VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING PATHWAY (PW:0000243)

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Description

Vascular endothelial growth factor signaling pathway (VEGF) regulates vasculogenesis, angiogenesis, lymphanogiogenesis and vascular permeability as well as the migration of monocytes and macrophages and the recruitment of haematopoietic cells. Several VEGFs (five in mammals) bind to one or more of the three VEGF receptor tyrosine kinases (RTK) to accomplish these important vascular functions. By far, the best characterized receptor and the focus of this synopsis and diagram is Kdr also known as

Pathway Diagram:

Ariadne Genomics Inc. Flt4 --+> vasculogenesis/lymphangiogensis Prkcb --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Prkca --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Prkcz --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway DAG --+> Prkca DAG --+> Prkcb DAG --+> Prkcz the extracellular signal-regulated Raf/Mek/Erk signaling pathway --+> cell proliferation phosphatidylinositol 3-kinase-Akt signaling pathway --+> cell survival Plcg1 --+> PIP3 SHB --+> phosphatidylinositol 3-kinase-Akt signaling pathway Kdr --+> vasculogenesis/angiogensis Kdr p38 MAPK signaling pathway --+> actin remodeling Nck1 --+> p38 MAPK signaling pathway Flt1 --+> vascular permeability/monocyte migration/haematopoiesis Nrp2 Nrp1 vascular permeability/monocyte migration/haematopoiesis Ptk2 Plcg1 Fyn Nck1 Sh2d2a Prkca Prkcb Prkcz SHB Flt4 Figf Vegfc Flt1 Vegfa Pgf DAG Fyn ---- Nck1 Kdr ---- Sh2d2a Kdr --+> Plcg1 Flt1 ---- Vegfb Flt1 ---- Pgf Flt1 ---- Vegfa Flt4 ---- Vegfc Figf ---- Flt4 Kdr ---- Nck1 Kdr ---- SHB Kdr ---- Vegfa IP3 Nrp1 ---- Vegfa Nrp2 ---- Vegfa Ptk2 ---- SHB p38 MAPK signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway cell survival Vegfb cell proliferation PIP3 the extracellular signal-regulated Raf/Mek/Erk signaling pathway actin remodeling vasculogenesis/angiogensis vasculogenesis/lymphangiogensis
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Genes in Pathway:

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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap1 A-kinase anchoring protein 1 JBrowse link 10 76,151,013 76,183,987 RGD:6484113
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6484113
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 JBrowse link 12 39,253,409 39,302,601 RGD:6484113
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:1580560
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6484113
RGD:6907045
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6484113
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6484113
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:6484113
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:1334466
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:727754
RGD:1334466
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1334466
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
G Fes FES proto-oncogene, tyrosine kinase JBrowse link 1 142,174,648 142,183,884 RGD:6484113
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:1626621
RGD:6484113
RGD:2298727
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:727326
RGD:6484113
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:2298729
RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
G Grb10 growth factor receptor bound protein 10 JBrowse link 14 92,021,851 92,122,249 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6484113
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate JBrowse link 10 109,638,944 109,657,460 RGD:6484113
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:625724
RGD:2301848
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:6484113
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6907045
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 1 142,525,041 142,615,673 RGD:6484113
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:6484113
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6484113
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:729081
RGD:6907045
RGD:6484113
RGD:2301848
RGD:2298729
RGD:2298727
RGD:2292019
RGD:1626621
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6484113
RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6484113
RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6484113
RGD:6907045
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:6484113
RGD:6907045
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:6907045
G Myof myoferlin JBrowse link 1 256,585,410 256,734,727 RGD:6484113
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:2298729
RGD:6484113
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:6484113
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:6484113
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:6907045
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6907045
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:6907045
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:6907045
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6484113
RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1334463
RGD:6484113
RGD:2298727
G Nrp2 neuropilin 2 JBrowse link 9 69,496,875 69,609,802 RGD:6484113
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6484113
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:633657
RGD:2298727
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:6907045
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:6907045
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:6907045
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6907045
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:6907045
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6907045
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:2298729
RGD:6907045
RGD:6484113
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6907045
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6907045
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:6907045
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6484113
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:6484113
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 JBrowse link 7 140,489,499 140,506,925 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:2298729
RGD:6907045
RGD:6484113
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:2298729
RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:2298730
RGD:6484113
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:2298729
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6907045
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:2298729
RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:6484113
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6484113
RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
RGD:6907045
G RGD1560225 similar to nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 RGD:6907045
G RGD1564956 similar to calcium binding protein P22 JBrowse link 5 70,747,534 70,749,967 RGD:6907045
G RGD1565588 similar to calcium binding protein P22 JBrowse link 4 6,477,461 6,479,158 RGD:6907045
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6484113
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:6484113
G Sh2d2a SH2 domain containing 2A JBrowse link 2 187,218,851 187,225,000 RGD:2298729
RGD:6907045
RGD:6484113
G Shb SH2 domain containing adaptor protein B JBrowse link 5 60,970,650 61,077,881 RGD:6484113
G Shc2 SHC adaptor protein 2 JBrowse link 7 12,948,952 12,971,174 RGD:6907045
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6907045
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:6907045
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
RGD:6907045
G Vcl vinculin JBrowse link 15 3,455,211 3,544,738 RGD:6484113
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:625593
RGD:6907045
RGD:2301956
RGD:2301848
RGD:2298727
RGD:2292019
RGD:1626621
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:1334463
RGD:2298727
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:727326
RGD:6484113
RGD:2298727
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:727326
RGD:6484113
RGD:2298727
G Vtn vitronectin JBrowse link 10 65,767,960 65,771,040 RGD:6484113
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019

Pathway Gene Annotations

Disease Annotations Associated with Genes in the vascular endothelial growth factor signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCav1 , Ccl2 , Itgav , Ptgs2
Aberrant Crypt FociCtnnb1 , Mapk1 , Mapk3
Abnormalities, Drug-InducedRhoa
Abortion, SpontaneousPgf
acoustic neuromaCav1 , Vegfa
acquired immunodeficiency syndromeCcl2
Acute Anterior UveitisCcl2
acute chest syndromeNos3 , Vegfa
Acute Coronary SyndromeItgb3 , Vcl
acute kidney failureBad , Egln1 , Egln3 , Hif1a , Nos3 , Ptgs2 , Vegfa
Acute Liver FailureCasp9 , Ccl2 , Nos3 , Ptgs2
Acute Lung InjuryCav1 , Ccl2 , Flt1 , Kdr , Pla2g2a , Prkaa1 , Ptgs2 , Vegfa
acute myeloid leukemiaCbl , Ccl2 , Ctnna1 , Hras , Hspb1 , Itgav , Itgb3 , Kras , Nos3 , Nras , Ptpn11 , Vegfa
Acute Necrotizing PancreatitisCcl2
acute pancreatitisArf1
acute promyelocytic leukemiaAkt1 , Nras
Acute-Phase ReactionHif1a
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCtnnb1 , Kdr , Kras , Nos3 , Pik3ca , Ptgs2 , Ptpn11 , Sphk1 , Vegfa
adenoid cystic carcinomaHras , Kras , Map2k2 , Pik3ca
adenomaCtnnb1 , Kras
adrenal carcinomaBraf , Ctnnb1 , Nras , Pik3ca
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsCdc42 , Ctnnb1 , Prkaca , Ptgs2
Adrenal InsufficiencyPla2g2a
adrenocortical carcinomaBraf , Ctnnb1 , Nras , Pik3ca
adult respiratory distress syndromeCcl2 , Pla2g2a , Pla2g4a
adult T-cell leukemiaFyn , Nras , Plcg1 , Prkcb
adult-onset Still's diseaseVegfa
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
age related macular degenerationCcl2
aggressive periodontitisCcl2
AlbuminuriaNck1 , Nck2 , Ptgs2
Alcohol Withdrawal DeliriumPtgs2
Alcoholic Liver DiseasesCav1 , Hif1a
allergic conjunctivitisCcl2 , Pla2g2a
allergic contact dermatitisFlt1 , Kdr , Vegfa
allergic hypersensitivity diseaseCcl2 , Map2k6
Alzheimer's diseaseAkt1 , Bad , Calm1 , Casp9 , Cav1 , Cdc42 , Ctnnb1 , Fyn , Hif1a , Hras , Hsp90aa1 , Hspb1 , Mapk1 , Mapk14 , Mapk3 , Nos3 , Pik3r1 , Plcg1 , Plcg2 , Ppp3r1 , Prkcb , Ptgs2 , Vegfa
Alzheimer's disease 1Nos3
ameloblastomaBraf
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Bad , Casp9 , Kdr , Mapk14 , Pgf , Pla2g4a , Ptgs2 , Vegfa
amyotrophic lateral sclerosis type 1Vegfa
AnaphylaxisPtgs2
AnaplasiaHif1a
anaplastic large cell lymphomaHsp90aa1
anemiaCcl2 , Kras
angiosarcomaCtnnb1 , Flt1 , Hras , Kdr , Kras , Plcg1 , Vegfa , Vegfc
angle-closure glaucomaNos3
Animal Disease ModelsAkt1 , Kras , Mapk1 , Mapk3 , Prkcg , Rhoa
Animal Mammary NeoplasmsCdc42 , Hras , Kdr , Map2k6 , Pik3r1
ankylosing spondylitisPgf
AnorexiaPtgs2
anterior ischemic optic neuropathyNos3
ANTERIOR SEGMENT DYSGENESIS 7Pxn
anterior uveitisCcl2
anti-basement membrane glomerulonephritisCcl2 , Mapk14 , Ptk2b
aortic valve diseaseNos3
aortic valve stenosisPpp3cb , Ptpn11
Aortic Valve, Calcification ofAkt1 , Ptgs2
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arterial Occlusive DiseasesItgb3
Arterial ThrombosisHif1a
arteriosclerosisCcl2 , Itgb3 , Kdr , Nos3 , Ptgs2
Arteriovenous FistulaNos3 , Vegfa
arteriovenous malformations of the brainFlt1 , Kdr , Kras , Vegfa
AsphyxiaHif1a
asphyxia neonatorumPtgs2
Aspirin-Induced AsthmaPtgs2
asthmaCcl2 , Hif1a , Itgb3 , Kdr , Nos3 , Pgf , Pla2g4a , Ptgs2 , Rhoa , Vegfa
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hif1a , Hras , Kras , Map2k3 , Ptpn11
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Cav1 , Ccl2 , Egln1 , Kdr , Nos3 , Pgf , Pla2g2a , Ptgs2 , Vegfa , Vegfc
atrial fibrillationCav1 , Flt1 , Hif1a , Nos3 , Pak2 , Ptk2 , Vegfa
AtrophyMapk3
attention deficit hyperactivity disorderVegfa
autism spectrum disorderItgb3 , Mapk11 , Mapk12 , Mapk3
autistic disorderCcl2 , Ctnnb1 , Hras , Itgb3 , Mapk1 , Nrp2 , Pla2g4a , Prkcb , Ptgs2
autoimmune hepatitisCcl2
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 3Prkcd
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autoimmune thrombocytopenic purpuraItgb3
Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-AssociatedPlcg2
autosomal dominant mental retardation 48Rac1
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal recessive Alport syndromeHras
autosomal recessive nonsyndromic deafness 26Gab1
autosomal recessive Parkinson's disease 14Pla2g6
autosomal recessive polycystic kidney diseaseAkt1 , Pik3ca , Src
avian influenzaPtgs2
B-Cell Chronic Lymphocytic LeukemiaBraf , Cbl , Hras , Kras , Nras , Plcg2 , Ptgs2
B-cell lymphomaNras , Ptgs2
background diabetic retinopathyFlt1
BacteremiaCcl2 , Mapkapk3
bacterial infectious diseaseCasp9
bacterial pneumoniaCcl2 , Itgb3 , Pgf
Bannayan-Riley-Ruvalcaba syndromePik3ca
Banti's SyndromeItgb3
Bardet-Biedl syndromeAkt3
Barrett's esophagusPtgs2
basal cell carcinomaPik3ca
Behcet's diseaseCcl2 , Nos3 , Vegfa
bipolar disorderAkt1 , Ccl2 , Cdc42 , Ptgs2
bladder carcinomaHras
bladder neck obstructionHif1a , Nos3 , Ptgs2
bladder urothelial carcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Map2k1 , Nras , Pik3ca
blindnessVegfa
blood platelet diseasePla2g4a
Bone FracturesPtgs2
Bone NeoplasmsPtgs2
Brain DeathMap2k6
brain edemaVegfa
Brain HypoxiaNos3
Brain InjuriesAkt1 , Bad , Ccl2 , Hspb1 , Kdr , Ppp3ca , Ptgs2 , Rhoa , Vegfa , Vegfb
Brain Injuries, TraumaticBad , Ppp3r1 , Ppp3r2
brain ischemiaAkap1 , Akt1 , Bad , Casp9 , Cav1 , Ccl2 , Hif1a , Kdr , Map2k1 , Mapk1 , Mapk3 , Nos3 , Pgf , Pla2g4a , Prkaca , Prkca , Prkcd , Ptgs2 , Ptk2b , Src
Brain NeoplasmsBraf , Ctnnb1 , Hras , Iqgap1 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Vegfa
breast adenocarcinomaAkt1 , Kras , Pik3ca
breast cancerAkt1 , Braf , Cav1 , Grb2 , Hras , Kras , Pik3ca , Rhoa , Rock1
Breast Cancer, FamilialPik3ca , Pik3r3
breast ductal carcinomaAkap1
Breast NeoplasmsAkt1 , Akt2 , Arf1 , Bad , Braf , Casp9 , Cav1 , Cdh5 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hras , Hsp90aa1 , Kdr , Kras , Map2k1 , Map2k2 , Map2k3 , Mapk1 , Nos3 , Pak2 , Pdpk1 , Pgf , Pik3ca , Pik3r1 , Pla2g4a , Plcg1 , Prkaa1 , Prkca , Ptgs2 , Ptk2 , Ptk2b , Raf1 , Rhoa , Rock1 , Src , Vegfa , Vegfb , Vegfc
Bronchial HyperreactivityCcl2 , Itgb3 , Nos3
bronchiolitis obliteransCcl2 , Nos3
bronchiolo-alveolar adenocarcinomaKras
Bronchitis, ChronicVegfa
Bronchopulmonary DysplasiaCasp9 , Flt1 , Hif1a
Bruton-type agammaglobulinemiaPik3r1
bullous pemphigoidVegfa
Burkitt lymphomaPik3r1
BurnsBad , Fyn , Hif1a , Pla2g4a , Prkcd , Ptgs2
CachexiaPtgs2
calcinosisCcl2 , Ctnnb1 , Ptpn6
cancerBraf , Hras , Nras , Pik3ca , Pik3r1
cannabis abuseAkt1 , Calm1 , Calm2
capillary hemangiomaAkt3
Capillary Hemangioma, InfantileFlt4 , Kdr
CarcinogenesisBraf , Cav1 , Kras
carcinomaCdc42 , Hif1a , Hras , Kras , Pik3r1 , Ptgs2 , Rhoa
cardiac arrestAkt1
Cardiac ArrhythmiasPtgs2
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Cav1 , Hif1a , Map2k6 , Mapk1 , Nos3 , Ppp3ca , Prkaa2 , Prkca , Prkcb , Prkcd , Prkcz , Rac1 , Raf1 , Rhoa , Src
cardiomyopathyAkt1 , Ccl2 , Kras , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Nos3 , Prkaa2 , Ptgs2 , Vcl , Vegfa
CardiotoxicityNos3 , Rac1
Cardiovascular AbnormalitiesMap2k1 , Ptpn11
cardiovascular system diseaseCcl2 , Nos3 , Ptgs2
carotid artery diseaseCcl2 , Pgf
Carotid Artery InjuriesCbl , Ccl2 , Itgb3 , Nos3
carotid artery thrombosisItgb3
carotid stenosisItgb3
Carrington SyndromeCcl2
CatalepsyFyn
cataractCasp9 , Map2k1
catecholaminergic polymorphic ventricular tachycardiaCalm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
Cecal NeoplasmsCtnnb1 , Kras
Cell Transformation, NeoplasticHif1a , Hras , Kras , Ptk2 , Pxn , Rac1
central sleep apneaNos3
centronuclear myopathyDnm2
Centronuclear Myopathy 1Dnm2
Centronuclear Myopathy, X-LinkedDnm2
cerebral cavernous malformationFlt1 , Kdr
Cerebral HemorrhageCasp9 , Flt1 , Itgav , Itgb3 , Kdr , Ptgs2 , Vegfa
cerebral infarctionNos3
cervix uteri carcinoma in situCtnna1 , Ptgs2 , Vegfa
Chagas diseaseCcl2
Charcot-Marie-Tooth diseaseDnm2 , Hspb1
Charcot-Marie-Tooth disease axonal type 2FHspb1
Charcot-Marie-Tooth disease dominant intermediate BDnm2
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
Charcot-Marie-Tooth disease intermediate typeDnm2
Charcot-Marie-Tooth disease type 2Hspb1
Chemical and Drug Induced Liver InjuryBad , Ccl2 , Ctnnb1 , Flt1 , Ptgs2 , Vegfa
Child Behavior DisordersNos3
childhood pilocytic astrocytomaMapk1
cholangiocarcinomaKras , Prkaca , Ptgs2
cholecystolithiasisPla2g2a
cholestasisMapk13 , Mapk14 , Nos3
cholesteatomaVegfa
cholesteatoma of middle earHif1a , Vegfa
Choroidal NeovascularizationCcl2 , Flt1 , Itgav , Kdr , Vegfa , Vegfb
Chronic Cerebral HypoperfusionHif1a , Mapk14 , Nos3
chronic kidney diseaseNos3
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras , Plcg2 , Ptpn11
chronic myeloid leukemiaAkt1 , Braf , Mapk14 , Nras , Vegfa
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseCcl2 , Flt1 , Kdr , Nos3 , Ptgs2 , Vegfa
Chronic PancreatitisBad
Chronic PeriodontitisCcl2 , Rac2
Chronic Relapsing Experimental Autoimmune EncephalomyelitisCcl2
Chronic Tubulointerstitial NephropathyCcl2
Churg-Strauss syndromeVtn
clear cell renal cell carcinomaEgln3 , Flt4 , Vegfa
cleft lipNos3
cleft palateNos3
CLOVES syndromePik3ca
Cocaine-Related DisordersCalm1 , Calm2 , Mapk1 , Mapk3
cognitive disorderMapk14 , Ptgs2
Cognitive DysfunctionHsp90aa1
colitisCcl2 , Kdr , Nos3 , Pgf , Pla2g2a , Ptgs2 , Src
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3 , Rac1
colon adenomaRac1
colon cancerAkt1 , Braf , Ctnnb1 , Nras , Pik3ca , Pla2g2a , Ptprj , Src
colon carcinomaAkt1 , Braf , Ctnnb1 , Flt1 , Flt4 , Kdr , Nras , Pik3ca , Ptprj
Colonic NeoplasmsAkt2 , Akt3 , Bad , Braf , Ccl2 , Ctnnb1 , Hif1a , Hspb1 , Kdr , Kras , Map2k3 , Map2k6 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Prkaa1 , Ptgs2 , Src , Vegfa , Vegfc
colorectal adenocarcinomaMapk1 , Mapk3 , Raf1
colorectal adenomaRaf1
colorectal cancerAkt1 , Braf , Ctnnb1 , Nras , Pik3ca , Ptprj , Rac1 , Rhoa , Src
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Casp9 , Cdh5 , Ctnnb1 , Hras , Itgb3 , Kdr , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Pla2g2a , Prkcb , Ptgs2 , Ptpn11 , Ptprj , Raf1 , Rhoa , Src
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Pik3ca
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital diaphragmatic herniaCbl , Nos3 , Rhoa , Vegfa
congenital generalized lipodystrophy type 3Cav1
congenital heart diseaseHif1a , Ptpn11 , Vegfa
Congenital Myopathy, with Excess of Muscle SpindlesHras
congenital structural myopathyDnm2
congestive heart failureCbl , Ccl2 , Hif1a , Hspb1 , Nos3 , Pdpk1 , Pgf , Prkaca , Prkca , Prkcb , Ptgs2 , Rac1 , Vcl , Vegfa
contact dermatitisCcl2 , Hsp90aa1 , Hspb1 , Kdr , Vegfa
ContusionsCcl2
corneal neovascularizationFlt1 , Itgav , Kdr , Vegfa
coronary artery diseaseAkt1 , Ccl2 , Cdh5 , Nos3 , Ptgs2 , Vegfa , Vtn
Coronary Artery Disease, Development of, in HIVCcl2
coronary artery vasospasmNos3
Coronary DiseaseFlt1 , Itgb3 , Kdr , Vegfa
coronary restenosisMapk1
coronary stenosisItgav
coronary thrombosisItgb3
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
CoughPtgs2
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
Craniofacial AbnormalitiesCtnnb1
craniopharyngiomaBraf , Ctnnb1
crescentic glomerulonephritisCcl2
Creutzfeldt-Jakob diseasePtgs2
Crohn's diseaseCcl2 , Kdr , Pgf , Ptgs2 , Vegfa , Vtn
Cryopyrin-Associated Periodic SyndromesPlcg2
cryptococcosisCcl2
cryptorchidismCbl , Ptgs2
Currarino TriadPik3ca
cutaneous leishmaniasisCcl2
cutaneous T cell lymphomaBraf , Plcg1 , Rhoa
cystic fibrosisCcl2 , Nos3 , Ptgs2
cystic kidney diseaseDnm2
cystitisKdr , Ptgs2
decubitus ulcerHif1a , Kdr , Vegfa
Delayed HypersensitivityCcl2
demyelinating diseaseMapk1 , Ptgs2
Dermal FibrosisCav1
dermatitisPla2g4a
dermatitis herpetiformisVegfa
Developmental DisabilitiesAkt3 , Braf , Cbl , Pik3r2
Diabetes ComplicationsCasp9 , Hif1a , Prkaa1 , Vegfa
diabetes mellitusCav1 , Ptgs2 , Rac1
Diabetes Mellitus, Experimental Akt1 , Bad , Casp9 , Cav1 , Ccl2 , Flt1 , Hif1a , Hras , Hsp90aa1 , Itgb3 , Kdr , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Nos3 , Nrp1 , Pgf , Pik3r1 , Plcg1 , Prkca , Prkcb , Prkcd , Ptgs2 , Rhoa , Vegfa , Vegfb
diabetic angiopathyCcl2 , Nos3 , Ptk2b , Vegfa
Diabetic CardiomyopathiesBad , Casp9 , Ctnnb1 , Mapk1 , Mapk3 , Nos3
Diabetic CystopathyBad
Diabetic GastroparesisNos3
Diabetic NephropathiesCasp9 , Ccl2 , Flt1 , Hif1a , Hspb1 , Kdr , Mapk1 , Mapk14 , Nos3 , Pgf , Prkcb , Ptgs2 , Vegfa , Vtn
diabetic neuropathyBad , Cav1 , Mapk14 , Pgf , Ptgs2 , Vegfa
diabetic retinopathyCasp9 , Ccl2 , Flt1 , Hif1a , Hras , Itgb3 , Nos3 , Pgf , Vegfa , Vtn
Diaphragmatic HerniaNos3
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd
diffuse sclerodermaKdr
DiGeorge syndromeVegfa
dilated cardiomyopathyCasp9 , Ctnnb1 , Egln1 , Kras , Nfatc4 , Pgf , Ppp3ca , Ppp3r1 , Prkca , Prkcb , Ptpn11 , Rac1 , Raf1 , Vcl
dilated cardiomyopathy 1NNRaf1
dilated cardiomyopathy 1SVcl
dilated cardiomyopathy 1WVcl
Dilated Cardiomyopathy with Left Ventricular NoncompactionVcl
diseaseCtnnb1
disease of cellular proliferationBraf , Ctnnb1 , Hras , Kras , Map2k1 , Nos3 , Nras , Pik3ca , Pik3r1 , Ptgs2 , Src , Vegfa
disease of metabolismPtpn11
Disease ProgressionCtnnb1 , Flt1 , Hras , Pik3ca , Prkab1 , Vegfb
Distal Hereditary Motor Neuronopathy, Type IIBHspb1
Distal Hereditary Motor Neuropathy, Type IHspb1
Drug-Induced EnteropathyNos3
Drug-Related Side Effects and Adverse ReactionsPtgs2
Duchenne muscular dystrophyCcl2 , Pla2g6
Ductal CarcinomaHif1a
ductal carcinoma in situFlt1 , Hif1a , Pak2 , Prkca , Ptgs2 , Ptk2 , Src , Vegfa
duodenal ulcerPla2g4a , Ptgs2 , Vegfa
dysembryoplastic neuroepithelial tumorBraf
dystonia 12Pla2g6
EdemaCasp9 , Map2k6 , Ptgs2
embryonal rhabdomyosarcomaPtpn11
end stage renal failureCcl2 , Itgb3 , Nos3 , Pgf , Ptgs2
endodermal sinus tumorCtnnb1
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerKras , Pik3cb , Pik3r1
endometrial carcinomaHras , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3r1
endometrial hyperplasiaKras , Ptk2
Endometrial NeoplasmsAkt2 , Bad , Braf , Ccl2 , Ctnna1 , Ctnnb1 , Flt1 , Grb2 , Kdr , Kras , Mapk3 , Nos3 , Pik3ca , Pik3cb , Pik3cd , Prkca , Ptgs2 , Ptk2 , Vegfa
Endometrioid CarcinomasAkt1 , Ctnnb1 , Kdr , Kras , Mapk1 , Mapk3 , Pik3r2
endometriosisCcl2 , Kdr , Kras , Nrp1 , Pla2g2a , Ptgs2 , Ptk2 , Vegfa
endometritisCasp9
endomyocardial fibrosisCcl2
EndotoxemiaCasp9 , Ccl2 , Itgb3 , Mapk14 , Nos3 , Pgf , Prkaa1 , Ptgs2
Endotoxin-Induced UveitisCcl2
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1 , Pgf
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOODPpp3ca
EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1Ppp3ca
erythema multiformeVegfa
esophageal carcinomaCtnnb1 , Hras , Kras , Pik3ca , Rhoa
Esophageal NeoplasmsCtnna1 , Kdr , Nos3 , Ptgs2
esophagitisPtgs2
esophagus adenocarcinomaPik3ca , Ptgs2
esophagus squamous cell carcinomaCtnnb1
essential hypertensionNos3
exfoliation syndromeCav1
Experimental ArthritisAkt1 , Cbl , Ccl2 , Cdc42 , Flt1 , Hif1a , Itgb3 , Nos3 , Nras , Pgf , Pik3cd , Ptgs2 , Vegfa
Experimental Autoimmune EncephalomyelitisCasp9 , Ccl2 , Flt1 , Kdr , Prkaa1 , Ptgs2 , Rhoa , Vegfa
Experimental Autoimmune MyocarditisCasp9 , Cav1 , Ccl2
Experimental Autoimmune NeuritisCav1 , Hif1a , Ptgs2 , Rhoa
Experimental Autoimmune OrchitisCcl2
Experimental Autoimmune UveitisCcl2
Experimental Autoimmune UveoretinitisCcl2
Experimental ColitisKdr , Mapk1 , Mapk3 , Vegfa
Experimental LeukemiaCbl , Nras
Experimental Liver CirrhosisCav1 , Ccl2 , Cdh5 , Fyn , Iqgap1 , Itgb3 , Mapk1 , Mapk3 , Nos3 , Pgf , Pla2g12a , Pla2g4a , Prkcb , Prkcd , Ptgs2 , Ptk2 , Rac2 , Rhoa , Vegfa
Experimental Liver NeoplasmsCtnnb1 , Hras , Kdr , Kras , Map2k1 , Mapk1 , Mapk3
Experimental MelanomaPxn
Experimental NeoplasmsBraf , Hif1a , Hras , Kras , Nras , Vegfa
Experimental SarcomaKras , Nras
extrahepatic cholestasisMapk1 , Mapk14 , Mapk3 , Nos3
extrinsic allergic alveolitisVegfa
Exudative Vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Eye NeoplasmsCcl2
Facial AsymmetryPik3ca
Failure to ThrivePtpn11
familial adenomatous polyposisAkt1 , Ptgs2
familial cold autoinflammatory syndrome 3Plcg2
familial erythrocytosis 3Egln1
familial hyperlipidemiaCcl2 , Nos3
familial hypertrophic cardiomyopathyCalm3 , Kras , Raf1 , Vcl
familial partial lipodystrophyAkt2 , Cav1
Familial Prostate CancerMap2k1
fatty liver diseaseCcl2 , Prkaa1 , Prkcd , Ptgs2
Febrile NeutropeniaCcl2
Female InfertilityHsp90ab1 , Mapk1 , Mapk3
Femur Head NecrosisHif1a
Fetal DiseasesPrkcb
Fetal Growth RetardationNos3 , Ptgs2 , Ptpn11
FeverHspb1 , Pla2g4a , Ptgs2
fibrillary astrocytomaKras
fibrosarcomaCdc42
FibrosisAkt1 , Ptgs2 , Rhoa , Sphk1
Fleck Retina, Familial BenignPla2g5
focal segmental glomerulosclerosisCasp9 , Hspb1 , Itgb3 , Ppp3ca , Ppp3cb
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras
Frontotemporal Lobar DegenerationHsp90aa1
fundus dystrophyCtnna1
fungal infectious diseaseCcl2
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsKras , Ptgs2
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Ptpn11 , Raf1 , Rhoa
gastric ulcerBad , Mapk1 , Mapk3 , Nos3 , Ptgs2 , Vegfa
gastritisCcl2 , Ptgs2
gastroesophageal reflux diseasePla2g2a , Ptgs2
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorBraf , Ctnna1 , Kras
genetic diseaseAkt2 , Akt3 , Braf , Calm2 , Cav1 , Cbl , Cdc42 , Ctnnb1 , Egln1 , Flt4 , Hras , Hspb1 , Kras , Map2k1 , Mapk1 , Nrp2 , Pik3ca , Pik3r1 , Pik3r2 , Pla2g6 , Plcg2 , Ppp3ca , Prkcg , Ptpn11 , Raf1 , Rhoa
Geographic AtrophyCcl2
Germ Cell and Embryonal NeoplasmsRhoa , Rock1
germinomaBraf
gestational diabetesCcl2
Giant Pigmented Hairy NevusHras , Nras
gingivitisVegfa
Glanzmann's thrombastheniaItgb3
glaucomaBad , Vegfa
glioblastoma multiformeAkt1 , Akt3 , Braf , Hif1a , Hras , Kras , Map2k2 , Map2k3 , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Ptgs2 , Ptk2 , Vegfa
gliosarcomaCcl2 , Ptgs2 , Vegfa
GliosisItgb3 , Mapk1 , Mapk3
glomerulonephritisCcl2 , Itgb3 , Mapk1 , Ptk2b , Vegfa
Glomus Tympanicum TumorVegfa
glucose intolerancePrkaa1 , Prkaa2
glycogen storage disease VHif1a
glycogen storage disease VIIHif1a
grade III astrocytomaKras
Graft Occlusion, VascularNos3
Graft vs Host DiseaseVegfa
Granuloma, Respiratory TractCcl2
granulomatosis with polyangiitisVtn
Granulomatous Interstitial NephritisCcl2
Granulomatous VasculitisCcl2
granulosa cell tumorCtnnb1 , Ptgs2 , Vegfa
Graves OphthalmopathyCcl2 , Ptgs2
Graves' diseaseItgb3 , Vegfa
Growth DisordersCbl , Pik3ca
growth hormone secreting pituitary adenomaPtgs2 , Ptpn11
Guillain-Barre syndromeCcl2
hairy cell leukemiaMap2k1
Hand-Foot SyndromeKdr
Hantavirus InfectionsItgb3
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca , Vegfa
head and neck squamous cell carcinomaAkt1 , Braf , Ctnnb1 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1 , Rhoa
Hearing Loss, Noise-InducedCcl2 , Hif1a
Hearing Loss, SuddenNos3
heart diseaseCasp9 , Mapk14 , Rac2 , Vegfa
heart valve diseaseCcl2 , Ptpn6
Helicobacter InfectionsPrkaa1
hemangioblastomaHif1a
hemarthrosisCcl2
Hematologic NeoplasmsCbl
HemimegalencephalyPik3ca
hemolytic-uremic syndromeCcl2
HemorrhageCav1 , Itgb3
hemorrhagic diseaseItgb3
hemorrhagic fever with renal syndromeItgb3
Henoch-Schoenlein purpuraCcl2
hepatic encephalopathyHif1a
Hepatic InsufficiencyMapk14 , Nos3
hepatoblastomaCtnnb1
Hepatoblastoma Caused By Somatic MutationCtnnb1
hepatocellular adenomaCtnnb1 , Hras , Kras , Ptpn11
hepatocellular carcinomaAkt1 , Akt2 , Braf , Casp9 , Ctnnb1 , Hif1a , Hras , Hspb1 , Iqgap1 , Kras , Nras , Pik3ca , Ptgs2 , Ptk2 , Rac1
HepatomegalyMapk14 , Nos3
hepatopulmonary syndromeNos3
Hereditary Desmoid DiseaseCtnnb1
hereditary lymphedemaFlt4 , Vegfc
hereditary lymphedema IFlt4
hereditary lymphedema IAFlt4
hereditary lymphedema IDVegfc
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesCtnna1 , Pik3ca
Hereditary PancreatitisCasp9
herpes simplexCcl2
herpes simplex virus keratitisCcl2 , Kdr
Hip FracturesItgb3
Hirschsprung Disease 1Kdr , Nrp2
Hot FlashesHif1a
human immunodeficiency virus infectious diseaseCcl2 , Cdc42 , Hsp90aa1 , Hsp90ab1 , Hspb1 , Pla2g2a , Ptgs2
Human InfluenzaCcl2 , Ptgs2
Huntington's diseaseCasp9 , Nos3 , Ppp3ca , Prkaa1 , Ptgs2
hydronephrosisPtgs2
hydrophthalmosFlt1 , Kdr
HyperalgesiaCcl2 , Hif1a , Map2k3 , Mapk1 , Mapk3 , Pla2g4a , Prkcb , Prkcg , Prkcz , Ptgs2 , Raf1
HypercholesterolemiaCasp9 , Vegfa
HyperemiaEgln1 , Nos3 , Ptgs2
hyperglycemiaCbl , Itgav , Nos3 , Pla2g4a , Prkcb , Prkcz , Ptgs2
hyperhomocysteinemiaCcl2
hyperinsulinismCcl2 , Nos3 , Prkcd
HyperoxaluriaCcl2
HyperoxiaNos3
HyperplasiaAkt1 , Cav1 , Hif1a , Hspb1 , Pik3ca , Ptgs2 , Vegfa
hypertensionAkt1 , Akt2 , Bad , Casp9 , Cav1 , Ccl2 , Egln1 , Hif1a , Itgav , Kdr , Kras , Nos3 , Pgf , Pik3r1 , Prkca , Prkcb , Prkcd , Ptgs2 , Ptk2 , Ptk2b , Ptprj , Rhoa , Src , Vegfa
Hypertension Resistant to Conventional TherapyNos3
Hypertension, Pregnancy-InducedNos3
HypertriglyceridemiaNos3
hypertrophic cardiomyopathyCav1 , Ctnnb1 , Hspb1 , Prkaca , Ptpn11 , Raf1 , Vcl
hypertrophic cardiomyopathy 15Vcl
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
Hypoglossal Nerve InjuriesPrkaca
hypoglycemiaAkt2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypothyroidismBad , Cav1 , Nos3
HypoxiaCcl2 , Nos3 , Pgf , Ptgs2
Hypoxia-Ischemia, BrainCasp9 , Ccl2 , Hif1a , Kdr , Vegfa
idiopathic pulmonary fibrosisHif1a , Ptgs2
IgA glomerulonephritisCcl2
immune system diseasePrkcb
Immunoblastic LymphadenopathyRhoa
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
imperforate anusCtnnb1
impotenceAkt1 , Bad , Kdr , Nos3 , Vegfa
in situ carcinomaAkt1 , Ctnnb1 , Ptgs2
InfarctionHif1a
InflammationAkt1 , Ccl2 , Pgf , Pla2g4a , Ptgs2 , Vegfa
inflammatory bowel diseasePlcg2 , Ptgs2 , Vegfa
influenzaCcl2
inherited metabolic disorderPla2g4a
Insulin ResistanceAkt2 , Bad , Ccl2 , Mapk3 , Nos3 , Pik3r1 , Pla2g1b , Prkaa1 , Prkaa2 , Prkcb , Prkcd , Prkcz , Ptk2b
intellectual disabilityCtnnb1 , Kras , Pgf , Prkcg
intermediate coronary syndromeAkt1
intermittent claudicationBad
interstitial lung diseaseCcl2
interstitial nephritisCcl2
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCtnnb1 , Map2k1 , Map2k2 , Pla2g2a , Prkca , Prkcd
intestinal obstructionPtgs2
intestinal perforationNos3
Intestinal PolypsPtgs2
Intestinal Reperfusion InjuryCasp9 , Ccl2 , Nos3
Intimal HyperplasiaNos3
intracranial aneurysmCcl2 , Nos3
Intracranial HemorrhagesHspb1 , Nos3
intracranial vasospasmCcl2
intrahepatic cholangiocarcinomaKras
invasive aspergillosisCcl2
invasive ductal carcinomaAkt1 , Hif1a , Ptgs2
invasive lobular carcinomaCtnna1 , Ctnnb1
Invasive Pulmonary AspergillosisCcl2 , Vegfa
inverted papillomaKdr , Vegfa
irritable bowel syndromeNos3
ischemiaAkt2 , Ccl2 , Flt1 , Itgav , Nos3 , Prkca , Ptk2 , Raf1
ischemic colitisVegfa
juvenile myelomonocytic leukemiaCbl , Kras , Nras , Ptpn11 , Rac2
juvenile rheumatoid arthritisKras , Mapk1 , Sh2d2a
Karak SyndromePla2g6
Kawasaki diseaseFlt1 , Vegfa
KeloidNedd4
keratoconusNfatc3 , Ppp3cc
kidney diseaseCasp9 , Ccl2 , Mapk1 , Ppp3ca , Ptgs2
kidney failureHif1a
Kidney NeoplasmsAkt1 , Braf , Flt1 , Kdr , Kras , Mapk1 , Mapk3 , Ptgs2 , Raf1
Kidney Reperfusion InjuryCcl2 , Egln1 , Egln3 , Hif1a , Nos3 , Src
Klinefelter's syndromeNras
Knee OsteoarthritisCtnnb1 , Hsp90aa1
Kuhnt-Junius degenerationCcl2 , Flt1 , Kdr , Nos3 , Vegfa
Langerhans-cell histiocytosisBraf
large cell carcinomaPrkca
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
LathyrismKdr
learning disabilityVegfa
Left Ventricular HypertrophyNfatc3 , Nfatc4 , Nos3 , Ppp3ca , Ppp3cb , Ppp3r1 , Prkca , Prkcb , Prkcd , Prkcz , Ptgs2 , Ptk2 , Ptk2b , Rac1 , Rhoa , Rock1
leiomyomaCav1 , Nos3 , Ptk2
leiomyosarcomaFlt1 , Ptgs2
LEOPARD syndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
Lethal Congenital Contracture Syndrome 5Dnm2
leukemiaBad , Nras , Prkcz , Ptpn11 , Sphk1
LeukocytosisKras , Nras
Leydig cell tumorFlt1
Limb IschemiaHif1a , Itgav , Nos3 , Vegfa
limited sclerodermaCav1 , Ccl2 , Kdr , Pgf
lipodystrophyCcl2
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
liver benign neoplasmBraf , Ctnnb1 , Egln3 , Hras , Kras , Map2k3 , Mapk14 , Raf1
liver cancerAkt1 , Ctnnb1 , Hras , Kras , Nras , Pik3ca
liver cirrhosisCasp9 , Ccl2 , Ctnnb1 , Flt1 , Nos3 , Pgf , Vegfa , Vtn
liver diseaseCcl2 , Nrp1 , Rac1
Liver FailureVegfa
Liver InjuryHspb1
Liver Reperfusion InjuryBad , Casp9 , Ccl2 , Nos3
long QT syndromeNos3 , Vcl
long QT syndrome 1Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
low tension glaucomaCav1
Lower Extremity Deep Vein ThrombosisCcl2
lung adenocarcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Rhoa
lung cancerBraf , Kras , Pik3ca , Rock1
lung diseaseCcl2 , Hif1a , Itgb3 , Nos3 , Ptgs2 , Vegfa
Lung InjuryCcl2
Lung NeoplasmsAkt1 , Braf , Cav1 , Ctnna1 , Ctnnb1 , Hras , Kras , Map2k3 , Mapk1 , Mapk14 , Mapk3 , Pik3ca , Ptgs2 , Raf1
Lung Reperfusion InjuryNos3
lung small cell carcinomaAkt1 , Pik3ca , Pik3r1 , Ptk2
lung squamous cell carcinomaAkt1 , Braf , Ctnnb1 , Hras , Kras , Pik3ca , Ptpn11
lupus nephritisCcl2
Lyme NeuroborreliosisCcl2
LymphangiectasisRaf1
lymphangioleiomyomatosisNos3 , Vegfd
lymphangiomaFlt4 , Kdr
Lymphatic MetastasisCasp9 , Cav1 , Ctnna1 , Ctnnb1 , Kdr , Nos3 , Pdpk1 , Pik3ca , Pik3cb , Ptgs2 , Rhoa , Vegfa , Vegfc , Vegfd
lymphedemaFlt4 , Pgf
lymphomaKras , Nras , Ptpn11 , Rac2
lymphopeniaCbl , Rac2
MacrocephalyAkt3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationBad , Ccl2 , Flt1 , Kdr , Vegfa
macular retinal edemaCcl2 , Flt1 , Kdr , Nos3 , Vegfa
major depressive disorderCalm2
malariaMapkapk3
male infertilityCbl , Nos3
Malformations of Cortical Development, Group IIPla2g4e
malignant gliomaAkt2 , Bad , Braf , Camkk2 , Cav1 , Hras , Kdr , Kras , Map2k1 , Mapk3 , Nos3 , Pik3ca , Pik3r3 , Prkca , Ptgs2 , Raf1 , Sphk1
malignant mesotheliomaCtnnb1 , Raf1
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Cav1 , Cdc42 , Ctnnb1 , Hif1a , Hras , Itgb3 , Kdr , Map2k3 , Mapk1 , Mapk3 , Pik3r1 , Ptgs2 , Ptk2 , Vegfa
Mandibular NeoplasmsBraf , Ctnnb1
mantle cell lymphomaCtnnb1 , Pik3cd
medulloblastomaCtnnb1 , Nras , Pik3ca
Megakaryoblastic Leukemia of Down SyndromeNras
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Braf , Cav1 , Cbl , Ccl2 , Ctnnb1 , Flt1 , Hras , Kdr , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3r1 , Ptgs2 , Ptk2b , Rac1 , Rac2 , Raf1 , Vcl , Vegfa , Vegfc
membranoproliferative glomerulonephritisCcl2
membranous glomerulonephritisRhoa
Memory DisordersHif1a , Sphk2 , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1
mental depressionPla2g2a , Ptgs2
Metabolic SyndromeCcl2 , Itgav , Nos3 , Pla2g4a , Pla2g6 , Ptgs2 , Vegfa
MetachondromatosisPtpn11
Micronuclei, Chromosome-DefectiveHif1a
Microsatellite InstabilityBraf
Microvascular Complications of Diabetes, Susceptibility to, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 7Vegfa
microvillus inclusion diseaseCdc42
middle cerebral artery infarctionBad , Casp9 , Ccl2 , Hif1a , Mapk1 , Mapk3 , Prkcg , Sphk2
migraineMap2k2 , Nos3
morbid obesityHif1a
mouth diseasePtgs2
Mouth NeoplasmsCcl2 , Hras , Hspb1 , Kras , Nras , Pik3ca , Ptgs2 , Ptk2
Multiple AbnormalitiesCav1 , Cdc42 , Ctnnb1 , Kras , Mapk1 , Pik3r2 , Pla2g6
Multiple Hamartoma SyndromePik3ca
multiple myelomaBraf , Cbl , Ccl2 , Hras , Hspb1 , Kras , Nras , Pik3ca , Ptpn11 , Vegfa
Multiple Organ FailureCcl2 , Mapk1
multiple sclerosisCav1 , Ccl2 , Hsp90ab1 , Rhoa , Sh2d2a , Vegfa
muscle tissue diseaseDnm2
muscular atrophyAkt1 , Ctnnb1 , Hsp90ab1 , Nedd4
muscular diseaseDnm2 , Prkcd
Mycobacterium Tuberculosis, Susceptibility To Infection ByCcl2 , Mapkapk3
mycosis fungoidesHif1a
myelodysplastic syndromeCtnna1 , Hras , Itgb3 , Kras , Nras , Sphk1
myeloid leukemiaVegfa
myeloid neoplasmCbl , Kras , Nras
myeloid sarcomaKras
myocardial infarctionAkt1 , Ccl2 , Egln1 , Egln3 , Flt1 , Hif1a , Itgb3 , Kdr , Mapk1 , Nos3 , Pgf , Ptgs2 , Vegfa , Vegfb
Myocardial IschemiaCcl2 , Hif1a , Itgav , Kdr , Map2k3 , Mapk14 , Nedd4 , Nos3 , Pgf , Pla2g2a , Ppp3r1 , Prkcd , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Cbl , Ccl2 , Egln1 , Hif1a , Map2k6 , Mapk1 , Mapk14 , Mapk3 , Nos3 , Prkcb , Prkcd , Ptgs2 , Rhoa , Vegfa
myocarditisCcl2 , Ptgs2
myofibrillar myopathyDnm2
myopathyDnm2
Nasal PolypsCcl2 , Kdr , Nos3 , Ptgs2 , Vegfa
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
NecrosisCdc42
Nematode InfectionsPik3r1
NeointimaFlt1 , Iqgap1 , Ptk2b
Neonatal Alloimmune ThrombocytopeniaItgb3
Neoplasm InvasivenessArf1 , Ccl2 , Ctnnb1 , Hif1a , Hras , Mapk1 , Mapk3 , Ptk2 , Rhoa , Src
Neoplasm MetastasisAkt2 , Braf , Cav1 , Ccl2 , Ctnnb1 , Flt1 , Hsp90aa1 , Itgb3 , Kdr , Kras , Mapk1 , Mapk3 , Nos3 , Pik3ca , Pik3r3 , Ptgs2 , Ptk2 , Pxn , Rac1 , Rhoa , Src , Vegfa
Neoplasm Recurrence, LocalPtgs2 , Vegfa
Neoplastic ProcessesHras
neovascular glaucomaVegfa
Neovascularization, PathologicKdr , Vegfa
nephritisCcl2 , Nos3 , Ptk2 , Ptk2b
nephroblastomaCtnnb1 , Flt1 , Hif1a , Ptgs2 , Vegfc
nephrogenic diabetes insipidusPrkca
Nephrogenic Fibrosing DermopathyCav1
Nephrosis, Puromycin AminonucleosidePak2
nephrotic syndromeNck1 , Nck2 , Ptgs2
Nerve DegenerationCtnnb1 , Mapk1 , Mapk3 , Vegfa
nervous system diseaseCasp9 , Nfatc2 , Ptgs2
neural tube defectCcl2
NeuralgiaKdr
neurilemmomaKdr
neuritisDnm2
neuroaxonal dystrophyPla2g6
neuroblastomaHras , Kras , Nras , Pik3ca , Ptpn11
Neurocutaneous MelanosisNras
neurodegeneration with brain iron accumulationPla2g6
neurodegeneration with brain iron accumulation 2APla2g6
neurodegeneration with brain iron accumulation 2BPla2g6
neurodegenerative diseasePla2g6
Neurodevelopmental DisordersCtnnb1 , Ptpn11
neuroendocrine tumorBraf
neurofibromaPtpn11
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
neurofibrosarcomaKdr , Nras , Vegfa
Neurogenic InflammationPtgs2
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
neuropathyDnm2
Neutrophil Immunodeficiency SyndromeRac2
NevusBraf , Pla2g6
Nevus, PigmentedNras
newborn respiratory distress syndromeVegfa
No-Reflow PhenomenonCdh5 , Ctnnb1
non-arteritic anterior ischemic optic neuropathyItgb3
non-Hodgkin lymphomaBraf , Map2k1 , Nras , Pik3ca , Rhoa
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cbl , Hif1a , Hras , Itgb3 , Kras , Map2k1 , Nras , Pdpk1 , Pik3ca , Prkcb , Ptgs2 , Pxn , Raf1 , Vegfa
nonalcoholic fatty liver diseasePrkaca , Prkca , Prkcd
Nonseminomatous Germ Cell TumorBraf
Noonan Like SyndromeCbl , Cdc42 , Ptpn11
Noonan syndromeBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1
Noonan syndrome 1Braf , Map2k1 , Nras , Ptpn11 , Raf1
Noonan syndrome 3Hras , Kras , Ptpn11 , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
NSAID-EnteropathyCasp9
obesityAkap1 , Akt1 , Akt2 , Bad , Cav1 , Ccl2 , Mapk1 , Mapk3 , Nos3 , Pgf , Pik3r1 , Prkcb , Prkcd , Ptgs2 , Rhoa
obsessive-compulsive disorderHras
Obstetric Labor, PrematureCcl2
obstructive jaundiceCcl2
obstructive sleep apneaCcl2 , Nos3 , Ptgs2
Occupational AsthmaPla2g4a , Prkca , Ptgs2
olfactory neuroblastomaHif1a
Ollier diseasePtpn11
open-angle glaucomaCav1 , Ptgs2
Optic Nerve InjuriesRhoa
oral mucosa leukoplakiaPtgs2
oral squamous cell carcinomaCcl2 , Plcg1
oral submucous fibrosisPtgs2
orchitisCcl2
osteoarthritisBad , Casp9 , Cav1 , Flt1 , Hif1a , Ptgs2
Osteoarthritis, ExperimentalFlt1 , Mapk3
osteochondrodysplasiaFlt1 , Kdr , Vegfa
OsteochondromaPtpn11
osteoporosisMapk14 , Vcl
osteosarcomaAkt1 , Vegfa
otitis mediaVegfa
Otitis Media with EffusionFlt1 , Kdr , Vegfa
ovarian cancerAkt1 , Ctnnb1 , Kras , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Camkk2 , Cav1 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hras , Kdr , Kras , Map2k1 , Map2k2 , Map2k6 , Mapk1 , Mapk3 , Nos3 , Pik3ca , Pik3r1 , Prkca , Ptgs2 , Ptk2 , Rhoa , Vegfa , Vegfc , Vegfd
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
overnutritionNos3
Oxygen-Induced RetinopathyCcl2 , Hif1a , Kdr , Vegfa
PainAkt1 , Ccl2 , Nos3 , Ptgs2
Painful NeuropathyCcl2
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaCtnnb1 , Hras , Kras , Map2k2 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Ctnnb1 , Hif1a , Hspb1 , Kdr , Kras , Nrp1 , Ptgs2 , Vegfb
pancreatic carcinomaKras
pancreatic ductal carcinomaKras , Ptgs2 , Vegfa
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisCcl2 , Hsp90ab1 , Ppp3ca , Ptgs2
Pancreatitis, Experimental, Acute Kras
papillary carcinomaVegfc
papillary renal cell carcinomaBraf , Ctnnb1 , Hras , Nras , Pik3ca
papillary thyroid carcinomaBraf , Ctnnb1
papillomaHras , Pla2g4a , Ptgs2
paraplegiaAkt1
Parasitic Liver DiseasesKras
Parathyroid NeoplasmsCtnnb1
Parkinson's diseaseAkt1 , Casp9 , Pla2g6
Parkinsonian DisordersBad , Casp9 , Prkcd , Ptgs2 , Src
Paroxysmal Ventricular FibrillationVcl
Pathologic ConstrictionItgb3
patterned macular dystrophyCtnna1 , Mapkapk3
patterned macular dystrophy 2Ctnna1
patterned macular dystrophy 3Mapkapk3
penile neoplasmHras , Kras , Pik3ca
peptic ulcer diseasePla2g4a
Perennial Allergic RhinitisCcl2 , Nos3
Peri-ImplantitisCcl2
periapical periodontitisCcl2
pericardial effusionPtgs2
perinatal necrotizing enterocolitisNos3
Periodontal AtrophyVegfa
Periodontal CystCcl2
periodontitisCcl2
Peripheral Nerve InjuriesCcl2 , Ptgs2
peripheral nervous system diseaseCasp9 , Dnm2
peripheral T-cell lymphomaFyn , Rhoa
Peritoneal NeoplasmsCtnnb1
persistent fetal circulation syndromeNos3
phencyclidine abuseCalm1 , Calm2
phobic disorderHras
Phospholipase A2, Group IVA, Deficiency ofPla2g4a
Phyllodes TumorCtnnb1 , Hif1a , Nos3
Pick's diseaseMap2k6
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
pilocytic astrocytomaKras
pilomatrixomaCtnnb1
Pituitary NeoplasmsPrkca
placental abruptionNos3
Plaque, AtheroscleroticItgb3
plasmacytomaBraf , Hras , Kras , Nras , Pik3ca , Ptpn11
platelet-type bleeding disorder 16Itgb3
pleomorphic xanthoastrocytomaBraf , Cav1 , Grb10 , Hspb1
pleural diseaseCcl2
pleurisyPla2g6 , Ptgs2
Pneumococcal PneumoniaMapk1 , Mapk3
pneumocystosisCcl2
pneumoniaCcl2 , Itgb3
polyarteritis nodosaVegfa
polycystic kidney diseaseHif1a , Nos3 , Pla2g4a , Plcg1 , Ptgs2
polycystic ovary syndromeAkt2 , Flt4 , Gab1 , Vegfa
polycythemiaEgln1
PolymicrogyriaAkt3
Polypoidal Choroidal VasculopathyVegfa
PolyuriaPrkca
portal hypertensionHsp90aa1 , Nos3 , Pik3r1 , Prkcd , Ptgs2 , Vegfa
post-traumatic stress disorderCasp9
Postmenopausal OsteoporosisHif1a , Ptk2b
Posttransfusion PurpuraItgb3
pre-eclampsiaFlt1 , Nos3 , Pgf , Vegfa
pre-malignant neoplasmAkt1 , Casp9 , Hras , Prkaa1 , Ptgs2 , Vegfa
Precocious PubertyPtgs2
precursor lymphoblastic lymphoma/leukemiaKras , Nos3 , Nras
precursor T-lymphoblastic lymphoma/leukemiaKras , Ptpn11
Pregnancy in DiabeticsVegfa
Premature BirthPgf , Ptgs2
Prenatal InjuriesRock1
PresbycusisHspb1
primary biliary cirrhosisCdh5 , Hif1a , Mapk14 , Nos3
primary cerebellar degenerationDnm2
primary immunodeficiency diseaseRac2
primary open angle glaucomaCav1 , Nos3
primary pigmented nodular adrenocortical diseasePrkaca
primary polycythemiaEgln1
primary pulmonary hypertensionCav1
Primary Pulmonary Hypertension, 3Cav1
Progressive Osseous HeteroplasiaCtnnb1
progressive supranuclear palsyMap2k6
prolactinomaPtgs2
proliferative diabetic retinopathyCcl2 , Flt1 , Vegfa
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Ctnnb1 , Grb2 , Hras , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkap1 , Akt2 , Akt3 , Ctnnb1 , Grb2 , Hif1a , Kdr , Kras , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Ptgs2 , Rac2 , Raf1
prostate carcinomaAkt2
prostate carcinoma in situFlt1 , Kras , Map2k6 , Ptgs2
prostatic hypertrophyBad , Kdr , Ptgs2
Prostatic NeoplasmsAkt1 , Bad , Braf , Camkk2 , Casp9 , Cav1 , Ctnna1 , Ctnnb1 , Flt1 , Hif1a , Hras , Hsp90ab1 , Itgb3 , Kdr , Kras , Map2k1 , Map2k6 , Mapk3 , Nedd4 , Nos3 , Nras , Nrp1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Ppp3ca , Prkca , Prkcz , Ptgs2 , Ptk2 , Ptk2b , Src , Vegfa
prostatitisPtgs2
proteinuriaNck1 , Nck2 , Pak2 , Ptgs2 , Rhoa , Vegfa , Vtn
Proteus syndromeAkt1
pseudoxanthoma elasticumVegfa
psoriasisCav1 , Flt1 , Hif1a , Kdr , Vegfa
PTEN hamartoma tumor syndromePik3ca
pterygiumKdr , Vegfa , Vegfc
Pulmonary ContusionCcl2
pulmonary edemaCcl2 , Nos3 , Vegfa
pulmonary embolismCcl2 , Nos3
pulmonary emphysemaCcl2 , Nos3 , Pgf , Ptgs2
pulmonary eosinophiliaNos3
pulmonary fibrosisBad , Cav1 , Ccl2 , Hsp90ab1 , Ptgs2
pulmonary hypertensionCav1 , Ccl2 , Hif1a , Mapk1 , Mapk3 , Nfatc2 , Nos3 , Pgf , Ptgs2 , Ptk2 , Rhoa , Vegfb
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3 , Nos3
pulmonary tuberculosisCcl2
pulmonary valve stenosisBraf , Hras
pyelonephritisPgf
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalCasp9 , Hif1a , Mapk1 , Mapk3 , Ptgs2
Radiation PneumonitisNos3 , Vtn
RASopathiesBraf , Cbl , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1
rectal neoplasmNras , Pik3ca , Pik3cb
RecurrenceFlt1 , Hras , Kras , Vegfc
renal carcinomaNras , Pik3ca
renal cell carcinomaAkt1 , Akt3 , Bad , Cav1 , Ctnna1 , Ctnnb1 , Egln1 , Egln2 , Egln3 , Flt1 , Hif1a , Hspb1 , Kdr , Kras , Map2k1 , Mapk1 , Nras , Pgf , Pik3ca , Pik3r1 , Ptgs2 , Vegfa , Vegfc
renal fibrosisKras , Mapk1
renal hypertensionNos3
renovascular hypertensionNos3
Reperfusion InjuryAkt1 , Bad , Casp9 , Cav1 , Ccl2 , Cdc42 , Hif1a , Hspb1 , Itgb3 , Kdr , Nos3 , Pik3r1 , Pla2g2a , Pla2g4a , Ppp3ca , Ppp3cb , Prkca , Ptgs2 , Ptk2 , Ptk2b , Src , Vegfc , Vegfd
respiratory allergyNos3 , Ptpn6
restrictive cardiomyopathyMap2k3 , Map2k6 , Mapk14 , Prkcd
Retina Reperfusion InjuryBad , Ccl2 , Hspb1 , Nos3 , Vegfa
retinal degenerationCcl2 , Nos3
retinal detachmentCasp9 , Ccl2
retinal diseaseMap2k3 , Vegfa
retinal ischemiaHif1a , Vegfa
Retinal NeovascularizationHif1a , Itgav , Vegfa , Vegfb
retinal telangiectasiaKdr , Vegfa
retinal vein occlusionNrp1 , Vegfa , Vegfb
retinitisCcl2
retinitis pigmentosaPrkcg , Vegfa
retinopathy of prematurityFlt1 , Kdr , Nos3 , Vegfa
retrograde amnesiaPtgs2
rhabdomyosarcomaVegfa
rheumatoid arthritisCcl2 , Hif1a , Hsp90aa1 , Hspb1 , Pgf , Ptgs2 , Ptk2 , Vegfa
rhinitisCdc42 , Vegfa
Right Ventricular HypertrophyAkt1 , Nfatc3 , Nfatc4 , Nos3 , Ppp3ca , Ppp3cb , Prkca , Prkcd , Ptk2
sarcoidosisPtgs2
sarcomaCcl2 , Hspb1 , Kdr , Pik3ca
SarcopeniaCav1
schizophreniaAkt1 , Ccl2 , Fyn , Kdr , Mapk3 , Pak2 , Pik3cb , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Ptgs2
sciatic neuropathyCav1 , Ccl2
sclerosing cholangitisHif1a
scoliosisPtpn11
scrapieCasp9
Seasonal Allergic RhinitisKdr , Vegfa
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
secondary hyperparathyroidismPtgs2
seminomaHras , Kras , Vegfa
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossPrkcb
SepsisBad , Casp9 , Ccl2 , Flt1 , Fyn , Mapk1 , Mapk3 , Nos3 , Pgf , Pla2g2a , Pla2g4a
Septic PeritonitisPik3r1
severe combined immunodeficiencyRac2
Sezary's diseaseBraf , Mapk1 , Plcg1
ShockMapk1 , Mapk3
Shock, HemorrhagicBad , Mapk1 , Nos3
SHORT SyndromePik3r1
sickle cell anemiaNos3 , Pgf
silicosisCcl2 , Prkcb
skin benign neoplasmHras
skin diseaseFyn , Ptgs2
skin melanomaAkt1 , Braf , Ctnnb1 , Hif1a , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Rac1 , Raf1
Skin NeoplasmsAkt1 , Ctnnb1 , Flt1 , Hif1a , Hras , Ptgs2 , Ptk2b , Vegfa
skin squamous cell carcinomaFyn
Sleep DeprivationPtgs2
Small-For-Size SyndromeBad , Vegfa
Smith-Magenis syndromeAkap1 , Ccl2 , Grb2 , Hgs , Itgb3 , Map2k2 , Map2k3 , Map2k6 , Prkca , Sphk1 , Vtn
spermatocytomaHras
spina bifidaCcl2
Spinal Cord CompressionCcl2 , Nos3
Spinal Cord InjuriesAkt1 , Casp9 , Cav1 , Cdc42 , Flt1 , Hif1a , Hsp90ab1 , Hspb1 , Kdr , Nos3 , Pla2g2a , Pla2g6 , Ptgs2 , Vegfa
Spinal Cord Reperfusion InjuryBad
spinocerebellar ataxia type 14Prkcg
Spinocerebellar AtaxiasPrkcg
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Hras , Pik3ca
squamous cell carcinomaAkt1 , Cav1 , Ccl2 , Hras , Hspb1 , Kdr , Kras , Mapk1 , Mapk3 , Pik3ca , Ptgs2 , Ptk2 , Ptpn11 , Vegfa
status epilepticusCcl2 , Hspb1 , Pgf , Prkcb , Ptgs2 , Ptk2b , Src , Vegfa
Stevens-Johnson syndromeCav1 , Ctnnb1 , Nedd4
stomach cancerKras , Pik3ca
stomach carcinomaKras
Stomach NeoplasmsCav1 , Ctnnb1 , Fyn , Hras , Hspb1 , Kras , Mapk1 , Mapk3 , Nos3 , Nras , Pik3ca , Prkaa1 , Prkab1 , Prkcb , Ptgs2 , Rhoa
StrokeAkt1 , Ccl2 , Ctnnb1 , Itgav , Itgb3 , Kdr , Nos3 , Pgf , Pik3ca , Prkaa2 , Prkcd , Ptgs2 , Src , Vegfa
Subarachnoid HemorrhageCasp9 , Hif1a , Nos3 , Ptgs2
substance-induced psychosisAkt1
Sudden Death, CardiacItgb3
sudden infant death syndromeVegfa
systemic lupus erythematosusCcl2 , Pgf , Ptgs2
systemic sclerodermaCav1 , Ccl2 , Flt4 , Kdr , Ptgs2 , Vegfa
T-Cell LymphomaAkt1 , Rhoa
Takenouchi-Kosaki SyndromeCdc42
telangiectasisNos3
temporal arteritisCcl2
temporal lobe epilepsyCdc42 , Fyn , Kdr , Pgf , Vegfa
Temporomandibular Joint DisordersHif1a
teratomaCtnnb1
testicular diseasePpp3ca
Testis Reperfusion InjuryCasp9 , Hif1a , Mapk1 , Mapk3 , Nos3
tetralogy of FallotFlt4 , Ptpn11
third ventricle chordoid gliomaPrkca
thrombocytopeniaCcl2 , Itgb3
THROMBOCYTOPENIA 6Src
Thrombocytopenic PurpuraItgb3
ThromboembolismNos3
thrombosisPik3cb , Ptgs2 , Vtn
Thrombotic MicroangiopathiesItgb3 , Nos3 , Vegfa
thymomaHras
thyroid cancerMapk1
thyroid gland diseaseCcl2
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccl2 , Hif1a , Hras , Kras , Map2k3 , Nras , Pik3ca , Ptgs2
Tibial FracturesPgf
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsHras , Hspb1 , Ptgs2 , Vegfa , Vegfc
tongue squamous cell carcinomaKdr
toxic encephalopathyEgln1 , Prkcd
transient cerebral ischemiaBad , Casp9 , Cav1 , Cbl , Ccl2 , Flt1 , Hif1a , Hspb1 , Itgb3 , Nos3
transitional cell carcinomaAkt1 , Braf , Cav1 , Ctnna1 , Ctnnb1 , Hras , Kdr , Kras , Map2k1 , Mapk1 , Nras , Pik3ca , Pla2g4a , Ptgs2
Transplant RejectionCcl2 , Kdr , Nos3
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3 , Prkcg
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusCasp9 , Cbl , Ccl2 , Nos3
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Braf , Calm1 , Casp9 , Ccl2 , Flt1 , Hif1a , Kdr , Mapk1 , Mapk3 , Nos3 , Pik3cb , Pik3r1 , Prkaa1 , Prkaa2 , Prkcb , Prkcz , Ptgs2 , Sphk1 , Src , Vegfa
UlcerHif1a , Itgb3
ulcerative colitisKdr , Sphk1 , Vegfa
uremiaFlt1 , Kdr , Nos3 , Ptk2
ureteral obstructionAkt1 , Casp9 , Ccl2 , Mapk1 , Mapk3 , Nos3 , Pak2
urethral obstructionMapk1
urinary bladder cancerAkt1 , Casp9 , Cav1 , Ctnna1 , Ctnnb1 , Hras , Kdr , Kras , Nedd4 , Nos3 , Prkca , Ptgs2 , Rhoa , Src , Vegfa , Vegfc , Vegfd
Urinary Bladder NeoplasmHras , Kras
Urinary IncontinenceMapk1
Urologic NeoplasmsHif1a , Ptgs2 , Rhoa , Vegfa
uterine carcinosarcomaHras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Ctnna1 , Ctnnb1 , Flt1 , Hras , Kdr , Kras , Map2k3 , Map2k6 , Mapk1 , Nras , Pik3ca , Ptgs2 , Ptk2 , Vegfa
Uterine NeoplasmsBraf , Ctnnb1 , Flt1 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Rac1
uveal melanomaKdr , Vegfa
uveitisCcl2
varicoceleCasp9 , Hif1a
Vascular CalcificationCtnnb1
vascular dementiaFlt1
Vascular MalformationsPik3ca
Vascular System InjuriesIqgap1
vasculitisCbl , Nos3
Vasculitis of the SkinCcl2
Vaso-occlusive CrisisNos3
velocardiofacial syndromeMapk1
Venous ThrombosisCcl2 , Itgb3 , Kdr , Nos3
Ventilator-Induced Lung InjuryAkt1 , Ptgs2
Ventricular Dysfunction, LeftRac1
Ventricular Dysfunction, RightNos3
Ventricular Fibrillation, Paroxysmal Familial, 1Vcl
Ventricular Premature ComplexesNos3
ventricular septal defectBraf , Pgf
Ventricular TachycardiaNos3 , Ppp3ca , Raf1
vestibular diseaseNos3
viral pneumoniaCcl2
visual epilepsyBad , Nrp2 , Pik3ca , Prkcd , Ptgs2 , Vtn
vitiligoPik3r1
Vulvar NeoplasmsNos3
Wallerian DegenerationPgf , Pla2g4a , Pla2g6
Weight GainCalm1 , Cav1 , Iqgap1 , Pik3ca
Weissenbacher-Zweymuller syndromeMapk1
Werner syndromeHif1a
Wernicke encephalopathyPtgs2
Williams-Beuren syndromeSrc
Wilson diseasePpp3ca , Ppp3cb
withdrawal disorderMapk1 , Mapk3
Wolff-Parkinson-White syndromeVcl
Wounds and InjuriesVegfa
Wounds, PenetratingPgf
Pathway Annotations Associated with Genes in the vascular endothelial growth factor signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItgb3
acebutolol pharmacodynamics pathwayCalm1 , Prkaca
acetylsalicylic acid pharmacodynamics pathwayPla2g4b , Ptgs2
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Camkk2 , Prkaa1 , Prkaa2 , Prkab1 , Prkag1
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Hras , Map2k2 , Map2k6 , Mapk1 , Mapk11 , Pdpk1 , Pik3ca , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1 , Prkaca
aldosterone signaling pathwayHsp90aa1 , Hsp90ab1 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
alpha-linoleic acid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 , Pla2g4a , Pla2g4b , Pla2g4e , Pla2g4f , Pla2g5 , Pla2g6
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered Reelin signaling pathwayFyn , Src
altered vascular endothelial growth factor signaling pathwayFlt4
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionKdr , Vegfa
altered vascular endothelial growth factor signaling pathway involving the main playersFlt4 , Kdr , Vegfa
altered Wnt signaling, canonical pathwayCtnnb1
Alzheimer's disease pathwayBad , Calm1 , Calm2 , Calm3 , Casp9 , Chp1 , Chp2 , Mapk1 , Mapk3 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588
amiodarone pharmacodynamics pathwayCalm1 , Prkaca
amlodipine pharmacodynamics pathwayCalm1 , Prkaca
amyotrophic lateral sclerosis pathwayBad , Casp9 , Chp1 , Chp2 , Map2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Rac1 , RGD1564956 , RGD1565588
androgen signaling pathwayHsp90aa1 , Hsp90ab1
angiotensin II signaling pathwayCcl2 , Pdpk1 , Pla2g6 , Prkcz
angiotensin II signaling pathway via AT2 receptorPtpn6
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1
antipyrine drug pathwayPla2g4b , Ptgs2
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chp1 , Chp2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , RGD1564956 , RGD1565588
arachidonic acid metabolic pathwayPla2g10 , Pla2g12a , Pla2g12b , Pla2g1b , Pla2g2a , Pla2g2c , Pla2g2d , Pla2g2f , Pla2g3 ,