VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY (PW:0000243)

View Ontology Report

Description

Vascular endothelial growth factor signaling pathway (VEGF) regulates vasculogenesis, angiogenesis, lymphanogiogenesis and vascular permeability as well as the migration of monocytes and macrophages and the recruitment of haematopoietic cells. Several VEGFs (five in mammals) bind to one or more of the three VEGF receptor tyrosine kinases (RTK) to accomplish these important vascular functions. By far, the best characterized receptor and the focus of this synopsis and diagram is Kdr also known as

Pathway Diagram:

Ariadne Genomics Inc. Flt4 --+> vasculogenesis/lymphangiogensis Prkcb --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Prkca --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Prkcz --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway DAG --+> Prkca DAG --+> Prkcb DAG --+> Prkcz the extracellular signal-regulated Raf/Mek/Erk signaling pathway --+> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway --+> cell survival Plcg1 --+> PIP3 SHB --+> phosphatidylinositol 3-kinase-Akt signaling pathway Kdr --+> vasculogenesis/angiogensis Kdr p38 MAPK signaling pathway --+> actin remodeling Nck1 --+> p38 MAPK signaling pathway Flt1 --+> vascular permeability/monocyte migration/haematopoiesis Nrp2 Nrp1 vascular permeability/monocyte migration/haematopoiesis Ptk2 Plcg1 Fyn Nck1 Sh2d2a Prkca Prkcb Prkcz SHB Flt4 Figf Vegfc Flt1 Vegfa Pgf DAG Fyn ---- Nck1 Kdr ---- Sh2d2a Kdr --+> Plcg1 Flt1 ---- Vegfb Flt1 ---- Pgf Flt1 ---- Vegfa Flt4 ---- Vegfc Figf ---- Flt4 Kdr ---- Nck1 Kdr ---- SHB Kdr ---- Vegfa IP3 Nrp1 ---- Vegfa Nrp2 ---- Vegfa Ptk2 ---- SHB p38 MAPK signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway cell survival Vegfb cell proliferation PIP3 the extracellular signal-regulated Raf/Mek/Erk signaling pathway actin remodeling vasculogenesis/angiogensis vasculogenesis/lymphangiogensis
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap1 A-kinase anchoring protein 1 JBrowse link 10 76,151,013 76,183,987 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6484113
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 JBrowse link 12 39,253,409 39,302,601 RGD:6484113
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1580560
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6484113
RGD:6907045
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6484113
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:6484113
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:1334466
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:727754
RGD:1334466
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1334466
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:6484113
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1626621
RGD:6484113
RGD:2298727
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:727326
RGD:6484113
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:2298729
RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:6484113
G Hif1a hypoxia inducible factor 1 alpha subunit JBrowse link 6 96,810,868 96,856,303 RGD:625724
RGD:2301848
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6484113
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6907045
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:6484113
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:6484113
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6484113
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:729081
RGD:6907045
RGD:6484113
RGD:2301848
RGD:2298729
RGD:2298727
RGD:2292019
RGD:1626621
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6484113
RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:6484113
RGD:6907045
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:6907045
G Myof myoferlin JBrowse link 1 256,585,410 256,734,727 RGD:6484113
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:2298729
RGD:6484113
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:6484113
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:6907045
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6907045
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:6907045
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6907045
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6484113
RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1334463
RGD:6484113
RGD:2298727
RGD:1581611
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6484113
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:633657
RGD:2298727
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:6907045
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:6907045
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:6907045
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6907045
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:6907045
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6907045
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:2298729
RGD:6907045
RGD:6484113
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6907045
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6907045
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6484113
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6484113
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:2298729
RGD:6907045
RGD:6484113
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:2298729
RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:2298730
RGD:6484113
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:2298729
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6907045
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2298729
RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:6484113
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6484113
RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
RGD:6907045
G RGD1560225 similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 RGD:6907045
G RGD1564956 similar to calcium binding protein P22 JBrowse link 5 70,747,534 70,749,967 RGD:6907045
G RGD1565588 similar to calcium binding protein P22 JBrowse link 4 6,477,461 6,479,158 RGD:6907045
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6484113
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:2298729
RGD:6907045
RGD:6484113
G Shb SH2 domain containing adaptor protein B JBrowse link 5 60,970,650 61,077,881 RGD:6484113
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6907045
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:6907045
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
RGD:6907045
G Vcl vinculin JBrowse link 15 3,455,211 3,544,738 RGD:6484113
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:625593
RGD:6907045
RGD:2301956
RGD:2301848
RGD:2298727
RGD:2292019
RGD:1626621
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:1334463
RGD:2298727
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:727326
RGD:6484113
RGD:2298727
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:727326
RGD:6484113
RGD:2298727
G Vtn vitronectin JBrowse link 10 65,767,960 65,771,040 RGD:6484113
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019

Pathway Gene Annotations

Disease Annotations Associated with Genes in the vascular endothelial growth factor signaling pathway
Disease TermsGene Symbols
aberrant crypt fociCtnnb1 , Mapk1 , Mapk3
Abnormalities, Drug-InducedRhoa
Abnormalities, MultipleCav1 , Cdc42 , Ctnnb1 , Kras , Mapk1 , Pik3r2 , Pla2g6
Abortion, SpontaneousPgf
Abruptio PlacentaeNos3
acoustic neuromaCav1 , Vegfa
acute anterior uveitisCcl2
Acute Chest SyndromeNos3 , Vegfa
Acute Coronary SyndromeItgb3 , Vcl
Acute Kidney InjuryBad , Egln1 , Egln3 , Hif1a , Nos3 , Ptgs2 , Vegfa
Acute Lung InjuryCav1 , Ccl2 , Flt1 , Kdr , Pla2g2a , Prkaa1 , Ptgs2 , Vegfa
Acute-Phase ReactionHif1a
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCtnnb1 , Kdr , Kras , Nos3 , Pik3ca , Ptgs2 , Ptpn11 , Sphk1 , Vegfa
adenocarcinoma of esophagusPik3ca , Ptgs2
ADENOCARCINOMA OF STOMACHAkt1 , Braf , Ctnnb1 , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Ptpn11 , Raf1 , Rhoa
Adenocarcinoma, Bronchiolo-AlveolarKras
Adenocarcinoma, ColonMapk1 , Mapk3 , Pik3r3 , Rac1
Adenocarcinoma, ColorectalMapk1 , Mapk3 , Raf1
Adenocarcinoma, FollicularKras
adenoid cystic carcinomaHras , Kras , Map2k2 , Pik3ca
AdenomaCtnnb1 , Kras
Adenoma, ColorectalRaf1
Adenoma, Liver CellCtnnb1 , Hras , Kras
Adenomatous Polyposis ColiAkt1 , Ptgs2
adrenal carcinomaBraf , Ctnnb1 , Nras , Pik3ca
adrenal gland neoplasmsCdc42 , Ctnnb1 , Prkaca , Ptgs2
Adrenal InsufficiencyPla2g2a
adrenocortical adenomaPrkaca
Adrenocortical CarcinomaBraf , Ctnnb1 , Nras , Pik3ca
adult respiratory distress syndromeCcl2 , Pla2g2a , Pla2g4a
adult-onset Still's diseaseVegfa
Agammaglobulinemia 7, Autosomal RecessivePik3r1
aggressive periodontitisCcl2
albuminuriaNck1 , Nck2 , Ptgs2
Alcohol Withdrawal DeliriumPtgs2
allergic conjunctivitisCcl2 , Pla2g2a
allergic hypersensitivity diseaseCcl2 , Map2k6
Alport Syndrome, Recessive TypeHras
Alveolitis, Extrinsic AllergicVegfa
Alzheimer's DiseaseAkt1 , Bad , Calm1 , Cdc42 , Ctnnb1 , Fyn , Hif1a , Hras , Hsp90aa1 , Hspb1 , Mapk14 , Nos3 , Pik3r1 , Plcg2 , Ptgs2 , Vegfa
AmeloblastomaBraf
Amnesia, RetrogradePtgs2
Amphetamine-Related DisordersAkt1
amyotrophic lateral sclerosisAkt1 , Bad , Casp9 , Kdr , Mapk14 , Pgf , Pla2g4a , Ptgs2 , Vegfa
AnaphylaxisPtgs2
AnaplasiaHif1a
AnemiaCcl2 , Kras
Angina, UnstableAkt1
angle-closure glaucomaNos3
ankylosing spondylitisPgf
ANTERIOR SEGMENT DYSGENESIS 7Pxn
anterior uveitisCcl2
Anti-Glomerular Basement Membrane DiseaseCcl2 , Mapk14 , Ptk2b
Aortic Aneurysm, AbdominalCav1 , Ccl2 , Itgav , Ptgs2
Aortic Valve StenosisPpp3cb , Ptpn11
Aortic Valve, Calcification ofAkt1 , Ptgs2
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmias, CardiacPtgs2
Arterial Occlusive DiseasesItgb3
Arterial ThrombosisHif1a
ArteriosclerosisCcl2 , Itgb3 , Kdr , Nos3 , Ptgs2
Arteriovenous FistulaNos3 , Vegfa
Arthritis, ExperimentalAkt1 , Cbl , Ccl2 , Cdc42 , Flt1 , Hif1a , Itgb3 , Nos3 , Nras , Pgf , Pik3cd , Ptgs2 , Vegfa
Arthritis, RheumatoidCcl2 , Hif1a , Hsp90aa1 , Hspb1 , Pgf , Ptgs2 , Ptk2 , Vegfa
AsphyxiaHif1a
asphyxia neonatorumPtgs2
asthmaCcl2 , Hif1a , Itgb3 , Kdr , Nos3 , Pgf , Pla2g4a , Ptgs2 , Rhoa , Vegfa
Asthma, Aspirin-InducedPtgs2
Asthma, OccupationalPla2g4a , Prkca , Ptgs2
astrocytomaAkt1 , Braf , Hif1a , Kras , Map2k3 , Ptpn11
Ataxia-Oculomotor Apraxia 3Pik3r5
atherosclerosisAkt1 , Cav1 , Ccl2 , Egln1 , Kdr , Nos3 , Pgf , Pla2g2a , Ptgs2 , Vegfa , Vegfc
Atrial FibrillationCav1 , Flt1 , Hif1a , Nos3 , Vegfa
AtrophyMapk3
Attention Deficit Disorder with HyperactivityVegfa
Autism Spectrum DisorderItgb3 , Mapk11 , Mapk12 , Mapk3
Autistic DisorderCcl2 , Hras , Itgb3 , Nrp2 , Pla2g4a , Prkcb , Ptgs2
autoimmune lymphoproliferative syndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
autosomal dominant mental retardation 19Ctnnb1
BacteremiaCcl2 , Mapkapk3
Bacterial InfectionsCasp9
Banti's SyndromeItgb3
Bardet-Biedl SyndromeAkt3
Barrett esophagusPtgs2
basal cell carcinomaPik3ca
Behcet SyndromeCcl2 , Nos3 , Vegfa
Benign Skin NeoplasmsHras
bipolar disorderAkt1 , Ccl2 , Cdc42 , Ptgs2
bladder carcinomaHras
bladder urothelial carcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Map2k1 , Nras , Pik3ca
blindnessVegfa
blood platelet disordersPla2g4a
Bone NeoplasmsPtgs2
Brain DeathMap2k6
Brain EdemaVegfa
Brain InjuriesAkt1 , Bad , Ccl2 , Hspb1 , Kdr , Ppp3ca , Ptgs2 , Rhoa , Vegfa , Vegfb
Brain IschemiaAkap1 , Akt1 , Bad , Casp9 , Cav1 , Ccl2 , Hif1a , Kdr , Map2k1 , Mapk1 , Mapk3 , Nos3 , Pgf , Pla2g4a , Prkaca , Prkca , Prkcd , Ptgs2 , Ptk2b , Src
Brain NeoplasmsBraf , Ctnnb1 , Hras , Iqgap1 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Vegfa
breast adenocarcinomaAkt1 , Kras , Pik3ca
breast cancerAkt1 , Braf , Grb2 , Hras , Pik3ca , Rhoa , Rock1
breast cancer, familialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Arf1 , Bad , Braf , Casp9 , Cav1 , Cdh5 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hras , Hsp90aa1 , Kdr , Kras , Map2k1 , Map2k2 , Map2k3 , Mapk1 , Nos3 , Pak2 , Pdpk1 , Pgf , Pik3ca , Pik3r1 , Pla2g4a , Plcg1 , Prkaa1 , Prkca , Ptgs2 , Ptk2 , Ptk2b , Raf1 , Rhoa , Rock1 , Src , Vegfa , Vegfb , Vegfc
Bronchial HyperreactivityCcl2 , Itgb3 , Nos3
bronchiolitis obliteransCcl2 , Nos3
Bronchitis, ChronicVegfa
Bronchopulmonary DysplasiaFlt1 , Hif1a
bullous pemphigoidVegfa
Burkitt LymphomaPik3r1
BurnsBad , Fyn , Hif1a , Pla2g4a , Prkcd , Ptgs2
CachexiaPtgs2
CalcinosisCcl2 , Ctnnb1 , Ptpn6
CarcinogenesisBraf , Kras
CarcinomaCdc42 , Hif1a , Hras , Kras , Pik3r1 , Ptgs2 , Rhoa
Carcinoma in SituAkt1 , Ctnnb1 , Ptgs2
Carcinoma, DuctalHif1a
Carcinoma, Ductal, BreastAkap1 , Akt1 , Hif1a , Ptgs2
Carcinoma, HepatocellularAkt1 , Akt2 , Braf , Ctnnb1 , Hif1a , Hras , Hspb1 , Iqgap1 , Kras , Nras , Pik3ca , Ptgs2 , Ptk2 , Rac1
Carcinoma, Intraductal, NoninfiltratingFlt1 , Hif1a , Pak2 , Prkca , Ptgs2 , Ptk2 , Src , Vegfa
Carcinoma, Large CellPrkca
Carcinoma, LobularCtnna1 , Ctnnb1
Carcinoma, PapillaryVegfc
Carcinoma, Renal CellAkt1 , Akt3 , Bad , Cav1 , Ctnna1 , Ctnnb1 , Egln1 , Egln2 , Egln3 , Flt1 , Hif1a , Hspb1 , Kdr , Kras , Map2k1 , Mapk1 , Nras , Pgf , Pik3ca , Pik3r1 , Ptgs2 , Vegfa , Vegfc
Carcinoma, Squamous CellAkt1 , Cav1 , Ccl2 , Hras , Hspb1 , Kdr , Kras , Mapk1 , Mapk3 , Pik3ca , Ptgs2 , Ptk2 , Ptpn11 , Vegfa
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Ctnnb1 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Ptgs2 , Rac1 , Rhoa
Carcinoma, Transitional CellAkt1 , Braf , Cav1 , Ctnna1 , Ctnnb1 , Hras , Kdr , Kras , Map2k1 , Mapk1 , Nras , Pik3ca , Pla2g4a , Ptgs2
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Cav1 , Hif1a , Map2k6 , Mapk1 , Nos3 , Ppp3ca , Prkaa2 , Prkca , Prkcb , Prkcd , Prkcz , Rac1 , Raf1 , Rhoa , Src
cardiomyopathyAkt1 , Ccl2 , Kras , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Nos3 , Prkaa2 , Ptgs2 , Vcl , Vegfa
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, Dilated, 1sVcl
Cardiomyopathy, Dilated, 1wVcl
Cardiomyopathy, Familial Hypertrophic, 4Braf
Cardiomyopathy, HypertrophicCtnnb1 , Hspb1 , Prkaca , Ptpn11 , Raf1 , Vcl
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Vcl
Cardiomyopathy, RestrictiveMap2k3 , Map2k6 , Mapk14 , Prkcd
CardiotoxicityNos3 , Rac1
Cardiovascular AbnormalitiesMap2k1
cardiovascular system diseaseCcl2 , Nos3 , Ptgs2
Carotid Artery DiseasesCcl2 , Pgf
Carotid Artery InjuriesCbl , Ccl2 , Itgb3 , Nos3
Carotid Artery ThrombosisItgb3
carotid stenosisItgb3
Carrington syndromeCcl2
CatalepsyFyn
CataractMap2k1
cavernous hemangioma, central nervous systemFlt1 , Kdr
Cecal NeoplasmsCtnnb1 , Kras
Cell Transformation, NeoplasticHras , Kras , Ptk2 , Pxn , Rac1
centronuclear myopathy, 1Dnm2
centronuclear myopathy, X-linkedDnm2
Cerebral HemorrhageFlt1 , Itgav , Itgb3 , Kdr , Ptgs2 , Vegfa
Cerebral InfarctionNos3
ceroid lipofuscinosis, neuronal 6Mapk1 , Mapk3
cervical intraepithelial neoplasiaCtnna1 , Ptgs2 , Vegfa
Chagas DiseaseCcl2
Charcot-Marie-Tooth DiseaseDnm2 , Hspb1
Charcot-Marie-Tooth disease intermediate typeDnm2
Charcot-Marie-Tooth Disease, Dominant Intermediate BDnm2
Charcot-Marie-Tooth Disease, Type 2FHspb1
Chemical and Drug Induced Liver InjuryBad , Ccl2 , Ctnnb1 , Flt1 , Ptgs2
Child Behavior DisordersNos3
cholangiocarcinomaKras , Prkaca , Ptgs2
CholecystolithiasisPla2g2a
CholestasisMapk13 , Mapk14 , Nos3
Cholestasis, ExtrahepaticMapk1 , Mapk3
CholesteatomaVegfa
Cholesteatoma, Middle EarHif1a , Vegfa
Choroidal NeovascularizationCcl2 , Flt1 , Itgav , Kdr , Vegfa , Vegfb
Chronic Cerebral HypoperfusionHif1a , Mapk14
Chronic Lymphoid LeukemiaBraf , Hras , Kras , Nras , Plcg2 , Ptpn11
chronic myeloid leukemiaBraf , Mapk14 , Nras , Vegfa
chronic periodontitisCcl2 , Rac2
chronic relapsing experimental autoimmune encephalomyelitisCcl2
Churg-Strauss SyndromeVtn
Cleft LipNos3
cleft palateNos3
Cocaine-Related DisordersCalm1 , Calm2 , Mapk1 , Mapk3
Cognition DisordersMapk14 , Ptgs2
Cognitive DysfunctionHsp90aa1
ColitisCcl2 , Kdr , Nos3 , Pgf , Pla2g2a , Ptgs2 , Src
Colitis, ExperimentalKdr , Vegfa
Colitis, IschemicVegfa
colon adenomaRac1
colon cancerAkt1 , Braf , Ctnnb1 , Flt1 , Flt4 , Kdr , Nras , Pik3ca , Pla2g2a , Ptprj
colon carcinomaAkt1 , Braf , Ctnnb1 , Flt1 , Flt4 , Kdr , Nras , Pik3ca , Ptprj
Colonic NeoplasmsAkt1 , Akt2 , Akt3 , Bad , Braf , Ccl2 , Ctnnb1 , Flt1 , Flt4 , Hif1a , Hspb1 , Kdr , Kras , Map2k3 , Map2k6 , Nras , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Pla2g2a , Prkaa1 , Ptgs2 , Ptprj , Src , Vegfa , Vegfc
colorectal cancerAkt1 , Braf , Ctnnb1 , Flt1 , Flt4 , Kdr , Nras , Pik3ca , Ptprj , Rac1 , Rhoa
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Casp9 , Cdh5 , Ctnnb1 , Hras , Itgb3 , Kdr , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Pla2g2a , Prkcb , Ptgs2 , Ptpn11 , Ptprj , Raf1 , Rhoa , Src
congenital generalized lipodystrophy type 3Cav1
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congenital myopathy, with excess of muscle spindlesHras
Constriction, PathologicItgb3
ContusionsCcl2
Corneal NeovascularizationFlt1 , Itgav , Kdr , Vegfa
Coronary Artery DiseaseAkt1 , Ccl2 , Cdh5 , Nos3 , Ptgs2 , Vegfa , Vtn
Coronary Artery Disease, Development of, in HIVCcl2
Coronary DiseaseFlt1 , Itgb3 , Kdr , Vegfa
coronary restenosisMapk1
Coronary StenosisItgav
Coronary ThrombosisItgb3
Coronary VasospasmNos3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
CoughPtgs2
Cowden diseaseAkt1 , Pik3ca
COWDEN SYNDROME 5Pik3ca
Cowden-Like SyndromeAkt1 , Pik3ca
Craniofacial AbnormalitiesCtnnb1
CraniopharyngiomaBraf , Ctnnb1
Creutzfeldt-Jakob SyndromePtgs2
Crohn DiseaseCcl2 , Kdr , Pgf , Ptgs2 , Vegfa , Vtn
Cryopyrin-Associated Periodic SyndromesPlcg2
CryptococcosisCcl2
CryptorchidismCbl , Ptgs2
Currarino TriadPik3ca
cutaneous malignant melanoma, susceptibility to, 1Akt1 , Braf , Cbl , Ctnnb1 , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Rac1 , Raf1 , Vcl
Cystic FibrosisCcl2 , Nos3 , Ptgs2
CystitisKdr , Ptgs2
Death, Sudden, CardiacItgb3
Dementia, VascularFlt1
demyelinating diseasePtgs2
Dermal FibrosisCav1
DermatitisPla2g4a
Dermatitis HerpetiformisVegfa
Dermatitis, Allergic ContactFlt1 , Kdr , Vegfa
Dermatitis, ContactCcl2 , Hsp90aa1 , Hspb1 , Kdr , Vegfa
Desmoid Disease, HereditaryCtnnb1
Developmental DisabilitiesAkt3 , Cbl , Pik3r2
Diabetes ComplicationsHif1a , Prkaa1 , Vegfa
Diabetes Insipidus, NephrogenicPrkca
Diabetes MellitusCav1 , Ptgs2 , Rac1
diabetes mellitus, experimentalAkt1 , Bad , Casp9 , Cav1 , Ccl2 , Flt1 , Hif1a , Hras , Hsp90aa1 , Itgb3 , Kdr , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Nos3 , Nrp1 , Pgf , Pik3r1 , Plcg1 , Prkca , Prkcb , Prkcd , Ptgs2 , Rhoa , Vegfa , Vegfb
Diabetes, GestationalCcl2
Diabetic AngiopathiesCcl2 , Nos3 , Ptk2b , Vegfa
Diabetic CardiomyopathiesBad , Nos3
Diabetic CystopathyBad
Diabetic GastroparesisNos3
Diabetic NephropathiesCcl2 , Flt1 , Hif1a , Hspb1 , Kdr , Mapk1 , Mapk14 , Nos3 , Pgf , Prkcb , Ptgs2 , Vegfa , Vtn
Diabetic NeuropathiesBad , Cav1 , Mapk14 , Pgf , Ptgs2 , Vegfa
Diabetic RetinopathyCasp9 , Ccl2 , Flt1 , Hif1a , Hras , Itgb3 , Nos3 , Pgf , Vegfa , Vtn
dilated cardiomyopathyEgln1 , Kras , Nfatc4 , Pgf , Ppp3r1 , Prkca , Prkcb , Ptpn11 , Rac1 , Raf1 , Vcl
DiseaseCtnnb1
Disease Models, AnimalAkt1 , Kras , Mapk1 , Mapk3 , Prkcg , Rhoa
Disease ProgressionCtnnb1 , Flt1 , Hras , Pik3ca , Prkab1 , Vegfb
distal hereditary motor neuropathy, type IHspb1
drug-induced enteropathyNos3
Drug-Related Side Effects and Adverse ReactionsPtgs2
duodenal ulcerPla2g4a , Ptgs2 , Vegfa
Dysembryoplastic Neuroepithelial TumorBraf
Dystonia 12Pla2g6
EdemaCasp9 , Map2k6 , Ptgs2
EnchondromatosisPtpn11
Endodermal Sinus TumorCtnnb1
endometrial carcinomaKras , Pik3ca
endometrial hyperplasiaKras , Ptk2
Endometrial NeoplasmsAkt2 , Bad , Braf , Ccl2 , Ctnna1 , Ctnnb1 , Flt1 , Grb2 , Kdr , Kras , Mapk1 , Mapk3 , Nos3 , Pik3ca , Pik3cb , Pik3cd , Prkca , Ptgs2 , Ptk2 , Vegfa
endometrioid carcinomaAkt1 , Ctnnb1 , Kdr , Kras , Pik3r2
EndometriosisCcl2 , Kdr , Kras , Nrp1 , Pla2g2a , Ptgs2 , Ptk2 , Vegfa
Endomyocardial FibrosisCcl2
EndotoxemiaCcl2 , Itgb3 , Mapk14 , Nos3 , Pgf , Prkaa1 , Ptgs2
endotoxin-induced uveitisCcl2
epidermal nevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1 , Pgf
Epilepsy, Temporal LobeCdc42 , Fyn , Kdr , Pgf , Vegfa
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOODPpp3ca
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1Ppp3ca
Erectile DysfunctionAkt1 , Bad , Kdr , Nos3 , Vegfa
Erythema MultiformeVegfa
Erythrocytosis, Familial, 3Egln1
esophageal carcinomaCtnnb1 , Hras , Kras , Pik3ca , Rhoa
Esophageal NeoplasmsCtnna1 , Ctnnb1 , Hras , Kdr , Kras , Nos3 , Pik3ca , Ptgs2 , Rhoa
esophageal squamous cell carcinomaCtnnb1 , Hif1a , Ptgs2
EsophagitisPtgs2
essential hypertensionNos3
Exfoliation SyndromeCav1
experimental autoimmune myocarditisCav1 , Ccl2
Experimental Autoimmune OrchitisCcl2
Experimental Encephalomyelitis, AutoimmuneCasp9 , Ccl2 , Flt1 , Kdr , Prkaa1 , Ptgs2 , Rhoa , Vegfa
Exudative vitreoretinopathy 1Ctnnb1
Eye NeoplasmsCcl2
Facial AsymmetryPik3ca
Failure to ThrivePtpn11
familial cold autoinflammatory syndrome 3Plcg2
familial partial lipodystrophyAkt2 , Cav1
Familial Primary Pulmonary HypertensionCav1
Fatty LiverCcl2 , Prkaa1 , Prkcd , Ptgs2
Febrile NeutropeniaCcl2
Fetal DiseasesPrkcb
Fetal Growth RetardationNos3 , Ptgs2 , Ptpn11
FeverHspb1 , Pla2g4a , Ptgs2
FibrosarcomaCdc42
FibrosisAkt1 , Ptgs2 , Rhoa , Sphk1
Fleck Retina, Familial BenignPla2g5
focal segmental glomerulosclerosisHspb1 , Itgb3 , Ppp3ca , Ppp3cb
Fractures, BonePtgs2
Frontotemporal Lobar DegenerationHsp90aa1
fungal infectious diseaseCcl2
gallbladder neoplasmsKras , Ptgs2
gastric ulcerBad , Nos3 , Ptgs2 , Vegfa
GastritisCcl2 , Ptgs2
gastroesophageal refluxPla2g2a , Ptgs2
Gastrointestinal NeoplasmsPik3ca
Gastrointestinal Stromal TumorsBraf , Ctnna1 , Kras
Genetic Diseases, InbornCav1 , Cdc42 , Ctnnb1 , Egln1 , Mapk1 , Pik3r2 , Pla2g6
Geographic AtrophyCcl2
GerminomaBraf
Giant Cell ArteritisCcl2
Giant Pigmented Hairy NevusHras , Nras
GingivitisVegfa
Glanzmann Thrombasthenia, Autosomal DominantItgb3
GlaucomaBad , Vegfa
Glaucoma, NeovascularVegfa
Glaucoma, Open-AngleCav1 , Ptgs2
Glaucoma, Primary Open AngleCav1 , Nos3
glioblastomaAkt1 , Braf , Hif1a , Hras , Map2k3 , Nras , Pgf , Pik3ca , Pik3r1 , Ptgs2 , Ptk2 , Vegfa
gliomaAkt2 , Bad , Braf , Cav1 , Kdr , Nos3 , Pik3ca , Ptgs2 , Raf1 , Sphk1
GliosarcomaCcl2 , Ptgs2 , Vegfa
GliosisItgb3 , Mapk1 , Mapk3
GlomerulonephritisCcl2 , Itgb3 , Mapk1 , Ptk2b , Vegfa
Glomerulonephritis, CrescenticCcl2
Glomerulonephritis, IGACcl2
Glomerulonephritis, MembranoproliferativeCcl2
Glomus Tympanicum TumorVegfa
Glucose IntolerancePrkaa1 , Prkaa2
Graft Occlusion, VascularNos3
Graft vs Host DiseaseVegfa
Granuloma, Respiratory TractCcl2
Granulomatosis with PolyangiitisVtn
Granulomatous Interstitial NephritisCcl2
Granulomatous VasculitisCcl2
Granulosa Cell TumorCtnnb1 , Ptgs2 , Vegfa
Graves DiseaseItgb3 , Vegfa
Graves OphthalmopathyCcl2 , Ptgs2
Growth DisordersCbl , Pik3ca
Growth Hormone-Secreting Pituitary AdenomaPtgs2 , Ptpn11
Guillain-Barre SyndromeCcl2
Hand-Foot SyndromeKdr
Hantavirus InfectionsItgb3
head and neck neoplasmsMapk1 , Mapk3 , Pik3ca , Vegfa
Hearing Loss, Noise-InducedCcl2 , Hif1a
Hearing Loss, SensorineuralPrkcb
Hearing Loss, SuddenNos3
Heart ArrestAkt1
Heart Defects, CongenitalHif1a , Vegfa
Heart DiseasesCasp9 , Mapk14 , Rac2 , Vegfa
Heart FailureCbl , Ccl2 , Hif1a , Hspb1 , Nos3 , Pdpk1 , Pgf , Prkaca , Prkca , Prkcb , Ptgs2 , Rac1 , Vegfa
Heart Septal Defects, VentricularBraf , Pgf
Heart Valve DiseasesCcl2 , Ptpn6
HemangioblastomaHif1a
Hemangioma, CapillaryAkt3
Hemangioma, Capillary InfantileFlt4 , Kdr
hemangiosarcomaCtnnb1 , Flt1 , Hras , Kdr , Kras , Plcg1 , Vegfa , Vegfc
HemarthrosisCcl2
Hematologic NeoplasmsCbl
HemimegalencephalyPik3ca
Hemolytic-Uremic SyndromeCcl2
HemorrhageCav1 , Itgb3
Hemorrhagic DisordersItgb3
Hemorrhagic Fever with Renal SyndromeItgb3
Hepatic EncephalopathyHif1a
Hepatitis, AutoimmuneCcl2
hepatoblastomaCtnnb1
Hepatoblastoma Caused By Somatic MutationCtnnb1
hepatolenticular degenerationPpp3ca , Ppp3cb
hepatopulmonary syndromeNos3
hereditary multiple exostosesPtpn11
Hernia, DiaphragmaticNos3
Hernias, Diaphragmatic, CongenitalCbl , Nos3 , Rhoa , Vegfa
Herpes SimplexCcl2
Hip FracturesItgb3
Hirschsprung Disease 1Kdr , Nrp2
HIV InfectionsCcl2 , Cdc42 , Hsp90aa1 , Hsp90ab1 , Hspb1 , Pla2g2a , Ptgs2
Hot FlashesHif1a
human influenzaCcl2 , Ptgs2
Huntington's DiseaseCasp9 , Nos3 , Ppp3ca , Prkaa1 , Ptgs2
HydronephrosisPtgs2
hydrophthalmosFlt1 , Kdr
HyperalgesiaCcl2 , Hif1a , Map2k3 , Mapk1 , Mapk3 , Pla2g4a , Prkcb , Prkcg , Prkcz , Ptgs2 , Raf1
HypercholesterolemiaVegfa
HyperemiaEgln1 , Nos3 , Ptgs2
HyperglycemiaCbl , Itgav , Nos3 , Pla2g4a , Prkcb , Prkcz , Ptgs2
HyperhomocysteinemiaCcl2
hyperinsulinismCcl2 , Nos3 , Prkcd
HyperlipidemiasCcl2 , Nos3
HyperoxaluriaCcl2
HyperoxiaNos3
Hyperparathyroidism, SecondaryPtgs2
HyperplasiaAkt1 , Cav1 , Hif1a , Hspb1 , Pik3ca , Ptgs2 , Vegfa
Hypersensitivity, DelayedCcl2
HypertensionAkt1 , Akt2 , Bad , Cav1 , Ccl2 , Egln1 , Hif1a , Itgav , Kdr , Kras , Nos3 , Pgf , Pik3r1 , Prkca , Prkcb , Prkcd , Ptgs2 , Ptk2 , Ptk2b , Ptprj , Rhoa , Src , Vegfa
Hypertension Resistant to Conventional TherapyNos3
Hypertension, Pregnancy-InducedNos3
Hypertension, RenalNos3
Hypertension, RenovascularNos3
HypertriglyceridemiaNos3
hypertrophic cardiomyopathy 15Vcl
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularNfatc3 , Nfatc4 , Nos3 , Ppp3ca , Ppp3cb , Ppp3r1 , Prkca , Prkcb , Prkcd , Prkcz , Ptgs2 , Ptk2 , Ptk2b , Rac1 , Rhoa , Rock1
Hypertrophy, Right VentricularAkt1 , Nfatc3 , Nfatc4 , Nos3 , Ppp3ca , Ppp3cb , Prkca , Prkcd , Ptk2
Hypoglossal Nerve InjuriesPrkaca
HypoglycemiaAkt2 , Pik3r1
HypogonadismNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypothyroidismBad , Cav1 , Nos3
HypoxiaCcl2 , Nos3 , Pgf , Ptgs2
Hypoxia, BrainNos3
Hypoxia-Ischemia, BrainCcl2 , Hif1a , Kdr , Vegfa
Idiopathic Hypogonadotropic HypogonadismNras
Idiopathic Pulmonary FibrosisHif1a , Ptgs2
idiopathic thrombocytopenic purpuraItgb3
Immune System DiseasesPrkcb
Immunoblastic LymphadenopathyRhoa
immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
Immunodeficiency 8Mapk3
infarctionHif1a
Infarction, Middle Cerebral ArteryBad , Ccl2 , Hif1a , Sphk2
InfectionCtnnb1
Infertility, FemaleHsp90ab1 , Mapk1 , Mapk3
Infertility, MaleCbl , Nos3
InflammationAkt1 , Ccl2 , Pgf , Pla2g4a , Ptgs2 , Vegfa
Inflammatory Bowel DiseasesPlcg2 , Ptgs2 , Vegfa
influenzaCcl2
influenza in birdsPtgs2
inherited metabolic disorderPla2g4a
Insulin ResistanceAkt2 , Bad , Ccl2 , Nos3 , Pik3r1 , Pla2g1b , Prkaa1 , Prkaa2 , Prkcb , Prkcd , Prkcz , Ptk2b
Intellectual DisabilityKras , Prkcg
Intermittent ClaudicationBad
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCtnnb1 , Map2k1 , Map2k2 , Pla2g2a , Prkca , Prkcd
Intestinal ObstructionPtgs2
intestinal perforationNos3
Intestinal PolypsPtgs2
Intestinal Reperfusion InjuryCcl2 , Nos3
Intimal HyperplasiaNos3
Intracranial AneurysmCcl2 , Nos3
Intracranial Arteriovenous MalformationsFlt1 , Kdr , Kras , Vegfa
Intracranial HemorrhagesHspb1 , Nos3
Invasive Pulmonary AspergillosisCcl2 , Vegfa
Irritable Bowel SyndromeNos3
IschemiaAkt2 , Ccl2 , Flt1 , Itgav , Nos3 , Prkca , Ptk2 , Raf1
Jaundice, ObstructiveCcl2
juvenile arthritisKras , Mapk1 , Sh2d2a
Karak SyndromePla2g6
KeloidNedd4
Keratitis, HerpeticCcl2 , Kdr
Keratosis, SeborrheicPik3ca
Kidney DiseasesCcl2 , Mapk1 , Ppp3ca , Ptgs2
Kidney Failure, ChronicCcl2 , Itgb3 , Nos3 , Pgf , Ptgs2
kidney neoplasmsAkt1 , Braf , Flt1 , Kdr , Kras , Mapk1 , Mapk3 , Ptgs2 , Raf1
Kidney Reperfusion InjuryCcl2 , Egln1 , Egln3 , Hif1a , Nos3 , Src
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
LathyrismKdr
Learning DisordersVegfa
LeiomyomaCav1 , Nos3 , Ptk2
leiomyosarcomaFlt1 , Ptgs2
Leishmaniasis, CutaneousCcl2
LEOPARD SyndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
Lethal Congenital Contracture Syndrome 5Dnm2
LeukemiaBad , Nras , Prkcz , Ptpn11 , Sphk1
Leukemia, ExperimentalCbl , Nras
Leukemia, Hairy CellMap2k1
Leukemia, Megakaryoblastic, of Down SyndromeNras
Leukemia, MyeloidVegfa
Leukemia, Myeloid, AcuteCbl , Ccl2 , Ctnna1 , Hras , Hspb1 , Itgav , Itgb3 , Kras , Nos3 , Nras , Ptpn11 , Vegfa
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileCbl , Kras , Nras , Ptpn11 , Rac2
Leukemia, Promyelocytic, AcuteAkt1 , Nras
Leukemia-Lymphoma, Adult T-CellFyn , Nras , Plcg1 , Prkcb
LeukocytosisKras , Nras
Leukoplakia, OralPtgs2
Leydig Cell TumorFlt1
Limb IschemiaHif1a , Itgav , Nos3 , Vegfa
LipodystrophyCcl2
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
liver cancerAkt1 , Ctnnb1 , Hras , Kras , Nras , Pik3ca
Liver CirrhosisCcl2 , Ctnnb1 , Flt1 , Nos3 , Pgf , Vegfa , Vtn
Liver Cirrhosis, BiliaryCdh5 , Hif1a
Liver Cirrhosis, ExperimentalCav1 , Ccl2 , Cdh5 , Fyn , Iqgap1 , Itgb3 , Nos3 , Pgf , Pla2g12a , Pla2g4a , Prkcb , Prkcd , Ptgs2 , Ptk2 , Rac2 , Rhoa , Vegfa
Liver DiseasesCcl2 , Nrp1 , Rac1
Liver Diseases, AlcoholicCav1 , Hif1a
Liver Diseases, ParasiticKras
Liver FailureVegfa
Liver Failure, AcuteCcl2 , Nos3 , Ptgs2
Liver InjuryHspb1
Liver NeoplasmsAkt1 , Braf , Ctnnb1 , Egln3 , Hras , Kras , Map2k3 , Mapk14 , Nras , Pik3ca , Raf1
Liver Neoplasms, ExperimentalCtnnb1 , Hras , Kdr , Kras , Map2k1 , Mapk1 , Mapk3
Liver Reperfusion InjuryBad , Ccl2 , Nos3
Long QT SyndromeVcl
Long QT Syndrome 1Calm2 , Calm3
LONG QT SYNDROME 14Calm1
LONG QT SYNDROME 15Calm2
Low Tension GlaucomaCav1
Lower Extremity Deep Vein ThrombosisCcl2
lung adenocarcinomaAkt1 , Braf , Ctnnb1 , Hras , Hspb1 , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Ppp3ca , Ptpn11 , Raf1 , Rhoa
lung cancerBraf , Kras , Pik3ca , Rock1
Lung DiseasesCcl2 , Hif1a , Itgb3 , Nos3 , Ptgs2 , Vegfa
Lung Diseases, InterstitialCcl2
Lung InjuryCcl2
Lung NeoplasmsAkt1 , Braf , Ctnna1 , Ctnnb1 , Hras , Kras , Map2k3 , Mapk1 , Mapk14 , Mapk3 , Pik3ca , Ptgs2 , Raf1 , Rock1
Lung Reperfusion InjuryNos3
lung small cell carcinomaAkt1 , Pik3ca
lung squamous cell carcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Pik3ca , Ptpn11
Lupus Erythematosus, SystemicCcl2 , Pgf , Ptgs2
Lupus NephritisCcl2
lyme neuroborreliosisCcl2
LymphangiectasisRaf1
lymphangioleiomyomatosisNos3 , Vegfd
LymphangiomaFlt4 , Kdr
Lymphatic MetastasisCasp9 , Cav1 , Ctnna1 , Ctnnb1 , Kdr , Nos3 , Pdpk1 , Pik3ca , Pik3cb , Ptgs2 , Rhoa , Vegfa , Vegfc , Vegfd
LymphedemaFlt4 , Pgf
LYMPHEDEMA, HEREDITARY, IDVegfc
lymphocytic leukemia, chronic, B-cellBraf , Cbl , Hras , Kras , Nras , Plcg2 , Ptgs2 , Ptpn11
lymphomaKras , Nras , Rac2
Lymphoma, B-CellNras , Ptgs2
Lymphoma, Large B-Cell, DiffusePdpk1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Large-Cell, AnaplasticHsp90aa1
Lymphoma, Mantle-CellCtnnb1 , Pik3cd
Lymphoma, Non-HodgkinBraf , Map2k1 , Nras , Pik3ca , Rhoa
Lymphoma, T-CellAkt1 , Rhoa
Lymphoma, T-Cell, CutaneousBraf , Plcg1 , Rhoa
Lymphoma, T-Cell, PeripheralFyn , Rhoa
lymphopeniaCbl
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationBad , Ccl2 , Flt1 , Kdr , Vegfa
MACULAR DYSTROPHY, PATTERNED, 3Mapkapk3
macular retinal edemaCcl2 , Flt1 , Kdr , Nos3 , Vegfa
major depressive disorderCalm2
MalariaMapkapk3
Malformations of Cortical DevelopmentAkt3 , Hras , Pik3ca
Malformations of Cortical Development, Group IIPla2g4e
Mammary Neoplasms, AnimalCdc42 , Hras , Kdr , Map2k6 , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Cav1 , Cdc42 , Ctnnb1 , Hif1a , Hras , Itgb3 , Kdr , Map2k3 , Pik3r1 , Ptgs2 , Ptk2 , Vegfa
Mandibular NeoplasmsBraf
marijuana abuseAkt1 , Calm1 , Calm2
medulloblastomaCtnnb1 , Nras , Pik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Braf , Cav1 , Cbl , Ccl2 , Ctnnb1 , Flt1 , Hras , Kdr , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3r1 , Ptgs2 , Ptk2b , Rac1 , Rac2 , Raf1 , Vcl , Vegfa , Vegfc
Melanoma, Cutaneous MalignantHif1a
Melanoma, ExperimentalPxn
membranous glomerulonephritisRhoa
Memory DisordersHif1a , Sphk2 , Vegfa
Meningeal NeoplasmsAkt1
MeningiomaAkt1
mental depressionPla2g2a , Ptgs2
MENTAL RETARDATION, AUTOSOMAL DOMINANT 48Rac1
Mesothelioma, MalignantCtnnb1 , Raf1
Metabolic Syndrome XCcl2 , Itgav , Nos3 , Pla2g4a , Pla2g6 , Ptgs2 , Vegfa
metachondromatosisPtpn11
Micronuclei, Chromosome-DefectiveHif1a
Microsatellite InstabilityBraf
microvascular complications of diabetes, susceptibility to, 1Vegfa
microvascular complications of diabetes, susceptibility to, 2Vegfa
microvascular complications of diabetes, susceptibility to, 7Vegfa
Migraine DisordersNos3
Mouth DiseasesPtgs2
Mouth NeoplasmsCcl2 , Hras , Hspb1 , Kras , Nras , Pik3ca , Ptgs2 , Ptk2
Mucocutaneous Lymph Node SyndromeFlt1 , Vegfa
Multiple MyelomaBraf , Cbl , Ccl2 , Hras , Hspb1 , Kras , Nras , Pik3ca , Ptpn11 , Vegfa
Multiple Organ FailureCcl2 , Mapk1
Multiple SclerosisCav1 , Ccl2 , Hsp90ab1 , Rhoa , Sh2d2a , Vegfa
Muscular AtrophyAkt1 , Ctnnb1 , Hsp90ab1 , Nedd4
Muscular DiseasesPrkcd
Muscular Dystrophy, DuchenneCcl2 , Pla2g6
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TOCcl2
Mycobacterium Tuberculosis, Susceptibility To Infection ByMapkapk3
mycosis fungoidesHif1a
Myelodysplastic SyndromesCtnna1 , Hras , Itgb3 , Kras , Nras , Sphk1
Myeloproliferative DisordersCbl , Kras , Nras
Myocardial InfarctionAkt1 , Ccl2 , Egln1 , Egln3 , Flt1 , Hif1a , Itgb3 , Kdr , Map2k6 , Mapk1 , Nos3 , Pgf , Ptgs2 , Vegfa , Vegfb
Myocardial IschemiaCcl2 , Hif1a , Itgav , Kdr , Map2k3 , Mapk14 , Nedd4 , Nos3 , Pgf , Pla2g2a , Ppp3r1 , Prkcd , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Cbl , Ccl2 , Egln1 , Hif1a , Map2k6 , Mapk1 , Mapk14 , Nos3 , Prkcb , Prkcd , Ptgs2 , Rhoa , Vegfa
MyocarditisCcl2 , Ptgs2
Myofibrillar MyopathyDnm2
Myopathies, Structural, CongenitalDnm2
Nasal PolypsCcl2 , Kdr , Nos3 , Ptgs2 , Vegfa
Nasopharyngeal CarcinomaAkt2 , Kras , Pik3ca
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
NecrosisCdc42
necrotizing enterocolitisNos3
Nematode InfectionsPik3r1
NeointimaFlt1 , Iqgap1 , Ptk2b
Neoplasm InvasivenessArf1 , Ccl2 , Ctnnb1 , Hif1a , Hras , Mapk1 , Mapk3 , Ptk2 , Rhoa , Src
Neoplasm MetastasisAkt2 , Braf , Cav1 , Ccl2 , Ctnnb1 , Flt1 , Hsp90aa1 , Itgb3 , Kdr , Kras , Mapk1 , Mapk3 , Nos3 , Pik3ca , Pik3r3 , Ptgs2 , Ptk2 , Pxn , Rac1 , Rhoa , Src , Vegfa
Neoplasm Recurrence, LocalPtgs2 , Vegfa
neoplasmsBraf , Ctnnb1 , Hras , Kras , Map2k1 , Nos3 , Nras , Pik3ca , Pik3r1 , Ptgs2 , Src , Vegfa
Neoplasms, ExperimentalBraf , Hras , Kras , Nras , Vegfa
Neoplasms, Germ Cell and EmbryonalRhoa , Rock1
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryCtnna1 , Pik3ca
Neovascularization, PathologicKdr , Vegfa
NephritisCcl2 , Nos3 , Ptk2 , Ptk2b
Nephritis, HereditaryHras
Nephritis, InterstitialCcl2
Nephrogenic Fibrosing DermopathyCav1
Nephropathy, Chronic TubulointerstitialCcl2
Nephrosis, Puromycin AminonucleosidePak2
Nephrotic SyndromeNck1 , Nck2 , Ptgs2
Nerve DegenerationCtnnb1 , Mapk1 , Mapk3 , Vegfa
Nervous System DiseasesCasp9 , Nfatc2 , Ptgs2
Neural Tube DefectsCcl2
NeuralgiaKdr
neurilemmomaKdr
NeuritisDnm2
Neuritis, Autoimmune, ExperimentalCav1 , Hif1a , Ptgs2 , Rhoa
Neuroaxonal DystrophiesPla2g6
neuroblastomaHras , Kras , Nras , Pik3ca , Ptpn11
Neurocutaneous MelanosisNras
Neurodegeneration with brain iron accumulationPla2g6
Neurodegeneration with brain iron accumulation 2APla2g6
Neurodegeneration with brain iron accumulation 2BPla2g6
neurodegenerative diseasePla2g6
Neurodevelopmental DisordersCtnnb1 , Ptpn11
Neuroendocrine TumorsBraf
Neurofibromatosis 1Vegfa
neurofibromatosis 2Vegfa
NeurofibrosarcomaKdr , Nras , Vegfa
Neurogenic InflammationPtgs2
Neuronopathy, Distal Hereditary Motor, Type IIBHspb1
Neuropathy, PainfulCcl2
neurotoxicity syndromesPrkcd
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf , Pla2g6
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
No-Reflow PhenomenonCdh5 , Ctnnb1
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cbl , Hif1a , Hras , Itgb3 , Kras , Map2k1 , Nras , Pdpk1 , Pik3ca , Prkcb , Ptgs2 , Pxn , Raf1 , Vegfa
Nonarteritic Anterior Ischemic Optic NeuropathyItgb3
Nonproliferative Diabetic RetinopathyFlt1
Nonseminomatous Germ Cell TumorBraf
Noonan like syndromeCbl , Cdc42 , Ptpn11
Noonan SyndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1
Noonan syndrome 1Braf , Nras , Ptpn11
Noonan syndrome 3Hras , Kras , Ptpn11 , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
obesityAkap1 , Akt1 , Akt2 , Bad , Cav1 , Ccl2 , Nos3 , Pgf , Pik3r1 , Prkcb , Prkcd , Ptgs2 , Rhoa
Obesity, MorbidHif1a
Obsessive-Compulsive DisorderHras
Obstetric Labor, PrematureCcl2
olfactory esthesioneuroblastomaHif1a
Optic Nerve InjuriesRhoa
Optic Neuropathy, IschemicNos3
Oral Squamous Cell CarcinomaCcl2
Oral Submucous FibrosisPtgs2
OrchitisCcl2
Osseous Heteroplasia, ProgressiveCtnnb1
OsteoarthritisBad , Cav1 , Flt1 , Hif1a , Ptgs2
Osteoarthritis, ExperimentalFlt1
Osteoarthritis, KneeCtnnb1 , Hsp90aa1
OsteochondrodysplasiasFlt1 , Kdr , Vegfa
OsteochondromaPtpn11
OsteoporosisMapk14 , Vcl
Osteoporosis, PostmenopausalHif1a , Ptk2b
OsteosarcomaAkt1 , Vegfa
otitis mediaVegfa
Otitis Media with EffusionFlt1 , Kdr , Vegfa
ovarian cancerAkt1 , Ctnnb1 , Kras , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Camkk2 , Cav1 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hras , Kdr , Kras , Map2k1 , Map2k2 , Map2k6 , Mapk1 , Mapk3 , Nos3 , Pik3ca , Pik3r1 , Prkca , Ptgs2 , Ptk2 , Rhoa , Vegfa , Vegfc , Vegfd
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
overnutritionNos3
Oxygen-Induced RetinopathyCcl2 , Hif1a , Kdr , Vegfa
PainAkt1 , Ccl2 , Nos3 , Ptgs2
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaCtnnb1 , Hras , Kras , Map2k2 , Pik3ca
pancreatic carcinoma Kras
pancreatic ductal carcinomaKras , Ptgs2 , Vegfa
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic NeoplasmsAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Ctnnb1 , Hif1a , Hspb1 , Kdr , Kras , Nrp1 , Ptgs2 , Vegfb
pancreatitisCcl2 , Hsp90ab1 , Ppp3ca , Ptgs2
Pancreatitis, AcuteArf1
Pancreatitis, Acute NecrotizingCcl2
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
papillary thyroid carcinomaBraf
papillomaHras , Pla2g4a , Ptgs2
Papilloma, InvertedKdr , Vegfa
ParaplegiaAkt1
Parkinson's DiseaseAkt1 , Casp9 , Pla2g6
Parkinson's disease 23, autosomal recessivePla2g6
Parkinsonian DisordersBad , Casp9 , Prkcd , Ptgs2 , Src
Paroxysmal ventricular fibrillationVcl
Patterned Dystrophy of Retinal Pigment EpitheliumCtnna1 , Mapkapk3
patterned macular dystrophy 2Ctnna1
penile neoplasmsHras , Kras , Pik3ca
perennial allergic rhinitisCcl2 , Nos3
Peri-ImplantitisCcl2
Periapical PeriodontitisCcl2
Pericardial EffusionPtgs2
Periodontal AtrophyVegfa
Periodontal CystCcl2
PeriodontitisCcl2
Peripheral Nerve InjuriesCcl2 , Ptgs2
Peripheral Nervous System DiseasesCasp9 , Dnm2
Peritoneal NeoplasmsCtnnb1
Phencyclidine AbuseCalm1 , Calm2
Phobic DisordersHras
Phospholipase A2, Group IVA, Deficiency ofPla2g4a
Phyllodes TumorCtnnb1 , Hif1a , Nos3
Pick Disease of the BrainMap2k6
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
pilocytic astrocytomaKras
PilomatrixomaCtnnb1
pituitary neoplasmsPrkca
PlasmacytomaBraf , Hras , Kras , Nras , Pik3ca
Pleomorphic Xanthoastrocytoma Braf , Cav1 , Grb10 , Hspb1
Pleural DiseasesCcl2
PleurisyPla2g6 , Ptgs2
pneumocystosisCcl2
PneumoniaCcl2 , Itgb3
Pneumonia, BacterialCcl2 , Itgb3 , Pgf
Pneumonia, PneumococcalMapk1 , Mapk3
Polyarteritis NodosaVegfa
Polycystic Kidney DiseasesHif1a , Nos3 , Pla2g4a , Plcg1 , Ptgs2
Polycystic Kidney, Autosomal RecessiveAkt1 , Pik3ca , Src
Polycystic Ovary SyndromeFlt4 , Gab1 , Vegfa
PolycythemiaEgln1
PolymicrogyriaAkt3
Polymorphic Catecholergic Ventricular TachycardiaCalm1
Polypoidal Choroidal VasculopathyVegfa
PolyuriaPrkca
portal hypertensionHsp90aa1 , Nos3 , Pik3r1 , Prkcd , Ptgs2 , Vegfa
Posttransfusion PurpuraItgb3
Pre-EclampsiaFlt1 , Nos3 , Pgf , Vegfa
Precancerous ConditionsAkt1 , Hras , Ptgs2 , Vegfa
Precursor Cell Lymphoblastic Leukemia-LymphomaKras , Nos3 , Nras
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras , Ptpn11
Pregnancy in DiabeticsVegfa
Premature BirthPgf , Ptgs2
Prenatal InjuriesRock1
PresbycusisHspb1
Pressure UlcerHif1a , Kdr , Vegfa
primary polycythemiaEgln1
progressive supranuclear palsyMap2k6
prolactinomaPtgs2
Proliferative Diabetic RetinopathyCcl2 , Flt1 , Vegfa
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Ctnnb1 , Grb2 , Hras , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkap1 , Akt2 , Akt3 , Ctnnb1 , Grb2 , Hif1a , Kdr , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Ptgs2 , Rac2 , Raf1
prostate carcinomaAkt2
prostate carcinoma in situFlt1 , Kras , Map2k6 , Ptgs2
Prostatic HyperplasiaBad , Kdr , Ptgs2
prostatic neoplasmsAkt1 , Bad , Braf , Camkk2 , Casp9 , Cav1 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hsp90ab1 , Itgb3 , Kdr , Kras , Map2k1 , Map2k6 , Mapk3 , Nedd4 , Nos3 , Nras , Nrp1 , Pik3ca , Pik3cd , Pik3r1 , Ppp3ca , Prkca , Prkcz , Ptgs2 , Ptk2 , Ptk2b , Src , Vegfa
ProstatitisPtgs2
ProteinuriaNck1 , Nck2 , Pak2 , Ptgs2 , Rhoa , Vegfa , Vtn
Proteus SyndromeAkt1
Pseudoxanthoma ElasticumVegfa
psoriasisCav1 , Flt1 , Hif1a , Kdr , Vegfa
Psychoses, Substance-InducedAkt1
PterygiumKdr , Vegfa , Vegfc
Puberty, PrecociousPtgs2
Pulmonary AspergillosisCcl2
Pulmonary ContusionCcl2
Pulmonary Disease, Chronic ObstructiveCcl2 , Flt1 , Kdr , Nos3 , Ptgs2 , Vegfa
Pulmonary EdemaCcl2 , Nos3 , Vegfa
pulmonary embolismCcl2 , Nos3
Pulmonary EmphysemaCcl2 , Nos3 , Pgf , Ptgs2
pulmonary eosinophiliaNos3
Pulmonary FibrosisBad , Cav1 , Ccl2 , Hsp90ab1 , Ptgs2
pulmonary hypertensionCav1 , Ccl2 , Hif1a , Nfatc2 , Nos3 , Pgf , Ptgs2 , Ptk2 , Rhoa , Vegfb
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3 , Nos3
Pulmonary Hypertension, Primary, 3Cav1
Pulmonary Valve StenosisBraf , Hras
Purpura, Schoenlein-HenochCcl2
Purpura, ThrombocytopenicItgb3
PyelonephritisPgf
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalHif1a , Mapk1 , Mapk3 , Ptgs2
Radiation PneumonitisNos3 , Vtn
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1
rectal neoplasmsNras , Pik3ca , Pik3cb
RecurrenceFlt1 , Hras , Kras , Vegfc
renal carcinomaNras , Pik3ca
renal clear cell carcinoma Egln3 , Flt4 , Vegfa
Renal FibrosisKras , Mapk1
Renal InsufficiencyHif1a
Renal Insufficiency, ChronicNos3
Reperfusion InjuryAkt1 , Bad , Casp9 , Cav1 , Ccl2 , Cdc42 , Hif1a , Hspb1 , Itgb3 , Kdr , Nos3 , Pik3r1 , Pla2g2a , Pla2g4a , Ppp3ca , Ppp3cb , Prkca , Ptgs2 , Ptk2 , Ptk2b , Src , Vegfc , Vegfd
Respiratory HypersensitivityNos3 , Ptpn6
Retina Reperfusion InjuryBad , Ccl2 , Hspb1 , Nos3 , Vegfa
Retinal DegenerationCcl2 , Nos3
Retinal DetachmentCasp9 , Ccl2
Retinal DiseasesMap2k3 , Vegfa
Retinal DystrophiesCtnna1
Retinal IschemiaHif1a , Vegfa
Retinal NeovascularizationHif1a , Itgav , Vegfa , Vegfb
retinal telangiectasiaKdr , Vegfa
Retinal Vein OcclusionVegfa , Vegfb
RetinitisCcl2
Retinitis PigmentosaPrkcg , Vegfa
Retinopathy of PrematurityFlt1 , Kdr , Nos3 , Vegfa
RhabdomyosarcomaVegfa
Rhabdomyosarcoma, EmbryonalPtpn11
RhinitisCdc42 , Vegfa
Romano-Ward SyndromeCalm2 , Calm3
SarcoidosisPtgs2
sarcomaCcl2 , Hspb1 , Kdr , Pik3ca
Sarcoma, ExperimentalKras , Nras
Sarcoma, MyeloidKras
SarcopeniaCav1
SchizophreniaAkt1 , Ccl2 , Fyn , Kdr , Mapk3 , Pak2 , Pik3cb , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r2 , Ptgs2
Sciatic NeuropathyCav1 , Ccl2
Scleroderma, DiffuseKdr
Scleroderma, LimitedCav1 , Ccl2 , Kdr , Pgf
Scleroderma, SystemicCav1 , Ccl2 , Flt4 , Kdr , Ptgs2 , Vegfa
sclerosing cholangitisHif1a
seasonal allergic rhinitisKdr , Vegfa
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresBad , Nrp2 , Prkcd , Ptgs2 , Vtn
SeminomaHras , Kras , Vegfa
Senior Loken SyndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisBad , Ccl2 , Flt1 , Fyn , Mapk1 , Mapk3 , Nos3 , Pgf , Pla2g2a , Pla2g4a
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Mapk1 , Plcg1
Shock, HemorrhagicBad , Mapk1 , Nos3
SHORT SyndromePik3r1
sickle cell anemiaNos3 , Pgf
SilicosisCcl2 , Prkcb
Skin DiseasesPtgs2
Skin NeoplasmsAkt1 , Ctnnb1 , Flt1 , Hif1a , Hras , Ptgs2 , Ptk2b , Vegfa
Sleep Apnea, CentralNos3
Sleep Apnea, ObstructiveCcl2 , Nos3 , Ptgs2
sleep deprivationPtgs2
Small-For-Size SyndromeBad , Vegfa
Smith-Magenis syndromeAkap1 , Ccl2 , Grb2 , Hgs , Itgb3 , Map2k2 , Map2k3 , Map2k6 , Prkca , Sphk1 , Vtn
Spinal Cord CompressionCcl2 , Nos3
Spinal Cord InjuriesAkt1 , Cav1 , Cdc42 , Flt1 , Hif1a , Hsp90ab1 , Hspb1 , Kdr , Nos3 , Pla2g2a , Pla2g6 , Ptgs2 , Vegfa
Spinal Cord Reperfusion InjuryBad
Spinal DysraphismCcl2
Spinocerebellar Ataxia 14Prkcg
Spinocerebellar AtaxiasPrkcg
Spinocerebellar DegenerationsDnm2
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
sporadic papillary renal cell carcinomaBraf , Hras , Pik3ca
Squamous Cell Carcinoma of the TongueKdr
Status EpilepticusCcl2 , Hspb1 , Pgf , Prkcb , Ptgs2 , Ptk2b , Src , Vegfa
Stevens-Johnson SyndromeCav1 , Ctnnb1 , Nedd4
Stomach NeoplasmsCav1 , Ctnnb1 , Fyn , Hras , Hspb1 , Kras , Mapk1 , Mapk3 , Nos3 , Nras , Pik3ca , Prkaa1 , Prkab1 , Prkcb , Ptgs2 , Rhoa
StrokeAkt1 , Ccl2 , Ctnnb1 , Itgav , Itgb3 , Kdr , Nos3 , Pgf , Prkaa2 , Prkcd , Ptgs2 , Src , Vegfa
Subarachnoid HemorrhageHif1a , Nos3 , Ptgs2
Substance Withdrawal SyndromeMapk1 , Mapk3
Sudden Infant DeathVegfa
Tachycardia, VentricularNos3 , Ppp3ca , Raf1
Takenouchi-Kosaki SyndromeCdc42
TelangiectasisNos3
Temporomandibular Joint DisordersHif1a
TeratomaCtnnb1
Testicular DiseasesPpp3ca
testicular germ cell tumorHras
Testis Reperfusion InjuryHif1a , Nos3
tetralogy of FallotFlt4 , Ptpn11
ThrombastheniaItgb3
ThrombocytopeniaCcl2 , Itgb3
THROMBOCYTOPENIA 6Src
Thrombocytopenia, Neonatal AlloimmuneItgb3
ThromboembolismNos3
ThrombosisPik3cb , Ptgs2 , Vtn
Thrombotic MicroangiopathiesItgb3 , Nos3 , Vegfa
thymomaHras
thyroid cancer, follicularBraf , Hras , Nras
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid DiseasesCcl2
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccl2 , Hif1a , Hras , Kras , Map2k3 , Nras , Pik3ca , Ptgs2
Tibial FracturesPgf
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsHras , Hspb1 , Ptgs2 , Vegfa , Vegfc
transient cerebral ischemiaBad , Casp9 , Cav1 , Cbl , Ccl2 , Flt1 , Hif1a , Hspb1 , Itgb3 , Nos3
Transplant RejectionCcl2 , Kdr , Nos3
Trichilemmoma Hras
Trigeminal NeuralgiaMapk1 , Mapk3 , Prkcg
Tuberculosis, PulmonaryCcl2
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusCasp9 , Cbl , Ccl2 , Nos3
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Braf , Calm1 , Casp9 , Ccl2 , Flt1 , Hif1a , Kdr , Mapk1 , Mapk3 , Nos3 , Pik3cb , Pik3r1 , Prkaa1 , Prkaa2 , Prkcb , Prkcz , Ptgs2 , Sphk1 , Src , Vegfa
UlcerHif1a , Itgb3
ulcerative colitisKdr , Sphk1 , Vegfa
UremiaFlt1 , Kdr , Nos3 , Ptk2
ureteral obstructionAkt1 , Nos3 , Pak2
Urethral ObstructionMapk1
urinary bladder cancerAkt1 , Casp9 , Cav1 , Ctnna1 , Ctnnb1 , Hras , Kdr , Kras , Nedd4 , Nos3 , Prkca , Ptgs2 , Rhoa , Src , Vegfc , Vegfd
urinary bladder neck obstructionHif1a , Nos3 , Ptgs2
urinary bladder neoplasmHras , Kras
Urinary IncontinenceMapk1
Urologic NeoplasmsHif1a , Ptgs2 , Rhoa , Vegfa
uterine carcinosarcomaHras , Pik3ca , Pik3r1
uterine cervical neoplasmsAkt1 , Ctnna1 , Ctnnb1 , Flt1 , Hras , Kdr , Kras , Map2k3 , Map2k6 , Mapk1 , Nras , Pik3ca , Ptgs2 , Ptk2 , Vegfa
Uterine NeoplasmsBraf , Ctnnb1 , Flt1 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Rac1
uveal melanomaKdr , Vegfa
UveitisCcl2
Uveitis, Autoimmune, ExperimentalCcl2
Uveoretinitis, Autoimmune, ExperimentalCcl2
VaricoceleCasp9 , Hif1a
Vascular CalcificationCtnnb1
Vascular MalformationsPik3ca
Vascular System InjuriesIqgap1
VasculitisCbl , Nos3
Vasculitis of the SkinCcl2
Vaso-occlusive CrisisNos3
Vasospasm, IntracranialCcl2
Venous ThrombosisCcl2 , Itgb3 , Kdr , Nos3
Ventilator-Induced Lung InjuryAkt1 , Ptgs2
Ventricular Dysfunction, LeftRac1
Ventricular Dysfunction, RightNos3
Ventricular Fibrillation, Paroxysmal Familial, 1Vcl
Ventricular Premature ComplexesNos3
Ventricular tachycardia, catecholaminergic polymorphic, 1Calm1
Ventricular tachycardia, catecholaminergic polymorphic, 4Calm1
Vestibular DiseasesNos3
viral pneumoniaCcl2
Vulvar NeoplasmsNos3
Wallerian DegenerationPgf , Pla2g4a , Pla2g6
Weight GainCalm1 , Cav1 , Iqgap1 , Pik3ca
Werner SyndromeHif1a
Wernicke EncephalopathyPtgs2
Wet Macular DegenerationCcl2 , Flt1 , Kdr , Nos3 , Vegfa
Wilms tumorCtnnb1 , Flt1 , Hif1a , Ptgs2 , Vegfc
Wounds and InjuriesVegfa
Wounds, PenetratingPgf
Pathway Annotations Associated with Genes in the vascular endothelial growth factor signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItgb3
acebutolol pharmacodynamics pathwayCalm1 , Prkaca
acetylsalicylic acid pharmacodynamics pathwayPla2g4b , Ptgs2
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Camkk2 , Prkaa1 , Prkaa2 , Prkab1 , Prkag1
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Hras , Map2k2 , Map2k6 , Mapk1 , Mapk11 , Pdpk1 , Pik3ca , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1 , Prkaca
aldosterone signaling pathwayHsp90aa1 , Hsp90ab1 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
alpha-linoleic acid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 , Pla2g4a , Pla2g4b , Pla2g4e , Pla2g4f , Pla2g5 , Pla2g6
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered Reelin signaling pathwayFyn , Src
altered vascular endothelial growth factor signaling pathwayFlt4
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionKdr , Vegfa
altered vascular endothelial growth factor signaling pathway involving the main playersFlt4 , Kdr , Vegfa
altered Wnt signaling, canonical pathwayCtnnb1
Alzheimer's disease pathwayBad , Calm1 , Calm2 , Calm3 , Casp9 , Chp1 , Chp2 , Mapk1 , Mapk3 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588
amiodarone pharmacodynamics pathwayCalm1 , Prkaca
amlodipine pharmacodynamics pathwayCalm1 , Prkaca
amyotrophic lateral sclerosis pathwayBad , Casp9 , Chp1 , Chp2 , Map2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Rac1 , RGD1564956 , RGD1565588
androgen signaling pathwayHsp90aa1 , Hsp90ab1
angiotensin II signaling pathwayCcl2 , Pdpk1 , Pla2g6 , Prkcz
angiotensin II signaling pathway via AT2 receptorPtpn6
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1
antipyrine drug pathwayPla2g4b , Ptgs2
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chp1 , Chp2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , RGD1564956 , RGD1565588
arachidonic acid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 , Pla2g4a , Pla2g4b , Pla2g4e , Pla2g4f , Pla2g5 , Pla2g6 , Ptgs2
Arf family mediated signaling pathwayArf1 , Rac1
arginine and proline metabolic pathwayNos3
arrhythmogenic right ventricular cardiomyopathy pathwayCtnna1 , Ctnnb1 , Itgb3
atenolol pharmacodynamics pathwayCalm1 , Prkaca
autophagy pathwayHgs , Prkaa1 , Prkaa2
axitinib pharmacodynamics pathwayFlt1 , Flt4 , Kdr
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chp1 , Chp2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfat5 , Nfatc2 , Nfatc3 , Nfatc4 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkcb , Ptpn6 , Rac1 , Rac2 , Raf1 , RGD1560225 , RGD1564956 , RGD1565588
basal cell carcinoma pathwayCtnnb1
betaxolol pharmacodynamics pathwayCalm1 , Prkaca
bevacizumab pharmacodynamics pathwayFlt1 , Kdr , Vegfa
bile acid transport pathwayPrkaca
bisoprolol pharmacodynamics pathwayCalm1 , Prkaca
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
bupranolol drug pathwayCalm1 , Prkaca
bupranolol pharmacodynamics pathwayCalm1 , Prkaca
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Rac1
calcineurin signaling pathwayNfatc2 , Nfatc3 , Nfatc4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2
calcium signaling pathway via the calcium-sensing receptorRhoa
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3 , Chp1 , Chp2 , Nos3 , Plcg1 , Plcg2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkca , Prkcb , Prkcg , Ptk2b , RGD1564956 , RGD1565588 , Sphk1 , Sphk2
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3
carvedilol pharmacodynamics pathwayCalm1 , Prkaca
celecoxib pharmacodynamics pathwayPla2g4b , Ptgs2
celecoxib pharmacokinetics pathwayPtgs2
cell-extracellular matrix signaling pathwayItgb3 , Vtn
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz , Rac1 , Rac2 , Raf1 , Sphk2 , Vegfa , Vegfb , Vegfc , Vegfd
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ccl2 , Cdc42 , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkcb , Prkcd , Prkcz , Ptk2 , Ptk2b , Pxn , Rac1 , Rac2 , Raf1 , Rhoa , Rock1 , Shc2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Shc2
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rhoa
cortisol signaling pathwayHsp90aa1 , Hsp90ab1
cyclooxygenase mediated pathway of arachidonic acid metabolismPla2g4a , Ptgs2
cytokine mediated signaling pathwayFlt1 , Flt4 , Kdr , Vegfc , Vegfd
diclofenac pharmacodynamics pathwayPla2g4b , Ptgs2
diflunisal pharmacodynamics pathwayPla2g4b , Ptgs2
dilated cardiomyopathy pathwayItgb3 , Prkaca
diltiazem pharmacodynamics pathwayCalm1 , Prkaca
disopyramide pharmacodynamics pathwayCalm1 , Prkaca
dobutamine pharmacodynamics pathwayCalm1 , Prkaca
dopamine signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Prkaca , Src
doxorubicin pharmacokinetics pathwayNos3
E-cadherin signaling pathwayAkt1 , Akt2 , Cdc42 , Ctnna1 , Ctnnb1 , Fyn , Iqgap1 , Nck1 , Pik3ca , Pik3r1 , Plcg1 , Rac1 , Rhoa , Rock1 , Src , Vcl
eicosanoid signaling pathwayAkt1 , Fyn , Mapk11 , Mapk14 , Nos3 , Pik3r5 , Prkaca , Prkca , Prkcd , Prkcg , Prkcz , Rac1 , Rhoa , Rock1 , Src
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayCav1 , Cbl , Cdc42 , Dnm2 , Flt1 , Hgs , Hras , Kdr , Nedd4 , Prkcz , Rhoa , Src
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnna1 , Ctnnb1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Hsp90ab1
endothelin signaling pathwayAkt1 , Cdc42 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk14 , Mapk3 , Nfatc3 , Pla2g4a , Prkca , Prkcd , Prkcg , Ptk2b , Rac1 , Raf1 , Rhoa , Src
Entamoebiasis pathwayHspb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkaca , Prkca , Prkcb , Prkcg , Ptk2 , Vcl
ephrin - ephrin receptor bidirectional signaling axisCbl , Cdc42 , Fyn , Grb2 , Hras , Itgb3 , Map2k1 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Plcg1 , Pxn , Rac1 , Rhoa , Rock1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cbl , Gab1 , Grb2 , Hras , Hsp90aa1 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nck1 , Nck2 , Nras , Pak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Prkcz , Ptk2 , Ptpn11 , Ptpn6 , Ptprj , Raf1 , Shc2 , Src
eptifibatide pharmacodynamics pathwayItgb3
Erk5 MAPK signaling pathwaySh2d2a
erythropoietin signaling pathwayCbl , Gab1 , Grb2 , Hras , Mapk14 , Pik3r1 , Plcg1 , Plcg2 , Ptpn11 , Ptpn6
esmolol pharmacodynamics pathwayCalm1 , Prkaca
estrogen signaling pathwayHsp90aa1 , Hsp90ab1 , Src
ether lipid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 , Pla2g4a , Pla2g4b , Pla2g4e , Pla2g4f , Pla2g5 , Pla2g6
ether lipid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 , Pla2g4a , Pla2g4b , Pla2g4e , Pla2g4f , Pla2g5 , Pla2g6
etodolac pharmacodynamics pathwayPla2g4b , Ptgs2
etoposide pharmacodynamics pathwayPtgs2
etoposide pharmacokinetics pathwayPtgs2
Fabry disease pathwaySphk2
FasL mediated signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Fyn , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Map2k3 , Map2k6 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f ,