type 1Smad4 , Tgfb1
Hereditary Neoplastic SyndromesApc , Axin2 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Smad4 , Tcf7 , Tp53
hereditary nonpolyposis colorectal cancer type 2Mlh1
hereditary nonpolyposis colorectal cancer type 4Pms2
hereditary nonpolyposis colorectal cancer type 5Msh6
hereditary nonpolyposis colorectal cancer type 6Tgfbr2
Hereditary PancreatitisCasp9
hereditary spastic paraplegia 11Tp53
Hirschsprung Disease 1Tgfb2
Hirschsprung's diseaseAxin2 , Tgfb2
Hodgkin's lymphomaJun
Holt-Oram syndromeTgfb2
human immunodeficiency virus infectious diseaseBax
Huntington's diseaseBax , Bcl2 , Casp3 , Casp9 , Cycs , Msh2
Hydatidiform MoleMlh1 , Msh2
Hydatidiform Mole, InvasiveMsh2
HyperalgesiaFos , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1
HypercholesterolemiaCasp3 , Casp9
HyperkinesisFos
HyperoxiaTgfb1
HyperparathyroidismCcnd1 , Myc
HyperplasiaAkt1 , Apc , Bax , Ccnd1 , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2
hypertensionAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Fos , Gsk3b , Jun , Kras , Mapk8 , Pik3r1 , Rhoa , Tgfb1 , Tgfb3 , Tp53
hypertrophic cardiomyopathyBcl2 , Casp3 , Ctnnb1 , Myc , Raf1 , Tgfb1 , Tgfb3 , Tp53
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
hypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypothermiaBcl2
hypothyroidismBad
HypoxiaCasp3
Hypoxia-Ischemia, BrainBax , Bcl2 , Casp3 , Casp9
IgA glomerulonephritisTgfb1
Immunoblastic LymphadenopathyRhoa
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
imperforate anusCtnnb1
impotenceAkt1 , Bad , Bax , Bcl2 , Casp3 , Ccnd1 , Tgfb1
in situ carcinomaAkt1 , Ctnnb1
Infant, Newborn, DiseasesTgfb1
InflammationAkt1 , Tgfb1
inflammatory bowel diseaseApc , Apc2 , Tgfb1
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHYTgfb1
inguinal herniaTgfbr2
Insulin ResistanceAkt2 , Bad , Casp3 , Mapk3 , Pik3r1 , Tcf7l2
insulinomaTgfb1
intellectual disabilityApc , Ctnnb1 , Dcc , Fos , Kras , Ralgds , Tgfb3
intermediate coronary syndromeAkt1
intermittent claudicationBad , Bax , Casp3
interstitial lung diseaseTgfb1
Intervertebral Disc DisplacementAkt1
intestinal diseaseBax , Bcl2 , Casp3
Intestinal NeoplasmsApc , Bax , Bcl2 , Ctnnb1 , Gsk3b , Mapk8
Intestinal PolypsApc , Ccnd1 , Jun
Intestinal Reperfusion InjuryCasp3 , Casp9
intracranial aneurysmBcl2
intrahepatic cholangiocarcinomaApc , Kras
invasive ductal carcinomaAkt1 , Smad4
invasive lobular carcinomaCcnd1 , Ctnnb1
ischemiaAkt2 , Bax , Cycs , Mapk9 , Raf1 , Tp53
juvenile myelomonocytic leukemiaKras , Rac2
juvenile polyposis syndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
juvenile rheumatoid arthritisFos , Jun , Kras , Mapk1 , Smad3 , Tcf7l2
Kaposi's sarcomaTp53
Kashin-Beck DiseaseBax , Bcl2
keratosisTp53
kidney diseaseCasp3 , Casp9 , Mapk1 , Tgfb1 , Tgfbr1 , Tgfbr2
Kidney NeoplasmsAkt1 , Birc5 , Braf , Ccnd1 , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryBax , Bcl2 , Casp3 , Fos , Myc
Klatskin's tumorApc
Knee OsteoarthritisBax , Bcl2 , Ctnnb1
Kuhnt-Junius degenerationMapk8
Langerhans-cell histiocytosisBraf
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
learning disabilityBcl2
Leber hereditary optic neuropathyTp53
Left Ventricular HypertrophyMyc , Rac1 , Rhoa
left ventricular noncompactionTgfb3
leiomyomaBax , Bcl2 , Myc , Smad3 , Tgfbr1
