TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000490)

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Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The superfamily of ligands can be divided into two main groups: the Tgf-b/activin and the bone morphogenetic protein (BMP)/growth and differentiation factor (GDF) - both can be further subdivided. The serine/threonine kinase receptor superfamily is represented by the type I and II receptors that c

Pathway Diagram:

Elsevier Inc. Dcn A2m Tgfbr3 Smad7 Fkbp1a Smad4 Smad3 ---- Zfyve9 Smad2 Smad3 Translocated Smad Zfyve9 Tgfb1 Tgfbr1 Tgfbr2 Smad7 ---| Tgfbr1 Smurf2 Smurf1 Tgf-beta target genes Transcription factors/co-activators Smad2 ---- Smad4 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Tgfbr2 --+> Tgfbr1 Smad7 ---| Tgfbr1 Smad3 ---- Smad4 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfbr1 --+> Smad2 Tgfbr1 --+> Smad3 Tgfb1 ---- Tgfbr1 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgfb1 ---- Tgfbr2 Smad3 ---> Translocated Smad Smad2 ---> Translocated Smad Smad4 ---> Translocated Smad Translocated Smad ---> Tgf-beta target genes Tgf-beta target genes ---> Smad7
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Genes in Pathway:

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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:2298922
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:5143919
RGD:2302137
G Axin1 axin 1 RGD:6484113
G Bambi BMP and activin membrane-bound inhibitor JBrowse link 17 56,905,419 56,909,675 RGD:6484113
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:1625706
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:5143919
RGD:2302137
G Ctgf connective tissue growth factor JBrowse link 1 21,851,657 21,854,773 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Dact2 dishevelled-binding antagonist of beta-catenin 2 JBrowse link 1 56,159,435 56,169,443 RGD:6484113
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6484113
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:2298922
G Dynlrb1 dynein light chain roadblock-type 1 JBrowse link 3 150,761,329 150,782,493 RGD:6484113
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6484113
G Fkbp1a FK506 binding protein 1a JBrowse link 3 147,042,944 147,062,725 RGD:2298922
RGD:6484113
G Foxh1 forkhead box H1 JBrowse link 7 117,730,307 117,733,076 RGD:5143919
RGD:2302137
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:5143919
RGD:2302137
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:5143919
RGD:2302137
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:5143919
RGD:2302137
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6484113
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6484113
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6484113
G Pard6a par-6 family cell polarity regulator alpha JBrowse link 19 37,668,133 37,670,450 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:6484113
G Ppp1ca protein phosphatase 1 catalytic subunit alpha JBrowse link 1 219,439,953 219,443,570 RGD:6484113
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6484113
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6484113
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:6484113
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:6484113
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rnf111 ring finger protein 111 JBrowse link 8 76,864,343 76,940,235 RGD:6484113
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6484113
G Runx1 runt-related transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:5143919
RGD:2302137
G Runx2 runt-related transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:5143919
RGD:2302137
G Runx3 runt-related transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:5143919
RGD:2302137
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6484113
G Skil SKI-like proto-oncogene JBrowse link 2 115,862,932 115,891,304 RGD:6484113
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1599906
RGD:6484113
RGD:2302517
RGD:2298922
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1599906
RGD:6484113
RGD:1299323
RGD:1625706
RGD:2298922
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1599906
RGD:6484113
RGD:2298922
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2298922
RGD:6484113
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:2298922
RGD:6484113
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:2298922
RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6484113
G Sptbn1 spectrin, beta, non-erythrocytic 1 JBrowse link 14 114,517,839 114,700,199 RGD:6484113
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2298921
RGD:6484113
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:2298921
RGD:6484113
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:2298922
RGD:6484113
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2298922
RGD:2302517
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2298921
RGD:6484113
RGD:2302517
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:2298922
RGD:6484113
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 5 33,608,489 33,696,487 RGD:6484113
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Zfyve16 zinc finger FYVE-type containing 16 JBrowse link 2 22,060,879 22,105,822 RGD:6484113
G Zfyve9 zinc finger FYVE-type containing 9 JBrowse link 5 128,233,096 128,392,675 RGD:2298922
RGD:6484113
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:2306282
RGD:2308865
RGD:5490966
RGD:5490965

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouptranscription factors/co-activatorstranscription factors/co-activators associated with Smad2/3-4
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCav1
Aberrant Crypt FociCtnnb1 , Tgfb2
Abnormalities, Drug-InducedRhoa
Abortion, SpontaneousTgfb1 , Tgfbr1
acoustic neuromaCav1
Acro-OsteolysisSmad4
Acromicric DysplasiaSmad2 , Tgfb1
actinic keratosisTgfb1
acute kidney failureA2m , Ocln , Tgfb1
Acute Lung InjuryCav1 , Tgfb1
acute myeloid leukemiaCrebbp , Foxo1 , Runx1 , Runx3
acute promyelocytic leukemiaPml
adenocarcinomaCtgf , Ctnnb1 , Runx3 , Strap , Tgfb1
adenoid cystic carcinomaCrebbp , Foxo3
adenomaCtnnb1
adrenal carcinomaCtnnb1
Adrenal Gland NeoplasmsCtnnb1
adrenocortical carcinomaCtnnb1 , Daxx
agnathia-otocephaly complexFoxh1
alcohol-induced mental disorderFoxo4
alcoholic liver cirrhosisSmad3 , Tgfb1
Alcoholic Liver DiseasesCav1
allergic conjunctivitisTgfb1
allergic hypersensitivity diseaseTgfb1
Alpha-2-Macroglobulin DeficiencyA2m
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseA2m , Camk2a , Cav1 , Crebbp , Ctnnb1 , Foxo3 , Runx1 , Shc1
Amaurosis FugaxPpp1r15a
amphetamine abuseArrb2
amyotrophic lateral sclerosisPpp1r15a , Runx1
amyotrophic lateral sclerosis type 1Crebbp , Shc1 , Xiap
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
angiosarcomaCtnnb1
Animal Disease ModelsRhoa
ankylosing spondylitisRunx3
aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
aortic diseaseSmad4
aortic valve insufficiencyCtgf , Tgfb1 , Tgfb2
aplastic anemiaTgfb1
arrhythmogenic right ventricular cardiomyopathyTgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arsenic PoisoningSkil
ARTERIAL DISSECTIONSmad3
arteriosclerosisTgfb1 , Tgfbr2
Arteriovenous FistulaArrb2
arteriovenous malformations of the brainZfyve16
asthmaDcn , Ppp2ca , Rhoa , Runx1 , Runx3 , Tgfb1
Asthma, OccupationalTgfb1
atherosclerosisCav1
atopic dermatitisTgfb1
atrial fibrillationCav1
AtrophyRps6kb1
attention deficit hyperactivity disorderCrebbp
autistic disorderCrebbp , Ctnnb1
Autoimmune DiseasesRunx1 , Tgfb2
autoimmune hepatitisTgfb1
autoimmune thrombocytopenic purpuraTgfb1
autosomal dominant mental retardation 53Camk2a
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal dominant polycystic kidney diseaseRps6kb1
background diabetic retinopathyA2m
Barth syndromeFkbp1a
Beckwith-Wiedemann syndromeSptbn1
Behcet's diseaseTgfb1
berylliosisTgfb1
Bile Duct NeoplasmsRunx3
bladder urothelial carcinomaCrebbp , Ctnnb1
bone development diseaseTgfb2
bone diseaseCtgf , Tgfbr2
Bone FracturesRunx1 , Runx2 , Sptbn1 , Tgfbr2
Bone NeoplasmsTgfbr2
brachydactylySmad4
brain diseaseTgfb1
Brain InjuriesRhoa
brain ischemiaCav1 , Creb1 , Ppp1r15a , Tgfb1
Brain NeoplasmsCtnnb1 , Tgfbr2
breast cancerCav1 , Grb2 , Rhoa , Smad4
breast ductal carcinomaPml
Breast NeoplasmsCav1 , Ctnnb1 , Dcn , Ocln , Pdpk1 , Rhoa , Runx3 , Smad2 , Smad4 , Tgfb1 , Wwp1 , Xiap
BurnsA2m , Ocln , Rps6kb1
CachexiaTgfb1
Cafe au lait Spots, MultipleSos1
calcinosisCtnnb1 , Tgfb1
Camurati-Engelmann diseaseTgfb1
carcinomaRhoa , Tgfb1 , Tgfbr2
carcinosarcomaTgfb1
Cardiac FibrosisTgfb1
CardiomegalyA2m , Atf3 , Cav1 , Rhoa , Rps6kb1 , Shc1 , Tgfb1
cardiomyopathyAtf3 , Runx1
Cardiomyopathy, Hypertrophic, FamilialSos1
carotid artery diseaseTgfb1
Carotid Artery InjuriesCtgf , Foxo3
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCtnnb1
celiac diseaseRunx3
Cell Transformation, NeoplasticOcln , Tgfb1
central nervous system diseaseCrebbp
cervix uteri carcinoma in situXiap
Chemical and Drug Induced Liver InjuryCtnnb1 , Shc1 , Tgfbr1
cholangiocarcinomaRunx3 , Smad4 , Tgfb1 , Tgfbr2
cholangitisTgfb2
chorioamnionitisTgfb1
choroid plexus carcinomaFoxo3
Chromosomal InstabilityPpp2r2a
chronic obstructive pulmonary diseaseCtgf , Foxo3 , Smad4 , Tgfb1
CicatrixSmad4
clear cell adenocarcinomaDaxx
cleft palateNedd4l , Tgfb1 , Tgfb2 , Tgfb3
cleft soft palateTgfbr2
cleidocranial dysplasiaRunx2
Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies OnlyRunx2
Cleidocranial Dysplasia, Forme Fruste, with BrachydactylyRunx2
Cocaine-Related DisordersCamk2a , Creb1 , Smad3
Cognition DisordersSmad4
colon adenocarcinomaDaxx , Tgfb1
colon cancerCtnnb1 , Tgfb3 , Tgfbr2
colon carcinomaCtnnb1 , Tgfb1 , Tgfb2
Colonic NeoplasmsA2m , Ctnnb1 , Runx3 , Tgfbr2
colorectal cancerCtnnb1 , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAxin1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad4 , Smad7 , Strap , Tgfb1 , Tgfb2 , Tgfbr1
congenital diaphragmatic herniaTgfb1
congenital generalized lipodystrophy type 3Cav1
Congenital Heart Defects, Multiple Types, 2Tab2
congenital heart diseaseFkbp1a , Tgfb2
congenital hypothyroidismRunx2
Congenital Limb DeformitiesTgfb2
congenital stromal corneal dystrophyDcn
congestive heart failureCtgf , Foxo1 , Pdpk1 , Ppp1ca , Ppp2ca
contact dermatitisCtgf
Copper-Overload CirrhosisSmad2 , Tgfb1
coronary artery diseaseTgfb1
Craniofacial AbnormalitiesCtnnb1 , Runx2 , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2
craniopharyngiomaCtnnb1
Crohn's diseaseOcln , Smad3
Cronkhite-Canada syndromeSmad4
Cutaneous Malignant Melanoma, Susceptibility To, 1Ctnnb1 , Ppp2ca
cutaneous T cell lymphomaRhoa
CyanosisTgfb2
Cystadenoma, SerousDaxx
cystic fibrosisTgfb1
DeafnessSmad4
degenerative disc diseaseTgfb1
demyelinating diseasePpp1r15a
Dermal FibrosisCav1
dermoid cyst of ovaryFoxo3
Developmental DisabilitiesOcln
diabetes mellitusCav1
Diabetic CardiomyopathiesA2m , Ctnnb1
Diabetic NephropathiesCreb1 , Ctgf , Dcn , Tgfb1 , Tgfbr2
diabetic neuropathyCav1 , Tgfb1 , Tgfb2 , Tgfb3
diabetic retinopathyCtgf , Ocln
Diaphyseal Dysplasia 1, ProgressiveTgfb1
diffuse large B-cell lymphomaPdpk1 , Rps6kb1
DiGeorge syndromeTgfbr2
Digestive System NeoplasmsRunx3
Dilatation, PathologicTgfb1
dilated cardiomyopathyCreb1 , Ctnnb1 , Nedd4l , Ppp1ca , Rps6kb1
diseaseCtnnb1
disease by infectious agentXiap
disease of cellular proliferationCtnnb1 , Ocln
Disease ProgressionCtnnb1
Dissecting AneurysmSmad3 , Tgfbr1 , Tgfbr2
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
duodenal ulcerTgfb1
DwarfismCtgf
Ehlers-Danlos syndromeDcn , Tgfb1
EmphysemaPpp1r15a , Ppp2r2a
end stage renal failureTgfb1
endodermal sinus tumorCtnnb1
Endometrial NeoplasmsCtnnb1 , Dcn , Foxo3 , Grb2 , Runx3 , Smad2 , Smad3 , Smad4 , Smad7 , Tgfbr3
Endometrioid CarcinomasCtnnb1 , Daxx
endometriosisNedd4l , Runx1 , Tgfb2
endomyocardial fibrosisCtgf , Tgfb1
eosinophilic esophagitisTgfb1
epilepsyTgfb1
esophageal cancerTgfbr2
esophageal carcinomaCtnnb1 , Rhoa , Smad4
Esophageal NeoplasmsCtnnb1 , Rhoa , Runx3 , Smad4 , Tgfbr2 , Xiap
esophagus adenocarcinomaSmad4
esophagus squamous cell carcinomaCrebbp , Ctnnb1 , Fkbp1a
essential thrombocythemiaTgfb1
exfoliation syndromeCav1
Experimental ArthritisA2m , Arrb2 , Tgfbr2
Experimental Autoimmune EncephalomyelitisA2m , Foxo3 , Rhoa , Tgfb1 , Tgfb2
Experimental Autoimmune MyocarditisCav1
Experimental Autoimmune NeuritisCav1 , Rhoa
Experimental ColitisSmad4
Experimental Diabetes MellitusAtf3 , Cav1 , Ctgf , Dcn , Foxo3 , Rhoa , Tgfb1 , Tgfb2
Experimental Liver CirrhosisA2m , Arrb2 , Atf3 , Cav1 , Ctgf , Fkbp1a , Rhoa , Skil , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16
extrahepatic cholestasisCtgf , Map3k7 , Tgfb1
Exudative vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Eye AbnormalitiesTgfb2 , Tgfbr2
facioscapulohumeral muscular dystrophyDcn
factor VIII deficiencyTgfb1
familial hyperlipidemiaShc1 , Tgfb1
familial partial lipodystrophyCav1
Familial Thoracic Aortic Aneurysm 1Tgfbr2
Familial Thoracic Aortic Aneurysm 3Tgfbr2
FatigueTgfbr2
fatty liver diseaseCreb1 , Shc1
Female InfertilityCtgf
Femur Head NecrosisA2m
Ferguson-Smith tumorTgfbr1
FeverA2m , Ctgf
Fibromatosis, AggressiveCtgf
Fibromatosis, Gingival, 1Sos1
FibrosisCtgf , Dcn , Rhoa , Tgfb1
focal segmental glomerulosclerosisCtgf , Tgfb1
follicular lymphomaCrebbp
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
Gallbladder NeoplasmsRunx3 , Tgfb1
gastric adenocarcinomaCrebbp , Ctnnb1 , Rhoa , Smad4
gastric ulcerFoxo4
Gastrointestinal NeoplasmsSmad4
gastrointestinal stromal tumorTgfbr2
genetic diseaseCav1 , Crebbp , Ctnnb1 , Rhoa , Smad2 , Smad4 , Sos1 , Tgfb2 , Tgfbr2
Germ Cell and Embryonal NeoplasmsRhoa
gestational diabetesDcn
gingival fibromatosisSos1
glaucomaCrebbp , Tgfb2
glioblastoma multiformeCrebbp , Pml , Runx1 , Runx3
granulosa cell tumorCtnnb1
Growth Mental Deficiency Syndrome of MyhreSmad4
head and neck squamous cell carcinomaCrebbp , Ctnnb1 , Rhoa , Smad4
Hearing Loss, Cisplatin-InducedCamk2a
heart diseaseA2m , Ppp2ca , Tgfb1
Heavy Metal ToxicityDaxx
hemolytic anemiaA2m
HemorrhageCav1
hepatic veno-occlusive diseaseOcln
Hepatitis B, ChronicCtgf
Hepatitis, ChronicShc1 , Smad2 , Tgfb1
hepatoblastomaCtnnb1
Hepatoblastoma Caused By Somatic MutationCtnnb1
hepatocellular adenomaA2m , Ctnnb1
hepatocellular carcinomaA2m , Axin1 , Crebbp , Ctnnb1 , Dynlrb1 , Runx3 , Shc1 , Smad2 , Smad4 , Tgfb1 , Tgfbr2
HepatomegalyCamk2a
Hereditary Desmoid DiseaseCtnnb1
hereditary hemorrhagic telangiectasiaSmad4
Hereditary Hemorrhagic Telangiectasia, Type 1Smad4 , Tgfb1
Hereditary Neoplastic SyndromesCamk2a , Ppp2ca , Smad4
Hernias, Diaphragmatic, CongenitalCtgf , Rhoa
Hirschsprung Disease 1Crebbp , Tgfb2
Hirschsprung's diseaseTgfb2
Histiocytoma, Angiomatoid FibrousCreb1
holoprosencephalyCreb1 , Foxh1
holoprosencephaly 1Foxh1
Holt-Oram syndromeTgfb2
Human InfluenzaAtf3
Huntington's diseaseCreb1 , Crebbp
HyperalgesiaCamk2a , Ppp2ca
hyperglycemiaShc1
hyperinsulinismRps6kb1
hyperkalemic periodic paralysisSmurf2
HyperoxaluriaRunx2
HyperoxiaTgfb1
HyperplasiaCav1 , Tgfb1 , Tgfbr2
hypertensionArrb2 , Cav1 , Ctgf , Nedd4l , Rhoa , Rps6kb1 , Tgfb1 , Tgfb3
Hypertensive NephropathyShc1
hypertrophic cardiomyopathyCav1 , Ctnnb1 , Tgfb1 , Tgfb3
Hypertrophy, Left VentricularCtgf , Foxo3 , Rhoa , Rps6kb1 , Shc1
Hypertrophy, Right VentricularTgfb1
HypoalbuminemiaA2m
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
hypoglycemiaCreb1
HypoproteinemiaRps6kb1
hypospadiasAtf3
hypothyroidismCav1
Hypoxia-Ischemia, BrainDaxx , Foxo3
IgA glomerulonephritisTgfb1
Immunoblastic LymphadenopathyRhoa
imperforate anusCtnnb1
impotenceTgfb1
in situ carcinomaCtnnb1 , Runx3
Infant, Newborn, DiseasesTgfb1
InflammationA2m , Camk2a , Tgfb1
inflammatory bowel diseaseRunx3 , Tgfb1
inguinal herniaTgfbr2
Insulin ResistanceFoxo1 , Shc1
insulinomaTgfb1
intellectual disabilityCamk2a
interstitial lung diseaseTgfb1
interstitial nephritisDcn
Intestinal NeoplasmsCtnnb1
Intestinal Reperfusion InjuryPpp1r15a
Intimal HyperplasiaFoxo3
invasive ductal carcinomaSmad4
invasive lobular carcinomaCtnnb1
juvenile myelomonocytic leukemiaRunx1
juvenile polyposis syndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
juvenile rheumatoid arthritisSmad3
keratoconusFoxo1
kidney diseaseTgfb1 , Tgfbr1 , Tgfbr2
Kidney Reperfusion InjuryDaxx
large cell carcinomaStrap
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
left ventricular noncompactionTgfb3 , Ywhae
leiomyomaCav1 , Smad3 , Tgfbr1
leukemiaDaxx
Leukemia, ExperimentalRunx1
limited sclerodermaCav1
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
Lipoyltransferase 1 DeficiencyTgfbr2
liver cancerAxin1 , Crebbp , Ctnnb1
liver cirrhosisA2m , Ctgf , Ctnnb1 , Smad3 , Tgfb1 , Tgfbr1
liver neoplasmAtf3 , Ctnnb1 , Dact2
Liver Neoplasms, ExperimentalArrb2 , Ctnnb1 , Pml , Ppp2ca , Tgfb1
localized sclerodermaTgfb1
Loeys-Dietz syndromeSmad3 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Loeys-Dietz Syndrome, Type 2ATgfbr1
low tension glaucomaCav1
lung adenocarcinomaCrebbp , Ctnnb1 , Foxo3 , Rhoa , Smad4 , Sos1
lung diseaseA2m , Ctgf , Tgfb1
Lung NeoplasmsA2m , Ctgf , Ctnnb1 , Runx3 , Strap , Tgfb1 , Tgfbr2
lung small cell carcinomaCrebbp
lung squamous cell carcinomaCrebbp , Ctnnb1
Lymphatic MetastasisCav1 , Ctnnb1 , Pdpk1 , Rhoa , Smad4
lymphoid leukemiaRunx1
lymphoproliferative syndromeXiap
Lynch syndromeSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
malignant gliomaCav1 , Dcn
malignant mesotheliomaCtnnb1 , Tgfb2
Mammary Neoplasms, ExperimentalCav1 , Ctnnb1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Xiap
Mandibular NeoplasmsCtnnb1
mantle cell lymphomaCtnnb1
Marfan syndromeTgfbr2
medulloblastomaCrebbp , Ctnnb1 , Foxo3
megakaryocytic leukemiaRunx1
melanomaCav1 , Crebbp , Ctnnb1 , Ppp2ca
membranoproliferative glomerulonephritisCtgf , Tgfbr2
membranous glomerulonephritisA2m , Rhoa
Memory DisordersCreb1
Metabolic SyndromeTgfb1
Metaphyseal Dysplasia with Maxillary Hypoplasia and BrachydactylyRunx2
Metaphyseal Dysplasia with Maxillary Hypoplasia with or without BrachydactylyRunx2
Micronuclei, Chromosome-DefectivePpp2r2a
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityTgfbr2
middle cerebral artery infarctionAtf3 , Camk2a , Runx1
migraineTab2 , Tgfbr2
Miller-Dieker lissencephaly syndromeYwhae
morphine dependenceCreb1
Mucinous CystadenomaDaxx
Multiple AbnormalitiesCav1 , Crebbp , Ctnnb1 , Smad2 , Sptbn1
multiple myelomaRunx1 , Tgfb1
multiple sclerosisCav1 , Rhoa
Multisystem Autoimmune Disease, with Facial DysmorphismItch
Muscle SpasticityCrebbp
muscular atrophyCtnnb1 , Rps6kb1
muscular diseaseSmad4 , Tgfb1
Musculoskeletal AbnormalitiesTgfb2
myelodysplastic syndromeCrebbp , Runx1
myelofibrosisTgfb1
myeloid neoplasmRunx1
myocardial infarctionCreb1 , Ctgf , Dcn , Rps6kb1 , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2
Myocardial IschemiaDcn , Eif2a , Ppp2ca
Myocardial Reperfusion InjuryArrb2 , Atf3 , Rhoa , Smad3 , Smad4 , Tgfb1 , Xiap
Nasal PolypsTgfb1
NecrosisCtgf
NeointimaFoxo4
Neoplasm InvasivenessCtnnb1 , Rhoa , Tgfb1
Neoplasm MetastasisCav1 , Ctnnb1 , Daxx , Dcn , Pml , Rhoa , Tgfb1 , Tgfbr1 , Tgfbr2 , Ywhae
Neoplasms, Second PrimaryPml
nephritisSmad7
nephroblastomaCtnnb1
Nephrogenic Fibrosing DermopathyCav1
nephrolithiasisTgfb1
nephrotic syndromeA2m , Tgfb1
Nerve DegenerationCtnnb1
nervous system diseaseAtf3
NeuralgiaTgfb1
Neurodevelopmental DisordersCtnnb1
neuroendocrine tumorDaxx
neuronal ceroid lipofuscinosis 1Rps6kb1
neuronal ceroid lipofuscinosis 8Tgfbr2
No-Reflow PhenomenonCtnnb1
non-Hodgkin lymphomaRhoa
non-small cell lung carcinomaAtf3 , Foxo3 , Pdpk1
nonalcoholic fatty liver diseaseTgfb1
nonsyndromic deafnessTgfb3
Noonan Like SyndromeSos1
Noonan syndromeSos1
Noonan syndrome 3Sos1
Noonan syndrome 4Sos1
obesityCav1 , Dcn , Foxo3 , Rhoa , Rps6kb1 , Tgfb1
obstructive lung diseaseA2m
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
open-angle glaucomaCav1
Optic Nerve InjuriesRhoa
oral submucous fibrosisTgfb1
Ossification, HeterotopicRunx2 , Smad4
osteoarthritisCav1 , Runx2 , Smad3
Osteoarthritis, KneeCtnnb1
osteochondrodysplasiaTgfb1 , Tgfb2 , Tgfbr1
osteogenesis imperfectaSmad4
osteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
osteosarcomaRunx2
ovarian cancerCtnnb1
Ovarian NeoplasmsAtf3 , Cav1 , Ctgf , Ctnnb1 , Rhoa , Runx3 , Smad2 , Smad4 , Smad7 , Xiap
ovary epithelial cancerDaxx
Paget's disease of bonePml
pancreatic adenocarcinomaCtnnb1 , Smad4
pancreatic cancerCtnnb1 , Daxx , Runx3 , Smad3 , Smad4 , Smurf1 , Tgfb1 , Tgfbr2
pancreatic carcinomaSmad4
pancreatic ductal carcinomaTgfb1 , Tgfbr2
pancreatic endocrine carcinomaDaxx
Pancreatic Islet Cell TumorsDaxx
papillomaTgfb1
paraplegiaFoxo4
Paraquat LungSkil , Smad7 , Tgfb1
Parasitic Liver DiseasesSmad4
Parkinson's diseaseA2m , Ctgf , Ppp2ca
Parkinsonian DisordersFkbp1a
peripheral nervous system diseaseAtf3
peripheral T-cell lymphomaRhoa
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsCtnnb1
peritonitisA2m
periventricular nodular heterotopiaNedd4l
Periventricular Nodular Heterotopia 7Nedd4l
Periventricular Nodular Heterotopia with Syndactyly, Cleft Palate and Developmental DelayNedd4l
Peyronie's diseaseTgfb1
Phyllodes TumorCtnnb1
Pick's diseaseCreb1
pilomatrixomaCtnnb1
Platelet Disorder, Familial, with Associated Myeloid MalignancyRunx1
pleomorphic xanthoastrocytomaCav1 , Smurf1
pleural diseaseTgfb1
pneumoniaTgfb1
polycystic ovary syndromeRunx3 , Tab1
portal hypertensionArrb2
Posterior Leukoencephalopathy SyndromeTgfb1
pre-malignant neoplasmSmad3 , Smad4
precursor B lymphoblastic lymphoma/leukemiaCtgf , Runx1
precursor lymphoblastic lymphoma/leukemiaCrebbp , Runx1
precursor T-lymphoblastic lymphoma/leukemiaRunx1
Premature AgingFoxo1
Prenatal Exposure Delayed EffectsCtgf
primary biliary cirrhosisCtgf , Rps6kb1
primary open angle glaucomaCav1
primary pulmonary hypertensionCav1 , Smad4
Progressive Osseous HeteroplasiaCtnnb1
prostate adenocarcinomaCtnnb1 , Grb2 , Pdpk1 , Smad4
prostate cancerAtf3 , Ctnnb1 , Grb2 , Pdpk1 , Ppp2ca , Skil , Sos1 , Tgfbr2 , Tgfbr3
prostate carcinoma in situSmad4
Prostatic NeoplasmsAtf3 , Cav1 , Crebbp , Ctnnb1 , Daxx , Foxo1 , Foxo3 , Map3k7 , Pml , Ppp2ca , Ppp2r2a , Runx1 , Smad3 , Smad4 , Tgfb1 , Tgfbr2 , Wwp1 , Xiap
prostatitisSmad4
proteinuriaRhoa , Tgfb1
pseudo-TORCH syndrome 1Ocln
psoriasisCav1 , Runx3 , Tgfb1
psoriatic arthritisRunx2
pulmonary embolismCtgf
pulmonary emphysemaTgfb1
pulmonary fibrosisCav1 , Ctgf , Skil , Smad4 , Smad7 , Tgfb1 , Tgfbr2
pulmonary hypertensionCav1 , Ctgf , Foxo1 , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
Pulmonary Hypertension, Primary, 3Cav1
pulmonary sarcoidosisTgfb1
pulmonary valve stenosisSos1
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalCtgf
Radiation PneumonitisTgfb1
RASopathiesSos1
renal cell carcinomaCav1 , Ctnnb1 , Smad2 , Smad4 , Tgfb1 , Xiap
renal fibrosisArrb2
Reperfusion InjuryCav1 , Eif2a , Tgfbr2
Respiratory System AbnormalitiesTgfb2 , Tgfb3
restrictive cardiomyopathyCtgf
retinal diseaseOcln
rheumatoid arthritisA2m , Ctgf , Foxo3 , Runx1 , Runx2
rhinitisTgfb1
Rubinstein-Taybi syndromeCrebbp
sarcoidosisTgfb1
SarcopeniaCav1 , Foxo4
schizophreniaCreb1 , Pml
sciatic neuropathyCav1 , Creb1 , Runx1
scoliosisCrebbp
seminomaSmad4
Sensenbrenner syndromeTgfb3
SepsisA2m , Tgfb1
Sezary's diseaseCrebbp
sickle cell anemiaTgfb1
Sjogren's syndromeTgfb1
skin diseaseSkil
Skin NeoplasmsCtnnb1 , Tgfb1 , Tgfbr1
Smith-Magenis syndromeGrb2 , Rps6kb1 , Smurf2
spina bifidaCrebbp
Spina Bifida CysticaRunx1
Spinal Cord InjuriesCav1 , Foxo3 , Ppp1r15a , Smurf1 , Tgfb1 , Tgfb2
SplenomegalyOcln
SpondylarthritisRunx2
squamous cell carcinomaCav1 , Crebbp , Smurf2 , Tgfb1
squamous cell neoplasmStrap
status epilepticusFoxo3
Stevens-Johnson syndromeCav1 , Ctnnb1 , Pml
Stomach NeoplasmsCav1 , Ctnnb1 , Rhoa , Runx3 , Smad4 , Sptbn1
Stomatognathic System AbnormalitiesRunx2
StrokeCtnnb1 , Nedd4l , Ppp1r15a , Tgfb1
syndactylyNedd4l
systemic sclerodermaCav1 , Ctgf , Tgfbr1
T-Cell LymphomaRhoa , Runx1
temporal lobe epilepsyFoxo3
tendinitisCtgf
teratomaCtnnb1
tethered spinal cord syndromeCrebbp
tetralogy of FallotFoxh1
thalassemiaPpp1r15a
Therapy-related Acute Myeloid LeukemiaRunx1
thoracic aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
thrombocytopeniaRunx1 , Tgfb1
Thumb DeformityCrebbp
Tooth AbnormalitiesRunx2
toxic shock syndromeA2m
tracheal stenosisTgfb1
transient cerebral ischemiaCamk2a , Cav1 , Creb1 , Daxx , Ppp1r15a
Transient Myeloproliferative Disorder of Down SyndromeRunx1
transitional cell carcinomaCav1 , Crebbp , Ctnnb1 , Daxx , Smad4
Transplant RejectionArrb2
trypanosomiasisA2m
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeSmad4
type 1 diabetes mellitusFoxo1 , Tgfb1
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusArrb2 , Atf3 , Ctgf , Dcn , Foxo1 , Ppp2ca , Smad4 , Tgfb1 , Tgfbr2
uremiaRunx2 , Tgfb1 , Tgfbr1
ureteral obstructionCtgf , Skil , Tgfb1 , Tgfb2
urethral obstructionTgfb1
urinary bladder cancerCav1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad2 , Smad4 , Tgfbr1
Urogenital AbnormalitiesTgfb2
Urologic NeoplasmsRhoa
urticariaTgfb1
Usher syndromeTgfb2
Uterine Cervical NeoplasmsCrebbp , Ctnnb1 , Smad2 , Smad4 , Sos1 , Xiap
Uterine NeoplasmsCtnnb1 , Smad3 , Sos1
uveitisTgfb1
Vascular CalcificationCtnnb1
vasculogenic impotenceTgfbr2
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
ventricular septal defectTgfb3
visceral heterotaxyFoxh1
vitiligoTgfb1
Wallerian DegenerationTgfb1 , Tgfb2
Weight GainCav1 , Sptbn1
Wilson diseaseA2m , Camk2a
withdrawal disorderCreb1
Wolff-Parkinson-White syndromeMap3k7 , Tgfbr2 , Wwp1
Wounds and InjuriesDcn , Tgfb1 , Tgfb2 , Tgfb3
X-linked lymphoproliferative syndrome 1Xiap
X-linked lymphoproliferative syndrome 2Xiap
Pathway Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a , Smad2 , Smad3
acute myeloid leukemia pathwayGrb2 , Pml , Rps6kb1 , Runx1 , Sos1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp2ca
adenosine signaling pathwayCreb1 , Pard6a , Pdpk1
aldosterone signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayAxin1 , Ctnnb1
Alzheimer's disease pathwayA2m
amyotrophic lateral sclerosis pathwayDaxx
androgen signaling pathwayCrebbp
angiotensin II signaling pathwayPdpk1
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayXiap
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
B cell receptor signaling pathwayGrb2 , Sos1
basal cell carcinoma pathwayAxin1 , Ctnnb1
Bone morphogenetic proteins signaling pathwayBambi , Map3k7 , Ppp1ca , Ppp1r15a , Smad4 , Smad7 , Smurf1 , Smurf2 , Tab1 , Tab2 , Xiap , Zfyve16
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2 , Rhoa
calcium/calcium-mediated signaling pathwayCamk2a
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Ppp2ca
cell cycle pathway, mitoticCrebbp , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Ywhae
ceramide signaling pathwayEif2a , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
Chagas disease pathwayPpp2ca , Ppp2cb , Ppp2r2a , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayArrb2 , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1
chronic myeloid leukemia pathwayGrb2 , Runx1 , Shc1 , Smad3 , Smad4 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
coagulation cascade pathwayA2m
colorectal cancer pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
complement system pathwayA2m
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
dopamine signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCtnnb1 , Rhoa
eicosanoid signaling pathwayArrb2 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayArrb2 , Cav1 , Itch , Nedd4l , Pard6a , Pml , Rhoa , Smad2 , Smad3 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Wwp1 , Zfyve16 , Zfyve9
endometrial cancer pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
endoplasmic reticulum stress - the unfolded protein response pathwayEif2a
Endoplasmic Reticulum-associated degradation pathwayPpp1r15a
endothelin signaling pathwayRhoa
Entamoebiasis pathwayTgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Map3k7 , Rhoa
epidermal growth factor/neuregulin signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayGrb2 , Shc1 , Sos1
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayGrb2 , Sos1
Fc gamma receptor mediated signaling pathwayRps6kb1
fibroblast growth factor signaling pathwayCamk2a , Grb2 , Pdpk1 , Runx2 , Shc1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1 , Ppp1ca
forkhead class A signaling pathwayCreb1 , Crebbp
glioma pathwayCamk2a , Grb2 , Shc1 , Sos1
glycogen biosynthetic pathwayPpp1ca
glycogen degradation pathwayPpp1ca
glypican signaling pathwaySmad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayCamk2a , Grb2 , Sos1
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Shc1 , Sos1
Hedgehog signaling pathwayArrb2 , Crebbp , Tgfb2
hepatitis C pathwayGrb2 , Ocln , Ppp2ca , Ppp2cb , Ppp2r2a , Sos1
histamine signaling pathway, immunologicalCreb1 , Ppp1ca
histone modification pathwayCrebbp , Daxx
Huntington's disease pathwayCreb1 , Crebbp
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayCreb1 , Crebbp , Smad3 , Smad4
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A pathwayCrebbp , Pml
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhae
insulin signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
insulin-like growth factor signaling pathwayGrb2 , Pdpk1 , Rps6kb1 , Shc1 , Sos1 , Ywhae
interleukin-1 signaling pathwayMap3k7 , Tab1 , Tab2
interleukin-2 signaling pathwayGrb2 , Rhoa , Shc1 , Sos1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Shc1
interleukin-4 signaling pathwayGrb2 , Rps6kb1 , Shc1
interleukin-5 signaling pathwayGrb2
interleukin-6 signaling pathwayA2m , Foxo1 , Grb2 , Sos1
intrinsic apoptotic pathwayXiap
Jak-Stat signaling pathwayCrebbp , Grb2 , Sos1
kallikrein-kinin cascade pathwayA2m
kinin signaling pathwayArrb2
Leishmaniasis pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionPpp2ca , Ppp2cb
long term potentiationCamk2a , Crebbp , Ppp1ca
luteinizing hormone signaling pathwayCreb1 , Ppp1ca
malaria pathwayTgfb1 , Tgfb2 , Tgfb3
measles pathwayMap3k7
mitochondria transport pathwayDynlrb1
mitogen activated protein kinase signaling pathwayArrb2 , Daxx , Grb2 , Map3k7 , Shc1 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r2a
mTOR signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Rhoa
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayCamk2a , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1 , Ywhae
NOD-like receptor signaling pathwayMap3k7 , Xiap
non-small cell lung carcinoma pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
Notch signaling pathwayCrebbp , Itch
nuclear factor kappa B signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p38 MAPK signaling pathwayMap3k7 , Tab1 , Tab2
p53 signaling pathwayCrebbp , Daxx , Ppp2ca
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Pdpk1 , Rhoa
phosphatidylinositol 3-kinase-Akt signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
platelet-derived growth factor signaling pathwayCav1 , Grb2 , Ppp2ca , Rhoa , Shc1 , Sos1 , Ywhae
prostate cancer pathwayCreb1 , Crebbp , Ctnnb1 , Foxo1 , Grb2 , Pdpk1 , Sos1
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1
Ras family mediated signaling pathwaySos1
renal cell carcinoma pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k7
reverse cholesterol transport pathwayCav1
rheumatoid arthritis pathwayTgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayRhoa
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayStrap
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1 , Ppp1ca
small cell lung carcinoma pathwayXiap
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa , Tgfb1
T cell receptor signaling pathwayGrb2 , Map3k7 , Rhoa , Sos1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayShc1
thyroid cancer pathwayCtnnb1
Toll-like receptor signaling pathwayMap3k7 , Tab1 , Tab2
toxoplasmosis pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3 , Xiap
transforming growth factor-beta Smad dependent signaling pathwayA2m , Arrb2 , Atf3 , Axin1 , Bambi , Camk2a , Cav1 , Creb1 , Crebbp , Ctgf , Ctnnb1 , Dact2 , Daxx , Dcn , Dynlrb1 , Eif2a , Fkbp1a , Foxh1 , Foxo1 , Foxo3 , Foxo4 , Grb2 , Itch , Map3k7 , Nedd4l , Ocln , Pard6a , Pdpk1 , Pml , Ppp1ca , Ppp1r15a , Ppp2ca , Ppp2cb , Ppp2r2a , Rhoa , Rnf111 , Rps6kb1 , Runx1 , Runx2 , Runx3 , Shc1 , Skil , Smad2 , Smad3 , Smad4 , Smad7 , Smurf1 , Smurf2 , Sos1 , Sptbn1 , Strap , Tab1 , Tab2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tgfbr3 , Wwp1 , Xiap , Ywhae , Zfyve16 , Zfyve9
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Dcn , Ppp2ca , Ppp2cb , Rhoa , Rps6kb1 , Smad2 , Smad3 , Smad4 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16 , Zfyve9
tuberculosis pathwayCamk2a , Creb1 , Crebbp , Rhoa , Tgfb1 , Tgfb2 , Tgfb3
tumor necrosis factor mediated signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
type II interferon signaling pathwayCamk2a , Crebbp , Smad7
ubiquitin/proteasome degradation pathwayItch , Nedd4l , Pml , Smurf2 , Wwp1 , Xiap
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1 , Grb2 , Pdpk1 , Rhoa
vasopressin signaling pathway via receptor type 2Creb1
visual phototransduction pathwayArrb2
Wnt signaling pathwayAxin1 , Camk2a , Crebbp , Ctnnb1 , Map3k7 , Ppp2ca , Ppp2cb , Rhoa , Smad2 , Smad3 , Smad4
Wnt signaling, canonical pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
Wnt signaling, non-canonical pathwayArrb2 , Camk2a , Map3k7 , Rhoa , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRhoa
Phenotype Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Phenotype TermsGene Symbols
cardiac hypertrophyCrebbp
liver fibrosisSmad3

References Associated with the transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: