WNT SIGNALING, CANONICAL PATHWAY (PW:0000201)

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Description

Wnt signaling pathways initiated by the Wnt family of secreted glycoproteins play important roles in the control of embryonic development, tissue regeneration, cell polarity, proliferation and cell fate determination. The canonical, beta-catenin-dependent pathway is the best understood system. In the Wnt-producing cells, Wnts are lipid modified by Porcn; the modification is important for Wnt secretion and signaling. Transport and secretion of Wnts requires the conserved transmembrane protein Wls

Pathway Diagram:

Elsevier Inc. Wls Csnk1g1 Wnt_ligands_secreted Sostdc1 Ndp Sost Crebbp translocated Ctnnb1 palmitate Wnt_ligands Rnf43 ---| Fzd_receptors Rnf43 ---| Fzd_receptors Znrf3 ---| Fzd_receptors Znrf3 ---| Fzd_receptors sFRPs ---| Wnt_ligands_secreted Wif1 ---| Wnt_ligands_secreted Znrf3 ---| Lrp6 Csnk1g1 --+> Lrp6 Gsk3b --+> Lrp6 Btrc ---| Ctnnb1 RSPOs ---> Wnt signal potentiation Ndp ---> Wnt signal potentiation Gsk3b Lrp6 Kremen2 Kremen1 Wif1 Porcn Lef1 Smarca4 Csnk1a1 Rnf43 Znrf3 Lgr4 Lgr5 RSPOs Btrc Axin1 Dvls Wnt signal potentiation Dkk members Axin1 ---- Lrp6 Dvls ---- Fzd_receptors Lrp5 sFRPs sFRPs ---- Wnt_ligands_secreted sFRPs ---> Fzd_receptors Fzd_receptors Fzd_receptors ---- sFRPs Apc Apc ---- Axin1 Axin1 ---- Gsk3b Apc ---- Ctnnb1 Lgr4 ---- Ndp RSPOs ---> Znrf3 Lrp6 ---- Sost Lrp5 ---- Sost Lrp6 ---- Sostdc1 Dkk members ---- Lrp5 Dkk members ---> Lrp5 Dkk members ---> Lrp6 Dkk members ---- Lrp6 Lrp5 ---- Ndp Lgr4 ---- RSPOs Lgr5 ---- RSPOs Fzd_receptors ---- Wnt_ligands_secreted Lrp5 ---- Wnt_ligands_secreted Wnt target genes Kremen2 ---> Dkk members Kremen1 ---> Dkk members Dkk members ---- Kremen1 Dkk members ---- Kremen2 Lrp6 ---- Wnt_ligands_secreted Axin1 ---- Ctnnb1 Csnk1a1 ---| Ctnnb1 Gsk3b ---| Ctnnb1 Ctnnb1 ---> translocated Ctnnb1 Wif1 ---- Wnt_ligands_secreted translocated Ctnnb1 ---> Wnt target genes Porcn ---> Wnt_ligands Wls ---- Wnt_ligands Wnt_ligands ---> Wnt_ligands_secreted Fzd_receptors ---- Ndp Axin2 Axin1 ---- Csnk1a1 Tcf_factors Csnk1a1 ---> Axin1 Ctnnb1 Gsk3b ---> Axin1
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Genes in Pathway:

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Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
RGD:6484113
G Axin1 axin 1 RGD:2293188
RGD:6484113
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:2293188
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2302032
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:2293188
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:2293188
RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:6484113
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:2293188
RGD:2301921
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 JBrowse link 2 237,148,918 237,240,883 RGD:2301921
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 JBrowse link 16 74,260,551 74,264,142 RGD:2301921
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1581696
RGD:6484113
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:6484113
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:6484113
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:7365107
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:2293491
G Fzd5 frizzled class receptor 5 JBrowse link 9 71,443,784 71,445,541 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Klhl12 kelch-like family member 12 JBrowse link 13 51,280,933 51,314,753 RGD:6484113
G Kremen1 kringle containing transmembrane protein 1 JBrowse link 14 85,441,209 85,503,661 RGD:2301921
G Kremen2 kringle containing transmembrane protein 2 JBrowse link 10 13,076,042 13,081,210 RGD:2301921
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:2293188
RGD:2301908
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:7365107
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:7365107
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
RGD:2293491
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:2293188
RGD:6484113
G Ndp NDP, norrin cystine knot growth factor JBrowse link X 6,791,090 6,815,586 RGD:7365107
G Nkd2 NKD2, WNT signaling pathway inhibitor JBrowse link 1 32,054,390 32,085,416 RGD:6484113
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha JBrowse link 1 261,337,594 261,362,509 RGD:6484113
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta JBrowse link 1 242,168,462 242,441,247 RGD:6484113
G Porcn porcupine O-acyltransferase JBrowse link X 15,035,569 15,048,440 RGD:7365109
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha JBrowse link 13 110,033,550 110,077,946 RGD:6484113
G Ranbp3 RAN binding protein 3 JBrowse link 9 10,344,190 10,381,415 RGD:6484113
G Rnf43 ring finger protein 43 JBrowse link 10 74,956,411 75,028,951 RGD:7365105
G Rspo1 R-spondin 1 JBrowse link 5 142,986,526 143,007,847 RGD:7365105
G Rspo2 R-spondin 2 JBrowse link 7 81,919,911 82,059,659 RGD:7365105
G Rspo3 R-spondin 3 JBrowse link 1 30,681,648 30,768,038 RGD:7365105
G Rspo4 R-spondin 4 JBrowse link 3 147,358,690 147,391,719 RGD:7365105
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:7365107
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:7365107
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 17 47,383,983 47,394,065 RGD:7365107
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:7365107
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:2302032
G Sost sclerostin JBrowse link 10 89,897,087 89,900,131 RGD:7365107
G Sostdc1 sclerostin domain containing 1 JBrowse link 6 55,812,820 55,816,994 RGD:7365107
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:2301908
G Tcf7l1 transcription factor 7 like 1 JBrowse link 4 100,492,796 100,660,401 RGD:2301908
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:2301908
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1304267
G Wif1 Wnt inhibitory factor 1 JBrowse link 7 63,094,955 63,165,158 RGD:2293188
G Wls Wnt ligand secretion mediator JBrowse link 2 266,315,036 266,431,220 RGD:7365109
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:2313743
RGD:13209023
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:2300202
RGD:2313743
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:2300029
RGD:2313743
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:2313743
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:2313743
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:2313743
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:2313743
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:2313743
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:2300202
RGD:6484113
RGD:2313743
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:2313743
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:2313743
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:2313743
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:2313743
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1601222
RGD:2313743
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1601222
RGD:2313743
RGD:2293491
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:2313743
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:2313743
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:2300156
RGD:2313743
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:2313743
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:7365105
altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:2293188
G Axin1 axin 1 RGD:2293188
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:4143515
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassDkk membersdickkopf homolog family of proteins
Functional ClassDvlsdisheveled, dsh homolog family of proteins
Functional ClassFzd_receptorsfrizzled homolog family of proteins
Functional ClassRSPOsRSPO family of agonists
Functional ClasssFRPssFRP family of antagonists
Functional ClassTcf_factorsTcf family of transcription factors
Functional ClassWnt_ligandswingless related family of proteins

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Wnt signaling, canonical pathway
Disease TermsGene Symbols
46 XX gonadal dysgenesisWnt4
46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and LungsWnt4
abdominal aortic aneurysmCav1
Aberrant Crypt FociApc , Ctnnb1 , Gsk3b
Abnormalities, Drug-InducedWnt11
acinar cell carcinomaApc
acoustic neuromaCav1
Acute HepatitisTsc2
acute kidney failureGsk3b , Wnt4
Acute Lung InjuryCav1
acute myeloid leukemiaCrebbp , Tsc2
acute myocardial infarctionGsk3b
adenocarcinomaApc , Ctnnb1 , Tcf7l2
adenoid cystic carcinomaCrebbp , Wnt5b
adenomaApc , Ctnnb1
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
adrenal carcinomaCtnnb1
Adrenal Gland NeoplasmsCtnnb1
adrenocortical carcinomaCtnnb1 , Znrf3
adult respiratory distress syndromeApc
adult T-cell leukemiaCsnk1a1
Aggressive FibromatosisApc
Al Awadi SyndromeWnt7a
Alcoholic Liver DiseasesCav1
Alzheimer's diseaseApc , Cav1 , Crebbp , Csnk1a1 , Ctnnb1 , Gsk3a , Gsk3b , Tsc2
amyotrophic lateral sclerosisGsk3a , Gsk3b
amyotrophic lateral sclerosis type 1Crebbp , Wnt7a
angiomyolipomaTsc2
angiosarcomaCtnnb1
Animal Disease ModelsLef1 , Wnt11
Animal Mammary NeoplasmsApc , Wnt1 , Wnt3 , Wnt6
ankyloglossiaLgr5
anodontiaAxin2 , Dkk1
anonychia congenitaRspo4
ascending colon cancerApc
atherosclerosisCav1
atrial fibrillationCav1 , Wnt3 , Wnt8a
atrial heart septal defectCrebbp
attention deficit hyperactivity disorderCrebbp
autism spectrum disorderTsc2
autistic disorderApc , Crebbp , Ctnnb1 , Tsc2 , Wnt2
autosomal dominant non-syndromic intellectual disability 19Ctnnb1
autosomal dominant osteopetrosis 1Lrp5
autosomal dominant pseudohypoaldosteronism type 1Cul3
autosomal dominant Robinow syndrome 1Dvl1 , Dvl3 , Wnt5a
autosomal dominant Robinow syndrome 2Dvl1 , Dvl3
autosomal dominant Robinow syndrome 3Dvl3
autosomal recessive limb-girdle muscular dystrophy type 2BApc
autosomal recessive limb-girdle muscular dystrophy type 2USostdc1
B-Cell Chronic Lymphocytic LeukemiaLef1
bipolar disorderGsk3a , Gsk3b
bladder exstrophyFzd5 , Wnt10a , Wnt11 , Wnt3 , Wnt6 , Wnt7a
bladder exstrophy-epispadias-cloacal exstrophy complexFzd5 , Wnt10a , Wnt11 , Wnt3 , Wnt6 , Wnt7a
bladder urothelial carcinomaCrebbp , Ctnnb1
Bone FracturesDkk1 , Lrp5
brain diseaseTsc2
Brain InjuriesGsk3b
brain ischemiaCav1
Brain NeoplasmsCtnnb1 , Tsc2
breast cancerApc , Cav1 , Smarca4 , Wnt1
Breast Cancer, FamilialApc
Breast NeoplasmsCav1 , Ctnnb1 , Dkk1 , Fzd1 , Lef1 , Rspo3 , Sfrp1 , Sfrp2 , Sfrp5 , Tsc2 , Wif1 , Wnt10b , Wnt2 , Wnt7b , Wnt9a
Burkitt lymphomaSmarca4
BurnsGsk3b
calcinosisCtnnb1
CarcinogenesisCav1
CardiomegalyCav1 , Gsk3b
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCtnnb1
Cell Transformation, NeoplasticApc , Wnt5a
central nervous system diseaseCrebbp
Charcot-Marie-Tooth disease dominant intermediate CRspo1
Chemical and Drug Induced Liver InjuryCtnnb1
cholangiocarcinomaApc , Rnf43
Coats diseaseNdp
Cocaine-Related DisordersSmarca4
Coffin-Siris syndromeSmarca4
Coffin-Siris syndrome 4Smarca4
cognitive disorderGsk3b
colon adenocarcinomaApc
colon cancerApc , Ctnnb1
colon carcinomaApc , Axin2 , Ctnnb1
Colonic NeoplasmsApc , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Lgr5 , Tcf7l2
colorectal adenocarcinomaGsk3b
colorectal adenomaApc
colorectal cancerApc , Axin2 , Ctnnb1 , Tcf7l2
Colorectal NeoplasmsApc , Axin1 , Axin2 , Crebbp , Ctnnb1 , Lgr5 , Rnf43 , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Tcf7l2 , Wif1
congenital diaphragmatic herniaWnt11
congenital generalized lipodystrophy type 3Cav1
congestive heart failureGsk3b
coronary artery diseaseLrp6
Coronary Artery Disease, Autosomal Dominant 2Lrp6
Coronary DiseaseTcf7l2
Craniodiaphyseal Dysplasia, Autosomal DominantSost
Craniofacial AbnormalitiesCsnk1a1 , Ctnnb1
craniometaphyseal dysplasiaSost
craniopharyngiomaApc , Ctnnb1
craniosynostosisAxin2
Crohn's diseaseTcf7
Currarino TriadDvl3
degenerative disc diseaseGsk3b
Dermal FibrosisCav1
Developmental DisabilitiesCrebbp , Smarca4
dextro-looped transposition of the great arteries 1Dvl2
diabetes mellitusCav1 , Tcf7l2
Diabetes Mellitus, Experimental Cav1 , Gsk3a , Smarca4 , Tsc2
Diabetic CardiomyopathiesCtnnb1
diabetic encephalopathyGsk3b
Diabetic NephropathiesDkk1 , Gsk3b , Tcf7l2
diabetic neuropathyCav1
DIARRHEA 9Wnt2b
DiGeorge syndromeDvl1
Digestive System NeoplasmsApc
dilated cardiomyopathyCtnnb1 , Gsk3a , Lef1
diseaseCtnnb1
disease of cellular proliferationApc , Ctnnb1
disease of mental healthDvl1
Disease ProgressionCtnnb1
Drug-Induced DyskinesiaGsk3b
duodenum adenocarcinomaApc
DwarfismWnt4
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPEKremen1
EctromeliaWnt3
EmphysemaPpp2r5a
endodermal sinus tumorCtnnb1 , Wnt2b
endometrial cancerApc
endometrial carcinomaApc , Gsk3b , Tsc2
Endometrial NeoplasmsApc , Axin2 , Ctnnb1 , Gsk3b , Rnf43 , Wnt2 , Wnt3 , Wnt4 , Wnt5a
Endometrioid CarcinomasApc , Ctnnb1 , Wif1
endometriosisDkk1
EpendymomaKremen2
epilepsyTsc2
esophageal carcinomaCtnnb1
Esophageal NeoplasmsWif1
esophagus squamous cell carcinomaCtnnb1
exfoliation syndromeCav1
Experimental ArthritisGsk3b , Sfrp4
Experimental Autoimmune MyocarditisCav1
Experimental Autoimmune NeuritisCav1
Experimental Liver CirrhosisCav1 , Lrp6 , Wls
Experimental Liver NeoplasmsCtnnb1
exudative vitreoretinopathyLrp5 , Ndp
Exudative Vitreoretinopathy 1Ctnnb1 , Lrp5
Exudative Vitreoretinopathy 4Lrp5
exudative vitreoretinopathy 7Ctnnb1
Eye AbnormalitiesApc
Failure to ThriveWnt2b
familial adenomatous polyposisApc
Familial Exudative Vitreoretinopathy, X-Linked RecessiveNdp
familial hypercholesterolemiaSmarca4
familial hyperlipidemiaApc
familial partial lipodystrophyCav1
Familial Prostate CancerRnf43 , Tcf7l2
fatty liver diseaseLrp6
Female InfertilityTsc2
Female Urogenital DiseasesWnt4 , Wnt5a , Wnt7a
Femoral FracturesDkk1 , Lef1
Femur Head NecrosisLrp5
FibroadenomaWnt2 , Wnt4
Fibromatosis, AbdominalApc
Focal Cortical Dysplasia of TaylorTsc2
focal dermal hypoplasiaPorcn
follicular lymphomaCrebbp
Fuhrmann syndromeWnt7a
fundus dystrophyLrp5
Gallbladder NeoplasmsApc
Gardner SyndromeApc
gastric adenocarcinomaCrebbp , Ctnnb1
Gastrointestinal HemorrhageApc
Gastrointestinal NeoplasmsApc
gastrointestinal stromal tumorApc
genetic diseaseAxin2 , Cav1 , Crebbp , Ctnnb1 , Cul3 , Dvl1 , Lrp5 , Porcn , Rspo4 , Smarca4 , Tsc2 , Wnt10a
Germ Cell and Embryonal NeoplasmsLrp6
gestational diabetesTcf7l2
glaucomaCrebbp , Lgr4
glioblastoma multiformeApc , Crebbp
granulosa cell tumorCtnnb1 , Wif1
HamartomaTsc2
head and neck squamous cell carcinomaCrebbp , Ctnnb1
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseGsk3b
heart valve diseaseLrp5
hemangiomaTsc2
HemorrhageCav1
hepatoblastomaApc , Ctnnb1
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
hepatocellular adenomaCtnnb1
hepatocellular carcinomaApc , Axin1 , Crebbp , Ctnnb1
Hereditary Desmoid DiseaseApc , Ctnnb1
Hereditary Eye DiseasesNdp
Hereditary Neoplastic SyndromesApc , Axin2 , Csnk1a1 , Smarca4 , Tcf7 , Tsc2 , Wnt8a
Hirschsprung Disease 1Crebbp , Tsc2
Hirschsprung's diseaseWnt8b
Huntington's diseaseCrebbp
HyperplasiaApc , Cav1 , Tcf7l2
hypertensionCav1 , Gsk3b
hypertrophic cardiomyopathyCav1 , Ctnnb1
hypothyroidismCav1 , Wnt3a
idiopathic generalized epilepsyDvl1
idiopathic juvenile osteoporosisLrp5
idiopathic pulmonary fibrosisWnt5a
imperforate anusCtnnb1
in situ carcinomaCtnnb1 , Sfrp1
inclusion body myositisCsnk1a1
InflammationTsc2
inflammatory bowel diseaseApc , Sfrp1 , Sfrp2
Insulin ResistanceTcf7l2
intellectual disabilityApc , Ctnnb1 , Tsc2
Intestinal NeoplasmsApc , Ctnnb1 , Gsk3b
Intestinal PolypsApc
intrahepatic cholangiocarcinomaApc
invasive lobular carcinomaCtnnb1
juvenile rheumatoid arthritisTcf7l2
Kabuki Syndrome 2Ndp
keratoconusLrp6 , Wnt1
kidney diseaseWnt4
Kidney NeoplasmsTsc2
Klatskin's tumorApc
Knee OsteoarthritisCtnnb1 , Dkk1
Leber congenital amaurosisLrp5
Left Ventricular HypertrophyGsk3a , Smarca4
leiomyomaCav1 , Sfrp1 , Tsc2 , Wnt5b , Wnt7a
LeukocytosisApc
limited sclerodermaCav1
Lipodystrophy with Congenital Cataracts and NeurodegenerationCav1
liver benign neoplasmApc , Ctnnb1
liver cancerApc , Axin1 , Crebbp , Ctnnb1
liver cirrhosisCtnnb1
Liver Reperfusion InjuryGsk3b
low tension glaucomaCav1
lung adenocarcinomaApc , Ctnnb1
Lung NeoplasmsApc , Cav1 , Ctnnb1 , Smarca4 , Wnt5a
lung small cell carcinomaCrebbp , Smarca4
lung squamous cell carcinomaCrebbp , Ctnnb1
lymphangioleiomyomatosisTsc2
Lymphatic MetastasisCav1 , Ctnnb1 , Tsc2
Lynch syndromeApc
macrocytic anemiaApc
malignant gliomaCav1
malignant mesotheliomaCtnnb1 , Wnt3
Mammary Neoplasms, ExperimentalCav1 , Ctnnb1 , Gsk3b , Wnt1 , Wnt2 , Wnt3 , Wnt3a , Wnt5b , Wnt6 , Wnt7a , Wnt7b
Mandibular NeoplasmsCtnnb1
mantle cell lymphomaCtnnb1 , Gsk3b , Wnt10a , Wnt3
medulloblastomaApc , Crebbp , Ctnnb1 , Smarca4 , Tsc2
melanomaApc , Cav1 , Crebbp , Ctnnb1 , Cul3
mental depressionGsk3a , Gsk3b
MesotheliomaApc
Metabolic Bone DiseasesDkk1 , Lrp5
Metabolic SyndromeLrp6
metaphyseal dysplasiaSfrp4
MetaplasiaAxin2
microphthalmiaLrp5
Microphthalmia, Syndromic 1Sfrp2 , Wnt7a
middle cerebral artery infarctionGsk3b
Miyoshi muscular dystrophyApc
Miyoshi muscular dystrophy 1Apc
Monoclonal B-Cell LymphocytosisApc
Mouth NeoplasmsTsc2
Mullerian AplasiaWnt4
Mullerian Aplasia and HyperandrogenismWnt4
Multiple AbnormalitiesCav1 , Crebbp , Ctnnb1 , Gsk3b , Lrp5 , Smarca4 , Wnt10a
multiple mitochondrial dysfunctions syndrome 3Rspo2
multiple sclerosisCav1
Muscle SpasticityCrebbp
muscular atrophyCtnnb1 , Gsk3b
Muscular Dystrophy-Dystroglycanopathy (congenital with brain and eye anomalies), Type A, 7Sostdc1
myelodysplastic syndromeCrebbp
myocardial infarctionDvl1 , Gsk3b , Sfrp2
Myocardial IschemiaSfrp4
Myocardial Reperfusion InjuryGsk3b , Sfrp2
myofibrillar myopathy 1Wnt10a , Wnt6
Myopathy, Distal, with Anterior Tibial OnsetApc
Nasopharyngeal NeoplasmsWif1
nemaline myopathy 6Csnk1g1
Neoplasm InvasivenessCtnnb1 , Lef1
Neoplasm MetastasisCav1 , Ctnnb1 , Lef1
Neoplasm Recurrence, LocalWnt10b
nephroblastomaCtnnb1 , Wif1
Nephrogenic Fibrosing DermopathyCav1
Nerve DegenerationCtnnb1 , Tsc2
neural tube defectLrp6
neuroblastomaSmarca4 , Tsc2
Neurodevelopmental DisordersCtnnb1 , Cul3 , Tcf7l2
neuronal ceroid lipofuscinosis 6Gsk3b
No-Reflow PhenomenonCtnnb1
non-small cell lung carcinomaApc
Norrie diseaseNdp
obesityCav1 , Smarca4 , Wnt10b , Wnt3a
Odontoonychodermal DysplasiaWnt10a
Oligodontia-Colorectal Cancer SyndromeAxin2
open-angle glaucomaCav1
Orofacial Cleft 1Lrp6
osteoarthritisCav1 , Frzb
osteochondrodysplasiaSost
osteogenesis imperfectaLrp5
osteogenesis imperfecta type 15Wnt1 , Wnt10b
osteopetrosisLrp5
osteoporosisLgr4 , Lrp5 , Wnt1
osteoporosis-pseudoglioma syndromeLrp5
osteosarcomaTsc2
ovarian cancerApc , Ctnnb1
ovarian cystSfrp4
Ovarian NeoplasmsCav1 , Ctnnb1 , Gsk3b , Lef1 , Smarca4 , Wnt7a
Oxygen-Induced RetinopathyNdp
Palmoplantar Hyperkeratosis and True HermaphroditismRspo1
Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and Sex ReversalRspo1
palmoplantar keratosisWnt10a
pancreatic adenocarcinomaCtnnb1
pancreatic cancerApc , Ctnnb1 , Smarca4 , Tcf7l2 , Tsc2 , Wnt9a , Znrf3
pancreatic ductal carcinomaTsc2
papillary renal cell carcinomaCtnnb1 , Wnt2
papillary thyroid carcinomaCtnnb1 , Lef1
Parasitic Liver DiseasesRnf43
Parathyroid NeoplasmsCtnnb1
Parkinson's diseaseGsk3b
Parkinsonian DisordersGsk3a
pathologic nystagmusNdp
periampullary adenomaApc
Peritoneal NeoplasmsCtnnb1
peritonitisGsk3b
Phyllodes TumorCtnnb1
pilomatrixomaCtnnb1
pleomorphic xanthoastrocytomaCav1 , Fzd1 , Sfrp4 , Sostdc1 , Wnt16 , Wnt2
PoisoningGsk3b
polycystic kidney disease 1Lrp5
polycystic liver diseaseLrp5
Polycystic Liver Disease 1Lrp5
Polycystic Liver Disease 4 with or without Kidney CystsLrp5
Polyposis, GastricApc
Postmenopausal OsteoporosisLrp5
Potter Type III Polycystic Kidney DiseaseLrp5
pre-malignant neoplasmTsc2
precursor lymphoblastic lymphoma/leukemiaCrebbp
precursor T-lymphoblastic lymphoma/leukemiaSmarca4
primary open angle glaucomaCav1
primary pulmonary hypertensionCav1
Primary Pulmonary Hypertension, 3Cav1
Progressive Osseous HeteroplasiaCtnnb1
proliferative vitreoretinopathyLrp5
prostate adenocarcinomaCtnnb1
prostate cancerApc , Ctnnb1 , Lef1 , Lrp6 , Tcf7 , Tcf7l2
prostate carcinoma in situLef1
Prostatic NeoplasmsApc , Cav1 , Crebbp , Ctnnb1 , Cul3 , Gsk3b , Rnf43 , Smarca4 , Wif1 , Wnt10b , Wnt11 , Wnt2 , Wnt4
pseudohypoaldosteronismCul3
Pseudohypoaldosteronism, Type IIECul3
psoriasisCav1
pulmonary fibrosisCav1
pulmonary hypertensionCav1
rectal neoplasmApc
rectum adenocarcinomaApc
renal cell carcinomaApc , Cav1 , Ctnnb1 , Sfrp1 , Sfrp2 , Tsc2 , Wif1 , Wnt11
Reperfusion InjuryCav1 , Wnt3a
retinal detachmentNdp
retinopathy of prematurityNdp
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
Robinow syndromeDvl1 , Dvl3 , Wnt5a
Rubinstein-Taybi syndromeCrebbp
Salivary Gland NeoplasmsWnt5b
sarcomaSmarca4
SarcopeniaCav1
schizophreniaGsk3a , Gsk3b , Lgr4
Schopf-Schulz-Passarge SyndromeWnt10a
sciatic neuropathyCav1 , Gsk3b
sclerosteosisSost
sclerosteosis 1Sost
scoliosisCrebbp
sebaceous gland neoplasmLef1
Selective Tooth Agenesis 4Wnt10a
Selective Tooth Agenesis 7Lrp6
Selective Tooth Agenesis 8Wnt10b
SepsisGsk3b
Serrated PolyposisApc , Rnf43
SESSILE SERRATED POLYPOSIS CANCER SYNDROMERnf43
Sezary's diseaseCrebbp , Smarca4
sigmoid colon cancerApc
skin melanomaCtnnb1
Skin NeoplasmsCtnnb1
small cell carcinomaSmarca4 , Wif1
Smith-Magenis syndromeAxin2 , Rnf43 , Sost , Wnt3 , Wnt9b
SOST-related sclerosing bone dysplasiaLrp5 , Sost
spina bifidaCrebbp
Spinal Cord InjuriesCav1 , Lrp5
Spine OsteoarthritisLrp5
SplenomegalyApc
split hand-foot malformationBtrc
split hand-foot malformation 6Wnt10b
squamous cell carcinomaCav1 , Crebbp , Tsc2
status epilepticusGsk3b
Stevens-Johnson syndromeCav1 , Ctnnb1
stomach cancerApc
Stomach NeoplasmsApc , Cav1 , Ctnnb1 , Rnf43 , Wif1
StrokeCtnnb1 , Wnt2b
Subarachnoid HemorrhageGsk3b
substance-related disorderGsk3b
systemic lupus erythematosusTcf7
systemic sclerodermaCav1
TachycardiaGsk3b
tauopathyGsk3b
tendinitisLrp5
teratomaCtnnb1 , Wnt2b
Tetra-Amelia Autosomal RecessiveWnt3
Thoracic NeoplasmsSmarca4
Thumb DeformityCrebbp
Thyroid NeoplasmsTcf7l1
tooth agenesisAxin2 , Lrp6 , Wnt10a
transient cerebral ischemiaCav1
transitional cell carcinomaApc , Cav1 , Crebbp , Ctnnb1
Triple Negative Breast NeoplasmsLrp6
tuberous sclerosisTsc2
tuberous sclerosis 1Tsc2
tuberous sclerosis 2Tsc2
Tumor Predisposition SyndromeApc , Tsc2
Turcot SyndromeApc
type 2 diabetes mellitusGsk3b , Sfrp4 , Tcf7l2
urinary bladder cancerCav1 , Crebbp , Ctnnb1 , Wif1 , Wnt7b
Urogenital AbnormalitiesWnt4
Urogenital NeoplasmsWnt7a
Urologic NeoplasmsWnt2
Uterine Cervical NeoplasmsCrebbp , Ctnnb1 , Wnt2 , Wnt5a
uterine fibroidTsc2
Uterine NeoplasmsCtnnb1
Vascular CalcificationCtnnb1
vascular dementiaGsk3b
ventricular septal defectSmarca4
visual epilepsyDkk1 , Tsc2 , Wnt2
Weight GainCav1
Weissenbacher-Zweymuller syndromeDvl2
West syndromeTsc2
Worth SyndromeLrp5
Worth's syndromeLrp5
Pathway Annotations Associated with Genes in the Wnt signaling, canonical pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayLef1 , Tcf7 , Tcf7l2
aldosterone signaling pathwayCrebbp
altered SWI/SNF family mediated chromatin remodeling pathwaySmarca4
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Lrp5 , Tcf7l2 , Wnt9a
Alzheimer's disease pathwayGsk3b
androgen signaling pathwayCrebbp
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayGsk3b
basal cell carcinoma pathwayApc , Axin1 , Axin2 , Ctnnb1 , Dvl1 , Dvl3 , Fzd1 , Fzd5 , Gsk3b , Lef1 , Tcf7 , Tcf7l2 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Bone morphogenetic proteins signaling pathwayGsk3b , Sostdc1
cell cycle pathway, mitoticCrebbp , Gsk3b
chemokine mediated signaling pathwayGsk3a , Gsk3b
colorectal cancer pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
cortisol signaling pathwayCrebbp , Smarca4
dopamine signaling pathwayCsnk1a1
E-cadherin signaling pathwayCtnnb1
endocytosis pathwayCav1 , Pip5k1b
endometrial cancer pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
epidermal growth factor/neuregulin signaling pathwayGsk3b
estrogen signaling pathwayCrebbp
Fc gamma receptor mediated signaling pathwayPip5k1b
forkhead class A signaling pathwayCrebbp
glycogen biosynthetic pathwayGsk3a , Gsk3b
Hedgehog signaling pathwayBtrc , Crebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
hepatitis C pathwayGsk3b
histone modification pathwayCrebbp , Smarca4
Huntington's disease pathwayCrebbp
hypoxia inducible factor pathwayCrebbp
influenza A pathwayCrebbp , Gsk3b
inositol phosphate metabolic pathwayPi4k2a , Pip5k1b
insulin responsive facilitative sugar transporter mediated glucose transport pathwayGsk3b
insulin signaling pathwayCav1 , Gsk3b , Tsc2
Jak-Stat signaling pathwayCrebbp
long term depressionGsk3b
long term potentiationCrebbp
measles pathwayGsk3b
mitogen activated protein kinase signaling pathwayTsc2
mRNA decay pathwayPpp2r5a
mTOR signaling pathwayTsc2
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Lrp5
neddylation pathwayCul3
neurotrophic factor signaling pathwayGsk3b
Notch signaling pathwayCrebbp , Dvl1 , Dvl3
nuclear factor kappa B signaling pathwayBtrc
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Crebbp , Cul3 , Gsk3a , Gsk3b
p53 signaling pathwayCrebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Tsc2
pancreatic cancer pathwaySmarca4 , Tcf7l2 , Wnt9a
phosphatidylinositol 3-kinase signaling pathwayPi4k2a , Pip5k1b
phosphatidylinositol 3-kinase-Akt signaling pathwayGsk3a , Gsk3b
platelet-derived growth factor signaling pathwayCav1
prostate cancer pathwayCrebbp , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul3
Reelin signaling pathwayGsk3b
renal cell carcinoma pathwayCrebbp
reverse cholesterol transport pathwayCav1
RNA polymerase I transcription pathwayCrebbp
SWI/SNF family mediated chromatin remodeling pathwaySmarca4
T cell receptor signaling pathwayGsk3b
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayTsc2
the Wnt/calcium signaling pathwayWnt11
thyroid cancer pathwayCtnnb1 , Lef1 , Tcf7 , Tcf7l2
transforming growth factor-beta signaling pathwayTsc2
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp
tuberculosis pathwayCrebbp
tumor necrosis factor mediated signaling pathwayCav1
type II interferon signaling pathwayCrebbp
ubiquitin/proteasome degradation pathwayBtrc , Cul3
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1
Wnt signaling pathwayApc , Axin1 , Axin2 , Btrc , Crebbp , Csnk1a1 , Ctnnb1 , Dkk1 , Dkk2 , Dkk4 , Dvl1 , Dvl2 , Dvl3 , Fzd1 , Fzd5 , Gsk3b , Lef1 , Lrp5 , Lrp6 , Nkd2 , Porcn , Ppp2r5a , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Tcf7 , Tcf7l2 , Wif1 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Btrc , Cav1 , Crebbp , Csnk1a1 , Csnk1g1 , Ctnnb1 , Cul3 , Dkk1 , Dkk2 , Dkk4 , Dvl1 , Dvl2 , Dvl3 , Frzb , Fzd1 , Fzd5 , Gsk3a , Gsk3b , Klhl12 , Kremen1 , Kremen2 , Lef1 , Lgr4 , Lgr5 , Lrp5 , Lrp6 , Ndp , Nkd2 , Pi4k2a , Pip5k1b , Porcn , Ppp2r5a , Ranbp3 , Rnf43 , Rspo1 , Rspo2 , Rspo3 , Rspo4 , Sfrp1 , Sfrp2 , Sfrp4 , Sfrp5 , Smarca4 , Sost , Sostdc1 , Tcf7 , Tcf7l1 , Tcf7l2 , Tsc2 , Wif1 , Wls , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b , Znrf3
Wnt signaling, non-canonical pathwayCsnk1a1 , Dvl1 , Dvl2 , Dvl3 , Fzd5 , Wnt5a , Wnt7a
Wnt signaling, the planar cell polarity pathwayDvl1 , Dvl2 , Wnt7b
Phenotype Annotations Associated with Genes in the Wnt signaling, canonical pathway

References Associated with the Wnt signaling, canonical pathway:

Ontology Path Diagram:

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