ANDROGEN SIGNALING PATHWAY (PW:0000564)

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Description

The androgen signaling pathway plays important roles in the development and maintenance of male phenotype and reproductive functions and in a range of other processes in nonreproductive tissues. Testosterone, the main androgen, is primarily synthesized in the testes; others are synthesized in the adrenal gland and can be converted to testosterone in peripheral tissues. In some of the target cells, testosterone can be converted to its very potent metabolite dehydrotestosterone (DHT). Like all st

Pathway Diagram:

Ariadne Genomics Inc. Ar chaperones Translocated Ar complex Ar target genes Ar coactivators Ar corepressors DHT testosterone Ar Translocated Ar complex ---> Ar target genes Ar ---> Translocated Ar complex Ar ---- DHT Ar ---- testosterone Ar coactivators ---- Translocated Ar complex Ar corepressors ---- Translocated Ar complex Ar ---- Ar chaperones testosterone biosynthetic pathway Ar corepressors ---| Translocated Ar complex Ar coactivators --+> Translocated Ar complex
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Genes in Pathway:

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androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326084
G Carm1 coactivator-associated arginine methyltransferase 1 JBrowse link 8 22,577,723 22,622,555 RGD:2326123
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2326123
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 JBrowse link 19 22,569,999 22,588,143 RGD:2326084
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:2326123
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:2326084
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:2326084
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:2326084
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:2326123
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:2326123
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:2326123
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:2326123
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:2326123
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:70792
G Prmt1 protein arginine methyltransferase 1 JBrowse link 1 100,971,132 100,980,411 RGD:2326123
G St13 ST13, Hsp70 interacting protein JBrowse link 7 122,585,770 122,635,731 RGD:2326084
G Stip1 stress-induced phosphoprotein 1 JBrowse link 1 222,274,133 222,293,139 RGD:2326084
altered androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAr chaperonesAndrogen receptor chaperones
Functional ClassAr coactivatorsAndrogen receptor coactivators
Functional ClassAr corepressorsAndrogen receptor corepressors
Gene GroupAr target genesAndrogen receptor target genes
Small MoleculeDHTdihydrotestosterone

Pathway Gene Annotations

Disease Annotations Associated with Genes in the androgen signaling pathway
Disease TermsGene Symbols
Acute Coronary SyndromeHspa8
acute kidney failureAr , Hspa8
Acute Liver FailureHspa8
acute myeloid leukemiaCrebbp , Ncoa2
Acute-Phase ReactionNcor1
adenocarcinomaHspa8 , Ncoa3
adenoid cystic carcinomaCrebbp , Ep300
alopeciaAr
Alzheimer's diseaseCrebbp , Ep300 , Hsp90aa1
amyotrophic lateral sclerosis type 1Crebbp
anaplastic large cell lymphomaHsp90aa1
androgen insensitivity syndromeAr
Androgen Insensitivity Syndrome due to Coactivator DeficiencyAr
anxiety disorderNcor1
asthmaCarm1 , Prmt1
astrocytomaAr , Ncoa3
attention deficit hyperactivity disorderAr , Crebbp
autistic disorderAr , Crebbp
bladder urothelial carcinomaCrebbp , Ep300
Bone NeoplasmsNcoa3
Brain HypoxiaEp300
brain ischemiaHspa8
Breast Cancer, FamilialNcor1
Breast NeoplasmsAr , Carm1 , Ep300 , Hsp90aa1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2
cardiac arrestEp300
CardiomegalyEp300
cardiomyopathyEp300
Castration-Resistant Prostatic NeoplasmsAr
central nervous system diseaseCrebbp
Chemical and Drug Induced Liver InjuryHspa8
clear cell renal cell carcinomaEp300
Cognitive DysfunctionHsp90aa1
colon carcinomaEp300
colorectal cancerEp300
Colorectal NeoplasmsCrebbp , Ep300 , Hspa8
conduct disorderAr
congestive heart failureEp300
contact dermatitisHsp90aa1
coronary artery diseaseAr
Craniofacial AbnormalitiesEp300
cryptorchidismAr
Denys-Drash syndromeAr
Developmental DisabilitiesEp300 , Ncor1
Diabetic NephropathiesEp300 , Hspa8 , Prmt1
diabetic retinopathyEp300
disease of metabolismHspa8
ductal carcinoma in situAr
Endometrial NeoplasmsAr , Ep300 , Ncoa1 , Ncor2
endometriosisAr , Ncoa1 , Ncor1
EndotoxemiaEp300
esophageal carcinomaEp300
Esophageal NeoplasmsEp300
esophagus squamous cell carcinomaCrebbp , Ep300
Experimental Diabetes MellitusAr , Ep300 , Hsp90aa1
Experimental Liver CirrhosisNcor2
Fabry diseaseAr
Familial Prostate CancerAr
Female InfertilityAr , Hsp90ab1
follicular lymphomaCrebbp
Frontotemporal Lobar DegenerationHsp90aa1
gastric adenocarcinomaCrebbp
genetic diseaseAr , Crebbp , Ep300
gestational diabetesAr
glaucomaCrebbp
glioblastoma multiformeCrebbp , Ncor1
glomerulonephritisEp300
Graft vs Host DiseaseHspa8
Gynecomastia, FamilialAr
head and neck squamous cell carcinomaCrebbp , Ep300
heart diseaseEp300
hepatocellular adenomaCarm1
hepatocellular carcinomaAr , Carm1 , Crebbp , Ep300
Hernias, Diaphragmatic, CongenitalEp300
Hirschsprung Disease 1Crebbp
HirsutismEp300
human immunodeficiency virus infectious diseaseHsp90aa1 , Hsp90ab1
Huntington's diseaseCrebbp , Ep300 , Hspa8 , Ncor1
HyperalgesiaEp300
Hyperbilirubinemia, NeonatalNcor1
hypertensionAr , Ep300 , Hspa8
hypogonadismAr
hypospadiasAr
Hypospadias 1, X-LinkedAr
hypothyroidismNcoa1 , Ncor1
inflammatory bowel diseaseHspa8
Insulin ResistanceAr
intellectual disabilityEp300
invasive ductal carcinomaAr
Kennedy's diseaseAr
Kidney Reperfusion InjuryEp300 , Hspa8
Lead Poisoning, Nervous SystemEp300
leiomyomaAr
leukemiaAr , Ncoa3
liver cancerCrebbp
liver diseaseDnaja2
liver neoplasmNcor1
lung adenocarcinomaCrebbp , Ep300
lung small cell carcinomaCrebbp , Ep300
lung squamous cell carcinomaCrebbp , Ep300
macular degenerationHspa8
Male Breast NeoplasmsAr
male infertilityAr
male reproductive system diseaseAr
Mammary Neoplasms, ExperimentalNcoa1
medulloblastomaCrebbp , Ep300
melanomaCrebbp , Ep300 , Stip1
membranoproliferative glomerulonephritisEp300
microcephalyEp300
MicrognathismEp300
Mouth NeoplasmsHspa8
Mullerian AplasiaAr
Multiple AbnormalitiesCrebbp , Ep300
multiple sclerosisHsp90ab1 , Hspa8
Muscle HypotoniaEp300
Muscle SpasticityCrebbp
muscular atrophyHsp90ab1
myelodysplastic syndromeCrebbp
myelofibrosisNcor2
myopiaEp300
Neoplasm MetastasisHsp90aa1 , Ncoa1
Neoplasm Recurrence, LocalAr
nephronophthisis-like nephropathy 1Ep300
Neuropathy, PainfulEp300
non-small cell lung carcinomaNcoa3
obesityAr , Ep300 , Ncoa1 , Ncoa3
Ocular Paraneoplastic SyndromesHspa8
oppositional defiant disorderAr
Optic Nerve InjuriesEp300
osteoarthritisNcor2
Osteoarthritis, KneeAr , Hsp90aa1
osteoporosisAr
Osteoporosis, PostmenopausalAr
Osteoporotic FracturesAr
pancreatitisHsp90ab1
Parkinson's diseaseHspa8
polycystic ovary syndromeAr , Ncor1
portal hypertensionHsp90aa1
precursor lymphoblastic lymphoma/leukemiaCrebbp
Pregnancy ComplicationsNcoa2
prostate adenocarcinomaAr
prostate cancerAr
prostate carcinoma in situAr , Carm1
prostatic hypertrophyAr
Prostatic NeoplasmsAr , Carm1 , Crebbp , Ep300 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2
psoriasisCarm1
pulmonary fibrosisHsp90ab1
relapsing-remitting multiple sclerosisHspa8
renal hypertensionHspa8
Reperfusion InjuryEp300 , Hspa8
RetrognathiaEp300
rheumatoid arthritisHsp90aa1
Rubinstein-Taybi syndromeCrebbp , Ep300
SarcopeniaAr
scoliosisCrebbp
SepsisEp300
Sezary's diseaseCrebbp
spina bifidaCrebbp
Spinal Cord InjuriesHsp90ab1
spinal muscular atrophyAr
spinocerebellar ataxia type 17Hspa8
squamous cell carcinomaCrebbp , Ep300 , Hspa8 , Ncoa3
Stevens-Johnson syndromeEp300
Stomach NeoplasmsHspa8
systemic lupus erythematosusEp300
T-Cell LymphomaEp300
tethered spinal cord syndromeCrebbp
Thumb DeformityCrebbp , Ep300
thyroid hormone resistance syndromeNcoa1
transient cerebral ischemiaEp300 , Hspa8
transitional cell carcinomaCrebbp , Ep300 , Ncor1
type 2 diabetes mellitusAr , Ep300
urinary bladder cancerCrebbp , Ep300 , Ncor1
Uterine Cervical NeoplasmsCrebbp , Ep300 , Hspa8
Pathway Annotations Associated with Genes in the androgen signaling pathway
Pathway TermsGene Symbols
aldosterone signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2
altered androgen signaling pathwayAr , Ncoa2 , Ncor2
androgen signaling pathwayAr , Carm1 , Crebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Hspa8 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Pias2 , Prmt1 , St13 , Stip1
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1 , Hspa8
cell cycle pathway, mitoticCrebbp , Ep300
chaperone mediated autophagy pathwayHsp90aa1 , Hspa8 , St13 , Stip1
clathrin-dependent synaptic vesicle endocytosisHspa8
cortisol signaling pathwayCrebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Stip1
endocytosis pathwayHspa8
Endoplasmic Reticulum-associated degradation pathwayDnaja2 , Hsp90aa1 , Hsp90ab1 , Hspa8
epidermal growth factor/neuregulin signaling pathwayHsp90aa1
estrogen signaling pathwayCarm1 , Crebbp , Dnaja2 , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2 , Prmt1 , Stip1
forkhead class A signaling pathwayAr , Crebbp , Ep300 , Ncoa3
Hedgehog signaling pathwayCrebbp
hepatitis C pathwayPias2
histone modification pathwayCarm1 , Crebbp , Ep300 , Prmt1
homocysteine metabolic pathwayCarm1 , Prmt1
Huntington's disease pathwayCrebbp , Ep300
hypoxia inducible factor pathwayCrebbp , Ep300 , Ncoa1 , Ncoa2
influenza A pathwayCrebbp , Ep300 , Hspa8
Jak-Stat signaling pathwayCrebbp , Ep300 , Pias2
Kennedy's disease pathwayAr
long term potentiationCrebbp , Ep300
measles pathwayHspa8
methionine cycle/metabolic pathwayCarm1 , Prmt1
mitogen activated protein kinase signaling pathwayHspa8
NOD-like receptor signaling pathwayHsp90aa1 , Hsp90ab1
Notch signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Ncoa3
p53 signaling pathwayCrebbp , Ep300
phosphatidylinositol 3-kinase class I signaling pathwayHsp90aa1
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion disease pathwayStip1
prostate cancer pathwayAr , Crebbp , Ep300 , Hsp90aa1 , Hsp90ab1 , Ncoa2 , Ncor2
protein kinase C (PKC) signaling pathwayHsp90aa1
renal cell carcinoma pathwayCrebbp , Ep300
retinoic acid signaling pathwayNcoa1 , Ncoa2 , Ncoa3 , Ncor1 , Ncor2
RNA polymerase I transcription pathwayCrebbp
small cell lung carcinoma pathwayPias2
spliceosome pathwayHspa8
tamoxifen pharmacodynamics pathwayNcoa3 , Ncor1 , Ncor2
toxoplasmosis pathwayHspa8
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300
tuberculosis pathwayCrebbp , Ep300
type II interferon signaling pathwayCrebbp , Ep300
ubiquitin/proteasome degradation pathwayPias2
vascular endothelial growth factor signaling pathwayHsp90aa1 , Hsp90ab1
Wnt signaling pathwayCrebbp , Ep300
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the androgen signaling pathway

References Associated with the androgen signaling pathway:

Ontology Path Diagram:

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