GLYCOGEN DEGRADATION PATHWAY (PW:0000534)

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Description

Glycogenolysis is the degradation pathway of glycogen - a ramified polysaccharide formed by alpha1-4 linked glucose units branching at alpha1-6 bonds - to G6P, a key molecule at the intersection of several pathways of glucose metabolism. In muscle, glycogenolysis is used to provide energy whereas liver glycogenolysis is used to supply glucose to extrahepatic tissues and organs (brain is a good example - it relies on glucose as an energy source while having a limited capacity for storing it

Pathway Diagram:

Ariadne Genomics Inc. G6pc G6pc3 glucose-6-phosphate ---> glycolysis pathway Pp-1 complex ---| Phk complex Phk complex Pp-1 complex Pp-1 complex ---| Pygm Pp-1 complex ---| Pygb Pygb Pp-1 complex ---| Pygl Pygl Pygm Phk complex --+> Pygm Phk complex --+> Pygl Phk complex --+> Pygb gluconeogenesis pathway glycolysis pathway glycogen biosynthetic pathway phosphoglucomutases glucose ---> glucose supply to tissues and organs glucose supply to tissues and organs glucose glucose-6-phosphate ---> glucose gluconeogenesis pathway ---> glucose-6-phosphate glucose-6-phosphate glycogen ---> glucose-1-phosphate glycogen glucose-6-phosphate ---> glycogen glucose-1-phosphate <--> glucose-6-phosphate Agl ---> glycogen Agl glucose-1-phosphate
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Genes in Pathway:

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glycogen degradation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agl amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase JBrowse link 2 219,788,234 219,843,189 RGD:1642741
RGD:2304191
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:2305981
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:2305981
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:2305981
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:1582633
G Pgm1 phosphoglucomutase 1 JBrowse link 5 118,743,632 118,803,055 RGD:2304188
G Pgm2 phosphoglucomutase 2 JBrowse link 14 45,829,440 45,863,883 RGD:2304188
G Pgm3 phosphoglucomutase 3 JBrowse link 8 94,225,513 94,243,230 RGD:2304188
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:2305981
G Phka2 phosphorylase kinase regulatory subunit alpha 2 JBrowse link X 35,970,650 36,926,616 RGD:2305981
G Phkb phosphorylase kinase regulatory subunit beta JBrowse link 19 22,031,684 22,281,788 RGD:2305981
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 JBrowse link 12 30,450,431 30,464,314 RGD:2305981
G Phkg2 phosphorylase kinase catalytic subunit gamma 2 JBrowse link 1 199,019,298 199,032,053 RGD:2305981
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:2304325
RGD:2304267
G Ppp1cb protein phosphatase 1 catalytic subunit beta JBrowse link 6 23,548,507 23,581,136 RGD:2304325
RGD:2304267
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:2304325
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A JBrowse link 4 41,171,486 41,212,116 RGD:2304325
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B JBrowse link 16 60,415,192 60,427,498 RGD:2304325
RGD:2306167
RGD:2304267
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C JBrowse link 1 255,371,830 255,376,833 RGD:2306167
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D JBrowse link 3 173,950,613 173,953,684 RGD:2306167
G Ppp1r3e protein phosphatase 1, regulatory subunit 3E JBrowse link 15 33,535,986 33,537,146 RGD:2306166
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:1642822
RGD:2304109
G Pygl glycogen phosphorylase L JBrowse link 6 92,597,759 92,643,734 RGD:1582633
RGD:2304109
RGD:1642822
RGD:1601233
G Pygm glycogen phosphorylase, muscle associated JBrowse link 1 221,756,325 221,771,142 RGD:1642822
RGD:1599897
RGD:2304109

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classphosphoglucomutasesmembers of the phosphoglucomutase family
ComplexPhk complexphosphorylase kinase complex
ComplexPp-1 complexthe serine/threonine protein phosphatase 1 complex

Pathway Gene Annotations

Disease Annotations Associated with Genes in the glycogen degradation pathway
Disease TermsGene Symbols
adenoid cystic carcinomaPygb
Alzheimer's diseaseCalm1
autistic disorderPhka1 , Phka2 , Phkg1
branched-chain keto acid dehydrogenase kinase deficiencyPhkg2
cannabis abuseCalm1 , Calm2
CardiomegalyPygm
catecholaminergic polymorphic ventricular tachycardiaCalm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
cervical cancerPgm3
Chemical and Drug Induced Liver InjuryPgm1 , Pygl
cholestasisPygm
Cocaine-Related DisordersCalm1 , Calm2
Colorectal NeoplasmsPgm1
congenital disorder of glycosylationPgm1
congestive heart failurePpp1ca , Ppp1cc
Cornelia De Lange Syndrome 5Phka1
diabetes mellitusPpp1r3a
Diabetes Mellitus, Experimental G6pc , Phka1 , Pygm
dilated cardiomyopathyPpp1ca
DwarfismG6pc , Pygb
endometrial cancerPgm1
Experimental Liver CirrhosisAgl , G6pc , Ppp1r3b , Ppp1r3c
familial hypertrophic cardiomyopathyCalm3
Fetal Growth RetardationG6pc
FibrosisPhkg2
genetic diseaseAgl , Calm2 , Phka2 , Pygm
gestational diabetesG6pc
glycogen storage diseasePhka1 , Phka2 , Phkg2 , Pygl , Pygm
glycogen storage disease IG6pc
Glycogen Storage Disease IAG6pc
Glycogen Storage Disease IBG6pc
glycogen storage disease IIIAgl
Glycogen Storage Disease IIIAAgl
Glycogen Storage Disease IIIBAgl
Glycogen Storage Disease IIICAgl
glycogen storage disease IXaPhka2
glycogen storage disease IXbPhkb
glycogen storage disease IXcPhkg2
glycogen storage disease IXdPhka1
glycogen storage disease VPygm
glycogen storage disease VIPygl
Glycogen Storage Disease XIVPgm1
hepatocellular carcinomaPygl
hypoglycemiaG6pc , Ppp1r3a
hypothyroidismPhka1
Immunodeficiency 23Pgm3
Insulin ResistancePpp1r3a
Job's syndromePgm3
liver cirrhosisPhkg2
long QT syndrome 1Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
major depressive disorderCalm2
Malformations of Cortical Development, Group IIPhka2
Mauriac SyndromePhkg2
Multiple AbnormalitiesPhka2
muscular diseasePygm
Myocardial IschemiaPgm1 , Pygb , Pygm
Myocardial Reperfusion InjuryAgl
neuropathyPhka1
Noonan Syndrome-Like Disorder with Loose Anagen Hair 2Ppp1cb
Ovarian NeoplasmsPpp1cc
ParalysisPygm
peripheral nervous system diseasePhka1
phencyclidine abuseCalm1 , Calm2
pleomorphic xanthoastrocytomaPhkg1 , Ppp1r3a
prostate cancerPpp1r3c
Salivary Gland NeoplasmsPygb
Spinal Cord InjuriesPpp1cc
Spinocerebellar Ataxia, X-Linked 1Phka1
teratomaPgm1 , Pgm3
type 2 diabetes mellitusCalm1 , G6pc , Ppp1r3a , Ppp1r3c
uremiaAgl
Weight GainCalm1
Pathway Annotations Associated with Genes in the glycogen degradation pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1r3d
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1
altered galactose metabolic pathwayG6pc
Alzheimer's disease pathwayCalm1 , Calm2 , Calm3
amino sugar metabolic pathwayPgm1 , Pgm3
amiodarone pharmacodynamics pathwayCalm1
amlodipine pharmacodynamics pathwayCalm1
atenolol pharmacodynamics pathwayCalm1
betaxolol pharmacodynamics pathwayCalm1
bisoprolol pharmacodynamics pathwayCalm1
Bone morphogenetic proteins signaling pathwayPpp1ca
bupranolol drug pathwayCalm1
bupranolol pharmacodynamics pathwayCalm1
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
carvedilol pharmacodynamics pathwayCalm1
congenital sucrase-isomaltase deficiency pathwayAgl , Pgm1 , Pygl
diltiazem pharmacodynamics pathwayCalm1
disopyramide pharmacodynamics pathwayCalm1
dobutamine pharmacodynamics pathwayCalm1
dopamine signaling pathwayPpp1ca , Ppp1cb , Ppp1cc
esmolol pharmacodynamics pathwayCalm1
Fanconi syndrome pathwayG6pc
flecainde pharmacodynamics pathwayCalm1
follicle-stimulating hormone signaling pathwayPpp1ca
forkhead class A signaling pathwayG6pc
fosphenytoin pharmacodynamics pathwayCalm1
french type sialuria pathwayPgm3
fructose-1,6-bisphosphatase deficiency pathwayG6pc , Pgm1
galactokinase deficiency pathwayPgm1
galactose metabolic pathwayG6pc , Pgm1
galactosemia pathwayG6pc , Pgm1
GALE deficiency pathwayPgm1
glioma pathwayCalm1 , Calm2 , Calm3
gluconeogenesis pathwayG6pc , Pgm1
Glut1 deficiency syndrome pathwayG6pc
glycogen biosynthetic pathwayPgm1 , Pgm2 , Pgm3 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Ppp1r3e
glycogen degradation pathwayAgl , Calm1 , Calm2 , Calm3 , G6pc , Pgm1 , Pgm2 , Pgm3 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Ppp1r3e , Pygb , Pygl , Pygm
glycogen metabolic pathwayG6pc , Pygl
glycogen storage disease type Ia pathwayG6pc , Pgm1
glycogen storage disease type Ib pathwayG6pc , Pgm1
glycogen storage disease type III pathwayAgl , Pgm1 , Pygl
glycogen storage disease type IV pathwayAgl , Pgm1 , Pygl
glycogen storage disease type VI pathwayAgl , Pgm1 , Pygl
glycogen storage disease type VII pathwayG6pc
glycolysis pathwayG6pc , Pgm1
glycolysis/gluconeogenesis pathwayG6pc , Pgm1
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3
hexosamine biosynthetic pathwayPgm3
histamine signaling pathway, immunologicalPpp1ca
hypoxia inducible factor pathwayPgm1
ibutilide pharmacodynamics pathwayCalm1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCalm1 , Calm2 , Calm3 , Ppp1cc , Ppp1r3a
insulin signaling pathwayCalm1 , Calm2 , Calm3 , G6pc , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Ppp1ca , Ppp1cb , Ppp1cc , Ppp1r3a , Ppp1r3b , Ppp1r3c , Ppp1r3d , Pygb , Pygl , Pygm
isoprenaline pharmacodynamics pathwayCalm1
isradipine pharmacodynamics pathwayCalm1
lactose biosynthetic pathwayG6pc
levobunolol pharmacodynamics pathwayCalm1
lidocaine pharmacodynamics pathwayCalm1
long term potentiationCalm1 , Calm2 , Calm3 , Ppp1ca , Ppp1cb , Ppp1cc
luteinizing hormone signaling pathwayPpp1ca
metoprolol pharmacodynamics pathwayCalm1
mexiletine pharmacodynamics pathwayCalm1
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3
nadolol pharmacodynamics pathwayCalm1
nebivolol pharmacodynamics pathwayCalm1
neurotrophic factor signaling pathwayCalm1 , Calm2 , Calm3
nifedipine pharmacodynamics pathwayCalm1
nimodipine pharmacodynamics pathwayCalm1
nisoldipine pharmacodynamics pathwayCalm1
nitrendipine pharmacodynamics pathwayCalm1
nucleotide sugar metabolic pathwayPgm1 , Pgm3
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3
penbutolol pharmacodynamics pathwayCalm1
pentose phosphate pathwayPgm1
phenytoin pharmacodynamics pathwayCalm1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3
phosphoenolpyruvate carboxykinase deficiency pathwayG6pc , Pgm1
pindolol pharmacodynamics pathwayCalm1
procainamide pharmacodynamics pathwayCalm1
propranolol pharmacodynamics pathwayCalm1
purine metabolic pathwayPgm1
quinidine pharmacodynamics pathwayCalm1
ribose 5-phosphate isomerase deficiency pathwayPgm1
serotonin signaling pathway via receptors engaging G alphas protein familyPpp1ca
sialic acid storage disease pathwayPgm3
sotalol pharmacodynamics pathwayCalm1
starch and sucrose metabolic pathwayAgl , G6pc , Pgm1 , Pygb , Pygl , Pygm
Tay-Sachs disease pathwayPgm3
timolol pharmacodynamics pathwayCalm1
transaldolase deficiency pathwayPgm1
transforming growth factor-beta Smad dependent signaling pathwayPpp1ca
triosephosphate isomerase deficiency pathwayG6pc , Pgm1
tuberculosis pathwayCalm1 , Calm2 , Calm3
type II interferon signaling pathwayCalm1 , Calm2 , Calm3
vascular endothelial growth factor signaling pathwayCalm1 , Calm2 , Calm3
verapamil pharmacodynamics pathwayCalm1
visual phototransduction pathwayCalm1 , Calm2 , Calm3

References Associated with the glycogen degradation pathway:

Ontology Path Diagram:

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