ANGIOTENSIN II SIGNALING PATHWAY (PW:0000244)

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Description

Agiotensin II (AgtII), the product of Ace action in the renin-angiotensin system, is probably the most potent of the biologically active peptides the pathway generates. The system, originally viewed as solely endocrine, is now regarded as an endocrine, paracrine and autocrine one, producing an array of diverse and many times opposing actions via both the 'classical' or circulatory and the local or 'tissue' routes. Overall AgtII elicits distinct responses through signaling via receptor type 1 and

Pathway Diagram:

Ariadne Genomics Inc. Agtr1b ---> Agtr1, G protein/ligand independent signaling protein kinase C (PKC) signaling pathway AgtII renin-angiotensin system signaling pathway Agtr1a ---> Agtr1, G protein/ligand independent signaling fluid homeostasis hormone release Agtr2 ---> Agtr2, G protein/ligand independent signaling vasoconstriction antiproliferation vasodilation Agtr2, G protein/ligand independent signaling angiotensin II signaling pathway via AT2 receptor angiotensin II signaling pathway via AT1 receptor AgtII ---> hormone release AgtII ---> fluid homeostasis AgtII ---> antiproliferation AgtII ---> vasoconstriction AgtII ---- Agtr2 AgtII ---- Agtr1b Agtr2 Agtr1a Agtr1b Agt Agt ---> AgtII Agtr1, G protein/ligand independent signaling G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family AgtII ---- Agtr1a AgtII ---> vasodilation
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Genes in Pathway:

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angiotensin II signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1581742
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1579760
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:629553
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1566502
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1582323
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:1581745
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1600094
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580992
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1581775
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:12910844
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1642674
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1581847
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1581825
RGD:5133683
RGD:2316188
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1581825
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:2314353
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 JBrowse link 1 166,459,062 166,525,200 RGD:2316188
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:5133417
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5133417
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1581847
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1581847
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:5133417
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5133417
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:5133417
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:5133417
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5133683
RGD:6478796
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:5133418
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:6478796
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
RGD:7401256
RGD:1582435
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
RGD:7401256
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin cascade pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAce , Agt , Agtr1a , Ccl2
Abortion, SpontaneousAgtr1a , Jak2
acquired immunodeficiency syndromeCcl2
Acute Anterior UveitisCcl2
acute kidney failureAce
Acute Liver FailureCcl2
Acute Lung InjuryCcl2
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak2
acute myeloid leukemiaCcl2 , Jak2
Acute Necrotizing PancreatitisCcl2
adenocarcinomaAce
adult respiratory distress syndromeAce , Ccl2
age related macular degenerationCcl2
aggressive periodontitisCcl2
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt
alcoholic cardiomyopathyAce , Agt
alcoholic hepatitisAgt
alcoholic liver cirrhosisJak2
AlkalosisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a
allergic conjunctivitisCcl2
allergic hypersensitivity diseaseAce , Agt , Ccl2
allergic rhinitisAce
Alzheimer's diseaseAce , Agt , Agtr1a , Jak2
Alzheimer's disease 1Ace
AnaphylaxisAgt , Cma1
anemiaAce , Agt , Ccl2 , Jak2
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
ankylosing spondylitisAce , Jak2
anterior uveitisCcl2
anti-basement membrane glomerulonephritisAgt , Agtr1a , Ccl2
anuriaAgt
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAce , Agt
arteriosclerosisCcl2
Arteriovenous FistulaAce
aspiration pneumoniaAce
asthmaAce , Agtr1a , Agtr2 , Ccl2 , Cma1
atherosclerosisAgt , Ccl2
atopic dermatitisCma1
atrial fibrillationAce , Agt , Agtr1a
autistic disorderAce , Ccl2
autoimmune hepatitisCcl2
autosomal recessive Parkinson's disease 14Pla2g6
autosomal recessive polycystic kidney diseaseAce
BacteremiaCcl2
bacterial pneumoniaCcl2
Behcet's diseaseAce , Ccl2
berylliosisAce
bipolar disorderAce , Agt , Ccl2
BradycardiaAgt
Brain InjuriesCcl2 , Jak2
brain ischemiaAce , Ccl2
Breast NeoplasmsAce , Agt , Agtr1a , Pdpk1
Bronchial HyperreactivityCcl2
bronchiolitis obliteransAce , Ccl2
Budd-Chiari syndromeJak2
calcinosisCcl2 , Jak2
Cardiac ArrhythmiasAce , Agt , Agtr1a
CardiomegalyAce , Agt , Agtr1a , Agtr1b , Cma1 , Prkcz
cardiomyopathyAgt , Ccl2 , Olr1
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAce , Agt , Ccl2
carotid artery diseaseAce , Agt , Agtr1a , Ccl2
Carotid Artery InjuriesAgtr1a , Ccl2
Carrington SyndromeCcl2
CatalepsyAgt
cerebral amyloid angiopathyOlr1
Cerebral HemorrhageAce
cerebral infarctionAce
cerebrovascular diseaseAgt , Agtr1a
Chagas diseaseCcl2
Chemical and Drug Induced Liver InjuryCcl2
Chemotherapy-Induced Febrile NeutropeniaAce
cholestasisAgt
Choroidal NeovascularizationCcl2
Chronic Intermittent HypoxiaAce , Agt
chronic kidney diseaseAgtr1a , Agtr2
chronic myeloid leukemiaAce , Agt , Jak2
chronic obstructive pulmonary diseaseAce , Ccl2 , Cma1
Chronic PeriodontitisCcl2
Chronic Relapsing Experimental Autoimmune EncephalomyelitisCcl2
Chronic Tubulointerstitial NephropathyCcl2
cognitive disorderAgt
colitisCcl2
Colonic NeoplasmsCcl2
congenital diaphragmatic herniaAce , Agtr2
congenital heart diseaseCma1
Congenital Hepatic FibrosisAce
congestive heart failureAce , Agt , Agtr1a , Agtr2 , Ccl2 , Olr1 , Pdpk1
contact dermatitisCcl2
ContusionsCcl2
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAce , Agt , Agtr1a , Ccl2 , Olr1
Coronary Artery Disease, Development of, in HIVCcl2
Coronary DiseaseAce , Agtr1a
coronary restenosisAce
Coronavirus InfectionsAce
CoughAce
crescentic glomerulonephritisCcl2
