View Ontology Report


Agiotensin II (AgtII) is probably the most potent of the biologically active peptides generated by the renin-angiotensin system pathway. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Of the two receptors, Agtr1, which is expressed in most tissues and which in rodents is represented by two genes that are 95% identical in their amino acid sequences, is the better understood system. The Agtr1 mediated pathway is involved in vas

Pathway Diagram:

Elsevier Inc. Ca2+ calcium/calcium-mediated signaling pathway protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway protein kinase C (PKC) signaling pathway IP3 DAG Gna11 Gnaq G protein mediated signaling pathway via Galphaq family epidermal growth factor/neuregulin signaling pathway EGF transactivation Jak2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway receptor internalization calcium transport pathway renin-angiotensin system signaling pathway Jak-Stat signaling pathway receptor recycling Agtr1 ---- Arrb2 Agtr1 ---- Gnaq Agtr1 ---- Gna11 Agtr1 ---- Jak2 Agtr1b ---- Gnaq Agtr1 ---- Agtrap Agtr1 ---- Arrb1 Agtr1 ---- Arap1 GRK members ---> Agtr1 Agt Agt ---> AgtII AgtII ---- Agtr1 Agtr1b AgtII ---- Agtr1b Agtr1b ---- Gna11 GRK members Arap1 Agtrap ---| Agtr1 Agtr1 Arap1 --+> Agtr1 Rgs2 ---| Gna11 Rgs2 ---| Gnaq Gnaq --+> DAG DAG --+> protein kinase C (PKC) signaling pathway protein kinase C (PKC) signaling pathway ---> epidermal growth factor/neuregulin signaling pathway Rgs2 Arrb2 Arrb1 Agtrap Gnaq --+> IP3 Ca2+ --+> protein kinase C (PKC) signaling pathway IP3 --+> Ca2+ AgtII ---> vasoconstriction vasoconstriction hormone release cell proliferation AgtII ---> cell proliferation AgtII kidney function AgtII ---> kidney function AgtII ---> hormone release

Genes in Pathway:

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angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway
Functional ClassGRKG-protein coupled receptor kinase members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Disease TermsGene Symbols
abdominal aortic aneurysmAgt , Agtr1a
Abortion, SpontaneousAgtr1a , Jak2
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak2
acute myeloid leukemiaJak2 , Rgs2
AIDS-Associated NephropathyAgtr1a
AlbuminuriaAgt , Gnaq
alcoholic cardiomyopathyAgt
alcoholic hepatitisAgt
alcoholic liver cirrhosisJak2
Allanson Pantzar McLeod SyndromeAgt , Agtr1a
allergic contact dermatitisGrk2
allergic hypersensitivity diseaseAgt
Alzheimer's diseaseAgt , Agtr1a , Grk5 , Jak2
amphetamine abuseArrb2
anemiaAgt , Jak2
ankylosing spondylitisJak2
anti-basement membrane glomerulonephritisAgt , Agtr1a
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAgt
Arteriovenous FistulaArrb1 , Arrb2
atrial fibrillationAgt , Agtr1a
autosomal dominant hypocalcemia 2Gna11
bipolar disorderAgt , Grk3
bladder diseaseRgs2
blood coagulation diseaseGnaq
Brain InjuriesJak2
breast cancerAgt , Agtr1a
Breast NeoplasmsRgs2
Budd-Chiari syndromeJak2
Cardiac ArrhythmiasAgt , Agtr1a
CardiomegalyAgt , Agtr1a , Agtr1b , Agtrap , Gnaq , Grk2 , Grk3
cardiomyopathyAgt , Grk2
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAgt , Grk2 , Grk5
carotid artery diseaseAgt , Agtr1a
Carotid Artery InjuriesAgtr1a
cerebrovascular diseaseAgt , Agtr1a
Chronic Intermittent HypoxiaAgt
chronic kidney diseaseAgtr1a
chronic myeloid leukemiaAgt , Jak2
Cocaine-Related DisordersGrk2 , Grk3 , Grk5 , Tyk2
cognitive disorderAgt
Congenital AbnormalitiesGrk2
Congenital Capillary MalformationsGnaq
congenital heart diseaseGna11 , Gnaq
congestive heart failureAgt , Agtr1a , Arrb1 , Gnaq , Grk2 , Grk3 , Grk5
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAgt , Agtr1a
Coronary DiseaseAgtr1a
Craniofacial AbnormalitiesGna11 , Gnaq
Crohn's diseaseAgt , Jak2 , Tyk2
Diabetes Mellitus, Experimental Agt
Diabetic NephropathiesAgt , Agtr1a , Grk2 , Grk3 , Grk6 , Jak2
diabetic retinopathyAgt , Agtr1a
Diaphragmatic HerniaAgt , Agtr1a , Agtr1b
diffuse sclerodermaAgt
dilated cardiomyopathyAgt , Agtr1a , Gnaq
Dissecting AneurysmAgt
Drug OverdoseAgt
Drug-Induced DyskinesiaGrk6
Ductal CarcinomaAgtr1a
Embryo LossGrk2
end stage renal failureAgt
endomyocardial fibrosisAgt
essential hypertensionAgt , Agtr1a
essential thrombocythemiaJak2
Experimental ArthritisArrb1 , Arrb2 , Grk2 , Jak2
Experimental Autoimmune EncephalomyelitisJak2
Experimental Autoimmune MyocarditisGrk2
Experimental Liver CirrhosisAgt , Agtr1a , Arrb2 , Grk2 , Jak2 , Rgs2
Experimental Liver NeoplasmsArrb2 , Jak2
Fabry diseaseAgt
familial erythrocytosis 1Jak2
familial erythrocytosis 2Jak2
familial hypocalciuric hypercalcemia 2Gna11
Familial Multiple Nevi FlammeiGnaq
fatty liver diseaseJak2
female stress incontinenceRgs2
Fetal Growth RetardationAgt , Agtr1a
FibrosisAgt , Agtr1a
focal segmental glomerulosclerosisAgt , Agtr1a , Gnaq
gastric ulcerAgt
glomerulosclerosisAgtr1a , Rgs2
glucose intoleranceAgt , Agtr1a , Jak2
Growth DisordersJak2
heart diseaseAgt , Jak2
heart valve diseaseJak2
Henoch-Schoenlein purpuraAgt
Huntington's diseaseAgtr1a
HyperalgesiaAgt , Grk2 , Jak2
hyperinsulinismAgt , Agtr1a
Hyperparathyroidism 1Rgs2
hypertensionAgt , Agtr1a , Agtr1b , Agtrap , Arrb2 , Grk2 , Grk3 , Grk5 , Rgs2
Hypertension, Pregnancy-InducedAgt
Hypertensive NephropathyAgt , Agtr1a
hypertrophic cardiomyopathyAgt
IgA glomerulonephritisAgt , Agtr1a
impotenceAgt , Grk2
InflammationAgt , Agtr1a , Grk5 , Jak2
inflammatory bowel diseaseAgt
Insulin ResistanceGrk2
intermediate coronary syndromeAgt , Agtr1a
Intestinal Reperfusion InjuryAgt , Jak2
invasive lobular carcinomaAgtr1a
kidney diseaseAgt , Agtr1a
kidney failureAgt
Left Ventricular HypertrophyAgt , Agtr1a , Grk2
Limb IschemiaAgtr1a , Grk2
limited sclerodermaJak2
liver cirrhosisAgt , Arrb1 , Grk2 , Rgs2
liver diseaseGrk5
Liver InjuryJak2
Liver Reperfusion InjuryJak2
lung diseaseAgtr1a
major depressive disorderArrb1
malignant hypertensionAgt
Mammary Neoplasms, ExperimentalAgt , Agtr1a
meconium aspiration syndromeAgt
melanomaGna11 , Gnaq
mesenteric vascular occlusionJak2
Metabolic SyndromeAgt , Agtr1a
middle cerebral artery infarctionAgt
mitral valve prolapseAgt
multiple sclerosisAgt , Tyk2
myeloid neoplasmJak2
myeloproliferative neoplasmJak2
myocardial infarctionAgt , Agtr1a , Jak2
Myocardial IschemiaAgt , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Arrb2 , Grk2 , Jak2
Neoplasm MetastasisAgtr1a
Nephrosis, Puromycin AminonucleosideAgt
nephrotic syndromeJak2
Niemann-Pick disease type C1Jak2
nonalcoholic fatty liver diseaseJak2
Nontuberculous Mycobacterium InfectionsTyk2
obesityAgt , Jak2 , Tyk2
obstructive lung diseaseGrk5
ocular melanomaGna11 , Gnaq
opioid abuseRgs2
pancreatic ductal carcinomaAgtr1a
Paranoid DisordersTyk2
Parkinson's diseaseAgtr1a , Grk2 , Grk3 , Grk5 , Grk6
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
pituitary adenomaGrk2
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
polycystic kidney diseaseAgt
polycythemia veraJak2
Port-Wine StainGnaq
portal hypertensionArrb2 , Grk2
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
precursor T-lymphoblastic lymphoma/leukemiaTyk2
prediabetes syndromeAgt
Pregnancy ComplicationsJak2
Prenatal Exposure Delayed EffectsAgtr1b
primary biliary cirrhosisAgt , Jak2 , Tyk2
Prostatic NeoplasmsJak2
proteinuriaAgt , Agtr1a
pulmonary edemaAgt
pulmonary fibrosisAgt , Agtr1a
pulmonary hypertensionAgt , Agtr1a
Radiation Injuries, ExperimentalAgtr1a
renal cell carcinomaAgtr1a
renal fibrosisArrb2
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAgt , Agtr1a
renovascular hypertensionAgtr1a , Agtr1b
Reperfusion InjuryAgt , Jak2
retinal detachmentJak2
retinal vasculitisAgt
retinopathy of prematurityAgt
rheumatoid arthritisGrk2 , Grk5 , Grk6 , Jak2 , Tyk2
Right Ventricular HypertrophyGrk2
sciatic neuropathyAgt
secondary Parkinson diseaseRgs2
SepsisGrk2 , Grk5 , Jak2
Sepsis-Associated EncephalopathyJak2
sick sinus syndromeAgt
skin melanomaAgt , Gna11 , Gnaq
Spinal Cord InjuriesGrk6 , Jak2
Stomach NeoplasmsRgs2
StrokeAgt , Jak2
Sturge-Weber SyndromeGnaq
Sudden DeathAgt
systemic lupus erythematosusJak2
systemic sclerodermaAgt
temporal lobe epilepsyAgt
Temporomandibular Joint DisordersGrk5
Thrombocythemia 3Jak2
transient cerebral ischemiaAgt , Jak2
Transplant RejectionArrb1 , Arrb2
type 1 diabetes mellitusTyk2
type 2 diabetes mellitusAgt , Arrb2
Tyrosine Kinase 2 DeficiencyTyk2
ulcerative colitisJak2
ureteral obstructionAgt
Uterine Cervical NeoplasmsJak2
uveal melanomaGna11 , Gnaq
Vascular RemodelingAgt
Vascular System InjuriesAgtr1a , Grk2
Venous ThrombosisJak2
Ventricular Dysfunction, LeftAgt
Ventricular RemodelingAgtr1a
vesicoureteral refluxAgtr1a
visual epilepsyAgt
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Grk5 , Rgs2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGna11 , Gnaq
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2
altered Jak-Stat signaling pathwayJak2
Alzheimer's disease pathwayGnaq
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Agtrap , Arap1 , Arrb1 , Arrb2 , Gna11 , Gnaq , Grk2 , Grk3 , Grk5 , Grk6 , Jak2 , Rgs2 , Tyk2
angiotensin II signaling pathway via AT2 receptorAgt
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAgt , Agtr1a
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b , Gna11 , Gnaq
candesartan pharmacodynamics pathwayAgt , Agtr1a
captopril pharmacodynamics pathwayAgt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
Chagas disease pathwayGna11 , Gnaq
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Jak2
cilazapril pharmacodynamics pathwayAgt , Agtr1a
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Grk3 , Grk6
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6 , Rgs2
eicosanoid signaling pathwayArrb2 , Gna11 , Gnaq , Grk2 , Grk3
enalapril pharmacodynamics pathwayAgt , Agtr1a
endocytosis pathwayArap1 , Arrb1 , Arrb2 , Grk2 , Grk3 , Grk5 , Grk6
endothelin signaling pathwayGna11 , Gnaq , Jak2
Entamoebiasis pathwayGna11 , Gnaq
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2 , Grk5
eprosartan pharmacodynamics pathwayAgt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAgt , Agtr1a
fosinopril pharmacodynamics pathwayAgt , Agtr1a
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathwayGrk2 , Grk3
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyRgs2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b , Gna11 , Gnaq , Rgs2
G protein mediated signaling pathway via Galphas familyGrk2 , Grk3 , Rgs2
glutamate signaling pathwayGnaq , Grk2 , Grk3
gonadotropin-releasing hormone signaling pathwayGna11 , Gnaq
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2
growth hormone signaling pathwayJak2
Hedgehog signaling pathwayArrb2 , Grk2
Huntington's disease pathwayGnaq
ibutilide pharmacodynamics pathwayAgtr1a
influenza A pathwayJak2
Interleukin-10 signaling pathwayTyk2
interleukin-12 signaling pathwayJak2 , Tyk2
interleukin-23 signaling pathwayJak2 , Tyk2
interleukin-27 signaling pathwayJak2 , Tyk2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2 , Tyk2
irbesartan pharmacodynamics pathwayAgt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2 , Tyk2
kinin signaling pathwayArrb1 , Arrb2
Leishmaniasis pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAgt , Agtr1a
long term depressionGna11 , Gnaq
long term potentiationAgt , Gnaq
losartan pharmacodynamics pathwayAgt , Agtr1a
measles pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2
moexipril pharmacodynamics pathwayAgt , Agtr1a
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
Non-Stat, Jak dependent pathwayTyk2
nuclear factor kappa B signaling pathwayArrb2
olmesartan pharmacodynamics pathwayAgt , Agtr1a
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxytocin signaling pathwayGna11 , Gnaq
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAgt , Agtr1a
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayArap1 , Jak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAgt , Agtr1a
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAgt , Agtr1a
renin-angiotensin cascade pathwayAgt , Agtr1a , Agtr1b
sleeping sickness pathwayGnaq
somatostatin signaling pathwayGrk2 , Jak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayGna11 , Gnaq , Jak2
spirapril pharmacodynamics pathwayAgt , Agtr1a
telmisartan pharmacodynamics pathwayAgt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
toxoplasmosis pathwayJak2
trandolapril pharmacodynamics pathwayAgt , Agtr1a
transforming growth factor-beta Smad dependent signaling pathwayArrb2
tuberculosis pathwayJak2
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAgt , Agtr1a
vasopressin signaling pathwayGna11 , Gnaq
vasopressin signaling pathway via receptor type 1Gna11 , Gnaq
verapamil pharmacodynamics pathwayAgtr1a
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling, non-canonical pathwayArrb2
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT1 receptor

References Associated with the angiotensin II signaling pathway via AT1 receptor:

Ontology Path Diagram:

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