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The planar cell polarity Wnt signaling pathway (PCP) plays a major role in embryonic tissue patterning, cell polarization, migration and morphogenesis. The PCP pathway, along with the Wnt-calcium pathway, belongs to the non-canonical Wnt signaling in that is independent of beta-catenin, the core component of the canonical Wnt pathway. The PCP pathway is less well understood and characterized but evidence is rapidly accumulating establishing the core components and the role they play, the common

Pathway Diagram:

Elsevier Inc. Prickle1 ---| Dvls Scrib Vangl2 Rac1 Daam1 Rhoa Celsr1 Dvls Prickle1 ---- Vangl2 Prickle2 Prickle1 Ptk7 Dvls ---- Prickle1 Daam1 ---- Dvls Dvls ---- Rac1 Dvls ---- Fzd_receptors Fzd_receptors ---- Wnt_ligands Celsr1 --+> Vangl2 Daam1 ---- Rhoa Scrib ---- Vangl2 Scrib --+> Vangl2 Rac1 ---> Rho/Rac/Cdc42 mediated signaling pathway Rhoa ---> Rho/Rac/Cdc42 mediated signaling pathway Rac1 ---> c-Jun N-terminal kinases MAPK signaling pathway Wnt_ligands Fzd_receptors Ptk7 ---- Vangl2 Prickle2 ---- Vangl2 Rho/Rac/Cdc42 mediated signaling pathway c-Jun N-terminal kinases MAPK signaling pathway

Genes in Pathway:

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Wnt signaling, the planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:2293492
G Daam1 dishevelled associated activator of morphogenesis 1 JBrowse link 6 94,606,675 94,739,026 RGD:2293492
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1581694
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:2293492
G Fzd3 frizzled class receptor 3 JBrowse link 15 48,601,259 48,670,257 RGD:2293492
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:2293492
G Prickle1 prickle planar cell polarity protein 1 JBrowse link 7 134,702,964 134,799,437 RGD:2293492
G Prickle2 prickle planar cell polarity protein 2 JBrowse link 4 124,238,167 124,584,176 RGD:2293492
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:2293492
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1581694
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:2302030
G Scrib scribbled planar cell polarity protein JBrowse link 7 117,105,810 117,128,802 RGD:2293492
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:2293492
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1581694

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassDvldishevelled, dsh homolog family of proteins
Functional ClassWntwingless related family of proteins

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Wnt signaling, the planar cell polarity pathway
Disease TermsGene Symbols
Abnormalities, Drug-InducedRhoa
Animal Disease ModelsRhoa
autosomal dominant mental retardation 48Rac1
autosomal dominant Robinow syndrome 1Dvl1
autosomal dominant Robinow syndrome 2Dvl1
autosomal recessive Robinow syndromePrickle1
benign epilepsy with centrotemporal spikesPrickle1 , Prickle2
Brain InjuriesRhoa
breast cancerRhoa , Wnt7b
breast carcinomaRhoa
breast fibroadenomaWnt7b
Breast NeoplasmsRhoa
CardiomegalyRac1 , Rhoa
Cell Transformation, NeoplasticRac1
colon adenocarcinomaRac1
colon adenomaRac1
colorectal cancerRac1 , Rhoa
Colorectal NeoplasmsRhoa
congenital diaphragmatic herniaRhoa
congestive heart failureRac1
cutaneous T cell lymphomaRhoa
dextro-looped transposition of the great arteries 1Dvl2
diabetes mellitusRac1
Diabetes Mellitus, Experimental Rhoa
DiGeorge syndromeDvl1
dilated cardiomyopathyRac1
disease of mental healthDvl1
esophageal carcinomaRhoa
Experimental Autoimmune EncephalomyelitisRhoa
Experimental Autoimmune NeuritisRhoa
Experimental Liver CirrhosisRhoa
gastric adenocarcinomaRhoa
genetic diseaseDvl1 , Rhoa
Germ Cell and Embryonal NeoplasmsRhoa
head and neck squamous cell carcinomaRac1 , Rhoa
hepatocellular carcinomaRac1
Hydrops FetalisFzd6
idiopathic generalized epilepsyDvl1
Immunoblastic LymphadenopathyRhoa
intrinsic cardiomyopathyDaam1
Kidney NeoplasmsVangl2
Left Ventricular HypertrophyRac1 , Rhoa
liver benign neoplasmPrickle2
liver diseaseRac1
long QT syndromeCelsr1
lung adenocarcinomaRhoa
Lymphatic MetastasisRhoa
Malformations of Cortical Development, Group IICelsr1
Mammary Neoplasms, ExperimentalWnt7b
Matthew-Wood syndromeWnt7b
melanomaPrickle1 , Rac1
membranous glomerulonephritisRhoa
Microphthalmia, Syndromic 5Wnt7b
multiple sclerosisRhoa
myocardial infarctionDvl1
Myocardial Reperfusion InjuryRhoa
nail diseaseFzd6
Neoplasm InvasivenessRhoa
Neoplasm MetastasisRac1 , Rhoa
neural tube defectVangl2
Neurodevelopmental DisordersPtk7
non-Hodgkin lymphomaRhoa
nonsyndromic congenital nail disorder 10Fzd6
Optic Nerve InjuriesRhoa
ovarian carcinomaRhoa
pancreatic adenocarcinomaRac1
pancreatic ductal adenocarcinomaRac1
peripheral T-cell lymphomaRhoa
pre-malignant neoplasmPrickle2
Prickle1-Related Progressive Myoclonic Epilepsy with AtaxiaPrickle1
progressive myoclonus epilepsyPrickle1 , Prickle2
pulmonary hypertensionRhoa
Robinow syndromeDvl1
Sensory Ataxic Neuropathy, Dysarthria, and OphthalmoparesisPrickle2
skin melanomaRac1
spina bifidaVangl2
Stomach NeoplasmsRhoa
T-Cell LymphomaRhoa
temporal lobe epilepsyPrickle1
urinary bladder cancerRhoa , Wnt7b
Urologic NeoplasmsRhoa
Uterine NeoplasmsRac1
velocardiofacial syndromePrickle1
Ventricular Dysfunction, LeftRac1
visual epilepsyPrickle1
Weissenbacher-Zweymuller syndromeDvl2
Williams-Beuren syndromeFzd3
Pathway Annotations Associated with Genes in the Wnt signaling, the planar cell polarity pathway
Pathway TermsGene Symbols
amyotrophic lateral sclerosis pathwayRac1
Arf family mediated signaling pathwayRac1
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayRac1
basal cell carcinoma pathwayDvl1 , Fzd3 , Fzd6 , Wnt7b
c-Jun N-terminal kinases MAPK signaling pathwayRac1
calcium signaling pathway via the calcium-sensing receptorRhoa
ceramide signaling pathwayRac1
chemokine mediated signaling pathwayRac1 , Rhoa
colorectal cancer pathwayRac1 , Rhoa
E-cadherin signaling pathwayRac1 , Rhoa
eicosanoid signaling pathwayRac1 , Rhoa
endocytosis pathwayRhoa
endothelin signaling pathwayRac1 , Rhoa
ephrin - ephrin receptor bidirectional signaling axisRac1 , Rhoa
Fc epsilon receptor mediated signaling pathwayRac1
Fc gamma receptor mediated signaling pathwayRac1
Hedgehog signaling pathwayWnt7b
insulin responsive facilitative sugar transporter mediated glucose transport pathwayRac1
interleukin-2 signaling pathwayRhoa
interleukin-6 signaling pathwayRac1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayRac1
mTOR signaling pathwayRac1 , Rhoa
myocarditis pathwayRac1
N-cadherin signaling pathwayRac1 , Rhoa
neurotrophic factor signaling pathwayRac1 , Rhoa
Notch signaling pathwayDvl1
p38 MAPK signaling pathwayRac1
pancreatic cancer pathwayRac1
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayRac1 , Rhoa
platelet-derived growth factor signaling pathwayRac1 , Rhoa
renal cell carcinoma pathwayRac1
Rho/Rac/Cdc42 mediated signaling pathwayRac1 , Rhoa
sphingosine 1-phosphate signaling pathwayRac1 , Rhoa
syndecan signaling pathwayRac1 , Rhoa
T cell receptor signaling pathwayRhoa
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayRac1
transforming growth factor-beta Smad dependent signaling pathwayRhoa
transforming growth factor-beta superfamily mediated signaling pathwayRhoa
tuberculosis pathwayRhoa
vascular endothelial growth factor signaling pathwayRac1 , Rhoa
Wnt signaling pathwayDaam1 , Dvl1 , Dvl2 , Fzd3 , Fzd6 , Prickle1 , Prickle2 , Rac1 , Rhoa , Vangl2 , Wnt7b
Wnt signaling, canonical pathwayDvl1 , Dvl2 , Wnt7b
Wnt signaling, non-canonical pathwayDaam1 , Dvl1 , Dvl2 , Fzd6 , Rac1 , Rhoa
Wnt signaling, the planar cell polarity pathwayCelsr1 , Daam1 , Dvl1 , Dvl2 , Fzd3 , Fzd6 , Prickle1 , Prickle2 , Ptk7 , Rac1 , Rhoa , Scrib , Vangl2 , Wnt7b

References Associated with the Wnt signaling, the planar cell polarity pathway:

Ontology Path Diagram:

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