TYPE 2 DIABETES MELLITUS PATHWAY (PW:0000208)

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Description

Type 2 diabetes mellitus (T2D) is reaching epidemic proportions worldwide, yet the genetic underpinnings of the disease continue to be remarkably elusive. The importance and impact of environmental factors such as diet and lifestyle on the susceptibility to the disease only add additional challenges to the identification of genetic causes. While it is known that several pathways important for the maintenance of glucose homeostasis are altered in T2D, less is known about the molecular mechanisms

Pathway Diagram:

Elsevier Inc. anti-diabetic drug pathway Abcc8 Kcnj11 type 2 diabetes mellitus diabetic complications other T2D candidate genes potential T2D miRNAs altered insulin secretion pathway Insr Akt2 altered insulin signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered insulin responsive facilitative sugar transporter mediated glucose transport pathway metformin drug pathway other T2D candidate genes ---> insulin gene expression potential T2D miRNAs ---> insulin secretion potential T2D miRNAs ---> insulin gene expression beta-cell function insulin gene expression insulin secretion other T2D candidate genes ---> insulin secretion Islet development potential T2D miRNAs ---> Islet development other T2D candidate genes ---> beta-cell function insulin action potential T2D miRNAs ---> insulin action anti-diabetic drug pathway ---| altered insulin secretion pathway high blood glucose potential T2D miRNAs ---> diabetic complications potential T2D miRNAs ---> type 2 diabetes mellitus metformin drug pathway ---| diabetic complications metformin drug pathway ---| type 2 diabetes mellitus metformin drug pathway ---| high blood glucose Ins
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Genes in Pathway:

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type 2 diabetes mellitus pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2313628
RGD:6907045
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313408
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6907045
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6907045
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6907045
G Hk3 hexokinase 3 JBrowse link 17 10,134,726 10,152,976 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
RGD:6907045
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694
RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6907045
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6907045
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
G Kcnj11 potassium voltage-gated channel subfamily J member 11 JBrowse link 1 102,103,093 102,107,134 RGD:2313610
RGD:6907045
RGD:2313628
G Mafa MAF bZIP transcription factor A JBrowse link 7 116,779,368 116,781,815 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6907045
G Pdx1 pancreatic and duodenal homeobox 1 JBrowse link 12 9,496,044 9,501,211 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pklr pyruvate kinase L/R JBrowse link 2 188,449,158 188,458,034 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6907045
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:6907045
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6907045
G Slc2a2 solute carrier family 2 member 2 JBrowse link 2 114,413,427 114,445,418 RGD:6907045
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6907045
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6907045
G Socs2 suppressor of cytokine signaling 2 JBrowse link 7 36,495,496 36,500,878 RGD:6907045
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6907045
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupOther T2D candidate genesCandidate genes have been identified in linkage analyses and GWAS studies as potential susceptibility loci for T2D;
Gene GroupPotential T2D miRNAsSeveral microRNAs (miRNAs) with potential roles in beta-cell and insulin function as well as in diabetic complications [see for instance the references PMID: 18655850 or 19471090] have been identified in humans and animal models.

Pathway Gene Annotations

Disease Annotations Associated with Genes in the type 2 diabetes mellitus pathway
Disease TermsGene Symbols
3MC syndrome 1Adipoq
abdominal aortic aneurysmMapk8
Aberrant Crypt FociMapk1 , Mapk3
acneTnf
acquired immunodeficiency syndromeTnf
Acute Coronary SyndromeTnf
acute kidney failureIns2 , Mtor , Tnf
Acute Liver FailureIns1 , Ins2 , Mapk8 , Tnf
Acute Lung InjuryAdipoq , Tnf
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaMtor , Pik3ca , Tnf
adenoid cystic carcinomaPik3ca
adenomaCacna1d , Ins2
Adenosine Triphosphate, Elevated, of ErythrocytesPklr
Adiponectin, Serum Level of, Quantitative Trait Locus 2Adipoq
Adiponectin, Serum Level of, Quantitative Trait Locus 3Adipoq
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adult respiratory distress syndromeTnf
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexInsr , Irs1
AIDS-Associated NephropathyMtor
AlbuminuriaIns2 , Tnf
Alcoholic Fatty LiverAdipoq
alcoholic hepatitisTnf
alcoholic liver cirrhosisTnf
allergic bronchopulmonary aspergillosisTnf
allergic contact dermatitisSocs1 , Socs2 , Tnf
allergic hypersensitivity diseaseTnf
Alveolar Bone LossTnf
Alzheimer's diseaseAdipoq , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Slc2a4 , Tnf
amyloidosisAdipoq , Tnf
amyotrophic lateral sclerosisCacna1a , Tnf
amyotrophic lateral sclerosis type 1Tnf
anemiaHk1 , Tnf
Anemia, RefractoryTnf
Angina, StableTnf
Animal Disease ModelsCacna1d , Hk1 , Hk2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
ankylosing spondylitisAdipoq
AnorexiaTnf
anterior uveitisTnf
anthracosisTnf
anti-basement membrane glomerulonephritisMapk8 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTnf
anxiety disorderTnf
aplastic anemiaTnf
Arsenic PoisoningTnf
arteriosclerosisMapk9
asbestosisTnf
aspiration pneumoniaTnf
asthmaAdipoq , Tnf
Asthma, OccupationalTnf
astrocytomaAkt2
AtaxiaCacna1a
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAdipoq , Socs3 , Tnf
atopic dermatitisMapk8 , Tnf
atrial fibrillationTnf
atrial heart septal defectAbcc8
AtrophyMapk3
autism spectrum disorderMapk3
autistic disorderCacna1c , Mapk1 , Tnf
autoimmune hepatitisAdipoq
autoimmune lymphoproliferative syndrome type 3Prkcd
autoimmune thyroiditisTnf
autosomal dominant polycystic kidney diseaseMtor
autosomal recessive limb-girdle muscular dystrophy type 2NInsr
autosomal recessive polycystic kidney diseaseMtor , Pik3ca
bacterial pneumoniaTnf
Bannayan-Riley-Ruvalcaba syndromePik3ca
basal cell carcinomaPik3ca
Behcet's diseaseAdipoq , Tnf
berylliosisTnf
beta thalassemiaTnf
biliary atresiaAdipoq
bilirubin metabolic disorderTnf
bipolar disorderAdipoq , Cacna1c , Cacna1d , Ins2
bladder diseaseIns2
bladder urothelial carcinomaPik3ca
BradycardiaCacna1d
brain edemaAbcc8 , Tnf
brain infarctionAdipoq
Brain InjuriesAbcc8 , Tnf
brain ischemiaMapk1 , Mapk3 , Mapk8 , Prkcd , Tnf
Brain NeoplasmsPik3ca , Pik3r1
breast adenocarcinomaPik3ca
breast cancerMtor , Pik3ca
Breast Cancer, FamilialPik3r3
breast ductal carcinomaCacna1c
Breast NeoplasmsAdipoq , Akt2 , Ikbkb , Insr , Mapk1 , Mtor , Pik3ca , Pik3r1 , Slc2a2 , Socs1 , Socs2 , Tnf
Bronchial HyperreactivityTnf
bronchiectasisTnf
Bronchopulmonary DysplasiaTnf
Brugada syndromeCacna1c
Brugada syndrome 3Cacna1c
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsMtor , Pklr , Prkcd , Socs3 , Tnf
CachexiaTnf
carcinomaPik3r1
cardiac arrestAbcc8 , Ins2 , Tnf
Cardiac ArrhythmiasCacna1c
Cardiac Complexes, PrematureCacna1c
CardiomegalyMapk1 , Mapk8 , Mtor , Prkcd , Prkce , Prkcz , Slc2a4 , Tnf
cardiomyopathyAdipoq , Insr , Mapk1 , Mapk3 , Prkce , Tnf
cardiovascular system diseaseAdipoq
Cardiovirus InfectionsTnf
Cell Transformation, NeoplasticIrs1 , Mapk8
cerebellar ataxiaCacna1a
Cerebral HemorrhageMtor
cerebral infarctionPdx1 , Tnf
Charcot-Marie-Tooth disease type 4GHk1
Chemical and Drug Induced Liver InjuryAdipoq , Tnf
childhood absence epilepsyCacna1a
childhood electroclinical syndromeCacna1a
chlamydiaTnf
cholestasisTnf
cholesteatoma of middle earTnf
chondrosarcomaMtor
chorioamnionitisTnf
choriocarcinomaInsr
Choroidal NeovascularizationAdipoq , Ikbkb
Chronic Allograft DysfunctionMtor , Tnf
Chronic Intermittent HypoxiaHk1 , Hk2
chronic kidney diseaseInsr
Chronic Lymphocytic Leukemia, B-CellTnf
chronic obstructive pulmonary diseaseAdipoq , Mapk8 , Tnf
cicatricial pemphigoidTnf
Cocaine-Related DisordersMapk1 , Mapk3
cognitive disorderIns2
Cognitive DysfunctionAdipoq
colitisAdipoq , Ikbkb , Tnf
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3
colon cancerPik3ca
colon carcinomaPik3ca
Colonic NeoplasmsAkt2 , Ikbkb , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Tnf
colorectal adenocarcinomaMapk1 , Mapk3 , Mapk8
colorectal adenomaMapk8
colorectal cancerPik3ca
Colorectal NeoplasmsAbcc8 , Akt2 , Hk1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Prkce , Tnf
complex cortical dysplasia with other brain malformationsMtor , Pik3ca
congenital diaphragmatic herniaTnf
Congenital HyperinsulinismAbcc8 , Gck , Kcnj11
Congenital Limb DeformitiesCacna1c
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congenital myasthenic syndrome 10Cacna1c
congenital nonspherocytic hemolytic anemiaHk1 , Pklr
congestive heart failureAdipoq , Ins2 , Mtor , Slc2a4 , Tnf
Cor pulmonaleTnf
corneal ulcerTnf
coronary aneurysmAdipoq
coronary artery diseaseAdipoq , Gck , Irs1 , Tnf
Coronary DiseaseAdipoq , Irs1
coronary restenosisAdipoq , Mapk1 , Tnf
coronary stenosisPrkce
coronin-1A deficiencyMapk3
CoughTnf
Cowden diseasePik3ca
Cowden Syndrome 5Pik3ca
Cowden-Like SyndromePik3ca
Coxsackievirus InfectionsTnf
crescentic glomerulonephritisMtor
Crohn's diseaseAdipoq , Tnf
cryoglobulinemiaTnf
Currarino TriadPik3ca
cutaneous leishmaniasisTnf
Cutaneous Malignant Melanoma, Susceptibility To, 1Cacna1c , Pik3ca
cystic fibrosisTnf
cystic kidney diseaseIns2
cystitisTnf
Cytomegalovirus InfectionsTnf
cytomegalovirus retinitisTnf
DeafnessCacna1d
dementiaAdipoq
demyelinating diseaseTnf
dermatitisIkbkb , Tnf
dermatitis herpetiformisTnf
dermatomyositisTnf
Developmental DisabilitiesCacna1a , Pik3r2
diabetes mellitusAbcc8 , Adipoq , Gck , Ins1 , Ins2 , Insr , Irs1 , Kcnj11 , Mafa , Pdx1 , Slc2a2
Diabetes Mellitus, Insulin-Resistant, with Acanthosis NigricansInsr
Diabetes Mellitus, New-Onset after TransplantationMtor
diabetic angiopathyTnf
Diabetic CardiomyopathiesAdipoq , Ins2 , Tnf
Diabetic FootAdipoq
diabetic ketoacidosisIns2 , Insr
Diabetic NephropathiesAdipoq , Cacna1b , Ins2 , Irs2 , Mapk1 , Mtor , Prkce , Tnf
diabetic neuropathyInsr , Tnf
diabetic retinopathyAdipoq , Ins2 , Tnf
diffuse large B-cell lymphomaPik3ca , Pik3cb , Pik3cd
diffuse sclerodermaAdipoq
dilated cardiomyopathyCacna1c , Tnf
dilated cardiomyopathy 1HTnf
disease by infectious agentTnf
disease of cellular proliferationPik3ca , Pik3r1
disease of metabolismIns2
Disease ProgressionPik3ca
disseminated intravascular coagulationTnf
Donohue syndromeInsr
drug allergyTnf
Drug-Induced DyskinesiaCacna1d , Mtor
dry eye syndromeAdipoq , Tnf
ductal carcinoma in situSocs1 , Socs2 , Socs3
DysarthriaCacna1a
dystoniaCacna1b , Ins2
dystonia 23Cacna1b
Eales DiseaseTnf
Early Infantile Epileptic Encephalopathy, 42Cacna1a
EdemaIns2 , Tnf
EmphysemaTnf
encephalitisTnf
encephalomyelitisTnf
end stage renal failureAdipoq , Irs1 , Mtor , Tnf
endometrial cancerPik3cb , Pik3r1
endometrial carcinomaPik3ca , Pik3r1
Endometrial NeoplasmsAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Socs2 , Socs3
Endometrioid CarcinomasPik3r2
endometriosisTnf
endophthalmitisTnf
EndotoxemiaAbcc8 , Adipoq , Irs1 , Socs1 , Socs3 , Tnf
epidermal nevusPik3ca
epilepsyCacna1c , Tnf
episodic ataxia type 2Cacna1a
Erythema NodosumTnf
esophageal carcinomaPik3ca
Esophageal NeoplasmsPik3ca
esophagitisTnf
esophagus adenocarcinomaPik3ca
exfoliation syndromeCacna1a
Experimental ArthritisAdipoq , Ikbkb , Mtor , Pik3cd , Socs3 , Tnf
Experimental Autoimmune EncephalomyelitisCacna1b , Tnf
Experimental Autoimmune MyocarditisAdipoq
Experimental Autoimmune NeuritisTnf
Experimental ColitisTnf
Experimental Diabetes MellitusAdipoq , Gck , Hk1 , Ikbkb , Insr , Irs1 , Irs2 , Kcnj11 , Mafa , Mapk1 , Mapk3 , Mtor , Pdx1 , Pik3r1 , Pklr , Prkcd , Prkce , Slc2a2 , Slc2a4 , Socs3 , Tnf
Experimental Liver CirrhosisAdipoq , Gck , Ins2 , Mtor , Pklr , Prkcd , Socs1 , Socs2 , Tnf
Experimental NeoplasmsTnf
extrahepatic cholestasisMapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
extrinsic allergic alveolitisTnf
eye diseaseTnf
Facial AsymmetryPik3ca
familial hemiplegic migraineCacna1a
Familial Hemiplegic Migraine, Type 1Cacna1a
familial hyperlipidemiaAdipoq , Irs1
familial Mediterranean feverAdipoq
familial partial lipodystrophyAkt2
Fanconi anemiaTnf
Fanconi syndromeSlc2a2
farmer's lungTnf
fatty liver diseaseAdipoq , Gck , Ins2 , Mapk8 , Prkcd , Slc2a2 , Socs1 , Socs3 , Tnf
Female InfertilityMapk1 , Mapk3
Fetal Growth RetardationAdipoq , Irs1 , Irs2 , Pdx1 , Slc2a2
FeverTnf
Fibromatosis, AggressiveTnf
FibrosisSocs3 , Tnf
Focal Cortical Dysplasia of TaylorMtor
focal segmental glomerulosclerosisTnf
Fungal Lung DiseasesTnf
gastric adenocarcinomaMtor , Pik3ca
gastric ulcerTnf
gastrinomaSlc2a2
gastritisTnf
Gastrointestinal NeoplasmsPik3ca
Gaucher's diseasePklr , Tnf
generalized dystoniaCacna1a
Generalized EpilepsyCacna1a , Mapk10
genetic diseaseAkt2 , Cacna1a , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Gck , Mapk1 , Mtor , Pik3ca , Pik3r1 , Pik3r2
gestational diabetesAdipoq , Gck , Ins2 , Insr
glaucomaTnf
glioblastoma multiformeMtor , Pik3ca , Pik3r1
GliosisMapk1 , Mapk3
glomerulonephritisMapk1 , Tnf
GlucagonomaSlc2a2
glucose intoleranceIns2 , Insr
glycogen storage diseaseSlc2a2
Graft vs Host DiseaseAdipoq
Graves OphthalmopathyTnf
Graves' diseaseAdipoq , Tnf
Growth DisordersPik3ca
Growth Restriction, Severe, with Distinctive FaciesIns1
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
head and neck squamous cell carcinomaMapk1 , Pik3ca
Hearing LossTnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedTnf
Hearing Loss, SuddenTnf
Heart BlockCacna1d
Heat StrokeTnf
Helicobacter InfectionsSocs3
HemimegalencephalyMtor , Pik3ca
hemochromatosisTnf
Hemolytic Anemia, Nonspherocytic, due to Hexokinase DeficiencyHk1
hemolytic-uremic syndromeTnf
hepatic encephalopathyTnf
HepatitisIns2
hepatocellular carcinomaAkt2 , Irs1 , Irs2 , Mtor , Pik3ca , Slc2a2 , Socs3 , Tnf
hepatorenal syndromeTnf
hereditary hemorrhagic telangiectasiaTnf
Hereditary Neoplastic SyndromesPik3ca
Hernias, Diaphragmatic, CongenitalInsr , Tnf
heroin dependenceAdipoq
herpes simplex virus keratitisTnf
herpes zosterTnf
hidradenitis suppurativaTnf
HirsutismCacna1g
HIV Wasting SyndromeTnf
HIV-Associated Lipodystrophy SyndromeAdipoq
human immunodeficiency virus infectious diseaseSocs1 , Socs3 , Tnf
Human InfluenzaTnf
Huntington's diseaseAdipoq
HyperalgesiaCacna1b , Insr , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Prkce , Prkcz , Tnf
Hyperbilirubinemia, NeonatalIkbkb
hypercalcemiaTnf
HyperemiaAdipoq
hyperglycemiaCacna1e , Gck , Ins2 , Insr , Irs2 , Pdx1 , Pklr , Prkcz
hyperhomocysteinemiaTnf
hyperinsulinemic hypoglycemiaAbcc8 , Gck , Insr , Kcnj11
Hyperinsulinemic Hypoglycemia, Familial, 3Gck
Hyperinsulinemic Hypoglycemia, Familial, 5Insr
hyperinsulinismAbcc8 , Adipoq , Gck , Ins2 , Insr , Irs1 , Kcnj11 , Pklr , Prkcd
HyperkalemiaIns2
HyperoxiaTnf
HyperplasiaAbcc8 , Ikbkb , Pik3ca
HyperproinsulinemiaIns1 , Ins2
hypertensionAbcc8 , Adipoq , Akt2 , Cacna1c , Gck , Ikbkb , Ins2 , Kcnj11 , Mapk8 , Mtor , Pik3r1 , Prkcd , Prkce , Tnf
hyperthyroidismAdipoq
hypertrichosisKcnj11
HypertriglyceridemiaAdipoq , Ins2 , Mtor , Socs1 , Socs3
hypertrophic cardiomyopathyIns2
hypertrophic cardiomyopathy 1Cacna1c
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularAdipoq , Cacna1g , Kcnj11 , Mtor , Prkcd , Prkcz
Hypertrophy, Right VentricularMtor , Prkcd
hyperuricemiaIns2
HypoadiponectinemiaAdipoq
hypochromic microcytic anemiaTnf
hypoglycemiaAbcc8 , Akt2 , Cacna1c , Gck , Ins2 , Kcnj11 , Pik3r1 , Tnf
Hypoglycemia, Leucine-InducedAbcc8
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypokalemiaIns2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypotensionIns2 , Tnf
HypothermiaTnf
idiopathic interstitial pneumoniaMtor
idiopathic pulmonary fibrosisTnf
IgA glomerulonephritisTnf
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
impotenceTnf
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
InflammationAdipoq , Mtor , Tnf
inflammatory bowel diseaseAdipoq , Ikbkb , Tnf
Insulin ResistanceAdipoq , Akt2 , Gck , Ikbkb , Ins2 , Insr , Irs1 , Irs2 , Kcnj11 , Pdx1 , Pik3r1 , Pklr , Prkcd , Prkcz , Slc2a4 , Socs1 , Socs3 , Tnf
insulinomaIns2 , Slc2a2
intellectual disabilityCacna1g
intermediate uveitisTnf
interstitial cystitisMtor , Tnf
Intervertebral Disc DisplacementTnf
Intestinal NeoplasmsMapk8 , Prkcd
intracranial aneurysmTnf
Intracranial HemorrhagesTnf
Intrahepatic Cholestasis of PregnancyTnf
invasive ductal carcinomaSocs1 , Socs2 , Socs3
iron deficiency anemiaTnf
ischemiaAkt2 , Mapk9
Islet Cell AdenomatosisMafa
JaundiceAdipoq
juvenile rheumatoid arthritisMapk1
Kawasaki diseaseAdipoq , Tnf
keratoconjunctivitis siccaTnf
kidney angiomyolipomaMtor
kidney diseaseMapk1 , Tnf
kidney failureIns2
Kidney NeoplasmsMapk1 , Mapk3
Kidney Reperfusion InjuryAdipoq , Ikbkb , Kcnj11 , Tnf
Kuhnt-Junius degenerationMapk8
labyrinthitisTnf
Lambert-Eaton myasthenic syndromeCacna1a , Cacna1b
leishmaniasisTnf
Lennox-Gastaut syndromeMapk10
leprosyTnf
leukemiaPrkcz
Lewy body dementiaIns2 , Insr
lipoatrophic diabetes mellitusInsr
lipodystrophyInsr
listeriosisTnf
liver cancerPik3ca
liver cirrhosisAdipoq
liver diseaseHk3 , Socs1 , Socs3 , Tnf
Liver InjuryGck
liver neoplasmPrkce , Tnf
Liver Neoplasms, ExperimentalMapk1 , Mapk3 , Socs1 , Tnf
Liver Reperfusion InjuryAdipoq , Mapk8 , Tnf
localized sclerodermaTnf
long QT syndromeCacna1c , Hk3
low tension glaucomaTnf
lung adenocarcinomaHk1 , Hk2 , Pik3ca , Pik3r1
lung cancerPik3ca
lung diseaseInsr , Tnf
Lung InjuryMtor , Tnf
Lung NeoplasmsMapk1 , Mapk3 , Mtor , Pik3ca , Tnf
Lung Reperfusion InjuryTnf
lung small cell carcinomaPik3ca
lung squamous cell carcinomaPik3ca
lupus nephritisMtor , Tnf
Lymphatic MetastasisPik3ca , Pik3cb , Socs2 , Socs3
lymphopeniaTnf
malariaPklr , Tnf
malignant gliomaAkt2 , Pik3ca , Tnf
Mammary Neoplasms, AnimalPik3r1
Mammary Neoplasms, ExperimentalAdipoq , Akt2 , Mtor , Pik3r1 , Socs1 , Socs3 , Tnf
Manganese PoisoningTnf
mantle cell lymphomaMtor , Pik3cd
Marshall-Smith syndromeCacna1a
Masked HypertensionAdipoq
maturity-onset diabetes of the youngAbcc8 , Gck , Ins1 , Ins2 , Kcnj11 , Mafa , Pdx1
maturity-onset diabetes of the young type 10Ins1 , Ins2
maturity-onset diabetes of the young type 13Kcnj11
maturity-onset diabetes of the young type 2Gck , Kcnj11
maturity-onset diabetes of the young type 4Pdx1
medulloblastomaIrs2 , Pik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
melanomaCacna1c , Mtor , Pik3ca , Pik3r1 , Tnf
Melanoma, ExperimentalIkbkb
Memory DisordersCacna1d , Ins2
Meningeal TuberculosisTnf
MesotheliomaMtor
Metabolic SyndromeAdipoq , Ins2 , Irs1 , Tnf
MetaplasiaPdx1
mevalonic aciduriaTnf
Micronuclei, Chromosome-DefectiveIns2
middle cerebral artery infarctionAbcc8 , Ikbkb , Mtor , Tnf
migraineCacna1a , Tnf
migraine with auraCacna1a
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
migraine without auraTnf
Migraine, Sporadic HemiplegicCacna1a
mitochondrial myopathyTnf
mixed connective tissue diseaseTnf
Mouth NeoplasmsPik3ca
MPTP PoisoningIns2
mucocutaneous leishmaniasisTnf
Multiple AbnormalitiesCacna1c , Cacna1g , Mapk1 , Pik3r2
Multiple Hamartoma SyndromePik3ca
multiple myelomaHk1 , Pik3ca , Tnf
Multiple Organ FailureMapk1 , Tnf
multiple sclerosisAdipoq , Cacna1b , Tnf
muscular atrophyIkbkb , Mtor , Tnf
muscular diseaseIns2 , Prkcd
muscular dystrophyTnf
Muscular Dystrophy, AnimalMtor
Mycobacterium avium complex diseaseAdipoq , Tnf
Mycoplasma pneumoniae pneumoniaTnf
myelodysplastic syndromeTnf
myocardial infarctionAdipoq , Mapk1 , Mtor , Prkce , Socs1 , Tnf
Myocardial IschemiaAdipoq , Hk1 , Hk2 , Kcnj11 , Prkcd , Prkce , Socs3 , Tnf
Myocardial Reperfusion InjuryAbcc8 , Adipoq , Akt2 , Kcnj11 , Mapk1 , Mapk8 , Prkcd , Slc2a4 , Tnf
myocardial stunningTnf
myocarditisAdipoq , Tnf
myositisTnf
narcolepsySocs2
Nasal PolypsTnf
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaAkt2 , Pik3ca
NauseaTnf
NecrosisAbcc8 , Tnf
Nematode InfectionsPik3r1
neonatal diabetes mellitusAbcc8 , Gck , Ins1 , Ins2 , Kcnj11 , Pdx1
Neoplasm InvasivenessMapk1 , Mapk3 , Tnf
Neoplasm MetastasisAkt2 , Mapk1 , Mapk3 , Mapk9 , Mtor , Pik3ca , Pik3r3 , Tnf
nephritisMtor
Nerve DegenerationMapk1 , Mapk3 , Tnf
nervous system diseaseTnf
NesidioblastosisAbcc8 , Kcnj11
neural tube defectIns2 , Slc2a2
NeuralgiaTnf
neuroblastomaPik3ca
Neurogenic InflammationTnf
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
Neuropathy, PainfulTnf
neutropeniaTnf
non-Hodgkin lymphomaPik3ca
non-small cell lung carcinomaAkt2 , Pik3ca , Tnf
nonalcoholic fatty liver diseaseAdipoq , Irs1 , Irs2 , Mapk8 , Tnf
obesityAdipoq , Akt2 , Gck , Hk1 , Hk2 , Ikbkb , Ins2 , Irs1 , Irs2 , Mtor , Pdx1 , Pik3r1 , Pklr , Prkcd , Socs1 , Socs3 , Tnf
obstructive sleep apneaTnf
open-angle glaucomaTnf
oral submucous fibrosisTnf
osteoarthritisIns2 , Mtor
OsteolysisTnf
osteoporosisIrs1 , Irs2
Osteoporosis, PostmenopausalTnf
otitis mediaTnf
Otitis Media with EffusionTnf
ovarian cancerPik3ca
Ovarian NeoplasmsAkt2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Socs1 , Socs2 , Tnf
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyAdipoq , Mapk8 , Tnf
PainTnf
pancreatic adenocarcinomaPik3ca
pancreatic agenesisPdx1
pancreatic cancerAkt2 , Ins2 , Mtor , Pdx1 , Tnf
pancreatic carcinomaMtor
pancreatic ductal carcinomaIns2 , Slc2a2
pancreatitisIkbkb , Ins2
Pancreatitis, Acute NecrotizingPdx1
Pancreatitis, Experimental, Acute Tnf
panic disorderIns2
paracoccidioidomycosisTnf
ParalysisIns2
ParesthesiaIns2
Parkinson's diseaseIns2 , Insr , Tnf
Parkinsonian DisordersAbcc8 , Kcnj11 , Mtor , Prkcd , Tnf
Paroxysmal Ventricular FibrillationCacna1c
Pediatric Crohn's DiseaseTnf
penile neoplasmPik3ca
peptic esophagitisTnf
Perennial Allergic RhinitisAdipoq
perinatal necrotizing enterocolitisTnf
periodontitisTnf
peripheral artery diseaseAdipoq
Peripheral Nerve InjuriesTnf
peripheral nervous system diseaseCacna1b , Prkce
peritonitisTnf
periventricular leukomalaciaTnf
permanent neonatal diabetes mellitusAbcc8 , Gck , Ins1 , Ins2 , Kcnj11 , Pdx1
Permanent Neonatal Diabetes Mellitus, with Neurologic FeaturesAbcc8 , Kcnj11
Picornaviridae InfectionsTnf
placenta diseaseTnf
placental insufficiencyPdx1
plasmacytomaPik3ca , Tnf
Plasmodium falciparum malariaTnf
pleomorphic xanthoastrocytomaGck
Pleural EffusionTnf
pleurisyTnf
Pneumococcal MeningitisTnf
Pneumococcal PneumoniaMapk1 , Mapk3 , Tnf
pneumoniaIkbkb , Tnf
Polycystic Kidney DiseasesMtor
polycystic ovary syndromeAdipoq , Akt2 , Ins2
PolymyositisTnf
portal hypertensionMtor , Pik3r1 , Prkcd
pre-eclampsiaTnf
pre-malignant neoplasmInsr , Irs1 , Mapk8 , Mapk9 , Socs4
precursor lymphoblastic lymphoma/leukemiaHk1
precursor T-lymphoblastic lymphoma/leukemiaMtor
prediabetes syndromeKcnj11 , Pdx1
Pregnancy Complications, CardiovascularTnf
Premature BirthTnf
PresbycusisCacna1d
Primary Aldosteronism, Seizures, and Neurologic AbnormalitiesCacna1d
primary hyperaldosteronismCacna1d
primary immunodeficiency diseaseCacna1c
primary open angle glaucomaAdipoq , Tnf
proliferative diabetic retinopathyAdipoq
prostate adenocarcinomaAkt2 , Ikbkb , Insr , Mapk1 , Pik3ca , Pik3cb
prostate cancerAkt2 , Cacna1d , Ikbkb , Ins2 , Mapk10 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2
prostate carcinomaAkt2
Prostatic NeoplasmsAdipoq , Ins2 , Insr , Irs1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkcz , Socs1 , Tnf
Pseudomonas InfectionsTnf
psoriasisIkbkb , Tnf
psoriatic arthritisTnf
PTEN hamartoma tumor syndromePik3ca
pulmonary edemaAdipoq , Tnf
pulmonary emphysemaAdipoq , Tnf
pulmonary fibrosisAdipoq , Tnf
pulmonary hypertensionAdipoq , Hk1 , Mtor , Slc2a4 , Tnf
pulmonary sarcoidosisTnf
pulmonary tuberculosisAdipoq , Tnf
Pyruvate Dehydrogenase E3-Binding Protein DeficiencyPdx1
pyruvate kinase deficiency of red cellsPklr
Radiation Injuries, ExperimentalMapk1 , Mapk3 , Tnf
Radiation PneumonitisTnf
radiculopathyTnf
rectal neoplasmMapk8 , Pik3ca , Pik3cb
relapsing polychondritisTnf
renal carcinomaMtor , Pik3ca
renal cell carcinomaInsr , Mapk1 , Mtor , Pik3ca , Pik3r1 , Tnf
renal fibrosisMapk1
renal hypertensionTnf
Reperfusion InjuryAdipoq , Mapk8 , Mapk9 , Pik3r1 , Pklr , Socs1 , Socs3 , Socs4 , Tnf
respiratory allergyTnf
respiratory syncytial virus infectious diseaseTnf
respiratory system diseaseTnf
Respiratory Tract InfectionsTnf
restrictive cardiomyopathyCacna1c , Prkcd
Retina Reperfusion InjuryTnf
retinal artery occlusionTnf
retinal detachmentTnf
retinal diseaseTnf
Retinal NeovascularizationMtor
retinitis pigmentosaHk1
RETINITIS PIGMENTOSA 79Hk1
RetrognathiaAbcc8
Rett syndromeAdipoq
RhabdomyolysisIns2
rheumatoid arthritisAdipoq , Tnf
rhinitisTnf
RhinosinusitisTnf
sarcomaPik3ca , Tnf
schizophreniaCacna1c , Mapk3 , Mtor , Pik3cb , Tnf
Schnyder corneal dystrophyMtor
sciatic neuropathyAbcc8 , Cacna1d , Kcnj11 , Mtor , Tnf
scleritisTnf
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaInsr
sensorineural hearing lossTnf
SepsisAdipoq , Irs1 , Mapk1 , Mapk3 , Mtor , Socs1 , Socs2 , Socs3 , Tnf
septic arthritisTnf
Septic PeritonitisPik3r1
Sezary's diseaseMapk1
ShockTnf
Shock, HemorrhagicMapk1 , Mtor , Tnf
short bowel syndromeInsr
short QT syndromeCacna1c
SHORT SyndromePik3r1
sick sinus syndromeCacna1d
sickle cell anemiaHk1 , Tnf
silicosisTnf
Silver-Russell syndromeIns1
Sinoatrial Node Dysfunction and DeafnessCacna1d
Sjogren's syndromeTnf
skin diseaseTnf
sleep apneaAdipoq
small cell carcinomaMtor , Tnf
Smith-Kingsmore SyndromeMtor
Smith-Magenis syndromeCacna1g , Socs3
Soft Tissue NeoplasmsTnf
Spinal Cord CompressionTnf
Spinal Cord InjuriesAbcc8 , Adipoq , Mtor , Socs2 , Tnf
Spinocerebellar Ataxia 42Cacna1g
spinocerebellar ataxia type 6Cacna1a
Spinocerebellar AtaxiasCacna1a , Cacna1g
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaMtor , Pik3ca
squamous cell carcinomaMapk1 , Mapk3 , Pik3ca
status epilepticusAbcc8 , Kcnj11 , Mtor , Socs3 , Tnf
Stevens-Johnson syndromeTnf
stomach cancerPik3ca
Stomach NeoplasmsIrs2 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Tnf
strabismusCacna1a
StrokeAbcc8 , Adipoq , Mapk8 , Pik3ca , Prkcd , Tnf
Subarachnoid HemorrhageAbcc8 , Adipoq , Tnf
Subarachnoid Hemorrhage, TraumaticAbcc8
substance-related disorderInsr , Prkce
Sudden Death, CardiacCacna1c
Systemic CandidiasisTnf
systemic lupus erythematosusAdipoq , Tnf
TachycardiaIns2 , Tnf
Tachycardia, SupraventricularCacna1d
Tachycardia, VentricularCacna1c
Telomeric 22q13 Monosomy SyndromeIns2
temporal lobe epilepsyCacna1a , Mtor
Temporomandibular Joint DisordersMtor , Tnf
thalassemiaTnf
thrombocytopeniaTnf
thrombosisPik3cb , Tnf
Thyroid NeoplasmsAkt2 , Pik3ca , Tnf
Timothy syndromeCacna1c
Tongue NeoplasmsTnf
tongue squamous cell carcinomaAdipoq
toxic encephalopathyMtor , Prkcd
toxic shock syndromeTnf
trachomaTnf
transient cerebral ischemiaIkbkb , Tnf
transient neonatal diabetes mellitusAbcc8 , Gck , Kcnj11
Transient Neonatal Diabetes Mellitus, 2Abcc8
Transient Neonatal Diabetes Mellitus, 3Kcnj11
transitional cell carcinomaMapk1 , Mtor , Pik3ca , Tnf
Transplant RejectionIkbkb , Tnf
trichinosisTnf
trigeminal neuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
tuberculosisTnf
type 1 diabetes mellitusAbcc8 , Adipoq , Ins2 , Kcnj11 , Pdx1 , Tnf
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusAbcc8 , Adipoq , Akt2 , Cacna1d , Gck , Hk1 , Hk2 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Kcnj11 , Mafa , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pdx1 , Pik3cb , Pik3r1 , Pklr , Prkce , Prkcz , Slc2a2 , Slc2a4 , Socs3 , Tnf
ulcerative colitisAdipoq , Tnf
ureteral obstructionMtor , Tnf
urethral obstructionMapk1
urinary bladder cancerHk1 , Mtor , Socs1 , Tnf
Urinary IncontinenceMapk1
urticariaTnf
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsMapk1 , Mtor , Pik3ca , Tnf
Uterine NeoplasmsMtor , Pik3ca , Pik3r1
uveitisTnf
vascular dementiaMtor
vascular diseaseAdipoq , Tnf
Vascular MalformationsPik3ca
Vascular System InjuriesTnf
velocardiofacial syndromeMapk1
Venous ThromboembolismTnf
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftIns2
Ventricular FibrillationIns2
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c
Ventricular Outflow ObstructionIns2
Viral BronchiolitisTnf
Viral Hepatitis, HumanAdipoq
viral pneumoniaTnf
visceral leishmaniasisTnf
visual epilepsyAbcc8 , Adipoq , Cacna1a , Ins2 , Kcnj11 , Pik3ca , Prkcd , Tnf
vitiligoPik3r1 , Tnf
Vogt-Koyanagi-Harada diseaseTnf
Vulvar VestibulitisTnf
Weight GainAdipoq , Pik3ca , Tnf
Weight LossAdipoq , Ins2
Weill-Marchesani syndromeTnf
Weissenbacher-Zweymuller syndromeMapk1
Wilson diseaseTnf
withdrawal disorderMapk1 , Mapk3
Wolff-Parkinson-White syndromeCacna1c , Cacna1e
Wounds and InjuriesTnf
Wounds, PenetratingTnf
Pathway Annotations Associated with Genes in the type 2 diabetes mellitus pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
acute myeloid leukemia pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
adenosine signaling pathwayIkbkb , Mapk1 , Mapk8 , Pik3ca , Prkcz
adiponectin signaling pathwayAdipoq
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
aldosterone signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
alfentanil pharmacodynamics pathwayCacna1a
allograft rejection pathwayTnf
altered galactose metabolic pathwayHk2
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin secretion pathwayAbcc8 , Kcnj11
altered insulin signaling pathwayIns2 , Insr
altered leptin system pathwayInsr
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt2 , Pik3ca
Alzheimer's disease pathwayCacna1c , Cacna1d , Mapk1 , Mapk3 , Tnf
amino sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
amiodarone pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
amlodipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
amyotrophic lateral sclerosis pathwayTnf
angiotensin II signaling pathwayPrkcz
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAkt2 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
arrhythmogenic right ventricular cardiomyopathy pathwayCacna1c , Cacna1d
asthma pathwayTnf
atenolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
betaxolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
bisoprolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Bone morphogenetic proteins signaling pathwayMapk1
bupivacaine pharmacodynamics pathwayCacna1a
bupranolol drug pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
bupranolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
buprenorphine pharmacodynamics pathwayCacna1a
butirosin and neomycin biosynthetic pathwayGck , Hk1 , Hk2 , Hk3
c-Jun N-terminal kinases MAPK signaling pathwayMapk10 , Mapk8 , Mapk9
calcium transport pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
calcium/calcium-mediated signaling pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c
carvedilol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
ceramide signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz , Tnf
Chagas disease pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
chemokine mediated signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz
chloroprocaine pharmacodynamics pathwayCacna1a
chronic myeloid leukemia pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
citalopram pharmacodynamics pathwayCacna1a
cocaine pharmacodynamics pathwayCacna1a
codeine and morphine pharmacodynamics pathwayCacna1a
colorectal cancer pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
congenital sucrase-isomaltase deficiency pathwayGck , Hk2
cytokine mediated signaling pathwayTnf
desipramine pharmacodynamics pathwayCacna1a
diabetes mellitus pathwayAbcc8
dilated cardiomyopathy pathwayCacna1c , Cacna1d , Tnf
diltiazem pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
diphenoxylate pharmacodynamics pathwayCacna1a
disopyramide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
dobutamine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
E-cadherin signaling pathwayAkt2 , Pik3ca , Pik3r1
eicosanoid signaling pathwayPik3r5 , Prkcd , Prkce , Prkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaAdipoq
endocytosis pathwayPrkcz
endometrial cancer pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayMapk1 , Mapk3 , Mapk8 , Prkcd , Prkce
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
ephrin - ephrin receptor bidirectional signaling axisMapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcz
erythropoietin signaling pathwayIrs2 , Mapk8 , Pik3r1 , Socs3
escitalopram pharmacodynamics pathwayCacna1a
esmolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
ethylmorphine pharmacodynamics pathwayCacna1a
facilitative sugar transporter mediated glucose transport pathwaySlc2a2 , Slc2a4
Fanconi syndrome pathwayHk2 , Pklr , Slc2a2
FasL mediated signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce , Tnf
Fc gamma receptor mediated signaling pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce
felodipine pharmacokinetics pathwayCacna1c
fentanyl pharmacodynamics pathwayCacna1a
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
fluoxetine pharmacodynamics pathwayCacna1a
forkhead class A signaling pathwayAbcc8 , Gck , Ins2 , Kcnj11 , Pdx1 , Pklr , Slc2a2
fosphenytoin pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
french type sialuria pathwayHk1
fructose and mannose metabolic pathwayHk1 , Hk2 , Hk3
fructose-1,6-bisphosphatase deficiency pathwayHk2 , Slc2a2
fructosuria pathwayHk1
galactokinase deficiency pathwayGck
galactose metabolic pathwayGck , Hk1 , Hk2 , Hk3
galactosemia pathwayGck , Hk1
GALE deficiency pathwayGck
gliclazide pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
glioma pathwayAkt2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
gluconeogenesis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr , Slc2a2
glutamate signaling pathwayCacna1a , Cacna1c , Cacna1d , Mapk1 , Mapk3
glyburide pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
glycogen biosynthetic pathwayGck
glycogen metabolic pathwayGck
glycogen storage disease type Ia pathwayHk2 , Slc2a2
glycogen storage disease type Ib pathwayHk2 , Slc2a2
glycogen storage disease type III pathwayGck , Hk2
glycogen storage disease type IV pathwayGck , Hk2
glycogen storage disease type VI pathwayGck , Hk2
glycogen storage disease type VII pathwayHk2 , Pklr , Slc2a2
glycolysis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr , Slc2a2
glycolysis/gluconeogenesis pathwayGck , Hk1 , Hk2 , Hk3 , Pklr
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayCacna1c , Cacna1d , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Prkcd
graft-versus-host disease pathwayTnf
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Mapk1 , Mapk3 , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1 , Prkcd
hepatitis C pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Tnf
hereditary fructose intolerance syndrome pathwayHk1
heroin pharmacodynamics pathwayCacna1a
hydrocodone pharmacodynamics pathwayCacna1a
hydromorphone pharmacodynamics pathwayCacna1a
hypertrophic cardiomyopathy pathwayCacna1c , Cacna1d , Tnf
hypoxia inducible factor pathwayGck , Hk1 , Hk2
ibutilide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
imipramine pharmacodynamics pathwayCacna1a
inflammatory response pathwayMapk8
influenza A pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs3 , Tnf
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2 , Ins2 , Insr , Prkcz , Slc2a4
insulin secretion pathwayAbcc8 , Cacna1a , Cacna1c , Cacna1d , Gck , Kcnj11 , Slc2a2
insulin signaling pathwayAkt2 , Gck , Hk1 , Hk2 , Hk3 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pklr , Prkcz , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4
insulin-like growth factor signaling pathwayIrs1 , Irs2 , Irs4 , Pik3ca , Pik3r1 , Prkcd , Prkcz
interleukin-1 signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkcz
interleukin-12 signaling pathwayMtor , Socs1
interleukin-2 signaling pathwayIrs1 , Irs2 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Prkce , Socs1 , Socs2 , Socs3
interleukin-23 signaling pathwayPik3ca , Pik3r1 , Socs3 , Tnf
interleukin-27 signaling pathwayTnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayIrs1 , Irs2 , Mtor , Pik3ca , Pik3r1 , Socs1 , Socs3
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayPik3ca , Pik3r1 , Prkcd , Socs3
isoprenaline pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
isradipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Jak-Stat signaling pathwayAkt2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Socs2 , Socs3 , Socs4
lactose degradation pathwaySlc2a2
Leigh disease pathwayPklr
Leishmaniasis pathwayMapk1 , Mapk3 , Tnf
leptin system pathwayIrs1 , Irs2 , Socs3
levacetylmethadol pharmacodynamics pathwayCacna1a
levobunolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
levobupivacaine phgarmacodynamics pathwayCacna1a
levorphanol pharmacodynamics pathwayCacna1a
lidocaine pharmacodynamics pathwayAbcc8 , Cacna1a , Cacna1c , Cacna1g , Kcnj11
long term depressionCacna1a , Mapk1 , Mapk3
long term potentiationCacna1c , Mapk1 , Mapk3
malaria pathwayTnf
maturity-onset diabetes of the young pathwayGck , Ins1 , Ins2 , Mafa , Pdx1 , Pklr , Slc2a2
measles pathwayAkt2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mepivacaine pharmacodynamics pathwayCacna1a
methadone pharmacodynamics pathwayCacna1a
metoprolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
mexiletine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
mitogen activated protein kinase signaling pathwayAkt2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
mTOR signaling pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
nadolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nalbuphine pharmacodynamics pathwayCacna1a
naloxone pharmacodynamics pathwayCacna1a
naltrexone pharmacodynamics pathwayCacna1a
nebivolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
neurotrophic factor signaling pathwayAkt2 , Ikbkb , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd
nicotine pharmacodynamics pathwayCacna1a
nifedipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nimodipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nisoldipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
nitrendipine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
NOD-like receptor signaling pathwayIkbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
non-small cell lung carcinoma pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nuclear factor kappa B signaling pathwayIkbkb , Pik3ca , Pik3r1 , Tnf
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
nucleotide sugar metabolic pathwayGck , Hk1 , Hk2 , Hk3
oxybuprocaine pharmacodynamics pathwayCacna1a
oxycodone pharmacodynamics pathwayCacna1a
oxymorphone pharmacodynamics pathwayCacna1a
p53 signaling pathwayMapk8 , Mapk9 , Prkcd
pancreatic cancer pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
penbutolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
pentazocine pharmacodynamics pathwayCacna1a
phenytoin pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt2 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Slc2a4
phosphoenolpyruvate carboxykinase deficiency pathwayHk2 , Slc2a2
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
platelet-derived growth factor signaling pathwayMapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkce
potassium channel inhibitors pharmacodynamics pathwayAbcc8 , Cacna1a , Ins2 , Slc2a2
prilocaine pharmacodynamics pathwayCacna1a
primary hyperoxaluria type 2 pathwayPklr
prion disease pathwayMapk1 , Mapk3
procainamide pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
procaine pharmacodynamics pathwayCacna1a
propranolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
prostate cancer pathwayAkt2 , Ikbkb , Ins1 , Ins2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
protein kinase C (PKC) signaling pathwayPrkcd , Prkce , Prkcz
purine metabolic pathwayPklr
pyruvate decarboxylase deficiency pathwayPklr
pyruvate dehydrogenase E1 deficiency pathwayPklr
pyruvate kinase deficiency of red cells pathwayPklr
pyruvate metabolic pathwayPklr
quinidine pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
remifentanil pharmacodynamics pathwayCacna1a
renal cell carcinoma pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb , Mapk10 , Mapk8 , Mapk9 , Tnf
rheumatoid arthritis pathwayTnf
Rho/Rac/Cdc42 mediated signaling pathwayMapk8
ropivacaine pharmacodynamics pathwayCacna1a
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sialic acid storage disease pathwayHk1
sleeping sickness pathwayTnf
small cell lung carcinoma pathwayAkt2 , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
sotalol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
sphingosine 1-phosphate signaling pathwayIrs1 , Mapk1 , Mapk3 , Mapk8
starch and sucrose metabolic pathwayGck , Hk1 , Hk2 , Hk3
syndecan signaling pathwayMapk1 , Mapk3 , Mapk8 , Prkcd
systemic lupus erythematosus pathwayTnf
T cell receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk3 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
Tay-Sachs disease pathwayHk1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMapk1 , Mapk3 , Prkcd
thyroid cancer pathwayMapk1 , Mapk3
timolol pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Toll-like receptor signaling pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
toxoplasmosis pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Socs1 , Tnf
Trail mediated signaling pathwayIkbkb , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tramadol pharmacodynamics pathwayCacna1a
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Tnf
trehalose degradation pathwayGck , Slc2a2
triosephosphate isomerase deficiency pathwayHk2 , Slc2a2
tuberculosis pathwayAkt2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Tnf
tumor necrosis factor mediated signaling pathwayIkbkb , Prkcz , Tnf
type 1 diabetes mellitus pathwayIns1 , Ins2 , Tnf
type 2 diabetes mellitus pathwayAbcc8 , Adipoq , Akt2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Gck , Hk1 , Hk2 , Hk3 , Ikbkb , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kcnj11 , Mafa , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Mtor , Pdx1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pklr , Prkcd , Prkce , Prkcz , Slc2a2 , Slc2a4 , Socs1 , Socs2 , Socs3 , Socs4 , Tnf
type II interferon signaling pathwayMapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Prkcd , Socs1
ubiquitin/proteasome degradation pathwaySocs1 , Socs3
urinary bladder cancer pathwayMapk1 , Mapk3
vascular endothelial growth factor signaling pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcd , Prkcz
verapamil pharmacodynamics pathwayAbcc8 , Cacna1c , Cacna1g , Kcnj11
Wnt signaling pathwayMapk10 , Mapk8 , Mapk9
Wnt signaling, non-canonical pathwayMapk10 , Mapk8 , Mapk9 , Prkcz
Phenotype Annotations Associated with Genes in the type 2 diabetes mellitus pathway

References Associated with the type 2 diabetes mellitus pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: