RENIN-ANGIOTENSIN CASCADE PATHWAY (PW:0000492)

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Description

Renin-angiotensin system (RAS) signaling pathway is well known for its cardiovascular roles primarily via the circulating or 'classical' route and also, has become recognized as a complex system with pleiotropic effects that engages both the circulating and the local or 'tissue' routes. Originally viewed as solely endocrine, the system is now regarded as an endocrine, paracrine and autocrine one producing an array of diverse and many times opposing actions. Underlying the system's ability of pro

Pathway Diagram:

Ariadne Genomics Inc. Ren Agtr2 Agtr1a Agtr1b Mas1 Lnpep angiotensin III signaling via AT2 receptor angiotensin III signaling pathway angiotensin (1-7) signaling pathway angiotensin IV signaling pathway angiotensin II signaling pathway angiotensin II signaling via AT2 receptor angiotensin II signaling via AT1 receptor Enpep Anpep Mme Ace2 Ace renin receptor mediated intracellular signaling angiotensin IV signaling pathway ---> cognition AgtIII ---- Agtr1a Renbp ---| Ren Renbp Agt ---> AgtI AgtIII ---- Agtr2 cognition AgtII ---- Agtr1b AgtIV ---- Lnpep AgtII ---- Agtr2 AgtI ---> AgtII Igf2r ---- Ren angiotensin III signaling via AT1 receptor ---> cell proliferation vasodilation AgtII ---- Agtr1a angiotensin III signaling via AT2 receptor ---> vasodilation angiotensin II signaling via AT2 receptor ---> vasodilation Atp6ap2 ---- Ren Cma1 Atp6ap2 ---> renin receptor mediated intracellular signaling Igf2r cell proliferation vasoconstriction angiotensin II signaling via AT1 receptor ---> cell proliferation Igf2r ---> complex internalization complex internalization AgtII ---> AgtIII Agt AgtI ---> Agt(1-7) AgtIII ---> AgtIV AgtII ---> Agt(1-7) AgtIII ---- Agtr1b AgtI Agt(1-7) AgtIII AgtIV AgtII Ren ---- Renbp Ren ---> renin receptor mediated intracellular signaling angiotensin III signaling via AT1 receptor angiotensin III signaling via AT1 receptor ---> vasoconstriction angiotensin II signaling via AT1 receptor ---> vasoconstriction angiotensin (1-7) signaling pathway ---> vasodilation Atp6ap2 Agt(1-7) ---- Mas1
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Genes in Pathway:

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renin-angiotensin cascade pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
RGD:6907045
RGD:1581953
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:1581742
RGD:6907045
RGD:1581931
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581651
RGD:6907045
RGD:1582105
RGD:1581742
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581847
RGD:6907045
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581847
RGD:6907045
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581855
RGD:6907045
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
RGD:6907045
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:5132617
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581742
RGD:6907045
G Cpa3 carboxypeptidase A3 JBrowse link 2 105,016,798 105,047,989 RGD:6907045
G Ctsa cathepsin A JBrowse link 3 161,298,750 161,304,627 RGD:6907045
G Ctsg cathepsin G JBrowse link 15 35,107,333 35,113,678 RGD:6907045
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
RGD:6907045
RGD:1581742
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:1581738
RGD:1581739
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581849
RGD:6907045
RGD:1582105
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581849
RGD:6907045
RGD:1581931
G Mcpt8l2 mast cell protease 8-like 2 JBrowse link 15 34,622,126 34,625,079 RGD:6907045
G Mcpt8l3 mast cell protease 8-like 3 JBrowse link 15 34,667,266 34,670,303 RGD:6907045
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:6907045
RGD:1581953
RGD:1581931
G Nln neurolysin JBrowse link 2 34,086,970 34,185,835 RGD:6907045
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:1581651
RGD:6907045
RGD:1581742
RGD:1581739
RGD:1581738
G Renbp renin binding protein JBrowse link X 156,854,490 156,863,548 RGD:5132613
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
G Thop1 thimet oligopeptidase 1 JBrowse link 7 11,501,145 11,513,576 RGD:6907045
angiotensin (1-7) signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581953
RGD:1598433
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581938
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:1581938
RGD:1581931
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1581742
RGD:1581931
RGD:1581953
angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:12910844
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:5133683
RGD:2316188
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:7401256
RGD:1582435
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679
angiotensin III signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582124
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582124
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582124
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582124
G Enpep glutamyl aminopeptidase JBrowse link 2 233,667,253 233,743,866 RGD:1581649
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582152
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1582152
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1582152
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582118
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1582118
angiotensin IV signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582105
G Anpep alanyl aminopeptidase, membrane JBrowse link 1 141,561,364 141,604,249 RGD:1581649
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1581864
RGD:1582105
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:1581649
angiotensin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1566511

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgt(1-7)angiotensinogen derived peptide
ProteinAgtIIangiotensinogen derived peptide
ProteinAgtIIIangiotensinogen derived peptide
ProteinAgtIVangiotensinogen derived peptide

Pathway Gene Annotations

Disease Annotations Associated with Genes in the renin-angiotensin cascade pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAce , Ace2 , Agt , Agtr1a
Abortion, SpontaneousAce2 , Agtr1a
acute kidney failureAce
adenocarcinomaAce
adult respiratory distress syndromeAce
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt , Ren
alcoholic cardiomyopathyAce , Agt
alcoholic hepatitisAgt
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a , Ren
allergic hypersensitivity diseaseAce , Agt
allergic rhinitisAce
Alzheimer's diseaseAce , Agt , Agtr1a , Igf2r , Mme
amyotrophic lateral sclerosisIgf2r
AnaphylaxisAgt , Cma1
anemiaAce , Agt , Ren
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
ankylosing spondylitisAce
anti-basement membrane glomerulonephritisAgt , Agtr1a
anuriaAgt
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAce , Agt
Arteriovenous FistulaAce
aspiration pneumoniaAce
asthmaAce , Agtr1a , Agtr2 , Cma1
atherosclerosisAgt
atopic dermatitisCma1
atrial fibrillationAce , Agt , Agtr1a , Ren
autistic disorderAce
autosomal recessive polycystic kidney diseaseAce
AzotemiaRen
Bartter diseaseRen
Behcet's diseaseAce
berylliosisAce
bipolar disorderAce , Agt
BradycardiaAgt
brain ischemiaAce
Breast NeoplasmsAce , Agt , Agtr1a , Igf2r , Lnpep , Mme
bronchiolitis obliteransAce
Cardiac ArrhythmiasAce , Agt , Agtr1a
Cardiac FibrosisAce2
CardiomegalyAce , Agt , Agtr1a , Agtr1b , Cma1 , Ren
cardiomyopathyAgt
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAce , Agt
carotid artery diseaseAce , Agt , Agtr1a
Carotid Artery InjuriesAgtr1a
CatalepsyAgt
cerebral amyloid angiopathyMme
Cerebral HemorrhageAce
cerebral infarctionAce
cerebrovascular diseaseAgt , Agtr1a
Charcot-Marie-Tooth disease axonal type 2TMme
Chemotherapy-Induced Febrile NeutropeniaAce
cholestasisAgt
chronic fatigue syndromeRen
Chronic Intermittent HypoxiaAce , Agt
chronic kidney diseaseAgtr1a , Agtr2
chronic myeloid leukemiaAce , Agt
chronic obstructive pulmonary diseaseAce , Cma1
Cognition DisordersAgt
congenital diaphragmatic herniaAgt , Agtr1a , Agtr1b
congenital heart diseaseCma1
Congenital Hepatic FibrosisAce
congestive heart failureAce , Ace2 , Agt , Agtr1a , Agtr2 , Mas1 , Ren
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAce , Agt , Agtr1a
Coronary DiseaseAce , Ace2 , Agtr1a
coronary restenosisAce
Coronavirus InfectionsAce
CoughAce
Craniofacial AbnormalitiesAtp6ap2
Crohn's diseaseAgt
Cryopyrin-Associated Periodic SyndromesMme
Diabetic CardiomyopathiesAce , Ace2 , Agtr2
Diabetic NephropathiesAce , Ace2 , Agt , Agtr1a , Agtr2 , Lnpep , Ren
diabetic neuropathyMme
diabetic retinopathyAce , Ace2 , Agt , Agtr1a
diffuse sclerodermaAgt
dilated cardiomyopathyAce , Agt , Agtr1a , Agtr2 , Mas1 , Renbp
Dissecting AneurysmAgt
drug allergyAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsRen
Ductal CarcinomaAgtr1a
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsRenbp
end stage renal failureAce , Agt , Agtr2
Endometrial NeoplasmsLnpep
Endometrioid CarcinomasLnpep
endomyocardial fibrosisAce , Ace2 , Agt
EndotoxemiaAce , Agtr2
essential hypertensionAgt , Agtr1a
Experimental ArthritisAce
Experimental Diabetes MellitusAce , Ace2 , Agt , Agtr2 , Cma1 , Igf2r , Mas1 , Ren
Experimental Liver CirrhosisAce2 , Agt , Agtr1a , Enpep , Igf2r , Mas1 , Mme
extrinsic allergic alveolitisAce
Fabry diseaseAce , Agt
Familial Cerebral Cavernous MalformationAce
familial juvenile hyperuricemic nephropathyRen
Familial Juvenile Hyperuricemic Nephropathy 2Ren
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Agtr2 , Ren
FibrosisAgt , Agtr1a , Agtr2 , Atp6ap2 , Ren
focal segmental glomerulosclerosisAgt , Agtr1a , Agtr2
focal segmental glomerulosclerosis 1Ace
Gallbladder NeoplasmsAce
gastric ulcerAgt
Gaucher's diseaseAce
genetic diseaseMme
Genetic Predisposition to DiseaseAce
glaucomaAce2 , Mas1
glomerulonephritisAce , Agt , Agtr2
glomerulosclerosisAce , Agtr1a , Agtr2
glucose intoleranceAgt , Agtr1a
glycogen storage disease VAce
GranulomaCma1
heart diseaseAgt
HemorrhageAgt , Ren
Henoch-Schoenlein purpuraAce , Agt
hepatocellular carcinomaAce , Igf2r
Hereditary Neoplastic SyndromesLnpep
Hernias, Diaphragmatic, CongenitalAce , Agtr2 , Igf2r
Huntington's diseaseAgtr1a
hydronephrosisAgt
Hydrops FetalisCtsa
HyperalgesiaAgt
HyperemiaAgt
hyperinsulinismAgt , Agtr1a
HyperoxiaAce
hypertensionAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1 , Mas1 , Ren , Rnpep
Hypertension, Pregnancy-InducedAce , Ace2 , Agt
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce
hypertrophic cardiomyopathyAce , Agt , Cma1
HypertrophyAgt
Hypertrophy, Left VentricularAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1 , Ren
Hypertrophy, Right VentricularAce
hypoglycemiaAgtr2
hypokalemiaAgt
HypotensionAce , Agt , Ren
Hypoxia-Ischemia, BrainAgtr2
IgA glomerulonephritisAce , Agt , Agtr1a , Agtr2
impotenceAgt
in situ carcinomaAce , Igf2r
Infant, Premature, DiseasesAce
InflammationAgt , Agtr1a , Agtr2
inflammatory bowel diseaseAgt
Insulin ResistanceAce , Agtr2
intellectual disabilityAgtr2
intermediate coronary syndromeAce , Agt , Agtr1a
interstitial lung diseaseCma1
Intestinal Reperfusion InjuryAce , Agt
intracranial aneurysmAce
invasive lobular carcinomaAgtr1a , Agtr2
ischemiaRen
kidney diseaseAce , Agt , Agtr1a , Ren
kidney failureAce , Agt , Mme
Kidney Reperfusion InjuryAce , Ace2
leiomyomaLnpep
leukemiaAce
leukostasisAce
Lewy body dementiaIgf2r
Liddle syndromeRen
Limb IschemiaAgtr1a
liver cancerIgf2r
liver cirrhosisAgt , Ren
Liver Neoplasms, ExperimentalIgf2r
lung diseaseAce , Ace2 , Agtr1a , Igf2r
Lung InjuryMme
Lung NeoplasmsAce , Igf2r
lysosomal storage diseaseCtsa
male infertilityAce
malignant hypertensionAgt , Ren
Mammary Neoplasms, ExperimentalAgt , Agtr1a , Agtr2 , Lnpep , Rnpep
meconium aspiration syndromeAgt , Agtr2
membranous glomerulonephritisMme
Memory DisordersAce , Lnpep
Meningococcal InfectionsAce
Mental Retardation, X-LinkedAgtr2
Mental Retardation, X-Linked 88Agtr2
Metabolic SyndromeAgt , Agtr1a
Microvascular Complications of Diabetes, Susceptibility to, 2Ace
Microvascular Complications of Diabetes, Susceptibility to, 3Ace
Microvascular Complications of Diabetes, Susceptibility to, 4Ace
Microvascular Complications of Diabetes, Susceptibility to, 6Ace
Microvascular Complications of Diabetes, Susceptibility to, 7Ace
middle cerebral artery infarctionAce , Ace2 , Agt
mitral valve prolapseAce , Agt
multiple myelomaAce
multiple sclerosisAgt
myocardial infarctionAce , Ace2 , Agt , Agtr1a , Ren
Myocardial IschemiaAgt
Myocardial Reperfusion InjuryAgt , Agtr1a
myocarditisAce , Cma1
NecrosisAgt
NeointimaAgt
Neoplasm MetastasisAce , Agtr1a , Agtr2
nephritisAce , Agtr1a
nephroblastomaIgf2r
nephrosisAce , Agt , Ren
Nephrosis, Puromycin AminonucleosideAce , Agt , Ren
nephrotic syndromeAce
Neuraminidase Deficiency with Beta-Galactosidase DeficiencyCtsa
non-arteritic anterior ischemic optic neuropathyAce
non-syndromic X-linked intellectual disabilityAgtr2
nonalcoholic fatty liver diseaseAce
obesityAce , Agt , Agtr2 , Ren
obstructive sleep apneaAce
ocular hypotensionAce
osteoporosisAce , Ren
otosclerosisAgt
ovarian cystAgtr2
Ovarian NeoplasmsLnpep
PainAce
pancreatic cancerAce , Agtr2
pancreatic ductal carcinomaAce , Ace2 , Agtr1a
Parkinson's diseaseAce , Agtr1a , Igf2r
Parkinsonism with Spasticity, X-LinkedAtp6ap2
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
Peritoneal FibrosisAce
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
pneumoniaAce , Agt
Polycystic Kidney DiseasesAgt
polycythemiaAce
polyhydramniosLnpep
portal hypertensionRen
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
pre-eclampsiaAce , Agt
pre-malignant neoplasmAce
prediabetes syndromeAgt
Prenatal Exposure Delayed EffectsAgtr1b
primary biliary cirrhosisAce , Ace2 , Agt , Mas1 , Ren
primary hyperaldosteronismAgtr1b
prostate cancerIgf2r
Prostatic NeoplasmsAce , Igf2r , Mme
proteinuriaAce , Agt , Agtr1a , Ren
psoriasisRen
pulmonary edemaAgt
pulmonary fibrosisAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1
pulmonary hypertensionAce , Agt , Agtr1a
pyelonephritisAce
Radiation Injuries, ExperimentalAgtr1a , Agtr2
Radiation NephropathyAce
renal cell carcinomaAgtr1a , Agtr2 , Lnpep
renal fibrosisAce
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a , Ren
renovascular hypertensionAce , Agtr1a , Agtr1b , Agtr2 , Ren
Reoviridae InfectionsIgf2r
Reperfusion InjuryAce , Agt , Agtr2 , Ctsg
respiratory system diseaseAce
Retina Reperfusion InjuryRen
retinal vasculitisAgt
retinopathy of prematurityAgt
sarcoidosisAce , Agtr1a , Cma1
sciatic neuropathyAgt
Seasonal Allergic RhinitisCma1
severe acute respiratory syndromeAce
sick sinus syndromeAgt
skin melanomaAgt
Smith-Magenis syndromeAce
Spinocerebellar Ataxia 43Mme
Spinocerebellar AtaxiasMme
Staphylococcal InfectionsAce
Stomach NeoplasmsAce , Agtr2
StrokeAce , Agt , Agtr2
substance-induced psychosisAce
Sudden DeathAce , Agt
syndromic X-linked intellectual disability Hedera typeAtp6ap2
systemic lupus erythematosusAce , Agtr2
systemic sclerodermaAce , Agt
temporal lobe epilepsyAgt
thrombosisAce2 , Agt , Mas1
transient cerebral ischemiaAgt
type 1 diabetes mellitusAce , Igf2r
type 2 diabetes mellitusAce , Agt , Agtr2 , Igf2r , Lnpep
ureteral obstructionAce , Agt
urinary bladder cancerAnpep
Urogenital AbnormalitiesAgtr2
uveitisAce
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr1a , Agtr2
Venous ThromboembolismAce
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Ace2 , Agtr1a
vesicoureteral refluxAgtr1a , Agtr2
viral pneumoniaAce
visual epilepsyAgt
Water-Electrolyte ImbalanceAgtr1b
Weight GainAce
withdrawal disorderRen
Pathway Annotations Associated with Genes in the renin-angiotensin cascade pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
Alzheimer's disease pathwayMme
amino sugar metabolic pathwayRenbp
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt , Mas1 , Mme
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2 , Enpep
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt , Anpep , Lnpep , Rnpep
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
Chagas disease pathwayAce
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
Entamoebiasis pathwayCtsg , Mcpt8l2 , Mcpt8l3
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
french type sialuria pathwayRenbp
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
glutathione metabolic pathwayAnpep
glutathione synthase deficiency pathwayAnpep
glutathionuria disease pathwayAnpep
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayLnpep
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt , Lnpep
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
nucleotide sugar metabolic pathwayRenbp
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Anpep , Atp6ap2 , Cma1 , Cpa3 , Ctsa , Ctsg , Enpep , Igf2r , Lnpep , Mas1 , Mcpt8l2 , Mcpt8l3 , Mme , Nln , Ren , Renbp , Rnpep , Thop1
sialic acid storage disease pathwayRenbp
sleeping sickness pathwayThop1
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
systemic lupus erythematosus pathwayCtsg , Mcpt8l2 , Mcpt8l3
Tay-Sachs disease pathwayRenbp
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the renin-angiotensin cascade pathway

References Associated with the renin-angiotensin cascade pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: