NOTCH SIGNALING PATHWAY (PW:0000204)

View Ontology Report

Description

Notch signaling, a highly conserved cell-cell signaling pathway, exerts an essential regulatory role in gene expression and controls cell fate determination, differentiation, and proliferation. Notch receptors and ligands, four and five respectively in mammals, are single transmembrane proteins connecting the cell-receiving and the cell-sending signal. The DSL domain of Dll/Jag ligands and the EGF-like repeats of Notch receptors mediate the interaction. The journey of Notch from transmembrane re

Pathway Diagram:

Ariadne Genomics Inc. Jag_ligands ---- Notch_receptors Jag_ligands Hey ---> regulation of transcription Maml Fng Rbpj ---> Hey Rbpj ---> Hes Hey Hes Rbpj gamma-convertase Notch_receptors Dll_ligands NICD gamma-convertase --+> Notch_receptors Notch_receptors ---> NICD Dll_ligands ---- Notch_receptors Adam10 --+> Notch_receptors Adam17 --+> Notch_receptors Fng --+> Notch_receptors Pofut1 --+> Notch_receptors Hes ---> regulation of transcription regulation of transcription Adam10 Adam17 Pofut1
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
Notch signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:1300252
RGD:6484113
RGD:2302204
G Adam12 ADAM metallopeptidase domain 12 JBrowse link 1 205,951,840 206,286,294 RGD:6484113
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:2302204
RGD:6907045
G Aph1a aph-1 homolog A, gamma secretase subunit JBrowse link 2 198,006,247 198,009,837 RGD:2302204
RGD:6907045
RGD:6484113
G Aph1b aph-1 homolog B, gamma secretase subunit JBrowse link 8 72,508,008 72,598,921 RGD:2302204
RGD:6907045
RGD:6484113
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:6484113
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6484113
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6484113
G Cir1 corepressor interacting with RBPJ, 1 JBrowse link 3 59,994,547 60,023,843 RGD:6907045
G Cntn1 contactin 1 JBrowse link 7 133,290,606 133,588,314 RGD:6484113
G Cntn6 contactin 6 JBrowse link 4 136,512,201 136,904,355 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Ctbp1 C-terminal binding protein 1 JBrowse link 14 82,762,109 82,789,350 RGD:6484113
RGD:6907045
G Ctbp2 C-terminal binding protein 2 JBrowse link 1 205,001,354 205,030,565 RGD:6907045
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:6484113
G Dlk1 delta like non-canonical Notch ligand 1 JBrowse link 6 133,576,513 133,583,751 RGD:6484113
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1304491
RGD:6907045
RGD:6484113
RGD:2302204
G Dll3 delta like canonical Notch ligand 3 JBrowse link 1 85,485,875 85,493,683 RGD:1304491
RGD:6907045
RGD:6484113
RGD:2302204
G Dll4 delta like canonical Notch ligand 4 JBrowse link 3 111,135,011 111,146,746 RGD:2302204
RGD:6907045
RGD:6484113
G Dner delta/notch-like EGF repeat containing JBrowse link 9 91,965,866 92,291,172 RGD:6484113
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:6484113
G Dtx2 deltex E3 ubiquitin ligase 2 JBrowse link 12 23,687,958 23,727,594 RGD:6907045
G Dtx3 deltex E3 ubiquitin ligase 3 JBrowse link 7 70,476,737 70,482,852 RGD:6907045
G Dtx3l deltex E3 ubiquitin ligase 3L JBrowse link 11
11
67,758,093
67,768,542
67,767,623
67,772,428
RGD:6907045
G Dtx4 deltex E3 ubiquitin ligase 4 JBrowse link 1 228,729,842 228,759,783 RGD:6907045
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:6907045
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:6907045
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6484113
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6484113
RGD:6907045
G Eps15 epidermal growth factor receptor pathway substrate 15 JBrowse link 5 128,923,809 129,022,268 RGD:6484113
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:6484113
G Furin furin (paired basic amino acid cleaving enzyme) JBrowse link 1 142,185,092 142,198,167 RGD:6484113
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6484113
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6484113
RGD:6907045
G Hdac1l histone deacetylase 1-like JBrowse link 9 84,893,145 84,894,599 RGD:6907045
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6907045
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:5135539
RGD:6907045
G Hes5 hes family bHLH transcription factor 5 JBrowse link 5 172,364,421 172,365,188 RGD:5135539
RGD:6907045
G Hes7 hes family bHLH transcription factor 7 JBrowse link 10 55,704,485 55,710,523 RGD:5135539
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:70528
RGD:5135539
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 JBrowse link 1 29,191,170 29,201,257 RGD:5135539
RGD:70528
G Heyl hes-related family bHLH transcription factor with YRPW motif-like JBrowse link 5 140,923,914 140,940,905 RGD:5135539
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6484113
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:6484113
G Jag1 jagged 1 JBrowse link 3 130,079,361 130,114,781 RGD:69863
RGD:6907045
RGD:6484113
RGD:1334443
RGD:2302204
G Jag2 jagged 2 JBrowse link 6 137,711,144 137,733,331 RGD:69864
RGD:6907045
RGD:6484113
RGD:2302204
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:6907045
G Kat2b lysine acetyltransferase 2B JBrowse link 9 4,440,982 4,492,949 RGD:6907045
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:6484113
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 12 16,117,767 16,126,211 RGD:727405
RGD:6907045
RGD:2302204
G Lnx1 ligand of numb-protein X 1 JBrowse link 14 36,047,136 36,149,740 RGD:6484113
G Maml1 mastermind-like transcriptional coactivator 1 JBrowse link 10 35,765,196 35,801,375 RGD:2302204
RGD:6907045
RGD:6484113
G Maml2 mastermind-like transcriptional coactivator 2 JBrowse link 8 11,929,238 12,253,991 RGD:2302204
RGD:6907045
RGD:6484113
G Maml3 mastermind-like transcriptional coactivator 3 JBrowse link 2 140,734,138 141,276,886 RGD:2302204
G Mark2 microtubule affinity regulating kinase 2 JBrowse link 1 222,525,547 222,590,727 RGD:6484113
G Mfap2 microfibril associated protein 2 JBrowse link 5 159,534,202 159,539,750 RGD:6484113
G Mfap5 microfibril associated protein 5 JBrowse link 4 155,313,671 155,336,228 RGD:6484113
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 7 119,978,981 119,996,824 RGD:1302739
RGD:6907045
RGD:2302204
G Mib1 mindbomb E3 ubiquitin protein ligase 1 JBrowse link 18 1,970,914 2,094,920 RGD:1334454
RGD:6484113
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6484113
G Mycbp Myc binding protein JBrowse link 5 141,560,192 141,567,399 RGD:6484113
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:6484113
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6484113
RGD:6907045
G Ncstn nicastrin JBrowse link 13 90,451,046 90,467,256 RGD:724403
RGD:6907045
RGD:6484113
RGD:2302204
G Neurl1 neuralized E3 ubiquitin protein ligase 1 JBrowse link 1 266,953,006 267,038,879 RGD:1334462
G Neurl2 neuralized E3 ubiquitin protein ligase 2 JBrowse link 3 161,296,303 161,299,024 RGD:1334462
G Notch1 notch 1 JBrowse link 3 3,905,562 3,951,015 RGD:724389
RGD:6907045
RGD:6484113
RGD:2306423
RGD:1334443
RGD:2302204
RGD:1358543
G Notch2 notch 2 JBrowse link 2 200,187,184 200,320,403 RGD:69906
RGD:6907045
RGD:6484113
RGD:2302204
G Notch3 notch 3 JBrowse link 7 14,138,495 14,189,688 RGD:625426
RGD:6907045
RGD:6484113
RGD:2306423
RGD:2302204
G Notch4 notch 4 JBrowse link 20 4,329,794 4,353,868 RGD:1304484
RGD:6907045
RGD:6484113
RGD:2302204
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:724390
RGD:6907045
RGD:6484113
G Numbl NUMB-like, endocytic adaptor protein JBrowse link 1 84,067,841 84,091,659 RGD:1334451
RGD:6907045
G Pofut1 protein O-fucosyltransferase 1 JBrowse link 3 148,722,864 148,749,743 RGD:1334453
RGD:2302204
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:724403
RGD:6907045
RGD:6484113
RGD:2302204
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:2302204
RGD:6907045
G Psenen presenilin enhancer gamma secretase subunit JBrowse link 1 89,016,093 89,017,449 RGD:2302204
RGD:6907045
RGD:6484113
G Ptcra pre T-cell antigen receptor alpha JBrowse link 9 16,528,970 16,539,383 RGD:6907045
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:6484113
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:6484113
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 14 59,657,738 59,865,427 RGD:2306423
RGD:6907045
RGD:6484113
G Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like JBrowse link 3 160,851,836 160,865,125 RGD:6907045
G Rbpjl2 recombination signal binding protein for immunoglobulin kappa J region-like 2 JBrowse link 5 4,877,924 4,879,637 RGD:6907045
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase JBrowse link 10 109,963,726 109,966,821 RGD:633801
RGD:6907045
RGD:2302204
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:6484113
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:6484113
G Snw1 SNW domain containing 1 JBrowse link 6 111,483,698 111,507,782 RGD:6907045
G Spen spen family transcriptional repressor JBrowse link 5 160,015,573 160,070,915 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:6484113
altered Notch signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1304492
G Dll3 delta like canonical Notch ligand 3 JBrowse link 1 85,485,875 85,493,683 RGD:1304493
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1334460
G Jag1 jagged 1 JBrowse link 3 130,079,361 130,114,781 RGD:1304484
G Jag2 jagged 2 JBrowse link 6 137,711,144 137,733,331 RGD:1304492
G Notch1 notch 1 JBrowse link 3 3,905,562 3,951,015 RGD:724389
G Notch2 notch 2 JBrowse link 2 200,187,184 200,320,403 RGD:69906
G Notch4 notch 4 JBrowse link 20 4,329,794 4,353,868 RGD:1304484
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:1334451
G Pofut1 protein O-fucosyltransferase 1 JBrowse link 3 148,722,864 148,749,743 RGD:1334453
altered Notch signaling pathway involving promoters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1334460
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:1334451
G Pofut1 protein O-fucosyltransferase 1 JBrowse link 3 148,722,864 148,749,743 RGD:1334453
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:2302525
altered Notch signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll3 delta like canonical Notch ligand 3 JBrowse link 1 85,485,875 85,493,683 RGD:1304493
G Jag1 jagged 1 JBrowse link 3 130,079,361 130,114,781 RGD:1334443
G Notch1 notch 1 JBrowse link 3 3,905,562 3,951,015 RGD:1334450
G Notch3 notch 3 JBrowse link 7 14,138,495 14,189,688 RGD:1334442

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Complexgamma-convertasea multiprotein protease complex containing Psen1 or 2, Aph1, Ncstn and Psenen
Functional ClassDll_ligandsdelta-like Notch ligands
Functional ClassFngfringe 3-beta-N-acetylglucosaminyltransferase members
Functional ClassJag_ligandsJagged Notch ligands
Functional ClassMamlmastermind-like family members
Functional ClassNotch_receptorsNotch family members

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Notch signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociMyc
acoustic neuromaCdkn1a
Acute Coronary SyndromeEno1
Acute HepatitisIl4
acute kidney failureHdac2 , Hes1 , Myc
Acute Lung InjuryIl4
acute lymphocytic leukemiaNotch3
acute myeloid leukemiaCbl , Ccnd1 , Crebbp , Myc
acute promyelocytic leukemiaMyc
Acute-Phase ReactionNcor1
Adams-Oliver syndromeDll4 , Notch1 , Rbpj
Adams-Oliver Syndrome 3Rbpj
Adams-Oliver Syndrome 5Notch1
Adams-Oliver Syndrome 6Dll4
adenocarcinomaCcnd1 , Eno1 , Myc
adenoid cystic carcinomaCcnd1 , Cntn6 , Crebbp , Dtx4 , Ep300 , Fbxw7 , Jag1 , Maml3 , Mark2 , Mycbp , Notch1
adenosine deaminase deficiencyJag1
adult T-cell leukemiaGata3 , Il4 , Notch1
AIDS-Associated NephropathyNotch4
Alagille syndromeJag1 , Notch2
alcohol use disorderHdac2
allergic contact dermatitisIl4
allergic hypersensitivity diseaseIl4
allergic rhinitisIl4
alopecia areataHdac1 , Hdac2 , Kdm1a , Notch4
alopecia universalisIl4
Alzheimer's diseaseCrebbp , Dnm1 , Eno1 , Ep300 , Hdac2 , Il4 , Ncstn , Psen1 , Psen2
Alzheimer's disease 18Adam10
Alzheimer's disease 3Psen1
Alzheimer's disease 4Psen1 , Psen2
Alzheimer's Disease, Familial, 3, with Spastic ParaparesisPsen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and ApraxiaPsen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual PlaquesPsen1
amyloidosisPsen1
amyotrophic lateral sclerosisHes1 , Hey1 , Jag1 , Maml1 , Notch1
amyotrophic lateral sclerosis type 1Crebbp
AnaphylaxisIl4
angiosarcomaCcnd1 , Myc
Animal Disease ModelsEno1 , Myc , Psen1
anogenital venereal wartIl4
anti-basement membrane glomerulonephritisIl4
anxiety disorderHdac2 , Ncor1
aortic valve diseaseHey2 , Notch1
Aortic Valve Disease 1Notch1
Aortic Valve Disease 2Notch1
aortic valve stenosisNotch1
Aortic Valve, Calcification ofNotch1
Arsenic PoisoningCdkn1a
ARTERIAL DISSECTIONNotch1
arteriosclerosisFurin , Notch4
arteriovenous malformations of the brainNotch4
asphyxia neonatorumPsen1 , Psen2
Aspirin-Induced AsthmaIl4
asthmaGata3 , Hdac2 , Il4
astrocytomaCcnd1 , Dll3 , Hey1 , Hey2 , Notch1 , Notch2
AtaxiaCntn1
atopic dermatitisIl4
atrial fibrillationCdkn1a
attention deficit hyperactivity disorderCrebbp
autism spectrum disorderHey1
autistic disorderCrebbp , Il4
Autoimmune DiseasesIl4
autoimmune hepatitisIl4
autoimmune thrombocytopenic purpuraIl4
autoimmune thyroiditisIl4
autosomal dominant polycystic kidney diseaseCdkn1a , Myc
autosomal dominant Robinow syndrome 1Dvl1
autosomal dominant Robinow syndrome 2Dvl1 , Dvl3
autosomal dominant Robinow syndrome 3Dvl3
autosomal recessive limb-girdle muscular dystrophy type 2AJag1
autosomal recessive limb-girdle muscular dystrophy type 2BJag1
autosomal recessive limb-girdle muscular dystrophy type 2LJag1
autosomal recessive nonsyndromic deafness 9Jag1
autosomal recessive polycystic kidney diseaseMyc
Autosomal Recessive Spinocerebellar Ataxia 8Jag1
B-Cell LeukemiaMyc
Barrett's esophagusCdkn1a
basal cell carcinomaFbxw7
Behcet's diseaseIl4
Bicuspid Aortic ValveNotch1
biliary atresiaDlk1
biliary tract neoplasmIl4
bladder urothelial carcinomaCrebbp , Ep300 , Fbxw7
BlisterAdam17
body dysmorphic disorderHdac2
bone diseaseJag1
Bowen's DiseaseCdkn1a
Brain HypoxiaEp300
Brain InjuriesCdkn1a , Il4 , Skp2 , Snw1
Brain NeoplasmsCcnd1 , Dll1 , Dtx2 , Hes5
breast cancerFbxw7 , Myc
Breast Cancer, FamilialNcor1
breast ductal carcinomaNotch3 , Spen
Breast NeoplasmsAdam10 , Ccnd1 , Cdkn1a , Dll1 , Dll4 , Dtx3 , Eno1 , Ep300 , Fbxw7 , Hdac1 , Hes1 , Hey1 , Hey2 , Heyl , Jag1 , Jag2 , Kat2b , Kdm1a , Myc , Ncor1 , Ncor2 , Notch1 , Notch2 , Notch3 , Notch4 , Psen2 , Skp2 , Snw1
Bronchial HyperreactivityGata3
bronchiolitis obliteransIl4
bronchiolo-alveolar adenocarcinomaCcnd1
bronchitisHdac2
Brugada syndromeHey2
Burkitt lymphomaMyc
BurnsCcnd1
CADASILNotch3
CADASIL 1Notch3
calcinosisNotch1
carcinomaCcnd1 , Cdkn1a , Eno1 , Furin , Gata3 , Myc
cardiac arrestEp300
CardiomegalyEp300 , Hdac2 , Myc , Yy1
cardiomyopathyEp300 , Il4 , Psen1
Cardiomyopathy, Hypertrophic, FamilialMib1
Carotid Artery InjuriesCbl , Hey1 , Hey2 , Heyl , Jag1 , Myc , Notch1 , Notch2 , Notch3
carotid stenosisIl4
Cecal NeoplasmsCcnd1
Cell Transformation, NeoplasticCcnd1 , Ctbp2 , Myc , Notch1
central nervous system diseaseCrebbp
cerebellar ataxiaDnm1
cerebral amyloid angiopathyPsen1
Cerebral HemorrhagePsen1
cerebral infarctionNotch3
cervix uteri carcinoma in situCcnd1 , Cdkn1a , Hdac1 , Hdac2 , Skp2
Chemical and Drug Induced Liver InjuryEno1 , Il4
ChloracneRab11a
cholangiocarcinomaNotch1
cholestasisIl4
cholesteatoma of middle earCdkn1a
Cholesteatoma, CongenitalCdkn1a
Chromosome BreakageIl4 , Myc
chronic lymphocytic leukemiaFbxw7 , Myc
Chronic Lymphocytic Leukemia, B-CellCbl , Fbxw7
chronic myeloid leukemiaHes1 , Ncstn
chronic obstructive pulmonary diseaseHdac2
clear cell renal cell carcinomaEp300 , Myc
cleft lipMyc
cleft palateMyc
Cleft Palate, Psychomotor Retardation, and Distinctive Facial FeaturesKdm1a
Cognition DisordersHdac2 , Il4 , Psen1
Cognitive DysfunctionPsen1
colitisAdam17 , Il4
colon carcinomaEp300
Colonic NeoplasmsCcnd1 , Cdkn1a , Hdac1 , Hdac2 , Hes1 , Kdm1a , Myc , Notch1
Colonic PolypsHdac2
colorectal adenocarcinomaCdkn1a
colorectal cancerEp300
Colorectal NeoplasmsCcnd1 , Crebbp , Ctbp1 , Ep300 , Fbxw7 , Neurl1
common coldIl4
Compton-North congenital myopathyCntn1
Congenital AbnormalitiesDll3 , Notch1
Congenital Generalized FibromatosisNotch3
congenital heart diseaseJag1 , Maml3 , Notch1
congenital merosin-deficient muscular dystrophy 1AJag1
congenital myasthenic syndrome 10Jag1
congestive heart failureCbl , Ep300 , Yy1
contact dermatitisIl4
Corneal OpacityJag1
Coronary DiseaseKat2b
coronary restenosisMyc
Craniofacial AbnormalitiesDll3 , Ep300 , Jag2 , Notch1
Critical IllnessKdm1a
cryptorchidismCbl
Currarino TriadDvl3
cutaneous leishmaniasisIl4
Cutaneous Malignant Melanoma, Susceptibility To, 1Cbl , Fbxw7
cutaneous T cell lymphomaIl4
cystitisIl4
DeafnessJag1
Deafness, Congenital Heart Defects, and Posterior EmbryotoxonJag1
dementiaNotch4
demyelinating diseaseHdac1 , Myc
dermatomyositisIl4
Developmental DisabilitiesCbl , Ep300 , Ncor1
Diabetic NephropathiesCdkn1a , Ep300 , Hdac2
diabetic retinopathyEp300 , Kdm1a
Diamond-Blackfan anemiaHes7
diffuse large B-cell lymphomaSkp2
DiGeorge syndromeDvl1
dilated cardiomyopathyPsen1 , Psen2 , Rbpj
dilated cardiomyopathy 1GJag1
dilated cardiomyopathy 1UPsen1
dilated cardiomyopathy 1VPsen2
disease of cellular proliferationMyc , Skp2 , Yy1
disease of mental healthDvl1
Disease ProgressionKdm1a , Myc , Yy1
Dog DiseasesDnm1
Dowling-Degos diseaseAdam10 , Pofut1
Dowling-Degos Disease 2Pofut1
drug allergyIl4
Drug EruptionsIl4
ductal carcinoma in situCcnd1 , Cdkn1a , Notch4
dysostosisDll3
Early Infantile Epileptic Encephalopathy, 31Dnm1
EdemaIl4
end stage renal failureGata3
Endometrial HyperplasiaSkp2
Endometrial NeoplasmsCcnd1 , Cdkn1a , Ep300 , Fbxw7 , Hdac1 , Hdac2 , Jag1 , Myc , Ncor2 , Notch1 , Notch4 , Skp2
endometriosisHdac1 , Hdac2 , Ncor1 , Rbpj
EndotoxemiaEp300
EosinophiliaGata3
epilepsyHes1
esophageal carcinomaEp300 , Fbxw7 , Myc
Esophageal NeoplasmsCcnd1 , Cdkn1a , Eno1 , Ep300 , Fbxw7 , Myc
esophagus squamous cell carcinomaCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Kat2b , Notch1 , Notch2 , Notch3
Experimental ArthritisCbl , Il4 , Jag1
Experimental Autoimmune EncephalomyelitisAdam17 , Dll1 , Il4 , Jag1
Experimental Autoimmune UveoretinitisIl4
Experimental Diabetes MellitusCdkn1a , Ep300 , Furin , Hdac1 , Hdac2 , Il4 , Myc
Experimental Liver CirrhosisAdam17 , Cdkn1a , Myc , Ncor2
Experimental NeoplasmsCcnd1
Eye AbnormalitiesJag1
FaciesJag1
facioscapulohumeral muscular dystrophyCdkn1a
familial adenomatous polyposisHdac2
Familial Hidradenitis SuppurativaNcstn , Psen1 , Psenen
familial Mediterranean feverJag1
Familial Thoracic Aortic Aneurysm 9Mfap5
fatty liver diseaseMyc
Fetal Growth RetardationDlk1 , Hdac1 , Hdac2
FibrosisIl4
follicular lymphomaCrebbp
frontotemporal dementiaPsen1
Fuchs' endothelial dystrophyCdkn1a
GABRIELE-DE VRIES SYNDROMEYy1
gangliosidosis GM1Jag1
gastric adenocarcinomaCrebbp , Fbxw7
Gaucher's diseaseIl4
genetic diseaseCbl , Crebbp , Ctbp1 , Dll4 , Dnm1 , Dvl1 , Ep300 , Gata3 , Hdac1 , Hdac2 , Jag1 , Notch1 , Notch2 , Notch3 , Rbpj , Yy1
Genomic InstabilityCcnd1 , Fbxw7
glaucomaCrebbp
glioblastoma multiformeCrebbp , Fbxw7 , Hes1 , Hey1 , Jag1 , Jag2 , Myc , Ncor1 , Notch1 , Notch2 , Notch3
glomerulonephritisEp300
GranulomaIl4
Growth DisordersCbl
growth hormone secreting pituitary adenomaCdkn1a
Hajdu-Cheney syndromeNotch2
head and neck squamous cell carcinomaCcnd1 , Crebbp , Ep300 , Fbxw7
Hearing Loss, Noise-InducedCdkn1a , Cntn1
heart diseaseEp300 , Hdac1
heart valve diseaseNotch1
Hematologic NeoplasmsCbl
hepatitis BKat2a
hepatocellular carcinomaCcnd1 , Cdkn1a , Crebbp , Eno1 , Ep300 , Hdac2 , Kat2b , Kdm1a , Myc , Skp2 , Snw1
Hereditary Neoplastic SyndromesIl4 , Skp1
Hernias, Diaphragmatic, CongenitalCbl , Ep300
herpes zosterIl4
hidradenitis suppurativaNcstn , Psen1 , Psenen
Hirschsprung Disease 1Crebbp , Notch2
HirsutismEp300
Hodgkin's lymphomaGata3
holoprosencephalyDll1
holoprosencephaly 1Dll1
human immunodeficiency virus infectious diseaseCdkn1a , Yy1
Human InfluenzaIl4
Huntington's diseaseCrebbp , Ep300 , Hdac1 , Ncor1
HyperalgesiaEp300
Hyperbilirubinemia, NeonatalNcor1
hyperglycemiaCbl
HyperoxiaCdkn1a
HyperparathyroidismCcnd1 , Myc
HyperplasiaCcnd1 , Cdkn1a , Kdm1a
Hypersensitivity, DelayedGata3
Hypersensitivity, ImmediateIl4
hypertensionEno1 , Ep300
hypertrophic cardiomyopathyHey2 , Myc , Yy1
hypertrophic cardiomyopathy 9Jag1
HypertrophyCdkn1a
Hypertrophy, Left VentricularMyc
Hypertrophy, Right VentricularHdac1
hypoparathyroidismGata3
hypoparathyroidism-deafness-renal disease syndromeGata3
hypothyroidismNcor1
HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROMECtbp1
HypovolemiaCdkn1a
idiopathic generalized epilepsyDnm1
impotenceCcnd1
infantile epileptic encephalopathyDnm1
infantile myofibromatosisNotch3
Infantile Myofibromatosis 2Notch3
infantile onset spinocerebellar ataxiaJag1
InfarctionNotch3
InflammationGata3
intellectual disabilityEp300 , Yy1
Intestinal NeoplasmsCdkn1a
Intestinal PolypsCcnd1
Intracranial HemorrhagesPsen1
invasive lobular carcinomaCcnd1
inverted papillomaCdkn1a
irritant dermatitisIl4
Jarcho-Levin syndromeDll3
Joubert syndrome 3Jag1
juvenile myelomonocytic leukemiaCbl
juvenile rheumatoid arthritisMaml2
Kawasaki diseaseIl4
Keratoconus 1Skp1
kidney diseaseCdkn1a
Kidney NeoplasmsCcnd1
Kidney Reperfusion InjuryEp300 , Myc
Language Development DisordersHdac2
Laryngeal NeoplasmsCdkn1a
Lateral Meningocele SyndromeNotch3
Lead Poisoning, Nervous SystemEp300
learning disabilityPsen1
Left Ventricular Noncompaction 7Mib1
leiomyomaMyc
leishmaniasisIl4
leukemiaCcnd1
Leukemia, ExperimentalCbl
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
liver cancerCrebbp
liver cirrhosisHdac2
Liver InjuryMyc
liver neoplasmCcnd1 , Cdkn1a , Myc , Ncor1
Liver Neoplasms, ExperimentalCcnd1 , Cdkn1a , Myc , Notch1
localized sclerodermaCdkn1a
lung adenocarcinomaCcnd1 , Crebbp , Eno1 , Ep300 , Fbxw7 , Myc
Lung NeoplasmsCcnd1 , Cdkn1a , Hes1 , Hey1 , Jag1 , Myc , Notch2 , Notch3
Lung Reperfusion InjuryIl4 , Myc
lung small cell carcinomaCcnd1 , Crebbp , Ep300
lung squamous cell carcinomaCcnd1 , Crebbp , Ep300 , Fbxw7
lymphangioleiomyomatosisHes1 , Jag2
Lymphatic MetastasisCdkn1a , Skp2
lymphomaNotch1
lymphopeniaCbl
macular degenerationCdkn1a
male infertilityCbl , Eno1
malignant gliomaCcnd1 , Dlk1 , Fbxw7 , Il4
malignant mesotheliomaCdkn1a , Il4
Mammary Neoplasms, AnimalCcnd1 , Cdkn1a , Eno1 , Furin , Gata3 , Notch4
Mammary Neoplasms, ExperimentalCcnd1 , Eno1 , Furin , Gata3 , Myc , Notch4
mantle cell lymphomaCcnd1
Marfan syndromeNotch1
maxillary sinus neoplasmCdkn1a
medulloblastomaCcnd1 , Crebbp , Ep300 , Fbxw7 , Myc , Skp2
melanomaCbl , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Hdac2 , Myc
membranoproliferative glomerulonephritisEp300
Memory DisordersHdac2 , Psen1
meningiomaHes1
Merkel cell carcinomaMyc
MetaplasiaGata3
microcephalyEp300
Microcephaly with Mental Retardation and Digital AnomaliesRbbp8
MicrognathismEp300
microphthalmiaNotch1
Microphthalmia, Syndromic 1Adam17 , Notch1 , Notch4
Microsatellite InstabilityHdac2
middle cerebral artery infarctionIl4
migraineNotch3
mitochondrial DNA depletion syndrome 7Jag1
Miyoshi Muscular Dystrophy 3Jag1
Monoclonal B-Cell LymphocytosisNotch2
Mouth NeoplasmsEno1
Multiple AbnormalitiesCrebbp , Ep300 , Hdac1 , Jag1
multiple myelomaCbl , Ccnd1 , Notch2
multiple sclerosisHdac1 , Il4 , Jag1 , Notch4 , Rbpj
Multisystem Autoimmune Disease, with Facial DysmorphismItch
Muscle HypotoniaEp300 , Hdac2
Muscle SpasticityCrebbp
Muscular Dystrophy-Dystroglycanopathy (congenital with brain and eye anomalies), Type A, 11Jag1
myelodysplastic syndromeCrebbp , Dlk1 , Myc
myelofibrosisNcor2
myeloid leukemiaHdac2
myeloid neoplasmCbl
myocardial infarctionDvl1
Myocardial IschemiaCcnd1
Myocardial Reperfusion InjuryCbl
Myoclonic EpilepsiesJag1
Myoclonic Epilepsy, Familial InfantileJag1
Myoclonus, Familial CorticalMyc
myopiaEp300
Nasopharyngeal NeoplasmsCcnd1
nasopharynx carcinomaCcnd1
Nematode InfectionsIl4
NeointimaYy1
Neonatal Inflammatory Skin and Bowel DiseaseAdam17
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neoplasm InvasivenessCtbp2 , Eno1 , Kdm1a
Neoplasm MetastasisCcnd1 , Cdkn1a , Myc
nephritisIl4
nephroblastomaMyc
nephronophthisis 3Gata3
nephronophthisis-like nephropathy 1Ep300
nephrosisGata3
nephrotic syndromeIl4
Nerve DegenerationPsen1
nervous system diseaseHes5 , Notch1
neural tube defectKat2a
Neuraminidase Deficiency with Beta-Galactosidase DeficiencyNeurl2
neuroblastomaMyc
neurodegenerative diseasePsen1
neuroectodermal tumorMyc
Neuropathy, PainfulEp300
non-Hodgkin lymphomaCcnd1 , Myc
non-small cell lung carcinomaCbl , Ccnd1 , Eno1 , Hes1 , Kat2a , Kdm1a , Myc , Notch3
nonalcoholic fatty liver diseaseIl4
Noonan Like SyndromeCbl
Noonan syndromeCbl
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaCbl
obesityEp300 , Myc
ocular hypertensionCdkn1a
oligodendrogliomaHes1 , Hey1
Optic Nerve InjuriesEp300 , Snw1
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a
osteoarthritisAdam12 , Eno1 , Jag1 , Ncor2
Osteoarthritis, HandIl4
Osteoarthritis, KneeIl4
osteochondrodysplasiaDll3
osteoporosisEno1 , Myc
osteosarcomaMyc
Otitis Media with EffusionIl4
ovarian cystMfap2
Ovarian NeoplasmsCcnd1 , Cdkn1a , Hdac1 , Hdac2 , Myc , Skp2
ovarian serous cystadenocarcinomaFbxw7
pancreatic adenocarcinomaCcnd1
pancreatic cancerCcnd1 , Il4 , Myc , Notch1 , Rbbp8 , Snw1
pancreatic carcinomaCdkn1a , Myc , Rbbp8
pancreatic ductal adenocarcinomaCcnd1
pancreatic ductal carcinomaCcnd1 , Cdkn1a , Dtx4 , Hdac1 , Hes1 , Hey1 , Hey2 , Il4 , Jag1 , Jag2 , Notch1 , Notch3 , Notch4
Pancreatic Intraepithelial NeoplasiaCcnd1 , Hdac1
pancreatic solid pseudopapillary carcinomaCcnd1
Pancreatitis, ChronicDll1 , Jag1
Pancreatitis, Experimental, Acute Cdkn1a , Il4
papillomaCcnd1 , Cdkn1a
Paroxysmal Atrial FibrillationMib1
pelvic inflammatory diseaseIl4
penile neoplasmCcnd1
Perennial Allergic RhinitisIl4
perinatal necrotizing enterocolitisEno1
Peritoneal DiseasesNotch1
Peyronie's diseaseHdac2
Phyllodes TumorCdkn1a
Pick's diseasePsen1
Pituitary NeoplasmsCdkn1a
pleomorphic xanthoastrocytomaDtx2
pleural diseaseIl4
pleuropulmonary blastomaYy1
Plummer-Vinson SyndromeRbbp8
pneumoconiosisIl4
pneumoniaIl4
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
polycystic ovary syndromeNcor1 , Ptcra
PolymyositisIl4
pre-eclampsiaNotch2
pre-malignant neoplasmCcnd1
precursor B lymphoblastic lymphoma/leukemiaCcnd1 , Gata3
precursor lymphoblastic lymphoma/leukemiaCcnd1 , Crebbp , Hdac1 , Hdac2 , Myc
precursor T-lymphoblastic lymphoma/leukemiaFbxw7 , Notch1
Premature AgingCdkn1a
Premature BirthIl4
primary biliary cirrhosisCdkn1a , Il4
primary open angle glaucomaCdkn1a
primary pulmonary hypertensionHdac1
Primitive Neuroectodermal TumorsHes1 , Hey1 , Notch2
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal RecessiveJag1
prolactinomaMyc
prostate cancerDll1 , Maml1 , Notch3
prostate carcinoma in situCcnd1 , Hdac1 , Myc
prostatic hypertrophyMyc
Prostatic NeoplasmsCcnd1 , Cdkn1a , Crebbp , Ctbp2 , Ep300 , Hdac1 , Hdac2 , Myc , Ncor1 , Ncor2 , Skp2 , Spen
psoriasisCdkn1a , Il4
pulmonary emphysemaHdac2
pulmonary fibrosisIl4 , Psen2
Pulmonary HemorrhagePsen2
pulmonary hypertensionCdkn1a , Hdac1 , Hdac2 , Il4 , Myc
pulmonary tuberculosisIl4
RASopathiesCbl
renal cell carcinomaCcnd1 , Myc , Skp2
renal fibrosisMyc
renal hypertensionCdkn1a
Reperfusion InjuryCcnd1 , Cdkn1a , Ep300
respiratory allergyIl4
Respiratory SoundsIl4
Respiratory Tract InfectionsIl4
reticulate acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryHdac2
RetrognathiaEp300
rhabdoid cancerMyc
rheumatoid arthritisEno1 , Gata3 , Notch4 , Rbpj
rhinitisIl4
RhinosinusitisIl4
Robinow syndromeDvl1 , Dvl3
Rubinstein-Taybi syndromeCrebbp , Ep300
Salivary Gland NeoplasmsCcnd1 , Cdkn1a , Jag1 , Mark2
sarcoidosisCdkn1a
sarcomaMaml3
SarcopeniaCdkn1a
schizophreniaKdm1a , Ncstn , Notch4
sciatic neuropathySnw1
scoliosisCrebbp , Dll3 , Notch1
Seasonal Allergic RhinitisIl4
sebaceous gland neoplasmCdkn1a
Seckel syndromeRbbp8
Seckel syndrome 2Rbbp8
sensorineural hearing lossGata3
Sensory Ataxic Neuropathy, Dysarthria, and OphthalmoparesisJag1
SepsisCdkn1a , Ep300
serous cystadenocarcinomaCdkn1a
Sezary's diseaseCrebbp
Shock, HemorrhagicIl4 , Myc
Sinonasal NeoplasmsCdkn1a
Sinonasal Undifferentiated CarcinomaMaml3
Sjogren's syndromeIl4
Skin NeoplasmsCdkn1a , Notch1 , Notch2 , Notch3 , Notch4
Smith-Magenis syndromeKat2a , Rfng
spina bifidaCrebbp
Spinal Cord InjuriesIl4
Spinocerebellar AtaxiasKat2a
SplenomegalyNotch1 , Psen1
spondylocostal dysostosisDll3 , Hes7 , Lfng
Spondylocostal Dysostosis 3, Autosomal RecessiveLfng
Spondylocostal Dysostosis 4, Autosomal RecessiveHes7
Spondylocostal Dysostosis 5Hes7
Spondylocostal Dysostosis, Autosomal RecessiveDll3 , Hes7 , Lfng
Sporadic Papillary Renal Cell CarcinomaFbxw7 , Myc
squamous cell carcinomaCcnd1 , Cdkn1a , Crebbp , Eno1 , Ep300 , Hdac1 , Hdac2 , Myc , Notch1 , Notch2 , Notch3 , Notch4
Staphylococcal InfectionsIl4
status epilepticusAdam10 , Ccnd1
Stevens-Johnson syndromeCul1 , Ep300
Stomach NeoplasmsCcnd1 , Cdkn1a , Eno1 , Hdac2 , Myc
StrokeHdac1 , Hdac2
syndactylyDll3 , Jag2
systemic lupus erythematosusCdkn1a , Ep300 , Il4
systemic sclerodermaIl4 , Notch4
T-cell leukemiaNotch1
T-Cell LymphomaCdkn1a , Ep300
tauopathyHdac1
temporal arteritisDll1 , Il4 , Jag1
temporal lobe epilepsyHdac2
tethered spinal cord syndromeCrebbp
tetralogy of FallotHey2 , Jag1 , Notch1
thoracic aortic aneurysmAdam10 , Adam17 , Notch1
Thumb DeformityCrebbp , Ep300
Thyroid NeoplasmsCcnd1 , Cdkn1a
Tongue NeoplasmsCdkn1a
tongue squamous cell carcinomaCdkn1a
transient cerebral ischemiaCbl , Ep300 , Kdm1a
transitional cell carcinomaCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Ncor1 , Skp2
Transplant RejectionMyc
trypanosomiasisIl4
Tuberculosis, BovineIl4
type 1 diabetes mellitusCbl , Hdac1 , Hdac2 , Il4 , Notch4 , Yy1
type 2 diabetes mellitusAdam17 , Ep300 , Hdac1 , Hdac2 , Notch2 , Rbpj , Rbpjl
type III Ehlers-Danlos syndromeNotch1
ulcerative colitisCdkn1a
Uniparental Disomy, Paternal, Chromosome 14Dlk1
urinary bladder cancerCcnd1 , Cdkn1a , Crebbp , Ep300 , Myc , Ncor1 , Ncstn
Urologic NeoplasmsCcnd1
uterine carcinosarcomaFbxw7
Uterine Cervical NeoplasmsCcnd1 , Cdkn1a , Crebbp , Ep300 , Fbxw7 , Hdac1 , Hdac2 , Hes1 , Myc , Notch1 , Notch2 , Skp2 , Yy1
Uterine NeoplasmsFbxw7
vasculitisCbl
ventricular septal defectNumb , Psen1
visual epilepsyCcnd1 , Hdac2 , Mib1 , Neurl1
vitiligoIl4
von Hippel-Lindau diseaseCcnd1
Weight GainRfng
Weight LossIl4
Wilson diseaseJag1
Wolf-Hirschhorn syndromeCtbp1
XerostomiaIl4
Pathway Annotations Associated with Genes in the Notch signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayCcnd1 , Myc
Alagille syndrome pathwayJag1
aldosterone signaling pathwayCrebbp , Ncor1 , Ncor2
allograft rejection pathwayIl4
altered androgen signaling pathwayNcor2
altered Notch signaling pathwayDll1 , Dll3 , Hey1 , Jag1 , Jag2 , Notch1 , Notch2 , Notch4 , Numb , Pofut1
altered Notch signaling pathway involving promotersHey1
altered Notch signaling pathway involving the macromolecules modifying the main playersNumb , Pofut1 , Psen2
altered Notch signaling pathway involving the main playersDll3 , Jag1 , Notch1 , Notch3
Alzheimer's disease pathwayAdam10 , Adam17 , Aph1a , Aph1b , Ncstn , Psen1 , Psen2 , Psenen
androgen signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
asthma pathwayIl4
ataxia telangiectasia-mutated (ATM) signaling pathwayRbbp8
autoimmune thyroiditis pathwayIl4
autophagy pathwayRab11a
basal cell carcinoma pathwayDvl1 , Dvl3
CADASIL pathwayNotch3
cell cycle pathway, mitoticCcnd1 , Cdkn1a , Crebbp , Cul1 , Ep300 , Hdac1 , Hdac1l , Hdac2 , Myc , Skp1 , Skp2
ceramide signaling pathwayCcnd1 , Myc
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2
chronic myeloid leukemia pathwayCbl , Ccnd1 , Cdkn1a , Ctbp1 , Ctbp2 , Hdac1 , Hdac1l , Hdac2 , Myc
clathrin-dependent synaptic vesicle endocytosisDnm1 , Eps15
colorectal cancer pathwayCcnd1 , Myc
cortisol signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
cytokine mediated signaling pathwayIl4
E-cadherin signaling pathwayCcnd1
eicosanoid signaling pathwayDnm1 , Rab11a
endocytosis pathwayCbl , Dnm1 , Eps15 , Itch , Rab11a
endometrial cancer pathwayCcnd1 , Myc
Endoplasmic Reticulum-associated degradation pathwayCul1 , Skp1
ephrin - ephrin receptor bidirectional signaling axisCbl , Dnm1
epidermal growth factor/neuregulin signaling pathwayAdam10 , Adam12 , Adam17 , Cbl , Cdkn1a , Myc
erythropoietin signaling pathwayCbl
estrogen signaling pathwayCrebbp , Ep300 , Ncor1 , Ncor2
Fanconi syndrome pathwayEno1
Fc epsilon receptor mediated signaling pathwayIl4
Fc gamma receptor mediated signaling pathwayDnm1
fibroblast growth factor signaling pathwayCbl
forkhead class A signaling pathwayCrebbp , Dlk1 , Ep300
fructose-1,6-bisphosphatase deficiency pathwayEno1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1 , Cdkn1a
glioma pathwayCcnd1 , Cdkn1a
gluconeogenesis pathwayEno1
glycogen storage disease type Ia pathwayEno1
glycogen storage disease type Ib pathwayEno1
glycogen storage disease type VII pathwayEno1
glycolysis pathwayEno1
glycolysis/gluconeogenesis pathwayEno1
glypican signaling pathwayFurin
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Sspo
hepatitis C pathwayCdkn1a
histone modification pathwayCrebbp , Ep300 , Hdac1 , Hdac2 , Kat2a , Kat2b , Kdm1a
homologous recombination pathway of double-strand break repairRbbp8
Huntington's disease pathwayCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2
hypoxia inducible factor pathwayCrebbp , Eno1 , Ep300 , Furin
influenza A pathwayCrebbp , Ep300 , Furin
INO80 family mediated chromatin remodeling pathwayYy1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCbl , Rab11a
insulin signaling pathwayCbl
interleukin-12 signaling pathwayIl4
interleukin-2 signaling pathwayMyc
interleukin-27 signaling pathwayGata3
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwayCbl , Il4
interleukin-6 signaling pathwayAdam10 , Adam17 , Myc
Jak-Stat signaling pathwayCbl , Ccnd1 , Crebbp , Ep300 , Il4 , Myc
Leishmaniasis pathwayIl4
long term potentiationCrebbp , Ep300
maturity-onset diabetes of the young pathwayHes1
measles pathwayCcnd1 , Il4
melanoma pathwayCcnd1 , Cdkn1a
mitogen activated protein kinase signaling pathwayMyc
mTOR signaling pathwaySspo , Yy1
myocarditis pathwayCcnd1
neddylation pathwayCul1
neurotrophic factor signaling pathwayPsen1 , Psen2
non-small cell lung carcinoma pathwayCcnd1
Notch signaling pathwayAdam10 , Adam12 , Adam17 , Aph1a , Aph1b , Cbl , Ccnd1 , Cdkn1a , Cir1 , Cntn1 , Cntn6 , Crebbp , Ctbp1 , Ctbp2 , Cul1 , Dlk1 , Dll1 , Dll3 , Dll4 , Dner , Dnm1 , Dtx2 , Dtx3 , Dtx3l , Dtx4 , Dvl1 , Dvl3 , Eno1 , Ep300 , Eps15 , Fbxw7 , Furin , Gata3 , Hdac1 , Hdac1l , Hdac2 , Hes1 , Hes5 , Hes7 , Hey1 , Hey2 , Heyl , Il4 , Itch , Jag1 , Jag2 , Kat2a , Kat2b , Kdm1a , Lfng , Lnx1 , Maml1 , Maml2 , Maml3 , Mark2 , Mfap2 , Mfap5 , Mfng , Mib1 , Myc , Mycbp , Ncor1 , Ncor2 , Ncstn , Neurl1 , Neurl2 , Notch1 , Notch2 , Notch3 , Notch4 , Numb , Numbl , Pofut1 , Psen1 , Psen2 , Psenen , Ptcra , Rab11a , Rbbp8 , Rbpj , Rbpjl , Rbpjl2 , Rfng , Skp1 , Skp2 , Snw1 , Spen , Sspo , Yy1
nuclear factor kappa B signaling pathwayCul1 , Skp1 , Sspo
nuclear factor, erythroid 2 like 2 signaling pathwayCdkn1a , Crebbp , Cul1 , Skp1
O-linked glycan biosynthetic pathwayLfng , Mfng , Pofut1 , Rfng
p38 MAPK signaling pathwayDlk1
p53 signaling pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Hdac1 , Kat2a , Kat2b , Skp2 , Yy1
pancreatic cancer pathwayCcnd1
phosphatidylinositol 3-kinase-Akt signaling pathwayCdkn1a
phosphoenolpyruvate carboxykinase deficiency pathwayEno1
platelet-derived growth factor signaling pathwayCbl , Myc
prion disease pathwayNotch1
prostate cancer pathwayCcnd1 , Cdkn1a , Crebbp , Ep300 , Ncor2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1
Rab family mediated signaling pathwayRab11a
Reelin signaling pathwayCbl
renal cell carcinoma pathwayCrebbp , Ep300
retinoic acid signaling pathwayNcor1 , Ncor2
Rho/Rac/Cdc42 mediated signaling pathwayCbl
RNA degradation pathwayEno1
RNA polymerase I transcription pathwayCrebbp
RNA polymerase II transcription initiation pathwayKat2a , Kat2b
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayCbl
small cell lung carcinoma pathwayCcnd1 , Myc , Skp2
spliceosome pathwaySnw1
syndecan signaling pathwayAdam12 , Aph1a , Aph1b , Ncstn , Psen1 , Psenen
T cell receptor signaling pathwayCbl , Il4
tamoxifen pharmacodynamics pathwayNcor1 , Ncor2
thyroid cancer pathwayCcnd1 , Myc
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Itch
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Cul1 , Ep300 , Myc , Skp1
triosephosphate isomerase deficiency pathwayEno1
tuberculosis pathwayCrebbp , Ep300
tumor necrosis factor mediated signaling pathwayAdam17 , Itch
type II interferon signaling pathwayCbl , Crebbp , Ep300
ubiquitin/proteasome degradation pathwayCbl , Cul1 , Itch , Skp1 , Skp2
urinary bladder cancer pathwayCcnd1 , Cdkn1a , Myc
vascular endothelial growth factor signaling pathwayCbl
vasopressin signaling pathwayRab11a
vasopressin signaling pathway via receptor type 2Rab11a
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayCcnd1 , Crebbp , Ctbp1 , Ctbp2 , Cul1 , Dvl1 , Dvl3 , Ep300 , Myc , Psen1 , Skp1
Wnt signaling, canonical pathwayCrebbp , Dvl1 , Dvl3
Wnt signaling, non-canonical pathwayDvl1 , Dvl3
Wnt signaling, the planar cell polarity pathwayDvl1
Phenotype Annotations Associated with Genes in the Notch signaling pathway

References Associated with the Notch signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: