ENDOMETRIAL CANCER PATHWAY (PW:0000611)

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Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer-related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
RGD:13432140
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:6907045
RGD:13432145
G Apc2 APC2, WNT signaling pathway regulator JBrowse link 7 12,258,468 12,280,459 RGD:6907045
G Axin1 axin 1 RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6907045
RGD:13432159
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
RGD:13432162
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
RGD:13432196
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6907045
G Ctnna2 catenin alpha 2 JBrowse link 4 107,880,611 109,042,724 RGD:6907045
G Ctnna3 catenin alpha 3 JBrowse link 20 25,063,124 26,640,428 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:4143515
RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:4143515
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:4143515
RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:4143515
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:4143515
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:4143515
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the endometrial cancer pathway
Disease TermsGene Symbols
Aberrant Crypt FociApc , Ctnnb1 , Gsk3b , Mapk1 , Mapk3 , Myc
acinar cell carcinomaApc
acute kidney failureBad , Egf , Egfr , Gsk3b , Myc , Tp53
Acute Lung InjuryEgfr
acute lymphocytic leukemiaPten
acute myeloid leukemiaCcnd1 , Cdh1 , Ctnna1 , Hras , Kras , Myc , Nras , Tp53
acute promyelocytic leukemiaAkt1 , Myc , Nras
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaApc , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Kras , Myc , Pik3ca , Pten , Tcf7l2 , Tp53
adenoid cystic carcinomaCcnd1 , Cdh1 , Foxo3 , Hras , Kras , Map2k2 , Pik3ca , Pten , Tp53
adenomaApc , Ctnnb1 , Kras , Tp53
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
adrenal carcinomaBraf , Ctnnb1 , Nras , Pik3ca , Tp53
Adrenal Gland NeoplasmsCtnnb1 , Tp53
adrenocortical carcinomaBraf , Ctnnb1 , Egfr , Nras , Pik3ca , Tp53
adult respiratory distress syndromeApc
adult T-cell leukemiaNras , Tp53
agammaglobulinemiaPik3r1 , Tcf3
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Agammaglobulinemia 8, Autosomal DominantTcf3
AIDS-Associated NephropathyEgf
Alzheimer's diseaseAkt1 , Apc , Bad , Ctnnb1 , Egf , Egfr , Elk1 , Foxo3 , Gsk3b , Hras , Pik3r1 , Tp53
ameloblastomaBraf
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Bad , Casp9 , Gsk3b , Tp53
Anaplastic Thyroid CarcinomaTp53
anemiaKras
angiomyolipomaPten
angiosarcomaCcnd1 , Ctnnb1 , Hras , Kras , Myc , Tp53
Animal Disease ModelsAkt1 , Erbb2 , Kras , Lef1 , Mapk1 , Mapk3 , Myc , Tp53
anisometropiaPten
anodontiaAxin2
aortic valve diseaseEgfr
aortic valve stenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
arrhythmogenic right ventricular cardiomyopathyCtnna3
arrhythmogenic right ventricular dysplasia 13Ctnna3
Arsenic PoisoningTp53
arteriovenous malformations of the brainEgfr , Kras
asthmaCdh1 , Ctnna3 , Egfr , Pten
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Hras , Kras , Tp53
AtaxiaPten
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1
AtrophyMapk3
autism spectrum disorderMapk3
autistic disorderApc , Ctnnb1 , Egf , Hras , Mapk1 , Pten
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal dominant polycystic kidney diseaseMyc
autosomal recessive Alport syndromeHras
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive polycystic kidney diseaseAkt1 , Egfr , Myc , Pik3ca
B-Cell LeukemiaMyc
B-cell lymphomaNras
bacterial infectious diseaseCasp9
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePik3ca , Pten
Bardet-Biedl syndromeAkt3
basal cell carcinomaErbb2 , Pik3ca , Tp53
Bile Duct NeoplasmsEgfr
biliary atresiaPten
bipolar disorderAkt1 , Gsk3b
bladder carcinomaHras
bladder urothelial carcinomaAkt1 , Braf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Tp53
Blepharo-Cheilo-Dontic SyndromeCdh1
bone development diseaseTp53
Bone Marrow NeoplasmsTp53
brain diseasePten
Brain InjuriesAkt1 , Bad , Elk1 , Gsk3b
brain ischemiaAkt1 , Bad , Casp9 , Map2k1 , Mapk1 , Mapk3 , Tp53
Brain NeoplasmsBraf , Ccnd1 , Ctnnb1 , Egfr , Hras , Nras , Pik3ca , Pik3r1 , Pten , Tp53
breast adenocarcinomaAkt1 , Kras , Pik3ca , Tp53
breast cancerAkt1 , Apc , Braf , Cdh1 , Erbb2 , Grb2 , Hras , Kras , Myc , Pik3ca , Pten , Tp53
Breast Cancer, FamilialApc , Cdh1 , Pik3r3 , Tp53
Breast NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Erbb2 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mlh1 , Myc , Pdpk1 , Pik3ca , Pik3r1 , Pten , Raf1 , Tp53
bronchiolo-alveolar adenocarcinomaCcnd1 , Egfr , Kras , Tp53
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaMyc , Pik3r1 , Tcf3
BurnsBad , Ccnd1 , Gsk3b
Cafe au lait Spots, MultipleSos1
calcinosisCtnnb1 , Erbb2
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf , Erbb2 , Kras
carcinomaCcnd1 , Cdh1 , Egfr , Hras , Kras , Myc , Pik3r1 , Pten , Tp53
cardiac arrestAkt1
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Gsk3b , Mapk1 , Myc , Pten , Raf1
cardiomyopathyAkt1 , Ilk , Kras , Mapk1 , Mapk3 , Tp53
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionCtnna3
Cardiomyopathy, Hypertrophic, FamilialCtnna3 , Ilk , Kras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
carotid artery diseaseTp53
Carotid Artery InjuriesFoxo3 , Myc
cataractMap2k1 , Pten , Tp53
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCcnd1 , Ctnnb1 , Kras , Tp53
Cell Transformation, NeoplasticApc , Ccnd1 , Cdh1 , Egf , Hras , Kras , Myc , Pten , Tp53
Central Nervous System NeoplasmsTp53
cerebral cavernous malformationPten
cervical cancerTp53
cervix carcinomaTp53
cervix uteri carcinoma in situCcnd1 , Cdh1 , Ctnna1 , Mlh1 , Pten
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBad , Ctnnb1
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneEgfr
cholangiocarcinomaApc , Egfr , Erbb2 , Kras , Pten , Tp53
cholesteatoma of middle earTp53
choroid plexus carcinomaFoxo3 , Tp53
choroid plexus papillomaTp53
Chromosome 17 DeletionTp53
Chromosome BreakageMyc
chronic lymphocytic leukemiaBraf , Hras , Kras , Myc , Nras , Tp53
Chronic Lymphocytic Leukemia, B-CellBraf , Hras , Kras , Lef1 , Nras , Tp53
chronic myeloid leukemiaAkt1 , Braf , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseEgfr , Foxo3 , Tp53
clear cell adenocarcinomaTp53
clear cell renal cell carcinomaMyc
cleft lipCdh1 , Myc
cleft palateEgf , Myc
Cocaine-Related DisordersIlk , Mapk1 , Mapk3
Cognition DisordersGsk3b
colon adenocarcinomaApc , Mapk1 , Mapk3 , Pik3r3
colon cancerAkt1 , Apc , Braf , Cdh1 , Ctnnb1 , Mlh1 , Nras , Pik3ca , Tp53
colon carcinomaAkt1 , Apc , Axin2 , Braf , Ctnnb1 , Nras , Pik3ca , Tp53
Colonic NeoplasmsAkt2 , Akt3 , Apc , Axin2 , Bad , Braf , Ccnd1 , Ctnnb1 , Egfr , Erbb2 , Gsk3b , Kras , Lef1 , Mlh1 , Myc , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Pten , Tcf7l2 , Tp53
Colonic PolypsIlk
colorectal adenocarcinomaGsk3b , Mapk1 , Mapk3 , Raf1 , Tp53
colorectal adenomaApc , Raf1
colorectal cancerAkt1 , Apc , Axin2 , Braf , Ctnnb1 , Nras , Pik3ca , Tcf3 , Tcf7l2 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 1Mlh1
Colorectal NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Axin1 , Axin2 , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Pten , Raf1 , Tcf7l2 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Pik3ca
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congenital myasthenic syndrome 4CPten
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureErbb2 , Gsk3b , Pdpk1 , Tp53
coronary artery diseaseAkt1
Coronary DiseaseTcf7l2
coronary restenosisMapk1 , Myc , Tp53
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cowden diseaseAkt1 , Egfr , Pik3ca , Pten
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
Craniofacial AbnormalitiesCtnnb1 , Egfr , Pten , Tp53
craniopharyngiomaBraf , Ctnnb1
craniosynostosisAxin2
Crohn's diseaseTcf7
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Apc , Braf , Ctnnb1 , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Pten , Raf1 , Tp53
cutaneous T cell lymphomaBraf , Tp53
dementiaEgfr
demyelinating diseaseMyc , Tp53
dermatitisEgf , Egfr
dermoid cyst of ovaryFoxo3
developmental coordination disorderPten
Developmental DisabilitiesAkt3 , Braf , Mlh1 , Pik3r2 , Pten
diabetes mellitusPten , Tcf7l2
Diabetic CardiomyopathiesBad , Ctnnb1 , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pten , Tcf7l2 , Tp53
diabetic neuropathyBad
diabetic retinopathyCasp9 , Egfr , Hras
Diamond-Blackfan anemiaTp53
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd , Tp53
Digestive System NeoplasmsApc
dilated cardiomyopathyCtnna3 , Ctnnb1 , Egfr , Erbb2 , Ilk , Kras , Lef1 , Raf1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1NNRaf1
diseaseCtnnb1
disease of cellular proliferationApc , Braf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Pik3r1 , Pten , Tp53
Disease ProgressionCdh1 , Ctnnb1 , Egf , Egfr , Erbb2 , Hras , Myc , Pik3ca , Pten
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
ductal carcinoma in situCcnd1 , Erbb2 , Tp53
dysembryoplastic neuroepithelial tumorBraf
dyskeratosis congenitaTp53
dysplastic nevus syndromePten
EdemaCasp9
EmphysemaTp53
endodermal sinus tumorCtnnb1
endometrial cancerApc , Cdh1 , Egf , Pik3cb , Pik3r1 , Pten , Tp53
endometrial carcinomaApc , Cdh1 , Gsk3b , Kras , Mlh1 , Pik3ca , Pik3r1 , Pten
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsAkt2 , Apc , Axin2 , Bad , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Erbb2 , Foxo3 , Grb2 , Gsk3b , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pten , Tp53
Endometrioid CarcinomasAkt1 , Apc , Cdh1 , Ctnnb1 , Egfr , Erbb2 , Kras , Pik3r2 , Pten
endometriosisEgfr , Kras
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1 , Ilk
esophageal cancerTp53
esophageal carcinomaCtnnb1 , Egfr , Erbb2 , Hras , Kras , Myc , Pik3ca , Tp53
Esophageal NeoplasmsCcnd1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Myc , Pik3ca , Tp53
esophagus adenocarcinomaPik3ca , Tp53
esophagus squamous cell carcinomaCcnd1 , Ctnnb1 , Egfr , Tp53
Experimental ArthritisAkt1 , Egfr , Gsk3b , Nras , Pik3cd
Experimental Autoimmune EncephalomyelitisCasp9 , Foxo3
Experimental Diabetes MellitusAkt1 , Bad , Casp9 , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Myc , Pik3r1 , Tp53
Experimental Liver CirrhosisEgf , Ilk , Myc
Experimental NeoplasmsBraf , Ccnd1 , Cdh1 , Erbb2 , Hras , Kras , Nras , Tp53
Experimental SarcomaKras , Nras
extrahepatic cholestasisMapk1 , Mapk3
Exudative vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Eye AbnormalitiesApc
Facial AsymmetryPik3ca
familial adenomatous polyposisAkt1 , Apc , Egfr
familial hyperlipidemiaApc
familial meningiomaPten
familial partial lipodystrophyAkt2
Familial Prostate CancerCdh1
fatty liver diseaseMyc , Pten
Female InfertilityMapk1 , Mapk3 , Tp53
Femoral FracturesLef1
fetal alcohol spectrum disorderPten
Fetal Growth RetardationElk1
Fibromatosis, AbdominalApc
Fibromatosis, AggressiveApc
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1
Follicular Thyroid CancerBraf , Hras , Nras , Pten
follicular thyroid carcinomaBraf , Hras , Kras , Nras , Pten
fundus dystrophyCtnna1
Gallbladder NeoplasmsApc , Egf , Egfr , Erbb2 , Kras , Tp53
Gardner SyndromeApc
gastric adenocarcinomaAkt1 , Braf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mlh1 , Nras , Pik3ca , Pten , Raf1 , Tp53
gastric ulcerBad , Egf
Gastrointestinal HemorrhageApc
Gastrointestinal NeoplasmsApc , Erbb2 , Pik3ca , Pten
gastrointestinal stromal tumorBraf , Ctnna1 , Kras
Gaucher's diseaseTp53
genetic diseaseAkt2 , Akt3 , Axin2 , Braf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Pik3ca , Pik3r1 , Pik3r2 , Pten , Raf1 , Sos1
Genetic Predisposition to DiseaseEgf
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsErbb2 , Mlh1
germinomaBraf
gestational diabetesTcf7l2
Giant Pigmented Hairy NevusHras , Nras
gingival fibromatosisSos1
glaucomaBad
glioblastoma multiformeAkt1 , Akt3 , Apc , Braf , Egf , Egfr , Erbb2 , Hras , Myc , Nras , Pik3ca , Pik3r1 , Pten , Tp53
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
Gonadal Dysgenesis, XX Type, with DeafnessBraf
grade III astrocytomaTp53
Graft vs Host DiseaseTp53
granulosa cell tumorCtnnb1
Graves' diseaseTp53
Growth DisordersPik3ca
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsEgfr , Mapk1 , Mapk3 , Pik3ca , Tp53
head and neck squamous cell carcinomaAkt1 , Braf , Ccnd1 , Ctnnb1 , Egfr , Erbb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Pten , Tp53
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseCasp9
Helicobacter InfectionsCdh1
HELLP syndromeErbb2
hemangiomaPten
HemimegalencephalyPik3ca
hepatoblastomaApc , Ctnnb1 , Tp53
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
hepatocellular adenomaCtnnb1 , Hras , Kras , Pten
hepatocellular carcinomaAkt1 , Akt2 , Apc , Axin1 , Braf , Ccnd1 , Cdh1 , Ctnnb1 , Egf , Egfr , Hras , Kras , Myc , Nras , Pik3ca , Pten , Tp53
HepatomegalyPten
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeCdh1 , Mlh1 , Tp53
Hereditary Desmoid DiseaseApc , Ctnnb1
Hereditary Neoplastic SyndromesApc , Axin2 , Cdh1 , Ctnna1 , Mlh1 , Pik3ca , Pten , Tcf7 , Tp53
hereditary spastic paraplegia 11Tp53
Hirschsprung's diseaseErbb2
Huntington's diseaseCasp9 , Egfr , Elk1
Hydatidiform MoleMlh1
HyperalgesiaMapk1 , Mapk3 , Raf1
hyperinsulinismPten
HyperparathyroidismCcnd1 , Myc
HyperplasiaAkt1 , Apc , Ccnd1 , Egfr , Pik3ca , Tcf7l2
Hypersensitivity, ImmediateEgfr
hypertensionAkt1 , Akt2 , Bad , Egfr , Gsk3b , Kras , Pik3r1 , Pten , Tp53
hypertrophic cardiomyopathyCtnnb1 , Myc , Raf1 , Tp53
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Foxo3 , Myc , Pten
Hypertrophy, Right VentricularAkt1
hypoglycemiaAkt2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypothyroidismBad
Hypoxia-Ischemia, BrainFoxo3
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
imperforate anusCtnnb1
impotenceAkt1 , Bad , Ccnd1
in situ carcinomaAkt1 , Ctnnb1 , Pten
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaEgf
InflammationAkt1 , Egfr
inflammatory bowel diseaseApc , Apc2
Insulin ResistanceAkt2 , Bad , Egfr , Pik3r1 , Pten , Tcf7l2
intellectual disabilityApc , Kras , Pten
intermediate coronary syndromeAkt1
intermittent claudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsApc , Ctnnb1 , Gsk3b , Map2k1 , Map2k2
Intestinal PolypsApc , Ccnd1
intestinal pseudo-obstructionPten
Intimal HyperplasiaFoxo3
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Cdh1 , Erbb2
invasive lobular carcinomaCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Erbb2
ischemiaAkt2 , Raf1 , Tp53
Joubert syndrome 9Braf
juvenile myelomonocytic leukemiaKras , Nras
juvenile rheumatoid arthritisEgf , Kras , Mapk1 , Tcf7l2
Kaposi's sarcomaTp53
keratosisTp53
kidney diseaseEgf , Mapk1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Erbb2 , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryMyc
Klinefelter's syndromeNras
L-2-hydroxyglutaric aciduriaSos2
Language Development DisordersPten
Laryngeal NeoplasmsEgfr
Leber hereditary optic neuropathyTp53
leiomyomaMyc , Pten
LEOPARD syndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaBad , Ccnd1 , Nras , Pten , Tp53
Leukemia, ExperimentalNras
LeukocytosisApc , Kras , Nras
Lewy body dementiaElk1
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni Syndrome 3Tp53
Li-Fraumeni-Like SyndromeTp53
Lip NeoplasmsTp53
lipomaPten
lipomatosisPten
Lipoyltransferase 1 DeficiencyTp53
liver cancerAkt1 , Apc , Axin1 , Ctnnb1 , Hras , Kras , Nras , Pik3ca , Tp53
liver cirrhosisCtnnb1
Liver InjuryMyc
liver neoplasmApc , Braf , Ccnd1 , Ctnnb1 , Hras , Kras , Myc , Raf1 , Tp53
Liver Neoplasms, ExperimentalCcnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Tp53
Liver Reperfusion InjuryBad
long QT syndromeCtnna3 , Ilk , Pten
low tension glaucomaTp53
lung adenocarcinomaAkt1 , Apc , Braf , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Foxo3 , Hras , Kras , Map2k1 , Mlh1 , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1 , Tp53
lung cancerBraf , Egfr , Erbb2 , Kras , Pik3ca
lung diseaseEgfr
Lung NeoplasmsAkt1 , Apc , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pten , Raf1 , Tp53
Lung Reperfusion InjuryMyc
lung small cell carcinomaAkt1 , Ccnd1 , Egfr , Pik3ca , Pten , Tp53
lung squamous cell carcinomaAkt1 , Braf , Ccnd1 , Ctnnb1 , Egfr , Hras , Kras , Pik3ca , Pten , Tp53
lupus nephritisEgf
LymphangiectasisRaf1
Lymphatic MetastasisCasp9 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Pdpk1 , Pik3ca , Pik3cb , Pten , Tp53
lymphomaKras , Mlh1 , Nras , Pten , Tp53
Lynch syndromeApc , Mlh1
Lynch Syndrome IIMlh1
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macrocytic anemiaApc
macular degenerationBad
male infertilityTp53
Malformations of Cortical Development, Group IIPten
malignant gliomaAkt2 , Bad , Braf , Ccnd1 , Egfr , Erbb2 , Hras , Pik3ca , Pten , Raf1 , Tp53
malignant mesotheliomaCtnnb1 , Egfr , Ilk , Raf1 , Tp53
Mammary Neoplasms, AnimalApc , Ccnd1 , Cdh1 , Egfr , Erbb2 , Hras , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Cdh1 , Ctnnb1 , Egfr , Erbb2 , Hras , Ilk , Myc , Pik3r1 , Pten , Tp53
mammary Paget's diseaseErbb2
Mandibular NeoplasmsBraf , Ctnnb1
mantle cell lymphomaCcnd1 , Ctnnb1 , Gsk3b , Pik3cd
marginal zone B-cell lymphomaTp53
median neuropathyErbb2
medulloblastomaApc , Ccnd1 , Ctnnb1 , Erbb2 , Foxo3 , Myc , Nras , Pik3ca , Tp53
Megakaryoblastic Leukemia of Down SyndromeNras , Tp53
megakaryocytic leukemiaPten , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Apc , Braf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Myc , Nras , Pik3ca , Pik3r1 , Pten , Raf1 , Tp53
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pten
mental depressionGsk3b
Merkel cell carcinomaMyc
MesotheliomaApc , Cdh1 , Egfr , Tp53
MetaplasiaAxin2 , Egf
Microphthalmia, Syndromic 1Cdh1
Microsatellite InstabilityBraf
middle cerebral artery infarctionBad
migraineMap2k2
Monoclonal B-Cell LymphocytosisApc
Mouth NeoplasmsErbb2 , Hras , Kras , Nras , Pik3ca , Pten , Tp53
mucoepidermoid carcinomaCdh1
Muir-Torre syndromeMlh1
Multiple AbnormalitiesCtnnb1 , Gsk3b , Kras , Mapk1 , Pik3r2 , Pten
Multiple Hamartoma SyndromePik3ca , Pten
multiple myelomaBraf , Ccnd1 , Hras , Kras , Nras , Pik3ca , Tp53
Multiple Organ FailureMapk1
muscular atrophyAkt1 , Ctnnb1 , Gsk3b
muscular dystrophyPten
Mycoplasma InfectionsCdh1
myelodysplastic syndromeCtnna1 , Hras , Kras , Myc , Nras , Tp53
myelofibrosisTp53
myeloid neoplasmKras , Nras
myeloid sarcomaKras
myocardial infarctionAkt1 , Gsk3b , Mapk1 , Tp53
Myocardial IschemiaCcnd1 , Erbb2
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Gsk3b , Mapk1 , Pten , Tp53
Myoclonus, Familial CorticalMyc
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Hras , Nras , Pik3ca , Tp53
nasopharynx carcinomaAkt2 , Ccnd1 , Erbb2 , Kras , Pik3ca , Pten , Tp53
Nematode InfectionsPik3r1
Neonatal Inflammatory Skin and Bowel Disease 2Egfr
Neoplasm InvasivenessCdh1 , Ctnnb1 , Egf , Egfr , Hras , Lef1 , Mapk1 , Mapk3 , Pten
Neoplasm MetastasisAkt2 , Braf , Ccnd1 , Cdh1 , Ctnnb1 , Egf , Egfr , Erbb2 , Kras , Lef1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3r3 , Pten , Tcf3 , Tp53
Neoplasm Recurrence, LocalEgfr , Erbb2
Neoplasm SeedingCdh1
Neoplasms, Multiple PrimaryMlh1
Neoplastic ProcessesHras
nephroblastomaCtnnb1 , Erbb2 , Myc , Tp53
Nerve DegenerationCdh1 , Ctnnb1 , Mapk1 , Mapk3
Nerve Sheath NeoplasmsPten , Tp53
nervous system diseaseCasp9 , Tp53
neuroblastomaHras , Kras , Myc , Nras , Pik3ca , Tp53
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersCtnnb1 , Pten , Tcf7l2
neuroectodermal tumorMyc
neuroendocrine tumorBraf
neurofibrosarcomaNras
neuronal ceroid lipofuscinosisBraf
neuronal ceroid lipofuscinosis 6Braf , Gsk3b , Mapk1 , Mapk3
NevusBraf
Nevus, PigmentedNras
No-Reflow PhenomenonCtnnb1
non-Hodgkin lymphomaBraf , Ccnd1 , Map2k1 , Myc , Nras , Pik3ca , Tp53
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Apc , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Hras , Kras , Map2k1 , Myc , Nras , Pdpk1 , Pik3ca , Pten , Raf1 , Tp53
Nonseminomatous Germ Cell TumorBraf
Noonan Like SyndromeSos1
Noonan syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras
Noonan syndrome 3Hras , Kras , Raf1 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
Nose NeoplasmsTp53
obesityAkt1 , Akt2 , Bad , Egfr , Foxo3 , Myc , Pik3r1
obsessive-compulsive disorderHras
Odontogenic MyxomaTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
Oral Lichen PlanusTp53
oral mucosa leukoplakiaTp53
oral submucous fibrosisTp53
Orofacial Cleft 1Cdh1
Oropharyngeal NeoplasmsTp53
osteoarthritisBad
Osteoarthritis, KneeCtnnb1
osteochondrodysplasiaPten
osteoporosisMyc
osteosarcomaAkt1 , Egfr , Myc , Tp53
ovarian cancerAkt1 , Apc , Cdh1 , Ctnnb1 , Egf , Erbb2 , Kras , Mlh1 , Pik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Gsk3b , Hras , Ilk , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3r1 , Pten , Tp53
ovarian serous cystadenocarcinomaBraf , Erbb2 , Hras , Nras , Pik3ca , Tp53
ovary adenocarcinomaErbb2
ovary epithelial cancerTp53
PainAkt1
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaCcnd1 , Ctnnb1 , Erbb2 , Hras , Kras , Map2k2 , Pik3ca , Tp53
pancreatic cancerAkt1 , Akt2 , Akt3 , Apc , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnnb1 , Egf , Egfr , Ilk , Kras , Myc , Pten , Tcf7l2 , Tp53
pancreatic carcinomaKras , Myc , Tp53
pancreatic ductal adenocarcinomaCcnd1
pancreatic ductal carcinomaCcnd1 , Egf , Kras
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisEgf
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
Papillary Thyroid CancerBraf
papillary thyroid carcinomaBraf
papillomaCcnd1 , Egfr , Erbb2 , Hras
paranasal sinus neoplasmTp53
paraplegiaAkt1
Parasitic Liver DiseasesKras , Tp53
Parkinson's diseaseAkt1 , Casp9 , Egf , Egfr , Erbb2 , Gsk3b
Parkinsonian DisordersBad , Casp9 , Egfr
patterned macular dystrophyCtnna1
patterned macular dystrophy 2Ctnna1
Pediatric Adrenocortical CarcinomaTp53
Pena Shokeir Syndrome, Type 1Pten
penile neoplasmCcnd1 , Hras , Kras , Pik3ca , Tp53
peptic esophagitisEgfr
periampullary adenomaApc
perinatal necrotizing enterocolitisEgf
peripheral nervous system diseaseCasp9
peripheral nervous system neoplasmPten
Peritoneal NeoplasmsCtnnb1
peritonitisGsk3b
persistent fetal circulation syndromePten
phobic disorderHras
Phyllodes TumorCtnnb1 , Egfr , Tp53
pilocytic astrocytomaKras
pilomatrixomaCtnnb1
plasmacytomaBraf , Hras , Kras , Nras , Pik3ca , Tp53
pleomorphic xanthoastrocytomaBraf , Egfr
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaEgf
PoisoningGsk3b
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
polycystic ovary syndromeAkt2
polydactylyPten
PolymicrogyriaAkt3
PolyploidyTp53
Polyposis, GastricApc
portal hypertensionPik3r1 , Pten
pre-eclampsiaErbb2
pre-malignant neoplasmAkt1 , Ccnd1 , Cdh1 , Egf , Hras , Tp53
precursor B lymphoblastic lymphoma/leukemiaCcnd1 , Tcf3 , Tp53
precursor lymphoblastic lymphoma/leukemiaCcnd1 , Kras , Myc , Nras , Tcf3 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaKras
Premature AgingTp53
primary hypomagnesemiaEgf
primary open angle glaucomaTp53
Progressive Osseous HeteroplasiaCtnnb1
prolactinomaMyc
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Ctnnb1 , Erbb2 , Grb2 , Hras , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Pten , Raf1 , Tp53
prostate cancerAkt2 , Akt3 , Apc , Cdh1 , Ctnnb1 , Erbb2 , Grb2 , Kras , Lef1 , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pten , Raf1 , Sos1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Prostate Cancer, SomaticPten
prostate carcinomaAkt2
prostate carcinoma in situCcnd1 , Cdh1 , Kras , Lef1 , Myc , Pten
prostatic hypertrophyBad , Myc , Pten
Prostatic NeoplasmsAkt1 , Apc , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Erbb2 , Foxo3 , Gsk3b , Hras , Ilk , Kras , Map2k1 , Mapk3 , Mlh1 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pten , Tp53
Proteus syndromeAkt1 , Pten
psoriasisTp53
PTEN hamartoma tumor syndromePik3ca , Pten
pterygiumTp53
pulmonary fibrosisBad , Cdh1 , Egf , Egfr
pulmonary hypertensionEgfr , Myc , Tp53
pulmonary valve stenosisBraf , Hras , Sos1
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
rectal neoplasmApc , Egfr , Nras , Pik3ca , Pik3cb
RecurrenceErbb2 , Hras , Kras
renal carcinomaNras , Pik3ca , Pten , Tp53
renal cell carcinomaAkt1 , Akt3 , Apc , Bad , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mlh1 , Myc , Nras , Pik3ca , Pik3r1 , Pten , Tp53
renal fibrosisKras , Mapk1 , Myc
renal hypomagnesemia 3Egf
renal hypomagnesemia 4Egf
renal hypomagnesemia 5 with ocular involvementEgf
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Egf , Pik3r1 , Pten , Tp53
Retina Reperfusion InjuryBad
retinal detachmentCasp9
retinitis pigmentosaPten
rhabdoid cancerMyc
rhabdomyosarcomaTp53
rheumatoid arthritisFoxo3
Salivary Gland NeoplasmsCcnd1 , Cdh1
sarcomaPik3ca , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
schizophreniaAkt1 , Egf , Egfr , Elk1 , Gsk3b , Mapk3 , Pik3cb , Tp53
sebaceous gland neoplasmLef1
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
seminomaHras , Kras
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisBad , Gsk3b , Mapk1 , Mapk3
Septic PeritonitisPik3r1
serous cystadenocarcinomaTp53
Serrated PolyposisApc
Sezary's diseaseBraf , Mapk1 , Pten , Tp53
Shock, HemorrhagicBad , Mapk1 , Myc
SHORT SyndromePik3r1
skin benign neoplasmHras
skin diseasePten
skin melanomaPten
Skin NeoplasmsAkt1 , Ctnnb1 , Hras , Tp53
small cell carcinomaTp53
Small-For-Size SyndromeBad
Smith-Magenis syndromeAxin2 , Erbb2 , Grb2 , Map2k2
SOTOS SYNDROME 3Apc2
spermatocytomaHras
Spinal Cord InjuriesAkt1 , Egfr , Foxo3 , Tp53
Spinal Cord Reperfusion InjuryBad
Splenic NeoplasmsHras
SplenomegalyApc , Kras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Erbb2 , Hras , Myc , Pik3ca , Tp53
squamous cell carcinomaAkt1 , Ccnd1 , Cdh1 , Egfr , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Tp53
status epilepticusCcnd1 , Foxo3 , Gsk3b
Stevens-Johnson syndromeCtnnb1
stomach cancerApc , Cdh1 , Erbb2 , Kras , Pik3ca
stomach diseasePten
Stomach NeoplasmsApc , Ccnd1 , Cdh1 , Ctnna2 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Tp53
StrokeAkt1 , Ctnnb1 , Pik3ca
substance-induced psychosisAkt1
substance-related disorderCtnna3 , Pten
systemic lupus erythematosusTcf7
T-Cell LymphomaAkt1 , Tp53
Tachycardia, VentricularRaf1
tauopathyGsk3b
temporal lobe epilepsyFoxo3
teratomaCtnnb1
thoracic diseaseIlk
thrombosisPik3cb
thymomaHras , Tp53
Thymus NeoplasmsTp53
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Hras , Kras , Nras , Pik3ca , Pten , Tp53
Tobacco Use DisorderEgfr
Tongue NeoplasmsHras , Tp53
tongue squamous cell carcinomaEgfr , Tp53
tooth agenesisAxin2
transient cerebral ischemiaBad , Casp9 , Elk1 , Ilk , Pten
transitional cell carcinomaAkt1 , Apc , Braf , Ccnd1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Map2k1 , Mapk1 , Nras , Pik3ca , Pten , Tp53
Transplant RejectionMyc
Trichilemmoma Hras
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaMapk1 , Mapk3
Tumor Predisposition SyndromeApc , Cdh1 , Mlh1 , Pten , Tp53
Turcot SyndromeApc , Mlh1
type 1 diabetes mellitusCasp9 , Egfr
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Braf , Casp9 , Egfr , Gsk3b , Mapk1 , Mapk3 , Pik3cb , Pik3r1 , Tcf7l2
ulcerative colitisCdh1
ureteral obstructionAkt1
urethral obstructionMapk1
urinary bladder cancerAkt1 , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mlh1 , Myc , Pten , Tp53
Urinary Bladder NeoplasmHras , Kras
Urinary IncontinenceMapk1
Urogenital NeoplasmsTp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53
uterine carcinosarcomaErbb2 , Hras , Pik3ca , Pik3r1 , Pten , Tp53
Uterine Cervical NeoplasmsAkt1 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mapk1 , Mlh1 , Myc , Nras , Pik3ca , Pten , Sos1 , Tp53
Uterine NeoplasmsBraf , Ctnnb1 , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Pten , Sos1 , Tp53
VACTERL associationPten
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9
Vascular CalcificationCtnnb1
vascular dementiaTp53
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1
ventricular septal defectBraf
visual epilepsyBad , Ccnd1 , Pik3ca , Pten
vitiligoPik3r1
von Hippel-Lindau diseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsMlh1 , Tp53
Wallerian DegenerationErbb2
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
withdrawal disorderMapk1 , Mapk3
Wounds and InjuriesEgf
xeroderma pigmentosumTp53
Zollinger-Ellison syndromeEgf
Pathway Annotations Associated with Genes in the endometrial cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk
altered mismatch repair pathwayMlh1
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer's disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cetuximab pharmacodynamics pathwayEgfr
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cytokine mediated signaling pathwayEgf , Egfr
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk , Pdpk1
endocytosis pathwayEgf , Egfr , Hras
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Egf , Egfr , Elk1 , Erbb2 , Foxo3 , Grb2 , Gsk3b , Hras , Ilk , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Cdh1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
gonadotropin-releasing hormone signaling pathwayEgfr , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
Huntington's disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1 , Elk1
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
integrin mediated signaling pathwayIlk
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmaniasis pathwayElk1 , Mapk1 , Mapk3
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
measles pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdh1 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tp53
mismatch repair pathwayMlh1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Sos1 , Sos2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayAxin1 , Ctnna1 , Ctnnb1 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b , Pten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson's disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Elk1 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1
prion disease pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
protein kinase C (PKC) signaling pathwayPdpk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Pik3r1
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Mapk1 , Mapk3
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Tcf3 , Tcf7 , Tcf7l2 , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc
trastuzumab pharmacodynamics pathwayEgfr
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
urinary bladder cancer pathwayBraf , Ccnd1 , Cdh1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Tp53
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnna1 , Ctnnb1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Lef1 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Phenotype Annotations Associated with Genes in the endometrial cancer pathway

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: