P38 MAPK SIGNALING PATHWAY (PW:0000198)

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Description

The p38 MAPK pathway, also known as a stress activated protein kinase pathway (SAPK) responds to various cellular stresses and to inflammatory cytokines. P38 displays the characteristic three-tier core cascade MAPK architecture. The downstream and effector MAPK tier of p38 pathway are represented by Mapk14, Mapk11, Mapk12 and Mapk13 known as p38 alpha, beta, gamma and delta, respectively. They are activated by phosphorylation of threonine and tyrosine residues within the conserved TGY motif in

Pathway Diagram:

Elsevier Inc. upstream p38 adapters ---- upstream p38 adapters other p38 Map3k p38 cytoplasmic/other targets hyperosmolarity Map2k6 --+> Mapk13 Map2k6 --+> Mapk12 Map2k3 --+> Mapk13 Map2k6 --+> Mapk11 Map2k6 --+> Mapk14 Map2k3 --+> Mapk11 other p38 Map3k --+> Map2k6 Map3k3 --+> Map2k6 Ppm1d ---| Mapk14 p38 Dusp members ---| Mapk14 p38 Dusp members ---| Mapk11 Traf2 --+> Map3k7 Traf6 --+> Map3k7 Mapk13 Mapk12 Mapk11 Mapk14 Ppm1d p38 Dusp members Map2k6 Map2k3 Cdc42 Bnip2 Spag9 Cdon Traf6 Traf2 Ccm2 Map3k7 Map3k3 Map3k5 --+> Map2k3 adapters ---- Traf6 adapters ---- Traf2 Rac1 --+> Map3k3 actin polymerization --+> Rac1 Map3k7 --+> Map2k6 hyperosmolarity ---> actin polymerization Map3k5 --+> Map2k6 Map3k3 --+> Map2k3 Map3k7 --+> Map2k3 Ccm2 ---- Map2k3 Ccm2 ---- Map3k3 Ccm2 ---- Rac1 p38 activated MAPKAPK Mapk14 --+> p38 activated MAPKAPK Mapk11 --+> p38 activated MAPKAPK Mapk12 ---> p38 nuclear targets p38 nuclear targets Mapk14 ---> p38 cytoplasmic/other targets Mapk12 ---> p38 cytoplasmic/other targets Mapk11 ---> p38 cytoplasmic/other targets Mapk11 ---> p38 nuclear targets Mapk14 ---> p38 nuclear targets Mapk13 ---> p38 cytoplasmic/other targets other p38 Map3k ---> Map2k3 stress conditions stress conditions --+> Map3k5 Map3k5 ---- Spag9 Cdon ---- Map3k7 Cdon ---- Map3k5 Cdon ---- Spag9 Bnip2 ---- Cdon actin polymerization Rac1 Map3k5 Map3k7 ---- Spag9 Bnip2 ---- Cdc42 Map2k3 --+> Mapk14 Map2k3 ---> Mapk12
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Genes in Pathway:

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p38 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1625329
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6484113
G Bnip2 BCL2 interacting protein 2 JBrowse link 8 76,400,333 76,426,307 RGD:7240533
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6484113
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6484113
G Ccm2 CCM2 scaffold protein JBrowse link 14 86,812,728 86,859,408 RGD:2293891
RGD:7240533
RGD:6484113
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:7240533
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:7240533
G Dlk1 delta like non-canonical Notch ligand 1 JBrowse link 6 133,576,513 133,583,751 RGD:7240533
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7240533
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:7240533
G Dusp16 dual specificity phosphatase 16 JBrowse link 4 168,470,141 168,551,346 RGD:7240533
G Dusp9 dual specificity phosphatase 9 JBrowse link X 157,168,143 157,172,068 RGD:7240533
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6484113
G Gadd45b growth arrest and DNA-damage-inducible, beta JBrowse link 7 11,646,283 11,648,338 RGD:6484113
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:2293891
RGD:6484113
RGD:2298758
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:2293891
RGD:6484113
RGD:2298758
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:6484113
G Map3k10 mitogen activated protein kinase kinase kinase 10 JBrowse link 1 84,473,178 84,491,689 RGD:6484113
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 1 221,043,119 221,056,420 RGD:7240533
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:7240533
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:2293891
RGD:7240533
RGD:6484113
G Map3k4 mitogen activated protein kinase kinase kinase 4 JBrowse link 1 48,625,714 48,711,642 RGD:6484113
RGD:7240533
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:6484113
RGD:7240533
G Map3k6 mitogen-activated protein kinase kinase kinase 6 JBrowse link 5 151,435,679 151,448,329 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:2293891
RGD:7240533
RGD:6484113
RGD:2298758
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:7240533
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:2293891
RGD:6484113
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:2293891
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:2293891
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1580544
RGD:6484113
RGD:2293891
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 JBrowse link 7 130,430,588 130,440,838 RGD:2293891
RGD:2302280
G Mapkapk2 mitogen-activated protein kinase-activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:2315047
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 8 116,012,126 116,046,012 RGD:2315047
G Mapkapk5 mitogen-activated protein kinase-activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:2315047
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:2315047
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 JBrowse link 7 11,908,107 11,919,161 RGD:2315047
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:7240533
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:2293891
RGD:6484113
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:2315047
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:2315047
G Spag9 sperm associated antigen 9 JBrowse link 10 81,693,736 81,827,562 RGD:7240533
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6484113
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:6484113
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:6484113
RGD:7240533
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:6484113
RGD:7240533
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:6484113
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:2296020
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:6484113
RGD:7240533
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classother kinases of the upstream tier
Functional Classphosphatases of the Dusp family
Gene Groupp38 cytoplasmic/other targets
Gene Groupp38 nuclear targets
Functional Classp38 activated MAPKAPKadditional kinase tier that furthers the signal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the p38 MAPK signaling pathway
Disease TermsGene Symbols
46 XY gonadal dysgenesisMap3k1
46,XY Sex Reversal 6Map3k1
abdominal aortic aneurysmAdm
AcidosesAdm
Acute Liver FailureAtm
Acute Lung InjuryTxn1
adenoid cystic carcinomaAtm
Adrenal Gland NeoplasmsCdc42
AlbuminuriaAdm
allergic conjunctivitisIrf1
allergic hypersensitivity diseaseMap2k6
Alzheimer's diseaseAtm , Calm1 , Cdc42 , Mapk14
Amyloid NeuropathiesDusp1
amyotrophic lateral sclerosisMap3k5 , Mapk14
anti-basement membrane glomerulonephritisDusp1 , Mapk14
Arsenic PoisoningGadd45b
Arterial InjuryMap3k5
Arterial Occlusive DiseasesTxn1
arteriosclerosisAtm , Dusp1
asthmaIrf1
astrocytomaMap2k3
ataxia telangiectasiaAtm
Ataxia-Telangiectasia VariantAtm
autism spectrum disorderMapk11 , Mapk12 , Mapk8ip2 , Taok2
autistic disorderAdm
autosomal dominant mental retardation 48Rac1
autosomal dominant mental retardation 54Camk2b
B-cell lymphomaAtm
BacteremiaMapkapk3
bacterial pneumoniaIrf1
bilateral breast cancerAtm
biliary atresiaDlk1
bipolar disorderCdc42
Brain DeathMap2k6
brain infarctionAdm
Brain InjuriesIrf1
Brain Stem NeoplasmsPpm1d
breast cancerAtm , Ppm1d
Breast Cancer, FamilialAtm
Breast NeoplasmsAdm , Atm , Dusp1 , Map2k3 , Map3k1
Bronchopulmonary DysplasiaTxn1
cannabis abuseCalm1 , Calm2 , Camk2b
carcinomaCdc42
Cardiac ArrhythmiasAdm
CardiomegalyMap2k6 , Rac1
cardiomyopathyMap3k5 , Mapk11 , Mapk14 , Txn1
CardiotoxicityRac1
Carotid Artery InjuriesDusp1 , Map3k5
cataractAtm
catecholaminergic polymorphic ventricular tachycardiaCalm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
cavernous hemangiomaCcm2
Cell Transformation, NeoplasticRac1
Central Nervous System Vascular MalformationsCcm2
Centronuclear Myopathy 6, with fiber-type disproportionMap3k20
cerebellar ataxiaAtm
cerebral cavernous malformationCcm2
cerebral cavernous malformation 2Ccm2
cerebral infarctionMap3k5
Chemical and Drug Induced Liver InjuryGadd45a , Map3k5
ChloracneGadd45a
cholestasisMapk13 , Mapk14
Chronic Cerebral HypoperfusionMap3k5 , Mapk14
Chronic Lymphocytic Leukemia, B-CellAtm
chronic myeloid leukemiaMapk14
Cocaine-Related DisordersCalm1 , Calm2 , Camk2b , Rps6ka5
Cognition DisordersMap3k5 , Mapk14
colitisDusp1
colon adenocarcinomaRac1
colon adenomaRac1
Colonic NeoplasmsMap2k3 , Map2k6
colorectal cancerRac1
Congenital Heart Defects, Multiple Types, 2Tab2
congestive heart failureAdm , Map3k5 , Rac1
contact dermatitisDusp1 , Txn1
coronary artery diseaseTraf6
Cutaneous Malignant Melanoma, Susceptibility To, 1Rac1
cutaneous T cell lymphomaAtm
cystic fibrosisIrf1
diabetes mellitusMap3k5 , Rac1
diabetic encephalopathyDusp1
Diabetic NephropathiesMapk14
diabetic neuropathyMapk14
diabetic retinopathyAdm
dilated cardiomyopathyAtm , Rac1 , Txn1
disease of cellular proliferationAtm
Drug-Related Side Effects and Adverse ReactionsTxn1
EdemaMap2k6
Endometrial NeoplasmsAtm , Irf1 , Map3k4
endometriosisDusp1
EndotoxemiaMapk14
Esophageal NeoplasmsMap3k3
Experimental ArthritisCdc42 , Map3k5
Experimental Autoimmune EncephalomyelitisDusp10
Experimental Diabetes MellitusAdm , Dusp1 , Map2k3 , Map2k6 , Map3k5 , Txn1
Experimental Liver CirrhosisAdm , Dusp16 , Map3k8
extrahepatic cholestasisMap3k7
fatty liver diseaseTxn1
Fetal Growth RetardationDlk1 , Dusp1
fibrosarcomaCdc42
FibrosisAtm
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
gastric ulcerAdm
gastrointestinal stromal tumorCdon
genetic diseaseAtm , Calm2 , Camk2b , Cdc42 , Cdon , Map3k1 , Ppm1d
glaucomaTxn1
glioblastoma multiformeMap2k3
glomerulonephritisAdm
glucose intoleranceDusp1
head and neck squamous cell carcinomaRac1
Hearing Loss, Cisplatin-InducedCamk2b
Hearing Loss, Noise-InducedTaok1
heart diseaseMapk14
hepatocellular carcinomaAtm , Rac1
hereditary breast ovarian cancer syndromeAtm
Hereditary Neoplastic SyndromesAtm , Irf1 , Ppm1d
holoprosencephalyCdon
holoprosencephaly 1Cdon
holoprosencephaly 11Cdon
human immunodeficiency virus infectious diseaseCdc42 , Gadd45a
Huntington's diseaseDusp1 , Map3k5
HyperalgesiaAdm , Dusp1 , Map2k3
HypercholesterolemiaAtm
hyperinsulinismAdm
hypertensionAdm , Dusp1
hypertrophic cardiomyopathyAdm
Hypertrophy, Left VentricularDusp1 , Rac1
hypohidrotic ectodermal dysplasiaTraf6
Hypoxia-Ischemia, BrainMap3k5
infertilityAtm
InflammationDusp10
Insulin ResistanceAtm
insulinomaAdm
INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLDPpm1d
intellectual disabilityCamk2b
intermediate coronary syndromeTxn1
Intestinal IschemiaAdm
juvenile rheumatoid arthritisDusp1 , Gadd45a
Kidney Reperfusion InjuryAdm , Atm , Map3k5
leishmaniasisDusp1
leukemiaAtm
Leukemia, Prolymphocytic, T-CellAtm
liver diseaseRac1 , Txn1
liver neoplasmMap2k3 , Mapk14
Liver Reperfusion InjuryAdm
Loeys-Dietz Syndrome 4Dusp10
long QT syndrome 1Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
lung cancerIrf1 , Map3k8
lung diseaseIrf1
Lung NeoplasmsIrf1 , Map2k3 , Map3k8 , Mapk14
lymphomaAtm
major depressive disorderCalm2 , Dusp1
malariaMapkapk3
malignant gliomaDlk1 , Ppm1d
malignant hypertensionAdm
malignant mesotheliomaTxn1
Mammary Neoplasms, AnimalCdc42 , Map2k6
Mammary Neoplasms, ExperimentalCdc42 , Dusp1 , Map2k3
mantle cell lymphomaAtm
melanomaAtm , Map3k5 , Rac1
membranous glomerulonephritisMap3k5
Metabolic SyndromeAtm
Microphthalmia, Syndromic 1Map3k1
microvillus inclusion diseaseCdc42
migraineTab2
Multiple AbnormalitiesAtm , Cdc42
Mycobacterium Tuberculosis, Susceptibility To Infection ByMapkapk3
myelodysplastic syndromeDlk1
myocardial infarctionAtm , Map2k6 , Map3k5 , Txn1
Myocardial IschemiaAdm , Dusp1 , Irf1 , Map2k3 , Map3k8 , Mapk14
Myocardial Reperfusion InjuryMap2k6 , Mapk14 , Txn1
myocarditisTxn1
NecrosisCdc42
NeointimaMap3k5
Neoplasm InvasivenessTxn1
Neoplasm MetastasisRac1
nephroblastomaMap3k4
Neurodevelopmental DisordersPpm1d
non-small cell lung carcinomaIrf1
Noonan Like SyndromeCdc42
obesityAdm , Dusp1
obstructive jaundiceAdm
Oculomotor Apraxia, Cogan TypeAtm
osteoporosisAtm , Mapk14
otitis mediaDusp1
Ovarian NeoplasmsDusp1 , Gadd45a , Map2k6
PainAdm
pancreatic cancerAdm , Atm , Cdc42 , Gadd45a
pancreatitisDusp1 , Dusp10
Parkinson's diseaseAtm , Map3k5
patterned macular dystrophyMapkapk3
patterned macular dystrophy 3Mapkapk3
perinatal necrotizing enterocolitisMap3k5
peripheral T-cell lymphomaAtm
peripheral vascular diseaseAdm
phencyclidine abuseCalm1 , Calm2 , Camk2b
Pick's diseaseMap2k6
pleomorphic xanthoastrocytomaCamk2b , Ccm2
polycystic ovary syndromeTab1
portal hypertensionAdm , Dusp1
pre-malignant neoplasmAtm , Ppm1d
Prenatal Exposure Delayed EffectsAtm
progressive supranuclear palsyMap2k6
prostate cancerTaok3
prostate carcinoma in situAtm , Map2k6
Prostatic NeoplasmsAtm , Dusp1 , Gadd45a , Map2k6 , Map3k1 , Map3k7
psoriasisDusp1
pulmonary hypertensionAdm
pulmonary tuberculosisIrf1
renal cell carcinomaAtm
renovascular hypertensionAdm
Reperfusion InjuryAdm , Cdc42 , Irf1 , Txn1
respiratory syncytial virus infectious diseaseIrf1
Respiratory Tract InfectionsIrf1
restrictive cardiomyopathyMap2k3 , Map2k6 , Mapk14
Retina Reperfusion InjuryDusp1
retinal diseaseMap2k3
rheumatoid arthritisTraf6
rhinitisCdc42
Romano-Ward SyndromeCalm2 , Calm3
schizophreniaCamk2b , Taok2
SepsisAdm
septooptic dysplasiaCdon
Shock, HemorrhagicAdm
skin diseaseGadd45b
Smith-Magenis syndromeMap2k3 , Map2k6 , Map3k3 , Ppm1d , Spag9 , Taok1
Spinal Cord InjuriesAtm , Cdc42 , Dusp1 , Irf1 , Map3k5
split hand-foot malformationMap3k20
SPLIT-FOOT MALFORMATION WITH MESOAXIAL POLYDACTYLYMap3k20
Spondylocostal Dysostosis 5Taok2
squamous cell carcinomaAtm , Dusp1
StarvationAdm
status epilepticusAtm
stomach cancerIrf1
Stomach NeoplasmsAtm , Gadd45a , Irf1
StrokeAdm , Irf1
substance-induced psychosisCamk2b
substance-related disorderMknk1
systemic lupus erythematosusGadd45a
Takenouchi-Kosaki SyndromeCdc42
temporal lobe epilepsyCdc42
Thyroid NeoplasmsMap2k3
toxic shock syndromeAdm
transient cerebral ischemiaDusp1 , Dusp16 , Map3k5
Tumor Predisposition SyndromeAtm
type 1 diabetes mellitusDusp1
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusAdm , Calm1
Uniparental Disomy, Paternal, Chromosome 14Dlk1
ureteral obstructionAdm , Irf1
urinary bladder cancerAtm , Dusp1
Usher syndromeDusp10
Uterine Cervical NeoplasmsMap2k3 , Map2k6
Uterine NeoplasmsRac1
vasculitisCcm2
Ventilator-Induced Lung InjuryGadd45a , Map3k5
Ventricular Dysfunction, LeftAtm , Rac1
Ventricular RemodelingMap3k5
visual epilepsyDusp1 , Map3k5
Weight GainCalm1
Wolff-Parkinson-White syndromeMap3k7
Pathway Annotations Associated with Genes in the p38 MAPK signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCalm1
adenine phoshoribosyltransferase deficiency pathwayTxn1
adenosine monophosphate deaminase deficiency pathwayTxn1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3
adenosine signaling pathwayCdc42 , Map2k6 , Map3k1 , Map3k4 , Mapk11
adenylosuccinate lyase deficiency pathwayTxn1
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCalm1
AICA-ribosuria pathwayTxn1
Alzheimer's disease pathwayCalm1 , Calm2 , Calm3
amiodarone pharmacodynamics pathwayCalm1
amlodipine pharmacodynamics pathwayCalm1
amyotrophic lateral sclerosis pathwayMap2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1
angiotensin II signaling pathway via AT2 receptorDusp1
apoptotic cell death pathwayAtm , Traf2
Arf family mediated signaling pathwayRac1
ataxia telangiectasia-mutated (ATM) signaling pathwayAtm , Ppm1d
atenolol pharmacodynamics pathwayCalm1
azathioprine pharmacodynamics pathwayRac1 , Txn1
B cell receptor signaling pathwayRac1
betaxolol pharmacodynamics pathwayCalm1
bisoprolol pharmacodynamics pathwayCalm1
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
bupranolol drug pathwayCalm1
bupranolol pharmacodynamics pathwayCalm1
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Map3k1 , Map3k10 , Map3k11 , Map3k3 , Map3k4 , Map3k7 , Mapk8ip2 , Rac1 , Traf2
calcium/calcium-mediated signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b
calcium/calmodulin dependent kinase 2 signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b
carvedilol pharmacodynamics pathwayCalm1
cell cycle pathway, mitoticAtm , Gadd45a , Gadd45b , Gadd45g
ceramide signaling pathwayCdc42 , Map3k1 , Rac1 , Traf2
Chagas disease pathwayMapk11 , Mapk12 , Mapk13 , Mapk14 , Traf6
chemokine mediated signaling pathwayCdc42 , Rac1
colorectal cancer pathwayRac1
cyclooxygenase mediated pathway of arachidonic acid metabolismMknk1
diltiazem pharmacodynamics pathwayCalm1
disopyramide pharmacodynamics pathwayCalm1
dobutamine pharmacodynamics pathwayCalm1
E-cadherin signaling pathwayCdc42 , Rac1
eicosanoid signaling pathwayMapk11 , Mapk14 , Rac1
endocytosis pathwayCdc42 , Traf6
Endoplasmic Reticulum-associated degradation pathwayTraf2
endothelin signaling pathwayCdc42 , Mapk14 , Rac1
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map3k7 , Rac1
epidermal growth factor/neuregulin signaling pathwayCamk2b
Erk5 MAPK signaling pathwayMap3k3
erythropoietin signaling pathwayMapk14
esmolol pharmacodynamics pathwayCalm1
FasL mediated signaling pathwayMap2k6 , Map3k1 , Mapk11 , Mapk14
Fc epsilon receptor mediated signaling pathwayMap2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1
Fc gamma receptor mediated signaling pathwayCdc42 , Rac1
flecainde pharmacodynamics pathwayCalm1
forkhead class A signaling pathwayDlk1
fosphenytoin pharmacodynamics pathwayCalm1
glioma pathwayCalm1 , Calm2 , Calm3 , Camk2b
glycogen degradation pathwayCalm1 , Calm2 , Calm3
gonadotropin-releasing hormone signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b , Cdc42 , Map2k3 , Map2k6 , Map3k1 , Map3k3 , Map3k4 , Mapk11 , Mapk12 , Mapk13 , Mapk14
Hedgehog signaling pathwayCdon
hepatitis C pathwayIrf1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf2 , Traf6
homologous recombination pathway of double-strand break repairAtm
hypoxia inducible factor pathwayAdm
ibutilide pharmacodynamics pathwayCalm1
influenza A pathwayMap2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCalm1 , Calm2 , Calm3 , Rac1
insulin secretion pathwayCdc42
insulin signaling pathwayCalm1 , Calm2 , Calm3 , Mknk1 , Mknk2
interleukin-1 signaling pathwayMap2k6 , Map3k3 , Map3k7 , Tab1 , Tab2 , Traf6
interleukin-12 signaling pathwayGadd45b , Gadd45g , Map2k3 , Map2k6 , Mapk14
interleukin-2 signaling pathwayMapk11 , Mapk14 , Mapkapk2
interleukin-4 signaling pathwayMapk14
interleukin-6 signaling pathwayIrf1 , Map2k6 , Mapk11 , Mapk14 , Rac1
isoprenaline pharmacodynamics pathwayCalm1
isradipine pharmacodynamics pathwayCalm1
Jak-Stat signaling pathwayIrf1
Kelley-Seegmiller syndrome pathwayTxn1
Leishmaniasis pathwayMap3k7 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf6
Lesch-Nyhan syndrome pathwayTxn1
levobunolol pharmacodynamics pathwayCalm1
lidocaine pharmacodynamics pathwayCalm1
long term potentiationCalm1 , Calm2 , Calm3 , Camk2b
measles pathwayMap3k7 , Traf6
mercaptopurine pharmacodynamics pathwayRac1 , Txn1
mercaptopurine pharmacokinetics pathwayRac1
metoprolol pharmacodynamics pathwayCalm1
mexiletine pharmacodynamics pathwayCalm1
mitogen activated protein kinase signaling pathwayCdc42 , Dusp1 , Dusp10 , Dusp16 , Dusp9 , Gadd45a , Gadd45b , Gadd45g , Map2k3 , Map2k6 , Map3k1 , Map3k11 , Map3k20 , Map3k3 , Map3k4 , Map3k6 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk8ip2 , Mapkapk2 , Mapkapk3 , Mapkapk5 , Mknk1 , Mknk2 , Rac1 , Rps6ka5 , Taok1 , Taok2 , Taok3 , Traf2 , Traf6
molybdenum cofactor deficiency pathwayTxn1
mTOR signaling pathwayRac1
myocarditis pathwayRac1
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Cdc42 , Rac1
nadolol pharmacodynamics pathwayCalm1
nebivolol pharmacodynamics pathwayCalm1
neurotrophic factor signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b , Cdc42 , Map3k1 , Map3k3 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapkapk2 , Rac1 , Rps6ka5 , Traf6
nifedipine pharmacodynamics pathwayCalm1
nimodipine pharmacodynamics pathwayCalm1
nisoldipine pharmacodynamics pathwayCalm1
nitrendipine pharmacodynamics pathwayCalm1
NOD-like receptor signaling pathwayMap3k7 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf6
Notch signaling pathwayDlk1
nuclear factor kappa B signaling pathwayAtm , Irf1 , Map3k7 , Mapk14 , Tab1 , Tab2 , Traf6
p38 MAPK signaling pathwayAdm , Atm , Bnip2 , Calm1 , Calm2 , Calm3 , Camk2b , Ccm2 , Cdc42 , Cdon , Dlk1 , Dusp1 , Dusp10 , Dusp16 , Dusp9 , Gadd45a , Gadd45b , Gadd45g , Irf1 , Map2k3 , Map2k6 , Map3k1 , Map3k10 , Map3k11 , Map3k20 , Map3k3 , Map3k4 , Map3k5 , Map3k6 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk8ip2 , Mapkapk2 , Mapkapk3 , Mapkapk5 , Mknk1 , Mknk2 , Ppm1d , Rac1 , Rps6ka4 , Rps6ka5 , Spag9 , Tab1 , Tab2 , Taok1 , Taok2 , Taok3 , Traf2 , Traf6 , Txn1
p53 signaling pathwayAtm , Gadd45a , Gadd45b , Gadd45g , Mapk14 , Ppm1d
pancreatic cancer pathwayCdc42 , Rac1
penbutolol pharmacodynamics pathwayCalm1
phagocytosis pathwayRac1
phenytoin pharmacodynamics pathwayCalm1
phosphatidylinositol 3-kinase class I signaling pathwayRac1
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3
phosphatidylinositol 3-kinase-Akt signaling pathwayMap3k5
pindolol pharmacodynamics pathwayCalm1
platelet-derived growth factor signaling pathwayRac1
procainamide pharmacodynamics pathwayCalm1
propranolol pharmacodynamics pathwayCalm1
purine metabolic pathwayTxn1
purine nucleoside phosphorylase deficiency pathwayTxn1
quinidine pharmacodynamics pathwayCalm1
Reelin signaling pathwayMap3k11
renal cell carcinoma pathwayCdc42 , Rac1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k1 , Map3k7 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf2 , Traf6
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Rac1
small cell lung carcinoma pathwayTraf2 , Traf6
sotalol pharmacodynamics pathwayCalm1
sphingosine 1-phosphate signaling pathwayCdc42 , Mapk14 , Rac1
syndecan signaling pathwayRac1
T cell receptor signaling pathwayCdc42 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap3k1 , Mknk1 , Mknk2 , Rps6ka4 , Rps6ka5
timolol pharmacodynamics pathwayCalm1
tioguanine pharmacodynamics pathwayRac1 , Txn1
Toll-like receptor signaling pathwayMap2k3 , Map2k6 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1 , Tab1 , Tab2 , Traf6
toxoplasmosis pathwayMap2k3 , Map2k6 , Map3k7 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf6
Trail mediated signaling pathwayMap3k1 , Traf2
transforming growth factor-beta Smad dependent signaling pathwayMap3k7 , Tab1 , Tab2
tuberculosis pathwayCalm1 , Calm2 , Calm3 , Camk2b , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Traf6
tumor necrosis factor mediated signaling pathwayMap2k3 , Map3k1 , Map3k3 , Map3k5 , Map3k7 , Tab1 , Tab2 , Traf2 , Txn1
type II interferon signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b , Irf1 , Map3k1 , Map3k11
ubiquitin/proteasome degradation pathwayMap3k1 , Traf6
vascular endothelial growth factor signaling pathwayCalm1 , Calm2 , Calm3 , Cdc42 , Map2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapkapk2 , Mapkapk3 , Rac1
verapamil pharmacodynamics pathwayCalm1
visual phototransduction pathwayCalm1 , Calm2 , Calm3
Wnt signaling pathwayCamk2b , Map3k7 , Rac1
Wnt signaling, non-canonical pathwayCdc42 , Map3k7 , Rac1 , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRac1
xanthinuria type I pathwayTxn1
xanthinuria pathwayTxn1
xanthinuria type II pathwayTxn1
Phenotype Annotations Associated with Genes in the p38 MAPK signaling pathway

References Associated with the p38 MAPK signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: