TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000490)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The superfamily of ligands can be divided into two main groups: the Tgf-b/activin and the bone morphogenetic protein (BMP)/growth and differentiation factor (GDF) - both can be further subdivided. The serine/threonine kinase receptor superfamily is represented by the type I and II receptors that c

Pathway Diagram:

Elsevier Inc. Dcn A2m Tgfbr3 Smad7 Fkbp1a Smad4 Smad3 ---- Zfyve9 Smad2 Smad3 Translocated Smad Zfyve9 Tgfb1 Tgfbr1 Tgfbr2 Smad7 ---| Tgfbr1 Smurf2 Smurf1 Tgf-beta target genes Transcription factors/co-activators Smad2 ---- Smad4 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Tgfbr2 --+> Tgfbr1 Smad7 ---| Tgfbr1 Smad3 ---- Smad4 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfbr1 --+> Smad2 Tgfbr1 --+> Smad3 Tgfb1 ---- Tgfbr1 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgfb1 ---- Tgfbr2 Smad3 ---> Translocated Smad Smad2 ---> Translocated Smad Smad4 ---> Translocated Smad Translocated Smad ---> Tgf-beta target genes Tgf-beta target genes ---> Smad7
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Genes in Pathway:

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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:2298922
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:5143919
RGD:2302137
G Axin1 axin 1 RGD:6484113
G Bambi BMP and activin membrane-bound inhibitor JBrowse link 17 56,905,419 56,909,675 RGD:6484113
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:1625706
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:5143919
RGD:2302137
G Ctgf connective tissue growth factor JBrowse link 1 21,851,657 21,854,773 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Dact2 dishevelled-binding antagonist of beta-catenin 2 JBrowse link 1 56,159,435 56,169,443 RGD:6484113
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6484113
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:2298922
G Dynlrb1 dynein light chain roadblock-type 1 JBrowse link 3 150,761,329 150,782,493 RGD:6484113
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6484113
G Fkbp1a FK506 binding protein 1a JBrowse link 3 147,042,944 147,062,725 RGD:2298922
RGD:6484113
G Foxh1 forkhead box H1 JBrowse link 7 117,730,307 117,733,076 RGD:5143919
RGD:2302137
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:5143919
RGD:2302137
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:5143919
RGD:2302137
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:5143919
RGD:2302137
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6484113
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6484113
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6484113
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6484113
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:6484113
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6484113
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6484113
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:6484113
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:6484113
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rnf111 ring finger protein 111 JBrowse link 8 76,864,343 76,940,235 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
G Runx1 runt-related transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:5143919
RGD:2302137
G Runx2 runt-related transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:5143919
RGD:2302137
G Runx3 runt-related transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:5143919
RGD:2302137
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6484113
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:6484113
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1599906
RGD:6484113
RGD:2302517
RGD:2298922
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1599906
RGD:6484113
RGD:1299323
RGD:1625706
RGD:2298922
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1599906
RGD:6484113
RGD:2298922
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2298922
RGD:6484113
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:2298922
RGD:6484113
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:2298922
RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6484113
G Sptbn1 spectrin, beta, non-erythrocytic 1 JBrowse link 14 114,517,839 114,700,199 RGD:6484113
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2298921
RGD:6484113
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:2298921
RGD:6484113
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:2298922
RGD:6484113
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2298922
RGD:2302517
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2298921
RGD:6484113
RGD:2302517
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:2298922
RGD:6484113
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 5 33,608,489 33,696,487 RGD:6484113
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Zfyve16 zinc finger FYVE-type containing 16 JBrowse link 2 22,060,879 22,105,822 RGD:6484113
G Zfyve9 zinc finger FYVE-type containing 9 JBrowse link 5 128,233,096 128,392,675 RGD:2298922
RGD:6484113
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490966
RGD:5490965

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Pathway Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a , Smad2 , Smad3
acute myeloid leukemia pathwayGrb2 , Pml , Rps6kb1 , Runx1 , Sos1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp2ca
adenosine signaling pathwayCreb1 , Pard6a , Pdpk1
aldosterone signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayAxin1 , Ctnnb1
Alzheimer disease pathwayA2m
amyotrophic lateral sclerosis disease pathwayDaxx
androgen signaling pathwayCrebbp
angiotensin II signaling pathwayPdpk1
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayXiap
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
B cell receptor signaling pathwayGrb2 , Sos1
basal cell carcinoma pathwayAxin1 , Ctnnb1
Bone morphogenetic proteins signaling pathwayBambi , Map3k7 , Ppp1ca , Ppp1r15a , Smad4 , Smad7 , Smurf1 , Smurf2 , Tab1 , Tab2 , Xiap , Zfyve16
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2 , Rhoa
calcium/calcium-mediated signaling pathwayCamk2a
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Ppp2ca
cell cycle pathway, mitoticCrebbp , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Ywhae
ceramide signaling pathwayEif2a , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayArrb2 , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1
chronic myeloid leukemia pathwayGrb2 , Runx1 , Shc1 , Smad3 , Smad4 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
coagulation cascade pathwayA2m
colorectal cancer pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
complement system pathwayA2m
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
dopamine signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCtnnb1 , Rhoa
eicosanoid signaling pathwayArrb2 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayArrb2 , Cav1 , Itch , Nedd4l , Pard6a , Pml , Rhoa , Smad2 , Smad3 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Wwp1 , Zfyve16 , Zfyve9
endometrial cancer pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
endoplasmic reticulum stress - the unfolded protein response pathwayEif2a
Endoplasmic Reticulum-associated degradation pathwayPpp1r15a
endothelin signaling pathwayRhoa
Entamoeba histolyca infection pathwayTgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Map3k7 , Rhoa
epidermal growth factor/neuregulin signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayGrb2 , Shc1 , Sos1
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayGrb2 , Sos1
Fc gamma receptor mediated signaling pathwayRps6kb1
fibroblast growth factor signaling pathwayCamk2a , Grb2 , Pdpk1 , Runx2 , Shc1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1 , Ppp1ca
forkhead class A signaling pathwayCreb1 , Crebbp
glioma pathwayCamk2a , Grb2 , Shc1 , Sos1
glycogen biosynthetic pathwayPpp1ca
glycogen degradation pathwayPpp1ca
glypican signaling pathwaySmad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayCamk2a , Grb2 , Sos1
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Shc1 , Sos1
Hedgehog signaling pathwayArrb2 , Crebbp , Tgfb2
hepatitis C virus infection pathwayGrb2 , Ocln , Ppp2ca , Ppp2cb , Ppp2r2a , Sos1
histamine signaling pathway, immunologicalCreb1 , Ppp1ca
histone modification pathwayCrebbp , Daxx
Huntington disease pathwayCreb1 , Crebbp
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayCreb1 , Crebbp , Smad3 , Smad4
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A virus infection pathwayCrebbp , Pml
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhae
insulin signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
insulin-like growth factor signaling pathwayGrb2 , Pdpk1 , Rps6kb1 , Shc1 , Sos1 , Ywhae
interleukin-1 signaling pathwayMap3k7 , Tab1 , Tab2
interleukin-2 signaling pathwayGrb2 , Rhoa , Shc1 , Sos1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Shc1
interleukin-4 signaling pathwayGrb2 , Rps6kb1 , Shc1
interleukin-5 signaling pathwayGrb2
interleukin-6 signaling pathwayA2m , Foxo1 , Grb2 , Sos1
intrinsic apoptotic pathwayXiap
Jak-Stat signaling pathwayCrebbp , Grb2 , Sos1
kallikrein-kinin cascade pathwayA2m
kinin signaling pathwayArrb2
Leishmania infection pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionPpp2ca , Ppp2cb
long term potentiationCamk2a , Crebbp , Ppp1ca
luteinizing hormone signaling pathwayCreb1 , Ppp1ca
measles infection pathwayMap3k7
mitochondria transport pathwayDynlrb1
mitogen activated protein kinase signaling pathwayArrb2 , Daxx , Grb2 , Map3k7 , Shc1 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r2a
mTOR signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
Mycobacterium tuberculosis infection pathwayCamk2a , Creb1 , Crebbp , Rhoa , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Rhoa
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayCamk2a , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1 , Ywhae
NOD-like receptor signaling pathwayMap3k7 , Xiap
non-small cell lung cancer pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
Notch signaling pathwayCrebbp , Itch
nuclear factor kappa B signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p38 MAPK signaling pathwayMap3k7 , Tab1 , Tab2
p53 signaling pathwayCrebbp , Daxx , Ppp2ca
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Pdpk1 , Rhoa
phosphatidylinositol 3-kinase-Akt signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
Plasmodium infection pathwayTgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayCav1 , Grb2 , Ppp2ca , Rhoa , Shc1 , Sos1 , Ywhae
prostate cancer pathwayCreb1 , Crebbp , Ctnnb1 , Foxo1 , Grb2 , Pdpk1 , Sos1
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1
Ras family mediated signaling pathwaySos1
renal cell cancer pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k7
reverse cholesterol transport pathwayCav1
rheumatoid arthritis disease pathwayTgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayRhoa
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayStrap
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1 , Ppp1ca
small cell lung cancer pathwayXiap
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa , Tgfb1
T cell receptor signaling pathwayGrb2 , Map3k7 , Rhoa , Sos1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayShc1
thyroid cancer pathwayCtnnb1
Toll-like receptor signaling pathwayMap3k7 , Tab1 , Tab2
Toxoplasma gondii infection pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3 , Xiap
transforming growth factor-beta Smad dependent signaling pathwayA2m , Arrb2 , Atf3 , Axin1 , Bambi , Camk2a , Cav1 , Creb1 , Crebbp , Ctgf , Ctnnb1 , Dact2 , Daxx , Dcn , Dynlrb1 , Eif2a , Fkbp1a , Foxh1 , Foxo1 , Foxo3 , Foxo4 , Grb2 , Itch , Map3k7 , Nedd4l , Ocln , Pard6a , Pdpk1 , Pml , Ppp1ca , Ppp1r15a , Ppp2ca , Ppp2cb , Ppp2r2a , Rhoa , Rnf111 , Rps6kb1 , Runx1 , Runx2 , Runx3 , Shc1 , Skil , Smad2 , Smad3 , Smad4 , Smad7 , Smurf1 , Smurf2 , Sos1 , Sptbn1 , Strap , Tab1 , Tab2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tgfbr3 , Wwp1 , Xiap , Ywhae , Zfyve16 , Zfyve9
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Dcn , Ppp2ca , Ppp2cb , Rhoa , Rps6kb1 , Smad2 , Smad3 , Smad4 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16 , Zfyve9
Trypanosoma cruzi infection pathwayPpp2ca , Ppp2cb , Ppp2r2a , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tumor necrosis factor mediated signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
type II interferon signaling pathwayCamk2a , Crebbp , Smad7
ubiquitin/proteasome degradation pathwayItch , Nedd4l , Pml , Smurf2 , Wwp1 , Xiap
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1 , Grb2 , Pdpk1 , Rhoa
vasopressin signaling pathway via receptor type 2Creb1
visual phototransduction pathwayArrb2
Wnt signaling pathwayAxin1 , Camk2a , Crebbp , Ctnnb1 , Map3k7 , Ppp2ca , Ppp2cb , Rhoa , Smad2 , Smad3 , Smad4
Wnt signaling, canonical pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
Wnt signaling, non-canonical pathwayArrb2 , Camk2a , Map3k7 , Rhoa , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRhoa
Phenotype Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
cardiac hypertrophyA2m , Crebbp
liver fibrosisSmad3

References Associated with the transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: