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Type 2 diabetes mellitus (T2D) is reaching epidemic proportions worldwide, yet the genetic underpinnings of the disease continue to be remarkably elusive. The importance and impact of environmental factors such as diet and lifestyle on the susceptibility of the disease only add additional challenges to the identification of genetic causes. While it is known that several pathways important for the maintenance of glucose homeostasis are altered in T2D, less is known about the molecular mech

Pathway Diagram:

Ariadne Genomics Inc. altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered insulin responsive facilitative sugar transporter mediated glucose transport pathway Insr Ins2 Irs1 Sh2b2 Irs2 Ins1 Ins1 ---- Insr Irs1 ---- Pik3r1 Irs2 ---- Pik3r1 Grb14 ---| Insr Grb10 ---| Insr Enpp1 ---| Insr Pkcs ---| Insr Pkcs ---| Irs1 Pik3r1 Grb2 ---- Irs2 Irs2 ---- Ptpn11 Grb2 ---- Sos2 Grb2 ---- Shc1 Ptprf ---| Insr Ptpn1 ---| Insr Ptpn11 Ptprf Enpp1 Ptpn1 Pkcs Irs4 Irs3 Grb14 Grb10 Grb2 ---- Sos1 Socs1 ---| Insr Socs6 ---| Insr Socs3 ---| Insr Socs7 ---| Insr Sos1 Sos2 Grb2 Grb2 ---- Irs1 Shc1 Socs7 Socs6 Socs3 Socs1

Genes in Pathway:

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altered insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayaltered insulin responsive facilitative sugar transporter mediated glucose transport pathway
Pathwayaltered phosphatidylinositol 3-kinase-Akt signaling pathwaysignaling pathway
Pathwayaltered extracellular signal-regulated Raf/Mek/Erk signaling pathway

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the altered insulin signaling pathway

References Associated with the altered insulin signaling pathway:

Ontology Path Diagram:

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