Lennox-Gastaut syndromeMapk10
LEOPARD syndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaBad , Ccnd1 , Tp53
LeukocytosisApc , Kras
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 1Tp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lip NeoplasmsTp53
Lipoyltransferase 1 DeficiencyTgfbr2 , Tp53
liver benign neoplasmApc , Braf , Ccnd1 , Ctnnb1 , Jun , Kras , Myc , Raf1 , Tp53
liver cancerAkt1 , Apc , Axin1 , Ctnnb1 , Kras , Pik3ca , Tp53
liver cirrhosisCasp3 , Casp9 , Ctnnb1 , Smad3 , Tgfb1 , Tgfbr1
liver diseaseRac1
Liver InjuryMyc
Liver Reperfusion InjuryBad , Bax , Bcl2 , Casp9 , Gsk3b , Mapk8
localized sclerodermaTgfb1
Loeys-Dietz syndromeSmad3 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 1Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 2Tgfbr2
Loeys-Dietz syndrome 3Smad3
Loeys-Dietz syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
low tension glaucomaTp53
lung adenocarcinomaAkt1 , Apc , Braf , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mlh1 , Myc , Pik3ca , Pik3r1 , Raf1 , Rhoa , Smad4 , Tp53
lung cancerBraf , Kras , Pik3ca
lung carcinomaCtnnb1 , Mlh1
lung diseaseTgfb1
Lung NeoplasmsAkt1 , Apc , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Raf1 , Tgfb1 , Tgfbr2 , Tp53
Lung Reperfusion InjuryBax , Bcl2 , Casp3 , Myc
lung small cell carcinomaAkt1 , Bcl2 , Ccnd1 , Myc , Pik3ca , Pik3r1 , Tp53
lung squamous cell carcinomaAkt1 , Braf , Ccnd1 , Ctnnb1 , Cycs , Kras , Pik3ca , Tp53
LymphangiectasisRaf1
Lymphatic MetastasisBcl2 , Birc5 , Casp9 , Ctnnb1 , Cycs , Pik3ca , Pik3cb , Rhoa , Smad4 , Tp53
lymphomaKras , Mlh1 , Rac2 , Tp53
lymphopeniaRac2
Lynch syndromeApc , Mlh1 , Msh2 , Msh6 , Pms1 , Pms2 , Smad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
Lynch syndrome 1Msh2 , Msh6 , Pms1
MacrocephalyAkt3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macrocytic anemiaApc
macular degenerationBad , Bax
Macular Dystrophy, Concentric AnnularMsh6
male infertilityBax , Bcl2 , Tp53
malignant gliomaAkt2 , Bad , Birc5 , Braf , Ccnd1 , Kras , Map2k1 , Mapk3 , Pik3ca , Pik3r3 , Raf1 , Tp53
malignant mesotheliomaBcl2 , Ctnnb1 , Raf1 , Tgfb2 , Tp53
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Mapk1 , Mapk3 , Myc , Pik3r1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
Mandibular NeoplasmsBraf , Ctnnb1
mantle cell lymphomaCcnd1 , Ctnnb1 , Gsk3b , Pik3cd
Marfan syndromeTgfbr2
marginal zone B-cell lymphomaTp53
maturity-onset diabetes of the young type 14Appl1
medulloblastomaApc , Ccnd1 , Ctnnb1 , Myc , Pik3ca , Tp53
Megakaryoblastic Leukemia of Down SyndromeTp53
megakaryocytic leukemiaBirc5 , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Apc , Bcl2 , Braf , Ctnnb1 , Dcc , Kras , Map2k1 , Myc , Pik3ca , Pik3r1 , Rac1 , Rac2 , Raf1 , Tp53
membranoproliferative glomerulonephritisTgfbr2
membranous glomerulonephritisRhoa
Memory DisordersBcl2
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionBax , Gsk3b , Jun
Mercury Poisoning, Nervous SystemJun
Merkel cell carcinomaMyc
mesenchymal chondrosarcomaBcl2
MesotheliomaApc , Tp53
Metabolic SyndromeTgfb1
MetaplasiaAxin2 , Bcl2
methylmalonic acidemiaCycs
methylmalonic aciduria and homocystinuria type cblCMsh6
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityBax , Braf , Msh3 , Msh6 , Tgfbr2
middle cerebral artery infarctionBad , Bax , Bcl2 , Casp3 , Casp9 , Fos , Gsk3b , Mapk1 , Mapk3
migraineTgfbr2
Mirror Movements 1Dcc
Mitochondrial Complex I Deficiency, Nuclear Type 20Pik3ca
Miyoshi muscular dystrophyApc
Miyoshi muscular dystrophy 1Apc
Monoclonal B-Cell LymphocytosisApc
morphine dependenceBax , Bcl2
Mouth NeoplasmsKras , Pik3ca , Tp53
Muir-Torre syndromeMlh1 , Msh2
Multi-Infarct DementiaBax , Bcl2
Multiple AbnormalitiesCtnnb1 , Gsk3b , Kras , Mapk1 , Pik3r2 , Smad2
Multiple Hamartoma SyndromePik3ca
multiple myelomaBcl2 , Braf , Ccnd1 , Kras , Pik3ca , Tgfb1 , Tp53
Multiple Organ FailureMapk1
Multiple Primary NeoplasmsMlh1
multiple sclerosisRhoa
muscular atrophyAkt1 , Ctnnb1 , Gsk3b
muscular diseaseSmad4 , Tgfb1
Musculoskeletal AbnormalitiesTgfb2
Mycoplasma InfectionsCasp3
myelodysplastic syndromeKras , Myc , Tp53
myelofibrosisTgfb1 , Tp53
myeloid neoplasmKras
myeloid sarcomaKras
myocardial infarctionAkt1 , Bax , Bcl2 , Birc5 , Casp3 , Gsk3b , Mapk1 , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53
Myocardial IschemiaBax , Bcl2 , Ccnd1
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Rhoa , Smad3 , Smad4 , Tgfb1 , Tp53
Myopathy, Distal, with Anterior Tibial OnsetApc
nasal cavity cancerTp53
Nasal PolypsJun , Tgfb1
Nasopharyngeal NeoplasmsCcnd1 , Pik3ca , Tp53
nasopharynx carcinomaBcl2 , Tp53
NecrosisBcl2
Nematode InfectionsPik3r1
Neoplasm InvasivenessCtnnb1 , Lef1 , Mapk1 , Mapk3 , Rhoa , Tgfb1
Neoplasm MetastasisAkt2 , Bax , Bcl2 , Braf , Casp3 , Ccnd1 , Ctnnb1 , Kras , Lef1 , Mapk1 , Mapk3 , Mapk9 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r3 , Pms2 , Rac1 , Rhoa , Tcf3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
Neoplasm MicrometastasisCycs
nephritisSmad7
nephroblastomaCtnnb1 , Myc , Tp53
nephrolithiasisTgfb1
nephrotic syndromeTgfb1
Nerve DegenerationBax , Bcl2 , Casp3 , Ctnnb1 , Mapk1 , Mapk3
Nerve Sheath NeoplasmsTp53
nervous system diseaseCasp3 , Casp9 , Fos , Tp53
NeuralgiaTgfb1
neuroblastomaKras , Myc , Pik3ca , Tp53
Neurodevelopmental DisordersCtnnb1 , Tcf7l2
neuroectodermal tumorMyc
neuroendocrine tumorBraf
neuronal ceroid lipofuscinosis 6Gsk3b , Mapk1 , Mapk3
neuronal ceroid lipofuscinosis 8Tgfbr2
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf
No-Reflow PhenomenonCtnnb1
non-Hodgkin lymphomaBcl2 , Braf , Ccnd1 , Map2k1 , Myc , Pik3ca , Rhoa , Tp53
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Apc , Bad , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Cycs , Kras , Map2k1 , Myc , Pik3ca , Raf1 , Tp53
nonalcoholic fatty liver diseaseMapk8 , Tgfb1
Nonseminomatous Germ Cell TumorBraf
nonsyndromic deafnessTgfb3
Noonan syndromeBraf , Kras , Map2k1 , Raf1
Noonan syndrome 1Braf , Map2k1 , Raf1
Noonan syndrome 3Kras , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 7Braf
NSAID-EnteropathyCasp9
obesityAkt1 , Akt2 , Bad , Bcl2 , Cycs , Mapk1 , Mapk3 , Myc , Pik3r1 , Rhoa , Tgfb1
Occupational AsthmaTgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
Odontogenic MyxomaTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
oligomeganephroniaBcl2
Optic Nerve InjuriesBax , Bcl2 , Jun , Rhoa
Oral Lichen PlanusTp53
oral mucosa leukoplakiaBcl2 , Tp53
oral submucous fibrosisTgfb1 , Tp53
Oropharyngeal NeoplasmsTp53
Ossification, HeterotopicSmad4
osteoarthritisBad , Bax , Bcl2 , Casp3 , Casp9 , Smad3 , Tgfb1
Osteoarthritis, ExperimentalCasp3 , Mapk3
Osteoarthritis, HipSmad3
osteochondrodysplasiaBcl2 , Tgfb1 , Tgfb2 , Tgfbr1
osteogenesis imperfectaSmad4
osteopetrosisJun
osteoporosisBax , Bcl2 , Myc , Tgfb1
osteosarcomaAkt1 , Jun , Myc , Tp53
ovarian cancerAkt1 , Apc , Ctnnb1 , Kras , Lef1 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Smad2 , Smad4 , Tp53
ovarian carcinomaAkt2 , Ccnd1 , Map2k1 , Rhoa , Smad2
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2 , Birc5 , Braf , Ctnnb1 , Gsk3b , Kras , Mapk1 , Mapk3 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r1 , Smad7 , Tp53
ovarian serous cystadenocarcinomaBraf , Pik3ca , Tp53
ovarian small cell carcinomaTp53
ovary epithelial cancerPik3ca
ovary serous adenocarcinomaTp53
Oxygen-Induced RetinopathyMapk8
PainAkt1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaAkt3 , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk9 , Pik3ca , Rac1 , Raf1 , Smad4 , Tp53
pancreatic cancerAkt1 , Akt2 , Apc , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Cycs , Kras , Myc , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53
pancreatic carcinomaKras , Myc , Raf1 , Smad4 , Tp53
pancreatic ductal adenocarcinomaCcnd1 , Mapk8 , Pik3r2 , Rac1
pancreatic ductal carcinomaCcnd1 , Kras , Mapk3 , Pms1 , Tgfb1 , Tgfbr2
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisCasp3 , Map2k1
Pancreatitis, Experimental, Acute Kras
pancytopeniaTp53
papillary renal cell carcinomaBraf , Ctnnb1 , Msh2 , Pik3ca , Tp53
papillary thyroid carcinomaBraf , Ccnd1 , Ctnnb1 , Lef1 , Myc
papillomaCcnd1 , Tgfb1
paranasal sinus neoplasmTp53
paraplegiaAkt1
Paraquat LungSmad7 , Tgfb1
Parasitic Liver DiseasesKras , Smad4 , Tp53
Parathyroid NeoplasmsCtnnb1
Parkinson's diseaseAkt1 , Casp3 , Casp9 , Gsk3b
Parkinsonian DisordersBad , Casp3 , Casp9
Pediatric Adrenocortical CarcinomaTp53
penile neoplasmCcnd1 , Kras , Pik3ca , Tp53
periampullary adenomaApc
peripheral nervous system diseaseCasp9 , Jun
peripheral T-cell lymphomaRhoa
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsCtnnb1
peritonitisGsk3b
Peyronie's diseaseTgfb1
Phyllodes TumorCtnnb1 , Tp53
Pick's diseaseFos
pilocytic astrocytomaKras
pilomatrixomaCtnnb1
pituitary carcinomaPms2
plasmacytomaBcl2 , Braf , Kras , Pik3ca , Tp53
pleomorphic xanthoastrocytomaBraf , Cycs , Tp53
pleural diseaseTgfb1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaTgfb1
PoisoningGsk3b
polycystic kidney diseaseMyc
Polycystic Kidney Disease, Type 1Myc
polycystic ovary syndromeAkt2 , Bax , Bcl2
PolymicrogyriaAkt3
PolymyositisPms1
PolyploidyTp53
portal hypertensionPik3r1
post-traumatic stress disorderBax , Bcl2 , Casp9
Posterior Leukoencephalopathy SyndromeTgfb1
Postmenopausal OsteoporosisTgfb1
pre-malignant neoplasmAkt1 , Bax , Casp3 , Casp9 , Ccnd1 , Mapk8 , Mapk9 , Smad3 , Smad4 , Tp53
precursor B lymphoblastic lymphoma/leukemiaCcnd1 , Tcf3 , Tp53
precursor lymphoblastic lymphoma/leukemiaBax , Bcl2 , Ccnd1 , Kras , Myc , Pms2 , Tcf3 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaBax , Bcl2 , Kras
Premature AgingBax , Bcl2 , Tp53
priapismBcl2
primary biliary cirrhosisTgfb1
primary open angle glaucomaTp53
primary pulmonary hypertensionSmad4
Primitive Neuroectodermal TumorsPms2
prion diseaseBax
Progressive Osseous HeteroplasiaCtnnb1
prolactinomaMyc
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Ctnnb1 , Jun , Map2k1 , Mapk1 , Myc , Pik3ca , Pik3cb , Raf1 , Smad4 , Tp53
prostate cancerAkt1 , Akt2 , Akt3 , Apc , Bax , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Kras , Lef1 , Mapk10 , Msh2 , Myc , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pms2 , Rac2 , Raf1 , Smad3 , Tcf3 , Tcf7 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53
prostate carcinomaAkt2 , Bad , Bax , Jun , Tp53
prostate carcinoma in situCcnd1 , Kras , Lef1 , Myc , Smad4
prostatic hypertrophyBad , Myc
Prostatic NeoplasmsAkt1 , Apc , Bad , Bax , Bcl2 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Jun , Kras , Mapk3 , Mlh1 , Msh3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pms1 , Smad4 , Tgfb1 , Tgfbr2 , Tp53
prostatitisSmad4
proteinuriaRhoa , Tgfb1
Proteus syndromeAkt1
psoriasisTgfb1 , Tp53
PTEN hamartoma tumor syndromePik3ca
pterygiumTp53
pulmonary emphysemaJun , Tgfb1
pulmonary fibrosisBad , Smad4 , Smad7 , Tgfb1 , Tgfbr2
pulmonary hypertensionBcl2 , Birc5 , Mapk1 , Mapk3 , Myc , Pms2 , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53
pulmonary sarcoidosisTgfb1
pulmonary tuberculosisJun
pulmonary valve stenosisBraf
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalCasp3 , Casp9 , Mapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Kras , Map2k1 , Raf1
rectal neoplasmApc , Fos , Mapk8 , Pik3ca , Pik3cb
rectum adenocarcinomaApc
RecurrenceKras
Refractory AnemiaBirc5
renal carcinomaJun , Pik3ca , Tp53
renal cell carcinomaAkt1 , Akt3 , Apc , Bad , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Jun , Kras , Map2k1 , Mapk1 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r1 , Smad2 , Smad4 , Tgfb1 , Tp53
renal fibrosisKras , Mapk1 , Myc
Reperfusion InjuryAkt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ccnd1 , Dcc , Fos , Jun , Mapk8 , Mapk9 , Pik3r1 , Tgfbr2 , Tp53
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryBad , Bax , Bcl2
retinal degenerationBax , Bcl2
retinal detachmentCasp3 , Casp9
retinal diseaseCasp3
rhabdoid cancerMyc
rhabdomyosarcomaPms2 , Tp53
rhinitisTgfb1
Right Ventricular HypertrophyAkt1 , Tgfb1
salivary gland diseaseCasp3
Salivary Gland NeoplasmsCcnd1
SAPHO syndromeTp53
sarcoidosisTgfb1
sarcomaPik3ca , Tp53
SarcopeniaBax , Bcl2
schizophreniaAkt1 , Gsk3b , Mapk3 , Mapk8 , Pik3cb , Tp53
sciatic neuropathyCasp3 , Gsk3b
scimitar syndromeSmad2
scrapieBax , Casp3 , Casp9
sebaceous gland neoplasmLef1
Sebaceous Nevus of JadassohnKras
Sebaceous Nevus Syndrome and HemimegalencephalyKras
seborrheic keratosisPik3ca
seminomaKras , Smad4
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
Sensenbrenner syndromeTgfb3
SepsisBad , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Tgfb1
Septic PeritonitisPik3r1
serous cystadenocarcinomaTp53
Serrated PolyposisApc
severe combined immunodeficiencyRac2
Sezary's diseaseBraf , Mapk1 , Tp53
ShockMapk1 , Mapk3
Shock, HemorrhagicBad , Bcl2 , Casp3 , Mapk1 , Myc
SHORT SyndromePik3r1
sickle cell anemiaTgfb1
sigmoid colon cancerApc , Msh2 , Msh6
silicosisJun
Sjogren's syndromeTgfb1
skin melanomaAkt1 , Braf , Ctnnb1 , Map2k1 , Pik3ca , Rac1 , Raf1
Skin NeoplasmsAkt1 , Ctnnb1 , Tgfb1 , Tgfbr1 , Tp53
small cell carcinomaBirc5 , Tp53
small intestine adenocarcinomaMap2k1
Small-For-Size SyndromeBad
Soft Tissue NeoplasmsBcl2
SOTOS SYNDROME 3Apc2
spermatic cord torsionCasp3
Spinal Cord InjuriesAkt1 , Bax , Bcl2 , Casp3 , Casp9 , Dcc , Jun , Tgfb1 , Tgfb2 , Tp53
Spinal Cord Reperfusion InjuryBad
SplenomegalyApc , Kras
Spondylocostal Dysostosis 5Mapk3
sporadic breast cancerMlh1
Sporadic Papillary Renal Cell CarcinomaBraf , Myc , Pik3ca , Tp53
squamous cell carcinomaAkt1 , Bcl2 , Birc5 , Ccnd1 , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Tgfb1 , Tp53
status epilepticusBax , Bcl2 , Casp3 , Ccnd1 , Fos , Gsk3b , Jun
Stevens-Johnson syndromeCtnnb1
stomach cancerApc , Ctnnb1 , Kras , Pik3ca , Tp53
stomach carcinomaBirc5 , Kras
Stomach NeoplasmsApc , Birc5 , Ccnd1 , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Pik3ca , Rhoa , Smad4 , Tp53
StrokeAkt1 , Casp3 , Ctnnb1 , Mapk8 , Pik3ca , Tgfb1
Subarachnoid HemorrhageBcl2 , Casp3 , Casp9 , Gsk3b
substance-induced psychosisAkt1
substance-related disorderGsk3b
Supratentorial NeoplasmsPms2
synovial sarcomaBcl2
systemic lupus erythematosusTcf7
systemic sclerodermaTgfbr1
T-Cell LymphomaAkt1 , Rhoa , Tp53
TachycardiaGsk3b
tauopathyGsk3b
Tendon InjuriesFos
teratomaBax , Ctnnb1
Testis Reperfusion InjuryBax , Bcl2 , Casp3 , Casp9 , Mapk1 , Mapk3
thoracic aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
thrombocytopeniaCycs , Tgfb1
Thrombocytopenia 4Cycs
thrombosisPik3cb
thymomaTp53
Thymus NeoplasmsTp53
thyroid cancerMapk1 , Myc
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Kras , Pik3ca , Tp53
thyroiditisBax
Tongue NeoplasmsBcl2 , Fos , Tp53
tongue squamous cell carcinomaTp53
tooth agenesisAxin2
toxic encephalopathyCasp3 , Fos
toxoplasmosisBax
tracheal stenosisTgfb1
transient cerebral ischemiaBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
transitional cell carcinomaAkt1 , Apc , Bcl2 , Birc5 , Braf , Casp3 , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Pik3ca , Smad4 , Tp53
Transplant RejectionMyc
trichorhinophalangeal syndrome type IMyc
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaFos , Mapk1 , Mapk3 , Mapk8 , Mapk9
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeApc , Mlh1 , Msh2 , Msh6 , Pms2 , Smad4 , Tp53
Turcot SyndromeApc , Mlh1 , Msh2 , Msh6 , Pms2
type 1 diabetes mellitusCasp3 , Casp9 , Tgfb1
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Bax , Bcl2 , Braf , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3cb , Pik3r1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr2
ulcerative colitisCasp3
uremiaTgfb1 , Tgfbr1
ureteral obstructionAkt1 , Casp3 , Casp9 , Mapk1 , Mapk3 , Smad3 , Tgfb1 , Tgfb2
urethral obstructionMapk1 , Tgfb1
urinary bladder cancerAkt1 , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Kras , Mlh1 , Msh2 , Myc , Pms2 , Rhoa , Smad2 , Smad4 , Tgfbr1 , Tp53
Urinary Bladder NeoplasmKras
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urogenital NeoplasmsMsh2 , Tp53
Urologic NeoplasmsBirc5 , Ccnd1 , Rhoa , Tp53
urticariaTgfb1
Usher syndromeTgfb2
uterine carcinosarcomaPik3ca , Pik3r1 , Tp53
Uterine Cervical NeoplasmsAkt1 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Mapk1 , Mlh1 , Msh2 , Myc , Pik3ca , Smad4 , Tp53
Uterine NeoplasmsBraf , Ctnnb1 , Kras , Map2k1 , Pik3ca , Pik3r1 , Rac1 , Smad3 , Tp53
uveitisTgfb1
varicoceleCasp9
Vascular CalcificationCtnnb1
vascular dementiaGsk3b , Tp53
Vascular MalformationsPik3ca
vasculogenic impotenceTgfbr2
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftRac1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
ventricular septal defectBraf , Fos , Tgfb3
Ventricular TachycardiaRaf1
Viral MyocarditisCasp3
visual epilepsyBad , Ccnd1 , Fos , Msh2 , Pik3ca
vitiligoPik3r1 , Tgfb1
von Hippel-Lindau diseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsMlh1 , Msh2 , Tp53
Wallerian DegenerationTgfb1 , Tgfb2
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
withdrawal disorderFos , Mapk1 , Mapk3
Wolff-Parkinson-White syndromeTgfbr2
Wounds and InjuriesTgfb1 , Tgfb2 , Tgfb3
xeroderma pigmentosumTp53
Pathway Annotations Associated with Genes in the colorectal cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Jun , Mapk1 , Mapk8 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered mismatch repair pathwayMlh1 , Msh2 , Msh6 , Pms1 , Pms2
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer's disease pathwayBad , Casp3 , Casp9 , Cycs , Cyct , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1 , Smad4 , Smad7
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9 , Rac1
calcium signaling pathway via the calcium-sensing receptorRhoa
cardiolipin metabolic pathwayCycs
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Braf , Casp9 , Ccnd1 , Cycs , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rhoa , RSA-14-44
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Appl1 , Axin1 , Axin2 , Bad , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Cycs , Cyct , Dcc , Fos , Gsk3b , Jun , Kras , Lef1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pms1 , Pms2 , Rac1 , Rac2 , Raf1 , Ralgds , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Smad7 , Tcf3 , Tcf7 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Ctnnb1 , Pik3ca , Pik3r1 , Rac1 , Rhoa
eicosanoid signaling pathwayAkt1 , Pik3r5 , Rac1 , Rhoa
electron transport chain pathwayCycs
endocytosis pathwayRhoa , RSA-14-44 , Smad2 , Smad3 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayBax , Bcl2 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Fos , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1 , Rhoa
Entamoebiasis pathwayCasp3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1 , Rhoa
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
erythropoietin signaling pathwayBcl2 , Mapk8 , Pik3r1
extrinsic apoptotic pathwayCasp3
FasL mediated signaling pathwayAkt1 , Casp3 , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3r1
forkhead class A signaling pathwayAkt1 , Fos , Jun
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayMapk8 , Mapk9 , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayJun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
histone modification pathwayBirc5
Huntington's disease pathwayBax , Casp3 , Casp9 , Cycs , Cyct , Tp53
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Fos , Jun , Smad3 , Smad4
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Cycs , Cyct , Gsk3b , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Rac1
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
interleukin-1 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
interleukin-12 signaling pathwayFos
interleukin-2 signaling pathwayBcl2 , Fos , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3r1 , Raf1 , Rhoa
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Fos , Jun , Myc , Pik3ca , Pik3r1 , Rac1
intrinsic apoptotic pathwayBad , Bax , Bcl2 , Casp3 , Casp9 , Cycs
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Leishmaniasis pathwayFos , Jun , Mapk1 , Mapk3 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionBraf , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
malaria pathwayTgfb1 , Tgfb2 , Tgfb3
measles pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mismatch repair pathwayMlh1 , Msh2 , Msh3 , Msh6 , Pms1 , Pms2
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Casp3 , Fos , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Rac1 , Rac2 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
myocarditis pathwayCasp3 , Casp9 , Ccnd1 , Cycs , Cyct , Rac1 , Rac2
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Mapk8 , Pik3ca , Pik3r1 , Rac1 , Rhoa
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Braf , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa , RSA-14-44 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b
p38 MAPK signaling pathwayRac1
p53 signaling pathwayAkt1 , Bax , Casp3 , Casp9 , Ccnd1 , Cycs , Cyct , Gsk3b , Mapk8 , Mapk9 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
Parkinson's disease pathwayCasp3 , Casp9 , Cycs , Cyct
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rhoa
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayBraf , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
prion disease pathwayBax , Map2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Reelin signaling pathwayAkt1 , Gsk3b , Mapk8 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk10 , Mapk8 , Mapk9
rheumatoid arthritis pathwayFos , Jun , Tgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayJun , Mapk8 , Rac1 , Rhoa
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bcl2 , Casp9 , Ccnd1 , Cycs , Cyct , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Fos , Jun , Mapk1 , Mapk3 , Mapk8 , Rac1 , Rhoa
syndecan signaling pathwayBax , Casp3 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Rhoa , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Gsk3b , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rhoa , RSA-14-44
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Ctnnb1 , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayBax , Casp3 , Tp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayCasp3 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Cycs , Cyct , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Rhoa , RSA-14-44 , Tgfb1 , Tgfb2 , Tgfb3
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Smad7
urinary bladder cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Raf1 , Tp53
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rhoa
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Jun , Lef1 , Mapk10 , Mapk8 , Mapk9 , Myc , Rac1 , Rac2 , Rhoa , RSA-14-44 , Smad2 , Smad3 , Smad4 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9 , Rac1 , Rhoa
Wnt signaling, the planar cell polarity pathwayRac1 , Rhoa
Phenotype Annotations Associated with Genes in the colorectal cancer pathway

References Associated with the colorectal cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: