NUCLEAR FACTOR KAPPA B SIGNALING PATHWAY (PW:0000499)

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Description

Nuclear Factor kappa B (NF-kB) signaling pathway is essential for the proper functioning of the immune system. NF-kB pathway regulates the expression of cytokines, growth factors and other regulatory proteins; its signaling is set in motion in response to the activation of upstream pathways. Tumor necrosis factor (Tnf) alpha via tumor necrosis receptor R1, interleukin-1 via interleukin receptor 1 and lipopolysaccharide (LPS) triggered Toll-like receptors pathways converge on the activation of th

Pathway Diagram:

Elsevier Inc. Nfkb2 RELB K63-ubiquitin M1-Ubiquitin M1-ubiquitination miRNA in NF-kB LUBAC complex SCF ubiquitin ligase complex K63-polyubiquitination NF-kB target genes Tnf receptor superfamily, other upstream activators adapters adapters ---- Ikbkg adapters --+> Map3k14 SCF ubiquitin ligase complex ---| Nfkbia Rel Map3k14 --+> Chuk Chuk Map3k14 Ikbkb ---> Nfkbia Ikbkb ---> Nfkbib Ikbkb ---> Nfkbie Nfkbia Ikbkb Nfkbib K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Ikbkg ---- K63-ubiquitin Ikbkg Map3k7 Nfkbie Ikbkb ---- Ikbkg Ikbkg ---- M1-Ubiquitin Nfkbia ---- Rela Nfkbia ---| Rela Nfkb1 ---- Nfkbia Nfkbib ---- Rela Nfkbib ---| Rela Chuk ---- Ikbkg SCF ubiquitin ligase complex ---| Nfkbib SCF ubiquitin ligase complex ---| Nfkbie Chuk ---- Ikbkb Chuk --+> Nfkb2 NF-kB target genes ---> Nfkbia Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb1 ---> NF-kB target genes Rel ---> NF-kB target genes Rela ---> NF-kB target genes Nfkb2 ---> NF-kB target genes RELB ---> NF-kB target genes miRNA in NF-kB ---> NF-kB target genes NF-kB target genes ---> miRNA in NF-kB Rela Nfkb1 Map3k7 --+> Ikbkb LUBAC complex ---> Ikbkg Cyld Tab2 Tab3 Tab1 Cyld ---| K63-polyubiquitination adapters --+> Map3k7 Cyld ---| Map3k7
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Genes in Pathway:

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nuclear factor kappa B signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bcl10 B-cell CLL/lymphoma 10 JBrowse link 2 251,805,392 251,814,957 RGD:6484113
G Bcl3 B-cell CLL/lymphoma 3 JBrowse link 1 80,730,758 80,745,273 RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5490225
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292172
RGD:6484113
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6484113
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:6484113
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:6484113
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:5490225
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800735
RGD:7800734
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292172
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292172
RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6484113
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:6484113
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:2292172
RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490225
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:2292172
RGD:6484113
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:2292172
RGD:6484113
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:2292172
RGD:6484113
G Nfkbib NFKB inhibitor beta JBrowse link 1 86,941,073 86,948,845 RGD:2292172
G Nfkbie NFKB inhibitor epsilon JBrowse link 9 17,828,405 17,835,240 RGD:2292172
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6484113
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:5490225
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:2292172
RGD:6484113
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:2292172
RGD:6484113
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6484113
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:6484113
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:5490225
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490225
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490225
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6484113
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:6484113
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupmiRNA in NF-kB
Gene GroupNF-kB target geneslink to a comprehensive list of NF-kB targets and website
ComplexLUBAC complexM1-ubiqutin
ComplexSCF ubiquitin ligase complextargets Nf-kB inhibitory proteins for degradation

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Disease TermsGene Symbols
acneTnf , Tnfrsf1a
acquired immunodeficiency syndromeTnf , Tnfrsf1a
Acute Coronary SyndromeTnf
acute kidney failureNfkb1 , Tnf , Tnfrsf1a
Acute Liver FailureAtm , Tnf
Acute Lung InjuryNod2 , Tnf
acute T cell leukemiaBcl10
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaNfkb1 , Pik3ca , Tnf
adenoid cystic carcinomaAtm , Pik3ca
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adult respiratory distress syndromeTnf , Tnfrsf1a
adult T-cell leukemiaCsnk2a1 , Csnk2b
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AlbuminuriaTnf
alcoholic hepatitisTnf
alcoholic liver cirrhosisRela , Tnf
allergic bronchopulmonary aspergillosisTnf , Tnfrsf1a
allergic conjunctivitisIrf1 , Lck
allergic contact dermatitisTnf
allergic hypersensitivity diseaseTnf , Tnfrsf1a
allergic rhinitisNod2
Alveolar Bone LossTnf
Alzheimer's diseaseAtm , Ikbkb , Mapk14 , Pik3r1 , Tnf
amphetamine abuseArrb2 , Rela
amyloidosisTnf , Tnfrsf1a
amyotrophic lateral sclerosisMapk14 , Tnf
amyotrophic lateral sclerosis type 1Tnf
anemiaTnf , Tnfrsf1a
Anemia, RefractoryTnf
Angina, StableTnf
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsTnf
AnorexiaTnf , Tnfrsf1a
anterior uveitisTnf
anthracosisTnf
anti-basement membrane glomerulonephritisMapk14 , Syk , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf , Tnfrsf1a
anxiety disorderTnf
aplastic anemiaTnf
Arsenic PoisoningTnf
arteriosclerosisAtm , Rela , Tnfrsf1a
Arteriovenous FistulaArrb2
asbestosisTnf
aspiration pneumoniaTnf
asthmaChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
Asthma, OccupationalPrkca , Tnf
ataxia telangiectasiaAtm
Ataxia-Telangiectasia VariantAtm
atherosclerosisNod2 , Tnf
atopic dermatitisNfkbia , Relb , Sharpin , Tnf
atrial fibrillationTnf
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autistic disorderTnf
Autoimmune DiseasesNod2 , Tnfrsf1a
autoimmune thyroiditisTnf
autosomal dominant familial periodic feverTnfrsf1a
autosomal recessive polycystic kidney diseasePik3ca , Src
autosomal recessive pseudohypoaldosteronism type 1Tnfrsf1a
B-cell lymphomaAtm
BacteremiaNod2
bacterial infectious diseaseNod2
bacterial pneumoniaChuk , Irf1 , Nod2 , Tnf , Tnfrsf1a
Bannayan-Riley-Ruvalcaba syndromePik3ca
Barrett's esophagusRela
basal cell carcinomaPik3ca
Behcet's diseaseIkbkg , Nod2 , Tnf , Tnfrsf1a
berylliosisTnf
beta thalassemiaTnf
bilateral breast cancerAtm
bilirubin metabolic disorderTnf
bladder urothelial carcinomaPik3ca
Blau syndromeNod2
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
brain edemaTnf
Brain InjuriesIrf1 , Rela , Tnf , Tnfrsf1a
brain ischemiaNfkb1 , Nfkbia , Prkca , Rela , Src , Tnf , Tnfrsf1a
Brain NeoplasmsPik3ca , Pik3r1 , Rela
breast adenocarcinomaPik3ca
breast cancerAtm , Nfkb1 , Pik3ca , Xpo1
Breast Cancer, FamilialAtm
Breast NeoplasmsAtm , Birc2 , Csnk2a1 , Ikbkb , Nfkbia , Nod2 , Pik3ca , Pik3r1 , Prkca , Rel , Rela , Relb , Src , Tnf , Xpo1
Bronchial HyperreactivityTnf
bronchiectasisTnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
bronchiolitis obliteransNod2
Bronchopulmonary DysplasiaTnf
Brooke-Spiegler syndromeCyld
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsTnf
CachexiaTnf , Tnfrsf1a
carcinomaPik3r1 , Ran
cardiac arrestTnf
Cardiac FibrosisNfkbia
CardiomegalyPrkca , Rbck1 , Rela , Src , Tnf
cardiomyopathyMapk14 , Tnf
Cardiovirus InfectionsTnf
cataractAtm
Cell Transformation, NeoplasticNfkb1 , Rela
cerebellar ataxiaAtm
Cerebral HemorrhageNfkb1 , Nfkb2 , Nfkbia , Rela , Relb
cerebral infarctionTnf
cervix uteri carcinoma in situRela
Chemical and Drug Induced Liver InjuryTnf
Childhood SchizophreniaRela
chlamydiaTnf
cholestasisMapk14 , Rela , Tnf
cholesteatoma of middle earRela , Tnf
chorioamnionitisTnf
Choroidal NeovascularizationIkbkb
Chronic Allograft DysfunctionTnf
Chronic Cerebral HypoperfusionMapk14
chronic lymphocytic leukemiaXpo1
Chronic Lymphocytic Leukemia, B-CellAtm , Tnf , Xpo1
chronic myeloid leukemiaMapk14
chronic obstructive pulmonary diseaseNod2 , Tnf , Tnfrsf1a
cicatricial pemphigoidTnf
cleft palateChuk
cocoon syndromeChuk
Cognition DisordersMapk14
colitisChuk , Ikbkb , Nod2 , Rela , Src , Tnf
colon cancerBcl10 , Pik3ca , Src
colon carcinomaBcl10 , Pik3ca
Colonic NeoplasmsIkbkb , Nfkb1 , Nod2 , Pik3ca , Pik3r1 , Rela , Src , Tnf , Tnfrsf1a
colorectal adenomaTnfrsf1a
colorectal cancerBcl10 , Pik3ca , Src
Colorectal NeoplasmsBcl10 , Pik3ca , Pik3r1 , Src , Tnf , Xpo1
common variable immunodeficiencyNfkb1 , Nfkb2
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsPik3ca
congenital diaphragmatic herniaTnf
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Limb DeformitiesChuk
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congestive heart failurePrkca , Tnf , Tnfrsf1a
Cor pulmonaleTnf
corneal ulcerTnf
coronary artery diseaseNod2 , Tnf , Tnfrsf1a , Traf6
coronary restenosisTnf
CoughTnf
Cowden diseasePik3ca
Cowden Syndrome 5Pik3ca
Cowden-Like SyndromePik3ca
Coxsackievirus InfectionsTnf
Crohn's diseaseNod2 , Tnf , Tnfrsf1a
cryoglobulinemiaTnf
cryptogenic organizing pneumoniaTnfrsf1a
cryptorchidismNfkbia , Rela
Currarino TriadPik3ca
cutaneous leishmaniasisTnf
Cutaneous Malignant Melanoma, Susceptibility To, 1Pik3ca
cutaneous T cell lymphomaAtm , Nfkb2
cystic fibrosisIrf1 , Tnf , Tnfrsf1a
cystitisRela , Tnf
Cytomegalovirus InfectionsTnf
cytomegalovirus retinitisTnf , Tnfrsf1a
demyelinating diseaseTnf
dermatitisIkbkb , Nod2 , Sharpin , Tnf
dermatitis herpetiformisTnf
dermatomyositisTnf
diabetic angiopathyRela , Tnf
Diabetic CardiomyopathiesTnf
Diabetic NephropathiesMapk14 , Rela , Tnf , Tnfrsf1a
diabetic neuropathyMapk14 , Tnf
diabetic retinopathyTnf
diffuse large B-cell lymphomaMalt1 , Nfkbia , Pik3ca
dilated cardiomyopathyAtm , Lck , Prkca , Tnf
dilated cardiomyopathy 1HTnf
disease by infectious agentTnf
disease of cellular proliferationAtm , Pik3ca , Pik3r1 , Src
Disease ProgressionPik3ca
disseminated intravascular coagulationTnf
drug allergyTnf
Drug-Induced DyskinesiaRela
dry eye syndromeTnf
ductal carcinoma in situPrkca , Rela , Src
Eales DiseaseTnf
Early-Onset SarcoidosisNod2
Ectodermal Dysplasia, Anhidrotic, with T-Cell Immunodeficiency, Autosomal DominantNfkbia
EdemaTnf
EmphysemaTnf
encephalitisNfkbia , Rela , Tnf
encephalomyelitisTnf
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg
End Stage Liver DiseaseTnfrsf1a
end stage renal failureNfkb1 , Rela , Tnf , Tnfrsf1a
endometrial cancerPik3r1
endometrial carcinomaPik3ca , Pik3r1
Endometrial NeoplasmsAtm , Irf1 , Pik3ca , Prkca , Tnfrsf1a
endometriosisNfkbia , Tnf
endophthalmitisTnf
EndotoxemiaMapk14 , Tnf
Enterovirus InfectionsTnfrsf1a
EosinophiliaSharpin
epidermal nevusPik3ca
epilepsyRela , Tnf
Erythema NodosumTnf
esophageal carcinomaPik3ca
Esophageal NeoplasmsPik3ca
esophagitisTnf
esophagus adenocarcinomaPik3ca
Experimental ArthritisArrb2 , Ikbkb , Ikbkg , Nod2 , Tnf , Tnfrsf1a
Experimental Autoimmune EncephalomyelitisTnf
Experimental Autoimmune NeuritisTnf
Experimental Autoimmune UveoretinitisTnfrsf1a
Experimental ColitisNfkbia , Nod2 , Tnf , Tnfrsf1a
Experimental Diabetes MellitusIkbkb , Nfkb2 , Nfkbia , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a
Experimental Liver CirrhosisArrb2 , Nfkbia , Nfkbie , Rela , Tnf
Experimental NeoplasmsRela , Tnf
extrahepatic cholestasisMap3k7 , Rela , Tnf
extrinsic allergic alveolitisTnf , Tnfrsf1a
eye diseaseTnf
Facial AsymmetryPik3ca
familial Mediterranean feverNod2 , Tnfrsf1a
Fanconi anemiaTnf
farmer's lungTnf
fatty liver diseaseIkbkg , Nfkb1 , Rela , Tnf
Fetal DiseasesChuk
FeverTnf , Tnfrsf1a
Fibromatosis, AggressiveTnf
fibrosarcomaTnfrsf1a
FibrosisAtm , Tnf
focal segmental glomerulosclerosisTnf , Tnfrsf1a
follicular lymphomaBcl10
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
Fungal Lung DiseasesTnf
gastric adenocarcinomaPik3ca
gastric ulcerTnf
gastritisNfkbia , Nod2 , Tnf
Gastrointestinal NeoplasmsPik3ca
Gaucher's diseaseTnf
genetic diseaseAtm , Csnk2a1 , Csnk2b , Ikbkg , Nod2 , Pik3ca , Pik3r1 , Tnfrsf1a
glaucomaTnf
glioblastoma multiformePik3ca , Pik3r1
glomerulonephritisTnf , Tnfrsf1a
glucosephosphate dehydrogenase deficiencyIkbkg
glycogen storage disease IVRbck1
Graft vs Host DiseaseNod2
GranulomaNod2
Graves OphthalmopathyTnf
Graves' diseaseTnf
Growth DisordersPik3ca
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaPik3ca
Hearing LossTnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SuddenTnf
heart diseaseMapk14
Heat StrokeNfkb1 , Nfkb2 , Rel , Rela , Relb , Tnf
HemimegalencephalyPik3ca
hemochromatosisTnf
hemolytic-uremic syndromeTnf
hepatic encephalopathyTnf
Hepatitis C, ChronicTnfrsf1a
hepatocellular carcinomaAtm , Cyld , Nfkbia , Pik3ca , Tnf
hepatorenal syndromeTnf
hereditary breast ovarian cancer syndromeAtm
hereditary hemorrhagic telangiectasiaTnf
Hereditary Neoplastic SyndromesAtm , Irf1 , Pik3ca , Skp1
Hernias, Diaphragmatic, CongenitalTnf
herpes simplex virus keratitisTnf
herpes zosterTnf
hidradenitis suppurativaTnf
HIV Wasting SyndromeTnf
Hodgkin's lymphomaNfkbia , Rel
human immunodeficiency virus infectious diseaseBirc2 , Lck , Ran , Tnf
Human InfluenzaTnf , Tnfrsf1a
Huntington's diseaseNfkb1
HyperalgesiaTnf , Tnfrsf1a
Hyperbilirubinemia, NeonatalIkbkb
hypercalcemiaTnf
HypercholesterolemiaAtm
hyperhomocysteinemiaTnf
HyperoxaluriaNfkb1
HyperoxiaTnf , Tnfrsf1a
HyperplasiaIkbkb , Pik3ca
hypertensionArrb2 , Ikbkb , Nfkbia , Pik3r1 , Prkca , Rela , Src , Tnf
Hypertrophy, Left VentricularPrkca , Rela
Hypertrophy, Right VentricularPrkca
hypochromic microcytic anemiaTnf
Hypoglossal Nerve InjuriesCsnk2b
hypoglycemiaPik3r1 , Tnf
hypohidrotic ectodermal dysplasiaIkbkg , Traf6
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
HypotensionTnf
HypothermiaTnf
idiopathic pulmonary fibrosisTnf
IgA glomerulonephritisTnf , Tnfrsf1a
Immunodeficiency 12Malt1
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 22Lck
Immunodeficiency 36Pik3r1
Immunodeficiency 37Bcl10
Immunodeficiency 53Relb
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
impotenceTnf
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
infertilityAtm
InflammationChuk , Tnf
inflammatory bowel diseaseIkbkb , Nod2 , Tnf
inflammatory bowel disease 1Nod2
Insulin ResistanceAtm , Ikbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
intermediate uveitisTnf
interstitial cystitisTnf
Intervertebral Disc DisplacementTnf
intestinal diseaseNod2
Intestinal NeoplasmsPrkca
intracranial aneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
iron deficiency anemiaTnf
irritable bowel syndromeIkbkg
ischemiaPrkca , Tnfrsf1a
Kawasaki diseaseTnf
KeloidRan
keratoconjunctivitis siccaTnf
Keratoconus 1Skp1
kidney diseaseRelb , Tnf , Tnfrsf1a
Kidney Reperfusion InjuryAtm , Ikbkb , Src , Tnf , Tnfrsf1a
labyrinthitisTnf
large cell carcinomaPrkca
Laryngeal NeoplasmsNod2
learning disabilityIkbkg
Legionnaires' diseaseNod2 , Tnfrsf1a
leiomyomaCsnk2b
leishmaniasisTnf
leprosyNod2 , Tnf
leukemiaAtm , Birc2
Leukemia, Prolymphocytic, T-CellAtm
listeriosisCyld , Tnf
liver cancerPik3ca
liver diseaseNfkb1 , Tnf
liver neoplasmMapk14 , Tnf
Liver Neoplasms, ExperimentalArrb2 , Tnf
Liver Reperfusion InjuryIkbkg , Tnf , Tnfrsf1a
localized sclerodermaTnf
long QT syndromeSyk
low tension glaucomaTnf
lung adenocarcinomaPik3ca , Pik3r1
lung cancerIrf1 , Pik3ca
lung diseaseIrf1 , Tnf
Lung InjuryNfkbia , Tnf , Tnfrsf1a
Lung NeoplasmsIkbkg , Irf1 , Mapk14 , Nod2 , Pik3ca , Tnf
Lung Reperfusion InjuryTnf
lung small cell carcinomaPik3ca
lung squamous cell carcinomaPik3ca
lupus nephritisTnf , Tnfrsf1a
Lyme diseaseNod2
Lymphatic MetastasisPik3ca , Rela
lymphomaAtm , Malt1 , Rela
lymphopeniaTnf
Macular Dystrophy, Concentric AnnularNod2
malariaTnf
Male Germ Cell TumorBcl10
male infertilityCsnk2a2
malignant gliomaPik3ca , Tnf
malignant mesotheliomaBcl10
MALT lymphomaBcl10
Mammary Neoplasms, AnimalPik3r1 , Ran , Rel , Relb
Mammary Neoplasms, ExperimentalCsnk2a1 , Pik3r1 , Ran , Rela , Relb , Tnf
Manganese PoisoningTnf
mantle cell lymphomaAtm
marginal zone B-cell lymphomaBcl10
mastoiditisRela
medulloblastomaPik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
melanomaAtm , Nfkb1 , Nfkbia , Nfkbie , Pik3ca , Pik3r1 , Syk , Tnf
Melanoma, ExperimentalIkbkb
Memory DisordersRel
Meningeal TuberculosisTnf
meningococcal meningitisNod2
MesotheliomaBcl10 , Syk
Metabolic SyndromeAtm , Tnf , Tnfrsf1a
MetaplasiaNod2
methylmalonic aciduria and homocystinuria type cblCNod2
mevalonic aciduriaTnf
middle cerebral artery infarctionIkbkb , Nfkbia , Nod2 , Tnf
migraineTab2 , Tnf
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
migraine without auraTnf
mitochondrial myopathyTnf
mixed connective tissue diseaseTnf
Mouth NeoplasmsPik3ca
mucocutaneous leishmaniasisTnf
Multiple AbnormalitiesAtm , Chuk
Multiple Hamartoma SyndromePik3ca
multiple myelomaNfkbia , Pik3ca , Tnf
Multiple Organ FailureTnf
multiple sclerosisTnf , Tnfrsf1a
Muscle WeaknessTnfrsf1a
muscular atrophyChuk , Ikbkb , Relb , Tnf
muscular dystrophyTnf
Mycobacterium avium complex diseaseTnf
Mycoplasma pneumoniae pneumoniaTnf
myelodysplastic syndromeTnf
myocardial infarctionAtm , Csnk2a1 , Csnk2b , Nfkbia , Tnf , Tnfrsf1a
Myocardial IschemiaIrf1 , Mapk14 , Nfkbia , Tnf
Myocardial Reperfusion InjuryArrb2 , Mapk14 , Nfkbia , Rela , Tnf
myocardial stunningTnf
myocarditisTnf
myositisTnf
Nasal PolypsTnf , Tnfrsf1a
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaPik3ca
NauseaTnf
NecrosisTnf
Nematode InfectionsPik3r1 , Tnfrsf1a
Neoplasm InvasivenessRela , Src , Tnf
Neoplasm MetastasisChuk , Nfkb1 , Nfkbia , Pik3ca , Src , Tnf
nephrogenic diabetes insipidusPrkca
nephronophthisis-like nephropathy 1Rbx1
Nerve DegenerationTnf
nervous system diseaseTnf
NeuralgiaTnf
neuroblastomaPik3ca
Neurogenic InflammationTnf , Tnfrsf1a
Neuropathy, PainfulTnf
neutropeniaTnf
non-Hodgkin lymphomaBcl10 , Malt1 , Pik3ca
non-small cell lung carcinomaCyld , Irf1 , Pik3ca , Rela , Tnf , Tnfrsf1a
nonalcoholic fatty liver diseaseIkbkg , Tnf
Nonspherocytic Hemolytic Anemia, due to G6PD DeficiencyIkbkg
obesityIkbkb , Pik3r1 , Rela , Tnf , Tnfrsf1a
obstructive sleep apneaRela , Tnf , Tnfrsf1a
Oculomotor Apraxia, Cogan TypeAtm
OKUR-CHUNG NEURODEVELOPMENTAL SYNDROMECsnk2a1
open-angle glaucomaTnf
Optic Nerve InjuriesTnfrsf1a
oral submucous fibrosisTnf
osteoarthritisRan
OsteolysisTnf
osteoporosisAtm , Mapk14
Osteoporosis, PostmenopausalTnf
otitis mediaRela , Tnf
Otitis Media with EffusionTnf
ovarian cancerPik3ca
ovarian cystNfkb1
Ovarian NeoplasmsNod2 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyCsnk2a1 , Csnk2a2 , Csnk2b , Tnf
PainTnf , Tnfrsf1a
pancreatic adenocarcinomaPik3ca
pancreatic cancerAtm , Nfkbia , Rela , Tnf
pancreatitisIkbkb , Nod2
Pancreatitis, Acute NecrotizingNfkbia , Rela
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Tnf
paracoccidioidomycosisTnf
Parkinson's diseaseAtm , Tnf
Parkinsonian DisordersNfkb2 , Rela , Src , Tnf
Pediatric Crohn's DiseaseTnf
penile neoplasmPik3ca
peptic esophagitisTnf
perinatal necrotizing enterocolitisIkbkg , Nod2 , Tnf
periodontitisTnf
Peripheral Nerve InjuriesTnf
peripheral T-cell lymphomaAtm
peritonitisTnf
periventricular leukomalaciaTnf
PFAPA SyndromeNod2
Picornaviridae InfectionsTnf
Pituitary NeoplasmsPrkca
placenta diseaseTnf
plasmacytomaPik3ca , Tnf
Plasmodium falciparum malariaTnf
Pleural EffusionTnf
pleurisyTnf
Pneumococcal MeningitisNod2 , Rela , Tnf
Pneumococcal PneumoniaTnf
pneumoniaIkbkb , Tnf , Tnfrsf1a
Pneumonia, StaphylococcalNod2
polycystic ovary syndromeTab1
POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCYRbck1
PolymyositisTnf , Tnfrsf1a
PolyuriaPrkca
portal hypertensionArrb2 , Pik3r1
pre-eclampsiaTnf
pre-malignant neoplasmAtm , Nfkbia
precursor lymphoblastic lymphoma/leukemiaBcl10
precursor T-lymphoblastic lymphoma/leukemiaBcl10
prediabetes syndromeRelb
Pregnancy Complications, CardiovascularTnf
Premature BirthTnf
Prenatal Exposure Delayed EffectsAtm
primary biliary cirrhosisMap3k14 , Nfkb1 , Tnfrsf1a
primary open angle glaucomaTnf
prostate adenocarcinomaChuk , Ikbkb , Nfkbia , Pik3ca , Rela , Xpo1
prostate cancerChuk , Ikbkb , Nfkb1 , Nfkbia , Pik3ca , Pik3r1
prostate carcinoma in situAtm , Rela
prostatic hypertrophyRela
Prostatic NeoplasmsAtm , Chuk , Map3k7 , Pik3ca , Pik3r1 , Prkca , Rela , Rnf31 , Src , Tnf , Xpo1
Pseudomonas InfectionsTnf , Tnfrsf1a
psoriasisIkbkb , Nfkbia , Rel , Tnf , Tnfrsf1a
psoriatic arthritisNod2 , Tnf
PTEN hamartoma tumor syndromePik3ca
pulmonary edemaTnf
pulmonary emphysemaNfkbia , Tnf
pulmonary fibrosisTnf
pulmonary hypertensionRela , Tnf
pulmonary sarcoidosisTnf
pulmonary tuberculosisIrf1 , Nod2 , Tnf
Radiation Injuries, ExperimentalTnf
Radiation PneumonitisTnf , Tnfrsf1a
radiculopathyTnf
rectal neoplasmPik3ca
relapsing polychondritisTnf
relapsing-remitting multiple sclerosisNod2
renal carcinomaPik3ca
renal cell carcinomaAtm , Birc2 , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
renal fibrosisArrb2 , Tnfrsf1a
renal hypertensionTnf
renovascular hypertensionRela
Reperfusion InjuryIrf1 , Nod2 , Pik3r1 , Prkca , Rela , Src , Tnf , Tnfrsf1a
respiratory allergyTnf
respiratory syncytial virus infectious diseaseIrf1 , Tnf
respiratory system diseaseTnf
Respiratory Tract InfectionsIrf1 , Tnf
restrictive cardiomyopathyMapk14
Retina Reperfusion InjuryTnf
retinal artery occlusionTnf
retinal detachmentTnf , Tnfrsf1a
retinal diseaseTnf
rheumatoid arthritisNfkbie , Rel , Tnf , Tnfrsf1a , Traf6
rhinitisNod2 , Tnf
RhinosinusitisTnf
sarcomaPik3ca , Tnf
SarcopeniaNfkbia
schizophreniaTnf , Xpo1
sciatic neuropathyNfkbia , Ran , Tnf , Tnfrsf1a
scleritisTnf
Seasonal Allergic RhinitisNod2
seborrheic keratosisPik3ca
Seizures, FebrileTnfrsf1a
sensorineural hearing lossTnf
SepsisNod2 , Rela , Tnf
septic arthritisTnf
Septic PeritonitisPik3r1
Sezary's diseaseBcl10
ShockTnf
Shock, HemorrhagicRela , Tnf
SHORT SyndromePik3r1
sickle cell anemiaTnf
silicosisTnf , Tnfrsf1a
Sjogren's syndromeMap3k14 , Nfkbia , Tnf
Skin AbnormalitiesChuk
skin cancerChuk
skin diseaseTnf
Skin NeoplasmsCsnk2a1 , Csnk2a2 , Csnk2b , Cyld , Rela
small cell carcinomaTnf
Smith-Magenis syndromeMap3k14 , Prkca
Soft Tissue NeoplasmsTnf
Spinal Cord CompressionTnf , Tnfrsf1a
Spinal Cord InjuriesAtm , Irf1 , Nfkbia , Rela , Tnf , Tnfrsf1a
SplenomegalyNod2
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaAtm , Csnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Tnfrsf1a
status epilepticusAtm , Rela , Src , Tnf
Stevens-Johnson syndromeCul1 , Rbx1 , Tnf
stomach cancerIrf1 , Pik3ca
Stomach NeoplasmsAtm , Birc2 , Irf1 , Nod2 , Pik3ca , Tnf
StrokeIrf1 , Pik3ca , Src , Tnf
Subarachnoid HemorrhageTnf
Systemic CandidiasisTnf
systemic lupus erythematosusNod2 , Tnf , Tnfrsf1a
TachycardiaTnf
Temporomandibular Joint DisordersTnf
Testicular Germ Cell TumorBcl10
thalassemiaTnf
thrombocytopeniaTnf
THROMBOCYTOPENIA 6Src
thrombosisTnf
thymomaCyld
Thyroid NeoplasmsPik3ca , Tnf
Tongue NeoplasmsTnf
toxic shock syndromeTnf
Toxoplasmosis, OcularNod2
trachomaTnf
transient cerebral ischemiaIkbkb , Nfkb1 , Nod2 , Tnf , Tnfrsf1a
transitional cell carcinomaPik3ca , Rel , Relb , Tnf
Transplant RejectionArrb2 , Ikbkb , Nfkbia , Relb , Tnf
trichinosisTnf
Trichoepithelioma, Multiple Familial, 2Cyld
trigeminal neuralgiaTnf
tuberculosisTnf
Tumor Predisposition SyndromeAtm
type 1 diabetes mellitusRan , Tnf
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusArrb2 , Ikbkb , Nfkb1 , Pik3r1 , Rela , Src , Tnf , Tnfrsf1a
ulcerative colitisNod2 , Rela , Ripk2 , Tnf
ureteral obstructionIrf1 , Relb , Tnf , Tnfrsf1a
urinary bladder cancerAtm , Prkca , Rela , Src , Tnf
urticariaTnf
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsBirc2 , Cyld , Pik3ca , Rela , Tnf
Uterine NeoplasmsPik3ca , Pik3r1 , Xpo1
uveitisNod2 , Rela , Tnf , Tnfrsf1a
vascular diseaseTnf
Vascular MalformationsPik3ca
Vascular System InjuriesTnf
Venous ThromboembolismTnf
Ventilator-Induced Lung InjuryNfkbia
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftAtm
Viral BronchiolitisTnf
viral pneumoniaTnf
visceral leishmaniasisTnf
visual epilepsyPik3ca , Tnf , Tnfrsf1a
vitiligoPik3r1 , Tnf
Vogt-Koyanagi-Harada diseaseTnf
Vulvar VestibulitisTnf
Weight GainPik3ca , Tnf
Weill-Marchesani syndromeTnf
Williams-Beuren syndromeSrc
Wilson diseaseTnf
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesTnf
Wounds, PenetratingTnf
X-linked adrenal hypoplasia congenitaTab3
Pathway Annotations Associated with Genes in the nuclear factor kappa B signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Nfkb1 , Nfkb2 , Nfkbia , Pik3ca
aldosterone signaling pathwayPik3ca , Pik3r1 , Prkca
allograft rejection pathwayTnf
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered Reelin signaling pathwaySrc
altered ubiquitin/proteasome degradation pathwayUbe2d3
Alzheimer's disease pathwayTnf , Tnfrsf1a , Ube2d3
amyotrophic lateral sclerosis pathwayMapk14 , Tnf , Tnfrsf1a
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAtm , Birc2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
asthma pathwayTnf
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm
B cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Malt1 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Syk
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2
calcium/calcium-mediated signaling pathwayPrkca
cell cycle pathway, mitoticAtm , Cul1 , Rbx1 , Skp1
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a
Chagas disease pathwayChuk , Ikbkb , Ikbkg , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
chemokine mediated signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayPik3ca , Pik3r1
corticotropin-releasing hormone signaling pathwayArrb2
CRM1 export pathwayRan , Xpo1
cytokine mediated signaling pathwayTnf , Tnfrsf1a
dilated cardiomyopathy pathwayTnf
dopamine signaling pathwaySrc
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayArrb2 , Lck , Mapk14 , Prkca , Src , Syk
endocytosis pathwayArrb2 , Src , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayCul1 , Rbx1 , Skp1 , Ube2d3
endothelin signaling pathwayMapk14 , Prkca , Src
Entamoebiasis pathwayNfkb1 , Pik3ca , Pik3r1 , Prkca , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisLck , Map3k7 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayPik3ca , Pik3r1 , Prkca , Src
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayMapk14 , Nfkb1 , Pik3r1
estrogen signaling pathwaySrc
FasL mediated signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Mapk14 , Pik3ca , Pik3r1 , Src , Syk
Fc epsilon receptor mediated signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Syk , Tnf
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1 , Prkca , Syk
fibroblast growth factor signaling pathwayPik3ca , Pik3r1 , Src
glioma pathwayPik3ca , Pik3r1 , Prkca
glutamate signaling pathwayPrkca
glypican signaling pathwayLck , Src
gonadotropin-releasing hormone signaling pathwayMapk14 , Prkca , Src
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1 , Syk
Hedgehog signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
hepatitis C pathwayChuk , Ikbkb , Ikbkg , Irf1 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
homologous recombination pathway of double-strand break repairAtm
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRbx1
influenza A pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Prkca , Rela , Tnf , Tnfrsf1a , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca
insulin-like growth factor signaling pathwayPik3ca , Pik3r1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
interleukin-12 signaling pathwayLck , Mapk14 , Nfkb1 , Nfkb2 , Rela , Relb , Ripk2
interleukin-2 signaling pathwayLck , Mapk14 , Pik3ca , Pik3r1 , Syk
interleukin-23 signaling pathwayNfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayMapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayIrf1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmaniasis pathwayMap3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
long term depressionPrkca
long term potentiationPrkca
malaria pathwayTnf
measles pathwayChuk , Csnk2a1 , Csnk2a2 , Csnk2b , Map3k7 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
microRNA pathwayRan
mitochondrial autophagy pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Src
mitogen activated protein kinase signaling pathwayArrb2 , Chuk , Ikbkb , Ikbkg , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Prkca , Rela , Tnf , Tnfrsf1a , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1 , Prkca , Sspo
N-cadherin signaling pathwayPik3ca , Pik3r1
neddylation pathwayCul1 , Rbx1
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayIkbkb , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Ripk2 , Traf6
NOD-like receptor signaling pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nod2 , Rela , Ripk2 , Tnf , Traf6
non-small cell lung carcinoma pathwayPik3ca , Pik3r1 , Prkca
Notch signaling pathwayCul1 , Skp1 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Atm , Bcl10 , Bcl3 , Birc2 , Btrc , Chuk , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Cyld , Erc1 , Ikbkb , Ikbkg , Irf1 , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkb2 , Nfkbia , Nfkbib , Nfkbie , Nod2 , Pik3ca , Pik3r1 , Prkca , Ran , Rbck1 , Rbx1 , Rel , Rela , Relb , Ripk2 , Rnf31 , Sharpin , Skp1 , Src , Sspo , Syk , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a , Traf6 , Ube2d3 , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nucleotide excision repair pathwayRbx1
p38 MAPK signaling pathwayAtm , Irf1 , Map3k7 , Mapk14 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAtm , Mapk14
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayLck , Pik3ca , Pik3r1 , Src , Syk
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1 , Prkca
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1 , Src
phosphoinositide metabolic pathwayPik3ca , Pik3r1
platelet-derived growth factor signaling pathwayCsnk2a1 , Lck , Pik3ca , Pik3r1 , Prkca , Src
primary immunodeficiency pathwayIkbkg , Lck
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Rbx1
protein kinase C (PKC) signaling pathwayLck , Prkca
Reelin signaling pathwayPik3ca , Pik3r1 , Src
renal cell carcinoma pathwayPik3ca , Pik3r1 , Rbx1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Rela , Tnf , Traf6
rheumatoid arthritis pathwayTnf
ribosome biogenesis pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Ran , Xpo1
RNA transport pathwayRan , Xpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
sleeping sickness pathwayPrkca , Tnf
small cell lung carcinoma pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Traf6
somatostatin signaling pathwaySrc
sphingosine 1-phosphate signaling pathwayMapk14 , Src
syndecan signaling pathwayPrkca , Src
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayBcl10 , Chuk , Ikbkb , Ikbkg , Lck , Malt1 , Map3k14 , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Nfkbie , Pik3ca , Pik3r1 , Rela , Tnf
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
toxoplasmosis pathwayBirc2 , Chuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Nfkbib , Pik3ca , Pik3r1 , Rela , Tnf , Tnfrsf1a , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayCul1 , Rbx1 , Skp1 , Tnf
tuberculosis pathwayBcl10 , Malt1 , Mapk14 , Nfkb1 , Nod2 , Rela , Ripk2 , Src , Syk , Tnf , Tnfrsf1a , Traf6
tumor necrosis factor mediated signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
type II interferon signaling pathwayIrf1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayBirc2 , Btrc , Cul1 , Rbx1 , Skp1 , Src , Traf6 , Ube2d3
vascular endothelial growth factor signaling pathwayMapk14 , Pik3ca , Pik3r1 , Prkca , Src
visual phototransduction pathwayArrb2
Wnt signaling pathwayBtrc , Csnk2a1 , Csnk2a2 , Csnk2b , Cul1 , Map3k7 , Prkca , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc
Wnt signaling, non-canonical pathwayArrb2 , Map3k7 , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the nuclear factor kappa B signaling pathway

References Associated with the nuclear factor kappa B signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: