C-JUN N-TERMINAL KINASES MAPK SIGNALING PATHWAY (PW:0000313)

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Description

The c-Jun N-terminal kinase pathway (Jnk), known as a stress activated protein kinase pathway (SAPK), responds to inflammatory cytokines and various stresses and to a lesser degree to growth factors. Jnk displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier (here Jnk1-3 represented by Mapk8-10) is activated by phosphorylation of threonine and tyrosine residues within the conserved TPY motif in the activation loop by dual specificity k

Pathway Diagram:

Elsevier Inc. upstream c-Jun other upstream c-Jun Rac1 --+> Map3k4 Rac1 --+> Map3k1 Rac1 --+> Map3k11 Cdc42 --+> Map3k4 Map3k4 Cdc42 --+> Map3k1 Cdc42 --+> Map3k11 effectors/adapters --+> Cdc42 effectors/adapters --+> Rac1 stress conditions --+> Map3k5 Mapk10 Mapk9 Mapk8 Map2k7 Map2k4 Map3k5 --+> Map2k4 Map3k5 Traf2 Cdc42 Rac1 Map3k11 Map3k1 other Jnk Map3k Jnk scaffolds ---- Map2k4 adapters ---- Traf2 adapters ---- other upstream c-Jun Mapk9 ---> Jnk cytoplasmic/other targets Mapk9 ---> Jnk nuclear targets Map2k7 --+> Mapk8 Map2k4 --+> Mapk9 effectors/adapters ---- upstream c-Jun effectors/adapters stress conditions adapters Traf2 --+> Map3k5 Map2k7 --+> Mapk9 Map2k4 --+> Mapk8 Jnk scaffolds ---- Mapk8 Map3k11 --+> Map2k4 Map3k4 --+> Map2k4 Map3k1 --+> Map2k4 Map3k4 --+> Map2k7 Jnk scaffolds ---- other Jnk Map3k Mapk8 ---> Jnk cytoplasmic/other targets Jnk Dusp members ---| Mapk8 Jnk Dusp members ---| Mapk9 Map3k11 --+> Map2k7 Mapk8 ---> Jnk nuclear targets Jnk scaffolds Jnk Dusp members Jnk nuclear targets Jnk cytoplasmic/other targets other Jnk Map3k ---> Map2k4 other Jnk Map3k --+> Map2k7 Map3k5 --+> Map2k7 Map3k1 --+> Map2k7
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Genes in Pathway:

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c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:2293876
RGD:2293879
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:2293881
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:2293881
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:2293881
G Dusp19 dual specificity phosphatase 19 JBrowse link 3 67,849,966 67,862,475 RGD:2314491
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:2293881
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:2293875
RGD:2298708
RGD:2298577
RGD:2298561
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:2293875
RGD:2298577
RGD:2298567
RGD:2298561
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:2293879
RGD:2293875
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:2293875
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:2293876
RGD:2298577
RGD:2298567
RGD:2293875
G Map3k12 mitogen activated protein kinase kinase kinase 12 JBrowse link 7 144,102,275 144,120,306 RGD:2293875
G Map3k2 mitogen activated protein kinase kinase kinase 2 JBrowse link 18 24,961,250 25,025,488 RGD:2293879
RGD:2293875
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293879
RGD:2293875
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:2293879
RGD:2293875
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293875
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 6 105,455,461 105,518,974 RGD:2293875
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:2293875
RGD:2298567
RGD:2298561
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:2293875
RGD:2298577
RGD:2298561
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 3 81,295,023 81,304,181 RGD:2293880
RGD:1579811
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293880
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:2293880
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2293875
RGD:2298577
RGD:2298561
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293876
RGD:2293879
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:11534984
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581337
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupJnk Dusp membersdual specificity phosphatases for Jnk Mapks
Gene GroupJnk scaffoldsmembers of the Jip family

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the c-Jun N-terminal kinases MAPK signaling pathway
Pathway TermsGene Symbols
adenosine signaling pathwayCdc42 , Map2k7 , Map3k1 , Map3k4 , Mapk8
amyotrophic lateral sclerosis disease pathwayRac1
angiotensin II signaling pathway via AT2 receptorDusp1
apoptotic cell death pathwayTraf2
Arf family mediated signaling pathwayRac1
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayRac1
Bone morphogenetic proteins signaling pathwayMap3k7
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Dusp19 , Dusp8 , Map2k4 , Map2k7 , Map3k1 , Map3k10 , Map3k11 , Map3k12 , Map3k2 , Map3k3 , Map3k4 , Map3k7 , Map3k9 , Mapk10 , Mapk8 , Mapk8ip1 , Mapk8ip2 , Mapk8ip3 , Mapk9 , Rac1 , Rapgef1 , Spp1 , Traf2
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayCdc42 , Map2k4 , Map3k1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Traf2
chemokine mediated signaling pathwayCdc42 , Rac1
colorectal cancer pathwayMapk10 , Mapk8 , Mapk9 , Rac1
diabetic nephropathy pathwaySpp1
E-cadherin signaling pathwayCdc42 , Rac1
eicosanoid signaling pathwayRac1
endocytosis pathwayCdc42
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9 , Traf2
endothelin signaling pathwayCdc42 , Mapk8 , Rac1
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k4 , Map3k7 , Mapk8 , Rac1
epidermal growth factor/neuregulin signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
Erk5 MAPK signaling pathwayMap3k2 , Map3k3
erythropoietin signaling pathwayMapk8
FasL mediated signaling pathwayMap2k7 , Map3k1 , Mapk10 , Mapk8 , Mapk9
Fc epsilon receptor mediated signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Fc gamma receptor mediated signaling pathwayCdc42 , Rac1
fibroblast growth factor signaling pathwaySpp1
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCdc42 , Map2k4 , Map2k7 , Map3k1 , Map3k2 , Map3k3 , Map3k4 , Mapk10 , Mapk8 , Mapk9
hepatitis C virus infection pathwayMapk10 , Mapk8 , Mapk9 , Traf2
inflammatory response pathwayMapk8
influenza A virus infection pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9
insulin responsive facilitative sugar transporter mediated glucose transport pathwayRac1 , Rapgef1
insulin secretion pathwayCdc42
insulin signaling pathwayMapk10 , Mapk8 , Mapk9 , Rapgef1
interleukin-1 signaling pathwayMap3k3 , Map3k7 , Mapk8
interleukin-2 signaling pathwayMapk8 , Mapk9
interleukin-6 signaling pathwayMap2k4 , Rac1
kidney disease pathwaySpp1
Leishmania infection pathwayMap3k7
measles infection pathwayMap3k7
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Dusp8 , Map2k4 , Map2k7 , Map3k1 , Map3k11 , Map3k12 , Map3k2 , Map3k3 , Map3k4 , Map3k7 , Mapk10 , Mapk8 , Mapk8ip1 , Mapk8ip2 , Mapk8ip3 , Mapk9 , Rac1 , Traf2
mTOR signaling pathwayRac1
Mycobacterium tuberculosis infection pathwayMapk10 , Mapk8 , Mapk9
myocarditis pathwayRac1
N-cadherin signaling pathwayCdc42 , Mapk8 , Rac1
neurotrophic factor signaling pathwayCdc42 , Map2k7 , Map3k1 , Map3k3 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rapgef1
NOD-like receptor signaling pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9
nuclear factor kappa B signaling pathwayMap3k7
p38 MAPK signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Map3k1 , Map3k10 , Map3k11 , Map3k3 , Map3k4 , Map3k7 , Mapk8ip2 , Rac1 , Traf2
p53 signaling pathwayMapk8 , Mapk9
pancreatic cancer pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayRac1
platelet-derived growth factor signaling pathwayMap2k4 , Map2k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Reelin signaling pathwayMap2k7 , Map3k11 , Mapk8
renal cell cancer pathwayCdc42 , Rac1 , Rapgef1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Traf2
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Map2k4 , Mapk8 , Rac1 , Rapgef1
small cell lung cancer pathwayTraf2
sphingosine 1-phosphate signaling pathwayCdc42 , Mapk8 , Rac1
syndecan signaling pathwayMapk8 , Rac1
T cell receptor signaling pathwayCdc42 , Map2k7 , Map3k7 , Mapk9
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Map3k2 , Spp1
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayMap2k4 , Map2k7 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Spp1
Toxoplasma gondii infection pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9
Trail mediated signaling pathwayMap2k4 , Map3k1 , Mapk8 , Traf2
transforming growth factor-beta Smad dependent signaling pathwayMap3k7
Trypanosoma cruzi infection pathwayMap2k4 , Mapk10 , Mapk8 , Mapk9
tumor necrosis factor mediated signaling pathwayMap2k7 , Map3k1 , Map3k3 , Map3k7 , Traf2
type 2 diabetes mellitus pathwayMapk10 , Mapk8 , Mapk9
type II interferon signaling pathwayMap3k1 , Map3k11
ubiquitin/proteasome degradation pathwayMap3k1
vascular endothelial growth factor signaling pathwayCdc42 , Rac1
Wnt signaling pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, non-canonical pathwayCdc42 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1

References Associated with the c-Jun N-terminal kinases MAPK signaling pathway:

Ontology Path Diagram:

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