TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY (PW:0000233)

View Ontology Report

Description

Tumor necrosis factor (Tnf or Tnfa) signaling pathway plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis through the activation of several downstream signaling cascades. Tumor necrosis factor and its receptors Tnfrsf1a and Tnfrsf1b (Tnfr1 and Tnfr2) belong to the tumor necrosis superfamilies of ligands and receptors of which 19 and 29 members have been so far identified in humans, respectively. Tnf signaling occurs primarily via Tnfrsf1a receptor (Tnf-R1), ubiquit

Pathway Diagram:

Elsevier Inc. Ripk1 K63-ubiquitin M1-Ubiquitin Tradd M1-ubiquitination K63-ubiquitin ---- Tab3 K63-ubiquitin ---- Tab2 Cyld Casp8 ---- Fadd Fadd Casp8 --+> extrinsic apoptotic pathway extrinsic apoptotic pathway TRAF5 Traf2 Birc2 ---> Ripk1 Birc3 ---- Traf2 Birc3 Ripk1 --+> Map3k7 Birc3 ---- LUBAC complex Bag4 Fadd ---- Tradd Tnfrsf1a ---- Tradd Tnfrsf1a Adam17 ---> Tnf Tnf ---- Tnfrsf1a Tnf Bag4 ---| Tnfrsf1a Tradd ---- TRAF5 Tradd ---- Traf2 Ripk1 ---- Tradd Birc2 Birc2 ---- LUBAC complex LUBAC complex ---- TRAF5 LUBAC complex ---- Tradd LUBAC complex ---- Traf2 A20 ubiquitin-editing complex ---| K63-polyubiquitination Adam17 nuclear factor kappa B signaling pathway Map3k7 --+> nuclear factor kappa B signaling pathway p38 MAPK signaling pathway Map3k7 Map3k7 ---- Tab1 LUBAC complex ---> Ripk1 Birc3 ---> Ripk1 Map3k7 --+> p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway Map3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway Tab1 Tab2 Tab3 Casp8 Map3k7 ---- Tab3 Map3k7 ---- Tab2 A20 ubiquitin-editing complex LUBAC complex K63-polyubiquitination Cyld ---| Map3k7 Cyld ---| K63-polyubiquitination
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Genes in Pathway:

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tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2292150
RGD:6484113
G Bag4 BCL2-associated athanogene 4 JBrowse link 16 71,057,709 71,075,874 RGD:2292150
RGD:6484113
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6484113
RGD:7800730
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6484113
RGD:7800730
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6484113
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:2292150
RGD:6484113
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6484113
RGD:7800735
RGD:7800734
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:2292150
RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2292150
RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2292150
RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:7800734
RGD:7800735
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:6484113
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6484113
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6484113
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:6484113
RGD:5490225
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 JBrowse link 1 221,710,622 221,726,274 RGD:6484113
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 JBrowse link 6 3,276,732 3,444,519 RGD:6484113
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:6484113
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 JBrowse link 6 92,136,242 92,229,578 RGD:6484113
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nrk Nik related kinase JBrowse link X
X
109,940,439
110,065,199
110,036,361
110,089,124
RGD:6484113
G Nsmaf neutral sphingomyelinase activation associated factor JBrowse link 5 19,499,111 19,560,308 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:6484113
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:7800730
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:6484113
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:2292150
RGD:7800730
RGD:6484113
G Rnf11 ring finger protein 11 JBrowse link 5 129,296,271 129,298,513 RGD:7800734
RGD:7800735
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:7800730
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:7800730
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:6484113
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:6484113
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
RGD:5490225
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
RGD:5490225
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490225
G Tax1bp1 Tax1 binding protein 1 JBrowse link 4 82,776,720 82,832,586 RGD:7800734
RGD:7800735
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580210
RGD:6484113
RGD:2292150
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:7800734
RGD:7800735
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:2292150
RGD:6484113
RGD:5130945
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:2292150
RGD:6484113
G Tnik TRAF2 and NCK interacting kinase JBrowse link 2 113,984,599 114,391,805 RGD:6484113
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:2292150
RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2292150
RGD:7800730
RGD:6484113
RGD:5130945
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexA20 ubiquitin-editing complexdeubiquitinase, K48-ubiquitin
ComplexLUBAC complexM1-ubiquitin

Pathway Gene Annotations

Disease Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
abdominal aortic aneurysmCav1
abdominal obesity-metabolic syndromePrkci
acneTnf , Tnfrsf1a , Tnfrsf1b
acoustic neuromaCav1
acquired immunodeficiency syndromeTnf , Tnfrsf1a , Tnfrsf1b
Acute Coronary SyndromeTnf
acute kidney failureNfkb1 , Tnf , Tnfrsf1a , Tnfrsf1b
Acute Liver FailureTnf
Acute Lung InjuryCav1 , Fadd , Tnf , Txn1
acute myeloid leukemiaFadd
adenocarcinomaCasp8 , Nfkb1 , Tnf
adult respiratory distress syndromeTnf , Tnfrsf1a , Tnfrsf1b
AlbuminuriaTnf
alcoholic hepatitisTnf
alcoholic liver cirrhosisRela , Tnf
Alcoholic Liver DiseasesCav1
allergic bronchopulmonary aspergillosisTnf , Tnfrsf1a
allergic contact dermatitisCasp8 , Tnf
allergic hypersensitivity diseaseTnf , Tnfrsf1a , Tnfrsf1b
Alveolar Bone LossTnf
Alzheimer's diseaseCav1 , Ikbkb , Tnf
amphetamine abuseRela
amyloidosisTnf , Tnfrsf1a
amyotrophic lateral sclerosisMap3k5 , Sqstm1 , Tnf
amyotrophic lateral sclerosis type 1Tnf
anemiaTnf , Tnfrsf1a
Anemia, RefractoryTnf
Angina, StableTnf
angiomyolipomaStat1
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsTnf
ankylosing spondylitisTnfrsf1b
AnorexiaTnf , Tnfrsf1a
anterior uveitisTnf
anthracosisTnf
anti-basement membrane glomerulonephritisTnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf , Tnfrsf1a , Tnfrsf1b
anxiety disorderTnf
aplastic anemiaTnf
Arsenic PoisoningTnf , Tnik
Arterial InjuryMap3k5
Arterial Occlusive DiseasesTxn1
arteriosclerosisRela , Tnfrsf1a
arteriovenous malformations of the brainMap4k4
asbestosisTnf
aspiration pneumoniaTnf
asthmaChuk , Tnf , Tnfrsf1a
Asthma, OccupationalTnf
astrocytomaMap2k3
atherosclerosisCav1 , Tnf
atopic dermatitisCasp8 , Sharpin , Tnf
atrial fibrillationCav1 , Tnf
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autistic disorderTnf , Tnfrsf1b
Autoimmune DiseasesCasp8 , Tnfaip3 , Tnfrsf1a
autoimmune lymphoproliferative syndromeCasp8
autoimmune lymphoproliferative syndrome type 2BCasp8
autoimmune thyroiditisTnf
autosomal dominant familial periodic feverTnfrsf1a
autosomal recessive pseudohypoaldosteronism type 1Tnfrsf1a
bacterial infectious diseaseCasp8
bacterial pneumoniaChuk , Tnf , Tnfrsf1a , Tnfrsf1b
Barrett's esophagusRela
Behcet's diseaseIkbkg , Tnf , Tnfrsf1a
berylliosisTnf
beta thalassemiaTnf
bilirubin metabolic disorderTnf
BlisterAdam17
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
Bone FracturesTnfrsf1b
brain edemaTnf
Brain InjuriesCasp8 , Rela , Stat1 , Tnf , Tnfrsf1a
brain ischemiaCav1 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Brain NeoplasmsRela
breast cancerCasp8 , Cav1 , Nfkb1 , Stat1
Breast NeoplasmsBirc2 , Casp8 , Cav1 , Ikbkb , Map2k3 , Map2k7 , Map3k1 , Prkci , Rela , Stat1 , Tnf
Bronchial HyperreactivityTnf
Bronchial SpasmTnfrsf1b
bronchiectasisTnf
Bronchiectasis with or without Elevated Sweat Chloride 1Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 2Tnfrsf1a
Bronchiectasis with or without Elevated Sweat Chloride 3Tnfrsf1a
Bronchopulmonary DysplasiaTnf , Txn1
Brooke-Spiegler syndromeCyld
BurnsTnf
CachexiaTnf , Tnfrsf1a
Candidiasis, Familial, 6Stat1
Carbon Tetrachloride PoisoningFadd
cardiac arrestTnf
CardiomegalyCav1 , Prkcz , Rbck1 , Rela , Tnf
cardiomyopathyMap3k5 , Tnf , Txn1
Cardiomyopathy, Hypertrophic, FamilialMadd
Cardiovirus InfectionsTnf
Carotid Artery InjuriesMap3k5
Cell Transformation, NeoplasticNfkb1 , Rela , Tnfaip3
Cerebral HemorrhageCasp8 , Nfkb1 , Rela , Sqstm1
cerebral infarctionMap3k5 , Tnf
cerebral malariaTnfrsf1b
cervix uteri carcinoma in situRela
Chemical and Drug Induced Liver InjuryCasp8 , Fadd , Map3k5 , Tnf
Childhood SchizophreniaRela
chlamydiaTnf
cholestasisRela , Tnf
cholesteatoma of middle earRela , Tnf
chorioamnionitisTnf
Choroidal NeovascularizationIkbkb
Chronic Allograft DysfunctionTnf
Chronic Cerebral HypoperfusionMap3k5
Chronic Lymphocytic Leukemia, B-CellTnf
chronic mucocutaneous candidiasisStat1
chronic obstructive pulmonary diseaseTnf , Tnfrsf1a , Tnfrsf1b
cicatricial pemphigoidTnf
cleft palateChuk
cocoon syndromeChuk
Cognition DisordersMap3k5
colitisAdam17 , Chuk , Ikbkb , Rela , Tnf
Colonic NeoplasmsIkbkb , Map2k3 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
colorectal adenomaTnfrsf1a
Colorectal NeoplasmsCasp8 , Tnf
common variable immunodeficiencyNfkb1
Common Variable Immunodeficiency 12Nfkb1
congenital diaphragmatic herniaTnf
congenital generalized lipodystrophy type 3Cav1
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Limb DeformitiesChuk
congestive heart failureMap2k7 , Map3k5 , Tnf , Tnfrsf1a , Tnfrsf1b
contact dermatitisCasp8 , Txn1
Cor pulmonaleTnf
corneal ulcerTnf
coronary artery diseaseTnf , Tnfrsf1a
coronary restenosisTnf
CoughTnf
Coxsackievirus InfectionsTnf
Craniofacial AbnormalitiesFadd
Crohn's diseaseTnf , Tnfrsf1a , Tnfrsf1b
cryoglobulinemiaTnf
cryptogenic organizing pneumoniaTnfrsf1a , Tnfrsf1b
cryptorchidismRela
cutaneous leishmaniasisTnf
cutaneous T cell lymphomaTnfaip3
cystic fibrosisTnf , Tnfrsf1a
cystitisRela , Tnf
Cytomegalovirus InfectionsStat1 , Tnf
cytomegalovirus retinitisTnf , Tnfrsf1a
demyelinating diseaseTnf
Dermal FibrosisCav1
dermatitisIkbkb , Sharpin , Tnf
dermatitis herpetiformisTnf
dermatomyositisTnf
diabetes mellitusCav1 , Map3k5
diabetic angiopathyRela , Tnf
Diabetic CardiomyopathiesTnf
Diabetic NephropathiesRela , Tnf , Tnfrsf1a , Tnfrsf1b
diabetic neuropathyCav1 , Tnf
diabetic retinopathyTnf
dilated cardiomyopathyTnf , Txn1
dilated cardiomyopathy 1HTnf
disease by infectious agentTnf
Disease ProgressionStat1
disseminated intravascular coagulationTnf
drug allergyTnf
Drug-Induced DyskinesiaRela
Drug-Related Side Effects and Adverse ReactionsTxn1
dry eye syndromeTnf
ductal carcinoma in situRela
Eales DiseaseTnf
EdemaCasp8 , Tnf
EmphysemaTnf
encephalitisRela , Tnf
encephalomyelitisTnf
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg
End Stage Liver DiseaseTnfrsf1a
end stage renal failureNfkb1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Endometrial NeoplasmsTnfrsf1a , Tnfrsf1b
endometriosisTnf , Tnfrsf1b
endophthalmitisTnf
EndotoxemiaTnf
Enterovirus InfectionsTnfrsf1a
EosinophiliaSharpin
EpendymomaMap4k3
epilepsyRela , Tnf
Erythema NodosumTnf
Esophageal NeoplasmsCasp8 , Map3k3
esophagitisTnf
exfoliation syndromeCav1
Experimental ArthritisIkbkb , Ikbkg , Map3k5 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b
Experimental Autoimmune EncephalomyelitisAdam17 , Casp8 , Stat1 , Tnf
Experimental Autoimmune MyocarditisCav1
Experimental Autoimmune NeuritisCav1 , Tnf
Experimental Autoimmune UveoretinitisTnfrsf1a
Experimental ColitisTnf , Tnfrsf1a
Experimental Diabetes MellitusCasp8 , Cav1 , Ikbkb , Map2k3 , Map3k5 , Prkci , Rela , Smpd1 , Stat1 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1
Experimental Liver CirrhosisAdam17 , Birc3 , Cav1 , Rela , Tnf
Experimental NeoplasmsRela , Tnf
extrahepatic cholestasisMap3k7 , Rela , Tnf
extrinsic allergic alveolitisTnf , Tnfrsf1a , Tnfrsf1b
eye diseaseTnf
Familial Autoinflammatory Syndrome, Behcet-likeTnfaip3
familial Mediterranean feverTnfrsf1a
Familial Paget's Disease of BoneSqstm1
familial partial lipodystrophyCav1
Fanconi anemiaTnf
farmer's lungTnf
FatigueTnfrsf1b
fatty liver diseaseBirc3 , Ikbkg , Nfkb1 , Rela , Tnf , Txn1
Fetal DeathTnfrsf1b
Fetal DiseasesChuk
FeverTnf , Tnfrsf1a
Fibromatosis, AggressiveTnf
fibrosarcomaTnfrsf1a
FibrosisMap2k7 , Tnf
focal segmental glomerulosclerosisTnf , Tnfrsf1a , Tnfrsf1b
follicular lymphomaTnfaip3
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
FTDALS1Sqstm1
FTDALS3Sqstm1
Fungal Lung DiseasesTnf
gastric ulcerTnf
gastritisTnf
Gaucher's diseaseTnf
genetic diseaseCav1 , Ikbkg , Map3k1 , Stat1 , Tnfrsf1a
glaucomaTnf , Txn1
glioblastoma multiformeMap2k3
glomerulonephritisTnf , Tnfrsf1a , Tnfrsf1b
glomerulosclerosisTnfrsf1b
glucosephosphate dehydrogenase deficiencyIkbkg
glycogen storage disease IVRbck1
Graves OphthalmopathyTnf
Graves' diseaseTnf
head and neck squamous cell carcinomaCasp8
HeadacheTnfrsf1b
Hearing LossStat1 , Tnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SuddenTnf
Heat StrokeNfkb1 , Rela , Tnf
hemochromatosisTnf
hemolytic-uremic syndromeTnf
HemorrhageCav1
hepatic encephalopathyTnf
Hepatitis C, ChronicTnfrsf1a
hepatocellular carcinomaCasp8 , Cyld , Stat1 , Tnf
hepatorenal syndromeTnf
Hereditary Autoinflammatory DiseasesTnfaip3
hereditary hemorrhagic telangiectasiaTnf
hereditary spastic paraplegiaMap4k5
hereditary spastic paraplegia 3AMap4k5
Hernias, Diaphragmatic, CongenitalTnf
herpes simplex virus keratitisTnf
herpes zosterTnf
hidradenitis suppurativaTnf
HIV Wasting SyndromeTnf
human immunodeficiency virus infectious diseaseBirc2 , Birc3 , Tnf
Human InfluenzaStat1 , Tnf , Tnfrsf1a
Huntington's diseaseCasp8 , Map3k5 , Nfkb1
HyperalgesiaMap2k3 , Prkcz , Tnf , Tnfrsf1a , Tnfrsf1b
Hyperbilirubinemia, NeonatalIkbkb
hypercalcemiaTnf
hyperglycemiaCasp8 , Prkcz
hyperhomocysteinemiaTnf
HyperoxaluriaNfkb1
HyperoxiaFadd , Tnf , Tnfrsf1a
HyperplasiaCav1 , Ikbkb
hypertensionCav1 , Fadd , Ikbkb , Rela , Rffl , Sqstm1 , Tnf
hypertrophic cardiomyopathyCav1 , Madd
hypertrophic cardiomyopathy 4Madd
Hypertrophy, Left VentricularPrkcz , Rela
HypoalbuminemiaTnfrsf1b
hypochromic microcytic anemiaTnf
hypoglycemiaTnf
hypohidrotic ectodermal dysplasiaIkbkg
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
HypotensionTnf
HypothermiaTnf
hypothyroidismCav1
Hypoxia-Ischemia, BrainMap3k5
idiopathic pulmonary fibrosisTnf
IgA glomerulonephritisTnf , Tnfrsf1a , Tnfrsf1b
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
impotenceTnf
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
InflammationChuk , Tnf , Tnfaip3 , Tnfrsf1b
inflammatory bowel diseaseIkbkb , Tnf
Insulin ResistanceIkbkb , Prkcz , Rela , Tnf , Tnfrsf1a
intermediate coronary syndromeTxn1
intermediate uveitisTnf
interstitial cystitisTnf
Intervertebral Disc DisplacementTnf , Tnfrsf1b
intracranial aneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
iron deficiency anemiaTnf
irritable bowel syndromeIkbkg
ischemiaTnfrsf1a
juvenile rheumatoid arthritisTnik
Kawasaki diseaseTnf
keratoconjunctivitis siccaTnf
kidney diseaseSmpd1 , Tnf , Tnfrsf1a
kidney failureTnfrsf1b
Kidney Reperfusion InjuryIkbkb , Map3k5 , Tnf , Tnfrsf1a
labyrinthitisTnf
learning disabilityIkbkg
Legionnaires' diseaseTnfrsf1a , Tnfrsf1b
leiomyomaCav1
leishmaniasisTnf
leprosyTnf
leukemiaBirc2 , Birc3 , Fadd , Prkcz
lichen planusRipk1
limited sclerodermaCav1
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
listeriosisCyld , Tnf
liver cancerCasp8
liver cirrhosisStat1 , Tnfrsf1b
liver diseaseNfkb1 , Tnf , Txn1
liver neoplasmMap2k3 , Tnf
Liver Neoplasms, ExperimentalTnf
Liver Reperfusion InjuryCasp8 , Fadd , Ikbkg , Tnf , Tnfrsf1a , Tradd
localized sclerodermaTnf
low tension glaucomaCav1 , Tnf
lung cancerCasp8
lung diseaseTnf
Lung InjuryTnf , Tnfrsf1a
Lung NeoplasmsCasp8 , Ikbkg , Map2k3 , Map2k7 , Map4k4 , Tnf
Lung Reperfusion InjuryTnf
lupus nephritisTnf , Tnfrsf1a , Tnfrsf1b
lymphangioleiomyomatosisStat1
Lymphatic MetastasisCav1 , Rela
lymphomaRela
lymphopeniaTnf
macular degenerationSqstm1
malariaTnf
malignant gliomaCav1 , Tnf
malignant mesotheliomaTxn1
Mammary Neoplasms, ExperimentalCasp8 , Cav1 , Map2k3 , Map2k7 , Rela , Stat1 , Tnf
Manganese PoisoningTnf
mastoiditisRela
melanomaCasp8 , Cav1 , Map3k5 , Nfkb1 , Tnf
Melanoma, ExperimentalIkbkb
membranous glomerulonephritisMap3k5
Meningeal TuberculosisTnf
Mental Retardation, Autosomal Recessive 54Tnik
Metabolic SyndromeFadd , Tnf , Tnfrsf1a
mevalonic aciduriaTnf
Microphthalmia, Syndromic 1Adam17 , Map3k1
middle cerebral artery infarctionFadd , Ikbkb , Tnf
migraineTab2 , Tnf
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
migraine without auraTnf
mitochondrial myopathyTnf
mixed connective tissue diseaseTnf
morphine dependenceFadd
Mouth NeoplasmsRack1
mucocutaneous leishmaniasisTnf
Multiple AbnormalitiesCav1 , Chuk
multiple acyl-CoA dehydrogenase deficiencyMadd
multiple myelomaTnf
Multiple Organ FailureTnf
multiple sclerosisCav1 , Tnf , Tnfaip3 , Tnfrsf1a
Multisystem Autoimmune Disease, with Facial DysmorphismItch
Muscle WeaknessTnfrsf1a
muscular atrophyChuk , Ikbkb , Tnf
muscular dystrophyTnf
Mycobacterium avium complex diseaseTnf
Mycobacterium InfectionsStat1
Mycoplasma pneumoniae pneumoniaTnf
mycosis fungoidesTnfrsf1b
myelodysplastic syndromeTnf
myocardial infarctionMap3k5 , Tnf , Tnfrsf1a , Tnfrsf1b , Txn1
Myocardial IschemiaMap2k3 , Tnf
Myocardial Reperfusion InjuryCasp8 , Fadd , Rela , Stat1 , Tnf , Txn1
myocardial stunningTnf
myocarditisTnf , Txn1
myositisTnf
Nasal PolypsTnf , Tnfrsf1a , Tnfrsf1b
NauseaTnf
NecrosisTnf
Nematode InfectionsTnfrsf1a
NeointimaMap3k5
Neonatal Inflammatory Skin and Bowel DiseaseAdam17
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neoplasm InvasivenessRela , Smpd1 , Tnf , Txn1
Neoplasm MetastasisCav1 , Chuk , Fadd , Nfkb1 , Stat1 , Tnf
nephroblastomaStat1
Nephrogenic Fibrosing DermopathyCav1
Nerve DegenerationTnf
nervous system diseaseTnf
NeuralgiaTnf
neuroblastomaMap2k7
Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy, Childhood-OnsetSqstm1
Neurogenic InflammationTnf , Tnfrsf1a , Tnfrsf1b
neuronal ceroid lipofuscinosis 6Smpd1
Neuropathy, PainfulTnf
neutropeniaTnf
Niemann-Pick diseaseSmpd1
Niemann-Pick disease type ASmpd1
Niemann-Pick disease type BSmpd1
Niemann-Pick Disease, Intermediate, Protracted NeurovisceralSmpd1
non-small cell lung carcinomaCasp8 , Cyld , Rela , Tnf , Tnfrsf1a
Nonaka MyopathySqstm1
nonalcoholic fatty liver diseaseIkbkg , Tnf , Tnfrsf1b
Nonspherocytic Hemolytic Anemia, due to G6PD DeficiencyIkbkg
Nontuberculous Mycobacterium InfectionsStat1
obesityCav1 , Fadd , Ikbkb , Prkci , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
obstructive sleep apneaRela , Tnf , Tnfrsf1a
open-angle glaucomaCav1 , Tnf
Optic Nerve InjuriesTnfrsf1a , Tradd
oral submucous fibrosisTnf
osteoarthritisCav1
OsteolysisTnf
osteoporosisTnfrsf1b
Osteoporosis, PostmenopausalTnf
otitis mediaRela , Tnf
Otitis Media with EffusionTnf
ovarian cystNfkb1
Ovarian NeoplasmsCav1 , Map2k7 , Prkci , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
Oxygen-Induced RetinopathyTnf
Paget's disease of boneSqstm1
PainTnf , Tnfrsf1a
pancreatic cancerBag4 , Casp8 , Rela , Tnf
pancreatitisIkbkb
Pancreatitis, Acute NecrotizingRela
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Tnf
Papillomavirus InfectionsCasp8
paracoccidioidomycosisTnf
Parkinson's diseaseMap3k5 , Tnf , Tnfrsf1b
Parkinsonian DisordersRela , Tnf , Tnfrsf1b
Pediatric Crohn's DiseaseTnf
peptic esophagitisTnf
perinatal necrotizing enterocolitisIkbkg , Map3k5 , Tnf
periodontitisTnf
Peripheral Nerve InjuriesTnf
peritonitisTnf
periventricular leukomalaciaTnf
Picornaviridae InfectionsTnf
placenta diseaseTnf
plasmacytomaTnf
Plasmodium falciparum malariaTnf
pleomorphic xanthoastrocytomaCav1 , Tax1bp1
Pleural EffusionTnf
pleurisyTnf
Pneumococcal MeningitisRela , Tnf
Pneumococcal PneumoniaTnf
pneumoniaIkbkb , Tnf , Tnfrsf1a , Tnfrsf1b
polycystic ovary syndromeTab1
POLYGLUCOSAN BODY MYOPATHY 1 WITH OR WITHOUT IMMUNODEFICIENCYRbck1
PolymyositisTnf , Tnfrsf1a , Tnfrsf1b
pre-eclampsiaTnf , Tnfrsf1b
pre-malignant neoplasmMap2k7
precursor lymphoblastic lymphoma/leukemiaCasp8
precursor T-lymphoblastic lymphoma/leukemiaStat1
Pregnancy Complications, CardiovascularTnf
Premature BirthTnf
primary biliary cirrhosisNfkb1 , Tnfrsf1a
primary immunodeficiency diseaseCasp8
primary open angle glaucomaCav1 , Tnf
primary pulmonary hypertensionCav1
prostate adenocarcinomaChuk , Ikbkb , Rela
prostate cancerChuk , Ikbkb , Nfkb1
prostate carcinoma in situMap2k7 , Rela
prostatic hypertrophyRela
Prostatic NeoplasmsCav1 , Chuk , Map2k7 , Map3k1 , Map3k7 , Prkcz , Rela , Rnf31 , Stat1 , Tnf
Pseudomonas InfectionsTnf , Tnfrsf1a
psoriasisCav1 , Ikbkb , Tnf , Tnfaip3 , Tnfrsf1a
psoriatic arthritisTnf
pulmonary edemaTnf
pulmonary emphysemaTnf
pulmonary fibrosisCav1 , Stat1 , Tnf
pulmonary hypertensionCav1 , Rela , Tnf
Pulmonary Hypertension, Primary, 3Cav1
pulmonary sarcoidosisTnf , Tnfrsf1b
pulmonary tuberculosisTnf
Radiation Injuries, ExperimentalTnf
Radiation PneumonitisTnf , Tnfrsf1a
radiculopathyTnf
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
relapsing polychondritisTnf
renal cell carcinomaBirc2 , Birc3 , Cav1 , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
renal fibrosisTnfrsf1a
renal hypertensionTnf
renovascular hypertensionRela
Reoviridae InfectionsStat1
Reperfusion InjuryCasp8 , Cav1 , Rela , Stat1 , Tnf , Tnfrsf1a , Txn1
respiratory allergyTnf
respiratory syncytial virus infectious diseaseTnf
respiratory system diseaseTnf
Respiratory Tract InfectionsTnf
restrictive cardiomyopathyMap2k3
Retina Reperfusion InjuryTnf
retinal artery occlusionTnf
retinal detachmentTnf , Tnfrsf1a , Tnfrsf1b
retinal diseaseMap2k3 , Tnf
retinitis pigmentosaRipk1
rheumatoid arthritisStat1 , Tnf , Tnfaip3 , Tnfrsf1a
rhinitisTnf
RhinosinusitisTnf
sarcomaTnf
SarcopeniaCav1
schizophreniaMap2k7 , Tnf
sciatic neuropathyCav1 , Tnf , Tnfrsf1a , Tnfrsf1b
SciaticaTnfrsf1b
scleritisTnf
scrapieStat1
Seizures, FebrileTnfrsf1a
sensorineural hearing lossFadd , Tnf
SepsisCasp8 , Rela , Stat1 , Tnf
septic arthritisTnf
Sezary's diseaseTnfrsf1b
ShockTnf
Shock, HemorrhagicRela , Tnf
sickle cell anemiaTnf
silicosisTnf , Tnfrsf1a
Sjogren's syndromeTnf , Tnfaip3
Skin AbnormalitiesChuk
skin cancerChuk
skin diseaseTnf , Tnik
Skin NeoplasmsCasp8 , Cyld , Rela
small cell carcinomaTnf
Smith-Magenis syndromeMap2k3 , Map3k3 , Rffl
Soft Tissue NeoplasmsTnf
Spinal Cord CompressionTnf , Tnfrsf1a , Tnfrsf1b
Spinal Cord InjuriesCav1 , Fadd , Map3k5 , Rela , Tnf , Tnfrsf1a
squamous cell carcinomaCav1 , Rack1 , Ripk1 , Tnfrsf1a
status epilepticusCasp8 , Rela , Tnf
Stevens-Johnson syndromeCav1 , Tnf
Stomach NeoplasmsBirc2 , Casp8 , Cav1 , Tnf
Stomatognathic DiseasesFadd
StrokeTnf
Subarachnoid HemorrhageTnf
Systemic CandidiasisTnf
Systemic Inflammatory Response SyndromeTnfrsf1b
systemic lupus erythematosusTnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b
systemic sclerodermaCav1
TachycardiaTnf
Temporomandibular Joint DisordersMap4k3 , Tnf
thalassemiaTnf
thoracic aortic aneurysmAdam17
thrombocytopeniaTnf
thrombosisTnf
thymomaCyld
Thyroid NeoplasmsMap2k3 , Tnf
Tongue NeoplasmsTnf
toxic shock syndromeTnf
trachomaTnf
transient cerebral ischemiaCav1 , Ikbkb , Madd , Map3k5 , Nfkb1 , Rack1 , Tnf , Tnfrsf1a
transitional cell carcinomaCav1 , Tnf
Transplant RejectionIkbkb , Tnf , Tnfrsf1b
Trauma, Nervous SystemStat1
trichinosisTnf
Trichoepithelioma, Multiple Familial, 2Cyld
trigeminal neuralgiaTnf
tuberculosisTnf , Tnfrsf1b
type 1 diabetes mellitusCasp8 , Tnf
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusAdam17 , Casp8 , Ikbkb , Madd , Nfkb1 , Prkci , Prkcz , Rela , Tnf , Tnfrsf1a , Tnfrsf1b
ulcerative colitisRela , Tnf
ureteral obstructionTnf , Tnfrsf1a , Tnfrsf1b
urinary bladder cancerBirc3 , Cav1 , Rela , Tnf
urticariaTnf
Uterine Cervical NeoplasmsBirc2 , Casp8 , Cyld , Map2k3 , Rela , Tnf
uveitisRela , Tnf , Tnfrsf1a
vascular diseaseTnf
Vascular System InjuriesTnf
Venous ThromboembolismTnf
Ventilator-Induced Lung InjuryMap3k5
Ventricular DysfunctionTnf
Ventricular RemodelingMap3k5
Viral BronchiolitisTnf
viral pneumoniaTnf
visceral leishmaniasisTnf
visual epilepsyMap3k5 , Tnf , Tnfrsf1a , Tnfrsf1b
vitiligoTnf
Vogt-Koyanagi-Harada diseaseTnf
Vulvar VestibulitisTnf
Weight GainCav1 , Tnf
Weill-Marchesani syndromeTnf
Wilson diseaseSmpd1 , Tnf
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesTnf
Wounds, PenetratingTnf
X-linked adrenal hypoplasia congenitaTab3
Pathway Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
adenine phoshoribosyltransferase deficiency pathwayTxn1
adenosine monophosphate deaminase deficiency pathwayTxn1
adenosine signaling pathwayChuk , Ikbkb , Map2k7 , Map3k1 , Nfkb1 , Prkcz
adenylosuccinate lyase deficiency pathwayTxn1
AICA-ribosuria pathwayTxn1
allograft rejection pathwayTnf
Alzheimer's disease pathwayAdam17 , Casp8 , Fadd , Tnf , Tnfrsf1a
amyotrophic lateral sclerosis pathwayMap2k3 , Tnf , Tnfrsf1a , Tnfrsf1b
angiotensin II signaling pathwayPrkcz
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Nfkb1 , Rela , Ripk1 , Tnf , Tnfrsf1a , Tradd , Traf2
asthma pathwayTnf
azathioprine pharmacodynamics pathwayTxn1
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k7 , Map3k1 , Map3k3 , Map3k7 , Traf2
ceramide signaling pathwayBag4 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Madd , Map3k1 , Map4k4 , Nfkb1 , Nsmaf , Prkcz , Rela , Ripk1 , Smpd1 , Stat1 , Tnf , Tnfrsf1a , Tradd , Traf2
Chagas disease pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Nfkb1 , Rela , Tnf , Tnfrsf1a
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Prkcz , Rela , Stat1
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
cytokine mediated signaling pathwayTnf , Tnfrsf1a , Tnfrsf1b
dilated cardiomyopathy pathwayTnf
eicosanoid signaling pathwayPrkcz
endocytosis pathwayCav1 , Itch , Prkci , Prkcz
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Traf2
Entamoebiasis pathwayNfkb1 , Rela , Tnf
ephrin - ephrin receptor bidirectional signaling axisMap3k7 , Map4k4
epidermal growth factor/neuregulin signaling pathwayAdam17 , Map2k7 , Prkcz , Stat1
Erk5 MAPK signaling pathwayMap3k3
erythropoietin signaling pathwayNfkb1 , Stat1
extrinsic apoptotic pathwayCasp8
FasL mediated signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k7 , Map3k1 , Ripk1 , Smpd1
Fc epsilon receptor mediated signaling pathwayMap2k3 , Map2k7 , Tnf
fibroblast growth factor signaling pathwayStat1
gonadotropin-releasing hormone signaling pathwayMap2k3 , Map2k7 , Map3k1 , Map3k3
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Stat1
hepatitis C pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Ripk1 , Stat1 , Tnf , Tnfrsf1a , Tradd , Traf2
Huntington's disease pathwayCasp8
hypertrophic cardiomyopathy pathwayTnf
hypoxia inducible factor pathwayRack1
influenza A pathwayIkbkb , Map2k3 , Map2k7 , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayCav1 , Ikbkb , Prkci , Prkcz
insulin-like growth factor signaling pathwayPrkcz , Rack1
integrin mediated signaling pathwaySharpin
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Map3k3 , Map3k7 , Nfkb1 , Prkci , Prkcz , Rela , Sqstm1 , Tab1 , Tab2 , Tab3
Interleukin-10 signaling pathwayStat1
interleukin-12 signaling pathwayMap2k3 , Nfkb1 , Rela , Stat1
interleukin-2 signaling pathwayStat1
interleukin-23 signaling pathwayNfkb1 , Rela , Stat1 , Tnf
interleukin-27 signaling pathwayStat1 , Tnf
interleukin-6 signaling pathwayAdam17 , Stat1
Jak-Stat signaling pathwayStat1
Kelley-Seegmiller syndrome pathwayTxn1
Leishmaniasis pathwayMap3k7 , Nfkb1 , Rela , Stat1 , Tnf
Lesch-Nyhan syndrome pathwayTxn1
malaria pathwayTnf
measles pathwayChuk , Map3k7 , Nfkb1 , Rack1 , Rela , Stat1
mercaptopurine pharmacodynamics pathwayTxn1
mitochondrial autophagy pathwaySqstm1
mitogen activated protein kinase signaling pathwayChuk , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k1 , Map3k3 , Map3k7 , Map4k2 , Map4k3 , Map4k4 , Nfkb1 , Rela , Tnf , Tnfrsf1a , Traf2
molybdenum cofactor deficiency pathwayTxn1
mTOR signaling pathwayIkbkb
myocarditis pathwayCasp8 , Cav1
neurotrophic factor signaling pathwayIkbkb , Map2k7 , Map3k1 , Map3k3 , Nfkb1 , Rela
NOD-like receptor signaling pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rela , Tnf
Notch signaling pathwayAdam17 , Itch
nuclear factor kappa B signaling pathwayBirc2 , Chuk , Cyld , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Rbck1 , Rela , Rnf31 , Sharpin , Tab1 , Tab2 , Tab3 , Tnf , Tnfrsf1a
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Sqstm1
p38 MAPK signaling pathwayMap2k3 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Tab1 , Tab2 , Traf2 , Txn1
p53 signaling pathwayCasp8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Map3k5
platelet-derived growth factor signaling pathwayCav1 , Map2k7 , Stat1
primary immunodeficiency pathwayIkbkg
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela
protein kinase C (PKC) signaling pathwayPrkci , Prkcz , Rack1
purine metabolic pathwayTxn1
purine nucleoside phosphorylase deficiency pathwayTxn1
Reelin signaling pathwayMap2k7
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Cyld , Fadd , Ikbkb , Ikbkg , Map3k1 , Map3k7 , Nfkb1 , Rela , Ripk1 , Tnf , Tradd , Traf2
reverse cholesterol transport pathwayCav1
rheumatoid arthritis pathwayTnf
ribosome biogenesis pathwayRack1
sleeping sickness pathwayTnf
small cell lung carcinoma pathwayBirc2 , Birc3 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Traf2
sphingolipid metabolic pathwaySmpd1 , Smpd2
syndecan signaling pathwayRack1
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map2k7 , Map3k7 , Nfkb1 , Rela , Tnf
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1
tioguanine pharmacodynamics pathwayTxn1
titanium dioxide nanoparticle response pathwayCasp8
Toll-like receptor signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k7 , Nfkb1 , Rela , Ripk1 , Stat1 , Tab1 , Tab2 , Tab3 , Tnf , Tradd
toxoplasmosis pathwayBirc2 , Birc3 , Casp8 , Chuk , Ikbkb , Ikbkg , Map2k3 , Map3k7 , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a
Trail mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map3k1 , Ripk1 , Smpd1 , Tradd , Traf2
transforming growth factor-beta Smad dependent signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayTnf
tuberculosis pathwayCasp8 , Fadd , Nfkb1 , Rela , Stat1 , Tnf , Tnfrsf1a , Tradd
tumor necrosis factor mediated signaling pathwayAdam17 , Bag4 , Birc2 , Birc3 , Casp8 , Cav1 , Chuk , Cyld , Fadd , Ikbkb , Ikbkg , Itch , Madd , Map2k3 , Map2k7 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Map4k2 , Map4k3 , Map4k4 , Map4k5 , Nfkb1 , Nrk , Nsmaf , Prkci , Prkcz , Rack1 , Rbck1 , Rela , Rffl , Ripk1 , Rnf11 , Rnf31 , Sharpin , Smpd1 , Smpd2 , Sqstm1 , Stat1 , Tab1 , Tab2 , Tab3 , Tax1bp1 , Tnf , Tnfaip3 , Tnfrsf1a , Tnfrsf1b , Tnik , Tradd , Traf2 , Txn1
type 1 diabetes mellitus pathwayTnf
type 2 diabetes mellitus pathwayIkbkb , Prkcz , Tnf
type II interferon signaling pathwayMap3k1 , Stat1
ubiquitin/proteasome degradation pathwayBirc2 , Birc3 , Itch , Map3k1
vascular endothelial growth factor signaling pathwayCav1 , Map2k3 , Prkcz
Wnt signaling pathwayMap3k7
Wnt signaling, canonical pathwayCav1
Wnt signaling, non-canonical pathwayMap3k7 , Prkcz , Tab1 , Tab2
xanthinuria type I pathwayTxn1
xanthinuria pathwayTxn1
xanthinuria type II pathwayTxn1
Phenotype Annotations Associated with Genes in the tumor necrosis factor mediated signaling pathway

References Associated with the tumor necrosis factor mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: