INTEGRIN MEDIATED SIGNALING PATHWAY (PW:0000286)

View Ontology Report

Description

Integrin mediated signaling involves cell-cell and cell-extracellular matrix (ECM) specific protein interactions. Integrin alpha and beta subunits form the approximately 24 known pairs of receptor heterodimer complexes. In the absence of stimuli the receptors are in a low-affinity ligand binding state - the 'bent' conformation. Structural re-arrangements triggered by agonists give rise to the 'extended', high-affinity ligand binding state. Integrin mediated signaling is bi-directional: binding o

Pathway Diagram:

Ariadne Genomics Inc. Itgb1bp1 ---- Krit1 Tln1 Itga Itga ---- Sharpin Fabp3 ---- Itga Fblim1 ---- filamins cell motility cell differentiation cell proliferation cell survival PIP2 Fblim1 ---| filamins kindlins (Fermt) Ilk Sharpin ---| Itgb Fabp3 Sharpin Fabp3 ---| Itgb Itgb Fblim1 Krit1 Itgb1bp1 ---| Itgb Itgb ---- Itgb1bp1 Itgb1bp1 filamins ---| Itgb filamins ---- Itgb Itgb ---> invasion Ptk2 RTK, others Itgb ---- Tln1 Itgb ---- Tln2 kindlins (Fermt) --+> Itgb Itgb ---- kindlins (Fermt) Itga ---> cell adhesion Itga ---> invasion invasion Ilk ---- Parvb Parva ---- Pxn Nck2 ---- RTK, others Ilk ---- Lims1 Ilk ---- Pxn Ilk ---- Parva Lims1 ---- Nck2 Ptk2 ---- RTK, others Ptk2 ---- Tln1 Ilk ---- Parvg Apbb1ip ---- Tln2 Apbb1ip ---- Tln1 Tln1 --+> Itgb Tln2 cell surface proteins Itgb ---> cell migration Itga ---> cell migration Itga ---> ECM assembly Itgb ---> ECM assembly RTK, others ---> invasion ECM assembly cell migration ECM proteins cell adhesion Itgb ---> cell adhesion Krit1 ---| Itgb1bp1 Tln2 --+> Itgb Pxn Ptk2 ---- Pxn Ilk ---- Lims2 Lims2 Lims1 Ilkap Ilkap ---| Ilk Parvb Parva Parvg Apbb1ip Nck2 Ilk ---- Itgb filamins
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Genes in Pathway:

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integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein JBrowse link 17 90,098,953 90,149,192 RGD:2300340
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:7364738
G Fblim1 filamin binding LIM protein 1 JBrowse link 5 160,122,466 160,158,921 RGD:7349373
G Fermt1 fermitin family member 1 JBrowse link 3 125,566,744 125,607,864 RGD:7349373
G Fermt2 fermitin family member 2 JBrowse link 15 19,807,806 19,876,557 RGD:7349373
G Fermt3 fermitin family member 3 JBrowse link 1 222,254,183 222,272,775 RGD:7349373
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7364738
G Flnb filamin B JBrowse link 15 18,750,152 18,883,019 RGD:7364738
G Flnc filamin C JBrowse link 4 56,710,934 56,738,779 RGD:7364738
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:633110
RGD:2302091
RGD:2300344
G Ilkap ILK associated serine/threonine phosphatase JBrowse link 9 98,514,599 98,536,586 RGD:2300344
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:729264
RGD:5135538
G Itga10 integrin subunit alpha 10 JBrowse link 2 198,772,937 198,792,253 RGD:1358329
RGD:5135538
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:1358329
RGD:5135538
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:1302878
RGD:5135538
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:5135538
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1358329
RGD:5135538
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5135538
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1300196
RGD:5135538
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:1358329
RGD:5135538
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
RGD:5135538
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
RGD:5135538
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:1358329
RGD:5135538
G Itgad integrin subunit alpha D JBrowse link 1 199,595,968 199,623,931 RGD:1358329
RGD:5135538
G Itgae integrin subunit alpha E JBrowse link 10 59,652,324 59,711,885 RGD:633077
RGD:5135538
G Itgal integrin subunit alpha L JBrowse link 1 198,744,053 198,781,745 RGD:1358329
RGD:5135538
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1358329
RGD:5135538
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1358329
RGD:5135538
RGD:1625134
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:5135538
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
RGD:5135538
RGD:1625134
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:7349373
RGD:7364738
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1358329
RGD:5135538
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:633129
RGD:5135538
RGD:1625134
G Itgb4 integrin subunit beta 4 JBrowse link 10 104,524,000 104,560,180 RGD:729025
RGD:5135538
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:724441
RGD:5135538
G Itgb6 integrin subunit beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:1358329
RGD:5135538
G Itgb7 integrin subunit beta 7 JBrowse link 7 143,820,236 143,837,802 RGD:633040
RGD:5135538
G Itgb8 integrin subunit beta 8 JBrowse link 6 147,089,280 147,172,846 RGD:1358329
RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 4 27,438,609 27,473,150 RGD:7349373
RGD:7364738
G Lims1 LIM zinc finger domain containing 1 JBrowse link 20 27,895,981 28,004,767 RGD:2300344
G Lims2 LIM zinc finger domain containing 2 JBrowse link 18 24,707,951 24,746,159 RGD:2300344
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:2300344
G Parva parvin, alpha JBrowse link 1 177,249,302 177,408,160 RGD:2300344
G Parvb parvin, beta JBrowse link 7 125,189,827 125,275,977 RGD:2300344
G Parvg parvin, gamma JBrowse link 7 125,288,081 125,307,587 RGD:2300344
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2300402
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:2300344
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7349373
RGD:7364738
G Tln1 talin 1 JBrowse link 5 59,033,635 59,063,592 RGD:2300340
RGD:7349373
G Tln2 talin 2 JBrowse link 8 73,009,980 73,441,536 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:1302875
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5490966
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1302875
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupfilaminsfilamin activators
Functional ClassItgaintegrin alpha subunit
Functional ClassItgbintegrin beta subunit
Gene Groupkindlins (Fermt)kindlin activators

Pathway Gene Annotations

Disease Annotations Associated with Genes in the integrin mediated signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmItgav
Abortion, SpontaneousItga2 , Itgb4 , Itgb6
Acute Coronary SyndromeItgb3
Acute Lung InjuryItgb2
acute myeloid leukemiaFermt2 , Fermt3 , Itgav , Itgb3
acute promyelocytic leukemiaItgal , Itgam , Itgax , Itgb2
acute retinal necrosis syndromeItga2
adenoid cystic carcinomaItgb4
AlbuminuriaNck2
allergic contact dermatitisItgam
allergic hypersensitivity diseaseItgb2
Alzheimer's diseaseFabp3
amelogenesis imperfecta type 1HItgb6
AneurysmFlna
Angiokeratoma Corporis Diffusum with Arteriovenous FistulasKrit1
angle-closure glaucomaFermt2
ANTERIOR SEGMENT DYSGENESIS 7Pxn
anti-basement membrane glomerulonephritisItga4
aortic aneurysmFlna
Arterial Occlusive DiseasesItgb3
Arterial ThrombosisFlna
arterial tortuosity syndromeFlna
arteriosclerosisItga1 , Itga2 , Itga7 , Itgb3
asthmaItgb3 , Itgb6
atelosteogenesisFlnb
Atelosteogenesis Type 1Flnb
Atelosteogenesis Type 3Flnb
atopic dermatitisSharpin
AtrophyFermt1
autism spectrum disorderItga4 , Itgb3
autistic disorderItga4 , Itgb3 , Itgb6
Autoimmune DiseasesItgb6
autoimmune polyendocrine syndrome type 1Itgb2
autoimmune thrombocytopenic purpuraItgb3
autosomal dominant polycystic kidney diseaseItga8
autosomal recessive limb-girdle muscular dystrophy type 2AFlna
autosomal recessive limb-girdle muscular dystrophy type 2WLims2
bacterial pneumoniaItgb3
Banti's SyndromeItgb3
Behcet's diseaseItga2 , Itgal , Itgb2
blood platelet diseaseFermt3
bone development diseaseFlnb , Itgb1bp1
Boomerang dysplasiaFlnb
Brain NeoplasmsItgb2
Breast NeoplasmsFlna , Itga1 , Ptk2
Bronchial HyperreactivityItgb3
Brugada syndromeItga9
calcinosisItgb1 , Itgb2
Candidiasis, InvasiveItgam
Cardiac ArrhythmiasItga2
Cardiac Valvular Dysplasia, X-LinkedFlna
CardiomegalyItga3
cardiomyopathyFlnc , Ilk , Itga7 , Itgb1
Cardiomyopathy, Hypertrophic, FamilialIlk
Carotid Artery InjuriesItgb3
carotid artery thrombosisItga2b , Itgb3
carotid stenosisItgb3
cavernous hemangiomaKrit1
Cavernous Malformations of CNS and RetinaKrit1
Cell Transformation, NeoplasticPtk2 , Pxn
cerebral cavernous malformationKrit1
Cerebral HemorrhageItga2b , Itgav , Itgb2 , Itgb3
cerebral infarctionItga9
Childhood SchizophreniaItga6
ChloracneItgb2
cholangitisItgb6
Choroidal NeovascularizationItgav
Chronic Lymphocytic Leukemia, B-CellItga4
Chronic PeriodontitisItgb2
chronic ulcer of skinItgb2
cleft palateFlna , Flnb
clubfootFlnb
Cocaine-Related DisordersIlk
colitisItgb2
Colonic NeoplasmsItga7
Colonic PolypsIlk
Colorectal NeoplasmsFlnc , Itgb3
congenital chylothoraxItga9
Congenital Idiopathic Intestinal PseudoobstructionFlna
congenital muscular dystrophyItga7
congenital muscular dystrophy due to integrin alpha-7 deficiencyItga7
congestive heart failureItgb1
Constriction, PathologicItgb3
corneal neovascularizationItgav
coronary artery diseaseItga2
Coronary DiseaseItga2 , Itgb3
coronary restenosisItgb2
coronary stenosisItgav
coronary thrombosisItgb3
Craniofacial AbnormalitiesItgb1bp1
craniosynostosisFlna
dermatitisItgb2 , Sharpin
diabetes mellitusItga2
Diabetic NephropathiesItga2
diabetic retinopathyItga2 , Itga4 , Itgb3
dilated cardiomyopathyFlnc , Ilk , Itgb1
Distal Hereditary Motor Neuropathy, Type VIIALims1
distal muscular dystrophyFlnc
Down syndromeFabp3
Duchenne muscular dystrophyItga7
ductal carcinoma in situPtk2
Ectodermal DysplasiaItgb4
Ehlers-Danlos Syndrome Classic TypeFlna
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsFlna
end stage renal failureItga8 , Itgb3
Endometrial HyperplasiaPtk2
Endometrial NeoplasmsPtk2
endometriosisItga2 , Itgb1 , Itgb8 , Ptk2
EndotoxemiaItga2b , Itgb3
EnterocolitisItgb2
EosinophiliaSharpin
epidermolysis bullosaItgb4
epidermolysis bullosa simplexItgb4
epilepsyFlna , Ilk
ErythemaFermt1
Experimental ArthritisItga4 , Itgb2 , Itgb3
Experimental Autoimmune EncephalomyelitisItga4
Experimental ColitisItga2 , Itga4
Experimental Diabetes MellitusFabp3 , Itga3 , Itgb1 , Itgb3
Experimental Liver CirrhosisApbb1ip , Flna , Ilk , Itga2b , Itgal , Itgb1 , Itgb2 , Itgb3 , Itgb6 , Ptk2
Familial Thoracic Aortic Aneurysm 2Flna
Female InfertilityItga2
FG syndromeFlna
focal segmental glomerulosclerosisItgb3
Frontometaphyseal DysplasiaFlna
galactokinase deficiencyItgb4
genetic diseaseFlna , Flnc , Itga11
Glanzmann's thrombastheniaItga2 , Itga2b , Itgb3
glioblastoma multiformePtk2
GliosisItga1 , Itga2 , Itga4 , Itga5 , Itgb1 , Itgb3 , Itgb4
glomerulonephritisItga3 , Itgam , Itgb1 , Itgb2 , Itgb3
Graft vs Host DiseaseItga2
Graves' diseaseItgb3
Hantavirus InfectionsItgb3
Hearing Loss, ConductiveFlna
Hearing Loss, SuddenItga2
heart valve diseaseItgb2
HemorrhageFermt3 , Itgb3
hemorrhagic diseaseItgb3
hemorrhagic fever with renal syndromeItgb3
Hepatitis C, ChronicItgb6
hepatocellular carcinomaPtk2
Hip FracturesItgb3
Hirschsprung's diseaseItgb1
hydrocephalusItgb1
HyperalgesiaItga1 , Itga2 , Itga3 , Itga5 , Itgb1
hyperglycemiaItgav
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated with Cerebral Capillary MalformationsKrit1
Hyperphosphatasia with Mental Retardation Syndrome 2Tln1
hypertensionFabp3 , Itga9 , Itgav , Ptk2
hypertrophic cardiomyopathyFlnc
hypertrophic cardiomyopathy 26Flnc
Hypertrophy, Left VentricularPtk2
Hypertrophy, Right VentricularPtk2
ileitisItgam
InflammationItgal
inflammatory bowel diseaseItga4 , Itgal , Itgb8
Insulin ResistanceFabp3
intermediate coronary syndromeItga2
Interstitial Lung Disease, Nephrotic Syndrome, and Epidermolysis Bullosa, CongenitalItga3
intestinal pseudo-obstructionFlna
iron deficiency anemiaItga2
ischemiaItgav , Ptk2
junctional epidermolysis bullosaItga6 , Itgb4
junctional epidermolysis bullosa Herlitz typeItga6
junctional epidermolysis bullosa non-Herlitz typeItgb4
junctional epidermolysis bullosa with pyloric atresiaItga6 , Itgb4
juvenile rheumatoid arthritisItga2b , Itgb5
Kidney NeoplasmsItgb2
Kidney Reperfusion InjuryItgb2
Kindler syndromeFermt1
Larsen syndromeFlnb
Larsen SyndromesFlnb
leiomyomaPtk2
leukocyte adhesion deficiencyItgb2
leukocyte adhesion deficiency 1Fermt3 , Itgb2
leukocyte adhesion deficiency 3Fermt3
leukocyte diseaseItgb2
LeukocytosisItga4
Limb IschemiaItgav
liver cirrhosisItgb6
liver diseaseItgb6
long QT syndromeIlk , Krit1
lung diseaseItgb3
lupus nephritisItgam
Lupus Vasculitis, Central Nervous SystemItgam
Malformations of Cortical Development, Group IIFlna
malignant mesotheliomaIlk
Mammary Neoplasms, ExperimentalIlk , Itgb3 , Ptk2
Marfan syndromeFlna
Melanoma, ExperimentalPxn
mesangial proliferative glomerulonephritisItga8
Metabolic SyndromeItgav
mitral valve prolapseFlna
molybdenum cofactor deficiencyItga2
molybdenum cofactor deficiency type AItga2
Mouth NeoplasmsPtk2
Muscle WeaknessFlnc
muscular diseaseFabp3 , Itga7
muscular dystrophyItga7
myelodysplastic syndromeItgb3
myocardial infarctionFabp3 , Itga2 , Itga3 , Itgb1 , Itgb3
Myocardial IschemiaItgav
myofibrillar myopathy 5Flnb , Flnc
Myopathy, Distal, 4Flnc
Nasal PolypsItgal
NecrosisFabp3
Neonatal Alloimmune ThrombocytopeniaItga2b , Itgb3
Neoplasm InvasivenessItga5 , Itgb1 , Ptk2 , Tln1
Neoplasm MetastasisItga6 , Itgb1 , Itgb3 , Ptk2 , Pxn
nephritisItga4 , Itgal , Itgam , Itgb2 , Ptk2
nephrosisItgb2
nephrotic syndromeNck2
NeuralgiaItgam
Niemann-Pick disease type C1Flna
non-arteritic anterior ischemic optic neuropathyItgb3
non-small cell lung carcinomaItgb1 , Itgb3 , Itgb4 , Pxn
obesityFabp3
osteochondrodysplasiaFlna , Flnb
osteogenesis imperfectaItga3
osteopetrosisFermt3
osteoporosisTln1
Oto-Palato-Digital Syndrome Type 1Flna
Oto-Palato-Digital Syndrome, Type 2Flna
Otopalatodigital Spectrum DisorderFlna
Ovarian NeoplasmsFermt3 , Ilk , Itga8 , Ptk2
pancreatic cancerIlk , Itga11 , Itga4 , Itga9
pancreatitisItgb2
periventricular nodular heterotopiaFlna
Periventricular Nodular Heterotopia 4Flna
Phyllodes TumorFlna
placental insufficiencyItga2
Plaque, AtheroscleroticFermt3 , Itgb2 , Itgb3
platelet-type bleeding disorder 16Itga2b , Itgb3
platelet-type bleeding disorder 9Itga2
pleomorphic xanthoastrocytomaFlnc , Itgb8 , Krit1
pneumoniaItga2 , Itga4 , Itgb2 , Itgb3
Posttransfusion PurpuraItgb3
pre-eclampsiaItga4
prostate cancerItgad , Itgb6
Prostatic NeoplasmsIlk , Itgb3 , Ptk2
proteinuriaNck2
psoriasisItgb2
pulmonary emphysemaItgb6
pulmonary hypertensionPtk2
Purpura, ThrombocytopenicItga2b , Itgb3
Pyloric AtresiaItgb4
renal agenesisItga8
Renal Hypodysplasia/Aplasia 1Itga8
Reperfusion InjuryItga2b , Itga5 , Itgb3 , Ptk2
restrictive cardiomyopathyFlnc
Retinal NeovascularizationItgav
retinal vein occlusionItga2
retinitis pigmentosaItga4
retinitis pigmentosa 26Itga4
rheumatoid arthritisItga6 , Ptk2
Salivary Gland NeoplasmsItgb4
schizophreniaItga8
scoliosisFlna
sensorineural hearing lossItga2
SepsisItga4
Smith-Magenis syndromeItga2b , Itga3 , Itgb3 , Itgb4
spinal diseaseFlnb
spondylocarpotarsal synostosis syndromeFlnb
squamous cell carcinomaItga5 , Itgb1 , Ptk2
Stargardt diseaseFlna
Stargardt Disease 1Flna
Stomach NeoplasmsItga5 , Itga8
StrokeItga2 , Itga2b , Itgav , Itgb3
substance-related disorderParva
Sudden Death, CardiacItgb3
systemic lupus erythematosusItgam
telangiectasisFermt1
Terminal Osseous Dysplasia and Pigmentary DefectsFlna
thoracic diseaseIlk
thrombocytopeniaItga2 , Itga2b , Itgb3
thrombocytopenia-absent radius syndromeItga10
thrombosisItga2
Thrombotic MicroangiopathiesItgb3
thyroid gland diseaseItgb5
transient cerebral ischemiaIlk , Itgb3
Transplant RejectionItga4
tuberous sclerosisFlna
type 1 diabetes mellitusItga2 , Itga4
type 2 diabetes mellitusFabp3 , Itga2
UlcerItgb3
uremiaPtk2
urinary bladder cancerFermt2
Uterine Cervical NeoplasmsPtk2
Venous ThrombosisItga2 , Itgb3
venous tributary occlusion of retinaItga2
vesiculobullous skin diseaseFermt1
visual epilepsyFlna
Vogt-Koyanagi-Harada diseaseItgb2
von Willebrand's disease 1Itga2 , Itga2b
von Willebrand's disease 2Itga2 , Itga2b
Wolff-Parkinson-White syndromeFlna , Flnc
Pathway Annotations Associated with Genes in the integrin mediated signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItga2b , Itgb3
altered integrin mediated signaling pathwayIlk , Itga1 , Itga11 , Itga4 , Itga5 , Itga7 , Itga8 , Itga9 , Itgb1
altered Reelin signaling pathwayItga3 , Itgb1
arrhythmogenic right ventricular cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
calcium signaling pathway via the calcium-sensing receptorFlna
cell-extracellular matrix signaling pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
chemokine mediated signaling pathwayPtk2 , Pxn
dilated cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
E-cadherin signaling pathwayItgae , Itgb7
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaFabp3 , Ilk
endometrial cancer pathwayIlk
Entamoebiasis pathwayItgam , Itgb2 , Ptk2
ephrin - ephrin receptor bidirectional signaling axisItga2b , Itgb3 , Nck2 , Pxn
epidermal growth factor/neuregulin signaling pathwayNck2 , Ptk2 , Tln1
eptifibatide pharmacodynamics pathwayItga2b , Itgb3
glomerulonephritis pathwayItga8 , Itgb1
hypertrophic cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
hypoxia inducible factor pathwayItgb2
insulin signaling pathwayNck2
insulin-like growth factor signaling pathwayNck2 , Pxn
integrin mediated signaling pathwayApbb1ip , Fabp3 , Fblim1 , Fermt1 , Fermt2 , Fermt3 , Flna , Flnb , Flnc , Ilk , Ilkap , Itga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga3 , Itga4 , Itga5 , Itga6 , Itga7 , Itga8 , Itga9 , Itgad , Itgae , Itgal , Itgam , Itgav , Itgax , Itgb1 , Itgb1bp1 , Itgb2 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8 , Krit1 , Lims1 , Lims2 , Nck2 , Parva , Parvb , Parvg , Ptk2 , Pxn , Sharpin , Tln1 , Tln2
interleukin-4 signaling pathwayItgb3
Leishmaniasis pathwayItga4 , Itgam , Itgb1 , Itgb2
long term potentiationPtk2
malaria pathwayItgal , Itgb2
mitogen activated protein kinase signaling pathwayFlna , Flnb , Flnc
mTOR signaling pathwayPxn
myocardial infarction pathwayItga1 , Itga5
myocarditis pathwayItgal , Itgb2
nuclear factor kappa B signaling pathwaySharpin
pancreatic cancer pathwayIlk , Itga11 , Itga4 , Itga9
phagocytosis pathwayItga2 , Itga5 , Itgam , Itgb1 , Itgb2 , Itgb3 , Itgb5
platelet aggregation pathwayItgb3
platelet-derived growth factor signaling pathwayItgav , Itgb3 , Nck2
Reelin signaling pathwayItga3 , Itgb1 , Nck2
rheumatoid arthritis pathwayItgal , Itgb2
Rho/Rac/Cdc42 mediated signaling pathwayFlna
small cell lung carcinoma pathwayItga2 , Itga2b , Itga6 , Itgb1 , Ptk2
sphingosine 1-phosphate signaling pathwayItgav , Itgb3
Staphylococcus aureus infection pathwayItgal , Itgam , Itgb2
syndecan signaling pathwayItga2 , Itga5 , Itgb1
T cell receptor signaling pathwayNck2
tirofiban pharmacodynamics pathwayItga2b , Itgb3
toxoplasmosis pathwayItga6 , Itgb1
tuberculosis pathwayItgam , Itgax , Itgb2
tumor necrosis factor mediated signaling pathwaySharpin
vascular endothelial growth factor signaling pathwayItgav , Itgb3 , Nck2 , Ptk2 , Pxn
Wnt signaling, non-canonical pathwayFlna
Phenotype Annotations Associated with Genes in the integrin mediated signaling pathway

References Associated with the integrin mediated signaling pathway:

Ontology Path Diagram:

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