C-JUN N-TERMINAL KINASES MAPK SIGNALING PATHWAY (PW:0000313)

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Description

The c-Jun N-terminal kinase pathway (Jnk), known as a stress activated protein kinase pathway (SAPK), responds to inflammatory cytokines and various stresses and to a lesser degree to growth factors. Jnk displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier (here Jnk1-3 represented by Mapk8-10) is activated by phosphorylation of threonine and tyrosine residues within the conserved TPY motif in the activation loop by dual specificity k

Pathway Diagram:

Elsevier Inc. upstream c-Jun other upstream c-Jun Rac1 --+> Map3k4 Rac1 --+> Map3k1 Rac1 --+> Map3k11 Cdc42 --+> Map3k4 Map3k4 Cdc42 --+> Map3k1 Cdc42 --+> Map3k11 effectors/adapters --+> Cdc42 effectors/adapters --+> Rac1 stress conditions --+> Map3k5 Mapk10 Mapk9 Mapk8 Map2k7 Map2k4 Map3k5 --+> Map2k4 Map3k5 Traf2 Cdc42 Rac1 Map3k11 Map3k1 other Jnk Map3k Jnk scaffolds ---- Map2k4 adapters ---- Traf2 adapters ---- other upstream c-Jun Mapk9 ---> Jnk cytoplasmic/other targets Mapk9 ---> Jnk nuclear targets Map2k7 --+> Mapk8 Map2k4 --+> Mapk9 effectors/adapters ---- upstream c-Jun effectors/adapters stress conditions adapters Traf2 --+> Map3k5 Map2k7 --+> Mapk9 Map2k4 --+> Mapk8 Jnk scaffolds ---- Mapk8 Map3k11 --+> Map2k4 Map3k4 --+> Map2k4 Map3k1 --+> Map2k4 Map3k4 --+> Map2k7 Jnk scaffolds ---- other Jnk Map3k Mapk8 ---> Jnk cytoplasmic/other targets Jnk Dusp members ---| Mapk8 Jnk Dusp members ---| Mapk9 Map3k11 --+> Map2k7 Mapk8 ---> Jnk nuclear targets Jnk scaffolds Jnk Dusp members Jnk nuclear targets Jnk cytoplasmic/other targets other Jnk Map3k ---> Map2k4 other Jnk Map3k --+> Map2k7 Map3k5 --+> Map2k7 Map3k1 --+> Map2k7
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Genes in Pathway:

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c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:2293876
RGD:2293879
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:2293881
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:2293881
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:2293881
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:2314491
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:2293881
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293875
RGD:2298708
RGD:2298577
RGD:2298561
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2293875
RGD:2298577
RGD:2298567
RGD:2298561
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:2293879
RGD:2293875
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:2293875
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:2293876
RGD:2298577
RGD:2298567
RGD:2293875
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:2293875
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2293879
RGD:2293875
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293879
RGD:2293875
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:2293879
RGD:2293875
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293875
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 6 105,455,461 105,518,974 RGD:2293875
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:2293875
RGD:2298567
RGD:2298561
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:2293875
RGD:2298577
RGD:2298561
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:2293880
RGD:1579811
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293880
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:2293880
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2293875
RGD:2298577
RGD:2298561
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293876
RGD:2293879
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:11534984
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupJnk Dusp membersdual specificity phosphatases for Jnk Mapks
Gene GroupJnk scaffoldsmembers of the Jip family

Pathway Gene Annotations

Disease Annotations Associated with Genes in the c-Jun N-terminal kinases MAPK signaling pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
abdominal aortic aneurysmMapk8
acute kidney failureSpp1
Acute Liver FailureMapk8
adenocarcinomaSpp1
Adrenal Gland NeoplasmsCdc42
AlbuminuriaSpp1
Alcoholic Liver DiseasesSpp1
allergic contact dermatitisSpp1
allergic hypersensitivity diseaseSpp1
Alzheimer's diseaseCdc42 , Mapk10 , Mapk8 , Mapk9
Amyloid NeuropathiesDusp1
AneurysmSpp1
Angina PectorisSpp1
Animal Disease ModelsMapk8 , Mapk9
anti-basement membrane glomerulonephritisDusp1 , Mapk8 , Rapgef1 , Spp1
arteriosclerosisDusp1 , Mapk9
asbestosisSpp1
atopic dermatitisMapk8
autism spectrum disorderMapk8ip2
autosomal dominant mental retardation 48Rac1
autosomal dominant polycystic kidney diseaseSpp1
biliary atresiaSpp1
bipolar disorderCdc42
Brain DeathMap2k4
brain ischemiaMapk8
Brain NeoplasmsSpp1
Breast NeoplasmsDusp1 , Map2k4 , Map2k7 , Map3k1 , Spp1
calcinosisSpp1
carcinomaCdc42
Cardiac ArrhythmiasMap2k4
CardiomegalyMapk8 , Rac1 , Spp1
CardiotoxicityRac1
Carotid Artery InjuriesDusp1
Cell Transformation, NeoplasticMapk8 , Rac1
Cerebral HemorrhageSpp1
Chemical and Drug Induced Liver InjurySpp1
chronic obstructive pulmonary diseaseMap2k4 , Mapk8
colitisDusp1
colon adenocarcinomaRac1
colon adenomaRac1
Colonic NeoplasmsMapk8 , Mapk9
colorectal adenocarcinomaMapk8
colorectal adenomaMapk8
colorectal cancerRac1
congestive heart failureMap2k7 , Rac1
contact dermatitisDusp1
coronary artery diseaseSpp1
coronary restenosisSpp1
Cutaneous Malignant Melanoma, Susceptibility To, 1Rac1
diabetes mellitusRac1
Diabetic CardiomyopathiesSpp1
diabetic encephalopathyDusp1
Diabetic NephropathiesSpp1
dilated cardiomyopathyRac1
disease of cellular proliferationSpp1
Drug-Related Side Effects and Adverse ReactionsSpp1
encephalomyelitisSpp1
Endometrial NeoplasmsMap3k4
Endometrioid CarcinomasSpp1
endometriosisDusp1
Esophageal NeoplasmsMap3k3
Experimental ArthritisCdc42
Experimental Autoimmune EncephalomyelitisDusp10
Experimental Autoimmune NeuritisSpp1
Experimental Diabetes MellitusDusp1 , Spp1
Experimental Liver CirrhosisDusp16 , Spp1
Experimental NeoplasmsSpp1
extrahepatic cholestasisMap3k7 , Mapk8 , Mapk9
fatty liver diseaseMapk8
Fetal Growth RetardationDusp1
fibrosarcomaCdc42
FibrosisMap2k7 , Spp1
focal segmental glomerulosclerosisSpp1
Foreign-Body ReactionSpp1
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
Generalized EpilepsyMapk10
genetic diseaseCdc42 , Map3k1
glomerulonephritisSpp1
glomerulosclerosisSpp1
glucose intoleranceDusp1
head and neck squamous cell carcinomaRac1
heart diseaseSpp1
heart valve diseaseSpp1
HepatitisSpp1
Hepatitis C, ChronicSpp1
hepatocellular carcinomaRac1 , Spp1
human immunodeficiency virus infectious diseaseCdc42
Huntington's diseaseDusp1
HyperalgesiaDusp1 , Mapk8 , Mapk9
hypertensionDusp1 , Mapk8
Hypertrophy, Left VentricularDusp1 , Rac1
InflammationDusp10 , Spp1
Intestinal NeoplasmsMapk8
invasive ductal carcinomaMap2k4
ischemiaMapk9
juvenile rheumatoid arthritisDusp1
Kidney CalculiSpp1
kidney diseaseSpp1
kidney failureSpp1
Kuhnt-Junius degenerationMapk8
Laryngeal NeoplasmsSpp1
leishmaniasisDusp1
Lennox-Gastaut syndromeMapk10
LeukoencephalopathiesSpp1
liver cirrhosisSpp1
liver diseaseRac1
Liver Neoplasms, ExperimentalSpp1
Liver Reperfusion InjuryMapk8
Loeys-Dietz Syndrome 4Dusp10
Lung NeoplasmsMap2k7 , Spp1
major depressive disorderDusp1
malariaSpp1
malignant gliomaSpp1
Mammary Neoplasms, AnimalCdc42
Mammary Neoplasms, ExperimentalCdc42 , Dusp1 , Map2k7 , Spp1
melanomaMap3k9 , Rac1 , Spp1
mesangial proliferative glomerulonephritisRapgef1
MesotheliomaSpp1
Microphthalmia, Syndromic 1Map3k1
microvillus inclusion diseaseCdc42
Monoclonal B-Cell LymphocytosisRapgef1
Multiple AbnormalitiesCdc42
multiple myelomaSpp1
multiple sclerosisSpp1
myocardial infarctionSpp1
Myocardial IschemiaDusp1
Myocardial Reperfusion InjuryMapk8 , Spp1
myocarditisSpp1
NecrosisCdc42
Neoplasm MetastasisMapk9 , Rac1 , Spp1
Neoplasms, Cystic, Mucinous, and SerousSpp1
Neovascularization, PathologicSpp1
nephroblastomaMap3k4
neuroblastomaMap2k4 , Map2k7
non-small cell lung carcinomaSpp1
nonalcoholic fatty liver diseaseMapk8
Noonan Like SyndromeCdc42
obesityDusp1
OsteolysisSpp1
otitis mediaDusp1
Ovarian NeoplasmsDusp1 , Map2k4 , Map2k7 , Spp1
Oxygen-Induced RetinopathyMapk8
pancreas diseaseSpp1
pancreatic cancerCdc42 , Map2k4 , Spp1
pancreatitisDusp1 , Dusp10
papillomaMap2k4
Pleural NeoplasmsSpp1
pneumoniaSpp1
polycystic ovary syndromeMapk8ip3
portal hypertensionDusp1
pre-malignant neoplasmMap2k7 , Mapk8 , Mapk9
Progressive Osseous HeteroplasiaSpp1
prostate cancerMapk10
prostate carcinoma in situMap2k4 , Map2k7
Prostatic NeoplasmsDusp1 , Map2k4 , Map2k7 , Map3k1 , Map3k7 , Spp1
proteinuriaSpp1
psoriasisDusp1
pulmonary fibrosisSpp1
radiculopathySpp1
rectal neoplasmMapk8
renovascular hypertensionSpp1
Reperfusion InjuryCdc42 , Mapk8 , Mapk8ip3 , Mapk9 , Spp1
Retina Reperfusion InjuryDusp1 , Map2k4
rheumatoid arthritisSpp1
rhinitisCdc42
schizophreniaMap2k7
scrapieSpp1
Skin NeoplasmsMap2k4
Sleep DeprivationMap2k4
Smith-Magenis syndromeMap3k3
Spinal Cord InjuriesCdc42 , Dusp1 , Spp1
squamous cell carcinomaDusp1
Stomach NeoplasmsMapk8 , Spp1
StrokeMapk8
Takenouchi-Kosaki SyndromeCdc42
temporal lobe epilepsyCdc42
Thyroid NeoplasmsSpp1
transient cerebral ischemiaDusp1 , Dusp16 , Map2k4
Trauma, Nervous SystemSpp1
trigeminal neuralgiaMapk8 , Mapk9
tuberculosisSpp1
type 1 diabetes mellitusDusp1
type 2 diabetes mellitusMapk8 , Mapk8ip1 , Mapk9
uremiaSpp1
urinary bladder cancerDusp1 , Map2k4 , Spp1
Urinary CalculiSpp1
Usher syndromeDusp10
Uterine NeoplasmsRac1
Vascular System InjuriesSpp1
Ventricular Dysfunction, LeftRac1
visual epilepsyDusp1 , Spp1
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesSpp1
Pathway Annotations Associated with Genes in the c-Jun N-terminal kinases MAPK signaling pathway
Pathway TermsGene Symbols
adenosine signaling pathwayCdc42 , Map2k7 , Map3k1 , Map3k4 , Mapk8
amyotrophic lateral sclerosis pathwayRac1
angiotensin II signaling pathway via AT2 receptorDusp1
apoptotic cell death pathwayTraf2
Arf family mediated signaling pathwayRac1
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayRac1
Bone morphogenetic proteins signaling pathwayMap3k7
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Dusp19 , Dusp8 , Map2k4 , Map2k7 , Map3k1 , Map3k10 , Map3k11 , Map3k12 , Map3k2 , Map3k3 , Map3k4 , Map3k7 , Map3k9 , Mapk10 , Mapk8 , Mapk8ip1 , Mapk8ip2 , Mapk8ip3 , Mapk9 , Rac1 , Rapgef1 , Spp1 , Traf2
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayCdc42 , Map2k4 , Map3k1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Traf2
Chagas disease pathwayMap2k4 , Mapk10 , Mapk8 , Mapk9
chemokine mediated signaling pathwayCdc42 , Rac1
colorectal cancer pathwayMapk10 , Mapk8 , Mapk9 , Rac1
diabetic nephropathy pathwaySpp1
E-cadherin signaling pathwayCdc42 , Rac1
eicosanoid signaling pathwayRac1
endocytosis pathwayCdc42
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9 , Traf2
endothelin signaling pathwayCdc42 , Mapk8 , Rac1
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k4 , Map3k7 , Mapk8 , Rac1
epidermal growth factor/neuregulin signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
Erk5 MAPK signaling pathwayMap3k2 , Map3k3
erythropoietin signaling pathwayMapk8
FasL mediated signaling pathwayMap2k7 , Map3k1 , Mapk10 , Mapk8 , Mapk9
Fc epsilon receptor mediated signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Fc gamma receptor mediated signaling pathwayCdc42 , Rac1
fibroblast growth factor signaling pathwaySpp1
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCdc42 , Map2k4 , Map2k7 , Map3k1 , Map3k2 , Map3k3 , Map3k4 , Mapk10 , Mapk8 , Mapk9
hepatitis C pathwayMapk10 , Mapk8 , Mapk9 , Traf2
inflammatory response pathwayMapk8
influenza A pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
insulin responsive facilitative sugar transporter mediated glucose transport pathwayRac1 , Rapgef1
insulin secretion pathwayCdc42
insulin signaling pathwayMapk10 , Mapk8 , Mapk9 , Rapgef1
interleukin-1 signaling pathwayMap3k3 , Map3k7 , Mapk8
interleukin-2 signaling pathwayMapk8 , Mapk9
interleukin-6 signaling pathwayMap2k4 , Rac1
kidney disease pathwaySpp1
Leishmaniasis pathwayMap3k7
measles pathwayMap3k7
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Dusp8 , Map2k4 , Map2k7 , Map3k1 , Map3k11 , Map3k12 , Map3k2 , Map3k3 , Map3k4 , Map3k7 , Mapk10 , Mapk8 , Mapk8ip1 , Mapk8ip2 , Mapk8ip3 , Mapk9 , Rac1 , Traf2
mTOR signaling pathwayRac1
myocarditis pathwayRac1
N-cadherin signaling pathwayCdc42 , Mapk8 , Rac1
neurotrophic factor signaling pathwayCdc42 , Map2k7 , Map3k1 , Map3k3 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rapgef1
NOD-like receptor signaling pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9
nuclear factor kappa B signaling pathwayMap3k7
p38 MAPK signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Map3k1 , Map3k10 , Map3k11 , Map3k3 , Map3k4 , Map3k7 , Mapk8ip2 , Rac1 , Traf2
p53 signaling pathwayMapk8 , Mapk9
pancreatic cancer pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayRac1
platelet-derived growth factor signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Reelin signaling pathwayMap2k7 , Map3k11 , Mapk8
renal cell carcinoma pathwayCdc42 , Rac1 , Rapgef1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Traf2
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Map2k4 , Mapk8 , Rac1 , Rapgef1
small cell lung carcinoma pathwayTraf2
sphingosine 1-phosphate signaling pathwayCdc42 , Mapk8 , Rac1
syndecan signaling pathwayMapk8 , Rac1
T cell receptor signaling pathwayCdc42 , Map2k7 , Map3k7 , Mapk9
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Map3k2 , Spp1
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayMap2k4 , Map2k7 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Spp1
toxoplasmosis pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9
Trail mediated signaling pathwayMap2k4 , Map3k1 , Mapk8 , Traf2
transforming growth factor-beta Smad dependent signaling pathwayMap3k7
tuberculosis pathwayMapk10 , Mapk8 , Mapk9
tumor necrosis factor mediated signaling pathwayMap2k7 , Map3k1 , Map3k3 , Map3k7 , Traf2
type 2 diabetes mellitus pathwayMapk10 , Mapk8 , Mapk9
type II interferon signaling pathwayMap3k1 , Map3k11
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayCdc42 , Rac1
Wnt signaling pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, non-canonical pathwayCdc42 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1

References Associated with the c-Jun N-terminal kinases MAPK signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: