View Ontology Report


Agiotensin II (AgtII) is probably the most potent of the biologically active peptides generated by the renin-angiotensin system pathway. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Of the two receptors, Agtr1, which is expressed in most tissues and which in rodents is represented by two genes that are 95% identical in their amino acid sequences, is the better understood system. The Agtr1 mediated pathway is involved in vas

Pathway Diagram:

Elsevier Inc. Ca2+ calcium/calcium-mediated signaling pathway protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway protein kinase C (PKC) signaling pathway IP3 DAG Gna11 Gnaq G protein mediated signaling pathway via Galphaq family epidermal growth factor/neuregulin signaling pathway EGF transactivation Jak2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway receptor internalization calcium transport pathway renin-angiotensin system signaling pathway Jak-Stat signaling pathway receptor recycling Agtr1 ---- Arrb2 Agtr1 ---- Gnaq Agtr1 ---- Gna11 Agtr1 ---- Jak2 Agtr1b ---- Gnaq Agtr1 ---- Agtrap Agtr1 ---- Arrb1 Agtr1 ---- Arap1 GRK members ---> Agtr1 Agt Agt ---> AgtII AgtII ---- Agtr1 Agtr1b AgtII ---- Agtr1b Agtr1b ---- Gna11 GRK members Arap1 Agtrap ---| Agtr1 Agtr1 Arap1 --+> Agtr1 Rgs2 ---| Gna11 Rgs2 ---| Gnaq Gnaq --+> DAG DAG --+> protein kinase C (PKC) signaling pathway protein kinase C (PKC) signaling pathway ---> epidermal growth factor/neuregulin signaling pathway Rgs2 Arrb2 Arrb1 Agtrap Gnaq --+> IP3 Ca2+ --+> protein kinase C (PKC) signaling pathway IP3 --+> Ca2+ AgtII ---> vasoconstriction vasoconstriction hormone release cell proliferation AgtII ---> cell proliferation AgtII kidney function AgtII ---> kidney function AgtII ---> hormone release

Genes in Pathway:

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angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway
Functional ClassGRKG-protein coupled receptor kinase members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Disease TermsGene Symbols
Abortion, SpontaneousAgtr1a , Jak2
AIDS-Associated NephropathyAgtr1a
albuminuriaAgt , Gnaq
Allanson Pantzar McLeod SyndromeAgt , Agtr1a
Alzheimer DiseaseAgt , Agtr1a , Grk5 , Jak2
Amphetamine-Related DisordersArrb2
AnemiaAgt , Jak2
Aneurysm, DissectingAgt
Angina, UnstableAgt , Agtr1a
ankylosing spondylitisJak2
Anti-Glomerular Basement Membrane DiseaseAgt , Agtr1a
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAgt , Agtr1a
Aortic CalcificationAgt
Aortic CoarctationAgt
Arrhythmias, CardiacAgt , Agtr1a
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2 , Grk2 , Jak2
Arthritis, RheumatoidGrk2 , Grk5 , Grk6 , Jak2 , Tyk2
Atrial FibrillationAgt , Agtr1a
bipolar disorderAgt , Grk3
Blood Coagulation DisordersGnaq
Brain InjuriesJak2
Breast NeoplasmsAgt , Agtr1a , Rgs2
Budd-Chiari SyndromeJak2
Capillary Malformations, CongenitalGnaq
Carcinoma, DuctalAgtr1a
Carcinoma, LobularAgtr1a
Carcinoma, Renal CellAgtr1a
CardiomegalyAgt , Agtr1a , Agtr1b , Agtrap , Gnaq , Grk2 , Grk3
cardiomyopathyAgt , Grk2
Cardiomyopathy, AlcoholicAgt
Cardiomyopathy, HypertrophicAgt
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAgt , Grk2 , Grk5
Carotid Artery DiseasesAgt , Agtr1a
Carotid Artery InjuriesAgtr1a
Cerebrovascular DisordersAgt , Agtr1a
Chronic Intermittent HypoxiaAgt
chronic myeloid leukemiaAgt , Jak2
Chronic Myeloproliferative DisorderJak2
Cocaine-Related DisordersTyk2
Cognition DisordersAgt
Congenital AbnormalitiesGrk2
Corneal NeovascularizationAgt , Agtr1a
Coronary Artery DiseaseAgt , Agtr1a
Coronary DiseaseAgtr1a
Craniofacial AbnormalitiesGna11 , Gnaq
Crohn DiseaseAgt , Jak2 , Tyk2
cutaneous malignant melanoma, susceptibility to, 1Gna11 , Gnaq
Death, SuddenAgt
Depressive Disorder, MajorArrb1
Dermatitis, Allergic ContactGrk2
diabetes mellitus, experimentalAgt
Diabetic NephropathiesAgt , Agtr1a , Jak2
Diabetic RetinopathyAgt , Agtr1a
dilated cardiomyopathyAgt , Agtr1a , Gnaq
Drug OverdoseAgt
Ductus Arteriosus, PatentAgtr1a
Dyskinesia, Drug-InducedGrk6
Embryo LossGrk2
Endomyocardial FibrosisAgt
Epilepsy, Temporal LobeAgt
Erectile DysfunctionAgt
Erythrocytosis, Familial, 1Jak2
Erythrocytosis, Familial, 2Jak2
Experimental Encephalomyelitis, AutoimmuneJak2
Fabry DiseaseAgt
Fatty LiverJak2
Fetal Growth RetardationAgt , Agtr1a
FibrosisAgt , Agtr1a
focal segmental glomerulosclerosisAgt , Agtr1a , Gnaq
Glomerulonephritis, IGAAgt , Agtr1a
Glucose IntoleranceAgtr1a , Jak2
Growth DisordersJak2
Heart Defects, CongenitalGna11 , Gnaq
Heart DiseasesAgt , Jak2
Heart FailureAgt , Agtr1a , Arrb1 , Grk2 , Grk3 , Grk5
Heart Valve DiseasesJak2
Hepatitis, AlcoholicAgt
Hernia, DiaphragmaticAgt , Agtr1a , Agtr1b
Huntington DiseaseAgtr1a
HyperalgesiaAgt , Jak2
HyperinsulinismAgt , Agtr1a
HypertensionAgt , Agtr1a , Agtr1b , Agtrap , Arrb2 , Grk2 , Rgs2
Hypertension, EssentialAgt , Agtr1a
Hypertension, MalignantAgt
Hypertension, Pregnancy-InducedAgt
Hypertension, RenalAgt , Agtr1a
Hypertension, RenovascularAgtr1a , Agtr1b
Hypertensive NephropathyAgt , Agtr1a
Hypertrophy, Left VentricularAgt , Agtr1a , Grk2
Hypocalcemia, Autosomal Dominant 2Gna11
Hypocalciuric Hypercalcemia, Familial, Type 2Gna11
Infarction, Middle Cerebral ArteryAgt
InflammationAgt , Agtr1a , Grk5 , Jak2
Inflammatory Bowel DiseasesAgt
Insulin ResistanceGrk2
Intestinal Reperfusion InjuryJak2
Ischemic Attack, TransientAgt , Jak2
Kidney DiseasesAgt , Agtr1a
Kidney Failure, ChronicAgt
Leukemia, Myeloid, AcuteJak2 , Rgs2
Limb IschemiaAgtr1a
Liver CirrhosisAgt , Arrb1
Liver Cirrhosis, AlcoholicJak2
Liver Cirrhosis, BiliaryAgt , Jak2 , Tyk2
Liver Cirrhosis, ExperimentalAgt , Agtr1a , Arrb2 , Grk2 , Jak2 , Rgs2
Liver DiseasesGrk5
Liver InjuryJak2
Liver Neoplasms, ExperimentalArrb2 , Jak2
Liver Reperfusion InjuryJak2
Lung DiseasesAgtr1a
Lung Diseases, ObstructiveGrk5
Lupus Erythematosus, SystemicJak2
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak2
Mammary Neoplasms, ExperimentalAgt , Agtr1a
Meconium Aspiration SyndromeAgt
MelanomaGna11 , Gnaq
Melanoma, Cutaneous MalignantAgt
Mesenteric Vascular OcclusionJak2
Metabolic Syndrome XAgt , Agtr1a
Mitral Valve ProlapseAgt
Multiple SclerosisAgt , Tyk2
Mycobacterium Infections, NontuberculousTyk2
Myeloproliferative DisordersJak2
Myocardial InfarctionAgt , Agtr1a , Jak2
Myocardial IschemiaAgt , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Arrb2 , Jak2
Neoplasm MetastasisAgtr1a
Nephrosis, Puromycin AminonucleosideAgt
Nephrotic SyndromeJak2
Nevi Flammei, Familial MultipleGnaq
Niemann-Pick Disease, Type CJak2
Non-alcoholic Fatty Liver DiseaseJak2
ObesityAgt , Jak2
ocular melanomaGna11 , Gnaq
pancreatic ductal carcinomaAgtr1a
Paranoid DisordersTyk2
Parkinson DiseaseAgtr1a , Grk2 , Grk3 , Grk5 , Grk6
Parkinson Disease, SecondaryRgs2
Peptic Ulcer HemorrhageAgt
pituitary neoplasmsAgtr1a
Placental InsufficiencyAgtr1a
Polycystic Kidney DiseasesAgt
Polycythemia VeraJak2
Port-Wine StainGnaq
portal hypertensionArrb2 , Grk2
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
Precursor T-Cell Lymphoblastic Leukemia-LymphomaTyk2
prediabetic stateAgt
Pregnancy ComplicationsJak2
Prenatal Exposure Delayed EffectsAgtr1b
Primary MyelofibrosisJak2
Prostatic NeoplasmsJak2
ProteinuriaAgt , Agtr1a
Pulmonary EdemaAgt
Pulmonary FibrosisAgt , Agtr1a
pulmonary hypertensionAgt , Agtr1a
Purpura, Schoenlein-HenochAgt
Radiation Injuries, ExperimentalAgtr1a
Renal FibrosisArrb2
Renal InsufficiencyAgt
Renal Insufficiency, ChronicAgtr1a
Renal Tubular DysgenesisAgt , Agtr1a
Reperfusion InjuryAgt , Jak2
Retinal DetachmentJak2
Retinal VasculitisAgt
Retinopathy of PrematurityAgt
Sciatic NeuropathyAgt
Scleroderma, DiffuseAgt
Scleroderma, LimitedJak2
Scleroderma, SystemicAgt
SepsisGrk2 , Grk5 , Jak2
Sepsis-Associated EncephalopathyJak2
Sick Sinus SyndromeAgt
Spinal Cord InjuriesJak2
Stomach NeoplasmsRgs2
Stomach UlcerAgt
StrokeAgt , Jak2
Sturge-Weber SyndromeGnaq
Temporomandibular Joint DisordersGrk5
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2
Transplant RejectionArrb1 , Arrb2
type 1 diabetes mellitusTyk2
type 2 diabetes mellitusAgt , Arrb2
tyrosine kinase 2 deficiencyTyk2
ulcerative colitisJak2
ureteral obstructionAgt
uterine cervical neoplasmsJak2
Uveal MelanomaGna11 , Gnaq
Vascular RemodelingAgt
Vascular System InjuriesAgtr1a , Grk2
Venous ThrombosisJak2
Ventricular Dysfunction, LeftAgt
Ventricular RemodelingAgtr1a
Vesico-Ureteral RefluxAgtr1a
Water-Electrolyte ImbalanceAgtr1b
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5 , Rgs2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGna11 , Gnaq
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2
altered Jak-Stat signaling pathwayJak2
Alzheimer disease pathwayGnaq
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Agtrap , Arap1 , Arrb1 , Arrb2 , Gna11 , Gnaq , Grk2 , Grk3 , Grk5 , Grk6 , Jak2 , Rgs2 , Tyk2
angiotensin II signaling pathway via AT2 receptorAgt
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAgt , Agtr1a
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b , Gna11 , Gnaq
candesartan pharmacodynamics pathwayAgt , Agtr1a
captopril pharmacodynamics pathwayAgt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Jak2
cilazapril pharmacodynamics pathwayAgt , Agtr1a
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Grk3 , Grk6
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
eicosanoid signaling pathwayArrb2 , Gna11 , Gnaq , Grk2 , Grk3
enalapril pharmacodynamics pathwayAgt , Agtr1a
endocytosis pathwayArap1 , Arrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6
endothelin signaling pathwayGna11 , Gnaq , Jak2
Entamoeba histolyca infection pathwayGna11 , Gnaq
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2 , Grk5
eprosartan pharmacodynamics pathwayAgt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAgt , Agtr1a
fosinopril pharmacodynamics pathwayAgt , Agtr1a
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathwayGrk2 , Grk3
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyRgs2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b , Gna11 , Gnaq , Rgs2
G protein mediated signaling pathway via Galphas familyGrk2 , Grk3 , Rgs2
glutamate signaling pathwayGnaq , Grk2 , Grk3
gonadotropin-releasing hormone signaling pathwayGna11 , Gnaq
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2
growth hormone signaling pathwayJak2
Hedgehog signaling pathwayArrb2 , Grk2
Huntington disease pathwayGnaq
ibutilide pharmacodynamics pathwayAgtr1a
influenza A virus infection pathwayJak2
Interleukin-10 signaling pathwayTyk2
interleukin-12 signaling pathwayJak2 , Tyk2
interleukin-23 signaling pathwayJak2 , Tyk2
interleukin-27 signaling pathwayJak2 , Tyk2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2 , Tyk2
irbesartan pharmacodynamics pathwayAgt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2 , Tyk2
kinin signaling pathwayArrb1 , Arrb2
Leishmania infection pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAgt , Agtr1a
long term depressionGna11 , Gnaq
long term potentiationAgt , Gnaq
losartan pharmacodynamics pathwayAgt , Agtr1a
measles infection pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
moexipril pharmacodynamics pathwayAgt , Agtr1a
Mycobacterium tuberculosis infection pathwayJak2
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
Non-Stat, Jak dependent pathwayTyk2
nuclear factor kappa B signaling pathwayArrb2
olmesartan pharmacodynamics pathwayAgt , Agtr1a
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxytocin signaling pathwayGna11 , Gnaq
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAgt , Agtr1a
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayArap1 , Jak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAgt , Agtr1a
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAgt , Agtr1a
renin-angiotensin cascade pathwayAgt , Agtr1a , Agtr1b
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayGna11 , Gnaq , Jak2
spirapril pharmacodynamics pathwayAgt , Agtr1a
telmisartan pharmacodynamics pathwayAgt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
Toxoplasma gondii infection pathwayJak2
trandolapril pharmacodynamics pathwayAgt , Agtr1a
transforming growth factor-beta Smad dependent signaling pathwayArrb2
Trypanosoma brucei infection pathwayGnaq
Trypanosoma cruzi infection pathwayGna11 , Gnaq
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAgt , Agtr1a
vasopressin signaling pathwayGna11 , Gnaq
vasopressin signaling pathway via receptor type 1Gna11 , Gnaq
verapamil pharmacodynamics pathwayAgtr1a
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor

References Associated with the angiotensin II signaling pathway via AT1 receptor:

Ontology Path Diagram:

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