PROSTATE CANCER PATHWAY (PW:0000609)

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Description

Prostate neoplasm is a common form of cancer affecting about 1 in 5 men. Normal as well as malignant prostate tissues rely on the action of androgen hormones for growth and proliferation. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. In some of the target cells, testosterone can be converted to its very potent metabolite dehydrotestosterone (DHT). Testosterone and DH

Pathway Diagram:

Elsevier Inc. upregulated target translation downregulated target translation Prostatic Neoplasms altered p53 signaling pathway ---> altered expression of target genes gene fusion events ---> Prostatic Neoplasms androgen independent Ar activity ---> altered expression of target genes androgen independent Ar activity altered androgen signaling pathway ---> androgen independent Ar activity gene fusion events Tp53 altered p53 signaling pathway donwregulated miRNA altered expression of target genes upergulated miRNA Ncor2 Ncoa2 Ar altered androgen signaling pathway donwregulated miRNA ---> upregulated target translation potential PC miRNA ---> Prostatic Neoplasms upergulated miRNA ---> downregulated target translation potential PC miRNA Pten Pik3ca altered androgen signaling pathway ---> increased Ar activity increased Ar activity altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes increased Ar activity ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes
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Genes in Pathway:

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prostate cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
RGD:6907045
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6907045
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6907045
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6907045
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6907045
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6907045
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:6907045
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:6907045
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:6907045
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6907045
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6907045
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6907045
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6907045
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6907045
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6907045
G Nkx3-1 NK3 homeobox 1 JBrowse link 15 51,065,316 51,067,908 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pdgfc platelet derived growth factor C JBrowse link 2 179,952,227 180,126,897 RGD:6907045
G Pdgfd platelet derived growth factor D JBrowse link 8 4,441,010 4,666,754 RGD:6907045
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6907045
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
RGD:8693397
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2326139
RGD:8693397
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
RGD:8693397

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered p53 signaling pathway
Gene Grouppotential PC miRNA
Diseaseprostatic neoplasms
Pathwayaltered androgen signaling pathway
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the prostate cancer pathway
Disease TermsGene Symbols
16p11.2 Deletion SyndromeMapk3
abdominal obesity-metabolic syndrome 1Bcl2
Aberrant Crypt FociCtnnb1 , Gsk3b , Mapk1 , Mapk3
Abortion, SpontaneousIgf1
acneIgf1
Acneiform EruptionsFgfr2
acoustic neuromaCdkn1a , Fgfr1 , Igf1
acrocephalosyndactyliaFgfr1 , Fgfr2
acromegalyIgf1
Acute Coronary SyndromeGstp1
acute kidney failureAr , Bad , Bcl2 , Cdkn1b , Egf , Egfr , Gsk3b , Gstp1 , Igf1 , Igf1r , Ins2 , Mtor , Nfkb1 , Rb1 , Tgfa , Tp53
Acute Liver FailureCasp9 , Ins1 , Ins2
Acute Lung InjuryBcl2 , Egfr
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesFgfr1
acute lymphocytic leukemiaPten
acute myeloid leukemiaBcl2 , Ccnd1 , Cdkn1b , Crebbp , Fgfr1 , Foxo1 , Gstp1 , Hras , Kras , Mdm2 , Ncoa2 , Nras , Tp53
acute myocardial infarctionGsk3b
Acute Necrotizing PancreatitisNfkbia , Rela
acute promyelocytic leukemiaAkt1 , Nras
adenocarcinomaBcl2 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Kras , Mtor , Nfkb1 , Pik3ca , Pten , Tcf7l2 , Tp53
adenoid cystic carcinomaCcnd1 , Crebbp , Ep300 , Fgfr2 , Hras , Insrr , Kras , Map2k2 , Pik3ca , Pten , Tp53
adenomaBcl2 , Ctnnb1 , Igf1 , Ins2 , Kras , Tp53
adrenal carcinomaBraf , Ctnnb1 , Nras , Pik3ca , Tp53
Adrenal Gland NeoplasmsCtnnb1 , Rb1 , Tp53
Adrenal InsufficiencyBcl2
adrenocortical carcinomaBraf , Ctnnb1 , Egfr , Igf1r , Nras , Pik3ca , Rb1 , Tp53
adult T-cell leukemiaNras , Tp53
agammaglobulinemiaPik3r1 , Tcf3
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Agammaglobulinemia 8, Autosomal DominantTcf3
AIDS Dementia ComplexPdgfb
AIDS-Associated NephropathyEgf , Mtor
AIDS-Related Kaposi SarcomaBcl2
Airway ObstructionGstp1
AlbuminuriaIgf1 , Ins2
alcoholic liver cirrhosisBcl2 , Rela
alcoholic neuropathyIgf1 , Igf1r
allergic contact dermatitisBcl2
allergic hypersensitivity diseaseGstp1
allergic rhinitisBcl2
alopeciaAr , Igf1 , Srd5a2
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseAkt1 , Bad , Bcl2 , Casp9 , Crebbp , Ctnnb1 , E2f1 , Egf , Egfr , Ep300 , Fgfr1 , Gsk3b , Gstp1 , Hras , Hsp90aa1 , Igf1 , Igf1r , Ikbkb , Ins1 , Ins2 , Mapk1 , Mapk3 , Pdgfb , Pik3r1 , Tp53
ameloblastomaBraf
amphetamine abuseAkt1 , Gstp1 , Rela
amyotrophic lateral sclerosisAkt1 , Bad , Bcl2 , Casp9 , Gsk3b , Gstp1 , Igf1r , Tp53
amyotrophic lateral sclerosis type 1Crebbp , Pdgfa
anaplastic large cell lymphomaHsp90aa1
Anaplastic Thyroid CarcinomaTp53
androgen insensitivity syndromeAr
Androgen Insensitivity Syndrome due to Coactivator DeficiencyAr
anemiaKras
angiomyolipomaPten
angiosarcomaCcnd1 , Ctnnb1 , Hras , Kras , Tp53
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsAkt1 , Erbb2 , Kras , Lef1 , Mapk1 , Mapk3 , Tp53
Animal Mammary NeoplasmsCcnd1 , Cdkn1a , Egfr , Erbb2 , Hras , Pdgfa , Pik3r1 , Rb1 , Tgfa
anisometropiaPten
ankylosisFgfr2
Anorectal MalformationsFgfr2
anti-basement membrane glomerulonephritisBcl2
Antley-Bixler syndromeFgfr2
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISFgfr2
aortic valve diseaseEgfr
aortic valve stenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arsenic PoisoningCdkn1a , Tp53
arteriosclerosisIgf1 , Rela
arteriovenous malformations of the brainEgfr , Kras
asthmaBcl2 , Chuk , Egfr , Gstp1 , Pdgfb , Pten
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Ar , Braf , Ccnd1 , Fgfr1 , Gstp1 , Hras , Kras , Tp53
AtaxiaPten
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Pdgfrb
atopic dermatitisGstp1 , Nfkbia
atrial fibrillationCdkn1a , Igf1r
atrial heart septal defectCrebbp
AtrophyMapk3
attention deficit hyperactivity disorderAr , Crebbp
atypical chronic myeloid leukemiaFgfr1
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autism spectrum disorderMap2k1 , Mapk3 , Pten
autistic disorderAr , Bcl2 , Crebbp , Ctnnb1 , Egf , Egfr , Gstp1 , Hras , Igf1 , Ikbkg , Map2k1 , Mapk1 , Mapk3 , Pten
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autosomal dominant non-syndromic intellectual disability 18Creb3l4
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal dominant polycystic kidney diseaseCdkn1a , Mtor
autosomal recessive Alport syndromeHras
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive limb-girdle muscular dystrophy type 2JPdgfra
autosomal recessive polycystic kidney diseaseAkt1 , Egfr , Mtor , Pik3ca
azoospermiaBcl2
B-Cell Chronic Lymphocytic LeukemiaBcl2 , Braf , Hras , Kras , Lef1 , Nras , Tp53
B-Cell CLL/Lymphoma 2Bcl2
B-cell lymphomaNras
background diabetic retinopathyPdgfb
bacterial infectious diseaseCasp9
bacterial pneumoniaChuk
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePik3ca , Pten
Bardet-Biedl syndromeAkt3
Barrett's esophagusCdkn1a , Rela
basal cell carcinomaErbb2 , Pik3ca , Rb1 , Tp53
basal ganglia calcificationPdgfb , Pdgfrb
basal ganglia diseasePdgfb , Pdgfrb
Beare-Stevenson cutis gyrata syndromeFgfr2
Behcet's diseaseIkbkg
Bent Bone Dysplasia SyndromeFgfr2
Bile Duct NeoplasmsEgfr
biliary atresiaPten
biliary tract benign neoplasmMdm2
bilirubin metabolic disorderBcl2
bipolar disorderAkt1 , Gsk3b , Ins2
bladder carcinomaHras
bladder diseaseIns2
bladder urothelial carcinomaAkt1 , Braf , Crebbp , Ctnnb1 , Ep300 , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pten , Tp53
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk , Tp53
bone marrow diseaseGstp1
Bone Marrow Failure Syndrome 5Tp53
Bone Marrow NeoplasmsTp53
Bone MetastasisPdgfd
Bowen's DiseaseCcne1 , Cdkn1a
brain diseasePten
brain gliomaBcl2
Brain HypoxiaEp300
brain infarctionPdgfb
Brain InjuriesAkt1 , Bad , Bcl2 , Cdkn1a , Cdkn1b , Gsk3b , Igf1 , Mdm2 , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Rela
Brain Injuries, TraumaticBad
brain ischemiaAkt1 , Bad , Bcl2 , Casp9 , Creb1 , Igf1 , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Rb1 , Rela , Tp53
Brain NeoplasmsBraf , Ccnd1 , Ctnnb1 , Egfr , Hras , Nras , Pik3ca , Pik3r1 , Pten , Rela , Tp53
brain stem gliomaPdgfra
breast adenocarcinomaAkt1 , Ccne1 , Kras , Pik3ca , Tp53
breast cancerAkt1 , Bad , Braf , Casp9 , Ccne1 , Cdk2 , Cdkn1b , Egfr , Erbb2 , Fgfr2 , Grb2 , Gstp1 , Hras , Igf1 , Igf1r , Ikbkb , Kras , Map2k1 , Map2k2 , Mapk1 , Mdm2 , Mtor , Ncor2 , Nfkb1 , Pdgfa , Pdgfrb , Pik3ca , Pten , Tp53
Breast Cancer, FamilialPik3ca , Pik3r3 , Tp53
breast carcinomaEgfr , Ep300 , Pdgfra , Pdgfrb , Srd5a2
Breast NeoplasmsAkt1 , Akt2 , Ar , Bcl2 , Braf , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Ctnnb1 , E2f1 , Egf , Egfr , Ep300 , Erbb2 , Fgfr1 , Fgfr2 , Gstp1 , Hras , Hsp90aa1 , Igf1 , Igf1r , Kras , Lef1 , Mdm2 , Mtor , Ncoa2 , Nfkbia , Pdgfa , Pdgfrb , Pdpk1 , Pik3ca , Pik3r1 , Pten , Raf1 , Rb1 , Rela , Tp53
bronchiolo-alveolar adenocarcinomaCcnd1 , Egfr , Gstp1 , Kras , Tp53
Bronchopulmonary DysplasiaCasp9 , Gstp1 , Tp53
bronchus carcinomaGstp1
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1 , Tcf3
BurnsBad , Bcl2 , Ccnd1 , Fgfr1 , Gsk3b , Igf1 , Igf1r , Mtor
Burns, ChemicalFgfr2
Cafe au lait Spots, MultipleSos1
calcinosisCtnnb1 , Erbb2 , Pdgfb , Pdgfrb
cancerBraf , Erbb2 , Hras , Nras , Pik3ca , Pik3r1 , Pten , Tp53
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf , Erbb2 , Kras
carcinomaBcl2 , Ccnd1 , Cdkn1a , Egfr , Gstp1 , Hras , Kras , Pdgfa , Pik3r1 , Pten , Rb1 , Tp53
Cardiac Allograft VasculopathyPdgfd
cardiac arrestAkt1 , Ep300 , Ins2
Cardiac FibrosisNfkbia
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Ep300 , Gsk3b , Igf1 , Igf1r , Mapk1 , Mtor , Pdgfrb , Pten , Raf1 , Rb1 , Rela
cardiomyopathyAkt1 , Ep300 , Igf1r , Kras , Mapk1 , Mapk3 , Tp53
CardiotoxicityTp53
Cardiovascular AbnormalitiesMap2k1
carotid artery diseaseGstp1 , Igf1 , Tp53
Carotid Artery InjuriesIgf1 , Igf1r , Pdgfd
Castration-Resistant Prostatic NeoplasmsAr , Ccne2
cataractCasp9 , Map2k1 , Pten , Tp53
Cecal NeoplasmsCcnd1 , Ctnnb1 , Kras , Tp53
Cell Transformation, NeoplasticBcl2 , Ccnd1 , Ctnnb1 , Egf , Gsk3b , Hras , Igf1r , Kras , Mdm2 , Nfkb1 , Pten , Rela , Tp53
central nervous system diseaseCrebbp
Central Nervous System NeoplasmsTp53
cerebral cavernous malformationPten
Cerebral HemorrhageBcl2 , Casp9 , Mtor , Nfkb1 , Nfkbia , Rela
cervical adenocarcinomaTp53
cervical cancerNras , Sos1 , Tp53
cervical squamous cell carcinomaTp53
cervix carcinomaTp53
cervix uteri carcinoma in situBcl2 , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Pten , Rb1 , Rela
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBad , Ctnnb1 , Gstp1 , Igf1
Chemotherapy-Induced Febrile NeutropeniaGstp1 , Mdm2 , Tp53
childhood pilocytic astrocytomaMapk1
Childhood SchizophreniaRela
ChloracneCdkn1b , Egfr
cholangiocarcinomaEgfr , Erbb2 , Fgfr2 , Gstp1 , Kras , Mdm2 , Pten , Tp53
CholangiofibrosisGstp1
cholestasisGstp1 , Igf1 , Pdgfb , Rela
cholesteatoma of middle earCdkn1a , Rela , Tp53
chondrosarcomaMtor
choriocarcinomaPdgfb , Pdgfrb
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Choroidal NeovascularizationIgf1r , Ikbkb
Chromosome 13q Deletion SyndromeRb1
chromosome 13q14 deletion syndromeRb1
Chromosome 17 DeletionTp53
Chromosome AberrationsGstp1
Chronic Allograft DysfunctionMtor
Chronic Allograft NephropathyPdgfa , Pdgfb , Pdgfra , Pdgfrb
Chronic Cerebral HypoperfusionGstp1
Chronic Intermittent HypoxiaBcl2
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras , Tp53
chronic myeloid leukemiaAkt1 , Braf , Cdkn1b , E2f1 , Gstp1 , Mdm2 , Nras
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseEgfr , Gstp1 , Tp53
Chronic PancreatitisBad
chronic ulcer of skinPdgfa , Pdgfra
clear cell adenocarcinomaBcl2 , Tp53
clear cell renal cell carcinomaEp300 , Gstp1 , Igf1r , Pdgfb
cleft lipFgfr1 , Fgfr2
cleft palateChuk , Egf , Fgfr1 , Fgfr2 , Pdgfra
CLOVES syndromePik3ca
Cocaine-Related DisordersCreb1 , Mapk1 , Mapk3
Cockayne syndromeIgf1
cocoon syndromeChuk
cognitive disorderGsk3b , Ins2
Cognitive DysfunctionHsp90aa1 , Tp53
colitisChuk , Igf1 , Ikbkb , Rela
colon adenocarcinomaCtnnb1 , Mapk1 , Mapk3 , Pik3ca , Pik3r3
colon cancerAkt1 , Akt3 , Bad , Bcl2 , Braf , Ctnnb1 , Gsk3b , Ikbkb , Nras , Pik3ca , Pik3r2 , Pik3r5 , Pten , Tp53
colon carcinomaAkt1 , Braf , Ctnnb1 , Ep300 , Nras , Pik3ca , Tp53
Colonic NeoplasmsBcl2 , Braf , Ccnd1 , Ccne1 , Cdkn1a , Ctnnb1 , Egfr , Erbb2 , Gsk3b , Kras , Lef1 , Nfkb1 , Pdgfrb , Pik3r1 , Pik3r2 , Rela , Tcf7l2 , Tp53
colorectal adenocarcinomaBraf , Gsk3b , Mapk1 , Mapk3 , Raf1 , Tp53
colorectal adenomaGstp1 , Raf1
colorectal cancerAkt1 , Akt2 , Braf , Casp9 , Ctnnb1 , Egfr , Ep300 , Nras , Pik3ca , Pik3cd , Pik3r1 , Tcf3 , Tcf7l2 , Tp53
Colorectal NeoplasmsAkt1 , Akt2 , Bcl2 , Braf , Ccnd1 , Crebbp , Ctnnb1 , Egfr , Ep300 , Erbb2 , Gstp1 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3r1 , Pik3r3 , Pten , Raf1 , Tcf7l2 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
common variable immunodeficiencyNfkb1
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Mtor , Pik3ca
conduct disorderAr
Congenital CholesteatomaCdkn1a
congenital diaphragmatic herniaEp300 , Igf1 , Igf1r , Pdgfra
Congenital Disorder of Glycosylation Type 1AIgf1
congenital dyserythropoietic anemiaTp53
Congenital Foot DeformitiesFgfr1
Congenital Generalized FibromatosisPdgfrb
congenital hypoplastic anemiaTp53
congenital hypothyroidismIgf1
Congenital Limb DeformitiesChuk , Fgfr2
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureBcl2 , Ep300 , Erbb2 , Foxo1 , Gsk3b , Igf1 , Ins2 , Mtor , Pdgfra , Pdpk1 , Tp53
conjunctivochalasisGstp1
contact dermatitisBcl2 , Gstp1 , Hsp90aa1
corneal diseaseIgf1
coronary artery diseaseAkt1 , Ar , Pdgfd
Coronary DiseaseIgf1 , Tcf7l2
coronary restenosisMapk1 , Tp53
coronary stenosisIgf1 , Igf1r
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2
CoughGstp1
Cowden syndromeEgfr , Pik3ca , Pten
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca , Pten
Craniofacial AbnormalitiesCtnnb1 , Egfr , Ep300 , Fgfr1 , Fgfr2 , Pdgfra , Pten , Tp53
craniopharyngiomaBraf , Ctnnb1 , Pdgfra
craniosynostosisFgfr1 , Fgfr2
Craniosynostosis Syndrome, Autosomal RecessiveFgfr2
crescentic glomerulonephritisMtor
Crohn's diseaseIgf1 , Tcf7
Crouzon syndromeFgfr2
cryptorchidismAr , Igf1r , Nfkbia , Rela
Currarino TriadPik3ca
cutaneous T cell lymphomaBraf , Tp53
cystic fibrosisGstp1 , Igf1
cystic kidney diseaseIns2
cystitisRela
DeafnessIgf1
degenerative disc diseaseGsk3b
Delayed PubertyFgfr1
dementiaBcl2 , E2f1 , Egfr , Igf1r
demyelinating diseaseFgfr1 , Igf1 , Mapk1 , Tp53
Denys-Drash syndromeAr
dermatitisEgf , Egfr , Ikbkb
dermatofibrosarcoma protuberansPdgfb
developmental coordination disorderFgfr2 , Pten
Developmental DisabilitiesAkt3 , Braf , Creb3l1 , Crebbp , Ep300 , Mapk3 , Pik3r2 , Pten
Diabetes ComplicationsCasp9
diabetes mellitusIgf1 , Igf1r , Ins1 , Ins2 , Pten , Srd5a2 , Tcf7l2
Diabetes Mellitus, Experimental Akt1 , Ar , Bad , Bcl2 , Casp9 , Cdkn1a , Egfr , Ep300 , Hras , Hsp90aa1 , Igf1 , Igf1r , Ikbkb , Mapk1 , Mapk3 , Mdm2 , Mtor , Nfkbia , Pdgfb , Pdgfrb , Pik3r1 , Rela , Tp53
Diabetes Mellitus, New-Onset after TransplantationMtor
diabetic angiopathyRela
Diabetic CardiomyopathiesBad , Bcl2 , Casp9 , Ctnnb1 , Erbb2 , Igf1 , Ins2 , Mapk1 , Mapk3
Diabetic CystopathyBad
diabetic encephalopathyGsk3b
Diabetic FootIgf1
diabetic ketoacidosisIns2
Diabetic NephropathiesCasp9 , Ccne1 , Cdkn1a , Cdkn1b , Creb1 , Egf , Ep300 , Gsk3b , Igf1 , Igf1r , Ins2 , Mapk1 , Mtor , Pdgfa , Pdgfb , Pdgfrb , Pten , Rela , Tcf7l2 , Tp53
diabetic neuropathyBad , Igf1
diabetic retinopathyCasp9 , Egfr , Ep300 , Hras , Igf1 , Igf1r , Ins2
Diamond-Blackfan anemiaTp53
Diamond-Blackfan Anemia 6Tp53
Diaphragmatic HerniaIgf1
diffuse large B-cell lymphomaBcl2 , Gstp1 , Nfkbia , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Tp53
dilated cardiomyopathyBcl2 , Casp9 , Creb1 , Ctnnb1 , Egfr , Erbb2 , Igf1 , Kras , Lef1 , Raf1 , Tp53
dilated cardiomyopathy 1NNRaf1
diseaseCtnnb1
disease of cellular proliferationBraf , Ctnnb1 , Erbb2 , Fgfr1 , Hras , Kras , Map2k1 , Mdm2 , Nras , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53
disease of metabolismIns2
Disease ProgressionBcl2 , Ccne1 , Ctnnb1 , Egf , Egfr , Erbb2 , Gstp1 , Hras , Pik3ca , Pten
drug allergyGstp1
Drug-Induced DyskinesiaGsk3b , Mtor , Rela
Drug-Induced LeukopeniaGstp1
Drug-induced NeutropeniaGstp1 , Mdm2 , Tp53
Drug-Related Side Effects and Adverse ReactionsIgf1 , Tp53
Ductal CarcinomaHsp90aa1
ductal carcinoma in situAr , Bcl2 , Ccnd1 , Cdkn1a , Erbb2 , Rb1 , Rela , Tp53
duodenal atresiaFgfr2
DwarfismEp300 , Igf1 , Tp53
dysembryoplastic neuroepithelial tumorBraf
dysgerminomaFgfr2
dyskeratosis congenitaTp53
dystoniaIns2
Ectodermal Dysplasia, Anhidrotic, with T-Cell Immunodeficiency, Autosomal DominantNfkbia
EdemaCasp9 , Ins2
embryonal carcinomaRb1
EmphysemaTp53
encephalitisNfkbia , Rela
Encephalocraniocutaneous LipomatosisFgfr1
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg
end stage renal failureBcl2 , Igf1 , Mtor , Nfkb1 , Rela
Endocrine Bone DiseasesPdgfa
endodermal sinus tumorCtnnb1
endometrial adenocarcinomaKras , Mapk1 , Mapk3 , Pik3r1 , Tp53
endometrial cancerAkt2 , Ar , Bad , Egf , Fgfr2 , Kras , Pik3cb , Pik3cd , Pik3r1 , Pten , Tp53
endometrial carcinomaBraf , Fgfr2 , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk3 , Ncor2 , Pik3ca , Pik3r1 , Pten , Tp53
endometrial hyperplasiaKras , Pten
Endometrial NeoplasmsBcl2 , Ccnd1 , Cdk2 , Cdkn1a , Cdkn1b , Ctnnb1 , Egf , Ep300 , Erbb2 , Fgfr2 , Gsk3b , Igf1r , Kras , Mapk3 , Pik3ca , Pik3cb , Pten , Rb1 , Srd5a2 , Tp53
Endometrioid CarcinomasAkt1 , Ccne1 , Cdk2 , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Fgfr2 , Kras , Mapk1 , Mapk3 , Pdgfra , Pdgfrb , Pik3r2 , Pten
endometriosisAr , Bcl2 , Ccne2 , Egfr , Fgfr2 , Igf1 , Kras , Nfkbia , Srd5a2
endometritisCasp9
EndotoxemiaBcl2 , Casp9 , Ep300 , Igf1
EosinophiliaPdgfra
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1 , Rela
esophageal cancerTp53
esophageal carcinomaCtnnb1 , Egfr , Ep300 , Erbb2 , Fgfr2 , Hras , Kras , Pik3ca , Tp53
Esophageal NeoplasmsBcl2 , Ccnd1 , Cdkn1a , Egfr , Erbb2 , Tp53
esophagus adenocarcinomaPik3ca , Tp53
esophagus squamous cell carcinomaCtnnb1 , Egfr
essential thrombocythemiaPdgfa , Pdgfb
essential tremorGstp1
Experimental Allergic AsthmaBcl2
Experimental ArthritisAkt1 , Bcl2 , Egfr , Fgfr1 , Gsk3b , Igf1 , Ikbkb , Ikbkg , Mtor , Nras , Pik3cd
Experimental Autoimmune EncephalomyelitisCasp9 , Igf1 , Pdgfb , Pdgfra , Pdgfrb
Experimental Autoimmune MyocarditisCasp9
Experimental ColitisMapk1 , Mapk3 , Nfkbia , Pdgfra , Pdgfrb
Experimental LeukemiaFgfr1 , Nras
Experimental Liver CirrhosisBcl2 , Cdk2 , Cdkn1a , Egf , Igf1 , Igf1r , Ins2 , Mapk1 , Mapk3 , Mtor , Ncor2 , Nfkbia , Pdgfa , Pdgfra , Pdgfrb , Rela
Experimental Liver NeoplasmsBcl2 , Ccnd1 , Cdkn1a , Ctnnb1 , Gstp1 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Rb1 , Tgfa , Tp53
Experimental MelanomaIkbkb
Experimental NeoplasmsBraf , Ccnd1 , Erbb2 , Hras , Kras , Nras , Rb1 , Rela , Tp53
Experimental PancreatitisIkbkg
Experimental SarcomaKras , Nras
Experimental SeizuresGstp1
extrahepatic cholestasisMapk1 , Mapk3 , Pdgfrb , Rela
Exudative Vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Fabry diseaseAr
Facial AsymmetryPik3ca
facioscapulohumeral muscular dystrophyCdkn1a
Fallopian Tube NeoplasmsCdkn1b
familial adenomatous polyposisAkt1 , Egfr
familial hypertrophic cardiomyopathyKras , Raf1 , Sos1
familial Mediterranean feverIgf1
familial medullary thyroid carcinomaInsrr
familial meningiomaPdgfb , Pten
familial partial lipodystrophyAkt2
Familial Prostate CancerAr , Bcl2 , Cdkn1b , Map2k1 , Tcf7l2
fatty liver diseaseAtf4 , Creb1 , Ikbkg , Ins2 , Nfkb1 , Pten , Rela
favismIkbkg
Female InfertilityAr , Hsp90ab1 , Mapk1 , Mapk3 , Tp53
Female Urogenital DiseasesIgf1
Femoral FracturesFgfr1 , Lef1
fetal alcohol spectrum disorderIgf1 , Igf1r , Pten
Fetal DeathPdgfra
Fetal DiseasesChuk
Fetal Growth RetardationBcl2 , Igf1 , Igf1r , Mdm2 , Pdgfa , Pdgfb
Fetal MacrosomiaIgf1 , Pten
fibrillary astrocytomaKras
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Cdkn1b , Pdgfb , Pdgfd
Focal Cortical Dysplasia of TaylorMtor
focal segmental glomerulosclerosisCasp9
folic acid deficiency anemiaIgf1
follicular lymphomaBcl2 , Crebbp
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras , Pten
Frontotemporal Lobar DegenerationHsp90aa1
Fuchs' endothelial dystrophyCdkn1a
Funnel ChestTp53
gallbladder cancerEgf
gallbladder carcinomaErbb2 , Pik3ca , Tgfa , Tp53
Gallbladder NeoplasmsBcl2 , Egfr , Erbb2 , Gstp1 , Kras , Tp53
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Crebbp , Ctnnb1 , Erbb2 , Fgfr1 , Fgfr2 , Hras , Kras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Pten , Raf1 , Tp53
gastric ulcerBad , Bcl2 , Egf , Mapk1 , Mapk3
gastrinomaIgf1r
gastritisNfkbia
gastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten
gastrointestinal stromal tumorBraf , Kras , Pdgfra , Rb1
gastroschisisIgf1r
Gaucher's diseaseTp53
Gaucher's disease type ITp53
genetic diseaseAkt2 , Akt3 , Ar , Braf , Crebbp , Ctnnb1 , Ep300 , Erbb2 , Fgfr2 , Hras , Igf1r , Ikbkg , Kras , Map2k1 , Mapk1 , Mtor , Pdgfrb , Pik3ca , Pik3r1 , Pik3r2 , Pten , Raf1 , Sos1
Genetic Predisposition to DiseaseEgf , Tgfa
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsCcne1 , Erbb2 , Pdgfra
germinomaBraf
gestational diabetesAr , Igf1r , Ins2 , Tcf7l2
Giant Pigmented Hairy NevusHras , Nras
gingival fibromatosisSos1
Gingival HyperplasiaPdgfb
glaucomaBad , Bcl2 , Cdkn1b , Crebbp
glioblastoma multiformeAkt1 , Akt3 , Braf , Crebbp , E2f1 , Egf , Egfr , Erbb2 , Fgfr1 , Hras , Kras , Map2k2 , Mdm2 , Mtor , Nras , Pdgfb , Pdgfrb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pten , Rb1 , Tp53
glioblastoma proneural subtypeRb1
GliosisMapk1 , Mapk3
glomerulonephritisEp300 , Mapk1 , Pdgfb , Pdgfd
glucose intoleranceIns2
glucosephosphate dehydrogenase deficiencyIkbkg
grade III astrocytomaKras , Tp53
Graft vs Host DiseasePdgfb , Tp53
granulomatosis with polyangiitisIgf1
granulosa cell tumorCtnnb1
Graves OphthalmopathyIgf1
Graves' diseaseGstp1 , Igf1 , Igf1r , Tp53
Growth DisordersIgf1 , Igf1r , Pik3ca
growth hormone secreting pituitary adenomaCdkn1a
Gynecomastia, FamilialAr
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsBcl2 , Egfr , Fgfr2 , Mapk1 , Mapk3 , Pik3ca , Tgfa , Tp53
head and neck squamous cell carcinomaAkt1 , Braf , Ccnd1 , Crebbp , Ctnnb1 , Egfr , Ep300 , Erbb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Pten , Tp53
Head Injuries, ClosedIgf1
Head Injuries, PenetratingFgfr1 , Pdgfb
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a , Igf1
Hearing Loss, SuddenIgf1
heart diseaseCasp9 , Ep300 , Gsk3b
heart valve diseaseFgfr1
Heat StrokeNfkb1 , Rela
Helicobacter InfectionsCdkn1b
HELLP syndromeErbb2
hemangiomaPten
hematopoietic system diseaseGstp1
HemimegalencephalyMtor , Pik3ca
Henoch-Schoenlein purpuraIgf1
Hepatic InsufficiencyRela
hepatitisIns2
hepatoblastomaCtnnb1 , Tgfa , Tp53
Hepatoblastoma Caused By Somatic MutationCtnnb1
hepatocellular adenomaCdkn1b , Ctnnb1 , Hras , Kras , Pten
hepatocellular carcinomaAkt1 , Akt2 , Ar , Braf , Casp9 , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Crebbp , Ctnnb1 , E2f1 , Egf , Egfr , Ep300 , Fgfr1 , Gstp1 , Hras , Igf1 , Igf1r , Ins1 , Kras , Mdm2 , Mtor , Nfkbia , Nras , Pdgfb , Pik3ca , Pten , Rb1 , Tgfa , Tp53
HepatomegalyPten , Rela
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeTp53
Hereditary Desmoid DiseaseCtnnb1
Hereditary Neoplastic SyndromesCdkn1b , Egfr , Pdgfra , Pdgfrb , Pik3ca , Pten , Rb1 , Tcf7 , Tp53
Hereditary PancreatitisCasp9
hereditary renal cell carcinomaEgf
hereditary sensory neuropathy type 4Insrr
hereditary spastic paraplegia 11Tp53
Hirschsprung Disease 1Crebbp
Hirschsprung's diseaseErbb2
Histiocytoma, Angiomatoid FibrousCreb1
Hodgkin's lymphomaGstp1 , Nfkbia
holoprosencephalyCreb1 , Fgfr1
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/PalateFgfr1
human immunodeficiency virus infectious diseaseCdkn1a , Hsp90aa1 , Hsp90ab1 , Mdm2
Huntington's diseaseBcl2 , Casp9 , Creb1 , Crebbp , E2f1 , Egfr , Ep300 , Igf1 , Igf1r , Nfkb1
Hydatidiform MolePdgfrb
HyperalgesiaEp300 , Igf1 , Mapk1 , Mapk3 , Mtor , Raf1
HypercholesterolemiaCasp9
hypereosinophilic syndromePdgfra
hyperglycemiaIns2
hyperinsulinismIns2 , Pten
HyperkalemiaIns2
HyperoxaluriaNfkb1
HyperoxiaCdkn1a , Igf1 , Pdgfra , Pdgfrb
Hyperoxic Lung InjuryPdgfb
HyperparathyroidismCcnd1
HyperphagiaIgf1 , Igf1r
HyperplasiaAkt1 , Ccnd1 , Cdkn1a , Egfr , Ikbkb , Pik3ca , Tcf7l2
HyperproinsulinemiaIns1 , Ins2
hyperprolactinemiaSrd5a2
HypertelorismFgfr2
hypertensionAkt1 , Akt2 , Ar , Bad , Bcl2 , Casp9 , Ccne1 , Egfr , Ep300 , Gsk3b , Gstp1 , Igf1 , Igf1r , Ikbkb , Ins2 , Kras , Mtor , Nfkbia , Pdgfb , Pdgfra , Pdgfrb , Pik3r1 , Pten , Rela , Tp53
hyperthyroidismIgf1r
HypertriglyceridemiaIns2 , Mtor
hypertrophic cardiomyopathyBcl2 , Ctnnb1 , Igf1 , Igf1r , Ins2 , Raf1 , Tp53
hypertrophic cardiomyopathy 4Braf
HypertrophyCdkn1a , Mapk1 , Mapk3 , Pten
hyperuricemiaIns2
Hypoglossal Nerve InjuriesFgfr1
hypoglycemiaAkt2 , Creb1 , Ins2 , Pik3r1
hypogonadismAr , Fgfr1 , Nras
hypogonadotropic hypogonadismFgfr1 , Nras
hypogonadotropic hypogonadism 2 with or without anosmiaFgfr1
hypogonadotropic hypogonadism 7 with or without anosmiaFgfr1 , Nras
Hypogonadotropic Hypogonadism and Anosmia, Autosomal DominantFgfr1
hypohidrotic ectodermal dysplasiaIkbkg
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypokalemiaIns2
hypomelanosis of ItoIkbkg
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypospadiasAr , Fgfr2 , Srd5a2
Hypospadias 1, X-LinkedAr
HypotensionIns2
HypothermiaBcl2 , Mdm2
hypothyroidismBad , Igf1
hypotrichosis 8Rb1
HypovolemiaCdkn1a
HypoxiaAtf4
Hypoxia-Ischemia, BrainBcl2 , Casp9 , Igf1 , Pdgfb
ichthyosisMdm2
Idiopathic Basal Ganglia Calcification 1Pdgfb , Pdgfrb
Idiopathic Basal Ganglia Calcification 4Pdgfrb
Idiopathic Basal Ganglia Calcification 5Pdgfb
idiopathic interstitial pneumoniaMtor
IgA glomerulonephritisIgf1r
Immediate HypersensitivityEgfr
Immunodeficiency 14Pik3cd
IMMUNODEFICIENCY 15AIkbkb
Immunodeficiency 15BIkbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
imperforate anusCtnnb1
impotenceAkt1 , Bad , Bcl2 , Ccnd1
in situ carcinomaAkt1 , Ctnnb1 , Pdgfra , Pten , Rb1
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaEgf
infantile myofibromatosisPdgfrb
InflammationAkt1 , Chuk , Egfr , Mtor , Pdgfb , Tgfa
inflammatory bowel diseaseIkbkb , Pdgfb
Insulin ResistanceAkt2 , Ar , Bad , Egfr , Foxo1 , Ikbkb , Ins2 , Mapk3 , Pik3r1 , Pten , Rb1 , Rela , Tcf7l2
Insulin-Like Growth Factor I DeficiencyIgf1
Insulin-Like Growth Factor I, Resistance ToIgf1r
insulinomaIns2 , Tgfa
intellectual disabilityCtnnb1 , Ep300 , Fgfr2 , Kras , Pten , Rb1
intermediate coronary syndromeAkt1
intermittent claudicationBad , Mdm2
interstitial cystitisMtor
Intervertebral Disc DisplacementAkt1 , Igf1
intestinal atresiaFgfr2
intestinal diseaseBcl2
Intestinal NeoplasmsBcl2 , Cdkn1a , Cdkn1b , Ctnnb1 , Gsk3b
Intestinal PolypsCcnd1
intestinal pseudo-obstructionPten , Rb1
Intestinal Reperfusion InjuryCasp9
Intimal HyperplasiaCdk2 , Mdm2 , Pdgfd , Pdgfrb
intracranial aneurysmBcl2
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Ar , Atf4 , Erbb2
invasive lobular carcinomaCcnd1 , Ctnnb1 , Erbb2
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
inverted papillomaCdkn1a
irritable bowel syndromeIkbkg
ischemiaAkt2 , Raf1 , Tp53
isolated cleft palatePdgfra
Jackson-Weiss SyndromeFgfr1 , Fgfr2
juvenile myelomonocytic leukemiaKras , Nras
juvenile polyposis syndromePten
juvenile rheumatoid arthritisEgf , Igf1r , Kras , Mapk1 , Tcf7l2
Kallmann syndromeFgfr1
Kaposi's sarcomaTp53
Kashin-Beck DiseaseBcl2
Kennedy's diseaseAr
keratoconusFoxo1
keratosisTp53
kidney angiomyolipomaMtor
Kidney CalculiGstp1
kidney diseaseCasp9 , Cdkn1a , Egf , Gstp1 , Igf1 , Mapk1
kidney failureIns2
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn1b , Erbb2 , Kras , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryBcl2 , Ep300 , Igf1r , Ikbkb , Pdgfb , Pdgfra , Pdgfrb
Klinefelter's syndromeFgfr1 , Nras
Knee OsteoarthritisAr , Bcl2 , Ctnnb1 , Hsp90aa1 , Igf1 , Igf1r , Tgfa
KOSAKI OVERGROWTH SYNDROMEPdgfrb
Kuhnt-Junius degenerationGstp1 , Igf1 , Igf1r , Pdgfb , Pdgfrb
L-2-hydroxyglutaric aciduriaSos2
LADD syndromeFgfr2
Langerhans-cell histiocytosisBraf
Language Development DisordersPten
Laron syndromeIgf1
Laryngeal NeoplasmsEgfr , Gstp1
laryngeal squamous cell carcinomaCdkn1a
late onset Parkinson's diseaseGstp1
Lead Poisoning, Nervous SystemEp300
learning disabilityBcl2 , Ikbkg
Leber hereditary optic neuropathyTp53
Left Ventricular HypertrophyCdkn1b , Egfr , Mtor , Pten , Rela
leiomyomaAr , Bcl2 , Pdgfa , Pdgfb , Pten
LEOPARD syndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaAr , Bad , Ccnd1 , Nras , Pdgfra , Pten , Tp53
LeukocytosisKras , Nras
LeukoencephalopathiesCdkn1b
Lewy body dementiaIgf1r , Ins2
Leydig cell tumorCdkn1b , Pdgfa , Pdgfb , Pdgfra , Pdgfrb
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 1Tp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Limb IschemiaFgfr1
Lip NeoplasmsCdkn1a , Tp53
lipoid nephrosisCdkn1a
lipomaPten
lipomatosisPten
Lipoyltransferase 1 DeficiencyTp53
liver benign neoplasmBraf , Ccnd1 , Cdkn1a , Cdkn1b , Ctnnb1 , Hras , Kras , Raf1 , Tgfa , Tp53
liver cancerAkt1 , Crebbp , Ctnnb1 , Hras , Kras , Nras , Pik3ca , Tp53
liver cirrhosisCasp9 , Ctnnb1 , Fgfr2 , Pdgfb , Pdgfd
liver diseaseGstp1 , Ins2 , Mdm2 , Nfkb1
Liver InjuryPdgfb
Liver Reperfusion InjuryBad , Bcl2 , Casp9 , Gsk3b , Ikbkg
localized sclerodermaCdkn1a
long QT syndromeE2f1 , Pten
low tension glaucomaTp53
Lubs SyndromeAr
lung adenocarcinomaAkt1 , Braf , Ccnd1 , Ctnnb1 , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fgfr2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1 , Tp53
lung cancerBraf , Egfr , Erbb2 , Kras , Nfkbia , Pik3ca
lung carcinomaCtnnb1
lung diseaseEgfr , Gstp1 , Igf1r , Pdgfa , Pdgfra
Lung InjuryMtor , Nfkbia , Pdgfd , Tgfa
Lung NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn1a , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Fgfr1 , Fgfr2 , Gstp1 , Hras , Ikbkg , Kras , Mapk1 , Mapk3 , Mtor , Pdgfrb , Pik3ca , Pten , Raf1 , Tp53
Lung Reperfusion InjuryBcl2
lung small cell carcinomaAkt1 , Bcl2 , Ccnd1 , Cdkn1b , Crebbp , E2f1 , Egfr , Ep300 , Fgfr1 , Mtor , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53
lung squamous cell carcinomaAkt1 , Braf , Ccnd1 , Crebbp , Ctnnb1 , E2f1 , E2f3 , Egfr , Ep300 , Fgfr2 , Hras , Kras , Pik3ca , Pten , Tp53
lupus nephritisEgf , Mtor
LymphangiectasisRaf1
Lymphatic MetastasisBcl2 , Casp9 , Ccne1 , Cdkn1a , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Fgfr2 , Pdgfa , Pdgfb , Pdpk1 , Pik3ca , Pik3cb , Pten , Rela , Tp53
lymphocytic leukemiaGstp1
lymphomaKras , Nras , Pten , Rela , Tp53
MacrocephalyAkt3 , Pten
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3 , Pten
macular degenerationBad , Cdkn1a , Cdkn1b
Male Breast NeoplasmsAr
male infertilityAr , Bcl2 , Mdm2 , Tp53
male reproductive system diseaseAr
malignant gliomaAkt2 , Bad , Braf , Ccnd1 , Cdkn1a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fgfr1 , Gstp1 , Hras , Igf1 , Igf1r , Kras , Map2k1 , Mapk3 , Mtor , Pdgfa , Pdgfb , Pik3ca , Pik3r3 , Pten , Raf1 , Tp53
malignant mesotheliomaBcl2 , Ccne2 , Cdkn1a , Ctnnb1 , Egfr , Raf1 , Tp53
MalocclusionIgf1 , Igf1r
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Ar , Bad , Bcl2 , Casp9 , Ccnd1 , Ccne1 , Cdk2 , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Gsk3b , Hras , Igf1 , Mapk1 , Mapk3 , Mtor , Pdgfa , Pik3r1 , Pten , Rb1 , Rela , Tgfa , Tp53
mammary Paget's diseaseErbb2
Mandibular NeoplasmsBraf , Ctnnb1
mantle cell lymphomaCcnd1 , Ctnnb1 , Gsk3b , Mtor , Pik3cd
marginal zone B-cell lymphomaTp53
mastoiditisRela
maturity-onset diabetes of the youngIns1 , Ins2
maturity-onset diabetes of the young type 10Ins1 , Ins2
maxillary sinus squamous cell carcinomaCdkn1a
median neuropathyErbb2
medulloblastomaCcnd1 , Ccne1 , Crebbp , Ctnnb1 , Ep300 , Erbb2 , Fgfr1 , Nras , Pdgfra , Pik3ca , Rb1 , Tp53
Megakaryoblastic Leukemia of Down SyndromeNras , Tp53
megakaryocytic leukemiaPten , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Bcl2 , Braf , Cdk2 , Cdkn1a , Crebbp , Ctnnb1 , E2f1 , Ep300 , Erbb2 , Gstp1 , Hras , Kras , Map2k1 , Map2k2 , Mdm2 , Mtor , Nfkb1 , Nfkbia , Nras , Pdgfra , Pik3ca , Pik3r1 , Pten , Raf1 , Srd5a2 , Tp53
membranoproliferative glomerulonephritisCdk2 , Cdkn1b , Ep300
membranous glomerulonephritisCdkn1b
Memory DisordersBcl2 , Creb1 , Ins2
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pdgfb , Pten
meningitisGstp1
Menke-Hennekam Syndrome 1Crebbp
Menke-Hennekam Syndrome 2 Ep300
mental depressionFgfr1 , Gsk3b
mesangial proliferative glomerulonephritisFgfr1 , Pdgfd
mesenchymal chondrosarcomaBcl2 , Pdgfra
MesotheliomaCdkn1b , Egfr , Mtor , Pdgfa , Pdgfc , Tp53
Metabolic Bone DiseasesIgf1 , Igf1r
Metabolic SyndromeIns2
MetaplasiaBcl2 , Egf
microcephalyEp300 , Igf1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveIns2
Microsatellite InstabilityBraf
middle cerebral artery infarctionBad , Bcl2 , Casp9 , Gsk3b , Igf1 , Ikbkb , Mapk1 , Mapk3 , Mtor , Nfkbia , Pdgfra , Pdgfrb
migraineMap2k2
Mitochondrial Complex I Deficiency, Nuclear Type 20Pik3ca
morphine dependenceBcl2 , Creb1
mouth diseaseFgfr1
Mouth NeoplasmsErbb2 , Hras , Kras , Nras , Pik3ca , Pten , Tp53
movement diseaseGstp1
MPTP PoisoningIns2
mucositisTgfa
Mullerian AplasiaAr
Multi-Infarct DementiaBcl2
Multicystic Dysplastic KidneyPdgfa
Multiple AbnormalitiesChuk , Crebbp , Ctnnb1 , Ep300 , Fgfr2 , Gsk3b , Kras , Mapk1 , Pdgfrb , Pik3r2 , Pten
Multiple Endocrine NeoplasiaCdkn1b
multiple endocrine neoplasia type 4Cdkn1b
Multiple Hamartoma SyndromeFgfr2 , Pik3ca , Pten
multiple myelomaBcl2 , Braf , Ccnd1 , Gstp1 , Hras , Kras , Nfkbia , Nras , Pik3ca , Tp53
Multiple Organ FailureMapk1
multiple sclerosisGstp1 , Hsp90ab1
Muscle SpasticityCrebbp
muscular atrophyAkt1 , Chuk , Ctnnb1 , Gsk3b , Hsp90ab1 , Igf1 , Ikbkb , Mtor
muscular diseaseIns2
muscular dystrophyPten
Muscular Dystrophy, AnimalMtor
myelodysplastic syndromeCdkn1b , Crebbp , Gstp1 , Hras , Kras , Mdm2 , Nras , Tp53
myelofibrosisNcor2 , Tp53
myeloid leukemiaFgfr1 , Gstp1 , Pdgfra
myeloid neoplasmFgfr1 , Kras , Nras
myeloid sarcomaKras , Pdgfra
Myeloproliferative Disorder, Chronic, with EosinophiliaPdgfrb
myeloproliferative neoplasmPdgfrb
myocardial infarctionAkt1 , Bcl2 , Cdkn1b , Creb1 , Fgfr1 , Gsk3b , Igf1 , Igf1r , Mapk1 , Mtor , Nfkbia , Pdgfd , Tp53
Myocardial IschemiaBcl2 , Ccnd1 , Erbb2 , Gstp1 , Igf1 , Nfkbia
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bcl2 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mdm2 , Nfkbia , Pten , Rela , Tp53
myopiaIgf1
nasal cavity cancerTp53
Nasal PolypsIgf1
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Fgfr2 , Hras , Nras , Pik3ca , Tp53
nasopharynx carcinomaBcl2 , Tp53
NecrosisAtf4 , Bcl2 , Gstp1
Nematode InfectionsPik3r1
NeointimaFgfr1 , Igf1 , Pdgfb , Pdgfra , Pdgfrb
neonatal diabetes mellitusIns1 , Ins2
Neonatal HyperbilirubinemiaIkbkb
Neonatal Inflammatory Skin and Bowel Disease 2Egfr
Neoplasm InvasivenessCtnnb1 , Egf , Egfr , Hras , Igf1 , Lef1 , Mapk1 , Mapk3 , Pten , Rela
Neoplasm MetastasisAkt2 , Bcl2 , Braf , Ccnd1 , Ccne1 , Cdkn1a , Chuk , Ctnnb1 , Egf , Egfr , Erbb2 , Fgfr1 , Hsp90aa1 , Igf1 , Igf1r , Kras , Lef1 , Mapk1 , Mapk3 , Mtor , Nfkb1 , Nfkbia , Pdgfb , Pdgfrb , Pik3ca , Pik3r3 , Pten , Rb1 , Tcf3 , Tp53
Neoplasm Recurrence, LocalAr , Creb3l4 , Egfr , Erbb2
Neoplastic ProcessesHras
nephritisMtor
nephroblastomaCdkn1b , Ctnnb1 , Erbb2 , Igf1r , Tp53
nephronophthisis-like nephropathy 1Ep300
Nerve DegenerationBcl2 , Ctnnb1 , Igf1 , Mapk1 , Mapk3 , Tgfa
Nerve Sheath NeoplasmsPten , Tp53
nervous system diseaseCasp9 , Tp53
neural tube defectIns2
neuroblastomaFgfr1 , Hras , Igf1r , Kras , Nras , Pik3ca , Tp53
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersCtnnb1 , Pten , Tcf7l2
neuroendocrine tumorBraf , Cdkn1b
neurofibrosarcomaNras
neuronal ceroid lipofuscinosis 6Gsk3b , Mapk1 , Mapk3
NevusBraf
Nevus, PigmentedHras , Nras
No-Reflow PhenomenonCtnnb1
non-Hodgkin lymphomaBcl2 , Braf , Ccnd1 , Map2k1 , Nras , Pik3ca , Tp53
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ccne1 , Cdkn1b , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Fgfr1 , Gstp1 , Hras , Kras , Map2k1 , Mdm2 , Nfkb1 , Nras , Pdpk1 , Pik3ca , Pten , Raf1 , Rb1 , Rela , Tgfa , Tp53
nonalcoholic fatty liver diseaseGstp1 , Igf1 , Igf1r , Ikbkg
Nonseminomatous Germ Cell TumorBraf
nonsyndromic deafnessTgfa
Nonsyndromic TrigonocephalyFgfr1
Noonan Like SyndromeSos1
Noonan syndromeBraf , Hras , Igf1 , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras , Raf1
Noonan syndrome 3Hras , Kras , Raf1 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
NSAID-EnteropathyCasp9
obesityAkt1 , Akt2 , Ar , Bad , Bcl2 , Cdkn1b , Egfr , Ep300 , Fgfr1 , Igf1r , Ikbkb , Ins2 , Mapk1 , Mapk3 , Mtor , Pik3r1 , Rb1 , Rela
obsessive-compulsive disorderHras
obstructive sleep apneaRela
ocular hypertensionCdkn1a
Odontogenic MyxomaTp53
oligodendrogliomaEgf , Rb1
oligohydramniosPdgfa , Pdgfb , Pdgfra , Pdgfrb
oligomeganephroniaBcl2
oppositional defiant disorderAr
Optic Nerve InjuriesBcl2 , Cdk2 , Ep300 , Igf1r , Pdgfb
Oral Lichen PlanusCdkn1a , Tp53
oral mucosa leukoplakiaBcl2 , Cdkn1a , Tp53
oral squamous cell carcinomaCdkn1a , Gstp1
oral submucous fibrosisTp53
Oropharyngeal NeoplasmsTp53
osteoarthritisBad , Bcl2 , Casp9 , Fgfr1 , Igf1 , Igf1r , Ins2 , Mtor , Ncor2
Osteoarthritis, ExperimentalFgfr1 , Mapk3
osteochondrodysplasiaBcl2 , Pten
osteogenesis imperfectaCreb3l1
osteogenesis imperfecta type 16Creb3l1
Osteoglophonic DwarfismFgfr1
OsteophytesIgf1
osteoporosisAr , Bcl2 , Gstp1 , Igf1 , Igf1r
Osteoporotic FracturesAr , Igf1
osteosarcomaAkt1 , Egfr , Gstp1 , Rb1 , Tp53
otitis mediaFgfr1 , Rela
ovarian cancerAkt1 , Ctnnb1 , Egf , Erbb2 , Gstp1 , Kras , Lef1 , Pik3ca , Tp53
ovarian carcinomaAkt2 , Ccnd1 , Ccne1 , Map2k1
ovarian cystNfkb1
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2 , Braf , Ccne1 , Cdk2 , Cdkn1a , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Fgfr2 , Gsk3b , Hras , Kras , Map2k2 , Mapk1 , Mapk3 , Mtor , Pdgfra , Pdgfrb , Pik3ca , Pik3r1 , Pten , Rb1 , Rela , Tp53
ovarian serous cystadenocarcinomaBraf , Erbb2 , Hras , Nras , Pik3ca , Tp53
ovarian small cell carcinomaTp53
ovary adenocarcinomaErbb2
ovary epithelial cancerPik3ca
ovary serous adenocarcinomaTp53
Oxygen-Induced RetinopathyIgf1
PainAkt1
Painful NeuropathyEp300
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaAkt3 , Ccnd1 , Ctnnb1 , E2f1 , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Nfkb1 , Pik3ca , Raf1 , Tp53
pancreatic cancerAkt1 , Akt2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , E2f1 , Egf , Egfr , Gstp1 , Igf1 , Igf1r , Ins2 , Kras , Mtor , Nfkbia , Pdgfra , Pten , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
pancreatic carcinomaCdkn1a , Kras , Mtor , Raf1 , Tp53
pancreatic ductal adenocarcinomaCcnd1 , E2f1 , Ikbkb , Pik3r2
pancreatic ductal carcinomaCcnd1 , Cdkn1a , Egf , Gstp1 , Igf1 , Igf1r , Ins2 , Kras , Mapk3 , Mdm2
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1 , Ikbkb
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisEgf , Hsp90ab1 , Ikbkb , Ins2 , Map2k1 , Mdm2 , Pdgfa , Pdgfb
Pancreatitis, Experimental, Acute Cdkn1a , Kras
pancytopeniaTp53
panic disorderIns2
papillary renal cell carcinomaBraf , Ctnnb1 , Erbb2 , Hras , Mtor , Nras , Pik3ca , Pten , Tp53
papillary thyroid carcinomaBraf , Ccnd1 , Ctnnb1 , Lef1
papillomaCcnd1 , Cdkn1a , Egfr , Erbb2 , Hras , Tgfa
ParalysisIns2
paranasal sinus neoplasmTp53
paraplegiaAkt1
Parasitic Liver DiseasesKras , Tp53
Parathyroid NeoplasmsCtnnb1
ParesthesiaIns2
Parkinson's diseaseAkt1 , Casp9 , Egf , Egfr , Erbb2 , Gsk3b , Gstp1 , Igf1r , Ins2
Parkinsonian DisordersBad , Casp9 , Egfr , Mtor , Pdgfrb , Rela
Pdgfra-Associated Chronic Eosinophilic LeukemiaPdgfra
Pediatric Adrenocortical CarcinomaTp53
PEHO SyndromeIgf1
penile neoplasmCcnd1 , Hras , Kras , Pik3ca , Tp53
Penis AgenesisSrd5a2
Penttinen-Aula SyndromePdgfrb
peptic esophagitisEgfr
Perennial Allergic RhinitisGstp1
Periapical DiseasesPdgfb
perinatal necrotizing enterocolitisEgf , Ikbkg
peripheral nervous system diseaseCasp9 , Gstp1 , Igf1 , Igf1r
peripheral nervous system neoplasmPten
Peritoneal NeoplasmsCtnnb1
peritonitisGsk3b , Gstp1
permanent neonatal diabetes mellitusIns1 , Ins2
persistent fetal circulation syndromePten
Pfeiffer syndromeFgfr1 , Fgfr2
Phelan-McDermid syndromeIns2
phobic disorderHras
Phyllodes TumorCdkn1a , Ctnnb1 , Egfr , Rb1 , Tp53
Pick's diseaseCreb1
pilocytic astrocytomaKras
pilomatrixomaCtnnb1
Pituitary NeoplasmsCdkn1a , Cdkn1b , Igf1 , Rb1
Plagiocephaly, NonsynostoticFgfr2
Plaque, AtheroscleroticIgf1
plasmacytomaBcl2 , Braf , Hras , Kras , Nras , Pik3ca , Tp53
Plasmodium falciparum malariaGstp1
pleomorphic xanthoastrocytomaBraf , Creb3l2 , Egfr , Tp53
Pneumococcal MeningitisRela
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaEgf , Ikbkb
PoisoningGsk3b
polycystic kidney diseaseMtor
polycystic ovary syndromeAkt2 , Ar , Bcl2 , Ccne2 , Igf1 , Ins2
polydactylyPten
PolymicrogyriaAkt3
PolyploidyTp53
portal hypertensionHsp90aa1 , Mtor , Pik3r1 , Pten
post-traumatic stress disorderBcl2 , Casp9 , Mdm2
Postmenopausal OsteoporosisAr , Igf1
pre-eclampsiaErbb2 , Fgfr2 , Gstp1
pre-malignant neoplasmAkt1 , Casp9 , Ccnd1 , Cdkn1a , Egf , Gstp1 , Hras , Mdm2 , Nfkbia , Tp53
Precocious PubertyIgf1
precursor B lymphoblastic lymphoma/leukemiaCcnd1 , Pdgfra , Tcf3 , Tp53
precursor lymphoblastic lymphoma/leukemiaBcl2 , Ccnd1 , Crebbp , Gstp1 , Kras , Nras , Rb1 , Tcf3 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaBcl2 , Kras , Mtor , Pdgfra
Pregnancy ComplicationsNcoa2
Premature AgingBcl2 , Cdkn1a , Foxo1 , Igf1r , Mdm2 , Tp53
priapismBcl2 , Mdm2
primary biliary cirrhosisCdkn1a , Nfkb1 , Rela
primary hyperparathyroidismCdkn1b
primary hypomagnesemiaEgf
primary open angle glaucomaCdkn1a , Tp53
progeriaIgf1
Progressive Osseous HeteroplasiaCtnnb1
proliferative diabetic retinopathyPdgfb
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Ar , Braf , Ccne2 , Chuk , Creb3l4 , Ctnnb1 , Erbb2 , Fgfr1 , Grb2 , Hras , Igf1r , Ikbkb , Map2k1 , Mapk1 , Nfkbia , Pdgfa , Pdgfra , Pdpk1 , Pik3ca , Pik3cb , Pten , Raf1 , Rela , Tp53
prostate cancerAkt1 , Akt2 , Akt3 , Ar , Bcl2 , Ccnd1 , Cdk2 , Cdkn1a , Chuk , Ctnnb1 , E2f1 , E2f3 , Egfr , Ep300 , Erbb2 , Fgfr1 , Fgfr2 , Foxo1 , Grb2 , Gstp1 , Igf1r , Ikbkb , Ins2 , Kras , Lef1 , Mtor , Ncoa2 , Nfkb1 , Nfkbia , Nkx3-1 , Nras , Pdgfrb , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pten , Raf1 , Rb1 , Sos1 , Srd5a2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Prostate Cancer, SomaticAr , Pten
prostate carcinomaAkt2 , Atf4 , Bad , Igf1r , Pdgfb , Pdgfd , Tp53
prostate carcinoma in situAr , Ccnd1 , Ccne1 , Cdkn1b , Creb3l4 , Fgfr1 , Fgfr2 , Gstp1 , Igf1 , Kras , Lef1 , Pten , Rela
prostatic hypertrophyAr , Atf4 , Bad , Gstp1 , Igf1r , Pdgfb , Pdgfd , Pten , Rela , Srd5a2
Prostatic NeoplasmsAkt1 , Ar , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Chuk , Creb3l4 , Crebbp , Ctnnb1 , Egf , Egfr , Erbb2 , Foxo1 , Gsk3b , Gstp1 , Hras , Hsp90ab1 , Hsp90b1 , Igf1 , Ins2 , Kras , Mapk3 , Mdm2 , Ncoa2 , Ncor2 , Nkx3-1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pten , Rb1 , Rela , Srd5a2 , Tgfa , Tp53
Proteus syndromeAkt1 , Pten
Pseudomonas InfectionsGstp1
Pseudovaginal Perineoscrotal HypospadiasSrd5a2
psoriasisCdkn1a , Gstp1 , Igf1 , Ikbkb , Nfkbia , Tgfa , Tp53
PTEN hamartoma tumor syndromePik3ca , Pten
pterygiumTp53
pulmonary edemaTgfa
pulmonary emphysemaGstp1 , Nfkbia
pulmonary fibrosisBad , Egf , Egfr , Gstp1 , Hsp90ab1 , Igf1 , Pdgfa , Pdgfb , Pdgfra , Tgfa
pulmonary hypertensionBcl2 , Cdkn1a , Cdkn1b , Egfr , Fgfr1 , Foxo1 , Mapk1 , Mapk3 , Mtor , Pdgfa , Pdgfb , Rela , Tgfa , Tp53
pulmonary valve stenosisBraf , Hras , Sos1
pycnodysostosisIgf1
Radiation Injuries, ExperimentalCasp9 , Mapk1 , Mapk3
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
rectal neoplasmCdkn1b , Egfr , Nras , Pik3ca , Pik3cb
RecurrenceCcne1 , Erbb2 , Hras , Kras
renal carcinomaMtor , Nras , Pik3ca , Pten , Tp53
renal cell carcinomaAkt1 , Akt3 , Bad , Bcl2 , Ccnd1 , Ccne1 , Cdk2 , Cdkn1b , Ctnnb1 , Egfr , Erbb2 , Fgfr1 , Gstp1 , Igf1r , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pdgfra , Pdgfrb , Pik3ca , Pik3r1 , Pten , Rb1 , Rela , Tp53
renal fibrosisKras , Mapk1
renal hypertensionCdkn1a
renal hypomagnesemia 3Egf
renal hypomagnesemia 4Egf
renal hypomagnesemia 5 with ocular involvementEgf
renovascular hypertensionPdgfa , Rela
Reperfusion InjuryAkt1 , Bad , Bcl2 , Casp9 , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Egf , Ep300 , Gstp1 , Igf1 , Pik3r1 , Pten , Rela , Tp53
respiratory failureIgf1r
Respiratory SoundsGstp1
Respiratory System AbnormalitiesPdgfra
respiratory system diseaseGstp1
Retina Reperfusion InjuryBad , Bcl2
retinal degenerationBcl2
retinal detachmentCasp9 , Fgfr1
retinal diseasePdgfb
Retinal NeovascularizationMtor
retinitis pigmentosaFgfr2 , Pten
retinoblastomaRb1
retinopathy of prematurityIgf1
RetrognathiaEp300
RhabdomyolysisIns2
rhabdomyosarcomaTp53
rheumatic heart diseaseIgf1
rheumatoid arthritisHsp90aa1 , Pdgfb
RhinosinusitisIgf1
Right Ventricular HypertrophyAkt1 , Igf1 , Igf1r , Mtor , Tgfa
Rubinstein-Taybi syndromeCrebbp , Ep300
Saethre-Chotzen syndromeFgfr2
Salivary Gland NeoplasmsCcnd1 , Cdkn1a
SAPHO syndromeMdm2 , Tp53
sarcoidosisCdkn1a
sarcomaGstp1 , Mdm2 , Pik3ca , Tp53
SarcopeniaAr , Bcl2 , Cdkn1a , Igf1 , Nfkbia
Scaphocephaly, Maxillary Retrusion, and Mental RetardationFgfr2
schizophreniaAkt1 , Creb1 , Egf , Egfr , Fgfr1 , Gsk3b , Mapk3 , Mtor , Pik3cb , Tp53
Schnyder corneal dystrophyMtor
sciatic neuropathyCdkn1b , Creb1 , Fgfr1 , Gsk3b , Mtor , Nfkbia , Pdgfra , Pdgfrb
scoliosisCrebbp
scrapieCasp9
sebaceous gland neoplasmCdkn1a , Lef1
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaHras , Kras , Pdgfra , Rb1
senile cataractCdkn1b , Gstp1
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisBad , Casp9 , Cdkn1a , Ep300 , Gsk3b , Mapk1 , Mapk3 , Mtor , Rela
Septic PeritonitisPik3r1
serous cystadenocarcinomaCdkn1a , Tp53
Severe Growth Restriction with Distinctive FaciesIns1
severe nonproliferative diabetic retinopathyPdgfrb
Sezary's diseaseBraf , Cdkn1b , Crebbp , Mapk1 , Pten , Rb1 , Tp53
ShockMapk1 , Mapk3
Shock, HemorrhagicBad , Bcl2 , Mapk1 , Mtor , Rela
SHORT SyndromePik3r1
sickle cell anemiaMdm2
silicosisPten
Silver-Russell syndromeIns1
sinusitisPdgfb
Sjogren's syndromeE2f1 , Nfkbia
Skin AbnormalitiesChuk , Fgfr2
skin benign neoplasmHras
skin cancerChuk
skin diseaseFgfr2 , Pten
skin melanomaAkt1 , Braf , Ctnnb1 , Hras , Map2k1 , Map2k2 , Nras , Pdgfra , Pik3ca , Pten , Raf1
Skin NeoplasmsAkt1 , Cdkn1a , Ctnnb1 , Hras , Igf1 , Igf1r , Rela , Tp53
Skull FracturesIgf1
small cell carcinomaMtor , Rb1 , Tp53
small intestine adenocarcinomaMap2k1 , Map2k2
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Smith-Magenis syndromeMap2k2
Soft Tissue NeoplasmsBcl2
spermatocytomaHras
spina bifidaCrebbp , Fgfr2 , Pdgfra
Spinal Cord InjuriesAkt1 , Bcl2 , Casp9 , Ccne1 , Cdkn1b , Egfr , Hsp90ab1 , Mdm2 , Mtor , Nfkbia , Pdgfb , Rela , Tp53
Spinal Cord Reperfusion InjuryBad
spinal muscular atrophyAr
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
sporadic breast cancerPten
Sporadic Papillary Renal Cell CarcinomaBraf , Erbb2 , Hras , Mtor , Pik3ca , Tp53
squamous cell carcinomaAkt1 , Bcl2 , Ccnd1 , Cdkn1a , Crebbp , Egfr , Ep300 , Fgfr1 , Fgfr2 , Gstp1 , Hras , Kras , Mapk1 , Mapk3 , Pik3ca , Tp53
Stargardt Disease 3Fgfr1
status epilepticusBcl2 , Ccnd1 , Gsk3b , Mtor , Rela
Stevens-Johnson syndromeCtnnb1 , Ep300 , Rb1
stomach cancerCtnnb1 , Erbb2 , Fgfr2 , Kras , Nras , Pik3ca , Tp53
stomach carcinomaCdkn1a , Kras
stomach diseasePten
Stomach NeoplasmsCcnd1 , Cdkn1a , Cdkn1b , Egfr , Erbb2 , Fgfr2 , Gstp1 , Hras , Kras , Mapk1 , Mapk3 , Pik3ca , Tgfa , Tp53
StrokeAkt1 , Ctnnb1 , Igf1 , Igf1r , Pdgfra , Pik3ca , Tgfa
Subarachnoid HemorrhageBcl2 , Casp9 , Gsk3b
substance-induced psychosisAkt1 , Gstp1
substance-related disorderGsk3b , Pten
synovial sarcomaBcl2
systemic lupus erythematosusCdkn1a , Ep300 , Tcf7
T-Cell LymphomaAkt1 , Cdkn1a , Ep300 , Fgfr1 , Tp53
TachycardiaGsk3b , Ins2
tauopathyGsk3b
temporal lobe epilepsyMtor
Temporomandibular Joint DisordersMtor
teratomaCtnnb1
testicular cancerGstp1
Testicular NeoplasmsCdkn1b
Testis Reperfusion InjuryBcl2 , Casp9 , Mapk1 , Mapk3
ThinnessIgf1
thrombosisPik3cb
Thumb DeformityCrebbp , Ep300
thymomaHras , Tp53
Thymus NeoplasmsTp53
thyroid cancerMapk1
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdkn1a , Hras , Kras , Nras , Pdgfa , Pik3ca , Pten , Tp53
Tibial FracturesPdgfb
Tobacco Use DisorderEgfr
Tongue NeoplasmsBcl2 , Cdkn1a , Hras , Igf1 , Tp53
tongue squamous cell carcinomaCdkn1a , Egfr , Tp53
Tooth AbnormalitiesFgfr2
toxic encephalopathyGstp1 , Igf1r , Mtor
Tracheoesophageal FistulaFgfr2
transient cerebral ischemiaBad , Bcl2 , Casp9 , Creb1 , Ep300 , Fgfr1 , Igf1 , Ikbkb , Mdm2 , Nfkb1 , Pten
transitional cell carcinomaAkt1 , Bcl2 , Braf , Ccnd1 , Cdkn1a , Cdkn1b , Crebbp , Ctnnb1 , Egfr , Ep300 , Erbb2 , Fgfr1 , Fgfr2 , Hras , Kras , Map2k1 , Mapk1 , Mtor , Nras , Pik3ca , Pten , Tp53
Transplant RejectionIkbkb , Nfkbia , Pdgfd , Pdgfrb
Trichilemmoma Hras
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaMapk1 , Mapk3
Trigonocephaly 1Fgfr1
trilateral retinoblastomaRb1
Tumor Predisposition SyndromePten , Tp53
Turner syndromeIgf1
Tympanic Membrane PerforationFgfr1
type 1 diabetes mellitusCasp9 , E2f1 , Egfr , Foxo1 , Igf1 , Ins2
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusAkt1 , Akt2 , Ar , Bad , Bcl2 , Braf , Casp9 , Egfr , Ep300 , Fgfr1 , Foxo1 , Gsk3b , Gstp1 , Igf1 , Igf1r , Ikbkb , Ins1 , Ins2 , Mapk1 , Mapk3 , Mtor , Nfkb1 , Pik3cb , Pik3r1 , Rela , Tcf7l2
ulcerative colitisCdkn1a , Igf1r , Rela
umbilical herniaFgfr1 , Fgfr2
UnconsciousnessPten
Ureteral CalculiGstp1
ureteral obstructionAkt1 , Casp9 , Mapk1 , Mapk3 , Mtor , Pdgfb , Rela
urethral obstructionMapk1
urinary bladder cancerAkt1 , Bcl2 , Casp9 , Ccnd1 , Ccne1 , Cdkn1a , Cdkn1b , Crebbp , Ctnnb1 , E2f1 , Egfr , Ep300 , Erbb2 , Fgfr2 , Gstp1 , Hras , Igf1 , Kras , Mdm2 , Mtor , Pten , Rb1 , Rela , Tp53
Urinary Bladder NeoplasmHras , Kras , Rb1
Urinary IncontinenceMapk1
Urogenital NeoplasmsTp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53
uterine carcinosarcomaErbb2 , Fgfr2 , Hras , Pik3ca , Pik3r1 , Pten , Tp53
Uterine Cervical NeoplasmsAkt1 , Ccnd1 , Ccne1 , Cdk2 , Cdkn1a , Cdkn1b , Crebbp , Ctnnb1 , Egfr , Ep300 , Erbb2 , Fgfr2 , Hras , Kras , Mapk1 , Mtor , Pik3ca , Pten , Rela , Tp53
Uterine NeoplasmsBraf , Cdkn1b , Ctnnb1 , Erbb2 , Fgfr2 , Hras , Kras , Map2k1 , Mtor , Nras , Pdgfra , Pik3ca , Pik3r1 , Pten , Sos1 , Tp53
uveal melanomaIgf1
uveitisRela
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9
Vascular CalcificationCtnnb1
vascular dementiaFgfr1 , Gsk3b , Igf1 , Igf1r , Mtor , Tp53
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1 , Nfkbia
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
ventricular septal defectBraf
Ventricular TachycardiaRaf1
vesicoureteral refluxIgf1r
vestibular diseaseGstp1
viral encephalitisE2f1
visual epilepsyBad , Ccnd1 , Creb3l1 , Fgfr1 , Ins2 , Pdgfb , Pik3ca , Pten
vitiligoPik3r1
Volvulus Of MidgutFgfr2
von Hippel-Lindau diseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsTp53
Wallerian DegenerationErbb2
Weight GainPik3ca
Weight LossIns2
Weissenbacher-Zweymuller syndromeMapk1
withdrawal disorderCreb1 , Mapk1 , Mapk3
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf , Igf1 , Pdgfa , Pdgfb , Pdgfrb
xeroderma pigmentosumTp53
Zinc DeficiencyIgf1
Zollinger-Ellison syndromeEgf , Igf1r
Pathway Annotations Associated with Genes in the prostate cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Grb2 , Hras , Ikbkb , Ikbkg , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nfkb1 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Chuk , Creb1 , Hras , Ikbkb , Map2k2 , Mapk1 , Nfkb1 , Nfkbia , Pdpk1 , Pik3ca
aldosterone signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Kras , Mapk1 , Mapk3 , Ncoa2 , Ncor2 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered androgen signaling pathwayAr , Ncoa2 , Ncor2
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2
altered insulin-like growth factor signaling pathwayIgf1
altered p53 signaling pathwayMdm2 , Tp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayCtnnb1 , Tcf7l2
Alzheimer's disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad , Bcl2 , Casp9 , Tp53
androgen signaling pathwayAr , Crebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
angiotensin II signaling pathwayPdpk1
antigen processing and presentation pathwayCreb1 , Hsp90aa1 , Hsp90ab1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2
basal cell carcinoma pathwayCtnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2 , Pdgfra , Pdgfrb
cardiovascular system disease pathwayIgf1
cell cycle pathway, mitoticCcnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Cdkn1b , Crebbp , E2f1 , E2f3 , Ep300 , Gsk3b , Mdm2 , Rb1 , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Igf1 , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pdgfa , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Tgfa , Tp53
cerium oxide nanoparticle response pathwayFgfr1
cetuximab pharmacodynamics pathwayEgfr
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Chuk , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdkn1a , Cdkn1b , Chuk , E2f1 , E2f3 , Grb2 , Hras , Ikbkb , Ikbkg , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Sos1 , Sos2 , Tp53
codeine and morphine pharmacodynamics pathwayHsp90b1
codeine and morphine pharmacokinetics pathwayHsp90b1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2 , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cortisol signaling pathwayCrebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
cytokine mediated signaling pathwayEgf , Egfr , Pdgfa , Pdgfra , Pdgfrb
dilated cardiomyopathy pathwayIgf1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Ctnnb1 , Egf , Egfr , Igf1 , Igf1r , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayEgf , Egfr , Fgfr2 , Hras , Igf1r , Mdm2 , Pdgfra
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endoplasmic reticulum stress - the unfolded protein response pathwayAtf4 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4
Endoplasmic Reticulum-associated degradation pathwayAtf4 , Bcl2 , Hsp90aa1 , Hsp90ab1 , Hsp90b1
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoebiasis pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Cdkn1b , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2 , Grb2 , Hras , Nfkb1 , Pik3r1 , Sos1
estrogen signaling pathwayCrebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
etoposide pharmacodynamics pathwayHsp90b1
etoposide pharmacokinetics pathwayHsp90b1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Fgfr1 , Fgfr2 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAkt1 , Ar , Cdkn1b , Creb1 , Crebbp , Ep300 , Ins2 , Nkx3-1
G1 phase pathwayCcnd1
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcnd1 , Ccne1 , Ccne2 , Cdk2 , Cdkn1a , Cdkn1b , Rb1
gefitinib pharmacodynamics pathwayEgfr
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdkn1a , E2f1 , E2f3 , Egf , Egfr , Grb2 , Hras , Igf1 , Igf1r , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mdm2 , Mtor , Nras , Pdgfa , Pdgfb , Pdgfra , Pdgfrb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Sos1 , Sos2 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glutathione conjugation pathwayGstp1
glutathione metabolic pathwayGstp1
glyburide pharmacodynamics pathwayIns2
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayFgfr1
gonadotropin-releasing hormone signaling pathwayAtf4 , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdkn1a , Chuk , Egf , Egfr , Grb2 , Gsk3b , Hras , Ikbkb , Ikbkg , Kras , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Sos1 , Sos2 , Tp53
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300
Huntington's disease pathwayCasp9 , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Ep300 , Tp53
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayAkt1 , Creb1 , Crebbp , Ep300 , Ncoa2
ibuprofen pharmacodynamics pathwayHsp90b1
ibuprofen pharmacokinetics pathwayHsp90b1
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Crebbp , Ep300 , Gsk3b , Ikbkb , Map2k1 , Map2k2 , Mapk1