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Scatter factor/hepatocyte growth factor (Sf/Hgf) signaling pathway is a central regulator of invasive growth, a complex multi-step program required for embryonic and organ development as well as wound healing in adult cells but also characteristic of cancer progression. Met - the receptor for Hgf has first been identified in the 1980s as on oncogene. Both the ligand and the receptor are heterodimers that result from the processing of precursor molecules. Binding of Hgf leads to receptor autophos

Pathway Diagram:

Ariadne Genomics Inc. phosphatidylinositol 3-kinase-Akt signaling pathway Crkl The extracellular signal-regulated RAF/MEK/ERK pathway PY1356 PY1349 Src Cbl Met Hgf p-tyr Gab1 Grb2 Pik3r1 Shc1 Pptn11 Sos Plcg1

Genes in Pathway:

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scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:2299174
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:1642762
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:1642762
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1642762
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1642762
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1642762
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1642762
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:1642762
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1642762
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1642762
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1642762
altered scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241

Pathway Gene Annotations

Disease Annotations Associated with Genes in the scatter factor/hepatocyte growth factor signaling pathway
Disease TermsGene Symbols
acute kidney failureMet
Acute Liver FailureHgf , Met
acute myeloid leukemiaCbl , Hgf , Met , Ptpn11
adenocarcinomaMet , Ptpn11
adult T-cell leukemiaPlcg1
adult-onset Still's diseaseHgf
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Alzheimer's diseasePik3r1 , Plcg1 , Shc1
amyotrophic lateral sclerosis type 1Shc1
angle-closure glaucomaHgf
Animal HepatitisMet
Animal Mammary NeoplasmsPik3r1
aortic valve stenosisPtpn11
arteriosclerosisHgf , Met
astrocytomaHgf , Met , Ptpn11
atrial fibrillationHgf
autistic disorderCrkl , Met
autosomal recessive nonsyndromic deafness 26Gab1
autosomal recessive nonsyndromic deafness 39Hgf
autosomal recessive nonsyndromic deafness 97Met
autosomal recessive polycystic kidney diseaseSrc
B-Cell Chronic Lymphocytic LeukemiaCbl
Barrett's esophagusHgf
Bile Duct NeoplasmsMet
biliary tract benign neoplasmHgf
bilirubin metabolic disorderHgf
brain infarctionHgf
brain ischemiaSrc
Brain NeoplasmsPik3r1 , Ptpn11
breast cancerGrb2 , Hgf , Met , Plcg1
breast carcinomaPlcg1
Breast NeoplasmsCrkl , Pik3r1 , Src
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
carcinomaMet , Pik3r1
cardiofaciocutaneous syndromePtpn11
CardiomegalyMet , Shc1 , Src
carotid artery diseaseHgf
Carotid Artery InjuriesCbl
central nervous system diseaseHgf
Chemical and Drug Induced Liver InjuryShc1
cholangiocarcinomaHgf , Met
Choroidal NeovascularizationHgf
Chronic HepatitisHgf , Met , Shc1
chronic lymphocytic leukemiaPtpn11
chronic myeloid leukemiaCrkl
cognitive disorderMet
colon cancerSrc
colon carcinomaCrkl
Colonic NeoplasmsPik3r1 , Src
colorectal cancerPik3r1 , Src
Colorectal NeoplasmsMet , Pik3r1 , Ptpn11 , Src
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital diaphragmatic herniaCbl , Met
congestive heart failureCbl
Copper-Overload CirrhosisHgf , Met
coronary artery diseaseHgf
Costello syndromePtpn11
cutaneous T cell lymphomaPlcg1
Developmental DisabilitiesCbl
diabetes mellitusHgf
Diabetes Mellitus, Experimental Hgf , Met , Pik3r1 , Plcg1
Diabetic NephropathiesHgf
diabetic neuropathyHgf
diabetic retinopathyHgf
DiGeorge syndromeCrkl
dilated cardiomyopathyPtpn11
disease of cellular proliferationMet , Pik3r1 , Src
disease of metabolismPtpn11
Distal Arthrogryposis Multiplex Congenita, Type 1Met
Distal Arthrogryposis, Type 1AMet
ductal carcinoma in situSrc
embryonal rhabdomyosarcomaPtpn11
endometrial adenocarcinomaPik3r1
endometrial cancerPik3r1
endometrial carcinomaGrb2 , Pik3r1
Endometrial NeoplasmsMet
Esophageal NeoplasmsMet
Experimental ArthritisCbl
Experimental LeukemiaCbl
Experimental Liver CirrhosisHgf , Met
Experimental Liver NeoplasmsHgf , Met
Experimental MelanomaHgf
Experimental NeoplasmsHgf
Facial Nerve InjuriesHgf
Failure to ThrivePtpn11
familial hyperlipidemiaShc1
fatty liver diseaseShc1
Fetal Growth RetardationPtpn11
Gallbladder NeoplasmsHgf , Met
gastric adenocarcinomaPtpn11
genetic diseaseCbl , Pik3r1 , Ptpn11
gestational diabetesMet
Gilles de la Tourette syndromeMet
glioblastoma multiformeMet , Pik3r1
Graft vs Host DiseaseHgf
Growth DisordersCbl
growth hormone secreting pituitary adenomaPtpn11
Hearing LossHgf
Hematologic NeoplasmsCbl
hepatocellular adenomaPtpn11
hepatocellular carcinomaHgf , Met , Shc1
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesMet
hyperglycemiaCbl , Shc1
hypertensionHgf , Pik3r1 , Src
Hypertensive NephropathyShc1
hypertrophic cardiomyopathyPtpn11
Immunodeficiency 36Pik3r1
Insulin ResistancePik3r1 , Shc1
interstitial lung diseaseHgf
invasive ductal carcinomaCrkl , Met
inverted papillomaHgf
juvenile myelomonocytic leukemiaCbl , Ptpn11
Kidney NeoplasmsMet
Kidney Reperfusion InjurySrc
large cell carcinomaMet
Left Ventricular HypertrophyShc1
LEOPARD syndromePtpn11
Limb IschemiaHgf
liver benign neoplasmHgf , Met
liver cirrhosisHgf
Liver InjuryHgf
localized sclerodermaHgf
lung adenocarcinomaPik3r1 , Ptpn11
lung carcinomaCrkl
Lung NeoplasmsMet
lung small cell carcinomaPik3r1
lung squamous cell carcinomaPtpn11
male infertilityCbl
malignant gliomaHgf , Met
malignant mesotheliomaHgf , Met
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalPik3r1
melanomaCbl , Pik3r1
Metabolic SyndromeHgf
multiple myelomaCbl , Met , Ptpn11
myeloid neoplasmCbl
myocardial infarctionHgf
Myocardial IschemiaHgf
Myocardial Reperfusion InjuryCbl
Nasal PolypsHgf , Met
Nematode InfectionsPik3r1
Neoplasm InvasivenessHgf , Met , Src
Neoplasm MetastasisHgf , Met , Src
Neoplasms, Cystic, Mucinous, and SerousMet
Nerve Sheath NeoplasmsHgf , Met
neuroblastomaHgf , Met , Ptpn11
Neurodevelopmental DisordersPtpn11
non-small cell lung carcinomaCbl , Met
nonsyndromic deafnessMet
Noonan Like SyndromeCbl , Ptpn11
Noonan syndromeCbl , Ptpn11
Noonan syndrome 1Ptpn11
Noonan syndrome 3Ptpn11
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
obesityHgf , Pik3r1
Ollier diseasePtpn11
Optic Nerve InjuriesHgf
oral squamous cell carcinomaMet , Plcg1
Osteofibrous DysplasiaMet
ovarian cancerCrkl , Met
Ovarian NeoplasmsMet , Pik3r1
pancreatic cancerHgf , Met
pancreatic ductal carcinomaMet
pancreatitisHgf , Met
papillary renal cell carcinomaMet
Parkinson's diseaseHgf
Parkinsonian DisordersSrc
pleomorphic xanthoastrocytomaHgf , Met
polycystic kidney diseasePlcg1
polycystic ovary syndromeGab1
Polyomavirus InfectionsHgf
portal hypertensionPik3r1
precursor T-lymphoblastic lymphoma/leukemiaPtpn11
proliferative vitreoretinopathyHgf
prostate adenocarcinomaGrb2
prostate cancerGrb2 , Pik3r1 , Src
prostate carcinomaCrkl , Met
Prostatic NeoplasmsMet , Pik3r1
pulmonary fibrosisHgf
RASopathiesCbl , Ptpn11
renal carcinomaMet
renal cell carcinomaMet , Pik3r1
Reperfusion InjuryHgf , Met , Pik3r1 , Src
Retina Reperfusion InjuryHgf
retinal degenerationHgf
Retinal NeovascularizationHgf
retinitis pigmentosaHgf
retinopathy of prematurityHgf
rheumatoid arthritisHgf
schizophreniaCbl , Crkl , Hgf , Met
sciatic neuropathyHgf
Septic PeritonitisPik3r1
Sezary's diseasePlcg1
SHORT SyndromePik3r1
skin cancerCrkl
Skin NeoplasmsHgf
Spinal Cord InjuriesHgf , Met
squamous cell carcinomaHgf , Met , Ptpn11
status epilepticusSrc
Stomach NeoplasmsMet
StrokeHgf , Src
systemic sclerodermaHgf
tetralogy of FallotPtpn11
tongue squamous cell carcinomaHgf , Met
transient cerebral ischemiaCbl
Tumor Predisposition SyndromeMet
type 1 diabetes mellitusCbl
type 2 diabetes mellitusPik3r1 , Src
urinary bladder cancerSrc
uterine carcinosarcomaPik3r1
Uterine NeoplasmsPik3r1
vascular diseaseHgf
velocardiofacial syndromeCrkl
visual epilepsyHgf
vitiligoHgf , Pik3r1
Williams-Beuren syndromeSrc
Wounds and InjuriesHgf
Wounds, PenetratingHgf
Pathway Annotations Associated with Genes in the scatter factor/hepatocyte growth factor signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayGrb2 , Pik3r1
aldosterone signaling pathwayPik3r1
altered Reelin signaling pathwaySrc
altered scatter factor/hepatocyte growth factor signaling pathwayMet
apoptotic cell death pathwayPik3r1
B cell receptor signaling pathwayGrb2 , Pik3r1
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
calcium/calcium-mediated signaling pathwayPlcg1
ceramide signaling pathwayPik3r1
Chagas disease pathwayPik3r1
chemokine mediated signaling pathwayCrkl , Grb2 , Pik3r1 , Shc1
chronic myeloid leukemia pathwayCbl , Crkl , Grb2 , Pik3r1 , Ptpn11 , Shc1
colorectal cancer pathwayPik3r1
cytokine mediated signaling pathwayHgf , Met
dopamine signaling pathwaySrc
E-cadherin signaling pathwayHgf , Pik3r1 , Plcg1 , Src
eicosanoid signaling pathwaySrc
endocytosis pathwayCbl , Met , Src
endometrial cancer pathwayGrb2 , Pik3r1
endothelin signaling pathwaySrc
Entamoebiasis pathwayPik3r1
ephrin - ephrin receptor bidirectional signaling axisCbl , Crkl , Grb2 , Pik3r1 , Plcg1 , Src
epidermal growth factor/neuregulin signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
erythropoietin signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1
estrogen signaling pathwaySrc
FasL mediated signaling pathwayPik3r1 , Src
Fc epsilon receptor mediated signaling pathwayGrb2 , Pik3r1 , Plcg1
Fc gamma receptor mediated signaling pathwayCrkl , Pik3r1 , Plcg1
fibroblast growth factor signaling pathwayCbl , Gab1 , Grb2 , Hgf , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
glioma pathwayGrb2 , Pik3r1 , Plcg1 , Shc1
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayGrb2 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Pik3r1 , Ptpn11 , Shc1
Hedgehog signaling pathwayPik3r1
hepatitis C pathwayGrb2 , Pik3r1
influenza A pathwayPik3r1
inositol phosphate metabolic pathwayPlcg1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCbl
insulin signaling pathwayCbl , Crkl , Grb2 , Pik3r1 , Ptpn11 , Shc1
insulin-like growth factor signaling pathwayCrkl , Grb2 , Pik3r1 , Ptpn11 , Shc1
interleukin-1 signaling pathwayPik3r1
interleukin-2 signaling pathwayGrb2 , Pik3r1 , Ptpn11 , Shc1
interleukin-23 signaling pathwayPik3r1
interleukin-3 signaling pathwayGrb2 , Pik3r1 , Ptpn11 , Shc1
interleukin-4 signaling pathwayCbl , Grb2 , Pik3r1 , Shc1
interleukin-5 signaling pathwayGrb2 , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayGab1 , Grb2 , Pik3r1 , Ptpn11
Jak-Stat signaling pathwayCbl , Grb2 , Pik3r1 , Ptpn11
leptin system pathwayPtpn11
malaria pathwayHgf , Met
measles pathwayPik3r1
melanoma pathwayHgf , Met , Pik3r1
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayCrkl , Grb2 , Shc1
mTOR signaling pathwayPik3r1
N-cadherin signaling pathwayPik3r1 , Plcg1 , Ptpn11
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayCrkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1
non-small cell lung carcinoma pathwayGrb2 , Met , Pik3r1 , Plcg1
Notch signaling pathwayCbl
nuclear factor kappa B signaling pathwayPik3r1 , Src
pancreatic cancer pathwayMet , Pik3r1
phosphatidylinositol 3-kinase class I signaling pathwayPik3r1 , Plcg1 , Src
phosphatidylinositol 3-kinase signaling pathwayPik3r1 , Plcg1
phosphatidylinositol 3-kinase-Akt signaling pathwayPik3r1 , Src
phosphoinositide metabolic pathwayPik3r1
platelet-derived growth factor signaling pathwayCbl , Crkl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
prostate cancer pathwayGrb2 , Pik3r1
Reelin signaling pathwayCbl , Crkl , Pik3r1 , Src
renal cell carcinoma pathwayCrkl , Gab1 , Grb2 , Hgf , Met , Pik3r1 , Ptpn11
Rho/Rac/Cdc42 mediated signaling pathwayCbl
scatter factor/hepatocyte growth factor signaling pathwayCbl , Crkl , Gab1 , Grb2 , Hgf , Met , Pik3r1 , Plcg1 , Ptpn11 , Shc1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung carcinoma pathwayPik3r1
somatostatin signaling pathwayPtpn11 , Src
sphingosine 1-phosphate signaling pathwayPlcg1 , Src
syndecan signaling pathwayHgf , Src
T cell receptor signaling pathwayCbl , Grb2 , Pik3r1 , Plcg1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayShc1
Toll-like receptor signaling pathwayPik3r1
toxoplasmosis pathwayPik3r1
Trail mediated signaling pathwayPik3r1
transforming growth factor-beta Smad dependent signaling pathwayGrb2 , Shc1
tuberculosis pathwaySrc
type 2 diabetes mellitus pathwayPik3r1
type II interferon signaling pathwayCbl , Crkl , Pik3r1 , Ptpn11
ubiquitin/proteasome degradation pathwayCbl , Src
vascular endothelial growth factor signaling pathwayCbl , Gab1 , Grb2 , Pik3r1 , Plcg1 , Ptpn11 , Src

References Associated with the scatter factor/hepatocyte growth factor signaling pathway:

Ontology Path Diagram:

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