Crohn's diseaseAgt , Ccl2 , Jak2
cryptococcosisCcl2
cutaneous leishmaniasisCcl2
cystic fibrosisCcl2
Delayed HypersensitivityCcl2
Diabetes Mellitus, Experimental Ace , Agt , Agtr2 , Ccl2 , Cma1
diabetic angiopathyCcl2
Diabetic CardiomyopathiesAce , Agtr2
Diabetic NephropathiesAce , Agt , Agtr1a , Agtr2 , Ccl2 , Jak2
diabetic retinopathyAce , Agt , Agtr1a , Ccl2
Diaphragmatic HerniaAgt , Agtr1a , Agtr1b
diffuse large B-cell lymphomaPdpk1
diffuse sclerodermaAgt
dilated cardiomyopathyAce , Agt , Agtr1a , Agtr2
Dissecting AneurysmAgt
drug allergyAce
Drug OverdoseAgt
Duchenne muscular dystrophyCcl2 , Pla2g6
Ductal CarcinomaAgtr1a
dystonia 12Pla2g6
end stage renal failureAce , Agt , Agtr2 , Ccl2 , Olr1
Endometrial NeoplasmsCcl2
endometriosisCcl2
endomyocardial fibrosisAce , Agt , Ccl2
EndotoxemiaAce , Agtr2 , Ccl2
Endotoxin-Induced UveitisCcl2
essential hypertensionAgt , Agtr1a
essential thrombocythemiaJak2
Experimental ArthritisAce , Ccl2 , Jak2
Experimental Autoimmune EncephalomyelitisCcl2 , Jak2
Experimental Autoimmune MyocarditisCcl2
Experimental Autoimmune OrchitisCcl2
Experimental Autoimmune UveitisCcl2
Experimental Autoimmune UveoretinitisCcl2
Experimental Liver CirrhosisAgt , Agtr1a , Ccl2 , Jak2
Experimental Liver NeoplasmsJak2
extrinsic allergic alveolitisAce
Eye NeoplasmsCcl2
Fabry diseaseAce , Agt
Familial Cerebral Cavernous MalformationAce
familial erythrocytosis 1Jak2
familial erythrocytosis 2Jak2
familial hyperlipidemiaCcl2
fatty liver diseaseCcl2 , Jak2
Febrile NeutropeniaCcl2
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Agtr2
FibrosisAgt , Agtr1a , Agtr2
focal segmental glomerulosclerosisAgt , Agtr1a , Agtr2
focal segmental glomerulosclerosis 1Ace
fungal infectious diseaseCcl2
Gallbladder NeoplasmsAce
gastric ulcerAgt
gastritisCcl2
Gaucher's diseaseAce
genetic diseasePla2g6
Genetic Predisposition to DiseaseAce
Geographic AtrophyCcl2
gestational diabetesCcl2
gliosarcomaCcl2
glomerulonephritisAce , Agt , Agtr2 , Ccl2
glomerulosclerosisAce , Agtr1a , Agtr2
glucose intoleranceAgt , Agtr1a , Jak2
glycogen storage disease VAce
GranulomaCma1
Granuloma, Respiratory TractCcl2
Granulomatous Interstitial NephritisCcl2
Granulomatous VasculitisCcl2
Graves OphthalmopathyCcl2
Growth DisordersJak2
Guillain-Barre syndromeCcl2
Hearing Loss, Noise-InducedCcl2
heart diseaseAgt , Jak2
heart valve diseaseCcl2 , Jak2
hemarthrosisCcl2
hemolytic-uremic syndromeCcl2
HemorrhageAgt
Henoch-Schoenlein purpuraAce , Agt , Ccl2
hepatocellular carcinomaAce
herpes simplexCcl2
herpes simplex virus keratitisCcl2
human immunodeficiency virus infectious diseaseCcl2
Human InfluenzaCcl2
Huntington's diseaseAgtr1a
hydronephrosisAgt
HyperalgesiaAgt , Ccl2 , Jak2 , Prkcz
HyperemiaAgt
hyperglycemiaPrkcz
hyperhomocysteinemiaCcl2
hyperinsulinismAgt , Agtr1a , Ccl2
HyperoxaluriaCcl2
HyperoxiaAce
hypertensionAce , Agt , Agtr1a , Agtr1b , Agtr2 , Ccl2 , Cma1 , Olr1
Hypertension, Pregnancy-InducedAce , Agt
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce
hypertrophic cardiomyopathyAce , Agt , Cma1
HypertrophyAgt
hyperuricemiaJak2
hypoglycemiaAgtr2
hypokalemiaAgt
HypotensionAce , Agt
HypoxiaCcl2
Hypoxia-Ischemia, BrainAgtr2 , Ccl2
IgA glomerulonephritisAce , Agt , Agtr1a , Agtr2 , Ccl2
impotenceAgt
in situ carcinomaAce
InflammationAgt , Agtr1a , Agtr2 , Ccl2 , Jak2
inflammatory bowel diseaseAgt
influenzaCcl2
Insulin ResistanceAce , Agtr2 , Ccl2 , Prkcz
intellectual disabilityAgtr2
intermediate coronary syndromeAce , Agt , Agtr1a
interstitial lung diseaseCcl2 , Cma1
interstitial nephritisCcl2
Intestinal Reperfusion InjuryAce , Agt , Ccl2 , Jak2
intracranial aneurysmAce , Ccl2
intracranial vasospasmCcl2
invasive aspergillosisCcl2
invasive lobular carcinomaAgtr1a , Agtr2
Invasive Pulmonary AspergillosisCcl2
ischemiaCcl2
juvenile rheumatoid arthritisOlr1
Karak SyndromePla2g6
kidney diseaseAce , Agt , Agtr1a , Ccl2
kidney failureAce , Agt
Kidney Reperfusion InjuryAce , Ccl2
Kuhnt-Junius degenerationCcl2
Left Ventricular HypertrophyAce , Agt , Agtr1a , Agtr2 , Cma1 , Prkcz
leukemiaAce , Jak2 , Prkcz
leukostasisAce
Limb IschemiaAgtr1a
limited sclerodermaCcl2 , Jak2
lipodystrophyCcl2
liver cirrhosisAgt , Ccl2
liver diseaseCcl2
Liver InjuryJak2
Liver Reperfusion InjuryCcl2 , Jak2
Lower Extremity Deep Vein ThrombosisCcl2
lung diseaseAce , Agtr1a , Ccl2
Lung InjuryCcl2
Lung NeoplasmsAce
lupus nephritisCcl2
Lyme NeuroborreliosisCcl2
Lymphatic MetastasisPdpk1
macular degenerationCcl2
macular retinal edemaCcl2
male infertilityAce
malignant hypertensionAgt
Mammary Neoplasms, ExperimentalAgt , Agtr1a , Agtr2
meconium aspiration syndromeAgt , Agtr2
melanomaCcl2
membranoproliferative glomerulonephritisCcl2
Memory DisordersAce
Meningococcal InfectionsAce
Mental Retardation, X-LinkedAgtr2
Mental Retardation, X-Linked 88Agtr2
mesenteric vascular occlusionJak2
Metabolic SyndromeAgt , Agtr1a , Ccl2 , Pla2g6
Microvascular Complications of Diabetes, Susceptibility to, 2Ace
Microvascular Complications of Diabetes, Susceptibility to, 3Ace
middle cerebral artery infarctionAce , Agt , Ccl2
mitral valve prolapseAce , Agt
Mouth NeoplasmsCcl2
Multiple AbnormalitiesPla2g6
multiple myelomaAce , Ccl2
Multiple Organ FailureCcl2
multiple sclerosisAgt , Ccl2
Mycobacterium Tuberculosis, Susceptibility To Infection ByCcl2
myelofibrosisJak2
myeloid neoplasmJak2
myeloproliferative neoplasmJak2
myocardial infarctionAce , Agt , Agtr1a , Ccl2 , Jak2 , Olr1
Myocardial IschemiaAgt , Ccl2 , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Ccl2 , Jak2 , Olr1
myocarditisAce , Ccl2 , Cma1
Nasal PolypsCcl2
NecrosisAgt
NeointimaAgt
Neoplasm InvasivenessCcl2
Neoplasm MetastasisAce , Agtr1a , Agtr2 , Ccl2
nephritisAce , Agtr1a , Ccl2
nephrosisAce , Agt
Nephrosis, Puromycin AminonucleosideAce , Agt
nephrotic syndromeAce , Jak2
neural tube defectCcl2
neuroaxonal dystrophyPla2g6
neurodegeneration with brain iron accumulationPla2g6
neurodegeneration with brain iron accumulation 2APla2g6
neurodegeneration with brain iron accumulation 2BPla2g6
neurodegenerative diseasePla2g6
NevusPla2g6
Niemann-Pick disease type C1Jak2
non-arteritic anterior ischemic optic neuropathyAce
non-small cell lung carcinomaPdpk1
nonalcoholic fatty liver diseaseAce , Jak2
obesityAce , Agt , Agtr2 , Ccl2 , Jak2
Obstetric Labor, PrematureCcl2
obstructive jaundiceCcl2
obstructive sleep apneaAce , Ccl2
ocular hypotensionAce
oral squamous cell carcinomaCcl2
orchitisCcl2
osteoporosisAce
otosclerosisAgt
ovarian cystAgtr2
Oxygen-Induced RetinopathyCcl2
PainAce , Ccl2
Painful NeuropathyCcl2
pancreatic cancerAce , Agtr2
pancreatic ductal carcinomaAce , Agtr1a
pancreatitisCcl2
Parkinson's diseaseAce , Agtr1a , Pla2g6
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
Perennial Allergic RhinitisCcl2
Peri-ImplantitisCcl2
periapical periodontitisCcl2
Periodontal CystCcl2
periodontitisCcl2
Peripheral Nerve InjuriesCcl2
Peritoneal FibrosisAce
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
pleural diseaseCcl2
pleurisyPla2g6
pneumocystosisCcl2
pneumoniaAce , Agt , Ccl2
polycystic kidney diseaseAgt
polycythemiaAce , Jak2
polycythemia veraJak2
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
pre-eclampsiaAce , Agt
pre-malignant neoplasmAce
prediabetes syndromeAgt
Pregnancy ComplicationsJak2
Premature Infant DiseasesAce
Prenatal Exposure Delayed EffectsAgtr1b
primary biliary cirrhosisAce , Agt , Jak2
proliferative diabetic retinopathyCcl2
prostate adenocarcinomaPdpk1
prostate cancerPdpk1
Prostatic NeoplasmsAce , Jak2 , Prkcz
proteinuriaAce , Agt , Agtr1a
Pulmonary ContusionCcl2
pulmonary edemaAgt , Ccl2
pulmonary embolismCcl2
pulmonary emphysemaCcl2
pulmonary fibrosisAce , Agt , Agtr1a , Agtr2 , Ccl2 , Cma1
pulmonary hypertensionAce , Agt , Agtr1a , Ccl2
pulmonary tuberculosisCcl2
pyelonephritisAce
Radiation Injuries, ExperimentalAgtr1a , Agtr2
Radiation NephropathyAce
renal cell carcinomaAgtr1a , Agtr2
renal fibrosisAce
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a
renovascular hypertensionAce , Agtr1a , Agtr1b , Agtr2
Reperfusion InjuryAce , Agt , Agtr2 , Ccl2 , Jak2
respiratory system diseaseAce
Retina Reperfusion InjuryCcl2
retinal degenerationCcl2
retinal detachmentCcl2 , Jak2
retinal vasculitisAgt
retinitisCcl2
retinopathy of prematurityAgt
rheumatoid arthritisCcl2 , Jak2
Right Ventricular HypertrophyAce
sarcoidosisAce , Agtr1a , Cma1
sarcomaCcl2
schizophreniaCcl2
sciatic neuropathyAgt , Ccl2
scrapieJak2
Seasonal Allergic RhinitisCma1
sensorineural hearing lossAce
SepsisCcl2 , Jak2
Sepsis-Associated EncephalopathyJak2
severe acute respiratory syndromeAce
sick sinus syndromeAgt
silicosisCcl2
skin melanomaAgt
Smith-Magenis syndromeAce , Ccl2
spina bifidaCcl2
Spinal Cord CompressionCcl2
Spinal Cord InjuriesJak2 , Pla2g6
squamous cell carcinomaCcl2
Staphylococcal InfectionsAce
status epilepticusCcl2
Stomach NeoplasmsAce , Agtr2
StrokeAce , Agt , Agtr2 , Ccl2 , Jak2
substance-induced psychosisAce
Sudden DeathAce , Agt
systemic lupus erythematosusAce , Agtr2 , Ccl2 , Jak2
systemic sclerodermaAce , Agt , Ccl2
temporal arteritisCcl2
temporal lobe epilepsyAgt
Thrombocythemia 3Jak2
thrombocytopeniaCcl2
thrombocytosisJak2
ThromboembolismJak2
thrombosisAgt
thyroid gland diseaseCcl2
Thyroid NeoplasmsCcl2
transient cerebral ischemiaAgt , Ccl2 , Jak2
Transplant RejectionCcl2
type 1 diabetes mellitusAce , Ccl2
type 2 diabetes mellitusAce , Agt , Agtr2 , Ccl2 , Prkcz
ulcerative colitisJak2
ureteral obstructionAce , Agt , Ccl2
Urogenital AbnormalitiesAgtr2
Uterine Cervical NeoplasmsJak2
uveitisAce , Ccl2
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr1a , Agtr2
Vasculitis of the SkinCcl2
Venous ThromboembolismAce
Venous ThrombosisCcl2 , Jak2
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Agtr1a
vesicoureteral refluxAgtr1a , Agtr2
viral pneumoniaAce , Ccl2
visual epilepsyAgt
Wallerian DegenerationPla2g6
Weight GainAce
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adenosine signaling pathwayPdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2 , Pdpk1
alpha-linoleic acid metabolic pathwayPla2g6
altered Jak-Stat signaling pathwayJak2
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Ccl2 , Cma1 , Jak2 , Olr1 , Pdpk1 , Pla2g6 , Prkcz
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b , Jak2
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
arachidonic acid metabolic pathwayPla2g6
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a
captopril pharmacodynamics pathwayAce , Agt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
ceramide signaling pathwayPrkcz
Chagas disease pathwayAce
chemokine mediated signaling pathwayCcl2 , Jak2 , Prkcz
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
eicosanoid signaling pathwayPrkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaOlr1 , Pdpk1
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a
enalapril pharmacokinetics pathwayAce
endocytosis pathwayPrkcz
endometrial cancer pathwayPdpk1
endothelin signaling pathwayJak2
epidermal growth factor/neuregulin signaling pathwayPrkcz
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
ether lipid metabolic pathwayPla2g6
ether lipid metabolic pathwayPla2g6
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayPla2g6
Fc gamma receptor mediated signaling pathwayPla2g6
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a , Agtr1b
glutamate signaling pathwayPla2g6
glycerophospholipid metabolic pathwayPla2g6
gonadotropin-releasing hormone signaling pathwayPla2g6
granulocyte-macrophage colony-stimulating factor signaling pathwayCcl2 , Jak2
growth hormone signaling pathwayJak2
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
influenza A pathwayJak2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz
insulin signaling pathwayPdpk1 , Prkcz
insulin-like growth factor signaling pathwayPdpk1 , Prkcz
interleukin-1 signaling pathwayPrkcz
interleukin-12 signaling pathwayJak2
interleukin-23 signaling pathwayCcl2 , Jak2
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2
kallikrein-kinin cascade pathwayAce
Leishmaniasis pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
linoleic acid metabolic pathwayPla2g6
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a
long term depressionPla2g6
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a
measles pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayPla2g6
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a
moexipril pharmacokinetics pathwayAce
mTOR signaling pathwayPdpk1
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
non-small cell lung carcinoma pathwayPdpk1
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a
phagocytosis pathwayOlr1
phenytoin pharmacodynamics pathwayAgtr1a
phosphatidylinositol 3-kinase class I signaling pathwayPdpk1
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayJak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
prostate cancer pathwayPdpk1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkcz
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Agtr1b , Agtr2 , Cma1
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayJak2
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
toxoplasmosis pathwayJak2 , Pla2g6
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a
trandolapril pharmacokinetics pathwayAce
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
tuberculosis pathwayJak2
tumor necrosis factor mediated signaling pathwayPrkcz
type 2 diabetes mellitus pathwayPrkcz
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a
vascular endothelial growth factor signaling pathwayCcl2 , Pdpk1 , Pla2g6 , Prkcz
verapamil pharmacodynamics pathwayAgtr1a
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway

References Associated with the angiotensin II signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: