PHOSPHATIDYLINOSITOL 3-KINASE-AKT SIGNALING PATHWAY (PW:0000232)

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Description

The phosphatidylinositol 3-kinase-Akt signaling pathway plays a crucial role in many cellular processes. The PI3K generally referenced is the class IA lipid kinase acting downstream of receptor tyrosine kinases (RTKs). PI3Ks represent a large family of lipid kinases that phosphorylate the 3-hydroxy group of the inositol ring of membrane phosphatidylinositols (PtsIns). Based on substrate preferences and sequence similarity, they are divided into three classes: class I, II and III. Class I is furt

Pathway Diagram:

Elsevier Inc. Nfe2l2 signaling pathway insulin responsive facilitative sugar transporter mediated glucose transport pathway mTOR signaling pathway forkhead class O signaling pathway Pp2a complex Pi3k-Akt cytoplasmic targets Pi3k-Akt nuclear targets P-T308 Pp2a complex ---| Akt1 mTORC2 complex --+> Akt1 Pik3 regulatory subunit Inppl1 ---| PIP3 PIP3 Inppl1 Inpp5d ---| PIP3 Inppl1 ---> PIP3 Inpp5d ---> PIP3 Inpp5d Pten ---| PIP3 Pten cell survival cell growth cell proliferation Pik3 regulatory subunit ---- Pik3ca Pik3ca Pik3 regulatory subunit ---- Pik3cd Pik3cd Pik3 regulatory subunit ---- Pik3cb Pik3cb P-tyrosine ---- Pik3 regulatory subunit P-tyrosine Phlpp2 ---| activated Akt members activated Akt members Phlpp2 Phlpp1 ---| activated Akt members Phlpp1 Pp2a complex ---| activated Akt members Pten ---> PIP3 Akt1 Pdpk1 --+> Akt1 Phlpp2 ---| Akt3 Phlpp2 ---| Akt2 Akt2 Phlpp1 ---| Akt3 Phlpp1 ---| Akt2 Akt3 P-S473 activated Akt members --+> insulin responsive facilitative sugar transporter mediated glucose transport pathway activated Akt members --+> mTOR signaling pathway activated Akt members ---> cell proliferation activated Akt members ---| forkhead class O signaling pathway Pdpk1 activated Akt members ---> cell survival Akt1 ---- PIP3 Akt3 ---- PIP3 Akt2 ---- PIP3 Pik3cb ---> PIP2 Pik3ca ---> PIP3 activated Akt members ---> cell growth receptor tyrosine kinase PIP2 Pik3ca ---> PIP2 Pik3cb ---> PIP3 Pdpk1 ---- PIP3 mTORC2 complex activated Akt members --+> Nfe2l2 signaling pathway
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Genes in Pathway:

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phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:625444
RGD:6484113
RGD:2290458
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:632179
RGD:6484113
RGD:2290458
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2290458
RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6484113
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6484113
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6484113
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6484113
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6484113
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6484113
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6484113
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:2302068
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:2302068
G Kpna1 karyopherin subunit alpha 1 JBrowse link 11 67,652,573 67,717,180 RGD:6484113
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
G Mapkap1 mitogen-activated protein kinase associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:6484113
G Mlst8 MTOR associated protein, LST8 homolog JBrowse link 10 13,839,250 13,845,001 RGD:6484113
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:2290458
RGD:6484113
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 JBrowse link 13 26,145,989 26,394,505 RGD:11535053
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:11535053
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2290458
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:2290458
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:2290458
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:2290458
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:2290458
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:2290458
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:11535052
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:11535052
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:11535052
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:11535052
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 15 43,673,958 43,733,182 RGD:11535052
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:6484113
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2290458
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6484113
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:6484113
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6484113
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6484113
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6484113
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:6484113
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon JBrowse link 10 63,884,338 63,921,709 RGD:6484113
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6484113
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta JBrowse link 14 83,053,041 83,062,424 RGD:6484113
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6484113
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta JBrowse link 7 75,573,553 75,598,295 RGD:6484113
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:2313763
RGD:5133243
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313763
RGD:2313408
RGD:5490965
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2313763
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2313763
RGD:4143515
RGD:5133242
RGD:5133243
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2313763
RGD:5490965
RGD:5133242
RGD:4143515
RGD:2326139

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupAkt nuclear targets
Functional Classactivated Akt members
Gene GroupPi3k-Akt cytoplasmic targets

Pathway Gene Annotations

Disease Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGsk3b
acoustic neuromaCdkn1a
acute kidney failureBad , Cdkn1b , Gsk3b , Mtor
acute lymphocytic leukemiaPten
acute myeloid leukemiaCdkn1b , Foxo1
acute promyelocytic leukemiaAkt1
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaMtor , Pik3ca , Pten
adenoid cystic carcinomaFoxo3 , Pik3ca , Prkdc , Pten
adrenal carcinomaPik3ca
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsPrkaca
adrenocortical carcinomaPik3ca
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS-Associated NephropathyMtor
alcohol-induced mental disorderFoxo4
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseAkt1 , Bad , Foxo3 , Gsk3a , Gsk3b , Hsp90aa1 , Pik3r1 , Slc2a4
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Bad , Casp9 , Gsk3a , Gsk3b , Map3k5
anaplastic large cell lymphomaHsp90aa1
angiomyolipomaPten
Animal Disease ModelsAkt1
anisometropiaPten
Aortic Valve, Calcification ofAkt1
Arsenic PoisoningCdkn1a
Arterial InjuryMap3k5
asthmaChuk , Ppp2ca , Pten
astrocytomaAkt1 , Akt2 , Akt3
AtaxiaPten
atherosclerosisAkt1
atrial fibrillationCdkn1a
autistic disorderPten
autosomal dominant non-syndromic intellectual disability 36Ppp2r1a
autosomal dominant polycystic kidney diseaseCdkn1a , Mtor
autosomal recessive polycystic kidney diseaseAkt1 , Mtor , Pik3ca , Src
bacterial infectious diseaseCasp9
bacterial pneumoniaChuk
Bannayan-Riley-Ruvalcaba syndromePik3ca , Pten
Bardet-Biedl syndromeAkt3
Barrett's esophagusCdkn1a
basal cell carcinomaPik3ca
biliary atresiaPten
bipolar disorderAkt1 , Gsk3a , Gsk3b
bladder urothelial carcinomaAkt1 , Pik3ca
bone development diseaseChuk
Bowen's DiseaseCdkn1a
brain diseasePten
Brain InjuriesAkt1 , Bad , Cdkn1a , Cdkn1b , Gsk3b
brain ischemiaAkt1 , Bad , Casp9 , Prkaca , Src , Ywhab
Brain NeoplasmsPik3ca , Pik3r1 , Pten
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Mtor , Pik3ca , Ppp2r1a , Pten
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Bad , Casp9 , Cdkn1a , Cdkn1b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3r1 , Ppp2r1a , Pten , Raf1 , Src
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsBad , Gsk3b , Mtor
cannabis abuseAkt1
capillary hemangiomaAkt3
carcinomaCdkn1a , Pik3r1 , Pten , Ywhaz
cardiac arrestAkt1
CardiomegalyAkt1 , Bad , Gsk3b , Mtor , Pten , Raf1 , Slc2a4 , Src
cardiomyopathyAkt1 , Map3k5 , Ywhah
Cardiomyopathy, Hypertrophic, FamilialRaf1
Carotid Artery InjuriesFoxo3 , Map3k5
cataractPten
Cell Transformation, NeoplasticPhlpp1 , Pten
cerebral cavernous malformationPten
Cerebral HemorrhageMtor
cerebral infarctionMap3k5
cervix uteri carcinoma in situCdkn1a , Cdkn1b , Pten
Chemical and Drug Induced Liver InjuryBad , Map3k5 , Prkdc
childhood absence epilepsyYwhaz
ChloracneCdkn1b
cholangiocarcinomaPrkaca , Pten
cholesteatoma of middle earCdkn1a
Cholesteatoma, CongenitalCdkn1a
chondrosarcomaMtor
choroid plexus carcinomaFoxo3
Chromosomal InstabilityPpp2r2a
Chronic Allograft DysfunctionMtor
Chronic Cerebral HypoperfusionMap3k5
chronic myeloid leukemiaAkt1 , Cdkn1b
chronic obstructive pulmonary diseaseFoxo3
cleft palateChuk
cocoon syndromeChuk
Cognition DisordersGsk3b , Map3k5
Cognitive DysfunctionHsp90aa1
colitisChuk , Src
colon adenocarcinomaPik3r3
colon cancerAkt1 , Pik3ca , Src
colon carcinomaAkt1 , Pik3ca
Colonic NeoplasmsAkt2 , Akt3 , Bad , Cdkn1a , Gsk3b , Pik3ca , Pik3r1 , Pik3r2 , Pten , Src
colorectal adenocarcinomaCdkn1a , Gsk3b , Raf1
colorectal adenomaRaf1
colorectal cancerAkt1 , Pik3ca , Src
Colorectal NeoplasmsAkt1 , Akt2 , Casp9 , Mtor , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Ppp2r1a , Pten , Raf1 , Src
complex cortical dysplasia with other brain malformationsAkt3 , Mtor , Pik3ca
Congenital Limb DeformitiesChuk
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congenital myasthenic syndrome 4CPten
congestive heart failureFoxo1 , Gsk3b , Map3k5 , Mtor , Pdpk1 , Ppp2ca , Prkaca , Slc2a4
contact dermatitisHsp90aa1
coronary artery diseaseAkt1
Cowden diseaseAkt1 , Pik3ca , Pten
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
Craniofacial AbnormalitiesPten
crescentic glomerulonephritisMtor
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Pik3ca , Ppp2ca , Pten , Raf1
DehydrationYwhaz
dermoid cyst of ovaryFoxo3
developmental coordination disorderPten
Developmental DisabilitiesAkt3 , Pik3r2 , Pten
diabetes mellitusMap3k5 , Pten
Diabetes Mellitus, New-Onset after TransplantationMtor
Diabetic CardiomyopathiesBad
Diabetic CystopathyBad
Diabetic NephropathiesCdkn1a , Cdkn1b , Mtor , Pten
diabetic neuropathyBad
diabetic retinopathyCasp9
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd
dilated cardiomyopathyGsk3a , Raf1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationPik3ca , Pik3r1 , Pten , Src
Disease ProgressionPik3ca , Ppp2r1a , Pten
Drug-Induced DyskinesiaMtor
ductal carcinoma in situCdkn1a , Src
dysplastic nevus syndromePten
EdemaCasp9
EmphysemaPpp2r2a
end stage renal failureMtor
endometrial cancerPik3cb , Pik3r1 , Pten
endometrial carcinomaGsk3b , Mlst8 , Pik3ca , Pik3r1 , Pten
Endometrial HyperplasiaPten
Endometrial NeoplasmsAkt2 , Bad , Cdkn1a , Cdkn1b , Foxo3 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pten , Sfn
Endometrioid CarcinomasAkt1 , Cdkn1b , Pik3r2 , Pten
epidermal nevusPik3ca
epilepsyAkt1
esophageal carcinomaPik3ca
Esophageal NeoplasmsCdkn1a , Pik3ca , Sfn
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaCdkn1a , Sfn
Experimental ArthritisAkt1 , Gsk3b , Map3k5 , Mtor , Pik3cd
Experimental Autoimmune EncephalomyelitisCasp9 , Foxo3
Experimental Diabetes MellitusAkt1 , Bad , Casp9 , Cdkn1a , Foxo3 , Gsk3a , Hsp90aa1 , Map3k5 , Mtor , Pik3r1 , Slc2a4 , Ywhah
Experimental Liver CirrhosisCdkn1a , Inpp5d , Inppl1 , Mtor , Ywhag , Ywhaz
Facial AsymmetryPik3ca
facioscapulohumeral muscular dystrophyCdkn1a
Fallopian Tube NeoplasmsCdkn1b
familial adenomatous polyposisAkt1
familial meningiomaPten
familial partial lipodystrophyAkt2
fatty liver diseasePten
fetal alcohol spectrum disorderPten
Fetal DiseasesChuk
FibrosisAkt1 , Cdkn1b
Focal Cortical Dysplasia of TaylorMtor
Follicular Thyroid CancerPten
follicular thyroid carcinomaPten
Frontotemporal Lobar DegenerationHsp90aa1
Fuchs' endothelial dystrophyCdkn1a
gastric adenocarcinomaAkt1 , Mtor , Pik3ca , Ppp2r1a , Pten , Raf1
gastric ulcerBad , Foxo4
Gastrointestinal NeoplasmsPik3ca , Pten
genetic diseaseAkt2 , Akt3 , Mtor , Pik3ca , Pik3r1 , Pik3r2 , Ppp2r1a , Pten , Raf1 , Rictor
glaucomaBad , Cdkn1b
glioblastoma multiformeAkt1 , Akt3 , Mtor , Pik3ca , Pik3r1 , Pten
Growth DisordersPik3ca
growth hormone secreting pituitary adenomaCdkn1a
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaAkt1 , Pik3ca , Ppp2r1a , Pten
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a
heart diseaseCasp9 , Ppp2ca
Helicobacter InfectionsCdkn1b
hemangiomaPten
HemimegalencephalyMtor , Pik3ca
hepatic encephalopathyPrkdc
hepatocellular adenomaCdkn1b , Pten
hepatocellular carcinomaAkt1 , Akt2 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Pten , Sfn
HepatomegalyPten
Hereditary Neoplastic SyndromesCdkn1b , Pik3ca , Ppp2ca , Pten
human immunodeficiency virus infectious diseaseCdkn1a , Hsp90aa1
Huntington's diseaseCasp9 , Map3k5
HyperalgesiaMtor , Ppp2ca , Raf1
hyperinsulinismPten
HyperoxiaCdkn1a
HyperplasiaAkt1 , Cdkn1a , Pik3ca
hypertensionAkt1 , Akt2 , Bad , Gsk3b , Inppl1 , Mtor , Pik3r1 , Pten , Src , Ywhaz
HypertriglyceridemiaMtor
hypertrophic cardiomyopathyPrkaca , Raf1
HypertrophyCdkn1a , Pten
Hypertrophy, Left VentricularCdkn1b , Foxo3 , Gsk3a , Mtor , Pten
Hypertrophy, Right VentricularAkt1 , Mtor
Hypoglossal Nerve InjuriesPrkaca
hypoglycemiaAkt2 , Inppl1 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypothyroidismBad
HypovolemiaCdkn1a
Hypoxia-Ischemia, BrainFoxo3 , Map3k5
idiopathic interstitial pneumoniaMtor
Immunodeficiency 14Pik3cd
IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIESPrkdc
Immunodeficiency 36Pik3r1
impotenceAkt1 , Bad
in situ carcinomaAkt1 , Pten , Sfn
infantile epileptic encephalopathy 56Ywhag
InflammationAkt1 , Chuk , Mtor
Insulin ResistanceAkt2 , Bad , Foxo1 , Inppl1 , Pik3r1 , Pten , Slc2a4
intellectual disabilityPten
intermediate coronary syndromeAkt1
intermittent claudicationBad
interstitial cystitisMtor
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsCdkn1a , Cdkn1b , Gsk3b
intestinal pseudo-obstructionPten
Intimal HyperplasiaFoxo3
invasive ductal carcinomaAkt1
inverted papillomaCdkn1a
ischemiaAkt2 , Raf1
KeloidSfn
keratoconusFoxo1
kidney angiomyolipomaMtor
kidney diseaseCdkn1a
Kidney NeoplasmsAkt1 , Cdkn1b , Raf1
Kidney Reperfusion InjuryMap3k5 , Src
Language Development DisordersPten
Laryngeal NeoplasmsCdkn1a
left ventricular noncompactionYwhae
leiomyomaPten
LEOPARD syndromePten , Raf1
LEOPARD Syndrome, 2Raf1
leukemiaBad , Pten
LeukoencephalopathiesCdkn1b
Leydig cell tumorCdkn1b
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
lipomaPten
lipomatosisPten
liver cancerAkt1 , Pik3ca
liver neoplasmCdkn1a , Cdkn1b , Raf1
Liver Neoplasms, ExperimentalCdkn1a , Ppp2ca
Liver Reperfusion InjuryBad
localized sclerodermaCdkn1a
long QT syndromePten
lung adenocarcinomaAkt1 , Foxo3 , Pik3ca , Pik3r1 , Ppp2r1a , Raf1 , Sfn
lung cancerPik3ca , Ppp2r1b
lung diseasePrkdc
Lung InjuryMtor
Lung NeoplasmsAkt1 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Ppp2r1b , Pten , Raf1
lung small cell carcinomaAkt1 , Cdkn1b , Pik3ca , Pten
lung squamous cell carcinomaAkt1 , Pik3ca , Pten
lupus nephritisMtor
LymphangiectasisRaf1
Lymphatic MetastasisCasp9 , Cdkn1a , Cdkn1b , Pdpk1 , Pik3ca , Pik3cb , Pten , Sfn
lymphomaPten
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationBad , Cdkn1a , Cdkn1b
Malformations of Cortical Development, Group IIPten
malignant gliomaAkt2 , Bad , Pik3ca , Pten , Raf1
malignant mesotheliomaCdkn1a , Raf1
Mammary Neoplasms, AnimalCdkn1a , Pik3r1 , Ywhaz
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Cdkn1b , Mtor , Pik3r1 , Pten , Ywhaz
mantle cell lymphomaGsk3b , Mtor , Pik3cd
Massive Hepatic NecrosisPrkdc
maxillary sinus neoplasmCdkn1a
medulloblastomaFoxo3 , Pik3ca
megakaryocytic leukemiaPten
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Cdkn1a , Map3k5 , Mtor , Pik3ca , Pik3r1 , Ppp2ca , Pten , Raf1
membranoproliferative glomerulonephritisCdkn1b
membranous glomerulonephritisCdkn1b , Map3k5
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pten
mental depressionGsk3a , Gsk3b
MesotheliomaCdkn1b , Mtor
Metabolic SyndromeInppl1
Micronuclei, Chromosome-DefectivePpp2r2a
middle cerebral artery infarctionBad , Mtor
Miller-Dieker lissencephaly syndromeYwhae
Mouth NeoplasmsPik3ca , Pten , Sfn
Multiple AbnormalitiesChuk , Gsk3b , Pik3r2 , Pten
Multiple Endocrine NeoplasiaCdkn1b
multiple endocrine neoplasia type 4Cdkn1b
Multiple Hamartoma SyndromePik3ca , Pten
multiple myelomaPik3ca
muscular atrophyAkt1 , Chuk , Gsk3b , Mtor
muscular dystrophyPten
Muscular Dystrophy, AnimalMtor
myelodysplastic syndromeCdkn1b
myocardial infarctionAkt1 , Cdkn1b , Gsk3b , Map3k5 , Mtor
Myocardial IschemiaPpp2ca
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Gsk3b , Pten , Slc2a4
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaAkt2 , Pik3ca , Pten
Nematode InfectionsPik3r1
NeointimaFoxo4 , Map3k5
Neoplasm InvasivenessPten , Src
Neoplasm MetastasisAkt2 , Cdkn1a , Chuk , Hsp90aa1 , Mtor , Pik3ca , Pik3r3 , Pten , Src , Ywhae
Neoplasm Recurrence, LocalYwhaz
nephritisMtor
nephroblastomaCdkn1b
Nerve Sheath NeoplasmsPten
nervous system diseaseCasp9
neuroblastomaPik3ca
Neurodevelopmental DisordersPten
neuroendocrine tumorCdkn1b
neuronal ceroid lipofuscinosis 6Gsk3b
non-Hodgkin lymphomaPik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1b , Foxo3 , Pdpk1 , Pik3ca , Pten , Raf1
Noonan syndromeRaf1
Noonan syndrome 3Raf1
Noonan syndrome 5Raf1
obesityAkt1 , Akt2 , Bad , Cdkn1b , Foxo3 , Inppl1 , Mtor , Pik3r1
ocular hypertensionCdkn1a
OpsismodysplasiaInppl1
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a
osteoarthritisBad , Mtor , Ppp2r1a , Ywhaq
Osteoarthritis, KneeHsp90aa1
osteochondrodysplasiaPten
osteosarcomaAkt1
ovarian cancerAkt1 , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Cdkn1a , Cdkn1b , Gsk3b , Mtor , Pik3ca , Pik3r1 , Pten , Sfn
ovarian serous cystadenocarcinomaPik3ca , Ppp2r1a
Paget's disease of boneInpp5d
PainAkt1
pancreatic adenocarcinomaPik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mtor , Pten
pancreatic carcinomaCdkn1a , Mtor
pancreatic ductal carcinomaCdkn1a
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Cdkn1a
papillomaCdkn1a
paraplegiaAkt1 , Foxo4
Parkinson's diseaseAkt1 , Casp9 , Gsk3b , Map3k5 , Ppp2ca
Parkinsonian DisordersBad , Casp9 , Gsk3a , Mtor , Src
Pena Shokeir Syndrome, Type 1Pten
penile neoplasmPik3ca
perinatal necrotizing enterocolitisMap3k5
peripheral nervous system diseaseCasp9
peripheral nervous system neoplasmPten
peritonitisGsk3b
persistent fetal circulation syndromePten
Phyllodes TumorCdkn1a
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary NeoplasmsCdkn1a , Cdkn1b
plasmacytomaPik3ca
pleomorphic xanthoastrocytomaYwhag
PoisoningGsk3b , Prkdc
Polycystic Kidney DiseasesMtor
polycystic ovary syndromeAkt2
polydactylyPten
PolymicrogyriaAkt3
portal hypertensionHsp90aa1 , Mtor , Pik3r1 , Pten
pre-malignant neoplasmAkt1
precursor T-lymphoblastic lymphoma/leukemiaMtor
Premature AgingCdkn1a , Foxo1
primary biliary cirrhosisCdkn1a
primary hyperparathyroidismCdkn1b
primary open angle glaucomaCdkn1a
primary pigmented nodular adrenocortical diseasePrkaca
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Ppp2r1a , Pten , Raf1
prostate cancerAkt2 , Akt3 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Ppp2ca , Pten , Raf1
Prostate Cancer, SomaticPten
prostate carcinomaAkt2
prostate carcinoma in situCdkn1b , Pten
prostatic hypertrophyBad , Pten
Prostatic NeoplasmsAkt1 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Foxo3 , Gsk3b , Mtor , Phlpp1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Ppp2ca , Ppp2r2a , Prkdc , Pten , Src
Proteus syndromeAkt1 , Pten
psoriasisCdkn1a
PTEN hamartoma tumor syndromePik3ca , Pten
pulmonary fibrosisBad
pulmonary hypertensionCdkn1a , Cdkn1b , Foxo1 , Mtor , Slc2a4
RASopathiesRaf1
rectal neoplasmCdkn1b , Pik3ca , Pik3cb
renal carcinomaMtor , Pik3ca , Pten
renal cell carcinomaAkt1 , Akt3 , Bad , Cdkn1b , Mtor , Pik3ca , Pik3r1 , Pten
renal hypertensionCdkn1a
Reperfusion InjuryAkt1 , Bad , Casp9 , Cdkn1a , Cdkn1b , Inpp5d , Pik3r1 , Pten , Src
Retina Reperfusion InjuryBad
retinal detachmentCasp9
Retinal NeovascularizationMtor
retinitis pigmentosaPten
rheumatoid arthritisFoxo3 , Hsp90aa1
Salivary Gland NeoplasmsCdkn1a
sarcoidosisCdkn1a
sarcomaPik3ca
SarcopeniaCdkn1a , Foxo4
schizophreniaAkt1 , Gsk3a , Gsk3b , Kpna1 , Mtor , Pik3cb , Ywhah , Ywhaz
Schnyder corneal dystrophyMtor
sciatic neuropathyCdkn1b , Mtor
sebaceous gland neoplasmCdkn1a
seborrheic keratosisPik3ca
senile cataractCdkn1b
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisBad , Cdkn1a , Gsk3b , Mtor
Septic PeritonitisPik3r1
serous cystadenocarcinomaCdkn1a
severe combined immunodeficiencyPrkdc
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positivePrkdc
Sezary's diseaseCdkn1b , Pten
Shock, HemorrhagicBad , Mtor
SHORT SyndromePik3r1
Sinonasal NeoplasmsCdkn1a
Skin AbnormalitiesChuk
skin cancerChuk
skin diseasePten
skin melanomaPten
Skin NeoplasmsAkt1 , Cdkn1a
small cell carcinomaMtor
Small-For-Size SyndromeBad
Smith-Kingsmore SyndromeMtor
Spinal Cord InjuriesAkt1 , Cdkn1b , Foxo3 , Map3k5 , Mtor
Spinal Cord Reperfusion InjuryBad
Sporadic Papillary Renal Cell CarcinomaMtor , Pik3ca
squamous cell carcinomaAkt1 , Cdkn1a , Pik3ca , Prkdc , Sfn
status epilepticusFoxo3 , Gsk3b , Mtor , Src
stomach cancerPik3ca
stomach diseasePten
Stomach NeoplasmsCdkn1a , Cdkn1b , Pik3ca , Ppp2r1a
StrokeAkt1 , Pik3ca , Src
substance-induced psychosisAkt1
substance-related disorderPten
systemic lupus erythematosusCdkn1a , Ywhab
T-Cell LymphomaAkt1 , Cdkn1a
Tachycardia, VentricularRaf1
tauopathyGsk3b
temporal lobe epilepsyFoxo3 , Mtor
Temporomandibular Joint DisordersMtor
Testicular NeoplasmsCdkn1b
THROMBOCYTOPENIA 6Src
thrombosisPik3cb
Thyroid NeoplasmsAkt1 , Akt2 , Cdkn1a , Pik3ca , Pten
Tongue NeoplasmsCdkn1a
tongue squamous cell carcinomaCdkn1a
toxic encephalopathyMtor
transient cerebral ischemiaBad , Casp9 , Map3k5 , Pten
transitional cell carcinomaAkt1 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Pten , Sfn
Tumor Predisposition SyndromePten
type 1 diabetes mellitusCasp9 , Foxo1
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Casp9 , Foxo1 , Gsk3b , Inppl1 , Mtor , Pik3cb , Pik3r1 , Ppp2ca , Slc2a4 , Src
ulcerative colitisCdkn1a
ureteral obstructionAkt1 , Mtor
urinary bladder cancerAkt1 , Casp9 , Cdkn1a , Cdkn1b , Mtor , Pten , Sfn , Src
uterine carcinosarcomaPik3ca , Pik3r1 , Ppp2r1a , Pten
Uterine Cervical NeoplasmsAkt1 , Cdkn1a , Cdkn1b , Mtor , Pik3ca , Pten
Uterine NeoplasmsCdkn1b , Mtor , Pik3ca , Pik3r1 , Ppp2r1a , Pten
VACTERL associationPten
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9
vascular dementiaMtor
Vascular MalformationsPik3ca
Ventilator-Induced Lung InjuryAkt1 , Map3k5
Ventricular RemodelingMap3k5
visual epilepsyBad , Map3k5 , Pik3ca , Pten , Ywhab , Ywhaz
vitiligoPik3r1
Vulvar NeoplasmsSfn
Weight GainPik3ca
Williams-Beuren syndromeSrc
Pathway Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Chuk , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp2ca
adenosine signaling pathwayAkt1 , Bad , Chuk , Pdpk1 , Pik3ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Sfn
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Reelin signaling pathwaySrc
Alzheimer's disease pathwayBad , Casp9 , Gsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
amyotrophic lateral sclerosis pathwayBad , Casp9
androgen signaling pathwayHsp90aa1
angiotensin II signaling pathwayPdpk1
antigen processing and presentation pathwayHsp90aa1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
basal cell carcinoma pathwayGsk3b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca
bisoprolol pharmacodynamics pathwayPrkaca
Bone morphogenetic proteins signaling pathwayGsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium/calcium-mediated signaling pathwayPrkaca
calcium/calmodulin dependent kinase 2 signaling pathwayPpp2ca
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCdkn1a , Cdkn1b , Gsk3b , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Foxo3 , Gsk3a , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
cortisol signaling pathwayHsp90aa1
dilated cardiomyopathy pathwayPrkaca
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayPpp2ca , Ppp2cb , Prkaca , Src
E-cadherin signaling pathwayAkt1 , Akt2 , Pik3ca , Pik3r1 , Src
eicosanoid signaling pathwayAkt1 , Prkaca , Src
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwaySrc
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1
endothelin signaling pathwayAkt1 , Raf1 , Src
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca
ephrin - ephrin receptor bidirectional signaling axisInppl1 , Pik3ca , Pik3r1 , Src
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Cdkn1b , Gsk3b , Hsp90aa1 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Src
erythropoietin signaling pathwayInpp5d , Pik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayHsp90aa1 , Src
facilitative sugar transporter mediated glucose transport pathwaySlc2a4
FasL mediated signaling pathwayAkt1 , Chuk , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Src
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Inpp5d , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3r1 , Src
flecainde pharmacodynamics pathwayPrkaca
forkhead class A signaling pathwayAkt1 , Cdkn1b
fosphenytoin pharmacodynamics pathwayPrkaca
G1/S transition pathwayCdkn1a , Cdkn1b
glioma pathwayAkt1 , Akt2 , Akt3 , Cdkn1a , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
glutamate signaling pathwayPrkaca
glycogen biosynthetic pathwayGsk3a , Gsk3b
glypican signaling pathwaySrc
gonadotropin-releasing hormone signaling pathwayPrkaca , Raf1 , Src
granulocyte-macrophage colony-stimulating factor signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Raf1 , Ywhaz
Hedgehog signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Raf1
histone modification pathwayYwhaz
Huntington's disease pathwayCasp9
hypoxia inducible factor pathwayAkt1
ibutilide pharmacodynamics pathwayPrkaca
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Kpna1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayInppl1 , Pik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b , Sfn , Slc2a4 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo1 , Foxo3 , Gsk3b , Inpp5d , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Slc2a4
insulin-like growth factor signaling pathwayAkt1 , Bad , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Ywhae , Ywhaz
interleukin-1 signaling pathwayChuk , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayPik3ca , Pik3r1 , Raf1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayInpp5d , Pik3ca , Pik3r1 , Prkaca , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Inpp5d , Mtor , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Foxo1 , Pik3ca , Pik3r1
intrinsic apoptotic pathwayBad , Casp9
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Raf1
long term potentiationPrkaca , Raf1
measles pathwayAkt1 , Akt2 , Akt3 , Cdkn1b , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Cdkn1a , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitochondrial autophagy pathwaySrc
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Prkaca , Raf1
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Rictor , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
myocarditis pathwayCasp9
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
nerve growth factor signaling pathwaySrc
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Foxo3 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1 , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
NOD-like receptor signaling pathwayChuk , Hsp90aa1
non-homologous end joining pathway of double-strand break repairPrkdc
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Notch signaling pathwayCdkn1a
nuclear factor kappa B signaling pathwayChuk , Pik3ca , Pik3r1 , Src
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
p38 MAPK signaling pathwayMap3k5
p53 signaling pathwayAkt1 , Casp9 , Cdkn1a , Gsk3b , Ppp2ca , Pten , Sfn
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
Parkinson's disease pathwayCasp9
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hsp90aa1 , Inpp5d , Inppl1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Src
phosphatidylinositol 3-kinase signaling pathwayInpp5d , Inppl1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Foxo3 , Foxo4 , Gsk3a , Gsk3b , Hsp90aa1 , Inpp5d , Inppl1 , Kpna1 , Map3k5 , Mapkap1 , Mlst8 , Mtor , Pdpk1 , Phlpp1 , Phlpp2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Ppp2r2a , Prkaca , Prkdc , Pten , Raf1 , Rictor , Sfn , Slc2a4 , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
phosphoinositide metabolic pathwayInpp5d , Pik3ca , Pik3cd , Pik3r1 , Pten
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ppp2ca , Ppp2r1a , Pten , Raf1 , Sfn , Src , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prion disease pathwayPrkaca
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Cdkn1a , Cdkn1b , Chuk , Foxo1 , Gsk3b , Hsp90aa1 , Mtor , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
protein kinase A (PKA) signaling pathwayPrkaca
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1 , Phlpp1 , Phlpp2
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Src
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Src
signaling pathway pertinent to the brain and nervous systemSrc
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Casp9 , Cdkn1b , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten
somatostatin signaling pathwaySrc
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Src
syndecan signaling pathwayPrkaca , Src
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayRaf1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Trail mediated signaling pathwayChuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Raf1 , Src
tumor necrosis factor mediated signaling pathwayChuk , Map3k5
type 2 diabetes mellitus pathwayAkt2 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Slc2a4
type II interferon signaling pathwayAkt1 , Mtor , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwaySrc
urinary bladder cancer pathwayCdkn1a , Raf1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Hsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Prkaca , Raf1 , Src
vasopressin signaling pathway via receptor type 2Prkaca
verapamil pharmacodynamics pathwayPrkaca
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayGsk3b , Ppp2ca , Ppp2cb , Ppp2r1a , Ppp2r1b , Prkaca
Wnt signaling, canonical pathwayGsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the phosphatidylinositol 3-kinase-Akt signaling pathway

References Associated with the phosphatidylinositol 3-kinase-Akt signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: