JAK-STAT SIGNALING PATHWAY (PW:0000209)

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Description

Jak-Stat pathway is a main intracellular cascade initiated in response to cytokine signaling. In mammals, four Janus kinases (JAK) and seven Stat family members mediate the action of almost 40 cytokines receptors including the receptor for leptin. While leptin is not a cytokine, its receptor bears structural similarity to class I cytokine receptor family. In addition, other receptors through their interactions with members of the Jak family, may trigger the Jak-Stat cascade. In the current model

Pathway Diagram:

Ariadne Genomics Inc. phosphatases ---| Stat members phosphatases ---| Jak members Jak members --+> Stat members Jak members --+> leptin, cytokines, other receptors leptin, cytokines, other receptors --+> Jak members Pias members translocated Stat phosphatases Stat target genes Jak members Socs members Stat members leptin, cytokines, other receptors translocated Stat ---> Stat target genes Pias members ---| translocated Stat translocated Stat ---> Socs members Jak members ---- leptin, cytokines, other receptors leptin, cytokines, other receptors ---- Stat members Stat members ---> translocated Stat Socs members ---| leptin, cytokines, other receptors Socs members ---| Jak members PYs
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Genes in Pathway:

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Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6907045
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:6907045
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6907045
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6907045
G Cish cytokine inducible SH2-containing protein JBrowse link 8 116,054,547 116,059,494 RGD:6907045
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 1 219,468,866 219,472,445 RGD:6907045
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:6907045
G Cntfr ciliary neurotrophic factor receptor JBrowse link 5 58,041,114 58,078,687 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Crlf2 cytokine receptor-like factor 2 JBrowse link 14 1,456,843 1,461,543 RGD:6907045
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6907045
G Csf2ra colony stimulating factor 2 receptor alpha subunit JBrowse link 14 1,462,292 1,467,264 RGD:6907045
G Csf2rb colony stimulating factor 2 receptor beta common subunit JBrowse link 7 119,554,383 119,568,248 RGD:6907045
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6907045
G Csf3r colony stimulating factor 3 receptor JBrowse link 5 144,031,353 144,051,966 RGD:6907045
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6907045
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:6907045
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6907045
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6907045
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6907045
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6907045
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6907045
G Ifngr2 interferon gamma receptor 2 JBrowse link 11 31,694,339 31,712,611 RGD:6907045
G Ifnk interferon kappa JBrowse link 5 50,631,217 50,634,142 RGD:6907045
G Ifnl3 interferon, lambda 3 JBrowse link 1 85,236,243 85,237,775 RGD:6907045
G Ifnlr1 interferon, lambda receptor 1 JBrowse link 5 154,037,243 154,058,862 RGD:6907045
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6907045
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6907045
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:6907045
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6907045
G Il11ra1 interleukin 11 receptor subunit alpha 1 JBrowse link 5 58,149,150 58,159,072 RGD:6907045
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6907045
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6907045
G Il12rb1 interleukin 12 receptor subunit beta 1 JBrowse link 16 20,370,722 20,383,576 RGD:6907045
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6907045
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6907045
G Il13ra1 interleukin 13 receptor subunit alpha 1 JBrowse link X 122,724,081 122,783,801 RGD:6907045
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6907045
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:5024920
RGD:6907045
G Il15ra interleukin 15 receptor subunit alpha JBrowse link 17 70,451,861 70,481,838 RGD:5001122
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6907045
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6907045
G Il20 interleukin 20 JBrowse link 13 47,644,071 47,651,487 RGD:6907045
G Il20ra interleukin 20 receptor subunit alpha JBrowse link 1 15,180,328 15,222,785 RGD:6907045
G Il20rb interleukin 20 receptor subunit beta JBrowse link 8 108,745,906 108,778,561 RGD:6907045
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:6907045
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6907045
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6907045
G Il22ra1 interleukin 22 receptor subunit alpha 1 JBrowse link 5 154,078,093 154,102,903 RGD:6907045
G Il22ra2 interleukin 22 receptor subunit alpha 2 JBrowse link 1 15,084,136 15,107,423 RGD:6907045
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6907045
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:6907045
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6907045
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:6907045
G Il2rb interleukin 2 receptor subunit beta JBrowse link 7 119,701,338 119,716,238 RGD:6907045
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6907045
G Il3 interleukin 3 JBrowse link 10 39,620,535 39,622,973 RGD:6907045
G Il3ra interleukin 3 receptor subunit alpha JBrowse link 12 18,534,762 18,542,508 RGD:6907045
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6907045
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6907045
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6907045
G Il5ra interleukin 5 receptor subunit alpha JBrowse link 4 138,796,165 138,834,164 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6907045
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:6907045
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:6907045
G Il7r interleukin 7 receptor RGD:6907045
G Il9 interleukin 9 JBrowse link 17 8,558,827 8,561,950 RGD:6907045
G Il9r interleukin 9 receptor JBrowse link 10 15,697,216 15,708,684 RGD:6907045
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128774
G Irf9 interferon regulatory factor 9 JBrowse link 15 34,282,936 34,288,981 RGD:6907045
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:1299183
RGD:6907045
RGD:1625126
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6907045
RGD:1625126
RGD:1624963
RGD:632386
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:729028
RGD:6907045
RGD:1625126
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6907045
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6907045
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:6907045
G Lifr LIF receptor alpha JBrowse link 2 56,424,910 56,489,346 RGD:6907045
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Mpl MPL proto-oncogene, thrombopoietin receptor JBrowse link 5 137,268,412 137,282,032 RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Osm oncostatin M JBrowse link 14 84,457,487 84,469,426 RGD:6907045
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:6907045
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:1357941
RGD:6907045
RGD:2290530
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:2290530
RGD:6907045
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:1357941
RGD:6907045
RGD:2290530
G Pias4 protein inhibitor of activated STAT, 4 JBrowse link 7 11,414,565 11,428,090 RGD:1357941
RGD:6907045
RGD:2290530
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6907045
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6907045
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:633057
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:2290530
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:2290530
RGD:6907045
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:2290530
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:2290530
RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1357935
RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:1357935
RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:1357935
RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:1357941
RGD:6907045
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1357941
RGD:6907045
G Socs6 suppressor of cytokine signaling 6 JBrowse link 18 85,962,729 85,981,125 RGD:1357941
G Socs7 suppressor of cytokine signaling 7 JBrowse link 10 85,301,797 85,337,971 RGD:1357941
RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Spred1 sprouty-related, EVH1 domain containing 1 JBrowse link 3 108,795,337 108,861,650 RGD:6907045
G Spred2 sprouty-related, EVH1 domain containing 2 JBrowse link 14 104,268,362 104,290,206 RGD:6907045
G Spred3 sprouty-related, EVH1 domain containing 3 JBrowse link 1 88,101,213 88,112,719 RGD:6907045
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:6907045
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:6907045
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:6907045
G Stam signal transducing adaptor molecule JBrowse link 17 81,209,795 81,256,111 RGD:6907045
G Stam2 signal transducing adaptor molecule 2 JBrowse link 3 38,230,676 38,277,433 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1299060
RGD:6907045
RGD:1625126
G Stat2 signal transducer and activator of transcription 2 JBrowse link 7 2,691,064 2,707,530 RGD:1357935
RGD:6907045
RGD:1625126
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:1299183
RGD:6907045
RGD:1625126
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:1357935
RGD:6907045
RGD:1625126
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1357935
RGD:6907045
RGD:1625126
RGD:1624963
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:628356
RGD:6907045
RGD:1625126
RGD:1624963
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:1357935
RGD:6907045
RGD:1625126
G Tpo thyroid peroxidase JBrowse link 6 49,020,918 49,089,855 RGD:6907045
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6907045
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:1357935
RGD:1625126
altered Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1357939
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1357939

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassJak membersJanus-activated kinase
Gene GroupStat target genesList of selected target genes
Functional ClassPiasproteins that inhibit activated STATs
Functional ClassStat memberssignal transducers and activators of transcription
Functional ClassSocs memberssuppressors of cytokine signaling
Functional Classphosphatasestyrosine phosphatases involved in the regulation of Jak-Stat pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Jak-Stat signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCsf2
abdominal obesity-metabolic syndromeCtf1 , Lep
abdominal obesity-metabolic syndrome 1Lep
Aberrant Crypt FociMyc
Abortion, SpontaneousCsf3 , Il11 , Il12b , Il20ra , Il24 , Il5ra , Il6 , Il9 , Jak2 , Lif , Prlr
achalasiaSpry2
achondroplasiaSpred2
acneIl4r
acquired immunodeficiency syndromeIfng , Il10 , Il2 , Il4r
acromegalyGh1
Acute Coronary SyndromeIl6
acute disseminated encephalomyelitisIfng
Acute Erythroblastic LeukemiaEpor
Acute ErythroleukemiaEpor
Acute HepatitisIl4
acute kidney failureBcl2l1 , Epo , Il10 , Il20 , Il6 , Myc
Acute Liver FailureCsf3 , Il6
Acute Lung InjuryIfng , Il10 , Il13 , Il2 , Il22 , Il4 , Il6 , Jak3
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesCrlf2 , Il7r , Jak1 , Jak2 , Jak3
acute myeloid leukemiaBcl2l1 , Cbl , Ccnd1 , Ccnd2 , Crebbp , Csf2 , Csf3 , Csf3r , Il10 , Il6 , Jak1 , Jak2 , Myc , Ptpn11 , Spry4 , Stat3
Acute Necrotizing PancreatitisIl6
acute promyelocytic leukemiaAkt1 , Ifng , Myc
acute retinal necrosis syndromeIfng
Acute-Phase ReactionEpo , Il6 , Il6r , Stat5b
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCcnd1 , Myc , Pik3ca , Prl , Ptpn11 , Stat3 , Stat5a
adenoid cystic carcinomaCcnd1 , Crebbp , Ep300 , Jak3 , Pik3ca , Stat3
adenomaBcl2l1 , Prl
adenosine deaminase deficiencyJak3
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adrenoleukodystrophyIfng
adult respiratory distress syndromeIl10 , Il15 , Il9 , Lep
adult T-cell leukemiaIfng , Il10 , Il2 , Il4 , Il5 , Il6 , Jak3 , Stat3
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
aggressive periodontitisIl2
agranulocytosisCsf2 , Csf3
AIDS Dementia ComplexEpo
Airway ObstructionIl10 , Il9
AlbuminuriaEpo , Il6 , Lepr , Tslp
Alcoholic Fatty LiverStat4
alcoholic hepatitisIl13
Alcoholic IntoxicationIfng
alcoholic liver cirrhosisIl6 , Jak2
allergic asthmaIl4r
allergic conjunctivitisIfng , Il10 , Il13 , Il4r , Irf1
allergic contact dermatitisCish , Ifng , Il10 , Il2 , Il2ra , Il4 , Il5 , Pim1 , Socs1 , Socs2
allergic cutaneous vasculitisCsf3
allergic hypersensitivity diseaseIfng , Il13 , Il2 , Il2rb , Il4 , Il5ra , Il6 , Il6st
allergic rhinitisIfng , Il10 , Il13 , Il13ra2 , Il2 , Il4 , Il5
Allergic RhinoconjunctivitisIl3
alopecia areataIl2 , Il2ra
alopecia universalisIl4
Alveolar Bone LossIl10
Alzheimer's diseaseAkt1 , Bcl2l1 , Crebbp , Ep300 , Epo , Epor , Il10 , Il2 , Il3 , Il4 , Il6 , Il6r , Il6st , Il7 , Jak2 , Lep , Pik3r1 , Stat3
amelanotic melanomaIfnb1
amenorrheaPrl
amnestic disorderCsf2 , Il2 , Il6
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Bcl2l1 , Cntf , Epo
amyotrophic lateral sclerosis type 1Bcl2l1 , Cntf , Crebbp , Jak3
AnaphylaxisIl4
anaplastic large cell lymphomaStat3
Anastomotic LeakEpo
anauxetic dysplasia 1Il11ra1
anemiaCsf2 , Csf3 , Epo , Epor , Gh1 , Il10 , Il2 , Il3 , Il6 , Jak2 , Prl
angiomyolipomaStat1 , Stat3
angiosarcomaCcnd1 , Csf3 , Myc , Stat3
angiostrongyliasisIl5
Animal Disease ModelsAkt1 , Csf3 , Ifng , Il10 , Myc , Pim1 , Stat3
Animal Mammary NeoplasmsCcnd1 , Il6st , Pik3r1 , Prl , Prlr , Stat3 , Stat5a
ankylosing spondylitisIl12b , Il23r , Il6 , Jak2
anogenital venereal wartIl12b , Il4
AnorexiaIl2
anterior ischemic optic neuropathyCsf3
anterior uveitisIfng
anti-basement membrane glomerulonephritisIl10 , Il4 , Ptk2b
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCsf3
anus benign neoplasmIfnb1
aortic valve disease 1Il6
aortic valve stenosisPtpn11
Aortic Valve, Calcification ofAkt1
aplastic anemiaCsf2 , Csf3 , Ifng
appendicitisIfng , Il10
arrhythmogenic right ventricular cardiomyopathyIl6r
Arsenic PoisoningPias1
arteriosclerosisIfngr1 , Il10 , Il15 , Il6st , Lepr
arteriovenous malformations of the brainIl6
ArthralgiaCsf3
arthritisIl23r
Ascorbic Acid DeficiencyIl6
aseptic meningitisIl6
aspergillosisIl15
Aspirin-Induced AsthmaIl4
AstheniaIl2
asthenopiaIl10
asthmaCsf2 , Csf2rb , Csf3 , Ifng , Ifngr1 , Ifnl3 , Il10 , Il12a , Il12b , Il13 , Il13ra1 , Il13ra2 , Il15 , Il19 , Il2 , Il21 , Il22 , Il23a , Il23r , Il2ra , Il2rb , Il3 , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il9 , Il9r , Irf1 , Lep , Stat4 , Stat6 , Tslp
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Ccnd1 , Ptpn11
ataxia telangiectasiaIfng , Il2 , Il6
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Ifng , Il2 , Il6 , Socs3 , Stat3
atopic dermatitisIfng , Ifnl3 , Il10 , Il13 , Il13ra1 , Il13ra2 , Il2 , Il21r , Il4 , Il4r , Il5 , Il6 , Stat6 , Tslp
atrial fibrillationIl2
atrial heart septal defectCrebbp
AtrophyStat3
attention deficit hyperactivity disorderCrebbp
Autism, Susceptibility to, X-Linked 6Spry3
autistic disorderCrebbp , Ghr , Ifng , Il10 , Il13 , Il15 , Il2 , Il4 , Il5 , Il6 , Lep , Prl , Prlr , Stat3
Autoimmune Disease, Multisystem, Infantile-Onset, 1Stat3
Autoimmune DiseasesIfng , Il2rb , Il4 , Il6 , Stat3 , Stat6 , Tpo
autoimmune hemolytic anemiaIl10 , Tslp
autoimmune hepatitisIfng , Il10 , Il13 , Il2 , Il22 , Il4 , Il5 , Il6 , Il9 , Lep
autoimmune polyendocrine syndrome type 1Gh1
autoimmune thrombocytopenic purpuraIl10 , Il2 , Il4
autoimmune thyroiditisIfng , Il4 , Il6
autosomal dominant polycystic kidney diseaseMyc , Stat6
autosomal recessive distal spinal muscular atrophy 2Cntfr , Il11ra1
autosomal recessive polycystic kidney diseaseAkt1 , Myc , Pik3ca
AzotemiaGh1
B-Cell Chronic Lymphocytic LeukemiaCbl , Ifng , Il10 , Il19 , Il6
B-Cell LeukemiaIl5 , Myc
B-cell lymphomaCsf2 , Csf3 , Il21r , Jak3 , Ptpn1
BacteremiaCish , Csf2
bacterial infectious diseaseIl10 , Il2
bacterial pneumoniaCsf3 , Csf3r , Ifnar1 , Il15 , Il22 , Irf1 , Lep , Stat3
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
basal cell carcinomaIl6 , Pik3ca
basal ganglia diseasePrl
BCG and Salmonella Infection, DisseminatedIl12b
BCG Infection, Generalized FamilialIfngr1
BCG Infection, Generalized Familial Semibenign, Autosomal DominantIfngr1
Behcet's diseaseIfng , Il10 , Il2 , Il21r , Il23r , Il4 , Il6 , Stat3 , Stat4
berylliosisIl2ra , Il6
beta thalassemiaEpo , Gh1 , Il6
Bile Duct NeoplasmsIl6
biliary tract benign neoplasmIl4 , Il6
bilirubin metabolic disorderCsf3
bipolar disorderAkt1
birdshot chorioretinopathyIl2
bladder urothelial carcinomaAkt1 , Crebbp , Ep300 , Pik3ca
Body Weight ChangesLep
Bone Marrow Failure SyndromesCsf2
Bone Marrow NeoplasmsCsf3
Bovine TuberculosisIl4
BradycardiaPrl
Brain ConcussionIl6
brain diseaseIfnb1 , Ifng
Brain HypoxiaEp300 , Epo , Epor
brain infarctionIl15
Brain InjuriesAkt1 , Csf2 , Csf3 , Epo , Epor , Ifnl3 , Il10 , Il12rb2 , Il13ra2 , Il2 , Il3 , Il4 , Il5 , Il6 , Il7 , Il9r , Irf1 , Jak2 , Lep , Pias1 , Stat1 , Stat3
brain ischemiaAkt1 , Bcl2l1 , Csf2rb , Csf3 , Epor , Il10rb , Il12rb1 , Il6 , Il6st , Lif , Ptk2b , Stat3
Brain NeoplasmsCcnd1 , Il2 , Pik3ca , Pik3r1 , Ptpn11
branched-chain keto acid dehydrogenase kinase deficiencyCtf1
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Grb2 , Myc , Pik3ca , Stat1
Breast Cancer, FamilialPik3ca , Pik3r3
Breast NeoplasmsAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Csf2 , Csf3 , Ep300 , Epo , Epor , Ghr , Ifnb1 , Ifng , Il13 , Il13ra2 , Il24 , Il6 , Lep , Lepr , Myc , Pik3ca , Pik3r1 , Pim1 , Ptk2b , Socs1 , Socs2 , Stat1 , Stat3 , Stat5a
Bronchial HyperreactivityIfng , Il10 , Il13 , Il15 , Il21r , Il4r , Il5
bronchiectasisStat1
bronchiolitis obliteransCsf2 , Ifng , Il13 , Il13ra1 , Il13ra2 , Il4 , Il6
bronchiolo-alveolar adenocarcinomaCcnd1
bronchitisIfng
Bronchitis, ChronicIl10 , Il13 , Il15
bronchus carcinomaIl10
Bruton-type agammaglobulinemiaPik3r1
Budd-Chiari syndromeJak2
bullous pemphigoidIl2
Burkitt lymphomaMyc , Pik3r1
BurnsCcnd1 , Il10 , Il6 , Socs3
Burns, ChemicalIl6
CachexiaIl6
Cadmium PoisoningIl6
Cafe au lait Spots, MultipleSos1
Cafe-au-Lait SpotsSpred1
CAKUTLifr
calcinosisEpo , Jak2 , Ptpn6
cancerMyc , Pik3ca , Pik3r1
Candidiasis, Familial, 6Stat1
cannabis abuseAkt1
capillary hemangiomaAkt3
carcinomaBcl2l1 , Ccnd1 , Csf2 , Csf3 , Il6st , Myc , Pik3r1 , Prlr , Stat3 , Stat5a
Carcinoma, Lewis LungIl2
cardiac arrestAkt1 , Ep300 , Ifng
Cardiac FibrosisCsf3
cardiofaciocutaneous syndromePtpn11
Cardiogenic ShockEpo
CardiomegalyAkt1 , Ccnd2 , Ctf1 , Ep300 , Il6 , Il6st , Lif , Myc , Stat3
cardiomyopathyAkt1 , Ep300 , Epo , Ifng , Il4 , Il6 , Stat3
Cardiovascular AbnormalitiesPtpn11
cardiovascular system diseaseGh1
Cardiovirus InfectionsIfnar1
carotid artery diseaseIl10 , Prl
Carotid Artery InjuriesCbl , Csf3 , Myc
carotid stenosisIl10 , Il4
Castleman diseaseIl6
CatalepsyPrl
cataractIfng
Cd4+ Lymphocyte DeficiencyJak3
Cecal NeoplasmsCcnd1
celiac diseaseIl15 , Il21 , Il23r , Il6
Cell Transformation, NeoplasticCcnd1 , Il6 , Il7r , Myc , Pim1 , Stat3
central nervous system diseaseCrebbp , Epo , Il6
central nervous system lymphomaIl10
Cerebral HemorrhageBcl2l1 , Cntf , Csf3
cerebral malariaJak3
cervix uteri carcinoma in situCcnd1 , Stat3
Chagas CardiomyopathyIl10
Chagas diseaseIfng
Charcot-Marie-Tooth disease dominant intermediate CCsf3r , Mpl , Pik3r3
Chemical and Drug Induced Liver InjuryCsf3 , Ifng , Il11 , Il22 , Il4 , Il6
ChillsIfng
chlamydiaIfng , Il13
ChloracneOsm
cholangiocarcinomaEpo , Epor , Il4r , Il6
cholestasisGhr , Il4 , Il6
cholesteatomaStat4
cholesteatoma of middle earIl2 , Il6
chorioamnionitisIl6
choroid diseaseIl10
Choroidal NeovascularizationIl10 , Il2 , Lep , Stat3
choroiditisIfng
Chromosome 13q Deletion SyndromeSpry2
chromosome 13q14 deletion syndromeSpry2
Chromosome BreakageIl4 , Myc
chronic granulomatous diseaseIfng
Chronic HepatitisStat3
chronic kidney diseaseIl19
chronic lymphocytic leukemiaIl5 , Myc , Ptpn11
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaAkt1 , Bcl2l1 , Csf3r , Il10 , Jak2
chronic myelomonocytic leukemiaCsf3r
chronic neutrophilic leukemiaCsf3r
chronic obstructive pulmonary diseaseBcl2l1 , Csf2 , Il12b , Il13 , Il13ra1 , Il5 , Il5ra , Il6 , Il9 , Lep , Lepr , Stat4
Chronic PancreatitisIfng
Churg-Strauss syndromeIl5 , Stat3
clear cell renal cell carcinomaEp300 , Myc
cleft lipMyc , Spry2
cleft palateMyc , Spry2
CLOVES syndromePik3ca
Cocaine-Related DisordersPrl , Tyk2
cochlear diseaseIl6
Cockayne syndromeGhr
cognitive disorderCsf3 , Epo , Il4
Cognitive DysfunctionStat1
cold-induced sweating syndromeClcf1
cold-induced sweating syndrome 2Clcf1
colitisIfng , Il10 , Il4 , Il5 , Il6
colon adenocarcinomaCsf2 , Pik3r3
colon cancerAkt1 , Pik3ca
colon carcinomaAkt1 , Ep300 , Pik3ca
colonic diseaseGhr
Colonic NeoplasmsAkt2 , Akt3 , Ccnd1 , Ccnd2 , Ifng , Jak3 , Lep , Myc , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Stat3
Colonic PolypsGhr
colorectal adenocarcinomaBcl2l1
colorectal cancerAkt1 , Ep300 , Pik3ca , Stat3
Colorectal NeoplasmsAkt1 , Akt2 , Ccnd1 , Crebbp , Csf2 , Ep300 , Il6st , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Ptpn11
combined T cell and B cell immunodeficiencyIl2rg
common coldIl10 , Il4
common variable immunodeficiencyIl21 , Il21r
Common Variable Immunodeficiency 11Il21
complex cortical dysplasia with other brain malformationsAkt3 , Pik3ca
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital amegakaryocytic thrombocytopeniaMpl
congenital diaphragmatic herniaCbl , Ep300 , Epo , Pim1 , Stat3
congenital heart diseasePtpn11
Congenital Hepatic FibrosisIfnl3
congenital hypothyroidismGh1 , Ghr , Tpo
congestive heart failureCbl , Csf2 , Csf3 , Ep300 , Epo , Ifng , Il10 , Il6 , Il6r , Lep , Lepr , Lif , Prl
conjunctival diseaseIl6
contact dermatitisIl13 , Il4 , Osm
Copper-Overload CirrhosisStat3
Corneal PerforationIfng
corneal ulcerIl6
coronary artery diseaseAkt1 , Epo , Il10 , Il15 , Il6
coronary restenosisMyc
Coronavirus InfectionsIl6
Costello syndromePtpn11
CoughCsf2 , Il5
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
Coxsackievirus InfectionsIl6
Craniofacial AbnormalitiesEp300 , Spry2
Craniosynostosis and Dental AnomaliesIl11ra1
crescentic glomerulonephritisStat6
Crohn's diseaseIfng , Il10 , Il12b , Il21r , Il23r , Il2ra , Il6 , Jak2 , Lep , Ptpn2 , Stat3 , Tyk2
cryoglobulinemiaIfnl3 , Tslp
cryptococcosisIl4r
cryptorchidismBcl2l1 , Cbl
Currarino TriadPik3ca
cutaneous leishmaniasisIfng , Il10 , Il13 , Il4 , Stat4
cutaneous T cell lymphomaIl4 , Stat5b
cystic fibrosisCsf3r , Il13 , Il6 , Il9 , Il9r , Irf1 , Lep
cystitisCsf3 , Il11 , Il2 , Il4
Cytomegalovirus InfectionsIl5 , Stat1
cytomegalovirus retinitisIl10
decubitus ulcerIl10
Delayed HypersensitivityIfng , Il13
Delayed PubertyLepr
Dementia, Multi-InfarctIl2
demyelinating diseaseMyc
Dermal FibrosisStat4
dermatitisIl13
dermatomyositisIfng , Il4 , Stat4
Developmental DisabilitiesAkt3 , Cbl , Crebbp , Ep300 , Pik3r2 , Tpo
diabetes insipidusGh1
diabetes mellitusGh1 , Il10 , Il2ra , Il6 , Lep , Lepr
Diabetes Mellitus, Experimental Akt1 , Bcl2l1 , Ccnd3 , Ep300 , Epo , Epor , Gh1 , Ghr , Ifnar1 , Ifng , Il10 , Il2 , Il2ra , Il4 , Il4r , Il6 , Jak3 , Lep , Lepr , Myc , Pik3r1 , Socs3 , Stat1 , Stat3 , Stat4 , Stat5b
diabetic angiopathyPtk2b
Diabetic CardiomyopathiesIl10
Diabetic FootIl15
Diabetic NephropathiesEp300 , Epo , Ghr , Ifng , Il10 , Il6 , Jak2 , Lep , Stat3
diabetic neuropathyEpo , Ifng , Lepr
diabetic retinopathyEp300 , Epo , Gh1 , Il10 , Il6
Diamond-Blackfan anemiaGh1
DIAMOND-BLACKFAN ANEMIA-LIKEEpo
Diaphragmatic HerniaIl6
diarrheaCsf3
diffuse large B-cell lymphomaIl21r , Pik3ca , Pik3cb , Pik3cd
diffuse sclerodermaIl10 , Il6 , Stat4
dilated cardiomyopathyBcl2l1 , Csf3 , Ctf1 , Il10 , Il13ra2 , Lepr , Ptpn11
disease by infectious agentStat1
disease of cellular proliferationCsf2 , Ifng , Il2 , Il3 , Myc , Pik3ca , Pik3r1
disease of metabolismPtpn11
Disease ProgressionMyc , Pik3ca , Stat1
Disease SusceptibilityCsf3
disseminated intravascular coagulationIl10 , Il6
drug allergyIl10 , Il13 , Il2 , Il4 , Il4r
Drug EruptionsIl4
Drug-Induced AgranulocytosisCsf3
Drug-induced AnemiaIfnl3
Drug-induced NeutropeniaCsf3
Drug-Related Side Effects and Adverse ReactionsCsf2 , Csf3 , Il3
dry eye syndromeIfng , Il10 , Il6
Ductal CarcinomaStat5a
ductal carcinoma in situCcnd1 , Ccnd2 , Socs1 , Socs2 , Socs3 , Stat5a
duodenal ulcerStat3
DwarfismGh1 , Ghr
DyslipidemiasLepr
Eales DiseaseIl10 , Il6
Ebola hemorrhagic feverIl3
echinococcosisIl5
eclampsiaIl6
EczemaIfngr1 , Il13 , Il4r , Stat4
eczema herpeticumIfng
EdemaIl11 , Il4 , Il6 , Jak3 , Stat6
egg allergyIl13
Embryo LossLif
embryonal rhabdomyosarcomaPtpn11
end stage renal failureEpo , Epor , Il20 , Il6 , Lep
endometrial adenocarcinomaPik3r1
endometrial cancerPik3cb , Pik3r1
endometrial carcinomaPik3ca , Pik3r1
Endometrial NeoplasmsAkt2 , Bcl2l1 , Ccnd1 , Ep300 , Grb2 , Il10 , Irf1 , Myc , Pik3ca , Pik3cb , Pik3cd , Socs2 , Socs3 , Stat3
Endometrioid CarcinomasAkt1 , Pik3r2
endometriosisBcl2l1 , Ifngr1 , Il10 , Il15 , Il7r , Prl , Prlr
endophthalmitisIfng
EndotoxemiaCsf3 , Ep300 , Epo , Ghr , Ifng , Il10 , Il13 , Il6 , Socs1 , Socs3 , Stat5b
EntamoebiasisIfng , Il10 , Il2 , Il5 , Il6
Enterobacteriaceae InfectionsCsf3
EnterocolitisIl10
EosinophiliaIl5 , Il5ra
Eosinophilic EnteropathyIl5
eosinophilic esophagitisIl5 , Tslp
EpendymomaSpry3
Epidermal HyperplasiaStat3
epidermal nevusPik3ca
epididymitisIl6
epilepsyAkt1 , Il6
esophageal carcinomaEp300 , Myc , Pik3ca
Esophageal NeoplasmsCcnd1 , Csf3 , Il5 , Myc
esophagitisIl13 , Il4r
esophagus adenocarcinomaPik3ca
essential thrombocythemiaJak2 , Mpl , Tpo
Experimental ArthritisAkt1 , Cbl , Cblb , Csf3 , Ifng , Il10 , Il13 , Il15 , Il2 , Il20 , Il2ra , Il4 , Il6 , Il6st , Jak2 , Jak3 , Lep , Pik3cd , Socs3 , Stat1 , Stat3
Experimental Autoimmune EncephalomyelitisCblb , Epo , Ifng , Il10 , Il10ra , Il12a , Il12b , Il13 , Il21 , Il21r , Il22 , Il2ra , Il4 , Il6 , Jak2 , Jak3 , Stat1 , Stat3 , Stat4
Experimental Autoimmune Myasthenia GravisIl15 , Il23r , Il2ra , Il4r
Experimental Autoimmune MyocarditisIl13 , Il6
Experimental Autoimmune NeuritisEpo , Il5
Experimental Autoimmune UveitisIl10 , Stat3
Experimental Autoimmune UveoretinitisIfng , Il10 , Il2 , Il4 , Stat3
Experimental ColitisCsf3 , Ifng , Il10 , Il2 , Il6
Experimental LeukemiaCbl
Experimental Liver CirrhosisCsf3 , Gh1 , Ghr , Ifng , Ifngr1 , Il10 , Il2rb , Il2rg , Il6 , Il7r , Jak2 , Lep , Lepr , Myc , Osm , Prlr , Ptpn1 , Socs1 , Socs2
Experimental Liver NeoplasmsBcl2l1 , Ccnd1 , Il6 , Jak2 , Myc , Socs1 , Stat3
Experimental MelanomaIfnb1 , Il2
Experimental NeoplasmsCcnd1 , Ifnb1 , Ifng , Il12a , Il12b , Il2
Experimental SarcomaEpo , Ifng
extrahepatic cholestasisIl6
extrinsic allergic alveolitisIl13 , Il5
Eye BurnsIl10
eyelid diseaseCsf2 , Ifng
Facial AsymmetryPik3ca
factor VIII deficiencyIfng , Il10
Failure to ThrivePtpn11 , Stat1
familial adenomatous polyposisAkt1
familial erythrocytosis 1Epor , Jak2
familial erythrocytosis 2Jak2
familial erythrocytosis 5Epo
Familial ErythroleukemiaEpor
familial hypercholesterolemiaGhr
familial hyperlipidemiaLep , Lepr
familial hypertrophic cardiomyopathyCtf1 , Sos1
familial Mediterranean feverIl6
familial medullary thyroid carcinomaPrlr
Familial MyelofibrosisMpl
familial partial lipodystrophyAkt2
Fanconi anemiaIfng , Il10
farmer's lungIl12b
FatigueEpo
fatty liver diseaseIl10 , Il13ra2 , Il6 , Jak2 , Lep , Lepr , Myc , Socs1 , Socs3
Female InfertilityLep , Lepr , Lif , Prl
Female Urogenital DiseasesLif
Femoral FracturesCsf2 , Il10 , Il2 , Il6 , Lep
Fetal DistressEpo , Epor
Fetal Growth RetardationLep , Ptpn11
Fetal Inflammatory Response SyndromeIl6
Fetal ResorptionPrl
FeverCsf3 , Ifng , Il2 , Il6 , Il6r , Prl , Stat3
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Ccnd2 , Csf3 , Il13 , Il4 , Lepr , Socs3 , Stat3 , Stat6
focal segmental glomerulosclerosisPias1
follicular lymphomaCrebbp
food allergyIfnl3 , Il13 , Il5
Foot InjuriesIl6
Fungal Lung DiseasesIl13
GalactorrheaPrl
galactosemiaIl11ra1
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsIl10 , Il4r
gastric adenocarcinomaAkt1 , Crebbp , Irf1 , Pik3ca , Ptpn11
gastric ulcerBcl2l1 , Epo , Lep
Gastro-Enteropancreatic Neuroendocrine TumorIl10 , Il2rb
Gastrointestinal DiseasesCsf3
Gastrointestinal HemorrhageCsf2
Gastrointestinal NeoplasmsPik3ca
Gaucher's diseaseIl4
genetic diseaseAkt2 , Akt3 , Cbl , Ccnd2 , Crebbp , Ep300 , Il10rb , Il21r , Il2rg , Jak1 , Pik3ca , Pik3r1 , Pik3r2 , Ptpn11 , Sos1 , Spred1 , Stat1 , Stat2 , Stat3
Genetic Predisposition to DiseaseIl10
genital herpesIfng , Il3 , Stat4
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsCcnd2
germinomaCcnd2
gestational diabetesGh1 , Il10 , Il6 , Lep , Lepr
gingival fibromatosisSos1
gingivitisIl6
glaucomaCcnd2 , Cntf , Crebbp , Epo , Epor
glioblastoma multiformeAkt1 , Akt3 , Crebbp , Il2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pim1
GliosisLepr
glomerulonephritisEp300 , Ifng , Il10 , Il2 , Il2ra , Il6 , Ptk2b , Tpo
glucose intoleranceJak2 , Lep , Lepr
glucosephosphate dehydrogenase deficiencyIfng , Il10 , Il6
goiterTpo
Graft vs Host DiseaseIfng , Il10 , Il10rb , Il2 , Il21r , Jak3
GranulomaIl4
Granuloma, Respiratory TractIl13
granulomatosis with polyangiitisIl10
granulosa cell tumorCcnd2 , Lepr
Graves OphthalmopathyIfng , Il10 , Il2 , Il23r , Il3
Graves' diseaseIfng , Il10 , Il13 , Il2 , Il23r , Il3 , Il6 , Il6r , Stat4 , Stat6
Growth DisordersCbl , Gh1 , Jak2 , Pik3ca
growth hormone secreting pituitary adenomaGh1 , Prl , Ptpn11
gynecomastiaPrl
Hashimoto DiseaseIfng , Il6
Head and Neck NeoplasmsBcl2l1 , Csf3 , Pik3ca , Stat6
head and neck squamous cell carcinomaAkt1 , Ccnd1 , Crebbp , Ep300 , Il2 , Pik3ca , Stat3
HeadacheCsf3 , Il6
Hearing LossBcl2l1 , Il10 , Stat1
Hearing Loss, Noise-InducedIl6
Hearing Loss, SuddenIl4r , Il6
heart diseaseCsf3 , Ep300 , Epo , Jak2 , Stat3
heart valve diseaseJak2 , Ptpn6
Heat Stress DisordersIl6
Heat StrokeIl10 , Il11ra1 , Il6 , Il6r
Helicobacter InfectionsIfngr1 , Socs3
hemarthrosisIl6
Hematologic NeoplasmsCbl , Mpl
Hematoma, Subdural, AcuteEpo
hematopoietic system diseaseBcl2l1
HemimegalencephalyPik3ca
hemolytic anemiaEpo
hemolytic-uremic syndromeEpo , Il6
HemorrhageIl11
hemorrhagic fever with renal syndromeIfng , Il2ra
Henoch-Schoenlein purpuraIl5
Heparin-induced ThrombocytopeniaIl10
hepatic encephalopathyEpor
hepatic veno-occlusive diseaseCsf3
hepatitisIfng
hepatitis BIfnb1 , Ifng , Ifngr1 , Il10rb
hepatitis CIfnar1 , Ifng , Ifnl3 , Il10
Hepatitis C, ChronicIfnl3 , Stat3
hepatocellular adenomaPtpn11
hepatocellular carcinomaAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Crebbp , Csf2 , Ep300 , Il10 , Il2 , Il6 , Il6st , Myc , Pik3ca , Socs3 , Stat1 , Stat4
HepatomegalyLepr
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesCsf2 , Il13 , Il3 , Il4 , Il5 , Il9 , Irf1 , Pik3ca , Spry4 , Tslp
hereditary neutrophiliaCsf3r
heroin dependenceLep
Herpes Simplex EncephalitisStat4
herpes simplex virus keratitisIfng , Il10 , Stat4
herpes zosterIl10 , Il2 , Il4
Hirschsprung Disease 1Crebbp
HirsutismEp300
HIV Wasting SyndromeIl6
Hodgkin's lymphomaCsf3 , Il10 , Il6 , Ptpn1
human immunodeficiency virus infectious diseaseIfng , Il10 , Il15 , Il2 , Il21r , Il2ra , Il4r , Il6 , Socs1 , Socs3
Human InfluenzaCsf2 , Il10 , Il12b , Il13 , Il15 , Il15ra , Il2 , Il22 , Il4 , Il6 , Stat1
Huntington's diseaseCntf , Crebbp , Ep300 , Il6 , Il6r , Lep
hydrocephalusCcnd2
Hydrops FetalisJak3
Hyper-IgE Recurrent Infection Syndrome, Autosomal DominantIl4r , Stat3
HyperalgesiaCsf3 , Ep300 , Il10 , Il13 , Il2 , Il6 , Il6r , Jak2 , Jak3 , Stat3
hyperandrogenismIl6st
hypercalcemiaIl6
HypercapniaLep
HypercholesterolemiaCtf1 , Lep
hyperglycemiaCbl , Cntf , Il6 , Lepr
hyperinsulinismIl6 , Lep , Lepr , Ptpn1
HyperkinesisIl2
HyperoxaluriaIl6
HyperoxiaIl6
HyperparathyroidismCcnd1 , Myc
HyperphagiaLep , Lepr
Hyperphosphatasia with Mental Retardation Syndrome 2Cntfr , Il11ra1
HyperplasiaAkt1 , Ccnd1 , Il13 , Il9 , Lep , Pik3ca
hyperprolactinemiaPrl , Prlr
hypersensitivity reaction type III diseaseIfng
hypertensionAkt1 , Akt2 , Ctf1 , Ep300 , Epo , Epor , Il10 , Il6 , Il6r , Il6st , Lep , Lepr , Pik3r1 , Ptk2b , Ptpn1
hyperthyroidismIl10
HypertriglyceridemiaIl6st , Lep , Socs1 , Socs3
hypertrophic cardiomyopathyMyc , Ptpn11
HypertrophyCsf3
hyperuricemiaJak2 , Stat3
HypoalbuminemiaGh1 , Il6
hypoglycemiaAkt2 , Epo , Pik3r1 , Prl
hypogonadismIl6 , Lep , Lepr , Prl
hypogonadotropic hypogonadism 17 with or without anosmiaSpry4
hypogonadotropic hypogonadism 7 with or without anosmiaSpry4
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HyponatremiaIfng
hypopituitarismPrl
HypoproteinemiaGh1
HypotensionCtf1 , Ifng , Il2 , Il6 , Prl
HypothermiaIl12a , Il12b
hypothyroidismIl10 , Stat1
HypoventilationLep
HypoxiaIl4r , Stat5b
Hypoxia-Ischemia, BrainBcl2l1 , Epo , Ghr , Il6
ichthyosisIl2rb
idiopathic interstitial pneumoniaIl6
idiopathic pulmonary fibrosisIl2ra , Stat3
IgA glomerulonephritisSpry2 , Stat4
Ige Responsiveness, AtopicIl21r , Il4r
IL21R ImmunodeficiencyIl21r
ileitisIl10
Immediate HypersensitivityIl10 , Il13 , Il4 , Il4r
Immune Deficiency DiseaseIl2rg
Immunodeficiency 14Pik3cd
Immunodeficiency 27BIfngr1
IMMUNODEFICIENCY 28Ifnar1 , Ifngr2 , Il10rb
IMMUNODEFICIENCY 29Il12b
Immunodeficiency 30Il12rb1
Immunodeficiency 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency 36Pik3r1
Immunodeficiency 44Stat2
impotenceAkt1 , Bcl2l1 , Ccnd1 , Ccnd2 , Il6 , Prl
in situ carcinomaAkt1
InfarctionCsf3 , Prl
infertilityLepr
InflammationAkt1 , Csf2 , Epo , Ifng , Ifnl3 , Il10 , Il13 , Il15 , Il6 , Jak2 , Lep , Ptpn1 , Stat3 , Tslp
inflammatory bowel diseaseIl10 , Il10ra , Il10rb , Il2 , Il21r , Il23r , Il2ra , Il5 , Il6 , Stat3
inflammatory bowel disease 17Il23r
inflammatory bowel disease 25Il10rb
inflammatory bowel disease 28Il10ra
inherited metabolic disorderLepr
Insulin ResistanceAkt2 , Cblb , Cntf , Ctf1 , Gh1 , Il6 , Il6r , Lep , Lepr , Pik3r1 , Prl , Ptk2b , Ptpn1 , Socs1 , Socs3
intellectual disabilityEp300 , Tpo
Interferon Gamma, Receptor 1, DeficiencyIfngr1 , Ifngr2
Interleukin 2 Receptor, Alpha, Deficiency ofIl2ra
intermediate coronary syndromeAkt1
intermediate uveitisIl10
interstitial cystitisCsf2
interstitial lung diseaseIl2 , Il4r
Intervertebral Disc DisplacementAkt1
intestinal obstructionIl10
Intestinal PolypsCcnd1
Intestinal Reperfusion InjuryCsf3 , Il6 , Jak2
intracranial aneurysmIl6
Intracranial HemorrhagesIl6
Intraventricular HemorrhageIl6
invasive ductal carcinomaAkt1 , Ccnd3 , Il13 , Socs1 , Socs2 , Socs3
invasive lobular carcinomaCcnd1 , Ccnd2 , Stat5a
iron deficiency anemiaIl6
irritable bowel syndromeIl10
irritant dermatitisIl4 , Stat3
ischemiaAkt2 , Il6
isolated growth hormone deficiencyGh1 , Ghr
isolated growth hormone deficiency type IAGh1
isolated growth hormone deficiency type IBGh1
isolated growth hormone deficiency type IIGh1
janus kinase-3 deficiencyJak3
Job's syndromeIfng , Stat3
juvenile myelomonocytic leukemiaCbl , Csf2 , Jak3 , Ptpn11
juvenile rheumatoid arthritisIl2 , Il6 , Osm , Stat3
Kaposi's sarcomaIl6
Kawasaki diseaseIl13 , Il4
keratitisIl6
keratoconjunctivitis siccaIl6
keratoconusCntf
Kidney CalculiIfng
kidney diseaseCsf3 , Ctf1 , Epo , Lepr
kidney failureEpo , Ifng
Kidney NeoplasmsAkt1 , Ccnd1 , Il2
Kidney Reperfusion InjuryEp300 , Epo , Il10 , Lep , Myc , Stat6
Klebsiella InfectionsIl6
Knee OsteoarthritisEpo , Il2 , Il4 , Lep , Lepr
Kowarski SyndromeGh1
Kuhnt-Junius degenerationIl6
L-2-hydroxyglutaric aciduriaSos2
Language Development DisordersStat1 , Tpo
Laron syndromeGhr
Laron Syndrome Type 2Stat5b
Lead Poisoning, Nervous SystemEp300
learning disabilityGhr , Il6
Left Ventricular HypertrophyCtf1 , Lepr , Lifr , Myc , Ptk2b
Legionnaires' diseaseIfng
Legius SyndromeSpred1
leiomyomaBcl2l1 , Myc
leiomyosarcomaCsf3
leishmaniasisIfng , Il10 , Il2 , Il4 , Il6
LEOPARD syndromePtpn11
leprosyIl23r
LEPTIN DEFICIENCY OR DYSFUNCTIONLep
Leptin Receptor DeficiencyLepr
leukemiaCcnd1 , Il2 , Jak2 , Ptpn11
Leukemia, Prolymphocytic, T-CellJak3
Leukemoid ReactionJak3
LeukocytosisCsf3 , Csf3r
leukopeniaCsf3 , Il2 , Il3
Leydig cell tumorPrl
lichen diseaseIl6
lichen planusIfng
Limb IschemiaCsf2 , Csf3 , Epo
limited sclerodermaIl2 , Jak2 , Stat4
lipoid nephrosisIl13 , Stat6
liposarcomaIl22
listeriosisIl15
Liver AbscessStat1
liver benign neoplasmCcnd1 , Csf2 , Csf3 , Il10 , Il12a , Il12b , Il2 , Myc , Stat3
liver cancerAkt1 , Crebbp , Pik3ca
liver cirrhosisIfng , Ifnl3 , Il6 , Stat1 , Stat3
liver diseaseBcl2l1 , Csf3 , Il11 , Il9r , Socs1 , Socs3
Liver InjuryCsf3 , Il6 , Jak2 , Myc , Stat3
Liver Reperfusion InjuryBcl2l1 , Il10 , Il6 , Jak2
localized sclerodermaCsf3 , Il13
lung adenocarcinomaAkt1 , Ccnd1 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1
lung cancerIrf1 , Pik3ca
lung diseaseCsf3 , Il10 , Il13 , Il15 , Il4r , Il6 , Il9 , Irf1 , Lep , Spry2
Lung InjuryCsf3 , Il6
Lung NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ifng , Il10 , Il2 , Il24 , Il6 , Irf1 , Myc , Pik3ca , Spry2 , Stat5a
Lung Reperfusion InjuryIl4 , Myc
lung small cell carcinomaAkt1 , Ccnd1 , Crebbp , Csf3 , Ep300 , Myc , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Ccnd1 , Crebbp , Ep300 , Pik3ca , Ptpn11
lupus nephritisIfng , Stat4 , Stat6
lymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisIl13 , Pik3ca , Pik3cb , Socs2 , Socs3 , Stat3
lymphocytic choriomeningitisIl21r
lymphocytic leukemiaBcl2l1
lymphomaPtpn11
Lymphoma, AIDS-RelatedCsf2 , Csf3
Lymphoma, Extranodal NK-T-CellJak3
lymphopeniaCbl , Il2ra , Il7 , Jak3
lymphoproliferative syndromeIfng , Stat3
MacrocephalyAkt3 , Ccnd2
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular retinal edemaEpo , Il6
major depressive disorderIl2 , Il3 , Il5
malariaCish , Ifng
male infertilityCbl
malignant gliomaAkt2 , Ccnd1 , Epo , Epor , Ifng , Il10 , Il12a , Il12b , Il2 , Il4 , Il7 , Pik3ca , Pik3r3
malignant mesotheliomaIfng , Il12b , Il2ra , Il3 , Il4 , Il6 , Osmr
malignant ovarian germ cell neoplasmCbl
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd3 , Epo , Epor , Gh1 , Il10 , Il6st , Lep , Myc , Pik3r1 , Prl , Prlr , Socs1 , Socs3 , Stat1 , Stat3 , Stat5a , Stat6
Manganese PoisoningIfng
mantle cell lymphomaCcnd1 , Pik3cd
mastocytosisIl13 , Il4r , Il5ra
Mediastinal NeoplasmsJak3 , Ptpn1
medulloblastomaCcnd1 , Crebbp , Ep300 , Ifng , Mpl , Myc , Pik3ca , Stat3
megakaryocytic leukemiaJak3
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Ccnd2 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3Ccnd2
melanomaAkt1 , Bcl2l1 , Cbl , Crebbp , Csf2 , Csf3 , Ep300 , Epo , Epor , Ifnb1 , Ifng , Il2 , Myc , Pik3ca , Pik3r1 , Ptk2b , Tpo
membranoproliferative glomerulonephritisEp300 , Tslp
Memory DisordersStat3
Meningeal NeoplasmsAkt1
Meningeal TuberculosisIl4r
meningiomaAkt1
mental depressionBcl2l1 , Csf3 , Il6 , Il6r
Merkel cell carcinomaMyc
mesenteric vascular occlusionJak2
MesotheliomaIfng
Metabolic Bone DiseasesIl7
Metabolic SyndromeIl6 , Il6r , Lep , Prl
MetachondromatosisPtpn11
MetaplasiaIl13
microcephalyEp300
MicrognathismEp300
Microvascular Complications of Diabetes, Susceptibility to, 2Epo
Microvascular Complications of Diabetes, Susceptibility to, 3Epo
Microvascular Complications of Diabetes, Susceptibility to, 7Epo
middle cerebral artery infarctionCsf3 , Epo , Il11 , Il13 , Il22 , Il4 , Il5 , Il6 , Il6r , Il6st , Stat3
milk allergyIl13
mitochondrial myopathyIl6
mitral valve stenosisIl10
mixed connective tissue diseaseIfng
morbid obesityLep , Lepr
Mouth NeoplasmsPik3ca
mucocutaneous leishmaniasisIfng
mucositisCsf2 , Csf3 , Il10
Multiple AbnormalitiesCrebbp , Ep300 , Pik3r2 , Stat2
Multiple Fibroadenomas of the BreastPrlr
Multiple Hamartoma SyndromePik3ca
multiple myelomaBcl2l1 , Cbl , Ccnd1 , Ccnd2 , Ccnd3 , Csf2 , Csf3 , Il10 , Il4r , Il6 , Pik3ca , Ptpn11
Multiple Organ FailureIl10
multiple sclerosisCblb , Cntf , Ifnb1 , Ifng , Il10 , Il12a , Il13 , Il21r , Il23r , Il2ra , Il4 , Il4r , Il6 , Il7 , Il7r , Stat4 , Tyk2
Multisystem Autoimmune Disease, Infantile-OnsetStat3
Murine Acquired Immunodeficiency SyndromeIl10
Muscle HypotoniaEp300 , Jak3
Muscle SpasticityCrebbp
Muscle WeaknessCsf2 , Csf3
muscular atrophyAkt1 , Gh1 , Ghr
muscular diseaseCsf3
myasthenia gravisIl2rb
Mycobacterium InfectionsIfng , Ifngr1 , Il22 , Stat1
Mycobacterium Tuberculosis, Susceptibility To Infection ByCish , Ifng , Ifngr1 , Il12rb1
Mycoplasma pneumoniae pneumoniaIfng , Il13
myelodysplastic syndromeCrebbp , Csf3r , Epo , Myc
myelofibrosisJak2 , Mpl
myeloid leukemiaCsf3 , Ifng , Mpl
myeloid neoplasmCbl , Jak2
myeloproliferative neoplasmCsf3r , Jak2 , Jak3 , Mpl
myocardial infarctionAkt1 , Bcl2l1 , Csf2 , Csf3 , Epo , Epor , Gh1 , Il10 , Il4r , Il6 , Il6r , Jak2 , Socs1
Myocardial IschemiaCcnd1 , Ccnd2 , Ghr , Ifngr1 , Il6 , Il6st , Irf1 , Jak2 , Lepr , Socs3 , Stat5a
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bcl2l1 , Cbl , Il10 , Il6 , Il6r , Jak2 , Lep , Lepr , Stat1 , Stat3
myocarditisIl10 , Il21r , Il22 , Il6 , Stat6
Myoclonus, Familial CorticalMyc
myopiaEp300
narcolepsySocs2
Nasal PolypsIfng , Il10 , Il13 , Il5ra , Il9 , Lepr , Stat3
Nasopharyngeal NeoplasmsCcnd1 , Pik3ca
NauseaIfng
NecrosisCtf1 , Epo , Ifng , Il6
Nematode InfectionsIl4 , Pik3r1
NeointimaPtk2b , Stat4
Neoplasm InvasivenessEpo , Epor , Il6
Neoplasm MetastasisAkt2 , Ccnd1 , Ccnd2 , Csf3 , Epo , Epor , Il10 , Il2 , Il6 , Myc , Osm , Pik3ca , Pik3r3 , Stat1 , Stat3
Neoplasm, ResidualCsf2 , Il2
Neoplasms, Second PrimaryCsf3
neovascular glaucomaIl6
nephritisCcnd2 , Ifng , Il4 , Ptk2b
nephroblastomaBcl2l1 , Ccnd2 , Myc , Stat1 , Stat3
nephronophthisisPias1
nephronophthisis-like nephropathy 1Ep300
nephrotic syndromeEpo , Il2 , Il4 , Il5 , Jak2
Nerve DegenerationCntf , Epo , Epor , Ifng , Lep
nervous system diseaseCsf3
Nervous System MalformationsSpred1
neural tube defectCsf2 , Ifng
NeuralgiaIl10
neuroblastomaIfnb1 , Myc , Pik3ca , Ptpn11
neurodegenerative diseaseEpo , Il6
Neurodevelopmental DisordersPtpn11
neuroectodermal tumorMyc
neurofibromaPtpn11
Neurofibromatosis 1Spred1
Neurogenic InflammationIl2
neuromyelitis opticaIl6
neuronal intestinal dysplasiaSpry2
neutropeniaCsf2 , Csf3 , Stat3
NeutrophiliaCsf3
Niemann-Pick disease type C1Jak2 , Stat3
non-Hodgkin lymphomaCcnd1 , Csf2 , Csf3 , Myc , Pik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Cbl , Ccnd1 , Csf3 , Il10 , Il6r , Irf1 , Lep , Myc , Osmr , Pik3ca , Stat3
nonalcoholic fatty liver diseaseCsf2 , Il13 , Il3 , Il4 , Il6 , Jak2 , Lep , Lif , Stat3
Nontuberculous Mycobacterium InfectionsIfngr1 , Ifngr2 , Il12b , Il12rb1 , Stat1 , Tyk2
Noonan Like SyndromeCbl , Ptpn11 , Sos1
Noonan syndromeCbl , Ptpn11 , Sos1
Noonan syndrome 1Ptpn11
Noonan syndrome 3Ptpn11 , Sos1
Noonan syndrome 4Sos1
Noonan syndrome 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl , Ptpn11
obesityAkt1 , Akt2 , Cntf , Ctf1 , Ep300 , Gh1 , Ifng , Il10 , Il15 , Il3 , Il6 , Il6r , Jak2 , Lep , Lepr , Myc , Pik3r1 , Prl , Ptpn1 , Socs1 , Socs3 , Stat3 , Stat4 , Tyk2
Obstetric Labor, PrematureIl6
obstructive sleep apneaIl10 , Il6 , Lep , Lepr
occupational dermatitisIl10 , Il13
ocular hypertensionBcl2l1
Ocular TuberculosisIl10
Ollier diseasePtpn11
onchocerciasisIl13
open-angle glaucomaIl10 , Il2
Optic Nerve InjuriesCsf3 , Ep300
Oral Lichen PlanusIl2
oral squamous cell carcinomaIl13ra2 , Il2 , Il6
oral submucous fibrosisIfng , Il6
Oral UlcerLep , Stat4
orchitisIl6r
osteoarthritisGh1 , Ghr , Il4r , Il5 , Lep
Osteoarthritis, HandIl4 , Il4r
Osteoarthritis, HipGhr , Il11 , Il4r
osteochondrodysplasiaLifr
OsteochondromaPtpn11
osteopetrosisGhr
OsteophytesGh1
osteoporosisGh1 , Ghr , Ifngr1 , Il13ra2 , Il6 , Il6r , Lep , Lepr , Myc
Osteoporotic FracturesGh1
osteosarcomaAkt1 , Il3 , Myc
otitis mediaIfng , Il10 , Il2 , Il6
Otitis Media with EffusionIfng , Il4 , Il4r
ovarian cancerAkt1 , Pik3ca
ovarian hyperstimulation syndromeIl6
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Il10 , Il11ra1 , Il13 , Il6 , Il6st , Myc , Pik3ca , Pik3r1 , Socs1 , Socs2 , Stat3
ovarian serous cystadenocarcinomaPik3ca
OverweightLepr
Oxygen-Induced RetinopathyStat3
PainAkt1 , Csf2 , Csf3 , Il2 , Il6st
Painful NeuropathyEp300
pancreas diseaseIl6 , Lepr
pancreatic adenocarcinomaCcnd1 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Ifng , Il10 , Il13 , Il13ra2 , Il2 , Il24 , Il3 , Il4 , Il4r , Myc , Stat3
pancreatic carcinomaMyc
pancreatic ductal adenocarcinomaCcnd1
pancreatic ductal carcinomaCcnd1 , Il4 , Il4r
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisIl10 , Il13 , Il15 , Lepr
Pancreatitis, Experimental, Acute Bcl2l1 , Il10 , Il4
pancytopeniaCsf3 , Epo
panuveitisIfng , Il10
papillary renal cell carcinomaPik3ca
papillary thyroid carcinomaCcnd1 , Myc
papillomaCcnd1
Paraneoplastic SyndromesEpo
Paranoid DisordersTyk2
paraplegiaAkt1
Parasitic Intestinal DiseasesIl5
Parkinson's diseaseAkt1 , Epo , Il6 , Lep
Parkinsonian DisordersCsf2 , Prl
peanut allergyIl13
pelvic inflammatory diseaseIl4
pemphigusIl2
penile neoplasmCcnd1 , Pik3ca
peptic esophagitisIl13 , Il5
Perennial Allergic RhinitisIfngr1 , Il13 , Il2 , Il4 , Il5
pericardial effusionIl10
perinatal necrotizing enterocolitisIl10 , Il10rb
periodontal diseaseIl15 , Il19 , Il21 , Il24 , Il6 , Il7
periodontitisIfngr1 , Il10 , Il6
peripartum cardiomyopathyStat3
Peripheral Nerve InjuriesGh1 , Il6 , Il6r
peripheral nervous system diseaseCsf3 , Il6
peripheral vascular diseaseIl6
Perisylvian SyndromeCcnd2
peritonitisIfng
phobic disorderPrl
Picornaviridae InfectionsIl13
pituitary gland diseaseLepr
Pituitary NeoplasmsGh1 , Il6st , Prl
placental insufficiencyEpo
plasma cell neoplasmBcl2l1
plasmacytomaIl10 , Pik3ca , Ptpn11
Plasmodium falciparum malariaIl13
pleomorphic xanthoastrocytomaEpo , Il6 , Lep
pleural diseaseIfng , Il4 , Il6
Pleural EffusionIl15
pleurisyCsf3 , Il10 , Il15 , Il6
Pneumococcal MeningitisIl6
Pneumococcal PneumoniaIl15 , Il15ra , Il6 , Lep , Lepr
pneumoconiosisIl4
pneumocystosisCsf2
pneumoniaCsf2 , Ifnar1 , Ifng , Il10 , Il13 , Il13ra2 , Il2rb , Il4 , Il5ra , Il6 , Il6st
Pneumonia, StaphylococcalCsf3 , Ifnar1 , Il10 , Il15
Pneumovirus InfectionsIl21r
PoisoningCsf3 , Epo
polycystic kidney diseaseMyc , Stat6
Polycystic Kidney Disease, Type 1Myc
polycystic ovary syndromeAkt2 , Lep , Lif , Lifr
polycythemiaEpor , Gh1 , Jak2
polycythemia veraBcl2l1 , Epor , Jak1 , Jak2
Polydactyly, Postaxial, Type A1Ccnd2
PolydipsiaLep
PolymicrogyriaAkt3
PolymyositisIfng , Il4 , Il6 , Stat4
polyneuropathyEpo , Il6
Polyomavirus InfectionsIl15
PolyuriaLep
porphyriaEpo
portal hypertensionPik3r1 , Prl
post-traumatic stress disorderIl2
Postmenopausal OsteoporosisIl6 , Il7 , Ptk2b
Postoperative Atrial FibrillationIl6
postpartum depressionIl10
pre-eclampsiaLep , Lepr
pre-malignant neoplasmAkt1 , Ccnd1 , Cish , Il6 , Pim1 , Socs4 , Stat3 , Stat5a
precursor B lymphoblastic lymphoma/leukemiaBcl2l1 , Ccnd1 , Crlf2 , Stat3
precursor lymphoblastic lymphoma/leukemiaBcl2l1 , Ccnd1 , Crebbp , Crlf2 , Csf3 , Gh1 , Ifng , Il10 , Myc
precursor T-lymphoblastic lymphoma/leukemiaCcnd3 , Csf3r , Il7r , Jak3 , Ptpn11 , Ptpn2 , Stat1 , Tyk2
prediabetes syndromeIl15 , Il6
Pregnancy ComplicationsEpo , Jak2
Pregnancy Complications, CardiovascularIl6 , Prl
Pregnancy-associated MalariaIl10
Premature BirthIl4 , Il6
primary biliary cirrhosisIl12a , Il12b , Il4 , Il7r , Jak2 , Lep , Lepr , Stat4 , Tyk2
primary cutaneous amyloidosisOsmr
Primary Graft DysfunctionIl10
primary immunodeficiency diseaseIl2 , Lepr , Stat1
primary polycythemiaEpor
primary progressive multiple sclerosisIl4r
progeriaGh1
prolactinomaMyc , Prl
proliferative diabetic retinopathyIl6r
proliferative vitreoretinopathyIl6
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb
prostate cancerAkt2 , Akt3 , Cntfr , Grb2 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Sos1
prostate carcinomaAkt2
prostate carcinoma in situCcnd1 , Myc , Pim1
prostatic hypertrophyIl13 , Il3 , Il5 , Myc , Prl
Prostatic NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300 , Ghr , Il10 , Il2 , Il24 , Il6 , Il6st , Jak1 , Jak2 , Lep , Lifr , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Ptk2b , Socs1 , Stat1 , Stat3 , Stat5b , Stat6
prostatitisIl10
proteinuriaIfng , Il6 , Lep , Lepr
Proteus syndromeAkt1
Pseudomonas Aeruginosa KeratitisIl10 , Il6
Pseudomonas InfectionsCsf2 , Il13 , Il24
psoriasisCsf2 , Ifnlr1 , Il10 , Il12b , Il13 , Il13ra1 , Il2 , Il20 , Il23a , Il23r , Il3 , Il4 , Il6 , Stat3 , Stat4 , Tyk2
psoriatic arthritisIl12b , Il13 , Stat3 , Stat4
psychotic disorderCntf
PTEN hamartoma tumor syndromePik3ca
Puerperal DisordersPrl
pulmonary alveolar proteinosisCsf2 , Csf2ra , Csf2rb
Pulmonary ContusionIl6
pulmonary edemaIl13
pulmonary embolismEpo
pulmonary emphysemaCsf3 , Il13
pulmonary eosinophiliaIl10 , Il13 , Il5
pulmonary fibrosisCsf2 , Csf3 , Il12b , Il13 , Il15 , Il4 , Il5 , Il6 , Il9 , Lepr , Stat1 , Stat3 , Stat6
pulmonary hypertensionBcl2l1 , Csf3 , Epo , Ifngr1 , Il10 , Il13 , Il13ra1 , Il13ra2 , Il23r , Il4 , Il6 , Myc
pulmonary sarcoidosisIl15
pulmonary tuberculosisIl13 , Il15 , Il4 , Il4r , Il6 , Il6r , Irf1
pulmonary valve stenosisSos1
pulpitisIfng
purpuraIl13
pyelonephritisIl3 , Pim1
Pyogenic GranulomaStat3
quadriplegiaIl6
Radiation InjuriesCsf2
Radiation Injuries, ExperimentalIfng , Il10
Radiation PneumonitisIl13
RASopathiesCbl , Ptpn11 , Sos1 , Spred1
rectal neoplasmPik3ca , Pik3cb
RecurrenceCrlf2
relapsing polychondritisIfng
renal carcinomaPik3ca
renal cell carcinomaAkt1 , Akt3 , Bcl2l1 , Ccnd1 , Ccnd3 , Il13 , Il2 , Il4r , Il6 , Il6r , Lep , Myc , Pik3ca , Pik3r1 , Stat3
renal fibrosisIfng , Myc , Stat6
renal hypertensionIl6
renal tuberculosisIl4r
renovascular hypertensionPrl
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Ccnd1 , Ep300 , Gh1 , Ifng , Il10 , Il12a , Il13 , Il6 , Il6r , Il6st , Irf1 , Jak2 , Lep , Pik3r1 , Ptk2b , Socs1 , Socs3 , Socs4 , Stat1 , Stat2 , Stat3 , Stat5a , Stat5b , Stat6
respiratory allergyIl10 , Il13 , Il13ra1 , Il15 , Il4 , Il6 , Ptpn6 , Tslp
respiratory failureIl15
Respiratory SoundsIl13 , Il4
respiratory syncytial virus infectious diseaseIfng , Il10 , Il13 , Il2ra , Il5 , Il5ra , Il6 , Il9 , Irf1
respiratory system diseaseIfng
Respiratory Tract InfectionsIl13 , Il4 , Il6r , Irf1 , Lepr
Retina Reperfusion InjuryBcl2l1 , Cntf , Il6 , Stat3
retinal artery occlusionIl10 , Il6
retinal degenerationEpo , Il6st
retinal detachmentEpo , Epor , Il6 , Jak2
retinal diseaseIl10
retinal vasculitisIl6
retinal vein occlusionIl6
retinopathy of prematurityEpo , Epor , Il10
RetrognathiaEp300
Retroviridae InfectionsIl10
Rett syndromePtpn1
rhabdoid cancerMyc
rheumatic heart diseaseIl10
rheumatoid arthritisCsf2 , Ifng , Il10 , Il13 , Il2 , Il20 , Il21r , Il23a , Il23r , Il2ra , Il2rb , Il3 , Il4r , Il5 , Il6 , Il6r , Il6st , Jak2 , Ptpn2 , Spred2 , Stat1 , Stat3 , Stat4 , Tyk2
rhinitisIl13 , Il13ra2 , Il15 , Il2 , Il21 , Il22 , Il22ra1 , Il23r , Il4 , Il4r , Il5 , Il9 , Lep
RhinosinusitisIl10 , Il4
Right Ventricular HypertrophyAkt1 , Gh1
Rubinstein-Taybi syndromeCrebbp , Ep300
Salivary Gland NeoplasmsCcnd1
Salmonella Infections, AnimalIfng
salmonellosisIl12b
sarcoidosisIl23r
sarcomaCsf2 , Ifng , Pik3ca
SarcopeniaIl6
Schistosomiasis MansoniIl13
schizophreniaAkt1 , Il10 , Il2ra , Il6 , Il6r , Pik3cb
sciatic neuropathyIl10 , Il6 , Il6r
scoliosisCrebbp , Ptpn11
scrapieJak2 , Stat1 , Stat3
Seasonal Allergic RhinitisIfngr1 , Il10 , Il4
seborrheic keratosisPik3ca
secondary hyperparathyroidismIl6
selective IgG deficiency diseaseIfng
seminomaCcnd2
senile cataractGhr
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossIfng , Il2
SepsisCsf2 , Csf3 , Ep300 , Ghr , Ifng , Il10 , Il12b , Il13 , Il22 , Il6 , Jak2 , Lep , Socs1 , Socs2 , Socs3 , Stat1 , Stat3 , Stat4 , Stat6
Sepsis-Associated EncephalopathyJak2 , Stat3
septic arthritisIfng
Septic PeritonitisCsf3 , Il6 , Pik3r1
Severe Chronic NeutropeniaCsf3r
severe combined immunodeficiencyEpo , Il2 , Il2rg , Il7r , Jak3
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positiveJak3
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-NegativeJak3
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positiveIl7r , Jak3
severe congenital neutropeniaCsf3r
Severe Congenital Neutropenia, Autosomal Recessive, 7Csf3r
sexual disorderPrl
sexual dysfunctionPrl
Sezary's diseaseCrebbp , Il2rg , Stat4
Shock, HemorrhagicBcl2l1 , Epo , Ifng , Il10 , Il4 , Il6 , Myc
short bowel syndromeLep , Lepr
Short Stature, Idiopathic, AutosomalGhr
SHORT SyndromePik3r1
Shwartzman phenomenonIl10 , Il6
sickle cell anemiaIl10 , Il5
silicosisCsf2 , Il2ra
sinusitisIl13 , Il2
Sjogren's syndromeIfng , Il10 , Il12a , Il13 , Il2 , Il23r , Il2ra , Il4 , Il6 , Stat4
skin diseaseIl10 , Il6 , Pias1
skin melanomaAkt1 , Pik3ca , Stat3
Skin NeoplasmsAkt1 , Csf3 , Ptk2b , Stat3
sleep apneaIl6r , Lepr
small cell carcinomaIl6
Smith-Magenis syndromeCsf3 , Gh1 , Grb2 , Socs3 , Socs7 , Stat3 , Stat5a , Stat5b
Soft Tissue NeoplasmsCsf3
Solitary Fibrous TumorsStat6
Somatosensory DisordersCsf3
spina bifidaCrebbp
Spinal Cord CompressionEpo , Epor
Spinal Cord InjuriesAkt1 , Ccnd3 , Csf2 , Csf3 , Epo , Il4 , Il4r , Il6 , Irf1 , Jak2 , Lep , Socs2
Spinal FracturesLepr
SplenomegalyIl10 , Il6st
spondyloarthropathyIl6
Sporadic Papillary Renal Cell CarcinomaMyc , Pik3ca
squamous cell carcinomaAkt1 , Ccnd1 , Crebbp , Ep300 , Il2 , Il6 , Myc , Pik3ca , Ptpn11 , Stat3
Staphylococcal InfectionsCsf3 , Il10 , Il2 , Il4
status asthmaticusIfng , Il5
status epilepticusBcl2l1 , Ccnd1 , Epo , Il6st , Ptk2b , Socs3
Stevens-Johnson syndromeCsf3 , Ep300 , Ifng
stomach cancerIl6st , Irf1 , Pik3ca
Stomach NeoplasmsBcl2l1 , Ccnd1 , Il6 , Il6r , Irf1 , Myc , Pik3ca , Stat3
stomatitisCsf3
StrokeAkt1 , Bcl2l1 , Csf3 , Il10 , Il4r , Il6 , Irf1 , Jak2 , Lif , Pik3ca
Strongylida InfectionsIl3
strongyloidiasisIl5
Stuve-Wiedemann SyndromeLifr
Subarachnoid HemorrhageEpo , Stat3
Subretinal FibrosisIl6 , Il6r
substance-induced psychosisAkt1
Sudden Death, CardiacIl6
suppurative otitis mediaIfng
Surfactant Metabolism Dysfunction, Pulmonary, 4Csf2ra
Surfactant Metabolism Dysfunction, Pulmonary, 5Csf2rb
Systemic Juvenile Rheumatoid ArthritisIl6 , Il6r
systemic lupus erythematosusEp300 , Epor , Ifng , Il10 , Il12b , Il13 , Il2 , Il21 , Il21r , Il23r , Il4 , Il5 , Il6 , Jak1 , Jak2 , Prl , Stat4
systemic sclerodermaIfng , Il13 , Il13ra1 , Il2 , Il23r , Il4 , Il6 , Stat4
Systemic VasculitisCsf3
T-cell large granular lymphocyte leukemiaStat5b
T-cell leukemiaPtpn2 , Stat3
T-Cell LymphomaAkt1 , Ep300 , Il13 , Il13ra2 , Jak3 , Stat3 , Stat5b
T-LymphocytopeniaStat5b
TachycardiaLep
Takayasu's arteritisIl2
temporal arteritisCsf2 , Ifng , Il21r , Il4
Testicular NeoplasmsCcnd2
tetralogy of FallotPtpn11
Thrombocythemia 2Mpl
Thrombocythemia 3Jak2
thrombocytopeniaCsf2 , Csf3 , Epo , Ifnl3 , Il10 , Il3 , Il6 , Mpl
thrombocytopenia-absent radius syndromePias3
thrombocytosisEpor , Jak2 , Mpl
Thrombocytosis, Benign Familial MicrocyticMpl
ThromboembolismJak2
thrombosisEpo , Il10 , Pik3cb
Thumb DeformityCrebbp , Ep300
thyroid cancerMyc
Thyroid Dyshormonogenesis 2ATpo
Thyroid NeoplasmsAkt1 , Akt2 , Ccnd1 , Csf2 , Epo , Epor , Il12b , Il6 , Pik3ca
Thyroiditis, ChronicIfng
thyrotoxicosisIl10
TinnitusIl4r
Tobacco Use DisorderIl6
Tongue NeoplasmsStat3
tongue squamous cell carcinomaIfng , Il10 , Il2 , Jak3
toxic encephalopathyBcl2l1 , Il10
toxic shock syndromeIl10 , Il19 , Il20ra , Il20rb , Il6
Toxoplasma ChorioretinitisIl10 , Il6
Toxoplasmosis, OcularIl10
trachomaIl10
transient cerebral ischemiaCbl , Csf3 , Ep300 , Epo , Il10 , Jak2 , Stat3
transitional cell carcinomaAkt1 , Bcl2l1 , Ccnd1 , Ccnd2 , Crebbp , Csf3 , Ep300 , Ifnb1 , Pik3ca
Transplant RejectionCsf3 , Ifng , Il10 , Il13 , Il15 , Il2 , Il5 , Il7 , Myc , Stat4 , Tpo
Transverse MyelitisIl6
Trauma, Nervous SystemStat1
TrichiasisJak3
trichinosisIl10
trichuriasisIfng
trypanosomiasisIl4
tuberculosisIfngr1 , Il15 , Il22
tuberous sclerosisIfng
tuberous sclerosis 2Ifng
Tubulointerstitial FibrosisEpo
Turner syndromeGh1
Tympanic Membrane PerforationIl6
type 1 diabetes mellitusCbl , Cblb , Gh1 , Ghr , Ifng , Ifngr2 , Il10 , Il15 , Il19 , Il2 , Il20 , Il21r , Il2ra , Il4 , Il6 , Stat3 , Stat4 , Tyk2
type 1 diabetes mellitus 10Il2ra
type 2 diabetes mellitusAkt1 , Akt2 , Bcl2l1 , Ccnd2 , Ctf1 , Ep300 , Epo , Gh1 , Ghr , Ifng , Il10 , Il6 , Lep , Lepr , Pik3cb , Pik3r1 , Ptpn1 , Socs3 , Stat3
Tyrosine Kinase 2 DeficiencyTyk2
ulcerative colitisIl10 , Il12b , Il23r , Il7r , Jak2 , Ptpn2 , Stat3
uremiaEpo
ureteral obstructionAkt1 , Ifng , Irf1
urinary bladder cancerAkt1 , Bcl2l1 , Ccnd1 , Ccnd3 , Crebbp , Csf3 , Ep300 , Ifnb1 , Ifng , Il2 , Myc , Socs1
urinary schistosomiasisIl5 , Stat6
Urologic NeoplasmsCcnd1
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Ccnd3 , Crebbp , Ep300 , Il10 , Jak2 , Myc , Pias3 , Pik3ca , Sos1 , Stat3
Uterine NeoplasmsBcl2l1 , Csf3 , Pik3ca , Pik3r1 , Sos1
uveitisIfng , Il10 , Il13 , Il2 , Il21r , Il23r , Il6 , Il6r
Vaginal NeoplasmsIl2
Varicose UlcerLepr
vascular dementiaEpo
vascular diseaseEpo , Il15
Vascular MalformationsPik3ca
vasculitisCbl , Il10
Venous ThrombosisCsf2 , Epo , Il10 , Jak2
Ventilator-Induced Lung InjuryAkt1 , Il10 , Il22
Ventricular Dysfunction, LeftCsf3 , Il6
Ventricular FibrillationEpo
ventricular septal defectEpo
Ventricular TachycardiaEpo
vesicoureteral refluxIfng
Viral BronchiolitisCsf2 , Il4r , Il6 , Il9
viral infectious diseaseIfnar1 , Il15
Viral MyocarditisIfng
viral pneumoniaIfnar1 , Il10 , Il15
visceral leishmaniasisCsf2 , Ifng , Il10 , Il10ra , Il6 , Stat4
visual epilepsyCcnd1 , Epo , Ghr , Ifnb1 , Ifng , Il6 , Il6r , Il6st , Lep , Pik3ca
vitiligoIfng , Il13 , Il2 , Il4 , Pik3r1
Vogt-Koyanagi-Harada diseaseIfng , Stat4
VomitingIfng
von Hippel-Lindau diseaseCcnd1
Waldenstroem's macroglobulinemiaIl10 , Il6
Weight GainGh1 , Lep , Pik3ca
Weight LossEpo , Il10 , Il4 , Lep , Lif
Wilson diseaseIl10 , Il6
withdrawal disorderPrl
Wounds and InjuriesIl10 , Il6
Wounds, PenetratingEpo , Il10
X-linked severe combined immunodeficiencyIl2rg
XerostomiaIl4
Pathway Annotations Associated with Genes in the Jak-Stat signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pim1 , Sos1 , Sos2 , Stat3 , Stat5a , Stat5b
adenosine signaling pathwayAkt1 , Pik3ca
aldosterone signaling pathwayCrebbp , Jak2 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
allograft rejection pathwayIfng , Il10 , Il12a , Il12b , Il2 , Il4 , Il5
altered energy homeostasis pathwayLep , Lepr
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered Jak-Stat signaling pathwayJak2 , Jak3
altered leptin system pathwayLep , Lepr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
amyotrophic lateral sclerosis pathwayBcl2l1
androgen signaling pathwayCrebbp , Ep300 , Pias2
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2 , Tyk2
angiotensin II signaling pathway via AT2 receptorPtpn6
antigen processing and presentation pathwayIfng
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Csf2rb , Il3 , Il3ra , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
asthma pathwayIl10 , Il13 , Il3 , Il4 , Il5 , Il9
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1 , Pias4
autoimmune thyroiditis pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Il10 , Il2 , Il4 , Il5 , LOC100911527 , Tpo
autophagy pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifng , LOC100911527
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn6 , Sos1 , Sos2
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayPtk2b
cell cycle pathway, mitoticCcnd1 , Ccnd2 , Ccnd3 , Crebbp , Ep300 , Myc
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il10 , Il12a , Il12b , Il2 , Il6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Jak2 , Jak3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptk2b , Sos1 , Sos2 , Stat1 , Stat2 , Stat3 , Stat5b
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Cbl , Cblb , Cblc , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2 , Stat5a , Stat5b
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayClcf1 , Cntf , Cntfr , Crlf2 , Csf2 , Csf2ra , Csf2rb , Csf3 , Csf3r , Ctf1 , Epo , Epor , Ghr , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Ifnk , Ifnlr1 , Il10 , Il10ra , Il10rb , Il11 , Il11ra1 , Il12a , Il12b , Il12rb1 , Il12rb2 , Il13 , Il13ra1 , Il15 , Il2 , Il20ra , Il20rb , Il21 , Il21r , Il22 , Il22ra1 , Il22ra2 , Il23a , Il23r , Il2ra , Il2rb , Il2rg , Il3 , Il3ra , Il4 , Il4r , Il5 , Il5ra , Il6 , Il6r , Il6st , Il7 , Il7r , Il9 , Il9r , Lep , Lepr , Lif , Lifr , LOC100911527 , Mpl , Osm , Osmr , Prl , Prlr , Tpo , Tslp
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Pik3r5
endocytosis pathwayCbl , Cblb , Cblc , Il2ra , Il2rb , Il2rg , Stam , Stam2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
endothelin signaling pathwayAkt1 , Jak2 , Ptk2b
energy homeostasis pathwayLep , Lepr
Entamoebiasis pathwayCsf2 , Ifng , Il10 , Il12a , Il12b , Il6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisCbl , Grb2 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Cbl , Cblb , Cblc , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn1 , Ptpn11 , Ptpn6 , Sos1 , Sos2 , Stat1 , Stat3 , Stat5a , Stat5b
erythropoietin signaling pathwayBcl2l1 , Cbl , Epo , Epor , Grb2 , Jak2 , Pik3r1 , Ptpn11 , Ptpn6 , Socs3 , Sos1 , Stat1 , Stat5a , Stat5b
estrogen signaling pathwayCrebbp , Ep300
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Csf2 , Grb2 , Il13 , Il3 , Il4 , Il5 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
fibroblast growth factor signaling pathwayAkt1 , Cbl , Grb2 , Pik3ca , Pik3r1 , Ptk2b , Ptpn11 , Sos1 , Spry2 , Stat1 , Stat5b
forkhead class A signaling pathwayAkt1 , Crebbp , Ep300
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1 , Ccnd2 , Ccnd3
glioma pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
gonadotropin-releasing hormone signaling pathwayGrb2 , Ptk2b , Sos1 , Sos2
graft-versus-host disease pathwayIfng , Il2 , Il6
granulocyte-macrophage colony-stimulating factor signaling pathwayCish , Csf2 , Csf2rb , Grb2 , Jak2 , Osm , Pik3ca , Pik3r1 , Pim1 , Ptpn11 , Sos1 , Stat1 , Stat3 , Stat5a , Stat5b
growth hormone signaling pathwayGhr , Jak2
Hedgehog signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Grb2 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Irf1 , Irf9 , Jak1 , LOC100911527 , Pias1 , Pias2 , Pias3 , Pias4 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Sos1 , Sos2 , Stat1 , Stat2 , Stat3
histone modification pathwayCrebbp , Ep300
Huntington's disease pathwayCrebbp , Ep300
hypertrophic cardiomyopathy pathwayIl6
hypoxia inducible factor pathwayAkt1 , Crebbp , Ep300 , Epo , Lep
influenza A pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ifng , Ifngr1 , Ifngr2 , Il12a , Il12b , Il6 , Irf9 , Jak1 , Jak2 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Stat1 , Stat2
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Cbl
insulin signaling pathwayAkt1 , Akt2 , Akt3 ,